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147 results on '"De Los Angeles, Alejandro"'

1. Why it is important to study human–monkey embryonic chimeras in a dish

Author

De Los Angeles, Alejandro, Regenberg, Alan, Mascetti, Victoria, Benvenisty, Nissim, Church, George, Deng, Hongkui, Izpisua Belmonte, Juan Carlos, Ji, Weizhi, Koplin, Julian, Loh, Yuin-Han, Niu, Yuyu, Pei, Duanqing, Pera, Martin, Pho, Nam, Pinzon-Arteaga, Carlos, Saitou, Mitinori, Silva, Jose C. R., Tao, Tan, Trounson, Alan, Warrier, Tushar, and Zambidis, Elias T.

Published
2022
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10. Replication Stress Impairs Chromosome Segregation and Preimplantation Development in Human Embryos

Author

Palmerola, Katherine L., primary, Amrane, Selma, additional, De Los Angeles, Alejandro, additional, Xu, Shuangyi, additional, Wang, Ning, additional, de Pinho, Joao, additional, Zuccaro, Michael V., additional, Taglialatela, Angelo, additional, Massey, Dashiell J., additional, Turocy, Jenna, additional, Robles, Alex, additional, Subbiah, Anisa, additional, Prosser, Bob, additional, Lobo, Rogerio, additional, Ciccia, Alberto, additional, Koren, Amnon, additional, Baslan, Timour, additional, and Egli, Dieter, additional

Published
2022
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12. Failure to replicate the STAP cell phenomenon

Author

De Los Angeles, Alejandro, Ferrari, Francesco, Fujiwara, Yuko, Mathieu, Ronald, Lee, Soohyun, Lee, Semin, Tu, Ho-Chou, Ross, Samantha, Chou, Stephanie, Nguyen, Minh, Wu, Zhaoting, Theunissen, Thorold W., Powell, Benjamin E., Imsoonthornruksa, Sumeth, Chen, Jiekai, Borkent, Marti, Krupalnik, Vladislav, Lujan, Ernesto, Wernig, Marius, Hanna, Jacob H., Hochedlinger, Konrad, Pei, Duanqing, Jaenisch, Rudolf, Deng, Hongkui, Orkin, Stuart H., Park, Peter J., and Daley, George Q.

Subjects
Cytological research, Stem cells -- Physiological aspects, Medical protocols -- Research, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): Alejandro De Los Angeles [1, 2, 3]; Francesco Ferrari [4]; Yuko Fujiwara [1, 2, 3]; Ronald Mathieu [5]; Soohyun Lee [4]; Semin Lee [4]; Ho-Chou Tu [1, 2, 3]; [...]

Published
2015
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13. Hallmarks of pluripotency

Author

De Los Angeles, Alejandro, Ferrari, Francesco, Xi, Ruibin, Fujiwara, Yuko, Benvenisty, Nissim, Deng, Hongkui, Hochedlinger, Konrad, Jaenisch, Rudolf, Lee, Soohyun, Leitch, Harry G., Lensch, M. William, Lujan, Ernesto, Pei, Duanqing, Rossant, Janet, Wernig, Marius, Park, Peter J., and Daley, George Q.

Published
2015
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18. Long read sequencing reveals novel isoforms and insights into splicing regulation during cell state changes

Author

Wright, David J, primary, Hall, Nicola, additional, Irish, Naomi, additional, Man, Angela L, additional, Glynn, Will, additional, Mould, Arne, additional, De Los Angeles, Alejandro, additional, Angiolini, Emily, additional, Swarbreck, David, additional, Gharbi, Karim, additional, Tunbridge, Elizabeth M, additional, and Haerty, Wilfried, additional

Published
2021
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20. DNA Breaks Due to Replication Stress Limit the Developmental Potential of Human Preimplantation Embryos

Author

Palmerola, Katherine L., primary, Amrane, Selma, additional, De Los Angeles, Alejandro, additional, Xu, Shuangyi, additional, Zuccaro, Michael V., additional, Massey, Dashiell, additional, De Pinho, Joao, additional, Subbiah, Anisa, additional, Prosser, Bob, additional, Lobo, Rogerio, additional, Koren, Amnon, additional, Baslan, Timour, additional, and Egli, Dieter, additional

Published
2021
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34. PRC2 Is Required to Maintain Expression of the Maternal Gtl2-Rian-Mirg Locus by Preventing De Novo DNA Methylation in Mouse Embryonic Stem Cells

