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40 results on '"De Lange D.W."'

1. Application of European Society of Cardiology guidelines for evaluating acute coronary syndrome risk in low-risk patients with cocaine-associated chest pain: Findings from the RISK study – An observational analysis

Author: Gresnigt, F.M.J., Heikamp, L.K., van Essen, J.J.W., Walraven, L.F.J., van Ofwegen-Hanekamp, C.E.E., Mollink, S., Franssen, E.J.F., de Lange, D.W., and Riezebos, R.K.
Published: 2024
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2. High PEEP/low FiO2 ventilation is associated with lower mortality in COVID–19

Author: Ahuja, S., van Akkeren, J.P., Algera, A.G., Algoe, C.K., van Amstel, R.B., Artigas, A., Aydeniz, E., Bailey, M., van den Berg, A.E., van de Berg, P., Bergmans, D.C.J.J., van den Bersselaar, D.I., Bertens, F.A., Bevers, M., Bindels, A.J.G.H., Breel, J.S., de Bruin, S., Bruna, C.L., de Boer, M., Boer, D.P., den Boer, S., Boers, L.S., Bogerd, M.B., Bos, L.D., Bosman, B., Botta, M., de Bie, A.J.R., Baur, O.L., Buiteman-Kruizinga, L.A., Coene, W., Cremer, O.L., Daenen, K., Delmte, M., Determann, R.M., Dieperink, W., Di Leo, V., van Dijk, J., Dongelmans, D.A., Dormans, T., Endeman, H., Elting, L.M., Esmeijer, A.A., Filippini, D., Flim, J.M., Franke, H.S., Galek-aldridge, M.S., de Abreu, M.G. Gama, Girbes, A.R., Go, D.M., Goossen, R.L., de Graaff, M.J., Hagens, L.A., Hansen, H.J., Haringman, J.J., van der Heide, S.T., van der Heiden, P.L.J., Heijnen, N.F.L., Hiel, S.J.P., Hoeijmakers, L.L., Hol, L., Hollmann, M.W., Hoogendoorn, M.E., Horn, J., van der Horst, I., van der Horst, R., Huijben, J.A., Ie, E.L.K., van Ingen, L.E., Ivanov, D.P., Juffermans, N.P., Kranen, H.T., Kho, E., de Klerk, E.S., Koek, N., Gemert, A.W.M.M. Koopman-van, Koopmans, M., Kucukcelebi, S., Kuiper, M.A., Kuipers, L.J., Koornstra, E., Lokhorst, A., de Lange, D.W., Martin-Loeches, I., van Meenen, D.M.P., Mazzinari, G., Moeniralam, H., van Mourik, N., Myatra, S.N., Nijbroek, S.G., van Oosten, P., Offermans, M., Onrust, M., Oostdijk, E.A.N., Paulus, F., Pennartz, C.J., Peršec, J., Peters, V.J.T., Pillay, J.J., Pisani, L., Pisters, T., Prins, A., Purmer, I.M., Rettig, T.C.D., Rezaee, A.S., Roca, O., Roozeman, J., Rozendaal, J., Rosenberg, N.M., Schavemaker, R., Sciascera, A., Schuijt, M.T.U., Schultz, M.J., Neto, A.S. Serpa, Shrestha, G.S., van Silfhout, B., Sjoding, M., Sleeswijk, M.E., van Smaalen, K.M., Smit, M.R., Spronk, P.E., Šribar, A., Strang, A.C., Stilma, W., Swart, P., Tuinman, P.R., Tsonas, A.M., den Uil, C.A., Valk, C.M.A., Veen-Schra, F.L., Vlaar, A.P.J., Veldhuis, L.I., van der Ven, W.H., van der Ven, F.L.I.M., van Velzen, P., Verboom, M., Verhoef, E.J., Vermeulen, T.D., van Vliet, P., van Vliet, R., Voorham, J.S., van der Voort, P.H.J., van Welie, L., Weller, D., Wentink, A.R., Wesselink, H.J.F.T., van der Wier-Lubbers, H., van Wijk, B., van Willigen, H., van der Woude, M.C.E., Weiner, J.J., Winters, T., Wong, W.Y., Yaali, N., Zandvliet, J.M., van Zanten, A.R.H., van Zijl, T.Z.I., Zonneveld, S.A., Goossen, Robin L., van Vliet, Relin, Bos, Lieuwe D.J., Buiteman-Kruizinga, Laura A., Hollman, Markus W., Myatra, Sheila N., Neto, Ary Serpa, Spronk, Peter E., van der Woude, Meta C.E., van Meenen, David M.P., Paulus, Frederique, and Schultz, Marcus J.
Published: 2024
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3. Automated identification of patient subgroups: A case-study on mortality of COVID-19 patients admitted to the ICU

Author: Arbous, M.S., Verbiest, D.P., Velde, L.F. te, van Driel, E.M., Rijpstra, T., Elbers, P.W.G., Houwink, A.P.I., Georgieva, L., Verweij, E., de Jong, R.M., van Iersel, F.M., Koning, T.J.J., Rengers, E., Kusadasi, N., Erkamp, M.L., van den Berg, R., Jacobs, C.J.M.G., Epker, J.L., Rijkeboer, A.A., de Bruin, M.T., Spronk, P., Draisma, A., Versluis, D.J., van den Berg, A.E., Vrolijk-de Mos, M., Lens, J.A., Pruijsten, R.V., Kieft, H., Rozendaal, J., Nooteboom, F., Boer, D.P., Janssen, I.T.A., van Gulik, L., Koetsier, M.P., Silderhuis, V.M., Schnabel, R.M., Drogt, I., de Ruijter, W., Bosman, R.J., Frenzel, T., Urlings-Strop, L.C., Dijkhuizen, A., Hené, I.Z., de Meijer, A.R., Holtkamp, J.W.M., Postma, N., Bindels, A.J.G.H., Wesselink, R.M.J., van Slobbe-Bijlsma, E.R., van der Voort, P.H.J., Eikemans, B.J.W., Mehagnoul-Schipper, D.J., Gommers, D., Lutisan, J.G., Hoeksema, M., Barnas, M.G.W., Festen-Spanjer, B., van Lieshout, M., Gritters, N.C., van Tellingen, M., Brunnekreef, G.B., Vandeputte, J., Dormans, T.P.J., Hoogendoorn, M.E., de Graaff, M., Moolenaar, D., Reidinga, A.C., Spijkstra, J.J., de Waal, R., Ramnarain, D., van Oers, J.H.A., Vagliano, I., Kingma, M.Y., Dongelmans, D.A., de Lange, D.W., de Keizer, N.F., and Schut, M.C.
Published: 2023
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4. Can we reliably automate clinical prognostic modelling? A retrospective cohort study for ICU triage prediction of in-hospital mortality of COVID-19 patients in the Netherlands

Author: Vagliano, I., Brinkman, S., Abu-Hanna, A., Arbous, M.S, Dongelmans, D.A., Elbers, P.W.G., de Lange, D.W., van der Schaar, M., de Keizer, N.F., and Schut, M.C.
Published: 2022
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5. Comparison of outcome and characteristics between 6343 COVID-19 patients and 2256 other community-acquired viral pneumonia patients admitted to Dutch ICUs

Author: Verbiest, D.P., te Velde, L.F., van Driel, E.M., Rijpstra, T., Elbers, P.W.G., Houwink, A.P.I., Georgieva, L., Verweij, E., de Jong, R.M., van Iersel, F.M., Koning, T.J.J., Rengers, E., Kusadasi, N., Erkamp, M.L., van den Berg, R., Jacobs, C.J.M.G., Epker, J.L., Rijkeboer, A.A., de Bruin, M.T., Spronk, P., Draisma, A., Versluis, D.J., van den Berg, A.E., Mos, M. Vrolijk-de, Lens, J.A., Pruijsten, R.V., Kieft, H., Rozendaal, J., Nooteboom, F., Boer, D.P., Janssen, I.T.A., van Gulik, L., Koetsier, M.P., Silderhuis, V.M., Schnabel, R.M., Drogt, I., de Ruijter, W., Bosman, R.J., Frenzel, T., Urlings-Strop, L.C., Dijkhuizen, A., Hené, I.Z., de Meijer, A.R., Holtkamp, J.W.M., Postma, N., Bindels, A.J.G.H., Wesselink, R.M.J., van Slobbe-Bijlsma, E.R., van der Voort, P.H.J., Eikemans, B.J.W., Mehagnoul-Schipper, D.J., Gommers, D., Lutisan, J.G., Hoeksema, M., Barnas, M.G.W., Festen-Spanjer, B., van Lieshout, M., Gritters, N.C., van Tellingen, M., Brunnekreef, G.B., Vandeputte, J., Dormans, T.P.J., Hoogendoorn, M.E., de Graaff, M., Moolenaar, D., Reidinga, A.C., Spijkstra, J.J., de Waal, R., Brinkman, S., Termorshuizen, F., Dongelmans, D.A., Bakhshi-Raiez, F., Arbous, M.S., de Lange, D.W., and de Keizer, N.F.
Published: 2022
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6. Prognostication using SpO2/FiO2 in invasively ventilated ICU patients with ARDS due to COVID-19 – Insights from the PRoVENT-COVID study

Author: Algera, A.G., Boers, L.S., Bos, L.D.J., Botta, M., Dongelmans, D.A., Hollmann, M.W., Horn, J., Paulus, F., Pillay, J., Schultz, M.J., Neto, A. Serpa, Tsonas, A.M., Vlaar, A.P.J., Ahuja, S., van Akkeren, J.P., Algoe, C.K., van Amstel, R.B., Artigas, A., Baur, O.L., van de Berg, P., van den Berg, A.E., Bergmans, D.C.J.J., van den Bersselaar, D.I., Bertens, F.A., Bindels, A.J.G.H., de Boer, M.M., den Boer, S., Bogerd, M., Breel, J.S., de Bruin, H., de Bruin, S., Bruna, C.L., Buiteman-Kruizinga, L.A., Cremer, O.L., Determann, R.M., Dieperink, W., Franke, H.S., Galek-Aldridge, M.S., de Graaff, M.J., Hagens, L.A., Haringman, J.J., van der Heide, S.T., van der Heiden, P.L.J., Heijnen, N.F.L., Hiel, S.J.P., Hoeijmakers, L.L., Hol, L., Hoogendoorn, M.E., van der Horst, R., Ie, E.L.K., Ivanov, D., Juffermans, N.P., Kho, E., de Klerk, E.S., Gemert, A.W.M.M. Koopman-van, Koopmans, M., Kucukcelebi, S., Kuiper, M.A., de Lange, D.W., van Mourik, N., Nijbroek, S.G., Onrust, M., Oostdijk, E.A.N., Pennartz, C.J., Pisani, L., Purmer, I.M., Rettig, T.C.D., Roozeman, J.P., Schuijt, M.T.U., Sleeswijk, M.E., Smit, M.R., Spronk, P.E., Stilma, W., Strang, A.C., Tuinman, P.R., Valk, C.M.A., Veen-Schra, F.L., Veldhuis, L.I., van Velzen, P., van der Ven, W.H., van Vliet, P., van der Voort, P.H.J., van Welie, L., Wesselink, H.J.F.T., van der Wier-Lubbers, H.H., van Wijk, B., Winters, T., Wong, W.Y., van Zanten, A.R.H., Roozeman, Jan-Paul, Mazzinari, Guido, Serpa Neto, Ary, Hollmann, Markus W., Paulus, Frederique, Schultz, Marcus J., and Pisani, Luigi
Published: 2022
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7. Longitudinal respiratory subphenotypes in patients with COVID-19-related acute respiratory distress syndrome: results from three observational cohorts

Author: van Akkeren, J.P., Algera, A.G., Algoe, C.K., van Amstel, R.B., Artigas, A., Baur, O.L., van de Berg, P., van den Berg, A.E., Bergmans, D.C.J.J., van den Bersselaar, D.I., Bertens, F.A., Bindels, A.J.G.H., de Boer, M.M., den Boer, S., Boers, L.S., Bogerd, M., Bos, L.D.J., Botta, M., Breel, J.S., de Bruin, H., de Bruin, S., Bruna, C.L., Buiteman-Kruizinga, L.A., Cremer, O., Determann, R.M., Dieperink, W., Dongelmans, D.A., Franke, H.S., Galek-Aldridge, M.S., de Graaff, M.J., Hagens, L.A., Haringman, J.J., van der Heide, S.T., van der Heiden, P.L.J., Heijnen, N.F.L., Hiel, S.J.P., Hoeijmakers, L.L., Hol, L., Hollmann, M.W., Hoogendoorn, M.E., Horn, J., van der Horst, R., Ie, E.L.K., Ivanov, D., Juffermans, N.P., Kho, E., de Klerk, E.S., Koopman-van Gemert, A.W.M.M., Koopmans, M., Kucukcelebi, S., Kuiper, M.A., de Lange, D.W., Martin-Loeches, I., Mazzinari, G., van Meenen, D.M.P., Morales-Quinteros, L., van Mourik, N., Nijbroek, S.G., Onrust, M., Oostdijk, E.A.N., Paulus, F., Pennartz, C.J., Pillay, J., Pisani, L., Purmer, I.M., Rettig, T.C.D., Roozeman, J.P., Schuijt, M.T.U., Schultz, M.J., Serpa Neto, A., Sleeswijk, M.E., Smit, M.R., Spronk, P.E., Stilma, W., Strang, A.C., Tsonas, A.M., Tuinman, P.R., Valk, C.M.A., Veen-Schra, F.L., Veldhuis, L.I., van Velzen, P., van der Ven, W.H., Vlaar, A.P.J., van Vliet, P., van der Voort, P.H.J., van Welie, L., Wesselink, H.J.F.T., van der Wier-Lubbers, H.H., van Wijk, B., Winters, T., Wong, W.Y., van Zanten, A.R.H., Bos, Lieuwe D J, Sjoding, Michael, Sinha, Pratik, Bhavani, Sivasubramanium V, Lyons, Patrick G, Bewley, Alice F, Botta, Michela, Tsonas, Anissa M, Serpa Neto, Ary, Schultz, Marcus J, Dickson, Robert P, and Paulus, Frederique
Published: 2021
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8. Mortality associated with early changes in ARDS severity in COVID–19 patients – Insights from the PRoVENT–COVID study

