26 results on '"De Leeuw F.E."'
Search Results
2. Prodromal Transient Ischemic Attack or Minor Stroke and Outcome in Basilar Artery Occlusion
- Author
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Weber, A.M., Donnan, G.A., Thijs, V., Peeters, A., de Freitas, G.R., Conforto, A.B., Miranda-Alves, M., Massaro, A., Ijäs, P., Bogoslovsky, T., Lindsberg, P.J., Weimar, C., Benemann, J., Kraywinkel, K., Haverkamp, C., Michalski, D., Weissenborn, K., Goertler, M., Kloth, A., Bitsch, A., Mieck, T., Machetanz, J., Möller, P., Huber, R., Kaendler, S., Rueckert, C., Audebert, H., Müller, R., Vatankhah, B., Pfefferkorn, T., Mayer, T.E., Szabo, K., Disque, C., Busse, O., Berger, C., Hacke, W., Schwammenthal, Y., Orion, D., Tanne, D., Bergui, M., Pozzati, E., Schonewille, W.J., Algra, A., Kappelle, L.J., Luijckx, G.J., Vroomen, P., Vergouwen, M.D., Roos, Y., Stam, J., Bienfait, P., de Leeuw, F.E., de Kort, P., Dippel, D., Baird, T., Muir, K., Pagola, J., Ribo, M., Molina, C., Gonzales, A., Gil-Peralta, A., Norrving, B., Arnold, M., Fischer, U., Gralla, J., Mattle, H., Schroth, G., Michel, P., Engelter, S.T., Wetzel, S., Lyrer, P., Gandjour, J., Michael, N., Baumgartner, R., Tettenborn, B., Hungerbuehler, H., Wijman, C.A.C., Finley Caulfield, A., Lansberg, M., Schwartz, N., Venkatasubramanian, C., Garami, Z., Bogaard, S., Yatzu, F., Grotta, J., Conforto, Adriana B., de Freitas, Gabriel R., Schonewille, Wouter J., Kappelle, L. Jaap, and Algra, Ale
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- 2015
- Full Text
- View/download PDF
3. Microstructural integrity of the cingulum is related to verbal memory performance in elderly with cerebral small vessel disease: The RUN DMC study
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van der Holst, H.M., Tuladhar, A.M., van Norden, A.G.W., de Laat, K.F., van Uden, I.W.M., van Oudheusden, L.J.B., Zwiers, M.P., Norris, D.G., Kessels, R.P.C., and de Leeuw, F.E.
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- 2013
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4. Dementia: Alzheimer pathology and vascular factors: From mutually exclusive to interaction
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van Norden, Anouk G.W., van Dijk, Ewoud J., de Laat, Karlijn F., Scheltens, Philip, OldeRikkert, Marcel G.M., and de Leeuw, F.E.
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- 2012
- Full Text
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5. Endovascular Thrombectomy in Young Patients With Stroke: A MR CLEAN Registry Study
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Brouwer, J., Smaal, J.A., Emmer, B.J., de Ridder, I.R., van den Wijngaard, I.R., de Leeuw, F.E., Hofmeijer, J., van Zwam, W.H., Martens, J.M., Roos, Y.B.W.E.M., Majoie, C.B., van Oostenbrugge, R.J., Coutinho, J.M., MR CLEAN Registry Investigators, Brouwer, J., Smaal, J.A., Emmer, B.J., de Ridder, I.R., van den Wijngaard, I.R., de Leeuw, F.E., Hofmeijer, J., van Zwam, W.H., Martens, J.M., Roos, Y.B.W.E.M., Majoie, C.B., van Oostenbrugge, R.J., Coutinho, J.M., and MR CLEAN Registry Investigators
- Abstract
Background and Purpose: Acute ischemic stroke due to large vessel occlusion is uncommon in young adults. We assessed stroke cause in young patients and compared their outcomes after endovascular thrombectomy with older patients. Methods: We used data (March 2014 until November 2017) of patients with an anterior circulation large vessel occlusion stroke from the MR CLEAN (Multicenter Randomized Controlled Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands) Registry, a nationwide, prospective study on endovascular thrombectomy in the Netherlands. We compared young patients (18-49 years) with older patients (>= 50 years). Outcomes included modified Rankin Scale score after 90 days (both shift and dichotomized analyses), expanded Thrombolysis in Cerebral Infarction score, and symptomatic intracranial hemorrhage. Analyses were adjusted for confounding. Results: We included 3256 patients, 310 (10%) were 18 to 49 years old. Young patients had lower median National Institutes of Health Stroke Scale scores (14 versus 16, P<0.001) and less cardiovascular comorbidities than older patients. Stroke etiologies in young patients included carotid dissection (16%), cardio-embolism (15%), large artery atherosclerosis (10%), and embolic stroke of undetermined source (31%). Clinical outcome was better in young than older patients (acOR for modified Rankin Scale shift: 1.8 [95% CI, 1.5-2.2]; functional independence [modified Rankin Scale score 0-2] 61 versus 39% [adjusted odds ratio, 2.1 [95% CI, 1.6-2.8]); mortality 7% versus 32%, adjusted odds ratio, 0.2 [95% CI, 0.1-0.3]). Symptomatic intracranial hemorrhage occurred less frequently in young patients (3% versus 6%, adjusted odds ratio, 0.5 [95% CI, 0.2-1.00]). Successful reperfusion (expanded Thrombolysis in Cerebral Infarction Score 2b-3) did not differ between groups. Onset to reperfusion time was shorter in young patients (253 versus 255 minutes, adjusted B in minutes 12.4 [95% CI, 2.4-22.5]). Concl
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- 2022
6. Innate immune activation is associated with progression of cerebral small vessel disease
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Noz, M.P., primary, Telgte, A Ter, additional, Wiegertjes, K., additional, Joosten, L.A.B., additional, Netea, M.G., additional, de Leeuw, F.E., additional, and Riksen, N.P., additional
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- 2018
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7. Predictors of mortality in cerebral small vessel disease patients: The run dmc study
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van der Holst, E., van Uden, I.W.M., Rutten-Jacobs, L.C.A., Tuladhar, Anil M., de Laat, K.F., van Norden, A.G.W., Norris, D.G., van Dijk, E.J., de Leeuw, F.E., Faculty of Science and Technology, and Magnetic Detection and Imaging
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2023 OA procedure ,Biophysics ,150 000 MR Techniques in Brain Function - Abstract
Background: Information about life expectancy is very important in medical decision making. Recent attention has been drawn to gait speed, cognitive function and diverse cerebral imaging parameters as reliable and easily obtainable markers of mortality. However, prediction models combining these different markers are currently lacking and these markers have never been investigated in specific groups of elderly, including older adults with cerebral small vessel disease (SVD). Objective: to investigate the relationship between clinical and imaging parameters and all-cause mortality in elderly with SVD. Methods: 503 independently living elderly participants with SVD on MRI were included (2006). Vital status and cause of death were collected through November, 2014. Cox regression analysis was used to identify baseline clinical and imaging predictors of all-cause mortality, adjusted for age, sex and vascular risk factors. Prediction models of all-cause mortality were constructed to study which parameters were most predictive. Results: 80 participants died. Mean follow-up duration was 7.8 years and cumulative 7.5-year risk of mortality was 13.2%. In the prediction of all-cause mortality, gait speed (HR1.13 per 0.1 m/s slower gait, 95% CI:1.04–1.22), gray matter volume (HR0.75 per standard deviation (SD) increase, 95% CI:0.56–0.99) and structural integrity of the white matter, assessed by diffusion tensor imaging using mean diffusivity (HR1.53 per SD increase, 95% CI:1.19–1.96) had the best predictive ability, next to age, sex and vascular risk factors. Conclusions: Gait speed, gray matter volume and structural integrity of the white matter are the main predictors of mortality at 7.5-years follow-up in elderly with SVD and could possibly be targets for preventive interventions.