Author

Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science, Hendrix, David A., Kellis, Manolis, Das, Partha Pratim, Apostolou, Effie, Buchner, Alice H., Canver, Matthew C., Beyaz, Semir, Ljuboja, Damir, Kuintzle, Rachael, Kim, Woojin, Karnik, Rahul, Shao, Zhen, Xie, Huafeng, Xu, Jian, De Los Angeles, Alejandro, Zhang, Yingying, Choe, Junho, Jun, Don Leong Jia, Shen, Xiaohua, Gregory, Richard I., Daley, George Q., Meissner, Alexander, Hochedlinger, Konrad, Kim, Jonghwan, Orkin, Stuart H., Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science, Hendrix, David A., Kellis, Manolis, Das, Partha Pratim, Apostolou, Effie, Buchner, Alice H., Canver, Matthew C., Beyaz, Semir, Ljuboja, Damir, Kuintzle, Rachael, Kim, Woojin, Karnik, Rahul, Shao, Zhen, Xie, Huafeng, Xu, Jian, De Los Angeles, Alejandro, Zhang, Yingying, Choe, Junho, Jun, Don Leong Jia, Shen, Xiaohua, Gregory, Richard I., Daley, George Q., Meissner, Alexander, Hochedlinger, Konrad, Kim, Jonghwan, and Orkin, Stuart H.

Abstract

DNMT3L, a member of DNA methyltransferases family, is present only in mammals. As it provides specificity to the action of de novo methyltransferases, DNMT3A and DNMT3B and interacts with histone H3, DNMT3L has been invoked as the molecule that can read the histone code and translate it into DNA methylation. It plays an important role in the initiation of genomic imprints during gametogenesis and in nuclear reprogramming. With important functions attributed to it, it is imperative that the DNMT3L expression is tightly controlled. Previously, we had identified a CpG island within the human DNMT3L promoter and first exon that showed loss of DNA methylation in cancer samples. Here we show that this Differentially Methylated CpG island within DNMT3L (DNMT3L DMC) acts to repress transcription, is a Polycomb/Trithorax Response Element (PRE) and interacts with both PRC1 and PRC2 Polycomb repressive complexes. In addition, it adopts inactive chromatin conformation and is associated with other inactive chromatin-specific proteins like SUV39H1 and HP1. The presence of DNMT3L DMC also influences the adjacent promoter to adopt repressive histone post-translational modifications. Due to its association with multiple layers of repressive epigenetic modifications, we believe that PRE within the DNMT3L DMC is responsible for the tight regulation of DNMT3L expression and the aberrant epigenetic modifications of this region leading to DNMT3L overexpression could be the reason of nuclear programming during carcinogenesis., National Institutes of Health (U.S.) (Grant HLBI U01HL100001)

Published
2016

35. Erratum: Corrigendum: Failure to replicate the STAP cell phenomenon

Author

De Los Angeles, Alejandro, primary, Ferrari, Francesco, additional, Fujiwara, Yuko, additional, Mathieu, Ronald, additional, Lee, Soohyun, additional, Lee, Semin, additional, Tu, Ho-Chou, additional, Ross, Samantha, additional, Chou, Stephanie, additional, Nguyen, Minh, additional, Wu, Zhaoting, additional, Theunissen, Thorold W., additional, Powell, Benjamin E., additional, Imsoonthornruksa, Sumeth, additional, Chen, Jiekai, additional, Borkent, Marti, additional, Krupalnik, Vladislav, additional, Lujan, Ernesto, additional, Wernig, Marius, additional, Hanna, Jacob H., additional, Hochedlinger, Konrad, additional, Pei, Duanqing, additional, Jaenisch, Rudolf, additional, Deng, Hongkui, additional, Orkin, Stuart H., additional, Park, Peter J., additional, and Daley, George Q., additional

Published
2015
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36. Erratum: Corrigendum: Hallmarks of pluripotency

Author

De Los Angeles, Alejandro, primary, Ferrari, Francesco, additional, Xi, Ruibin, additional, Fujiwara, Yuko, additional, Benvenisty, Nissim, additional, Deng, Hongkui, additional, Hochedlinger, Konrad, additional, Jaenisch, Rudolf, additional, Lee, Soohyun, additional, Leitch, Harry G., additional, Lensch, M. William, additional, Lujan, Ernesto, additional, Pei, Duanqing, additional, Rossant, Janet, additional, Wernig, Marius, additional, Park, Peter J., additional, and Daley, George Q., additional

Published
2015
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38. PRC2 Is Required to Maintain Expression of the Maternal Gtl2-Rian-Mirg Locus by Preventing De Novo DNA Methylation in Mouse Embryonic Stem Cells

