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2. Tools for large-scale data analytics of an international multi-center study in radiation oncology for cervical cancer

Author

Ecker, Stefan, Kirisits, Christian, Schmid, Maximilian, De Leeuw, Astrid, Seppenwoolde, Yvette, Knoth, Johannes, Trnkova, Petra, Heilemann, Gerd, Sturdza, Alina, Kirchheiner, Kathrin, Spampinato, Sofia, Serban, Monica, Jürgenliemk-Schulz, Ina, Chopra, Supriya, Nout, Remi, Tanderup, Kari, Pötter, Richard, and Eder-Nesvacil, Nicole

Published
2023
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4. Association of persistent morbidity after radiotherapy with quality of life in locally advanced cervical cancer survivors

Author

Spampinato, Sofia, Tanderup, Kari, Lindegaard, Jacob C., Schmid, Maximilian P., Sturdza, Alina, Segedin, Barbara, Jürgenliemk-Schulz, Ina M., De Leeuw, Astrid, Bruheim, Kjersti, Mahantshetty, Umesh, Chargari, Cyrus, Rai, Bhavana, Cooper, Rachel, van der Steen-Banasik, Elzbieta, Sundset, Marit, Wiebe, Ericka, Villafranca, Elena, Van Limbergen, Erik, Pieters, Bradley R., Tee Tan, Li, Lutgens, Ludy C.H.W., Hoskin, Peter, Smet, Stéphanie, Pötter, Richard, Nout, Remi, Chopra, Supriya, and Kirchheiner, Kathrin

Published
2023
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5. Prognostic Implications of Uterine Cervical Cancer Regression During Chemoradiation Evaluated by the T-Score in the Multicenter EMBRACE I Study

Author

Lindegaard, Jacob Christian, Petric, Primoz, Schmid, Maximilian Paul, Nesvacil, Nicole, Haie-Meder, Christine, Fokdal, Lars Ulrik, Sturdza, Alina Emiliana, Hoskin, Peter, Mahantshetty, Umesh, Segedin, Barbara, Bruheim, Kjersti, Huang, Fleur, Rai, Bhavana, Cooper, Rachel, van der Steen-Banasik, Elzbieta, Van Limbergen, Erik, Pieters, Bradley Rumwell, Tan, Li-Tee, Nout, Remi A., De Leeuw, Astrid Agatha Catharina, Kirchheiner, Kathrin, Spampinato, Sofia, Jürgenliemk-Schulz, Ina, Tanderup, Kari, Kirisits, Christian, and Pötter, Richard

Published
2022
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8. MRI-guided adaptive brachytherapy in locally advanced cervical cancer (EMBRACE-I): a multicentre prospective cohort study

Author

Chargari, Cyrus, Dumas, Isabelle, Lowe, Gerry, Swamidas, Jamema, Hudej, Robert, Paulsen Hellebust, Taran, Menon, Geetha, Oinam, Arun S., Bownes, Peter, Christiaens, Melissa, De Brabandere, Marisol, Janssen, Hilde, Oosterveld, Bernard, Koedooder, Kees, Langeland Marthinsen, Anne Beate, Sundset, Marit, Whitney, Diane, Ketelaars, Martijn, Lutgens, Ludy C.H.W., Reinniers, Brigitte, Mora, Itxa, Villafranca, Elena, Antal, Gergely, Hadjiev, Janaki, Bachand, Francois, Batchelar, Deidre, Erickson, Beth, Rownd, Jason, Jacobson, Geraldine, Kim, Yusung, Anttila, Maarit, Palmgren, Jan-Erik, An, Jusheng, Assenholt, Marianne Sanggaard, Banerjee, Susovan, Bentzen, Sören, Berger, Thomas, Dankulchai, Pittaya, Diendorfer, Tamara, Dilworth, Ian, Dimopoulos, Johannes, Dörr, Elke, Ecker, Stefan, Federico, Mario, Fidarova, Elena, Fortin, Israel, Georg, Petra, Gora, Joanna, Hegazy, Neamat, Jastaniyah, Noha, Jensen, Nina Boje Kibsgaard, Liederer, Thomas, Majercakova, Katarina, Misimovic, Dragan, Motisi, Laura, Najjari Jamal, Dina, Nkiwane, Karen, Schwartz-Vittrup, Anders, Serban, Monica, Smet, Stephanie, Spampinato, Sofia, Trnkova, Petra, Valgma, Margit, Westerveld, Henrike, Wong, Joyce Siu Yu, Yoshida, Kenji, Pötter, Richard, Tanderup, Kari, Schmid, Maximilian Paul, Jürgenliemk-Schulz, Ina, Haie-Meder, Christine, Fokdal, Lars Ulrik, Sturdza, Alina Emiliana, Hoskin, Peter, Mahantshetty, Umesh, Segedin, Barbara, Bruheim, Kjersti, Huang, Fleur, Rai, Bhavana, Cooper, Rachel, van der Steen-Banasik, Elzbieta, Van Limbergen, Erik, Pieters, Bradley Rumwell, Tan, Li-Tee, Nout, Remi Abubakar, De Leeuw, Astrid Agatha Catharina, Ristl, Robin, Petric, Primoz, Nesvacil, Nicole, Kirchheiner, Kathrin, Kirisits, Christian, and Lindegaard, Jacob Christian