Author: van Akkeren, J.P., Algera, A.G., Algoe, C.K., van Amstel, R.B., Baur, O.L., van de Berg, P., van den Berg, A.E., Bergmans, D.C.J.J., van den Bersselaar, D.I., Bertens, F.A., Bindels, A.J.G.H., de Boer, M.M., den Boer, S., Boers, L.S., Bogerd, M., Bos, L.D.J., Botta, M., Breel, J.S., de Bruin, H., de Bruin, S., Bruna, C.L., Buiteman-Kruizinga, L.A., Cremer, O., Determann, R.M., Dieperink, W., Dongelmans, D.A., Franke, H.S., Aldridge, M.S. Galek, de Graaff, M.J., Hagens, L.A., Haringman, J.J., Heijnen, N.F.L., Hiel, S., van der Heide, S.T., van der Heiden, P.L.J., Hoeijmakers, L.L., Hol, L., Hollmann, M.W., Hoogendoorn, M.E., Horn, J., van der Horst, R., Ie, E.L.K., Ivanov, D., Juffermans, N.P., Kho, E., de Klerk, E.S., Koopman, A.W.M., Koopmans, M., Kucukcelebi, S., Kuiper, M.A., de Lange, D.W., van Mourik, N., Martin-Loeches, I., Nijbroek, S.G., Onrust, M., Oostdijk, E.A.N., Paulus, F., Pennartz, C.J., Pillay, J., Pisani, L., Purmer, I.M., Rettig, T.C.D., Roozeman, J.P., Schuijt, M.T.U., Schultz, M.J., Neto, A. Serpa, Sleeswijk, M.E., Smit, M.R., Spronk, P.E., Stilma, W., Strang, A.C., Tsonas, A.M., Tuinman, P.R., Valk, C.M.A., Veen, F.L., Vlaar, A.P.J., Veldhuis, L.I., van Velzen, P., van der Ven, W.H., van Vliet, P., van der Voort, P., van der Wier, H.H., van Welie, L., Wesselink, H.J.F.T., van Wijk, B., Winters, T., Wong, W.Y., van Zanten, A.R.H., Schuijt, Michiel T.U., Martin-Loeches, Ignacio, Schultz, Marcus J., Paulus, Frederique, and Neto, Ary Serpa
Published: 2021
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9. Performance of existing definitions and tests for the diagnosis of invasive aspergillosis in critically ill, adult patients: A systematic review with qualitative evidence synthesis

Author: Akova, M., Alastruey-Izquierdo, A., Arikan-Akdagli, S., Azoulay, E., Blot, S., Cornely, O.A., Lass-Flörl, C., Koehler, P., Cuenca-Estrella, M., de Lange, D.W., De Rosa, F.G., De Waele, J.J., Dimopoulos, G., Garnacho-Montero, J., Hoenigl, M., Kanj, S.S., Lamoth, F., Maertens, J., Martin-Loeches, I., Muñoz, P., Kullberg, B.J., Agvald-Ohman, C., Poulakou, G., Rello, J., Righi, E., Sanguinetti, M., Taccone, F.S., Timsit, J-F., Torres, A., Vazquez, J.A., Wauters, J., Calandra, T., Asperges, E., Tejada, S., Lebihan, C., Karaiskos, I., Peghin, M., Mortensen, K.L., Vena, A., Cortegiani, A., Mercier, T., Bassetti, M., Giacobbe, D.R., Grecchi, C., Rebuffi, C., Zuccaro, V., and Scudeller, L.
Published: 2020
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10. Outcome of very old patients admitted to the ICU for sepsis: A systematic review

Author: Haas, L.E.M., van Dillen, L.S., de Lange, D.W., van Dijk, D., and Hamaker, M.E.
Published: 2017
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11. Performance of existing definitions and tests for the diagnosis of invasive aspergillosis in critically ill, non-neutropenic, adult patients: An update including COVID-19 data

Author: Bassetti, Matteo, primary, Zuccaro, Valentina, additional, Asperges, Erika, additional, Scudeller, Luigia, additional, Giacobbe, Daniele Roberto, additional, Akova, M., additional, Alastruey-Izquierdo, A., additional, Arikan-Akdagli, S., additional, Azoulay, E., additional, Blot, S., additional, Cortegiani, A., additional, Cornely, O.A., additional, Grecchi, C., additional, Lass-Flörl, C., additional, Koehler, P., additional, Cuenca-Estrella, M., additional, de Lange, D.W., additional, De Rosa, F.G., additional, De Waele, J.J., additional, Dimopoulos, G., additional, Garnacho-Montero, J., additional, Hoenigl, M., additional, Kanj, S.S., additional, Lamoth, F., additional, Maertens, J., additional, Martin-Loeches, I., additional, Muñoz, P., additional, Kullberg, B.J., additional, Agvald-Ohman, C., additional, Poulakou, G., additional, Rebuffi, C., additional, Rello, J., additional, Sanguinetti, M., additional, Taccone, F.S., additional, Timsit, J-F., additional, Torres, A., additional, Vazquez, J.A., additional, Wauters, J., additional, Calandra, T., additional, Tejada, S., additional, Karaiskos, I., additional, Peghin, M., additional, Vena, A., additional, Mortensen, K.L., additional, Lebihan, C., additional, and Mercier, T., additional
Published: 2022
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12. Performance of existing definitions and tests for the diagnosis of invasive aspergillosis in critically ill, non-neutropenic, adult patients: An update including COVID-19 data

Author: Akova, M., Alastruey-Izquierdo, A., Arikan-Akdagli, S., Azoulay, E., Blot, S., Cortegiani, A., Cornely, O.A., Grecchi, C., Lass-Flörl, C., Koehler, P., Cuenca-Estrella, M., de Lange, D.W., De Rosa, F.G., De Waele, J.J., Dimopoulos, G., Garnacho-Montero, J., Hoenigl, M., Kanj, S.S., Lamoth, F., Maertens, J., Martin-Loeches, I., Muñoz, P., Kullberg, B.J., Agvald-Ohman, C., Poulakou, G., Rebuffi, C., Rello, J., Sanguinetti, M., Taccone, F.S., Timsit, J-F., Torres, A., Vazquez, J.A., Wauters, J., Calandra, T., Tejada, S., Karaiskos, I., Peghin, M., Vena, A., Mortensen, K.L., Lebihan, C., Mercier, T., Bassetti, Matteo, Zuccaro, Valentina, Asperges, Erika, Scudeller, Luigia, and Giacobbe, Daniele Roberto
Published: 2022
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13. Increased mortality in systemic inflammatory response syndrome patients with high levels of coagulation factor VIIa

Author: Hyseni, A., Kemperman, H., de Lange, D.W., de Groot, P.G., Linssen, M., Kesecioglu, J., Lisman, T., and Roest, M.
Published: 2013
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14. Alarming increase in poisonings from recreational nitrous oxide use after a change in EU-legislation, inquiries to the Dutch Poisons Information Center

Author: van Riel, A.J.H.P., Hunault, C.C., van den Hengel-Koot, I.S., Nugteren-van Lonkhuyzen, J.J., de Lange, D.W., and Hondebrink, L.
Published: 2022
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15. Candidemic complications in patients with intravascular catheters colonized with Candida species: an indication for preemptive antifungal therapy?

Author: Leenders, N.H.J., Oosterheert, J.J., Ekkelenkamp, M.B., De Lange, D.W., Hoepelman, A.I.M., and Peters, E.J.G.
Published: 2011
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16. Comparison of outcome and characteristics between 6343 COVID-19 patients and 2256 other community-acquired viral pneumonia patients admitted to Dutch ICUs

Author: Brinkman, S., primary, Termorshuizen, F., additional, Dongelmans, D.A., additional, Bakhshi-Raiez, F., additional, Arbous, M.S., additional, de Lange, D.W., additional, de Keizer, N.F., additional, Verbiest, D.P., additional, te Velde, L.F., additional, van Driel, E.M., additional, Rijpstra, T., additional, Elbers, P.W.G., additional, Houwink, A.P.I., additional, Georgieva, L., additional, Verweij, E., additional, de Jong, R.M., additional, van Iersel, F.M., additional, Koning, T.J.J., additional, Rengers, E., additional, Kusadasi, N., additional, Erkamp, M.L., additional, van den Berg, R., additional, Jacobs, C.J.M.G., additional, Epker, J.L., additional, Rijkeboer, A.A., additional, de Bruin, M.T., additional, Spronk, P., additional, Draisma, A., additional, Versluis, D.J., additional, van den Berg, A.E., additional, Mos, M. Vrolijk-de, additional, Lens, J.A., additional, Pruijsten, R.V., additional, Kieft, H., additional, Rozendaal, J., additional, Nooteboom, F., additional, Boer, D.P., additional, Janssen, I.T.A., additional, van Gulik, L., additional, Koetsier, M.P., additional, Silderhuis, V.M., additional, Schnabel, R.M., additional, Drogt, I., additional, de Ruijter, W., additional, Bosman, R.J., additional, Frenzel, T., additional, Urlings-Strop, L.C., additional, Dijkhuizen, A., additional, Hené, I.Z., additional, de Meijer, A.R., additional, Holtkamp, J.W.M., additional, Postma, N., additional, Bindels, A.J.G.H., additional, Wesselink, R.M.J., additional, van Slobbe-Bijlsma, E.R., additional, van der Voort, P.H.J., additional, Eikemans, B.J.W., additional, Mehagnoul-Schipper, D.J., additional, Gommers, D., additional, Lutisan, J.G., additional, Hoeksema, M., additional, Barnas, M.G.W., additional, Festen-Spanjer, B., additional, van Lieshout, M., additional, Gritters, N.C., additional, van Tellingen, M., additional, Brunnekreef, G.B., additional, Vandeputte, J., additional, Dormans, T.P.J., additional, Hoogendoorn, M.E., additional, de Graaff, M., additional, Moolenaar, D., additional, Reidinga, A.C., additional, Spijkstra, J.J., additional, and de Waal, R., additional
Published: 2022
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17. Prognostication using SpO2/FiO2 in invasively ventilated ICU patients with ARDS due to COVID-19 – Insights from the PRoVENT-COVID study

Author: Roozeman, Jan-Paul, primary, Mazzinari, Guido, additional, Serpa Neto, Ary, additional, Hollmann, Markus W., additional, Paulus, Frederique, additional, Schultz, Marcus J., additional, Pisani, Luigi, additional, Algera, A.G., additional, Boers, L.S., additional, Bos, L.D.J., additional, Botta, M., additional, Dongelmans, D.A., additional, Hollmann, M.W., additional, Horn, J., additional, Paulus, F., additional, Pillay, J., additional, Schultz, M.J., additional, Neto, A. Serpa, additional, Tsonas, A.M., additional, Vlaar, A.P.J., additional, Ahuja, S., additional, van Akkeren, J.P., additional, Algoe, C.K., additional, van Amstel, R.B., additional, Artigas, A., additional, Baur, O.L., additional, van de Berg, P., additional, van den Berg, A.E., additional, Bergmans, D.C.J.J., additional, van den Bersselaar, D.I., additional, Bertens, F.A., additional, Bindels, A.J.G.H., additional, de Boer, M.M., additional, den Boer, S., additional, Bogerd, M., additional, Breel, J.S., additional, de Bruin, H., additional, de Bruin, S., additional, Bruna, C.L., additional, Buiteman-Kruizinga, L.A., additional, Cremer, O.L., additional, Determann, R.M., additional, Dieperink, W., additional, Franke, H.S., additional, Galek-Aldridge, M.S., additional, de Graaff, M.J., additional, Hagens, L.A., additional, Haringman, J.J., additional, van der Heide, S.T., additional, van der Heiden, P.L.J., additional, Heijnen, N.F.L., additional, Hiel, S.J.P., additional, Hoeijmakers, L.L., additional, Hol, L., additional, Hoogendoorn, M.E., additional, van der Horst, R., additional, Ie, E.L.K., additional, Ivanov, D., additional, Juffermans, N.P., additional, Kho, E., additional, de Klerk, E.S., additional, Gemert, A.W.M.M. Koopman-van, additional, Koopmans, M., additional, Kucukcelebi, S., additional, Kuiper, M.A., additional, de Lange, D.W., additional, van Mourik, N., additional, Nijbroek, S.G., additional, Onrust, M., additional, Oostdijk, E.A.N., additional, Pennartz, C.J., additional, Pisani, L., additional, Purmer, I.M., additional, Rettig, T.C.D., additional, Roozeman, J.P., additional, Schuijt, M.T.U., additional, Sleeswijk, M.E., additional, Smit, M.R., additional, Spronk, P.E., additional, Stilma, W., additional, Strang, A.C., additional, Tuinman, P.R., additional, Valk, C.M.A., additional, Veen-Schra, F.L., additional, Veldhuis, L.I., additional, van Velzen, P., additional, van der Ven, W.H., additional, van Vliet, P., additional, van der Voort, P.H.J., additional, van Welie, L., additional, Wesselink, H.J.F.T., additional, van der Wier-Lubbers, H.H., additional, van Wijk, B., additional, Winters, T., additional, Wong, W.Y., additional, and van Zanten, A.R.H., additional
Published: 2022
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18. Longitudinal respiratory subphenotypes in patients with COVID-19-related acute respiratory distress syndrome: results from three observational cohorts

Author: Bos, Lieuwe D J, primary, Sjoding, Michael, additional, Sinha, Pratik, additional, Bhavani, Sivasubramanium V, additional, Lyons, Patrick G, additional, Bewley, Alice F, additional, Botta, Michela, additional, Tsonas, Anissa M, additional, Serpa Neto, Ary, additional, Schultz, Marcus J, additional, Dickson, Robert P, additional, Paulus, Frederique, additional, van Akkeren, J.P., additional, Algera, A.G., additional, Algoe, C.K., additional, van Amstel, R.B., additional, Artigas, A., additional, Baur, O.L., additional, van de Berg, P., additional, van den Berg, A.E., additional, Bergmans, D.C.J.J., additional, van den Bersselaar, D.I., additional, Bertens, F.A., additional, Bindels, A.J.G.H., additional, de Boer, M.M., additional, den Boer, S., additional, Boers, L.S., additional, Bogerd, M., additional, Bos, L.D.J., additional, Botta, M., additional, Breel, J.S., additional, de Bruin, H., additional, de Bruin, S., additional, Bruna, C.L., additional, Buiteman-Kruizinga, L.A., additional, Cremer, O., additional, Determann, R.M., additional, Dieperink, W., additional, Dongelmans, D.A., additional, Franke, H.S., additional, Galek-Aldridge, M.S., additional, de Graaff, M.J., additional, Hagens, L.A., additional, Haringman, J.J., additional, van der Heide, S.T., additional, van der Heiden, P.L.J., additional, Heijnen, N.F.L., additional, Hiel, S.J.P., additional, Hoeijmakers, L.L., additional, Hol, L., additional, Hollmann, M.W., additional, Hoogendoorn, M.E., additional, Horn, J., additional, van der Horst, R., additional, Ie, E.L.K., additional, Ivanov, D., additional, Juffermans, N.P., additional, Kho, E., additional, de Klerk, E.S., additional, Koopman-van Gemert, A.W.M.M., additional, Koopmans, M., additional, Kucukcelebi, S., additional, Kuiper, M.A., additional, de Lange, D.W., additional, Martin-Loeches, I., additional, Mazzinari, G., additional, van Meenen, D.M.P., additional, Morales-Quinteros, L., additional, van Mourik, N., additional, Nijbroek, S.G., additional, Onrust, M., additional, Oostdijk, E.A.N., additional, Paulus, F., additional, Pennartz, C.J., additional, Pillay, J., additional, Pisani, L., additional, Purmer, I.M., additional, Rettig, T.C.D., additional, Roozeman, J.P., additional, Schuijt, M.T.U., additional, Schultz, M.J., additional, Serpa Neto, A., additional, Sleeswijk, M.E., additional, Smit, M.R., additional, Spronk, P.E., additional, Stilma, W., additional, Strang, A.C., additional, Tsonas, A.M., additional, Tuinman, P.R., additional, Valk, C.M.A., additional, Veen-Schra, F.L., additional, Veldhuis, L.I., additional, van Velzen, P., additional, van der Ven, W.H., additional, Vlaar, A.P.J., additional, van Vliet, P., additional, van der Voort, P.H.J., additional, van Welie, L., additional, Wesselink, H.J.F.T., additional, van der Wier-Lubbers, H.H., additional, van Wijk, B., additional, Winters, T., additional, Wong, W.Y., additional, and van Zanten, A.R.H., additional
Published: 2021
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19. Mortality associated with early changes in ARDS severity in COVID–19 patients – Insights from the PRoVENT–COVID study