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- 2015
8. Associations between structural network connectivity, gait and cognition in small vessel disease
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Tuladhar, A., van der Holst, H.M., Shumskaya, E., van Dijk, E.J., van Uden, I.W.M., de Laat, K.F., van Norden, A.G.W., Norris, D.G., de Leeuw, F.E., Faculty of Science and Technology, and Magnetic Detection and Imaging
- Subjects
2023 OA procedure ,Biophysics ,150 000 MR Techniques in Brain Function - Abstract
Cerebral small vessel disease (SVD), including white matter hyperintensities (WMH) and lacunes of presumed vascular origin, affects gait by disrupting important white matter tracks. However, little is known about the relationship between the structural network connectivity and gait in subjects with cerebral SVD, and the interaction with cognitive function. We assessed gait characteristics (stride length, cadence and stride width, as well as Tinetti and Timed-Up-and-Go test) of 423 subjects with cerebral SVD. The structural network was constructed using diffusion tensor imaging and tractography. We applied graph-theory to calculate network efficiency from the undirected weighted network. Associations between network measures, conventional MRI markers for SVD, gait performances and cognitive index as global cognitive function were tested. Network measures were associated with conventional MRI markers for SVD (WMH and lacunes) and with gait performances. Stride length, Tinetti and Timed-Up-and-Go test were associated with network measures, independent of WMH or lacunes. However, after adjusting for cognitive index, these associations diminished and were not significant anymore. In the mediation analyses, cognitive index mediated the association between global efficiency and stride length, Tinetti and Timed-Up-and-go test. Regional analysis showed widespread involvement of cortical regions in gait performance, including frontal motor, cingulate and visuospatial regions, which diminished after adjusting for cognitive index. These results suggest that measures for network disruption were associated with gait performance, possibly indirectly by disrupting brain network responsible for cognitive function and hereby impairing gait performance.
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- 2015
9. Factors Associated With 8-Year Mortality in Older Patients With Cerebral Small Vessel Disease The Radboud University Nijmegen Diffusion Tensor and Magnetic Resonance Cohort (RUN DMC) Study
- Author
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van der Holst, H.M., van Uden, I.W.M., Tuladhar, A.M., de Laat, K.F., van Norden, A.G.W., Norris, D.G., van Dijk, E.J., Rutten-Jacobs, L.C.A., de Leeuw, F.E., van der Holst, H.M., van Uden, I.W.M., Tuladhar, A.M., de Laat, K.F., van Norden, A.G.W., Norris, D.G., van Dijk, E.J., Rutten-Jacobs, L.C.A., and de Leeuw, F.E.
- Abstract
Contains fulltext : 158761.pdf (publisher's version ) (Closed access)
- Published
- 2016
10. Door-to-needle time bij intraveneuze trombolyse: interpretatie en registratie
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Kruyt, N.D., Beenen, L.F.M., van den Berg Vos, R.M., Dippel, D.W.J., Imanse, G., Kwa, V.I.H., de Leeuw, F.E., Luijckx, G., Nederkoorn, P.J., van Oostenbrugge, R.J., Visser, M.C., van der Worp, H.B., Wermer, M.J., Zinkstok, S.M., Roos, Y.B., Neurology, Other Research, Radiology and Nuclear Medicine, Amsterdam Cardiovascular Sciences, Amsterdam Neuroscience, and NCA - Neurodegeneration
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- 2011
11. Prodromal Transient Ischemic Attack or Minor Stroke and Outcome in Basilar Artery Occlusion
- Author
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Conforto, Adriana B., primary, de Freitas, Gabriel R., additional, Schonewille, Wouter J., additional, Kappelle, L. Jaap, additional, Algra, Ale, additional, Weber, A.M., additional, Donnan, G.A., additional, Thijs, V., additional, Peeters, A., additional, de Freitas, G.R., additional, Conforto, A.B., additional, Miranda-Alves, M., additional, Massaro, A., additional, Ijäs, P., additional, Bogoslovsky, T., additional, Lindsberg, P.J., additional, Weimar, C., additional, Benemann, J., additional, Kraywinkel, K., additional, Haverkamp, C., additional, Michalski, D., additional, Weissenborn, K., additional, Goertler, M., additional, Kloth, A., additional, Bitsch, A., additional, Mieck, T., additional, Machetanz, J., additional, Möller, P., additional, Huber, R., additional, Kaendler, S., additional, Rueckert, C., additional, Audebert, H., additional, Müller, R., additional, Vatankhah, B., additional, Pfefferkorn, T., additional, Mayer, T.E., additional, Szabo, K., additional, Disque, C., additional, Busse, O., additional, Berger, C., additional, Hacke, W., additional, Schwammenthal, Y., additional, Orion, D., additional, Tanne, D., additional, Bergui, M., additional, Pozzati, E., additional, Schonewille, W.J., additional, Algra, A., additional, Kappelle, L.J., additional, Luijckx, G.J., additional, Vroomen, P., additional, Vergouwen, M.D., additional, Roos, Y., additional, Stam, J., additional, Bienfait, P., additional, de Leeuw, F.E., additional, de Kort, P., additional, Dippel, D., additional, Baird, T., additional, Muir, K., additional, Pagola, J., additional, Ribo, M., additional, Molina, C., additional, Gonzales, A., additional, Gil-Peralta, A., additional, Norrving, B., additional, Arnold, M., additional, Fischer, U., additional, Gralla, J., additional, Mattle, H., additional, Schroth, G., additional, Michel, P., additional, Engelter, S.T., additional, Wetzel, S., additional, Lyrer, P., additional, Gandjour, J., additional, Michael, N., additional, Baumgartner, R., additional, Tettenborn, B., additional, Hungerbuehler, H., additional, Wijman, C.A.C., additional, Finley Caulfield, A., additional, Lansberg, M., additional, Schwartz, N., additional, Venkatasubramanian, C., additional, Garami, Z., additional, Bogaard, S., additional, Yatzu, F., additional, and Grotta, J., additional
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- 2015
- Full Text
- View/download PDF
12. Carotid artery stenting compared with endarterectomy in patients with symptomatic carotid stenosis (International Carotid Stenting Study): an interim analysis of a randomised controlled trial.