Published
2021
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9. Initiatives for education, training, and dissemination of morbidity assessment and reporting in a multiinstitutional international context: Insights from the EMBRACE studies on cervical cancer

Author

Kirchheiner, Kathrin, Smet, Stéphanie, Spampinato, Sofia, Jensen, Nina B.K., Vittrup, Anders Schwartz, Fokdal, Lars, Najjari-Jamal, Dina, Westerveld, Henrike G., Lindegaard, Jacob C., Kirisits, Christian, De Leeuw, Astrid, Schmid, Maximilian P., Tan, Li Tee, Nout, Remi A., Jürgenliemk-Schulz, Ina M., Pötter, Richard, and Tanderup, Kari

Published
2020
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10. Education and training for image-guided adaptive brachytherapy for cervix cancer—The (GEC)-ESTRO/EMBRACE perspective

Author

Tan, Li-Tee, Tanderup, Kari, Kirisits, Christian, Mahantshetty, Umesh, Swamidas, Jamema, Jürgenliemk-Schulz, Ina, Lindegaard, Jacob, de Leeuw, Astrid, Nesvacil, Nicole, Assenholt, Marianne, Berger, Daniel, Diendorfer, Tamara, Dimopoulos, Johannes, Duke, Simon, Ecker, Stefan, Fokdal, Lars, Hellebust, Taran, Jensen, Nina, Kirchheiner, Kathrin, Nout, Remi, Petric, Primoz, Schmid, Maximilian, Seppenwoolde, Yvette, Sturdza, Alina, Van Limbergen, Erik, Haie-Meder, Christine, and Pötter, Richard

Published
2020
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11. Ring Versus Ovoids and Intracavitary Versus Intracavitary-Interstitial Applicators in Cervical Cancer Brachytherapy: Results From the EMBRACE I Study

Author

Serban, Monica, Kirisits, Christian, de Leeuw, Astrid, Pötter, Richard, Jürgenliemk-Schulz, Ina, Nesvacil, Nicole, Swamidas, Jamema, Hudej, Robert, Lowe, Gerry, Hellebust, Taran Paulsen, Menon, Geetha, Oinam, Arun, Bownes, Peter, Oosterveld, Bernard, De Brabandere, Marisol, Koedooder, Kees, Langeland Marthinsen, Anne Beate, Whitney, Diane, Lindegaard, Jacob, and Tanderup, Kari

Published
2020
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12. Importance of Technique, Target Selection, Contouring, Dose Prescription, and Dose-Planning in External Beam Radiation Therapy for Cervical Cancer: Evolution of Practice From EMBRACE-I to II

Author

Berger, Thomas, Seppenwoolde, Yvette, Pötter, Richard, Assenholt, Marianne Sanggaard, Lindegaard, Jacob C., Nout, Remi A., de Leeuw, Astrid, Jürgenliemk-Schulz, Ina, Tan, Li Tee, Georg, Dietmar, Kirisits, Christian, Dumas, Isabelle, Nesvacil, Nicole, Swamidas, Jamema, Hudej, Robert, Lowe, Gerry, Hellebust, Taran Paulsen, Menon, Geetha, Fokdal, Lars, and Tanderup, Kari

Published
2019
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13. Nodal failure after chemo-radiation and MRI guided brachytherapy in cervical cancer: Patterns of failure in the EMBRACE study cohort

Author

Nomden, Christel N., Pötter, Richard, de Leeuw, Astrid A.C., Tanderup, Kari, Lindegaard, Jacob C., Schmid, Maximilian P., Fortin, Israël, Haie-Meder, Christine, Mahantshetty, Umesh, Hoskin, Peter, Segedin, Barbara, Bruheim, Kjersti, Rai, Bhavana, Huang, Fleur, Cooper, Rachel, Van Der Steen Banasik, Elzbieta, Van Limbergen, Erik, and Jürgenliemk-Schulz, Ina M.