Author: Schuijt, Michiel T.U., primary, Martin-Loeches, Ignacio, additional, Schultz, Marcus J., additional, Paulus, Frederique, additional, Neto, Ary Serpa, additional, van Akkeren, J.P., additional, Algera, A.G., additional, Algoe, C.K., additional, van Amstel, R.B., additional, Baur, O.L., additional, van de Berg, P., additional, van den Berg, A.E., additional, Bergmans, D.C.J.J., additional, van den Bersselaar, D.I., additional, Bertens, F.A., additional, Bindels, A.J.G.H., additional, de Boer, M.M., additional, den Boer, S., additional, Boers, L.S., additional, Bogerd, M., additional, Bos, L.D.J., additional, Botta, M., additional, Breel, J.S., additional, de Bruin, H., additional, de Bruin, S., additional, Bruna, C.L., additional, Buiteman-Kruizinga, L.A., additional, Cremer, O., additional, Determann, R.M., additional, Dieperink, W., additional, Dongelmans, D.A., additional, Franke, H.S., additional, Aldridge, M.S. Galek, additional, de Graaff, M.J., additional, Hagens, L.A., additional, Haringman, J.J., additional, Heijnen, N.F.L., additional, Hiel, S., additional, van der Heide, S.T., additional, van der Heiden, P.L.J., additional, Hoeijmakers, L.L., additional, Hol, L., additional, Hollmann, M.W., additional, Hoogendoorn, M.E., additional, Horn, J., additional, van der Horst, R., additional, Ie, E.L.K., additional, Ivanov, D., additional, Juffermans, N.P., additional, Kho, E., additional, de Klerk, E.S., additional, Koopman, A.W.M., additional, Koopmans, M., additional, Kucukcelebi, S., additional, Kuiper, M.A., additional, de Lange, D.W., additional, van Mourik, N., additional, Martin-Loeches, I., additional, Nijbroek, S.G., additional, Onrust, M., additional, Oostdijk, E.A.N., additional, Paulus, F., additional, Pennartz, C.J., additional, Pillay, J., additional, Pisani, L., additional, Purmer, I.M., additional, Rettig, T.C.D., additional, Roozeman, J.P., additional, Schuijt, M.T.U., additional, Schultz, M.J., additional, Neto, A. Serpa, additional, Sleeswijk, M.E., additional, Smit, M.R., additional, Spronk, P.E., additional, Stilma, W., additional, Strang, A.C., additional, Tsonas, A.M., additional, Tuinman, P.R., additional, Valk, C.M.A., additional, Veen, F.L., additional, Vlaar, A.P.J., additional, Veldhuis, L.I., additional, van Velzen, P., additional, van der Ven, W.H., additional, van Vliet, P., additional, van der Voort, P., additional, van der Wier, H.H., additional, van Welie, L., additional, Wesselink, H.J.F.T., additional, van Wijk, B., additional, Winters, T., additional, Wong, W.Y., additional, and van Zanten, A.R.H., additional
Published: 2021
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20. Predicting blood lead levels among children 2 years old, following the fire at Notre-Dame de Paris cathedral

Author: Hunault, C.C., primary, van Eijkeren, J.C., additional, de Lange, D.W., additional, and de Vries, I., additional
Published: 2021
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21. Clinically relevant potential drug-drug interactions in intensive care patients: A large retrospective observational multicenter study

Author: Bakker, T. (Tinka), Abu-Hanna, A. (Ameen), Dongelmans, D.A. (Dave), Vermeijden, W.J. (Wytze J.), Bosman, R.J. (Rob J.), de Lange, D.W. (Dylan W.), Klopotowska, J.E. (Joanna), Keizer, N.F. (Nicolette) de, Hendriks, S. (S.), ten Cate, J. (J.), Schutte, P.F. (P. F.), van Balen, D. (D.), Duyvendak, M. (M.), Karakus, A. (A.), Sigtermans, M. (M.), Kuck, E.M., Hunfeld, N.G.M. (Nicole), Sijs, I.H. (Heleen) van der, de Feiter, P.W. (P. W.), Wils, E.-J. (Evert-Jan), Spronk, P.E. (Peter), Van Kan, H.J.M., van der Steen, M.S. (M. S.), Purmer, I.M. (Ilse M.), Bosma, B.E. (Liesbeth), Kieft, H. (H.), Marum, R.J. (Rob ) van, Jonge, E. (Evert) de, Beishuizen, A. (A.), Movig, K. (K.), Mulder, F. (F.), Franssen, E.J.F., Van Den Bergh, H. (Huub), Bult, W. (W.), Hoeksema, M. (M.), Wesselink, E. (E.), Bakker, T. (Tinka), Abu-Hanna, A. (Ameen), Dongelmans, D.A. (Dave), Vermeijden, W.J. (Wytze J.), Bosman, R.J. (Rob J.), de Lange, D.W. (Dylan W.), Klopotowska, J.E. (Joanna), Keizer, N.F. (Nicolette) de, Hendriks, S. (S.), ten Cate, J. (J.), Schutte, P.F. (P. F.), van Balen, D. (D.), Duyvendak, M. (M.), Karakus, A. (A.), Sigtermans, M. (M.), Kuck, E.M., Hunfeld, N.G.M. (Nicole), Sijs, I.H. (Heleen) van der, de Feiter, P.W. (P. W.), Wils, E.-J. (Evert-Jan), Spronk, P.E. (Peter), Van Kan, H.J.M., van der Steen, M.S. (M. S.), Purmer, I.M. (Ilse M.), Bosma, B.E. (Liesbeth), Kieft, H. (H.), Marum, R.J. (Rob ) van, Jonge, E. (Evert) de, Beishuizen, A. (A.), Movig, K. (K.), Mulder, F. (F.), Franssen, E.J.F., Van Den Bergh, H. (Huub), Bult, W. (W.), Hoeksema, M. (M.), and Wesselink, E. (E.)
Abstract: Purpose: Potential drug-drug interactions (pDDIs) may harm patients admitted to the Intensive Care Unit (ICU). Due to the patient's critical condition and continuous monitoring on the ICU, not all pDDIs are clinically relevant. Clinical decision support systems (CDSSs) warning for irrelevant pDDIs could result in alert fatigue and overlooking important signals. Therefore, our aim was to describe the frequency of clinically relevant pDDIs (crpDDIs) to enable tailoring of CDSSs to the ICU setting. Materials & methods: In this multicenter retrospective observational study, we used medication administration data to identify pDDIs in ICU admissions from 13 ICUs. Clinical relevance was based on a Delphi study in which intensivists and hospital pharmacists assessed the clinical relevance of pDDIs for the ICU setting. Results: The mean number of pDDIs per 1000 medication administrations was 70.1, dropping to 31.0 when considering only crpDDIs. Of 103,871 ICU patients, 38% was exposed to a crpDDI. The most frequently occurring crpDDIs involve QT-prolonging agents, digoxin, or NSAIDs. Conclusions: Considering clinical relevance of pDDIs in the ICU setting is important, as only half of the detected pDDIs were crpDDIs. Therefore, tailoring CDSSs to the ICU may reduce alert fatigue and improve medication safety in ICU patients.
Published: 2021
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22. Duration of antibiotic treatment using procalcitonin-guided treatment algorithms in older patients: A patient-level meta-analysis from randomized controlled trials.

Author: Heilmann E., Gregoriano C., Annane D., Reinhart K., Bouadma L., Wolff M., Chastre J., Luyt C.-E., Tubach F., Branche A.R., Briel M., Christ-Crain M., Welte T., Corti C., De Jong E., Nijsten M., De Lange D.W., Van Oers J.A.H., Beishuizen A., Girbes A.R.J., Deliberato R.O., Schroeder S., Kristoffersen K.B., Layios N., Damas P., Lima S.S.S., Nobre V., Wei L., Oliveira C.F., Shehabi Y., Stolz D., Tamm M., Verduri A., Wang J.-X., Drevet S., Gavazzi G., Mueller B., Schuetz P., Heilmann E., Gregoriano C., Annane D., Reinhart K., Bouadma L., Wolff M., Chastre J., Luyt C.-E., Tubach F., Branche A.R., Briel M., Christ-Crain M., Welte T., Corti C., De Jong E., Nijsten M., De Lange D.W., Van Oers J.A.H., Beishuizen A., Girbes A.R.J., Deliberato R.O., Schroeder S., Kristoffersen K.B., Layios N., Damas P., Lima S.S.S., Nobre V., Wei L., Oliveira C.F., Shehabi Y., Stolz D., Tamm M., Verduri A., Wang J.-X., Drevet S., Gavazzi G., Mueller B., and Schuetz P.
Abstract: Background: Older patients have a less pronounced immune response to infection, which may also influence infection biomarkers. There is currently insufficient data regarding clinical effects of procalcitonin (PCT) to guide antibiotic treatment in older patients. Objective and design: We performed an individual patient data meta-analysis to investigate the association of age on effects of PCT-guided antibiotic stewardship regarding antibiotic use and outcome. Subjects and methods: We had access to 9,421 individual infection patients from 28 randomized controlled trials comparing PCT-guided antibiotic therapy (intervention group) or standard care. We stratified patients according to age in four groups (<75 years [n = 7,079], 75-80 years [n = 1,034], 81-85 years [n = 803] and >85 years [n = 505]). The primary endpoint was the duration of antibiotic treatment and the secondary endpoints were 30-day mortality and length of stay. Result(s): Compared to control patients, mean duration of antibiotic therapy in PCT-guided patients was significantly reduced by 24, 22, 26 and 24% in the four age groups corresponding to adjusted differences in antibiotic days of-1.99 (95% confidence interval [CI]-2.36 to-1.62),-1.98 (95% CI-2.94 to-1.02),-2.20 (95% CI-3.15 to-1.25) and-2.10 (95% CI-3.29 to-0.91) with no differences among age groups. There was no increase in the risk for mortality in any of the age groups. Effects were similar in subgroups by infection type, blood culture result and clinical setting (P interaction >0.05). Conclusion(s): This large individual patient data meta-analysis confirms that, similar to younger patients, PCT-guided antibiotic treatment in older patients is associated with significantly reduced antibiotic exposures and no increase in mortality. Copyright © 2021 The Author(s). Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved.
Published: 2021

23. Performance of existing definitions and tests for the diagnosis of invasive aspergillosis in critically ill, adult patients: A systematic review with qualitative evidence synthesis

Author: Bassetti, M., primary, Giacobbe, D.R., additional, Grecchi, C., additional, Rebuffi, C., additional, Zuccaro, V., additional, Scudeller, L., additional, Akova, M., additional, Alastruey-Izquierdo, A., additional, Arikan-Akdagli, S., additional, Azoulay, E., additional, Blot, S., additional, Cornely, O.A., additional, Lass-Flörl, C., additional, Koehler, P., additional, Cuenca-Estrella, M., additional, de Lange, D.W., additional, De Rosa, F.G., additional, De Waele, J.J., additional, Dimopoulos, G., additional, Garnacho-Montero, J., additional, Hoenigl, M., additional, Kanj, S.S., additional, Lamoth, F., additional, Maertens, J., additional, Martin-Loeches, I., additional, Muñoz, P., additional, Kullberg, B.J., additional, Agvald-Ohman, C., additional, Poulakou, G., additional, Rello, J., additional, Righi, E., additional, Sanguinetti, M., additional, Taccone, F.S., additional, Timsit, J-F., additional, Torres, A., additional, Vazquez, J.A., additional, Wauters, J., additional, Calandra, T., additional, Asperges, E., additional, Tejada, S., additional, Lebihan, C., additional, Karaiskos, I., additional, Peghin, M., additional, Mortensen, K.L., additional, Vena, A., additional, Cortegiani, A., additional, and Mercier, T., additional
Published: 2020
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24. Improving medication safety in the Intensive Care by identifying relevant drug-drug interactions - Results of a multicenter Delphi study

Author: Bakker, T. (Tinka), Klopotowska, J.E. (Joanna), Keizer, N.F. (Nicolette) de, Marum, R.J. (Rob ) van, Sijs, I.H. (Heleen) van der, de Lange, D.W. (Dylan W.), Jonge, E. (Evert) de, Abu-Hanna, A. (Ameen), Dongelmans, D.A. (Dave), Bakker, T. (Tinka), Klopotowska, J.E. (Joanna), Keizer, N.F. (Nicolette) de, Marum, R.J. (Rob ) van, Sijs, I.H. (Heleen) van der, de Lange, D.W. (Dylan W.), Jonge, E. (Evert) de, Abu-Hanna, A. (Ameen), and Dongelmans, D.A. (Dave)
Abstract: Purpose: Drug-drug interactions (DDIs) may cause adverse outcomes in patients admitted to the Intensive Care Unit (ICU). Computerized decision support systems (CDSSs) may help prevent DDIs by timely showing relevant warning alerts, but knowledge on which DDIs are clinically relevant in the ICU setting is limited. Therefore, the purpose of this study was to identify DDIs relevant for the ICU. Materials and methods: We conducted a modified Delphi procedure with a Dutch multidisciplinary expert panel consisting of intensivists and hospital pharmacists to assess the clinical relevance of DDIs for the ICU. The procedure consisted of two rounds, each included a questionnaire followed by a live consensus meeting. Results: In total the clinical relevance of 148 DDIs was assessed, of which agreement regarding the relevance was reached for 139 DDIs (94%). Of these 139 DDIs, 53 (38%) were considered not clinically relevant for the ICU setting. Conclusions: A list of clinically relevant DDIs for the ICU setting was established on a national level. The clinical value of CDSSs for medication safety could be improved by focusing on the identified clinically relevant DDIs, thereby avoiding alert fatigue.
Published: 2020
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25. Red wine and red wine polyphenolic compounds but not alcohol inhibit ADP-induced platelet aggregation

Author: de Lange, D.W., Van Golden, P.H., Scholman, W.L.G., Kraaijenhagen, R.J., Akkerman, J.W.N., and Van de Wiel, A.
Published: 2003
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26. Prognostication using SpO2/FiO2in invasively ventilated ICU patients with ARDS due to COVID-19 – Insights from the PRoVENT-COVID study