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Giroux M.-F., Prakash K.G., Serracino-Inglott F., Subramanian G., Symth J.V., Walker M.G., Clarke M., Davis M., Dixit S.A., Dorman P., Dyker A., Ford G., Golkar A., Jackson R., Jayakrishnan V., Lambert D., Lees T., Louw S., Mendelow A.D., Rodgers H., Rose J., Stansby G., Wyatt M., Baker T., Baldwin N., Jones L., Mitchell D., Munro E., Thornton M., Baker D., Davis N., Hamilton G., Platts A., Tibballs J., Beard J., Cleveland T., Dodd D., Gaines P., Lonsdale R., Nair R., Nassef A., Nawaz S., Venables G., Belli A., Clifton A., Cloud G., Halliday A., Markus H., McFarland R., Morgan R., Pereira A., Thompson A., Chataway J., Cheshire N., Gibbs R., Hammady M., Jenkins M., Malik I., Wolfe J., Adiseshiah M., Bishop C., Brew S., Brookes J., Jager R., Kitchen N., Ashleigh R., Butterfield S., Gamble G.E., Nasim A., O'Neill P., Wong J., Edwards R.D., Lees K.R., MacKay A.J., Moss J., Rogers P., Ederle J., Dobson J., Featherstone R.L., Bonati L.H., van der Worp H.B., de Borst G.J., Hauw Lo T., Dorman P.J., Macdonald S., Lyrer P.A., McCollum C., Nederkoorn P.J., Brown M.M., Algra A., Bamford J., Bland M., Hacke W., Mas J.L., McGuire A.J., Sidhu P., Bradbury A., Collins R., Molyneux A., Naylor R., Warlow C., Ferro M., Thomas D., Featherstone R.F., Tindall H., McCabe D., Wallis A., Coward L., Brooks M., Chambers B., Chan A., Chu P., Clark D., Dewey H., Donnan G., Fell G., Hoare M., Molan M., Roberts A., Roberts N., Beiles B., Bladin C., Clifford C., Grigg M., New G., Bell R., Bower S., Chong W., Holt M., Saunder A., Than P.G., Gett S., Leggett D., McGahan T., Quinn J., Ray M., Wong A., Woodruff P., Foreman R., Schultz D., Scroop R., Stanley B., Allard B., Atkinson N., Cambell W., Davies S., Field P., Milne P., Mitchell P., Tress B., Yan B., Beasley A., Dunbabin D., Stary D., Walker S., Cras P., d'Archambeau O., Hendriks J.M.H., Van Schil P., Bosiers M., Deloose K., van Buggenhout E., De Letter J., Devos V., Ghekiere J., Vanhooren G., Astarci P., Hammer F., Lacroix V., Verhelst R., DeJaegher L., Peeters A., Verbist J., Blair J.-F., Caron J.L., Daneault N., Guilbert F., Lanthier S., Lebrun L.-H., Oliva V., Raymond J., Roy D., Soulez G., Weill A., Hill M., Hu W., Hudion M., Morrish W., Sutherland G., Alback A., Harno H., Ijas P., Kaste M., Lepantalo M., Mustanoja S., Paananen T., Porras M., Putaala J., Railo M., Sairanen T., Soinne L., Vehmas A., Vikatmaa P., Goertler M., Halloul Z., Skalej M., Brennan P., Kelly C., Leahy A., Moroney J., Thornton J., Koelemay M.J.W., Reekers J.A.A., Roos Y.B.W.E.M., Hendriks J.M., Koudstaal P.J., Pattynama P.M.T., van der Lugt A., van Dijk L.C., van Sambeek M.R.H.M., van Urk H., Verhagen H.J.M., Bruijninckx C.M.A., de Bruijn S.F., Keunen R., Knippenberg B., Mosch A., Treurniet F., van Dijk L., van Overhagen H., Wever J., de Beer F.C., van den Berg J.S.P., van Hasselt B.A.A.M., Zeilstra D.J., Boiten J., de Mol van Otterloo J.C.A., de Vries A.C., Lycklama a Nijeholt G.J., van der Kallen B.F.W., Blankensteijn J.D., De Leeuw F.E., Schultze Kool L.J., van der Vliet J.A., de Kort G.A.P., Kapelle L.J., Lo T.H., Mali W.P.T.M., Moll F., Verhagen H., Barber P.A., Bourchier R., Hill A., Holden A., Stewart J., Bakke S.J., Krohg-Sorensen K., Skjelland M., Tennoe B., Bialek P., Biejat Z., Czepiel W., Czlonkowska A., Dowzenko A., Jedrzejewska J., Kobayashi A., Lelek M., Polanski J., Kirbis J., Milosevic Z., Zvan B., Blasco J., Chamorro A., Macho J., Obach V., Riambau V., San Roman L., Branera J., Canovas D., Estela J., Gimenez Gaibar A., Perendreu J., Bjorses K., Gottsater A., Ivancev K., Maetzsch T., Sonesson B., Berg B., Delle M., Formgren J., Gillgren P., Kall T.-B., Konrad P., Nyman N., Takolander R., Andersson T., Malmstedt J., Soderman M., Wahlgren C., Wahlgren N., Binaghi S., Hirt L., Michel P., Ruchat P., Engelter S.T., Fluri F., Guerke L., Jacob A.L., Kirsch E., Radue E.-W., Stierli P., Wasner M., Wetzel S., Bonvin C., Kalangos A., Lovblad K., Murith N., Ruefenacht D., Sztajzel R., Higgins N., Kirkpatrick P.J., Martin P., Adam D., Bell J., Bradbury A.W., Crowe P., Gannon M., Henderson M.J., Sandler D., Shinton R.A., Scriven J.M., Wilmink T., D'Souza S., Egun A., Guta R., Punekar S., Seriki D.M., Thomson G., Brennan J.A., Enevoldson T.P., Gilling-Smith G., Gould D.A., Harris P.L., McWilliams R.G., Nasser H.