Author

Das, Partha Pratim, primary, Hendrix, David A., additional, Apostolou, Effie, additional, Buchner, Alice H., additional, Canver, Matthew C., additional, Beyaz, Semir, additional, Ljuboja, Damir, additional, Kuintzle, Rachael, additional, Kim, Woojin, additional, Karnik, Rahul, additional, Shao, Zhen, additional, Xie, Huafeng, additional, Xu, Jian, additional, De Los Angeles, Alejandro, additional, Zhang, Yingying, additional, Choe, Junho, additional, Jun, Don Leong Jia, additional, Shen, Xiaohua, additional, Gregory, Richard I., additional, Daley, George Q., additional, Meissner, Alexander, additional, Kellis, Manolis, additional, Hochedlinger, Konrad, additional, Kim, Jonghwan, additional, and Orkin, Stuart H., additional

Published
2015
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39. NF-κB activation impairs somatic cell reprogramming in ageing

Author

Soria-Valles, Clara, primary, Osorio, Fernando G., additional, Gutiérrez-Fernández, Ana, additional, De Los Angeles, Alejandro, additional, Bueno, Clara, additional, Menéndez, Pablo, additional, Martín-Subero, José I., additional, Daley, George Q., additional, Freije, José M. P., additional, and López-Otín, Carlos, additional

Published
2015
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41. Signaling axis involving Hedgehog, Notch, and Scl promotes the embryonic endothelial-to-hematopoietic transition

Author

Kim, Peter Geon, primary, Albacker, Colleen E., additional, Lu, Yi-fen, additional, Jang, Il-ho, additional, Lim, Yoowon, additional, Heffner, Garrett C., additional, Arora, Natasha, additional, Bowman, Teresa V., additional, Lin, Michelle I., additional, Lensch, M. William, additional, De Los Angeles, Alejandro, additional, Zon, Leonard I., additional, Loewer, Sabine, additional, and Daley, George Q., additional

Published
2012
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48. PRC2 Is Required to Maintain Expression of the Maternal Gtl2-Rian-MirgLocus by Preventing De Novo DNA Methylation in Mouse Embryonic Stem Cells

Author

Das, Partha Pratim, Hendrix, David A., Apostolou, Effie, Buchner, Alice H., Canver, Matthew C., Beyaz, Semir, Ljuboja, Damir, Kuintzle, Rachael, Kim, Woojin, Karnik, Rahul, Shao, Zhen, Xie, Huafeng, Xu, Jian, De Los Angeles, Alejandro, Zhang, Yingying, Choe, Junho, Jun, Don Leong Jia, Shen, Xiaohua, Gregory, Richard I., Daley, George Q., Meissner, Alexander, Kellis, Manolis, Hochedlinger, Konrad, Kim, Jonghwan, and Orkin, Stuart H.

Abstract

Polycomb Repressive Complex 2 (PRC2) function and DNA methylation (DNAme) are typically correlated with gene repression. Here, we show that PRC2 is required to maintain expression of maternal microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) from the Gtl2-Rian-Mirglocus, which is essential for full pluripotency of iPSCs. In the absence of PRC2, the entire locus becomes transcriptionally repressed due to gain of DNAme at the intergenic differentially methylated regions (IG-DMRs). Furthermore, we demonstrate that the IG-DMR serves as an enhancer of the maternal Gtl2-Rian-Mirglocus. Further analysis reveals that PRC2 interacts physically with Dnmt3 methyltransferases and reduces recruitment to and subsequent DNAme at the IG-DMR, thereby allowing for proper expression of the maternal Gtl2-Rian-Mirglocus. Our observations are consistent with a mechanism through which PRC2 counteracts the action of Dnmt3 methyltransferases at an imprinted locus required for full pluripotency.

Published
2015
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49. Corrigendum: Failure to replicate the STAP cell phenomenon.

Author

De Los Angeles, Alejandro, Ferrari, Francesco, Fujiwara, Yuko, Mathieu, Ronald, Lee, Soohyun, Lee, Semin, Tu, Ho-Chou, Ross, Samantha, Chou, Stephanie, Nguyen, Minh, Wu, Zhaoting, Theunissen, Thorold W., Powell, Benjamin E., Imsoonthornruksa, Sumeth, Chen, Jiekai, Borkent, Marti, Krupalnik, Vladislav, Lujan, Ernesto, Wernig, Marius, and Hanna, Jacob H.

Published
2016
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50. Corrigendum: Hallmarks of pluripotency.

Author

De Los Angeles, Alejandro, Ferrari, Francesco, Xi, Ruibin, Fujiwara, Yuko, Benvenisty, Nissim, Deng, Hongkui, Hochedlinger, Konrad, Jaenisch, Rudolf, Lee, Soohyun, Leitch, Harry G., Lensch, M. William, Lujan, Ernesto, Pei, Duanqing, Rossant, Janet, Wernig, Marius, Park, Peter J., and Daley, George Q.

Published
2016
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