Author: Roozeman, Jan-Paul, Mazzinari, Guido, Serpa Neto, Ary, Hollmann, Markus W., Paulus, Frederique, Schultz, Marcus J., Pisani, Luigi, Algera, A.G., Boers, L.S., Bos, L.D.J., Botta, M., Dongelmans, D.A., Hollmann, M.W., Horn, J., Paulus, F., Pillay, J., Schultz, M.J., Neto, A. Serpa, Tsonas, A.M., Vlaar, A.P.J., Botta, M., Tsonas, A.M., Ahuja, S., van Akkeren, J.P., Algera, A.G., Algoe, C.K., van Amstel, R.B., Artigas, A., Baur, O.L., van de Berg, P., van den Berg, A.E., Bergmans, D.C.J.J., van den Bersselaar, D.I., Bertens, F.A., Bindels, A.J.G.H., de Boer, M.M., den Boer, S., Boers, L.S., Bogerd, M., Bos, L.D.J., Botta, M., Breel, J.S., de Bruin, H., de Bruin, S., Bruna, C.L., Buiteman-Kruizinga, L.A., Cremer, O.L., Determann, R.M., Dieperink, W., Dongelmans, D.A., Franke, H.S., Galek-Aldridge, M.S., de Graaff, M.J., Hagens, L.A., Haringman, J.J., van der Heide, S.T., van der Heiden, P.L.J., Heijnen, N.F.L., Hiel, S.J.P., Hoeijmakers, L.L., Hol, L., Hollmann, M.W., Hoogendoorn, M.E., Horn, J., van der Horst, R., Ie, E.L.K., Ivanov, D., Juffermans, N.P., Kho, E., de Klerk, E.S., Gemert, A.W.M.M. Koopman-van, Koopmans, M., Kucukcelebi, S., Kuiper, M.A., de Lange, D.W., van Mourik, N., Nijbroek, S.G., Onrust, M., Oostdijk, E.A.N., Paulus, F., Pennartz, C.J., Pillay, J., Pisani, L., Purmer, I.M., Rettig, T.C.D., Roozeman, J.P., Schuijt, M.T.U., Schultz, M.J., Neto, A. Serpa, Sleeswijk, M.E., Smit, M.R., Spronk, P.E., Stilma, W., Strang, A.C., Tsonas, A.M., Tuinman, P.R., Valk, C.M.A., Veen-Schra, F.L., Veldhuis, L.I., van Velzen, P., van der Ven, W.H., Vlaar, A.P.J., van Vliet, P., van der Voort, P.H.J., van Welie, L., Wesselink, H.J.F.T., van der Wier-Lubbers, H.H., van Wijk, B., Winters, T., Wong, W.Y., and van Zanten, A.R.H.
Abstract: The SpO2/FiO2is a useful oxygenation parameter with prognostic capacity in patients with ARDS. We investigated the prognostic capacity of SpO2/FiO2for mortality in patients with ARDS due to COVID–19.
Published: 2022
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27. The effect of ICU-tailored drug-drug interaction alerts on medication prescribing and monitoring: Protocol for a cluster randomized stepped-wedge trial

Author: Bakker, T. (T.), Klopotowska, J.E. (Joanna), Eslami, S. (S.), De Lange, D.W. (D. W.), Marum, R.J. (Rob ) van, Sijs, I.H. (Heleen) van der, Jonge, E. (Evert) de, Dongelmans, D.A. (Dave), Keizer, N.F. (Nicolette) de, Abu-Hanna, A. (Ameen), Bakker, T. (T.), Klopotowska, J.E. (Joanna), Eslami, S. (S.), De Lange, D.W. (D. W.), Marum, R.J. (Rob ) van, Sijs, I.H. (Heleen) van der, Jonge, E. (Evert) de, Dongelmans, D.A. (Dave), Keizer, N.F. (Nicolette) de, and Abu-Hanna, A. (Ameen)
Abstract: Background: Drug-drug interactions (DDIs) can cause patient harm. Between 46 and 90% of patients admitted to the Intensive Care Unit (ICU) are exposed to potential DDIs (pDDIs). This rate is twice as high as patients on general wards. Clinical decision support systems (CDSSs) have shown their potential to prevent pDDIs. However, the literature shows that there is considerable room for improvement of CDSSs, in particular by increasing the clinical relevance of the pDDI alerts they generate and thereby reducing alert fatigue. However, consensus on which pDDIs are clinically relevant in the ICU setting is lacking. The primary aim of this study is to evaluate the effect of alerts based on only clinically relevant interactions for the ICU setting on the prevention of pDDIs among Dutch ICUs. Methods: To define the clinically relevant pDDIs, we will follow a rigorous two-step Delphi procedure in which a national expert panel will assess which pDDIs are perceived clinically relevant for the Dutch ICU setting. The intervention is the CDSS that generates alerts based on the clinically relevant pDDIs. The intervention will be evaluated in a stepped-wedge trial. A total of 12 Dutch adult ICUs using the same patient data management system, in which the CDSS will operate, were invited to participate in the trial. Of the 12 ICUs, 9 agreed to participate and will be enrolled in the trial. Our primary outcome measure is the incidence of clinically relevant pDDIs per 1000 medication administrations. Discussion: This study will identify pDDIs relevant for the ICU setting. It will also enhance our understanding of the effectiveness of alerts confined to clinically relevant pDDIs. Both of these contributions can facilitate the successful implementation of CDSSs in the ICU and in other domains as well. Trial registration: Nederlands Trial register Identifier: NL6762. Registered November 26, 2018.
Published: 2019
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28. Developing definitions for invasive fungal diseases in critically ill adult patients in intensive care units. Protocol of the FUNgal infections Definitions in ICU patients (FUNDICU) project

Author: Bassetti, M. Scudeller, L. Giacobbe, D.R. Lamoth, F. Righi, E. Zuccaro, V. Grecchi, C. Rebuffi, C. Akova, M. Alastruey-Izquierdo, A. Arikan-Akdagli, S. Azoulay, E. Blot, S.I. Cornely, O.A. Lass-Flörl, C. Koehler, P. Cuenca-Estrella, M. de Lange, D.W. De Rosa, F.G. De Waele, J.J. Dimopoulos, G. Garnacho-Montero, J. Hoenigl, M. Kanj, S.S. Maertens, J. Martin-Loeches, I. Muñoz, P. Kullberg, B.J. Agvald-Ohman, C. Poulakou, G. Rello, J. Sanguinetti, M. Taccone, F.S. Timsit, J.-F. Torres, A. Vazquez, J.A. Calandra, T. from the Study Group for Infections in Critically Ill Patients (ESGCIP) the Fungal Infection Study Group (EFISG) of the European Society of Clinical Microbiology Infectious Diseases (ESCMID) the European Society of Intensive Care Medicine (ESICM) the European Confederation of Medical Mycology (ECMM) the Mycoses Study Group Education Research Consortium (MSGERC)
Abstract: Background: The reliability of diagnostic criteria for invasive fungal diseases (IFD) developed for severely immunocompromised patients is questionable in critically ill adult patients in intensive care units (ICU). Objectives: To develop a standard set of definitions for IFD in critically ill adult patients in ICU. Methods: Based on a systematic literature review, a list of potential definitions to be applied to ICU patients will be developed by the ESCMID Study Group for Infections in Critically Ill Patients (ESGCIP) and the ESCMID Fungal Infection Study Group (EFISG) chairpersons. The proposed definitions will be evaluated by a panel of 30 experts using the RAND/UCLA appropriateness methods. The panel will rank each of the proposed definitions on a 1-9 scale trough a dedicated questionnaire, in two rounds: one remote and one face-to-face. Based on their median rank and the level of agreement across panel members, selected definitions will be organised in a main consensus document and in an executive summary. The executive summary will be made available online for public comments. Conclusions: The present consensus project will seek to provide standard definitions for IFD in critically ill adult patients in ICU, with the ultimate aims of improving their clinical outcome and facilitating the comparison and generalizability of research findings. © 2018 Blackwell Verlag GmbH
Published: 2018

29. Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections.

Author: Welte T., Sager R., Christ-Crain M., Stolz D., Tamm M., Bouadma L., Luyt C.E., Wolff M., Chastre J., Tubach F., Kristoffersen K.B., Burkhardt O., Wirz Y., Schroeder S., Nobre V., Wei L., Bucher H.C., Bhatnagar N., Annane D., Reinhart K., Branche A., Damas P., Nijsten M., de Lange D.W., Deliberato R.O., Lima S.S., Maravic-Stojkovic V., Verduri A., Cao B., Shehabi Y., Beishuizen A., Jensen J.-U.S., Corti C., Van Oers J.A., Falsey A.R., de Jong E., Oliveira C.F., Beghe B., Briel M., Mueller B., Schuetz P., Welte T., Sager R., Christ-Crain M., Stolz D., Tamm M., Bouadma L., Luyt C.E., Wolff M., Chastre J., Tubach F., Kristoffersen K.B., Burkhardt O., Wirz Y., Schroeder S., Nobre V., Wei L., Bucher H.C., Bhatnagar N., Annane D., Reinhart K., Branche A., Damas P., Nijsten M., de Lange D.W., Deliberato R.O., Lima S.S., Maravic-Stojkovic V., Verduri A., Cao B., Shehabi Y., Beishuizen A., Jensen J.-U.S., Corti C., Van Oers J.A., Falsey A.R., de Jong E., Oliveira C.F., Beghe B., Briel M., Mueller B., and Schuetz P.
Abstract: Background: Acute respiratory infections (ARIs) comprise of a large and heterogeneous group of infections including bacterial, viral, and other aetiologies. In recent years, procalcitonin (PCT), a blood marker for bacterial infections, has emerged as a promising tool to improve decisions about antibiotic therapy (PCT-guided antibiotic therapy). Several randomised controlled trials (RCTs) have demonstrated the feasibility of using procalcitonin for starting and stopping antibiotics in different patient populations with ARIs and different settings ranging from primary care settings to emergency departments, hospital wards, and intensive care units. However, the effect of using procalcitonin on clinical outcomes is unclear. This is an update of a Cochrane review and individual participant data meta-analysis first published in 2012 designed to look at the safety of PCT-guided antibiotic stewardship. Objective(s): The aim of this systematic review based on individual participant data was to assess the safety and efficacy of using procalcitonin for starting or stopping antibiotics over a large range of patients with varying severity of ARIs and from different clinical settings. Search Method(s): We searched the Cochrane Central Register of Controlled Trials (CENTRAL), which contains the Cochrane Acute Respiratory Infections Group's Specialised Register, MEDLINE, and Embase, in February 2017, to identify suitable trials. We also searched ClinicalTrials.gov to identify ongoing trials in April 2017. Selection Criteria: We included RCTs of adult participants with ARIs who received an antibiotic treatment either based on a procalcitonin algorithm (PCT-guided antibiotic stewardship algorithm) or usual care. We excluded trials if they focused exclusively on children or used procalcitonin for a purpose other than to guide initiation and duration of antibiotic treatment. Data Collection and Analysis: Two teams of review authors independently evaluated the methodology and extracted
Published: 2017

30. Effect of procalcitonin-guided antibiotic treatment on mortality in acute respiratory infections: a patient level meta-analysis.

Author: Kristoffersen K.B., Wirz Y., Sager R., Christ-Crain M., Stolz D., Tamm M., Bouadma L., Luyt C.E., Wolff M., Chastre J., Maravic-Stojkovic V., Verduri A., Beghe B., Cao B., Shehabi Y., Jensen J.-U.S., Corti C., van Oers J.A.H., Beishuizen A., Girbes A.R.J., de Jong E., Briel M., Mueller B., Tubach F., Schuetz P., Burkhardt O., Welte T., Schroeder S., Nobre V., Wei L., Bucher H.C., Annane D., Reinhart K., Falsey A.R., Branche A., Damas P., Nijsten M., de Lange D.W., Deliberato R.O., Oliveira C.F., Kristoffersen K.B., Wirz Y., Sager R., Christ-Crain M., Stolz D., Tamm M., Bouadma L., Luyt C.E., Wolff M., Chastre J., Maravic-Stojkovic V., Verduri A., Beghe B., Cao B., Shehabi Y., Jensen J.-U.S., Corti C., van Oers J.A.H., Beishuizen A., Girbes A.R.J., de Jong E., Briel M., Mueller B., Tubach F., Schuetz P., Burkhardt O., Welte T., Schroeder S., Nobre V., Wei L., Bucher H.C., Annane D., Reinhart K., Falsey A.R., Branche A., Damas P., Nijsten M., de Lange D.W., Deliberato R.O., and Oliveira C.F.
Abstract: Background In February, 2017, the US Food and Drug Administration approved the blood infection marker procalcitonin for guiding antibiotic therapy in patients with acute respiratory infections. This meta-analysis of patient data from 26 randomised controlled trials was designed to assess safety of procalcitonin-guided treatment in patients with acute respiratory infections from different clinical settings. Methods Based on a prespecified Cochrane protocol, we did a systematic literature search on the Cochrane Central Register of Controlled Trials, MEDLINE, and Embase, and pooled individual patient data from trials in which patients with respiratory infections were randomly assigned to receive antibiotics based on procalcitonin concentrations (procalcitonin-guided group) or control. The coprimary endpoints were 30-day mortality and setting-specific treatment failure. Secondary endpoints were antibiotic use, length of stay, and antibiotic side-effects. Findings We identified 990 records from the literature search, of which 71 articles were assessed for eligibility after exclusion of 919 records. We collected data on 6708 patients from 26 eligible trials in 12 countries. Mortality at 30 days was significantly lower in procalcitonin-guided patients than in control patients (286 [9%] deaths in 3336 procalcitonin-guided patients vs 336 [10%] in 3372 controls; adjusted odds ratio [OR] 0.83 [95% CI 0.70 to 0.99], p=0.037). This mortality benefit was similar across subgroups by setting and type of infection (pinteractions>0.05), although mortality was very low in primary care and in patients with acute bronchitis. Procalcitonin guidance was also associated with a 2.4-day reduction in antibiotic exposure (5.7 vs 8.1 days [95% CI -2.71 to -2.15], p<0.0001) and a reduction in antibiotic-related side-effects (16% vs 22%, adjusted OR 0.68 [95% CI 0.57 to 0.82], p<0.0001). Interpretation Use of procalcitonin to guide antibiotic treatment in patients with acute respiratory infectio
Published: 2017

31. Population Pharmacokinetic Model and Pharmacokinetic Target Attainment of Micafungin in Intensive Care Unit Patients

Author: Martial, L.C. (Lisa C.), Ter Heine, R. (Rob), Schouten, J. (Jeroen), Hunfeld, N.G.M. (Nicole), Van Leeuwen, H.J. (Henk J.), Verweij, P.E. (Paul), de Lange, D.W. (Dylan W.), Pickkers, P. (Peter), Brüggemann, M. (Monika), Martial, L.C. (Lisa C.), Ter Heine, R. (Rob), Schouten, J. (Jeroen), Hunfeld, N.G.M. (Nicole), Van Leeuwen, H.J. (Henk J.), Verweij, P.E. (Paul), de Lange, D.W. (Dylan W.), Pickkers, P. (Peter), and Brüggemann, M. (Monika)
Abstract: _Objective:_ To study the pharmacokinetics of micafungin in intensive care patients and assess pharmacokinetic (PK) target attainment for various dosing strategi
Published: 2017
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32. Extracorporeal membrane oxygenation in the treatment of poisoned patients