-C., White R., Giroux M.-F., Prakash K.G., Serracino-Inglott F., Subramanian G., Symth J.V., Walker M.G., Clarke M., Davis M., Dixit S.A., Dorman P., Dyker A., Ford G., Golkar A., Jackson R., Jayakrishnan V., Lambert D., Lees T., Louw S., Mendelow A.D., Rodgers H., Rose J., Stansby G., Wyatt M., Baker T., Baldwin N., Jones L., Mitchell D., Munro E., Thornton M., Baker D., Davis N., Hamilton G., Platts A., Tibballs J., Beard J., Cleveland T., Dodd D., Gaines P., Lonsdale R., Nair R., Nassef A., Nawaz S., Venables G., Belli A., Clifton A., Cloud G., Halliday A., Markus H., McFarland R., Morgan R., Pereira A., Thompson A., Chataway J., Cheshire N., Gibbs R., Hammady M., Jenkins M., Malik I., Wolfe J., Adiseshiah M., Bishop C., Brew S., Brookes J., Jager R., Kitchen N., Ashleigh R., Butterfield S., Gamble G.E., Nasim A., O'Neill P., Wong J., Edwards R.D., Lees K.R., MacKay A.J., Moss J., Rogers P., Ederle J., Dobson J., Featherstone R.L., Bonati L.H., van der Worp H.B., de Borst G.J., Hauw Lo T., Dorman P.J., Macdonald S., Lyrer P.A., McCollum C., Nederkoorn P.J., Brown M.M., Algra A., Bamford J., Bland M., Hacke W., Mas J.L., McGuire A.J., Sidhu P., Bradbury A., Collins R., Molyneux A., Naylor R., Warlow C., Ferro M., Thomas D., Featherstone R.F., Tindall H., McCabe D., Wallis A., Coward L., Brooks M., Chambers B., Chan A., Chu P., Clark D., Dewey H., Donnan G., Fell G., Hoare M., Molan M., Roberts A., Roberts N., Beiles B., Bladin C., Clifford C., Grigg M., New G., Bell R., Bower S., Chong W., Holt M., Saunder A., Than P.G., Gett S., Leggett D., McGahan T., Quinn J., Ray M., Wong A., Woodruff P., Foreman R., Schultz D., Scroop R., Stanley B., Allard B., Atkinson N., Cambell W., Davies S., Field P., Milne P., Mitchell P., Tress B., Yan B., Beasley A., Dunbabin D., Stary D., Walker S., Cras P., d'Archambeau O., Hendriks J.M.H., Van Schil P., Bosiers M., Deloose K., van Buggenhout E., De Letter J., Devos V., Ghekiere J., Vanhooren G., Astarci P., Hammer F., Lacroix V., Verhelst R., DeJaegher L., Peeters A., Verbist J., Blair J.-F., Caron J.L., Daneault N., Guilbert F., Lanthier S., Lebrun L.-H., Oliva V., Raymond J., Roy D., Soulez G., Weill A., Hill M., Hu W., Hudion M., Morrish W., Sutherland G., Alback A., Harno H., Ijas P., Kaste M., Lepantalo M., Mustanoja S., Paananen T., Porras M., Putaala J., Railo M., Sairanen T., Soinne L., Vehmas A., Vikatmaa P., Goertler M., Halloul Z., Skalej M., Brennan P., Kelly C., Leahy A., Moroney J., Thornton J., Koelemay M.J.W., Reekers J.A.A., Roos Y.B.W.E.M., Hendriks J.M., Koudstaal P.J., Pattynama P.M.T., van der Lugt A., van Dijk L.C., van Sambeek M.R.H.M., van Urk H., Verhagen H.J.M., Bruijninckx C.M.A., de Bruijn S.F., Keunen R., Knippenberg B., Mosch A., Treurniet F., van Dijk L., van Overhagen H., Wever J., de Beer F.C., van den Berg J.S.P., van Hasselt B.A.A.M., Zeilstra D.J., Boiten J., de Mol van Otterloo J.C.A., de Vries A.C., Lycklama a Nijeholt G.J., van der Kallen B.F.W., Blankensteijn J.D., De Leeuw F.E., Schultze Kool L.J., van der Vliet J.A., de Kort G.A.P., Kapelle L.J., Lo T.H., Mali W.P.T.M., Moll F., Verhagen H., Barber P.A., Bourchier R., Hill A., Holden A., Stewart J., Bakke S.J., Krohg-Sorensen K., Skjelland M., Tennoe B., Bialek P., Biejat Z., Czepiel W., Czlonkowska A., Dowzenko A., Jedrzejewska J., Kobayashi A., Lelek M., Polanski J., Kirbis J., Milosevic Z., Zvan B., Blasco J., Chamorro A., Macho J., Obach V., Riambau V., San Roman L., Branera J., Canovas D., Estela J., Gimenez Gaibar A., Perendreu J., Bjorses K., Gottsater A., Ivancev K., Maetzsch T., Sonesson B., Berg B., Delle M., Formgren J., Gillgren P., Kall T.-B., Konrad P., Nyman N., Takolander R., Andersson T., Malmstedt J., Soderman M., Wahlgren C., Wahlgren N., Binaghi S., Hirt L., Michel P., Ruchat P., Engelter S.T., Fluri F., Guerke L., Jacob A.L., Kirsch E., Radue E.-W., Stierli P., Wasner M., Wetzel S., Bonvin C., Kalangos A., Lovblad K., Murith N., Ruefenacht D., Sztajzel R., Higgins N., Kirkpatrick P.J., Martin P., Adam D., Bell J., Bradbury A.W., Crowe P., Gannon M., Henderson M.J., Sandler D., Shinton R.A., Scriven J.M., Wilmink T., D'Souza S., Egun A., Guta R., Punekar S., Seriki D.M., Thomson G., Brennan J.A., Enevoldson T.P., Gilling-Smith G., Gould D.A., Harris P.L., McWilliams R.G., Nasser H.-C., and White R.