Published
2019
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17. Isodose surface volumes in cervix cancer brachytherapy: Change of practice from standard (Point A) to individualized image guided adaptive (EMBRACE I) brachytherapy

Author

Serban, Monica, Kirisits, Christian, Pötter, Richard, de Leeuw, Astrid, Nkiwane, Karen, Dumas, Isabelle, Nesvacil, Nicole, Swamidas, Jamema, Hudej, Robert, Lowe, Gerry, Hellebust, Taran Paulsen, Menon, Geetha, Oinam, Arun, Bownes, Peter, Oosterveld, Bernard, De Brabandere, Marisol, Koedooder, Kees, Marthinsen, Anne Beate Langeland, Lindegaard, Jacob, and Tanderup, Kari

Published
2018
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18. 127 Impact of Brachytherapy Applicator on Clinical Outcomes in Cervix Cancer: An EMBRACE-I Study Analysis

Author

Serban, Monica, primary, Spampinato, Sofia, additional, de Leeuw, Astrid, additional, Fortin, Israel, additional, Nesvacil, Nicole, additional, Kirisits, Christian, additional, Schmid, Maximilian, additional, Mahantshetty, Umesh, additional, Hoskin, Peter, additional, Segedin, Barbara, additional, Bruheim, Kjersti, additional, Huang, Fleur, additional, Pieters, Bradley, additional, Nout, Remi, additional, Pötter, Richard, additional, Kirchheiner, Kathrin, additional, Jürgenliemk-Schulz, Ina, additional, and Tanderup, Kari, additional

Published
2023
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19. 890: Impact of cumulative cisplatin-dose on distant metastasis after chemoradiation of cervical cancer

Author

Knoth, Johannes, Nout, Remi, Mahantshetty, Umesh, Jürgenliemk-Schulz, Ina, Haie-Meder, Christine, Fokdal, Lars U., Sturdza, Alina, Hoskin, Peter, Segedin, Barbara, Bruheim, Kjersti, Huang, Fleur, Rai, Bhavana, Cooper, Rachel, van der Steen-Banasik, Elzbieta, van Limbergen, Erik, Pieters, Bradley R., Tan, Li T., Boryshchuk, Daniela, de Leeuw, Astrid A.C., Nesvacil, Nicole, Tanderup, Kari, Kirisits, Christian, Lindegaard, Jacob C., Pötter, Richard, and Schmid, Maximilian P.

Published
2024
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20. The EMBRACE II study: The outcome and prospect of two decades of evolution within the GEC-ESTRO GYN working group and the EMBRACE studies

Author

Pötter, Richard, Tanderup, Kari, Kirisits, Christian, de Leeuw, Astrid, Kirchheiner, Kathrin, Nout, Remi, Tan, Li Tee, Haie-Meder, Christine, Mahantshetty, Umesh, Segedin, Barbara, Hoskin, Peter, Bruheim, Kjersti, Rai, Bhavana, Huang, Fleur, Van Limbergen, Erik, Schmid, Max, Nesvacil, Nicole, Sturdza, Alina, Fokdal, Lars, Jensen, Nina Boje Kibsgaard, Georg, Dietmar, Assenholt, Marianne, Seppenwoolde, Yvette, Nomden, Christel, Fortin, Israel, Chopra, Supriya, van der Heide, Uulke, Rumpold, Tamara, Lindegaard, Jacob Christian, and Jürgenliemk-Schulz, Ina

Published
2018
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24. Tools for large-scale data analytics of an international multi-center study in radiation oncology for cervical cancer