Author: de Lange, D.W., Sikma, M.A., and Meulenbelt, J.
Subjects: Circulatory shock, Poisoning, Intoxication, Journal Article, ARDS, Review, ECMO, ECLS, Toxicology
Abstract: CONTEXT : Although extracorporeal membrane oxygenation (ECMO) was used in many patients following its introduction in 1972, most hospitals had abandoned this experimental treatment for adult patients. Recently, improvements in the ECMO circuitry rendered it more biocompatible. The surprisingly low mortality in patients with severe acute respiratory distress syndrome who were treated with ECMO in the influenza A/H1N1 pandemic of 2009 resurrected interest in ECMO in many intensive care units around the world. OBJECTIVES: This article reviews the different techniques of ECMO, the indications, contraindications and complications of its use, its role in poisoned patients and the ethics of its use. METHODS: We searched Pubmed, Toxnet, Cochrane database and Embase from 1966 to September 2012 using the search terms (''extracorporeal membrane oxygenation'', 'extracorporeal life support', 'ECMO', 'ECLS', 'assist-device', and 'intox*' or 'poison*'). These searches identified 242 papers of which 116 described ECMO in conditions other than intoxications or were reviews. In total 46 publications selected for this manuscript were case reports or case series involving poisoned patients. ECMO TECHNIQUES: Two types of ECMO are used: veno-venous ECMO (VV-ECMO) or veno-arterial ECMO (VA-ECMO). VV-ECMO is used for patients with severe ARDS to secure adequate oxygenation of the organs while protecting the lungs from harmful ventilation pressures or prolonged inspiratory fraction of oxygen. VA-ECMO can be used whenever the patient remains in shock despite adequate fluid resuscitation and is refractory to administration of inotropes and vasopressors. INDICATIONS: The organ support that can be applied with ECMO makes it especially useful in patients with severe poisoning as the clinical impact of the intoxication is often temporary; ECMO can be used as a 'bridge to recovery'. CONTRAINDICATIONS: Absolute contraindications are uncontrolled coagulopathy and severe intracranial bleeding, which precludes the use of anticoagulation therapy. Relative contraindications to ECMO include advanced age, severe irreversible brain injury, untreatable metastatic cancer, severe organ dysfunction (some suggest a Sequential Organ Failure Assessment (SOFA) score > 15), and high pressure positive pressure ventilation for more than 7 days. COMPLICATIONS: The most common complication of ECMO is either bleeding at the cannulation site (in VV-ECMO) or bleeding at the surgical entry site (in VA-ECMO). Overall bleeding complications currently occur in 10-36% patients, and intracranial haemorrhage is seen in up to 6% of patients. ECMO should be reserved, therefore, for the most severely ill poisoned patients with a high risk of death. ECMO in poisoned patients. There are no randomised trials of ECMO in poisoned patients with refractory shock or who have ARDS caused by an intoxication. VV-ECMO can be considered in patients with type l and ll respiratory failure. In patients with life-threatening haemodynamic instability, VA-ECMO can be considered when shock persists despite volume administration, inotropes and vasoconstrictors, and (sometimes) intra-aortic balloon counterpulsation. Typical examples include poisoning due to calcium channel antagonists, beta-blockers, tricyclic antidepressants, chloroquine and colchicine. ETHICS OF ECMO USE: It is only ethical to use such a costly intervention (£19,252 and US$ 31,000 per quality-adjusted life year) if the treatment has a real purpose such as a 'bridge to recovery', a 'bridge to transplant', or a 'bridge to permanent assist device' (in the case of persistent cardiac failure). CONCLUSIONS: In the last decade, ECMO equipment has improved considerably, rendering it more biocompatible, and it has been used more frequently as an assist device for patients needing oxygenation as well as circulatory support. ECMO is considered a good salvage therapy for patients who are severely poisoned with ARDS or refractory circulatory shock.
Published: 2013

33. Extracorporeal membrane oxygenation in the treatment of poisoned patients

Author: Other research (not in main researchprogram), Intensive Care Centrum, Spoedeisende Hulp, NVIC, de Lange, D.W., Sikma, M.A., Meulenbelt, J., Other research (not in main researchprogram), Intensive Care Centrum, Spoedeisende Hulp, NVIC, de Lange, D.W., Sikma, M.A., and Meulenbelt, J.
Published: 2013

34. Do intensive care data on respiratory infections reflect influenza epidemics?

Author: Koetsier, A., van Asten, L., Dijkstra, F., van der Hoek, W., Snijders, B.E., van den Wijngaard, C.C., Boshuizen, H.C., Donker, G.A., de Lange, D.W., de Keizer, N.F., Koetsier, A., van Asten, L., Dijkstra, F., van der Hoek, W., Snijders, B.E., van den Wijngaard, C.C., Boshuizen, H.C., Donker, G.A., de Lange, D.W., and de Keizer, N.F.
Abstract: Objectives Severe influenza can lead to Intensive Care Unit (ICU) admission. We explored whether ICU data reflect influenza like illness (ILI) activity in the general population, and whether ICU respiratory infections can predict influenza epidemics. Methods We calculated the time lag and correlation between ILI incidence (from ILI sentinel surveillance, based on general practitioners (GP) consultations) and percentages of ICU admissions with a respiratory infection (from the Dutch National Intensive Care Registry) over the years 2003–2011. In addition, ICU data of the first three years was used to build three regression models to predict the start and end of influenza epidemics in the years thereafter, one to three weeks ahead. The predicted start and end of influenza epidemics were compared with observed start and end of such epidemics according to the incidence of ILI. Results Peaks in respiratory ICU admissions lasted longer than peaks in ILI incidence rates. Increases in ICU admissions occurred on average two days earlier compared to ILI. Predicting influenza epidemics one, two, or three weeks ahead yielded positive predictive values ranging from 0.52 to 0.78, and sensitivities from 0.34 to 0.51. Conclusions ICU data was associated with ILI activity, with increases in ICU data often occurring earlier and for a longer time period. However, in the Netherlands, predicting influenza epidemics in the general population using ICU data was imprecise, with low positive predictive values and sensitivities.
Published: 2013

35. From red wine to polyphenols and back: A journey through the history of the French Paradox

Author: de Lange, D.W., primary
Published: 2007
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36. The association of the Activities of Daily Living and the outcome of old intensive care patients suffering from COVID-19

Author: Bruno, Raphael Romano, Wernly, Bernhard, Flaatten, Hans, Fjølner, Jesper, Artigas, Antonio, Baldia, Philipp Heinrich, Binneboessel, Stephan, Bollen Pinto, Bernardo, Schefold, Joerg C., Wolff, Georg, Kelm, Malte, Beil, Michael, Sviri, Sigal, van Heerden, Peter Vernon, Szczeklik, Wojciech, Elhadi, Muhammed, Joannidis, Michael, Oeyen, Sandra, Kondili, Eumorfia, Marsh, Brian, Wollborn, Jakob, Andersen, Finn H., Moreno, Rui, Leaver, Susannah, Boumendil, Ariane, De Lange, Dylan W., Guidet, Bertrand, Jung, Christian, Eller, Philipp, Mesotten, Dieter, Reper, Pascal, Swinnen, Walter, Serck, Nicolas, Dewaele, Elisabeth, Brix, Helene, Brushoej, Jens, Kumar, Pritpal, Nedergaard, Helene Korvenius, Balleby, Ida Riise, Bundesen, Camilla, Hansen, Maria Aagaard, Uhrenholt, Stine, Bundgaard, Helle, Gooch, James, Cagova, Lenka, Potter, Elizabeth, Reay, Michael, Davey, Miriam, Abusayed, Mohammed Abdelshafy, Humphreys, Sally, Galbois, Arnaud, Charron, Cyril, Berlemont, Caroline Hauw, Besch, Guillaume, Rigaud, Jean-Philippe, Maizel, Julien, Djibré, Michel, Burtin, Philippe, Garcon, Pierre, Nseir, Saad, Valette, Xavier, Alexandru, Nica, Marin, Nathalie, Vaissiere, Marie, Plantefeve, Gaëtan, Vanderlinden, Thierry, Jurcisin, Igor, Megarbane, Buno, Chousterman, Benjamin Glenn, Dépret, François, Garnier, Marc, Besset, Sebastien, Oziel, Johanna, Ferre, Alexis, Dauger, Stéphane, Dumas, Guillaume, Goncalves, Bruno, Vettoretti, Lucie, Thevenin, Didier, Schaller, Stefan, Kurt, Muhammed, Faltlhauser, Andreas, Meyer, Christian, Milovanovic, Milena, Lutz, Matthias, Shala, Gonxhe, Haake, Hendrik, Randerath, Winfried, Kunstein, Anselm, Meybohm, Patrick, Steiner, Stephan, Barth, Eberhard, Poerner, Tudor, Simon, Philipp, Lorenz, Marco, Dindane, Zouhir, Kuhn, Karl Friedrich, Welte, Martin, Voigt, Ingo, Kabitz, Hans-Joachim, Goebel, Ulrich, Stoll, Sandra Emily, Kindgen-Milles, Detlef, Dubler, Simon, Fuest, Kristina, Schuster, Michael, Papadogoulas, Antonios, Mulita, Francesk, Rovina, Nikoletta, Aidoni, Zoi, Chrisanthopoulou, Evangelia, Andrianopoulos, Ioannis, Groenendijk, Martijn, Evers, Mirjam, van Lelyveld-Haas, Lenneke, Meynaar, Iwan, Cornet, Alexander Daniel, Zegers, Marieke, Dieperink, Willem, Dormans, Tom, Hahn, Michael, Sjøbøe, Britt, Strietzel, Hans Frank, Olasveengen, Theresa, Romundstad, Luis, Kluzik, Anna, Zatorski, Paweł, Drygalski, Tomasz, Klimkiewicz, Jakub, Solek-pastuszka, Joanna, Onichimowski, Dariusz, Czuczwar, Miroslaw, Gawda, Ryszard, Stefaniak, Jan, Stefanska-Wronka, Karina, Zabul, Ewa, Oliveira, Ana Isabel Pinho, Assis, Rui, de Lurdes Campos Santos, Maria, Santos, Henrique, Cardoso, Filipe Sousa, Gordinho, André, Banzo, Maria José Arche, Zalba-Etayo, Begoña, Cubero, Patricia Patricia, Priego, Jesús, Gomà, Gemma, Tomasa-Irriguible, Teresa Maria, Sancho, Susana, Ferreira, Aida Fernández, Vázquez, Eric Mayor, Mira, Ángela Prado, Ibarz, Mercedes, Iglesias, David, Arias-Rivera, Susana, Frutos-Vivar, Fernando, Lopez-Cuenca, Sonia, Aldecoa, Cesar, Perez-Torres, David, Canas-Perez, Isabel, Tamayo-Lomas, Luis, Diaz-Rodriguez, Cristina, de Gopegui, Pablo Ruiz, Ben-Hamouda, Nawfel, Roberti, Andrea, Fleury, Yvan, Abidi, Nour, Chau, Ivan, Dullenkopf, Alexander, Pugh, Richard, Smuts, Sara, COVIP study group, [missing], Critical care, Anesthesiology, Peri-operative and Emergency medicine (CAPE), NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM), COVIP study group, Eller, P., Joannidis, M., Mesotten, D., Reper, P., Oeyen, S., Swinnen, W., Serck, N., Dewaele, E., Brix, H., Brushoej, J., Kumar, P., Nedergaard, H.K., Balleby, I.R., Bundesen, C., Hansen, M.A., Uhrenholt, S., Bundgaard, H., Fjølner, J., Gooch, J., Cagova, L., Potter, E., Reay, M., Davey, M., Abusayed, M.A., Humphreys, S., Galbois, A., Guidet, B., Charron, C., Berlemont, C.H., Besch, G., Rigaud, J.P., Maizel, J., Djibré, M., Burtin, P., Garcon, P., Nseir, S., Valette, X., Alexandru, N., Marin, N., Vaissiere, M., Plantefeve, G., Vanderlinden, T., Jurcisin, I., Megarbane, B., Chousterman, B.G., Dépret, F., Garnier, M., Besset, S., Oziel, J., Ferre, A., Dauger, S., Dumas, G., Goncalves, B., Vettoretti, L., Thevenin, D., Schaller, S., Kurt, M., Faltlhauser, A., Meyer, C., Milovanovic, M., Lutz, M., Shala, G., Haake, H., Randerath, W., Kunstein, A., Meybohm, P., Steiner, S., Barth, E., Poerner, T., Simon, P., Lorenz, M., Dindane, Z., Kuhn, K.F., Welte, M., Voigt, I., Kabitz, H.J., Wollborn, J., Goebel, U., Stoll, S.E., Kindgen-Milles, D., Dubler, S., Jung, C., Fuest, K., Schuster, M., Papadogoulas, A., Mulita, F., Rovina, N., Aidoni, Z., Chrisanthopoulou, E., Kondili, E., Andrianopoulos, I., Groenendijk, M., Evers, M., van Lelyveld-Haas, L., Meynaar, I., Cornet, A.D., Zegers, M., Dieperink, W., De Lange, D.W., Dormans, T., Hahn, M., Sjøbøe, B., Strietzel, H.F., Olasveengen, T., Romundstad, L., Andersen, F.H., Kluzik, A., Zatorski, P., Drygalski, T., Szczeklik, W., Klimkiewicz, J., Solek-Pastuszka, J., Onichimowski, D., Czuczwar, M., Gawda, R., Stefaniak, J., Stefanska-Wronka, K., Zabul, E., Oliveira, AIP, Assis, R., de Lurdes Campos Santos, M., Santos, H., Cardoso, F.S., Gordinho, A., Banzo, MJA, Zalba-Etayo, B., Cubero, P.P., Priego, J., Gomà, G., Tomasa-Irriguible, T.M., Sancho, S., Ferreira, A.F., Vázquez, E.M., Mira, Á.P., Ibarz, M., Iglesias, D., Arias-Rivera, S., Frutos-Vivar, F., Lopez-Cuenca, S., Aldecoa, C., Perez-Torres, D., Canas-Perez, I., Tamayo-Lomas, L., Diaz-Rodriguez, C., de Gopegui, P.R., Ben-Hamouda, N., Roberti, A., Fleury, Y., Abidi, N., Schefold, J.C., Chau, I., Dullenkopf, A., Pugh, R., and Smuts, S.
Subjects: IMPACT, MORTALITY, ICU, Medicine and Health Sciences, ILL ELDERLY-PATIENTS, 610 Medicine & health, ddc:610, Critical Care and Intensive Care Medicine, 610 Medizin und Gesundheit, FRAILTY, human activities, Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18]
Abstract: Open Access funding enabled and organized by Projekt DEAL. This study was endorsed by the ESICM. Free support for running the electronic database and was granted from the dep. of Epidemiology, University of Aarhus, Denmark. Bruno et al. Annals of Intensive Care (2022) 12:26 Page 10 of 11 The support of the study in France by a grant from Fondation Assistance Publique-Hôpitaux de Paris pour la recherche is greatly appreciated. In Norway, the study was supported by a grant from the Health Region West. In addition, the study was supported by a grant from the European Open Science Cloud (EOSC). EOSCsecretariat.eu has received funding from the European Union’s Horizon Programme call H2020-INFRAEOSC-05-2018-2019, grant agreement number 831644. This work was supported by the Collaborative Research Center SFB 1116 (German Research Foundation, DFG) and by the Forschungskommission of the Medical Faculty of the Heinrich-Heine-University Düsseldorf and No. 2020–21 to RRB for a Clinician Scientist Track. No (industry) sponsorship has been received for this investigator-initiated study. PURPOSE: Critically ill old intensive care unit (ICU) patients suffering from Sars-CoV-2 disease (COVID-19) are at increased risk for adverse outcomes. This post hoc analysis investigates the association of the Activities of Daily Living (ADL) with the outcome in this vulnerable patient group. METHODS: The COVIP study is a prospective international observational study that recruited ICU patients ≥ 70 years admitted with COVID-19 (NCT04321265). Several parameters including ADL (ADL; 0 = disability, 6 = no disability), Clinical Frailty Scale (CFS), SOFA score, intensive care treatment, ICU- and 3-month survival were recorded. A mixed-effects Weibull proportional hazard regression analyses for 3-month mortality adjusted for multiple confounders. RESULTS: This pre-specified analysis included 2359 patients with a documented ADL and CFS. Most patients evidenced independence in their daily living before hospital admission (80% with ADL = 6). Patients with no frailty and no disability showed the lowest, patients with frailty (CFS ≥ 5) and disability (ADL
Published: 2022
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37. The impact of frailty on survival in elderly intensive care patients with COVID-19: the COVIP study