- Abstract
Background: Stents are an alternative treatment to carotid endarterectomy for symptomatic carotid stenosis, but previous trials have not established equivalent safety and efficacy. We compared the safety of carotid artery stenting with that of carotid endarterectomy. Method(s): The International Carotid Stenting Study (ICSS) is a multicentre, international, randomised controlled trial with blinded adjudication of outcomes. Patients with recently symptomatic carotid artery stenosis were randomly assigned in a 1:1 ratio to receive carotid artery stenting or carotid endarterectomy. Randomisation was by telephone call or fax to a central computerised service and was stratified by centre with minimisation for sex, age, contralateral occlusion, and side of the randomised artery. Patients and investigators were not masked to treatment assignment. Patients were followed up by independent clinicians not directly involved in delivering the randomised treatment. The primary outcome measure of the trial is the 3-year rate of fatal or disabling stroke in any territory, which has not been analysed yet. The main outcome measure for the interim safety analysis was the 120-day rate of stroke, death, or procedural myocardial infarction. Analysis was by intention to treat (ITT). This study is registered, number ISRCTN25337470. Finding(s): The trial enrolled 1713 patients (stenting group, n=855; endarterectomy group, n=858). Two patients in the stenting group and one in the endarterectomy group withdrew immediately after randomisation, and were not included in the ITT analysis. Between randomisation and 120 days, there were 34 (Kaplan-Meier estimate 4.0%) events of disabling stroke or death in the stenting group compared with 27 (3.2%) events in the endarterectomy group (hazard ratio [HR] 1.28, 95% CI 0.77-2.11). The incidence of stroke, death, or procedural myocardial infarction was 8.5% in the stenting group compared with 5.2% in the endarterectomy group (72 vs 44 events; HR 1.69, 1.
- Published
- 2010
13. Carotid artery stenting compared with endarterectomy in patients with symptomatic carotid stenosis (International Carotid Stenting Study): an interim analysis of a randomised controlled trial
- Author
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Ederle, Jörg, Dobson, Joanna, Featherstone, Roland L., Bonati, Leo H., van der Worp, H. Bart, de Borst, Gert J., Hauw Lo, T., Gaines, Peter, Dorman, Paul J., Macdonald, Sumaira, Lyrer, Philippe A., Hendriks, Johanna M., McCollum, Charles, Nederkoorn, Paul J., Brown, Martin M., Algra, A., Bamford, J., Bland, M., Hacke, W., Mas, J.L., McGuire, A.J., Sidhu, P., Bradbury, A., Collins, R., Molyneux, A., Naylor, R., Warlow, C., Ferro, M., Thomas, D., Featherstone, R.F., Tindall, H., McCabe, D.J.H., Wallis, A., Coward, L., Brooks, M., Chambers, B., Chan, A., Chu, P., Clark, D., Dewey, H., Donnan, G., Fell, G., Hoare, M., Molan, M., Roberts, A., Roberts, N., Beiles, B., Bladin, C., Clifford, C., Grigg, M., New, G., Bell, R., Bower, S., Chong, W., Holt, M., Saunder, A., Than, P.G., Gett, S., Leggett, D., McGahan, T., Quinn, J., Ray, M., Wong, A., Woodruff, P., Foreman, R., Schultz, D., Scroop, R., Stanley, B., Allard, B., Atkinson, N., Cambell, W., Davies, S., Field, P., Milne, P., Mitchell, P., Tress, B., Yan, B., Beasley, A., Dunbabin, D., Stary, D., Walker, S., Cras, P., d'Archambeau, O., Hendriks, J.M.H., Van Schil, P., Bosiers, M., Deloose, K., van Buggenhout, E., De Letter, J., Devos, V., Ghekiere, J., Vanhooren, G., Astarci, P., Hammer, F., Lacroix, V., Peeters, A., Verhelst, R., DeJaegher, L., Verbist, J., Blair, J.-F., Caron, J.L., Daneault, N., Giroux, M.-F., Guilbert, F., Lanthier, S., Lebrun, L.-H., Oliva, V., Raymond, J., Roy, D., Soulez, G., Weill, A., Hill, M., Hu, W., Hudion, M., Morrish, W., Sutherland, G., Wong, J., Albäck, A., Harno, H., Ijäs, P., Kaste, M., Lepäntalo, M., Mustanoja, S., Paananen, T., Porras, M., Putaala, J., Railo, M., Sairanen, T., Soinne, L., Vehmas, A., Vikatmaa, P., Goertler, M., Halloul, Z., Skalej, M., Brennan, P., Kelly, C., Leahy, A., Moroney, J., Thornton, J., Koelemay, M.J.W., Reekers, J.A.A., Roos, Y.B.W.E.M., Hendriks, J.M., Koudstaal, P.J., Pattynama, P.M.T., van der Lugt, A., van Dijk, L.C., van Sambeek, M.R.H.M., van Urk, H., Verhagen, H.J.M., Bruijninckx, C.M.A., de Bruijn, S.F., Keunen, R., Knippenberg, B., Mosch, A., Treurniet, F., van Dijk, L., van Overhagen, H., Wever, J., de Beer, F.C., van den Berg, J.S.P., van Hasselt, B.A.A.M., Zeilstra, D.J., Boiten, J., de Mol van Otterloo, J.C.A., de Vries, A.C., Lycklama a Nijeholt, G.J., van der Kallen, B.F.W., Blankensteijn, J.D., De Leeuw, F.E., Schultze Kool, L.J., van der Vliet, J.A., de Kort, G.A.P., Kapelle, L.J., Lo, T.H., Mali, W.P.T.M., Moll, F., Verhagen, H., Barber, P.A., Bourchier, R., Hill, A., Holden, A., Stewart, J., Bakke, S.J., Krohg-Sørensen, K., Skjelland, M., Tennøe, B., Bialek, P., Biejat, Z., Czepiel, W., Czlonkowska, A., Dowzenko, A., Jedrzejewska, J., Kobayashi, A., Lelek, M., Polanski, J., Kirbis, J., Milosevic, Z., Zvan, B., Blasco, J., Chamorro, A., Macho, J., Obach, V., Riambau, V., San Roman, L., Branera, J., Canovas, D., Estela, Jordi, Gimenez Gaibar, A., Perendreu, J., Björses, K., Gottsater, A., Ivancev, K., Maetzsch, T., Sonesson, B., Berg, B., Delle, M., Formgren, J., Gillgren, P., Kall, T.