Author

Klinische Fysica RT, Cancer, MS Radiotherapie, Ecker, Stefan, Kirisits, Christian, Schmid, Maximilian, De Leeuw, Astrid, Seppenwoolde, Yvette, Knoth, Johannes, Trnkova, Petra, Heilemann, Gerd, Sturdza, Alina, Kirchheiner, Kathrin, Spampinato, Sofia, Serban, Monica, Jürgenliemk-Schulz, Ina, Chopra, Supriya, Nout, Remi, Tanderup, Kari, Pötter, Richard, Eder-Nesvacil, Nicole, Klinische Fysica RT, Cancer, MS Radiotherapie, Ecker, Stefan, Kirisits, Christian, Schmid, Maximilian, De Leeuw, Astrid, Seppenwoolde, Yvette, Knoth, Johannes, Trnkova, Petra, Heilemann, Gerd, Sturdza, Alina, Kirchheiner, Kathrin, Spampinato, Sofia, Serban, Monica, Jürgenliemk-Schulz, Ina, Chopra, Supriya, Nout, Remi, Tanderup, Kari, Pötter, Richard, and Eder-Nesvacil, Nicole

Published
2023

25. EviGUIDE - a tool for evidence-based decision making in image-guided adaptive brachytherapy for cervical cancer

Author

Klinische Fysica RT, Cancer, MS Radiotherapie, Ecker, Stefan, Kirisits, Christian, Schmid, Maximilian, Knoth, Johannes, Heilemann, Gerd, De Leeuw, Astrid, Sturdza, Alina, Kirchheiner, Kathrin, Jensen, Nina, Nout, Remi, Jürgenliemk-Schulz, Ina, Pötter, Richard, Spampinato, Sofia, Tanderup, Kari, Eder-Nesvacil, Nicole, Klinische Fysica RT, Cancer, MS Radiotherapie, Ecker, Stefan, Kirisits, Christian, Schmid, Maximilian, Knoth, Johannes, Heilemann, Gerd, De Leeuw, Astrid, Sturdza, Alina, Kirchheiner, Kathrin, Jensen, Nina, Nout, Remi, Jürgenliemk-Schulz, Ina, Pötter, Richard, Spampinato, Sofia, Tanderup, Kari, and Eder-Nesvacil, Nicole

Published
2023

26. Multi-center dosimetric predictions to improve plan quality for brachytherapy for cervical cancer treatment

Author

Klinische Fysica RT, Cancer, MS Radiotherapie, Reijtenbagh, Dominique M W, Godart, Jérémy, de Leeuw, Astrid A C, Jürgenliemk-Schulz, Ina M, Mens, Jan-Willem M, Huge, Michèle, Hoogeman, Mischa S, Klinische Fysica RT, Cancer, MS Radiotherapie, Reijtenbagh, Dominique M W, Godart, Jérémy, de Leeuw, Astrid A C, Jürgenliemk-Schulz, Ina M, Mens, Jan-Willem M, Huge, Michèle, and Hoogeman, Mischa S

Published
2023

29. Health-Related Quality of Life in Locally Advanced Cervical Cancer Patients After Definitive Chemoradiation Therapy Including Image Guided Adaptive Brachytherapy: An Analysis From the EMBRACE Study

Author

Lindegaard, Jacob, Tanderup, Kari, Fokdal, Lars, Van Der Steen Banasik, Elzbieta, Haie-Meder, Christine, Dumas, Isabelle, Chargari, Cyrus, Nout, Remi A., Van Limbergen, Erik, Petrič, Primož, Segedin, Barbara, Hudej, Robert, Erickson, Beth, Hoskin, Peter, Lowe, Gerry, Mahantshetty, Umesh, Swamidas, Jamema, Shrivastava, Shyam Kishore, Jürgenliemk-Schulz, Ina M., De Leeuw, Astrid, Kirchheiner, Kathrin, Dörr, Wolfgang, Pötter, Richard, Lutgens, Ludy C.H.W., Hadjiev, Janaki, Cooper, Rachel, Bownes, Peter, Sundset, Marit, Bruheim, Kjersti, Hellebust, Taran Paulsen, Huang, Fleur, Menon, Geetha, Villafranca, Elena, Rai, Bhavana, Oinam, Arun S., Tan, Li Tee, Bachand, Francois, Jacobson, Geraldine, Anttila, Maarit, Pieters, Bradley, and Lindegaard, Jacob C.