Author: Christian Jung, Hans Flaatten, Jesper Fjølner, Raphael Romano Bruno, Bernhard Wernly, Antonio Artigas, Bernardo Bollen Pinto, Joerg C. Schefold, Georg Wolff, Malte Kelm, Michael Beil, Sviri Sigal, Peter Vernon van Heerden, Wojciech Szczeklik, Miroslaw Czuczwar, Muhammed Elhadi, Michael Joannidis, Sandra Oeyen, Tilemachos Zafeiridis, Brian Marsh, Finn H. Andersen, Rui Moreno, Maurizio Cecconi, Susannah Leaver, Ariane Boumendil, Dylan W. De Lange, Bertrand Guidet, COVIP study group, Flaatten, H., Wernly, B., Artigas, A., Beil, M., Sviri, S., van Heerden, P.V., Szczeklik, W., Elhadi, M., Zafeiridis, T., Moreno, R., Cecconi, M., Boumendil, A., Abosheaishaa, H.M., Abualqumboz, EMY, Ahmed, A.K., Ahmed, H., Aidoni, Z., Aldecoa, C., Alexandru, N., Ali, YKNM, Al-Sadawi, M., Andersen, K., Andersen, F.H., Assis, R., Azab, M.A., Azzam, A.Y., Badawy, M.R., Balleby, I.R., Barth, E., Ben-HAmouda, N., Besch, G., Besset, S., Bjerregaard, A.T., Brix, H., Bruno, R.R., Brushoej, J., Bundgaard, H., Burtin, P., Caillard, A., Canas-Perez, I., Charron, C., Chrisanthopoulou, E., Comellini, V., Cornet, A., Cubero, P.J., Czuczwar, M., Dauger, S., Diaz-Rodriguez, C., Dieperink, W., Dindane, Z., Djibré, M., Dormans, T., Dullenkopf, A., Dumas, G., Elgazzar, Y.A., Eller, P., Elsaka, A., Evers, M., Faltlhauser, A., Ferreira, A.F., Fjølner, J., Fleury, Y., Galbois, A., Garcon, P., Garnier, M., Gawda, R., Ghannam, A., Goebel, U., Gomà, G., Goncalves, B., Gordinho, A., Groenendijk, M., Guerot, E., Guidet, B., Gurjar, M., Haake, H., Haas, L., Habib, A.A., Hahn, M., Hansen, M.A., Hilles, MMY, Hussein, AARM, Iglesias, D., Joannidis, M., Jung, C., Jurcisin, I., Kabitz, H.J., Kelm, M., Kindgen-Milles, D., Klimkiewicz, J., Kuhn, K.F., Kunstein, A., Kurt, M., De Lange, D.W., Leaver, S., Lutz, M., Mahmoodpoor, A., Maizel, J., Marin, N., Marsh, B., Megarbane, B., Mesotten, D., Meybohm, P., Meyer, C., Mira, A.P., Namendys-Silva, S.A., Nedergaard, H.K., Nseir, S., Oeyen, S., Olasveengen, T., Oliveira, AIP, Oziel, J., Papadogoulas, A., Perez-Torres, D., Bollen Pinto, B., Piton, G., Plantefeve, G., Poerner, T., Priego, J., Rabha, A., Randerath, W., Raphaelen, J.H., Reper, P., Rigaud, J.P., Rivera, S.A., Roberti, A., Romundstad, L., Rovina, N., Salah, R., Saleh, M., Sancho, S., de Lurdes Campos Santos, M., Santos, H., Schaller, S., Schefold, J.C., Schuster, M., Shala, G., Sjøbø, B., Steiner, S., Strietzel, H.F., Swinnen, W., Tamayo-Lomas, L., Tharwat, S., Tomasa, T., Uhrenholt, S., Vaissiere, M., Valent, A., Valette, X., Vanderlinden, T., Vázquez, E.M., Villamayor, M.I., Villefrance, M., Voigt, I., Wassim, K., Welte, M., Wolff, G., Wollborn, J., Zalba-Etayo, B., Zegers, M., and Critical care, Anesthesiology, Peri-operative and Emergency medicine (CAPE)
Subjects: Male, Aged, 80 and over, Pandemia, COVID-19/mortality, Frailty, Critical Care, Frail Elderly/statistics & numerical data, COVID-19, 610 Medicine & health, Prognosis, Survival Analysis, Elderly, Frailty/mortality, Humans, Female, Prospective Studies, Outcome, Aged, COVID-19/therapy
Abstract: BackgroundThe COVID-19 pandemic has led highly developed healthcare systems to the brink of collapse due to the large numbers of patients being admitted into hospitals. One of the potential prognostic indicators in patients with COVID-19 is frailty. The degree of frailty could be used to assist both the triage into intensive care, and decisions regarding treatment limitations. Our study sought to determine the interaction of frailty and age in elderly COVID-19 ICU patients.MethodsA prospective multi-centre study of COVID-19 patients ≥ 70 years admitted to intensive care in 138 ICUs from 28 countries was conducted. The primary endpoint was 30-day mortality. Frailty was assessed using the Clinical Frailty Scale (CFS). Additionally, comorbidities, management strategies and treatment limitations were recorded.ResultsThe study included 1346 patients (28% female) with a median age of 75 years (IQR 72-78, range 70-96), 16.3% were older than 80 years and 21% of the patients were frail. The overall survival at 30 days was 59% (95%CI 56-62), with 66% (63-69) in fit, 53% (47-61) in vulnerable and 41% (35-47) in frail patients (pConclusionFrailty provides relevant prognostic information in elderly COVID-19 patients in addition to age and comorbidities.
Published: 2021
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38. Cumulative Prognostic Score Predicting Mortality in Patients Older Than 80 Years Admitted to the ICU