-B., Konrad, P., Nyman, N., Takolander, R., Andersson, T., Malmstedt, J., Soderman, M., Wahlgren, C., Wahlgren, N., Binaghi, S., Hirt, L., Michel, P., Ruchat, P., Engelter, S.T., Fluri, F., Guerke, L., Jacob, A.L., Kirsch, E., Radue, E.-W., Stierli, P., Wasner, M., Wetzel, S., Bonvin, C., Kalangos, A., Lovblad, K., Murith, N., Ruefenacht, D., Sztajzel, R., Higgins, N., Kirkpatrick, P.J., Martin, P., Adam, D., Bell, J., Bradbury, A.W., Crowe, P., Gannon, M., Henderson, M.J., Sandler, D., Shinton, R.A., Scriven, J.M., Wilmink, T., D'Souza, S., Egun, A., Guta, R., Punekar, S., Seriki, D.M., Thomson, G., Brennan, J.A., Enevoldson, T.P., Gilling-Smith, G., Gould, D.A., Harris, P.L., McWilliams, R.G., Nasser, H.-C., White, R., Prakash, K.G., Serracino-Inglott, F., Subramanian, G., Symth, J.V., Walker, M.G., Clarke, M., Davis, M., Dixit, S.A., Dorman, P., Dyker, A., Ford, G., Golkar, A., Jackson, R., Jayakrishnan, V., Lambert, D., Lees, T., Louw, S., Mendelow, A.D., Rodgers, H., Rose, J., Stansby, G., Wyatt, M., Baker, T., Baldwin, N., Jones, L., Mitchell, D., Munro, E., Thornton, M., Baker, D., Davis, N., Hamilton, G., McCabe, D., Platts, A., Tibballs, J., Beard, J., Cleveland, T., Dodd, D., Gaines, P., Lonsdale, R., Nair, R., Nassef, A., Nawaz, S., Venables, G., Belli, A., Clifton, A., Cloud, G., Halliday, A., Markus, H., McFarland, R., Morgan, R., Pereira, A., Thompson, A., Chataway, J., Cheshire, N., Gibbs, R., Hammady, M., Jenkins, M., Malik, I., Wolfe, J., Adiseshiah, M., Bishop, C., Brew, S., Brookes, J., Jäger, R., Kitchen, N., Ashleigh, R., Butterfield, S., Gamble, G.E., Nasim, A., O'Neill, P., Edwards, R.D., Lees, K.R., MacKay, A.J., Moss, J., Rogers, P., Ederle, Jörg, Dobson, Joanna, Featherstone, Roland L., Bonati, Leo H., van der Worp, H. Bart, de Borst, Gert J., Hauw Lo, T., Gaines, Peter, Dorman, Paul J., Macdonald, Sumaira, Lyrer, Philippe A., Hendriks, Johanna M., McCollum, Charles, Nederkoorn, Paul J., Brown, Martin M., Algra, A., Bamford, J., Bland, M., Hacke, W., Mas, J.L., McGuire, A.J., Sidhu, P., Bradbury, A., Collins, R., Molyneux, A., Naylor, R., Warlow, C., Ferro, M., Thomas, D., Featherstone, R.F., Tindall, H., McCabe, D.J.H., Wallis, A., Coward, L., Brooks, M., Chambers, B., Chan, A., Chu, P., Clark, D., Dewey, H., Donnan, G., Fell, G., Hoare, M., Molan, M., Roberts, A., Roberts, N., Beiles, B., Bladin, C., Clifford, C., Grigg, M., New, G., Bell, R., Bower, S., Chong, W., Holt, M., Saunder, A., Than, P.G., Gett, S., Leggett, D., McGahan, T., Quinn, J., Ray, M., Wong, A., Woodruff, P., Foreman, R., Schultz, D., Scroop, R., Stanley, B., Allard, B., Atkinson, N., Cambell, W., Davies, S., Field, P., Milne, P., Mitchell, P., Tress, B., Yan, B., Beasley, A., Dunbabin, D., Stary, D., Walker, S., Cras, P., d'Archambeau, O., Hendriks, J.M.H., Van Schil, P., Bosiers, M., Deloose, K., van Buggenhout, E., De Letter, J., Devos, V., Ghekiere, J., Vanhooren, G., Astarci, P., Hammer, F., Lacroix, V., Peeters, A., Verhelst, R., DeJaegher, L., Verbist, J., Blair, J.-F., Caron, J.L., Daneault, N., Giroux, M.-F., Guilbert, F., Lanthier, S., Lebrun, L.-H., Oliva, V., Raymond, J., Roy, D., Soulez, G., Weill, A., Hill, M., Hu, W., Hudion, M., Morrish, W., Sutherland, G., Wong, J., Albäck, A., Harno, H., Ijäs, P., Kaste, M., Lepäntalo, M., Mustanoja, S., Paananen, T., Porras, M., Putaala, J., Railo, M., Sairanen, T., Soinne, L., Vehmas, A., Vikatmaa, P., Goertler, M., Halloul, Z., Skalej, M., Brennan, P., Kelly, C., Leahy, A., Moroney, J., Thornton, J., Koelemay, M.J.W., Reekers, J.A.A., Roos, Y.B.W.E.M., Hendriks, J.M., Koudstaal, P.J., Pattynama, P.M.T., van der Lugt, A., van Dijk, L.C., van Sambeek, M.R.H.M., van Urk, H., Verhagen, H.J.M., Bruijninckx, C.M.A., de Bruijn, S.F., Keunen, R., Knippenberg, B., Mosch, A., Treurniet, F., van Dijk, L., van Overhagen, H., Wever, J., de Beer, F.C., van den Berg, J.S.P., van Hasselt, B.A.A.M., Zeilstra, D.J., Boiten, J., de Mol van Otterloo, J.C.A., de Vries, A.C., Lycklama a Nijeholt, G.J., van der Kallen, B.F.W., Blankensteijn, J.D., De Leeuw, F.E., Schultze Kool, L.J., van der Vliet, J.A., de Kort, G.A.P., Kapelle, L.J., Lo, T.H., Mali, W.P.T.M., Moll, F., Verhagen, H., Barber, P.A., Bourchier, R., Hill, A., Holden, A., Stewart, J., Bakke, S.J., Krohg-Sørensen, K., Skjelland, M., Tennøe, B., Bialek, P., Biejat, Z., Czepiel, W., Czlonkowska, A., Dowzenko, A., Jedrzejewska, J., Kobayashi, A., Lelek, M., Polanski, J., Kirbis, J., Milosevic, Z., Zvan, B., Blasco, J., Chamorro, A., Macho, J., Obach, V., Riambau, V., San Roman, L., Branera, J., Canovas, D., Estela, Jordi, Gimenez Gaibar, A., Perendreu, J., Björses, K., Gottsater, A., Ivancev, K., Maetzsch, T., Sonesson, B., Berg, B., Delle, M., Formgren, J., Gillgren, P., Kall, T.