Published
2016
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30. Risk Factors for Local Failure Following Chemoradiation and Magnetic Resonance Image-Guided Brachytherapy in Locally Advanced Cervical Cancer: Results From the EMBRACE-I Study

Author

Schmid, Maximilian P., Lindegaard, Jacob C., Mahantshetty, Umesh, Tanderup, Kari, Jürgenliemk-Schulz, Ina, Haie-Meder, Christine, Fokdal, Lars U., Sturdza, Alina, Hoskin, Peter, Segedin, Barbara, Bruheim, Kjersti, Huang, Fleur, Rai, Bhavana, Cooper, Rachel, van der Steen-Banasik, Elzbieta, Van Limbergen, Erik, Pieters, Bradley R., Petric, Primoz, Ramazanova, Dariga, Ristl, Robin, Kannan, Sadhana, Hawaldar, Rohini, Ecker, Stefan, Kirchheiner, Kathrin, Tan, Li Tee, Nout, Remi, Nesvacil, Nicole, de Leeuw, Astrid, Pötter, Richard, Kirisits, Christian, Radiotherapy, CCA - Cancer Treatment and Quality of Life, and CCA - Imaging and biomarkers

Subjects
Cancer Research, Oncology
Abstract

PURPOSE To report clinical and treatment characteristics, remission and failure patterns, and risk factors for local failure (LF) from the EMBRACE-I study. MATERIALS AND METHODS EMBRACE-I was a prospective, observational, multicenter cohort study on magnetic resonance imaging–based image-guided adaptive brachytherapy (MR-IGABT) in locally advanced cervical cancer. Treatment consisted of external beam radiotherapy, concurrent chemotherapy, and MR-IGABT. LF was defined as progressive or recurrent disease in the cervix, uterus, parametria, pelvic wall, or vagina. Competing risk analysis was used to estimate local tumor control (LC) and Cox proportional regression models for multivariable analysis and dose-response analysis. RESULTS One thousand three hundred eighteen patients with a median follow-up of 52 months were available for this analysis. Eighty-one patients had persistent disease 3 months after end of treatment. Of those, 60 patients achieved LC at 6-9 months without further treatment, whereas 21 patients had progressive disease. In addition, 77 patients developed a local recurrence after complete remission comprising a total number of 98 LFs. LFs were located inside the MR-IGABT target volumes in 90% of patients with LF. In multivariable analysis, histology, minimal dose to 90% of high-risk clinical target volume (CTVHR), maximum tumor dimension, CTVHR > 45 cm3, overall treatment time, tumor necrosis on magnetic resonance imaging at diagnosis, uterine corpus infiltration at diagnosis and at MR-IGABT, and mesorectal infiltration at MR-IGABT had significant impact on LF. Dose-response analysis showed that a minimal dose to 90% of 85 Gy to the CTVHR led to 95% (95% CI, 94 to 97) LC 3 years postintervention for squamous cell in comparison to 86% (95% CI, 81 to 90) for adeno/adenosquamous carcinoma histology. CONCLUSION The present study demonstrates the safety and validity of the GYN GEC-ESTRO/ICRU-89 target concept and provides large-scale evidence for dose prescription and new risk factors for LF in MR-IGABT in locally advanced cervical cancer.

Published
2023

32. Free-Form Registration Involving Disappearing Structures: Application to Brachytherapy MRI

Author

Berendsen, Floris F., Kotte, Alexis N. T. J., de Leeuw, Astrid A. C., Viergever, Max A., Pluim, Josien P. W., Hutchison, David, editor, Kanade, Takeo, editor, Kittler, Josef, editor, Kleinberg, Jon M., editor, Mattern, Friedemann, editor, Mitchell, John C., editor, Naor, Moni, editor, Nierstrasz, Oscar, editor, Pandu Rangan, C., editor, Steffen, Bernhard, editor, Sudan, Madhu, editor, Terzopoulos, Demetri, editor, Tygar, Doug, editor, Vardi, Moshe Y., editor, Weikum, Gerhard, editor, Yoshida, Hiroyuki, editor, Warfield, Simon, editor, and Vannier, Michael W., editor

Published
2013
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42. Dose-effect relationship between vaginal dose points and vaginal stenosis in cervical cancer:An EMBRACE-I sub-study

Author

Westerveld, Henrike, Kirchheiner, Kathrin, Nout, Remi A., Tanderup, Kari, Lindegaard, Jacob C., Spampinato, Sofia, Sturdza, Alina, Nesvacil, Nicole, Bruheim, Kjersti, Hellebust, Taran P., Pieters, Bradley R., Kirisits, Christian, Jürgenliemk-Schulz, Ina M., Pötter, Richard, de Leeuw, Astrid A.C., Radiation Oncology, CCA - Cancer Treatment and Quality of Life, and Radiotherapy