Author: de Lange D. W., Brinkman S., Flaatten H., Boumendil A., Morandi A., Andersen F. H., Artigas A., Bertolini G., Cecconi M., Christensen S., Faraldi L., Fjolner J., Jung C., Marsh B., Moreno R., Oeyen S., Ohman C. A., Bollen Pinto B., de Smet A. M. G. A., Soliman I. W., Szczeklik W., Valentin A., Watson X., Zafeiridis T., Guidet B., Schmutz R., Wimmer F., Eller P., Joannidis M., De Buysscher P., De Neve N., Swinnen W., Abraham P., Hergafi L., Schefold Joerg. C., Biskup E., Piza P., Taliadoros I., Dey N., Solling C., Rasmussen B. S., Forceville X., Besch G., Mentec H., Michel P., Mateu P., Vettoretti L., Bourenne J., Marin N., Guillot M., Aissaoui N., Goulenok C., Thieulot-Rolin N., Messika J., Lamhaut L., Charron C., Lauten A., Sacher A. L., Brenner T., Franz M., Bloos F., Ebelt H., Schaller S. J., Fuest Kristina., Rabe C., Dieck T., Steiner S., Graf T., Nia A. M., Janosi R. A., Meybohm P., Simon P., Utzolino S., Rahmel T., Barth E., Schuster M., Aidoni Z., Aloizos S., Tasioudis P., Lampiri K., Zisopoulou V., Ravani I., Pagaki E., Antoniou A., Katsoulas T. A., Kounougeri A., Marinakis G., Tsimpoukas F., Spyropoulou A., Zygoulis P., Kyparissi A., Gupta M., Gurjar M., Maji I. M., Hayes I., Kelly Y., Westbrook A., Fitzpatrick G., Maheshwari D., Motherway C., Negri G., Spadaro S., Nattino G., Pedeferri M., Boscolo A., Rossi S., Calicchio G., Cubattoli L., Di Lascio G., Barbagallo M., Berruto F., Codazzi D., Bottazzi A., Fumagalli P., Negro G., Lupi G., Savelli F., Vulcano Giuseppe. A., Fumagalli R., Marudi A., Lefons U., Lembo R., Babini M., Paggioro A., Parrini V., Zaccaria M., Clementi S., Gigliuto C., Facondini F., Pastorini S., Munaron S., Calamai I., Bocchi A., Adorni A., Bocci M. G., Cortegiani A., Casalicchio T., Mellea S., Graziani E., Barattini M., Brizio E., Rossi M., Hahn M., Kemmerer N., Strietzel H. F., Dybwik K., Legernaes T., Klepstad P., Olaussen E. B., Olsen K. I., Brresen O. M., Bjorsvik G., Maini S., Fehrle L., Czuczwar M., Krawczyk P., Zietkiewicz M., Nowak L. R., Kotfis K., Cwyl K., Gajdosz R., Biernawska J., Bohatyrewicz Romuald., Gawda R., Grudzien P., Nasilowski P., Popek N., Cyrankiewicz W., Wawrzyniak K., Wnuk M., Maciejewski D., Studzinska D., Zukowski M., Bernas S., Piechota M., Nowak I., Fronczek J., Serwa M., Machala W., Stefaniak J., Wujtewicz M., Maciejewski P., Szymkowiak M., Adamik B., Catorze N., Branco M. C., Barros I., Barros N., Krystopchuk A., Honrado T., Sousa C., Munoz F., Rebelo M., Gomes R., Nunes J., Dias Celeste., Fernandes A. M., Petrisor C., Constantin B., Belskiy V., Boskholov B., Rodriguez E., Rebollo S., Aguilar G., Masdeu G., Jaimes M. I., Mira A. P., Bodi Maria. A., Mendoza J. A. B., Cuenca S. L., Guzman M. H., Rico-Feijoo J., Ibarz M., Alvarez J. T., Kawati R., Sivik J., Nauska J., Smole D., Parenmark F., Lyren J., Rockstroh K., Ryden S., Strinnholm M., Walther S., De Geer L., Nordlund P., Palsson S., Zetterquist H., Nilsson A., Thiringer K., Jungner M., Bark B., Nordling B., Skold H., Brorsson C., Persson S., Bergstrom A., Berkius J., Holmstrom J., van Dijk I., van Lelyveld-Haas L. E. M., Ramnarain D., Jansen T., Nooteboom F., van der Voort P. H. J., Dieperink W., de Waard M. C., Bormans L., Dormans Tom., Dempsey G., Mathew S. J., Raj A. S., Grecu I., Cupitt J., Lawton T., Clark R., Popescu M., Spittle N., Faulkner M., Cowton A., Elloway E., Williams P., Reay M., Chukkambotla S., Kumar R., Al-Subaie N., Kent L., Tamm T., Kajtor I., Burns K., Pugh R., Ostermann M., Kam E., Bowyer H., Smith N., Templeton M., Henning J., Goffin K., Kapoor R., Laha S., Chilton P., Khaliq W., Crayford A., Coetzee S., Tait M., Stoker W., Gimenez M., Pope A., Camsooksai J., Pogson D., Quigley K., Ritzema J., Hormis A., Boulanger C., Balasubramaniam M., Vamplew L., Burt K., Martin D., Craig J., Prowle J., Doyle N., Shelton J., Scott Carmen., Donnison P., Shelton S., Frey C., Ryan C., Spray D., Barnes V., Barnes K., Ridgway S., Saha R., Clark T., Wood J., Bolger C., Bassford C., Lewandowski J., Zhao X., Humphreys S., Dowling S., Richardson N., Burtenshaw A., Stevenson C., Wilcock D., Nalapko Y., Microbes in Health and Disease (MHD), Critical care, Anesthesiology, Peri-operative and Emergency medicine (CAPE), Medical Informatics, APH - Methodology, APH - Quality of Care, de Lange, D, Brinkman, S, Flaatten, H, Boumendil, A, Morandi, A, Andersen, F, Artigas, A, Bertolini, G, Cecconi, M, Christensen, S, Faraldi, L, Fjolner, J, Jung, C, Marsh, B, Favarato, M, Oeyen, S, Ohman, C, Bollen Pinto, B, de Smet, A, Soliman, I, Szczeklik, W, Valentin, A, Watson, X, Zafeiridis, T, Guidet, B, Schmutz, R, Wimmer, F, Eller, P, Joannidis, M, De Buysscher, P, De Neve, N, Swinnen, W, Abraham, P, Hergafi, L, Schefold, J, Biskup, E, Piza, P, Taliadoros, I, Dey, N, Solling, C, Rasmussen, B, Forceville, X, Besch, G, Mentec, H, Michel, P, Mateu, P, Vettoretti, L, Bourenne, J, Marin, N, Guillot, M, Aissaoui, N, Goulenok, C, Thieulot-Rolin, N, Messika, J, Lamhaut, L, Charron, C, Lauten, A, Sacher, A, Brenner, T, Franz, M, Bloos, F, Ebelt, H, Schaller, S, Fuest, K, Rabe, C, Dieck, T, Steiner, S, Graf, T, Nia, A, Janosi, R, Meybohm, P, Simon, P, Utzolino, S, Rahmel, T, Barth, E, Schuster, M, Aidoni, Z, Aloizos, S, Tasioudis, P, Lampiri, K, Zisopoulou, V, Ravani, I, Pagaki, E, Antoniou, A, Katsoulas, T, Kounougeri, A, Marinakis, G, Tsimpoukas, F, Spyropoulou, A, Zygoulis, P, Kyparissi, A, Gupta, M, Gurjar, M, Maji, I, Hayes, I, Kelly, Y, Westbrook, A, Fitzpatrick, G, Maheshwari, D, Motherway, C, Negri, G, Spadaro, S, Nattino, G, Pedeferri, M, Boscolo, A, Rossi, S, Calicchio, G, Cubattoli, L, Di Lascio, G, Barbagallo, M, Berruto, F, Codazzi, D, Bottazzi, A, Fumagalli, P, Negro, G, Lupi, G, Savelli, F, Vulcano, G, Fumagalli, R, Marudi, A, Lefons, U, Lembo, R, Babini, M, Paggioro, A, Parrini, V, Zaccaria, M, Clementi, S, Gigliuto, C, Facondini, F, Pastorini, S, Munaron, S, Calamai, I, Bocchi, A, Adorni, A, Bocci, M, Cortegiani, A, Casalicchio, T, Mellea, S, Graziani, E, Barattini, M, Brizio, E, Rossi, M, Hahn, M, Kemmerer, N, Strietzel, H, Dybwik, K, Legernaes, T, Klepstad, P, Olaussen, E, Olsen, K, Brresen, O, Bjorsvik, G, Maini, S, Fehrle, L, Czuczwar, M, Krawczyk, P, Zietkiewicz, M, Nowak, L, Kotfis, K, Cwyl, K, Gajdosz, R, Biernawska, J, Bohatyrewicz, R, Gawda, R, Grudzien, P, Nasilowski, P, Popek, N, Cyrankiewicz, W, Wawrzyniak, K, Wnuk, M, Maciejewski, D, Studzinska, D, Zukowski, M, Bernas, S, Piechota, M, Nowak, I, Fronczek, J, Serwa, M, Machala, W, Stefaniak, J, Wujtewicz, M, Maciejewski, P, Szymkowiak, M, Adamik, B, Catorze, N, Branco, M, Barros, I, Barros, N, Krystopchuk, A, Honrado, T, Sousa, C, Munoz, F, Rebelo, M, Gomes, R, Nunes, J, Dias, C, Fernandes, A, Petrisor, C, Constantin, B, Belskiy, V, Boskholov, B, Rodriguez, E, Rebollo, S, Aguilar, G, Masdeu, G, Jaimes, M, Mira, A, Bodi, M, Mendoza, J, Cuenca, S, Guzman, M, Rico-Feijoo, J, Ibarz, M, Alvarez, J, Kawati, R, Sivik, J, Nauska, J, Smole, D, Parenmark, F, Lyren, J, Rockstroh, K, Ryden, S, Strinnholm, M, Walther, S, De Geer, L, Nordlund, P, Palsson, S, Zetterquist, H, Nilsson, A, Thiringer, K, Jungner, M, Bark, B, Nordling, B, Skold, H, Brorsson, C, Persson, S, Bergstrom, A, Berkius, J, Holmstrom, J, van Dijk, I, van Lelyveld-Haas, L, Ramnarain, D, Jansen, T, Nooteboom, F, van der Voort, P, Dieperink, W, de Waard, M, Bormans, L, Dormans, T, Dempsey, G, Mathew, S, Raj, A, Grecu, I, Cupitt, J, Lawton, T, Clark, R, Popescu, M, Spittle, N, Faulkner, M, Cowton, A, Elloway, E, Williams, P, Reay, M, Chukkambotla, S, Kumar, R, Al-Subaie, N, Kent, L, Tamm, T, Kajtor, I, Burns, K, Pugh, R, Ostermann, M, Kam, E, Bowyer, H, Smith, N, Templeton, M, Henning, J, Goffin, K, Kapoor, R, Laha, S, Chilton, P, Khaliq, W, Crayford, A, Coetzee, S, Tait, M, Stoker, W, Gimenez, M, Pope, A, Camsooksai, J, Pogson, D, Quigley, K, Ritzema, J, Hormis, A, Boulanger, C, Balasubramaniam, M, Vamplew, L, Burt, K, Martin, D, Craig, J, Prowle, J, Doyle, N, Shelton, J, Scott, C, Donnison, P, Shelton, S, Frey, C, Ryan, C, Spray, D, Barnes, V, Barnes, K, Ridgway, S, Saha, R, Clark, T, Wood, J, Bolger, C, Bassford, C, Lewandowski, J, Zhao, X, Humphreys, S, Dowling, S, Richardson, N, Burtenshaw, A, Stevenson, C, Wilcock, D, Nalapko, Y, de Lange D.W., Brinkman S., Flaatten H., Boumendil A., Morandi A., Andersen F.H., Artigas A., Bertolini G., Cecconi M., Christensen S., Faraldi L., Fjolner J., Jung C., Marsh B., Moreno R., Oeyen S., Ohman C.A., Bollen Pinto B., de Smet A.M.G.A., Soliman I.W., Szczeklik W., Valentin A., Watson X., Zafeiridis T., Guidet B., Schmutz R., Wimmer F., Eller P., Joannidis M., De Buysscher P., De Neve N., Swinnen W., Abraham P., Hergafi L., Schefold Joerg.C., Biskup E., Piza P., Taliadoros I., Dey N., Solling C., Rasmussen B.S., Forceville X., Besch G., Mentec H., Michel P., Mateu P., Vettoretti L., Bourenne J., Marin N., Guillot M., Aissaoui N., Goulenok C., Thieulot-Rolin N., Messika J., Lamhaut L., Charron C., Lauten A., Sacher A.L., Brenner T., Franz M., Bloos F., Ebelt H., Schaller S.J., Fuest Kristina., Rabe C., Dieck T., Steiner S., Graf T., Nia A.M., Janosi R.A., Meybohm P., Simon P., Utzolino S., Rahmel T., Barth E., Schuster M., Aidoni Z., Aloizos S., Tasioudis P., Lampiri K., Zisopoulou V., Ravani I., Pagaki E., Antoniou A., Katsoulas T.A., Kounougeri A., Marinakis G., Tsimpoukas F., Spyropoulou A., Zygoulis P., Kyparissi A., Gupta M., Gurjar M., Maji I.M., Hayes I., Kelly Y., Westbrook A., Fitzpatrick G., Maheshwari D., Motherway C., Negri G., Spadaro S., Nattino G., Pedeferri M., Boscolo A., Rossi S., Calicchio G., Cubattoli L., Di Lascio G., Barbagallo M., Berruto F., Codazzi D., Bottazzi A., Fumagalli P., Negro G., Lupi G., Savelli F., Vulcano Giuseppe.A., Fumagalli R., Marudi A., Lefons U., Lembo R., Babini M., Paggioro A., Parrini V., Zaccaria M., Clementi S., Gigliuto C., Facondini F., Pastorini S., Munaron S., Calamai I., Bocchi A., Adorni A., Bocci M.G., Cortegiani A., Casalicchio T., Mellea S., Graziani E., Barattini M., Brizio E., Rossi M., Hahn M., Kemmerer N., Strietzel H.F., Dybwik K., Legernaes T., Klepstad P., Olaussen E.B., Olsen K.I., Brresen O.M., Bjorsvik G., Maini S., Fehrle L., Czuczwar M., Krawczyk P., Zietkiewicz M., Nowak L.R., Kotfis K., Cwyl K., Gajdosz R., Biernawska J., Bohatyrewicz Romuald., Gawda R., Grudzien P., Nasilowski P., Popek N., Cyrankiewicz W., Wawrzyniak K., Wnuk M., Maciejewski D., Studzinska D., Zukowski M., Bernas S., Piechota M., Nowak I., Fronczek J., Serwa M., Machala W., Stefaniak J., Wujtewicz M., Maciejewski P., Szymkowiak M., Adamik B., Catorze N., Branco M.C., Barros I., Barros N., Krystopchuk A., Honrado T., Sousa C., Munoz F., Rebelo M., Gomes R., Nunes J., Dias Celeste., Fernandes A.M., Petrisor C., Constantin B., Belskiy V., Boskholov B., Rodriguez E., Rebollo S., Aguilar G., Masdeu G., Jaimes M.I., Mira A.P., Bodi Maria.A., Mendoza J.A.B., Cuenca S.L., Guzman M.H., Rico-Feijoo J., Ibarz M., Alvarez J.T., Kawati R., Sivik J., Nauska J., Smole D., Parenmark F., Lyren J., Rockstroh K., Ryden S., Strinnholm M., Walther S., De Geer L., Nordlund P., Palsson S., Zetterquist H., Nilsson A., Thiringer K., Jungner M., Bark B., Nordling B., Skold H., Brorsson C., Persson S., Bergstrom A., Berkius J., Holmstrom J., van Dijk I., van Lelyveld-Haas L.E.M., Ramnarain D., Jansen T., Nooteboom F., van der Voort P.H.J., Dieperink W., de Waard M.C., Bormans L., Dormans Tom., Dempsey G., Mathew S.J., Raj A.S., Grecu I., Cupitt J., Lawton T., Clark R., Popescu M., Spittle N., Faulkner M., Cowton A., Elloway E., Williams P., Reay M., Chukkambotla S., Kumar R., Al-Subaie N., Kent L., Tamm T., Kajtor I., Burns K., Pugh R., Ostermann M., Kam E., Bowyer H., Smith N., Templeton M., Henning J., Goffin K., Kapoor R., Laha S., Chilton P., Khaliq W., Crayford A., Coetzee S., Tait M., Stoker W., Gimenez M., Pope A., Camsooksai J., Pogson D., Quigley K., Ritzema J., Hormis A., Boulanger C., Balasubramaniam M., Vamplew L., Burt K., Martin D., Craig J., Prowle J., Doyle N., Shelton J., Scott Carmen., Donnison P., Shelton S., Frey C., Ryan C., Spray D., Barnes V., Barnes K., Ridgway S., Saha R., Clark T., Wood J., Bolger C., Bassford C., Lewandowski J., Zhao X., Humphreys S., Dowling S., Richardson N., Burtenshaw A., Stevenson C., Wilcock D., Nalapko Y., University Medical Center [Utrecht], University of Amsterdam [Amsterdam] (UvA), Public Health Service of Amsterdam, University of Bergen (UiB), Haukeland University Hospital, Service de Réanimation Médicale [CHU Saint-Antoine], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Norwegian University of Science and Technology [Trondheim] (NTNU), Norwegian University of Science and Technology (NTNU), Centro de Investigación Biomédica en Red Enfermedades Respiratorias (CIBERES), Universitat Autònoma de Barcelona (UAB), Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Aarhus University Hospital, Centro Hospitalar de Lisboa Central E.P.E, Ghent University Hospital, Karolinska University Hospital [Stockholm], Geneva University Hospital (HUG), University Medical Center Groningen [Groningen] (UMCG), Uniwersytet Jagielloński w Krakowie = Jagiellonian University (UJ), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM), VIP1 Study Group (Beitragende*r), and Janosi, Rolf Alexander (Beitragende*r)
Subjects: Male, INTENSIVE-CARE-UNIT, Organ Dysfunction Scores, medicine.medical_treatment, Prognosis, Medizin, DECISION-MAKING, Logistic regression, law.invention, older adult, 0302 clinical medicine, PHYSICIANS, Interquartile range, law, 80 and over, Medicine and Health Sciences, 030212 general & internal medicine, Hospital Mortality, Prospective Studies, Prospective cohort study, older adults, Aged, 80 and over, predict, ddc:617, Respiration, [SDV.MHEP.GEG]Life Sciences [q-bio]/Human health and pathology/Geriatry and gerontology, Brief Report, Intensive care unit, ADMISSION, 3. Good health, Europe, Hospitalization, Intensive Care Units, Brier score, Older adults, Artificial, Female, prognosi, medicine.medical_specialty, critical care, model, prognosis, Humans, Respiration, Artificial, 03 medical and health sciences, Intensive care, medicine, Journal Article, ILL ELDERLY-PATIENTS, Renal replacement therapy, Aged, Receiver operating characteristic, business.industry, 030208 emergency & critical care medicine, Emergency medicine, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Brief Reports, Geriatrics and Gerontology, business
Abstract: OBJECTIVES To develop a scoring system model that predicts mortality within 30 days of admission of patients older than 80 years admitted to intensive care units (ICUs). DESIGN Prospective cohort study. SETTING A total of 306 ICUs from 24 European countries. PARTICIPANTS Older adults admitted to European ICUs (N = 3730; median age = 84 years [interquartile range = 81‐87 y]; 51.8% male). MEASUREMENTS Overall, 24 variables available during ICU admission were included as potential predictive variables. Multivariable logistic regression was used to identify independent predictors of 30‐day mortality. Model sensitivity, specificity, and accuracy were evaluated with receiver operating characteristic curves. RESULTS The 30‐day‐mortality was 1562 (41.9%). In multivariable analysis, these variables were selected as independent predictors of mortality: age, sex, ICU admission diagnosis, Clinical Frailty Scale, Sequential Organ Failure Score, invasive mechanical ventilation, and renal replacement therapy. The discrimination, accuracy, and calibration of the model were good: the area under the curve for a score of 10 or higher was .80, and the Brier score was .18. At a cut point of 10 or higher (75% of all patients), the model predicts 30‐day mortality in 91.1% of all patients who die. CONCLUSION A predictive model of cumulative events predicts 30‐day mortality in patients older than 80 years admitted to ICUs. Future studies should include other potential predictor variables including functional status, presence of advance care plans, and assessment of each patient's decision‐making capacity. © 2019 The Authors. Journal of the American Geriatrics Society published by Wiley Periodicals, Inc. on behalf of The American Geriatrics Society. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
Published: 2019
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39. Correction to: Withholding or withdrawing of life-sustaining therapy in older adults (≥ 80 years) admitted to the intensive care unit (Intensive Care Medicine, (2018), 44, 7, (1027-1038), 10.1007/s00134-018-5196-7)