-B., Konrad, P., Nyman, N., Takolander, R., Andersson, T., Malmstedt, J., Soderman, M., Wahlgren, C., Wahlgren, N., Binaghi, S., Hirt, L., Michel, P., Ruchat, P., Engelter, S.T., Fluri, F., Guerke, L., Jacob, A.L., Kirsch, E., Radue, E.-W., Stierli, P., Wasner, M., Wetzel, S., Bonvin, C., Kalangos, A., Lovblad, K., Murith, N., Ruefenacht, D., Sztajzel, R., Higgins, N., Kirkpatrick, P.J., Martin, P., Adam, D., Bell, J., Bradbury, A.W., Crowe, P., Gannon, M., Henderson, M.J., Sandler, D., Shinton, R.A., Scriven, J.M., Wilmink, T., D'Souza, S., Egun, A., Guta, R., Punekar, S., Seriki, D.M., Thomson, G., Brennan, J.A., Enevoldson, T.P., Gilling-Smith, G., Gould, D.A., Harris, P.L., McWilliams, R.G., Nasser, H.-C., White, R., Prakash, K.G., Serracino-Inglott, F., Subramanian, G., Symth, J.V., Walker, M.G., Clarke, M., Davis, M., Dixit, S.A., Dorman, P., Dyker, A., Ford, G., Golkar, A., Jackson, R., Jayakrishnan, V., Lambert, D., Lees, T., Louw, S., Mendelow, A.D., Rodgers, H., Rose, J., Stansby, G., Wyatt, M., Baker, T., Baldwin, N., Jones, L., Mitchell, D., Munro, E., Thornton, M., Baker, D., Davis, N., Hamilton, G., McCabe, D., Platts, A., Tibballs, J., Beard, J., Cleveland, T., Dodd, D., Gaines, P., Lonsdale, R., Nair, R., Nassef, A., Nawaz, S., Venables, G., Belli, A., Clifton, A., Cloud, G., Halliday, A., Markus, H., McFarland, R., Morgan, R., Pereira, A., Thompson, A., Chataway, J., Cheshire, N., Gibbs, R., Hammady, M., Jenkins, M., Malik, I., Wolfe, J., Adiseshiah, M., Bishop, C., Brew, S., Brookes, J., Jäger, R., Kitchen, N., Ashleigh, R., Butterfield, S., Gamble, G.E., Nasim, A., O'Neill, P., Edwards, R.D., Lees, K.R., MacKay, A.J., Moss, J., and Rogers, P.
- Abstract
Background: Stents are an alternative treatment to carotid endarterectomy for symptomatic carotid stenosis, but previous trials have not established equivalent safety and efficacy. We compared the safety of carotid artery stenting with that of carotid endarterectomy. Methods: The International Carotid Stenting Study (ICSS) is a multicentre, international, randomised controlled trial with blinded adjudication of outcomes. Patients with recently symptomatic carotid artery stenosis were randomly assigned in a 1:1 ratio to receive carotid artery stenting or carotid endarterectomy. Randomisation was by telephone call or fax to a central computerised service and was stratified by centre with minimisation for sex, age, contralateral occlusion, and side of the randomised artery. Patients and investigators were not masked to treatment assignment. Patients were followed up by independent clinicians not directly involved in delivering the randomised treatment. The primary outcome measure of the trial is the 3-year rate of fatal or disabling stroke in any territory, which has not been analysed yet. The main outcome measure for the interim safety analysis was the 120-day rate of stroke, death, or procedural myocardial infarction. Analysis was by intention to treat (ITT). This study is registered, number ISRCTN25337470. Findings: The trial enrolled 1713 patients (stenting group, n=855; endarterectomy group, n=858). Two patients in the stenting group and one in the endarterectomy group withdrew immediately after randomisation, and were not included in the ITT analysis. Between randomisation and 120 days, there were 34 (Kaplan-Meier estimate 4·0%) events of disabling stroke or death in the stenting group compared with 27 (3·2%) events in the endarterectomy group (hazard ratio [HR] 1·28, 95% CI 0·77-2·11). The incidence of stroke, death, or procedural myocardial infarction was 8·5% in the stenting group compared with 5·2% in the endarterectomy group (72 vs 44 events; HR 1·69, 1·16-2
- Published
- 2010
14. Hypertension and cerebral diffusion tensor imaging in small vessel disease
- Author
-
Gons, R.A.R., Laat, K.F. de, Norden, A.G.W. van, Oudheusden, L.J.B. van, Uden, I.W.M. van, Norris, D.G., Zwiers, M.P., de Leeuw, F.E., Gons, R.A.R., Laat, K.F. de, Norden, A.G.W. van, Oudheusden, L.J.B. van, Uden, I.W.M. van, Norris, D.G., Zwiers, M.P., and de Leeuw, F.E.