Subjects
Radiotherapy, PIBS, Brachytherapy, RV-RP, Uterine Cervical Neoplasms, Radiotherapy Dosage, Constriction, Pathologic, Hematology, Vaginal morbidity, EMBRACE, SDG 3 - Good Health and Well-being, Oncology, ICRU-R, Vagina, Cervical cancer, Humans, Female, Radiology, Nuclear Medicine and imaging, Dose-effect
Abstract

Background and purpose: To evaluate dose–effect relationships between vaginal dose points and vaginal stenosis in patients treated for locally advanced cervical cancer with radio(chemo)therapy and image-guided adaptive brachytherapy. Material and methods: Patients from six centres participating in the EMBRACE-I study were included. Information on doses to different vaginal dose points, including the Posterior-Inferior Border of Symphysis (PIBS) points and recto-vaginal reference (RV-RP) point, were retrieved from the treatment planning system. In addition, the vaginal reference length (VRL) was evaluated. Vaginal stenosis was prospectively assessed according to the CTCAEv3.0 system at baseline and follow-up. Primary endpoint was grade 2 or higher (G ≥ 2) vaginal stenosis. Impact of dose to the vaginal dose points, and impact of VRL, age, vaginal involvement and applicator on vaginal stenosis G ≥ 2 was evaluated with a Cox proportional-hazard regression model. Results: 301 patients were included. Median follow-up was 49 months. During follow-up, the incidence of G0, G1, G2, and G3 vaginal stenosis was 25% (76), 52% (158), 20% (59) and 3% (8), respectively. Median total doses to PIBS+2 cm, PIBS, PIBS-2 cm and the RV-RP were 52.9 (IQR 49.3–64.7), 41.0 (IQR 15.4–49.0), 4.1 (IQR 2.9–7.0) and 64.6 (IQR 60.0–70.6) Gy EQD23, respectively. Higher doses to the PIBS, PIBS + 2 cm and RV-RP points were significantly associated with increased risk for vaginal stenosis G ≥ 2. Other risk factors for vaginal stenosis were: vaginal involvement at diagnosis, higher age, shorter VRL and use of a tandem-ovoid applicator. Conclusion: Higher doses to the PIBS+2 cm, PIBS and RV-RP dose points are associated with vaginal stenosis G ≥ 2.

Published
2022

43. Multi-center analysis of machine-learning predicted dose parameters in brachytherapy for cervical cancer

Author

Reijtenbagh, Dominique, Godart, Jérémy, de Leeuw, Astrid, Seppenwoolde, Yvette, Jürgenliemk-Schulz, Ina, Mens, Jan Willem, Nout, Remi, Hoogeman, Mischa, Reijtenbagh, Dominique, Godart, Jérémy, de Leeuw, Astrid, Seppenwoolde, Yvette, Jürgenliemk-Schulz, Ina, Mens, Jan Willem, Nout, Remi, and Hoogeman, Mischa

Abstract

Background and purpose: Image-guided adaptive brachytherapy (IGABT) is a key component in the treatment of cervical cancer, but the nature of the clinical workflow makes it vulnerable to suboptimal plans, as the theoretical optimal plan depends heavily on organ configuration. Patient anatomy-based quality-assurance (QA) with overlap volume histograms (OVHs) is a promising tool to detect such suboptimal plans, and in this analysis its suitability as a multi-institutional clinical QA tool is investigated. Materials and methods: A total of 223 plans of 145 patients treated in accordance with the current state-of-the-art IGABT protocols from UMC Utrecht (UMCU) and Erasmus MC (EMC) were included. Machine-learning models were trained to predict dose D2cm3 to bladder, rectum, sigmoid and small bowel with the help of OVHs. For this strategy, points are sampled on the organs-at-risk (OARs), and the distances of the sampled points to the target are computed and combined in a histogram. Machine-learning models can then be trained to predict dose-volume histograms (DVHs) for unseen data. Single-center model robustness to needle use and applicator type and multi-center model translatability were investigated. Performance of models was assessed by the difference between planned (clinical) and predicted D2cm3 values. Results: Intra-validation of UMCU data demonstrated OVH model robustness to needle use and applicator type. The model trained on UMCU data was found to be robust within the same protocol on EMC data, for all investigated OARs. Mean squared error between planned and predicted D2cm3 values of OARs ranged between 0.13 and 0.40 Gy within the same protocol, indicating model translatability. For the former protocol cohort of Erasmus MC large deviations were found between the planned and predicted D2cm3 values, indicating plan deviation from protocol. Mean squared error for this cohort ranged from 0.84 to 4.71 Gy. Conclusion: OV