Author: Guidet B., Flaatten H., Boumendil A., Morandi A., Andersen F. H., Artigas A., Bertolini G., Cecconi M., Christensen S., Faraldi L., Fjolner J., Jung C., Marsh B., Moreno R., Oeyen S., Ohman C. A., Pinto B. B., Soliman I. W., Szczeklik W., Valentin A., Watson X., Zafeiridis T., De Lange D. W., Schmutz R., Wimmer F., Eller P., Zotter K., De Buysscher P., De Neve N., Swinnen W., Taliadoros I., Piza P., Dey N., Solling C., Rasmussen B. S., Forceville X., Besch G., Mentec H., Michel P., Mateu P., Vettoretti L., Bourenne J., Marin N., Guillot M., Aissaoui N., Goulenok C., Thieulot-Rolin N., Messika J., Lamhaut L., Charron C., Lauten A., Sacher A. L., Brenner T., Franz M., Bloos F., Ebelt H., Schaller S. J., Fuest K., Rabe C., Dieck T., Steiner S., Graf T., Nia A. M., Janosi R. A., Simon P., Utzolino S., Rahmel T., Barth E., Schuster M., Meybohm P., Aidoni Z., Aloizos S., Tasioudis P., Lampiri K., Zisopoulou V., Ravani I., Pagaki E., Antoniou A., Katsoulas T. A., Kounougeri A., Marinakis G., Tsimpoukas F., Spyropoulou A., Zygoulis P., Kyparissi A., Gupta M., Gurjar M., Maji I. M., Hayes I., Kelly Y., Westbrook A., Fitzpatrick G., Maheshwari D., Motherway C., Negri G., Spadaro S., Nattino G., Pedeferri M., Boscolo A., Rossi S., Calicchio G., Cubattoli L., Di Lascio G., Barbagallo M., Berruto F., Codazzi D., Bottazzi A., Fumagalli P., Negro G., Lupi G., Savelli F., Vulcano G. A., Fumagalli R., Marudi A., Lefons U., Lembo R., Babini M., Paggioro A., Parrini V., Zaccaria M., Clementi S., Gigliuto C., Facondini F., Pastorini S., Munaron S., Calamai I., Bocchi A., Adorni A., Bocci M. G., Cortegiani A., Casalicchio T., Mellea S., Graziani E., Barattini M., Brizio E., Rossi M., Hahn M., Kemmerer N., Strietzel H. F., Dybwik K., Legernaes T., Klepstad P., Olaussen E. B., Olsen K. I., Brresen O. M., Bjorsvik G., Maini S., Fehrle L., Czuczwar M., Krawczyk P., Zietkiewicz M., Nowak L. R., Kotfis K., Cwyl K., Gajdosz R., Biernawska J., Bohatyrewicz R., Gawda R., Grudzien P., Nasilowski P., Popek N., Cyrankiewicz W., Wawrzyniak K., Wnuk M., Maciejewski D., Studzinska D., Zukowski M., Bernas S., Piechota M., Nowak I., Fronczek J., Serwa M., Machala W., Stefaniak J., Wujtewicz M., Maciejewski P., Szymkowiak M., Adamik B., Catorze N., Branco M. C., Barros I., Barros N., Krystopchuk A., Honrado T., Sousa C., Munoz F., Rebelo M., Gomes R., Nunes J., dias C., Fernandes A. M., Petrisor C., Constantin B., Belskiy V., Boskholov B., Rodriguez E., Rebollo S., Aguilar G., Masdeu G., Jaimes M. I., Mira A. P., Bodi M. A., Barea Mendoza J. A., Lopez-Cuenca S., Guzman M. H., Rico-Feijoo J., Ibarz M., Alvarez J. T., Kawati R., Sivik J., Nauska J., Smole D., Parenmark F., Lyren J., Rockstroh K., Ryden S., Spangfors M., Strinnholm M., Walther S., De Geer L., Nordlund P., Palsson S., Zetterquist H., Nilsson A., Thiringer K., Jungner M., Bark B., Nordling B., Skold H., Brorsson C., Persson S., Bergstrom A., Berkius J., Holmstrom J., Abraham P., Hergafi L., Schefold J. C., Biskup E., van Dijk I., van Lelyveld-Haas L. E. M., Ramnarain D., Jansen T., Nooteboom F., van der Voort P. H. J., de Lange D., Dieperink W., de Waard M. C., de Smet A. G., Bormans L., Dormans T., Dempsey G., Mathew S. J., Raj A. S., Grecu I., Cupitt J., Lawton T., Clark R., Popescu M., Spittle N., Faulkner M., Cowton A., Elloway E., Williams P., Reay M., Chukkambotla S., Kumar R., Al-Subaie N., Kent L., Tamm T., Kajtor I., Burns K., Pugh R., Ostermann M., Kam E., Bowyer H., Smith N., Templeton M., Henning J., Goffin K., Kapoor R., Laha S., Chilton P., Khaliq W., Crayford A., Coetzee S., Tait M., Stoker W., Gimenez M., Pope A., Camsooksai J., Pogson D., Quigley K., Ritzema J., Hormis A., Boulanger C., Balasubramaniam M., Vamplew L., Burt K., Martin D., Craig J., Prowle J., Doyle N., Shelton J., Scott C., Donnison P., Shelton S., Frey C., Ryan C., Spray D., Barnes V., Barnes K., Ridgway S., Saha R., Clark T., Wood J., Bolger C., Bassford C., lewandowski J., Zhao X., Humphreys S., Dowling S., Richardson N., Burtenshaw A., Stevenson C., Wilcock D., Nalapko Y., Guidet, B, Flaatten, H, Boumendil, A, Morandi, A, Andersen, F, Artigas, A, Bertolini, G, Cecconi, M, Christensen, S, Faraldi, L, Fjolner, J, Jung, C, Marsh, B, Moreno, R, Oeyen, S, Ohman, C, Pinto, B, Soliman, I, Szczeklik, W, Valentin, A, Watson, X, Zafeiridis, T, De Lange, D, Schmutz, R, Wimmer, F, Eller, P, Zotter, K, De Buysscher, P, De Neve, N, Swinnen, W, Taliadoros, I, Piza, P, Dey, N, Solling, C, Rasmussen, B, Forceville, X, Besch, G, Mentec, H, Michel, P, Mateu, P, Vettoretti, L, Bourenne, J, Marin, N, Guillot, M, Aissaoui, N, Goulenok, C, Thieulot-Rolin, N, Messika, J, Lamhaut, L, Charron, C, Lauten, A, Sacher, A, Brenner, T, Franz, M, Bloos, F, Ebelt, H, Schaller, S, Fuest, K, Rabe, C, Dieck, T, Steiner, S, Graf, T, Nia, A, Janosi, R, Simon, P, Utzolino, S, Rahmel, T, Barth, E, Schuster, M, Meybohm, P, Aidoni, Z, Aloizos, S, Tasioudis, P, Lampiri, K, Zisopoulou, V, Ravani, I, Pagaki, E, Antoniou, A, Katsoulas, T, Kounougeri, A, Marinakis, G, Tsimpoukas, F, Spyropoulou, A, Zygoulis, P, Kyparissi, A, Gupta, M, Gurjar, M, Maji, I, Hayes, I, Kelly, Y, Westbrook, A, Fitzpatrick, G, Maheshwari, D, Motherway, C, Negri, G, Spadaro, S, Nattino, G, Pedeferri, M, Boscolo, A, Rossi, S, Calicchio, G, Cubattoli, L, Di Lascio, G, Barbagallo, M, Berruto, F, Codazzi, D, Bottazzi, A, Fumagalli, P, Negro, G, Lupi, G, Savelli, F, Vulcano, G, Fumagalli, R, Marudi, A, Lefons, U, Lembo, R, Babini, M, Paggioro, A, Parrini, V, Zaccaria, M, Clementi, S, Gigliuto, C, Facondini, F, Pastorini, S, Munaron, S, Calamai, I, Bocchi, A, Adorni, A, Bocci, M, Cortegiani, A, Casalicchio, T, Mellea, S, Graziani, E, Barattini, M, Brizio, E, Rossi, M, Hahn, M, Kemmerer, N, Strietzel, H, Dybwik, K, Legernaes, T, Klepstad, P, Olaussen, E, Olsen, K, Brresen, O, Bjorsvik, G, Maini, S, Fehrle, L, Czuczwar, M, Krawczyk, P, Zietkiewicz, M, Nowak, L, Kotfis, K, Cwyl, K, Gajdosz, R, Biernawska, J, Bohatyrewicz, R, Gawda, R, Grudzien, P, Nasilowski, P, Popek, N, Cyrankiewicz, W, Wawrzyniak, K, Wnuk, M, Maciejewski, D, Studzinska, D, Zukowski, M, Bernas, S, Piechota, M, Nowak, I, Fronczek, J, Serwa, M, Machala, W, Stefaniak, J, Wujtewicz, M, Maciejewski, P, Szymkowiak, M, Adamik, B, Catorze, N, Branco, M, Barros, I, Barros, N, Krystopchuk, A, Honrado, T, Sousa, C, Munoz, F, Rebelo, M, Gomes, R, Nunes, J, Dias, C, Fernandes, A, Petrisor, C, Constantin, B, Belskiy, V, Boskholov, B, Rodriguez, E, Rebollo, S, Aguilar, G, Masdeu, G, Jaimes, M, Mira, A, Bodi, M, Barea Mendoza, J, Lopez-Cuenca, S, Guzman, M, Rico-Feijoo, J, Ibarz, M, Alvarez, J, Kawati, R, Sivik, J, Nauska, J, Smole, D, Parenmark, F, Lyren, J, Rockstroh, K, Ryden, S, Spangfors, M, Strinnholm, M, Walther, S, De Geer, L, Nordlund, P, Palsson, S, Zetterquist, H, Nilsson, A, Thiringer, K, Jungner, M, Bark, B, Nordling, B, Skold, H, Brorsson, C, Persson, S, Bergstrom, A, Berkius, J, Holmstrom, J, Abraham, P, Hergafi, L, Schefold, J, Biskup, E, van Dijk, I, van Lelyveld-Haas, L, Ramnarain, D, Jansen, T, Nooteboom, F, van der Voort, P, de Lange, D, Dieperink, W, de Waard, M, de Smet, A, Bormans, L, Dormans, T, Dempsey, G, Mathew, S, Raj, A, Grecu, I, Cupitt, J, Lawton, T, Clark, R, Popescu, M, Spittle, N, Faulkner, M, Cowton, A, Elloway, E, Williams, P, Reay, M, Chukkambotla, S, Kumar, R, Al-Subaie, N, Kent, L, Tamm, T, Kajtor, I, Burns, K, Pugh, R, Ostermann, M, Kam, E, Bowyer, H, Smith, N, Templeton, M, Henning, J, Goffin, K, Kapoor, R, Laha, S, Chilton, P, Khaliq, W, Crayford, A, Coetzee, S, Tait, M, Stoker, W, Gimenez, M, Pope, A, Camsooksai, J, Pogson, D, Quigley, K, Ritzema, J, Hormis, A, Boulanger, C, Balasubramaniam, M, Vamplew, L, Burt, K, Martin, D, Craig, J, Prowle, J, Doyle, N, Shelton, J, Scott, C, Donnison, P, Shelton, S, Frey, C, Ryan, C, Spray, D, Barnes, V, Barnes, K, Ridgway, S, Saha, R, Clark, T, Wood, J, Bolger, C, Bassford, C, Lewandowski, J, Zhao, X, Humphreys, S, Dowling, S, Richardson, N, Burtenshaw, A, Stevenson, C, Wilcock, D, Nalapko, Y, Guidet B., Flaatten H., Boumendil A., Morandi A., Andersen F.H., Artigas A., Bertolini G., Cecconi M., Christensen S., Faraldi L., Fjolner J., Jung C., Marsh B., Moreno R., Oeyen S., Ohman C.A., Pinto B.B., Soliman I.W., Szczeklik W., Valentin A., Watson X., Zafeiridis T., De Lange D.W., Schmutz R., Wimmer F., Eller P., Zotter K., De Buysscher P., De Neve N., Swinnen W., Taliadoros I., Piza P., Dey N., Solling C., Rasmussen B.S., Forceville X., Besch G., Mentec H., Michel P., Mateu P., Vettoretti L., Bourenne J., Marin N., Guillot M., Aissaoui N., Goulenok C., Thieulot-Rolin N., Messika J., Lamhaut L., Charron C., Lauten A., Sacher A.L., Brenner T., Franz M., Bloos F., Ebelt H., Schaller S.J., Fuest K., Rabe C., Dieck T., Steiner S., Graf T., Nia A.M., Janosi R.A., Simon P., Utzolino S., Rahmel T., Barth E., Schuster M., Meybohm P., Aidoni Z., Aloizos S., Tasioudis P., Lampiri K., Zisopoulou V., Ravani I., Pagaki E., Antoniou A., Katsoulas T.A., Kounougeri A., Marinakis G., Tsimpoukas F., Spyropoulou A., Zygoulis P., Kyparissi A., Gupta M., Gurjar M., Maji I.M., Hayes I., Kelly Y., Westbrook A., Fitzpatrick G., Maheshwari D., Motherway C., Negri G., Spadaro S., Nattino G., Pedeferri M., Boscolo A., Rossi S., Calicchio G., Cubattoli L., Di Lascio G., Barbagallo M., Berruto F., Codazzi D., Bottazzi A., Fumagalli P., Negro G., Lupi G., Savelli F., Vulcano G.A., Fumagalli R., Marudi A., Lefons U., Lembo R., Babini M., Paggioro A., Parrini V., Zaccaria M., Clementi S., Gigliuto C., Facondini F., Pastorini S., Munaron S., Calamai I., Bocchi A., Adorni A., Bocci M.G., Cortegiani A., Casalicchio T., Mellea S., Graziani E., Barattini M., Brizio E., Rossi M., Hahn M., Kemmerer N., Strietzel H.F., Dybwik K., Legernaes T., Klepstad P., Olaussen E.B., Olsen K.I., Brresen O.M., Bjorsvik G., Maini S., Fehrle L., Czuczwar M., Krawczyk P., Zietkiewicz M., Nowak L.R., Kotfis K., Cwyl K., Gajdosz R., Biernawska J., Bohatyrewicz R., Gawda R., Grudzien P., Nasilowski P., Popek N., Cyrankiewicz W., Wawrzyniak K., Wnuk M., Maciejewski D., Studzinska D., Zukowski M., Bernas S., Piechota M., Nowak I., Fronczek J., Serwa M., Machala W., Stefaniak J., Wujtewicz M., Maciejewski P., Szymkowiak M., Adamik B., Catorze N., Branco M.C., Barros I., Barros N., Krystopchuk A., Honrado T., Sousa C., Munoz F., Rebelo M., Gomes R., Nunes J., dias C., Fernandes A.M., Petrisor C., Constantin B., Belskiy V., Boskholov B., Rodriguez E., Rebollo S., Aguilar G., Masdeu G., Jaimes M.I., Mira A.P., Bodi M.A., Barea Mendoza J.A., Lopez-Cuenca S., Guzman M.H., Rico-Feijoo J., Ibarz M., Alvarez J.T., Kawati R., Sivik J., Nauska J., Smole D., Parenmark F., Lyren J., Rockstroh K., Ryden S., Spangfors M., Strinnholm M., Walther S., De Geer L., Nordlund P., Palsson S., Zetterquist H., Nilsson A., Thiringer K., Jungner M., Bark B., Nordling B., Skold H., Brorsson C., Persson S., Bergstrom A., Berkius J., Holmstrom J., Abraham P., Hergafi L., Schefold J.C., Biskup E., van Dijk I., van Lelyveld-Haas L.E.M., Ramnarain D., Jansen T., Nooteboom F., van der Voort P.H.J., de Lange D., Dieperink W., de Waard M.C., de Smet A.G., Bormans L., Dormans T., Dempsey G., Mathew S.J., Raj A.S., Grecu I., Cupitt J., Lawton T., Clark R., Popescu M., Spittle N., Faulkner M., Cowton A., Elloway E., Williams P., Reay M., Chukkambotla S., Kumar R., Al-Subaie N., Kent L., Tamm T., Kajtor I., Burns K., Pugh R., Ostermann M., Kam E., Bowyer H., Smith N., Templeton M., Henning J., Goffin K., Kapoor R., Laha S., Chilton P., Khaliq W., Crayford A., Coetzee S., Tait M., Stoker W., Gimenez M., Pope A., Camsooksai J., Pogson D., Quigley K., Ritzema J., Hormis A., Boulanger C., Balasubramaniam M., Vamplew L., Burt K., Martin D., Craig J., Prowle J., Doyle N., Shelton J., Scott C., Donnison P., Shelton S., Frey C., Ryan C., Spray D., Barnes V., Barnes K., Ridgway S., Saha R., Clark T., Wood J., Bolger C., Bassford C., lewandowski J., Zhao X., Humphreys S., Dowling S., Richardson N., Burtenshaw A., Stevenson C., Wilcock D., and Nalapko Y.
Subjects: End of life, ICU, withdrawing
Abstract: In the original publication Dr Patrick Meybohm of the Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy, Frankfurt University Hospital, Frankfurt, Germany was inadvertently omitted from the list of investigators.
Published: 2018

40. Markers and indices of infection in critically ill patients

Author: de Jong, E., Girbes, Armand, Beishuizen, Albertus, de Lange, Dylan W, Intensive care medicine, AII - Infectious diseases, ACS - Diabetes & metabolism, Girbes, A.R.J., Beishuizen, A., and De Lange, D.W.
Subjects: critically ill, Intensive Care, Biomarkers, procalcitonin
Published: 2017

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