- Abstract
Contains fulltext : 84437.pdf (publisher's version ) (Open Access)
- Published
- 2010
15. Damage in the dorsal striatum alleviates addictive behavior
- Author
-
Muskens, J.B., primary, Schellekens, A.F.A., additional, de Leeuw, F.E., additional, Tendolkar, I., additional, and Hepark, S., additional
- Published
- 2012
- Full Text
- View/download PDF
16. 'Bubbling brain'
- Author
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Bartholomeus, M.G.T. and de Leeuw, F.E.
- Subjects
Air embolism -- Case studies ,CT imaging -- Analysis ,Skull -- Fractures ,Skull -- Case studies ,Health ,Psychology and mental health - Published
- 2008
17. P1.022 Diffusion tensor imaging and cognitive function in elderly with white matter lesions. The RUN DMC study
- Author
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Van Norden, A.G.W., primary, De Laat, K.F., additional, Van Oudheusden, L.J.B., additional, Van Uden, I.V.M., additional, Gons, R.A.R., additional, Olde Rikkert, M.G.M., additional, Zwiers, M.P., additional, Norris, D.G., additional, and De Leeuw, F.E., additional
- Published
- 2008
- Full Text
- View/download PDF
18. P1.023 Depressive symptoms are related to amygdala volume in elderly with white matter lesions. The RUN DMC study
- Author
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Van Uden, I.W.M., primary, Van Norden, A.G., additional, De Laat, K.F., additional, Van Oudheusden, L.J.B., additional, Gons, R., additional, Tendolkar, I., additional, Norris, D.G., additional, Zwiers, M.P., additional, and De Leeuw, F.E., additional
- Published
- 2008
- Full Text
- View/download PDF
19. P1.005 Diffusion tensor imaging and gait in elderly with white matter lesions. The RUN DMC study
- Author
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De Laat, K.F., primary, Van Norden, A.G.W., additional, Gons, R.A.R., additional, Van Oudheusden, L.J.B., additional, Van Ouden, I., additional, Zwiers, M.P., additional, Olde Rikkert, M.G.M., additional, Norris, D.G., additional, Bloem, B.R., additional, and De Leeuw, F.E., additional
- Published
- 2008
- Full Text
- View/download PDF
20. P1.128 Diffusion tensor imaging of the cerebral white matter. The RUN DMC study
- Author
-
Van Oudheusden, L.J.B., primary, Van Norden, A.G.W., additional, De Laat, K.F., additional, Van Uden, I.W.M., additional, Gons, R.A.R., additional, Zwiers, M.P., additional, Norris, D.G., additional, and De Leeuw, F.E., additional
- Published
- 2008
- Full Text
- View/download PDF
21. 1H chemical shift imaging of the human brain at age 60-90 years reveals metabolic differences between women and men
- Author
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Sijens, P.E., primary, Oudkerk, M., additional, de Leeuw, F.E., additional, de Groot, J.C., additional, Achten, E., additional, Heijboer, R., additional, Hofman, A., additional, and Breteler, M.M.B., additional
- Published
- 1999
- Full Text
- View/download PDF
22. Effects of Various Cryoprotective Agents and Membrane-Stabilizing Compounds on Bull Sperm Membrane Integrity after Cooling and Freezing
- Author
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De Leeuw, F.E., primary, De Leeuw, A.M., additional, Den Daas, J.H.G., additional, Colenbrander, B., additional, and Verkleij, A.J., additional
- Published
- 1993
- Full Text
- View/download PDF
23. 1H chemical shift imaging of the human brain at age 60-90 years reveals metabolic differences between women and men.
- Author
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Sijens, P.E., Oudkerk, M., de Leeuw, F.E., de Groot, J.C., Achten, E., Heijboer, R., Hofman, A., and Breteler, M.M.B.
- Published
- 1999
- Full Text
- View/download PDF
24. Effects of low temperature on bovine sperm plasma membrane
- Author
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De Leeuw, F.E., primary, Colenbrander, B., additional, and Verkleii, A.J., additional
- Published
- 1988
- Full Text
- View/download PDF
25. Cold-induced changes in bovine sperm plasma membrane: A freeze-fracture study
- Author
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De Leeuw, F.E., primary, Colenbrander, B., additional, and Verkleij, A.J., additional
- Published
- 1988
- Full Text
- View/download PDF
26. Neurocognitive mechanisms of visual working memory and episodic memory in healthy aging and after stroke
- Author
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Lugtmeijer, S., Haan, E.H.F. de, Kessels, R.P.C., Leeuw, H.F. de, Geerligs, L., de Haan, Edward, de Leeuw, F.E., Brein en Cognitie (Psychologie, FMG), and Radboud University Nijmegen
- Subjects
Neuro- en revalidatiepsychologie ,Neuropsychology and rehabilitation psychology ,Donders Graduate School for Cognitive Neuroscience series - Abstract
Item does not contain fulltext Our surroundings consist of scenes and objects that have a multitude of visual features: shape, color, texture, size, orientation, and location. We are able to remember which object was where and what features belong to it by forming an internal representation of features and their conjunctions. Some representations only last for a brief period, they are kept in working memory, while other representations remain over a longer period of time, known as episodic memory. The aim of this thesis was to investigate how memory subsystems relate at a behavioral and neural level using novel behavioral paradigms, lesion-symptom mapping, and computational modeling, in healthy adults and stroke patients. Lesions studies in this thesis support the notion of a widely distributed frontoparietal network underlying memory, with a suggestion of specialization for memory subsystems (working memory and episodic memory; feature reporting and binding) and multiple visual representations in the brain. Representations in different areas might compensate for impaired encoding in lesioned areas explaining mostly subtle visual memory impairments following stroke. Experimental studies in this thesis showed that, at a group level, controls outperform patients and younger adults perform better than older adults. At the same time, selective deficits in different subsystems of visual memory are prevalent. This indicates that different neural mechanisms may be involved. It also stresses the need for broad memory examination, as selective memory deficits might easily be missed in standard clinical assessment where testing mainly with verbal materials and with a maximum delay of 30 minutes is the standard. University of Amsterdam, 25 september 2020 Promotores : Haan, E.H.F. de, Kessels, R.P.C., Leeuw, H.F. de Co-promotor : Geerligs, L. 215 p.
- Published
- 2020
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