Published
2022

44. Prognostic Implications of Uterine Cervical Cancer Regression During Chemoradiation Evaluated by the T-Score in the Multicenter EMBRACE I Study

Author

Cancer, Klinische Fysica RT, MS Radiotherapie, Lindegaard, Jacob Christian, Petric, Primoz, Schmid, Maximilian Paul, Nesvacil, Nicole, Haie-Meder, Christine, Fokdal, Lars Ulrik, Sturdza, Alina Emiliana, Hoskin, Peter, Mahantshetty, Umesh, Segedin, Barbara, Bruheim, Kjersti, Huang, Fleur, Rai, Bhavana, Cooper, Rachel, van der Steen-Banasik, Elzbieta, Van Limbergen, Erik, Pieters, Bradley Rumwell, Tan, Li Tee, Nout, Remi A., De Leeuw, Astrid Agatha Catharina, Kirchheiner, Kathrin, Spampinato, Sofia, Jürgenliemk-Schulz, Ina, Tanderup, Kari, Kirisits, Christian, Pötter, Richard, Cancer, Klinische Fysica RT, MS Radiotherapie, Lindegaard, Jacob Christian, Petric, Primoz, Schmid, Maximilian Paul, Nesvacil, Nicole, Haie-Meder, Christine, Fokdal, Lars Ulrik, Sturdza, Alina Emiliana, Hoskin, Peter, Mahantshetty, Umesh, Segedin, Barbara, Bruheim, Kjersti, Huang, Fleur, Rai, Bhavana, Cooper, Rachel, van der Steen-Banasik, Elzbieta, Van Limbergen, Erik, Pieters, Bradley Rumwell, Tan, Li Tee, Nout, Remi A., De Leeuw, Astrid Agatha Catharina, Kirchheiner, Kathrin, Spampinato, Sofia, Jürgenliemk-Schulz, Ina, Tanderup, Kari, Kirisits, Christian, and Pötter, Richard

Published
2022

45. Multi-center analysis of machine-learning predicted dose parameters in brachytherapy for cervical cancer

Author

Cancer, Klinische Fysica RT, MS Radiotherapie, Reijtenbagh, Dominique, Godart, Jérémy, de Leeuw, Astrid, Seppenwoolde, Yvette, Jürgenliemk-Schulz, Ina, Mens, Jan Willem, Nout, Remi, Hoogeman, Mischa, Cancer, Klinische Fysica RT, MS Radiotherapie, Reijtenbagh, Dominique, Godart, Jérémy, de Leeuw, Astrid, Seppenwoolde, Yvette, Jürgenliemk-Schulz, Ina, Mens, Jan Willem, Nout, Remi, and Hoogeman, Mischa

Published
2022

46. Dose-effect relationship between vaginal dose points and vaginal stenosis in cervical cancer: An EMBRACE-I sub-study

Author

MS Radiotherapie, Cancer, Klinische Fysica RT, Westerveld, Henrike, Kirchheiner, Kathrin, Nout, Remi A., Tanderup, Kari, Lindegaard, Jacob C., Spampinato, Sofia, Sturdza, Alina, Nesvacil, Nicole, Bruheim, Kjersti, Hellebust, Taran P., Pieters, Bradley R., Kirisits, Christian, Jürgenliemk-Schulz, Ina M., Pötter, Richard, de Leeuw, Astrid A.C., MS Radiotherapie, Cancer, Klinische Fysica RT, Westerveld, Henrike, Kirchheiner, Kathrin, Nout, Remi A., Tanderup, Kari, Lindegaard, Jacob C., Spampinato, Sofia, Sturdza, Alina, Nesvacil, Nicole, Bruheim, Kjersti, Hellebust, Taran P., Pieters, Bradley R., Kirisits, Christian, Jürgenliemk-Schulz, Ina M., Pötter, Richard, and de Leeuw, Astrid A.C.

Published
2022

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