Search

Your search keyword '"De Jong, Menno D"' showing total 1,096 results
Start Over Author "De Jong, Menno D"
1,096 results on '"De Jong, Menno D"'

1. Determinants of epidemic size and the impacts of lulls in seasonal influenza virus circulation

Author

de Jong, Simon P. J., Felix Garza, Zandra C., Gibson, Joseph C., van Leeuwen, Sarah, de Vries, Robert P., Boons, Geert-Jan, van Hoesel, Marliek, de Haan, Karen, van Groeningen, Laura E., Hulme, Katina D., van Willigen, Hugo D. G., Wynberg, Elke, de Bree, Godelieve J., Matser, Amy, Bakker, Margreet, van der Hoek, Lia, Prins, Maria, Kootstra, Neeltje A., Eggink, Dirk, Nichols, Brooke E., Han, Alvin X., de Jong, Menno D., and Russell, Colin A.

Published
2024
Full Text
View/download PDF

2. How International Students' Acculturation Motivation Develops over Time in an International Learning Environment: A Longitudinal Study

Author

Aladegbaiye, Adedapo T., De Jong, Menno D. T., and Beldad, Ardion

Abstract

This research investigates how the acculturation motivation (AM) of new international students develops over time, and which factors play a role in this development. In the context of a Dutch university, we interviewed 25 students from 17 countries three times over eight months. The findings show that initial AM levels can be categorized as high or low. These AM levels evolved into four patterns in the three interview rounds: high-low-low, high-low-high, low-high-low, and low-high-high. After four months, twelve factors emerged as affecting the development of students' AM levels. Prominent factors were prior international experience, language issues, and perceived student identities. After eight months, seven additional factors contributed to subsequent changes in students' AM levels, including the perceived international learning environment, friendship networks, and teachers' role in intercultural contacts. Findings suggest that universities can introduce interventions which could improve international students' acculturation experiences at specific times.

Published
2022

3. To Share or not to Share: Deciding Factors for (not) Sharing Geospatial Data in Ugandan Health Sector Organizations

Author

Nyemera, Beatrice Winnie, de Jong, Menno D. T., Beldad, Ardion, Froehlich, Annette, Series Editor, Heinzmann, Dirk, Associate Editor, Aschbacher, Josef, Advisory Editor, Caballero León, Carlos, Advisory Editor, Consolmagno, Guy, Advisory Editor, de Dalmau, Juan, Advisory Editor, El Hadani, Driss, Advisory Editor, Gaggero, Marta, Advisory Editor, Gashut, El Hadi, Advisory Editor, Grosner, Ian, Advisory Editor, Hanlon, Michelle, Advisory Editor, Jide-Omole, Ayomide A., Advisory Editor, João, Zolana, Advisory Editor, Kriening, Torsten, Advisory Editor, Menicocci, Félix Clementino, Advisory Editor, Mostert, Sias, Advisory Editor, Munsami, Val, Advisory Editor, Olsen, Greg, Advisory Editor, Oniosun, Temidayo, Advisory Editor, Prado Alegre, Elvira, Advisory Editor, Romero Vázquez, Fermín, Advisory Editor, Schrogl, Kai-Uwe, Advisory Editor, van Zyl, Robert, Advisory Editor, Potel, Jossam, editor, Labbassi, Kamal, editor, Tesfamichael, Solomon, editor, Annegarn, Harold, editor, Kufoniyi, Jide, editor, and Wade, Souleye, editor

Published
2024
Full Text
View/download PDF

4. 'Honeymoon' Acculturation Orientation Preferences of New International Students: Influence of Intercultural Attitudes and Intentions in an International Learning Environment

Author

Aladegbaiye, Adedapo T., de Jong, Menno D. T., and Beldad, Ardion D.

Abstract

Research routinely suggests that international students often struggle in engaging with other student groups. This study, therefore, examines to what extent and how the intercultural attitudes and intentions of new international students in three Dutch educational institutions related to their acculturation orientation preferences (AOPs) during the "honeymoon" stage. Their AOPs were investigated across four social contact domains: living, schoolwork, friendships, and general interactions. Using structural equation modelling, results from 198 respondents indicate that intercultural intentions predicted their AOPs, with multicultural integration the most preferred strategy and marginalization the least preferred. Results of a simple mediation analysis show that intercultural intentions mediated the effect of intercultural attitudes for students adopting multicultural integration and separation strategies. Interview findings from 25 participants indicate that students sometimes adopted different orientations across the social contact domains. Internationally oriented higher education institutions should further support new students in their planning for intercultural interactions.

Published
2023
Full Text
View/download PDF

6. Lack of association between classical HLA genes and asymptomatic SARS-CoV-2 infection

Author

Abel, Laurent, Aiuti, Alessandro, Al-Muhsen, Saleh, Al-Mulla, Fahd, Amara, Ali, Anderson, Mark S., Andreakos, Evangelos, Arias, Andrés A., Arkin, Lisa M., Feldman, Hagit Baris, Bastard, Paul, Belot, Alexandre, Biggs, Catherine M., Bogunovic, Dusan, Bolze, Alexandre, Bondarenko, Anastasiia, Borghesi, Alessandro, Bousfiha, Ahmed A., Brodin, Petter, Bryceson, Yenan, Butte, Manish J., Casanova, Jean-Laurent, Casari, Giorgio, Christodoulou, John, Cobat, Aurélie, Colobran, Roger, Condino-Neto, Antonio, Constantinescu, Stefan N., Cooper, Megan A., Dalgard, Clifton L., Desai, Murkesh, Drolet, Beth A., Duval, Xavier, El Baghdadi, Jamila, Eloy, Philippine, Espinosa-Padilla, Sara, Fellay, Jacques, Flores, Carlos, Franco, José Luis, Froidure, Antoine, Gorochov, Guy, Gregersen, Peter K., Grimbacher, Bodo, Haerynck, Filomeen, Hagin, David, Halwani, Rabih, Hammarström, Lennart, Heath, James R., Hsieh, Elena W.Y., Husebye, Eystein, Imai, Kohsuke, Itan, Yuval, Jouanguy, Emmanuelle, Kaja, Elżbieta, Karamitros, Timokratis, Kisand, Kai, Ku, Cheng-Lung, Lau, Yu-Lung, Ling, Yun, Lucas, Carrie L., Maniatis, Tom, Mansouri, Davood, Maródi, László, Mentré, France, Meyts, Isabelle, Milner, Joshua D., Mironska, Kristina, Mogensen, Trine H., Morio, Tomohiro, Ng, Lisa F.P., Notarangelo, Luigi D., Novelli, Antonio, Novelli, Giuseppe, O'Farrelly, Cliona, Okada, Satoshi, Okamoto, Keisuke, Ozcelik, Tayfun, Pan-Hammarström, Qiang, Pape, Jean W., Perez de Diego, Rebeca, Perez-Tur, Jordi, Perlin, David S., Pesole, Graziano, Planas, Anna M., Prando, Carolina, Pujol, Aurora, Puel, Anne, Quintana-Murci, Lluis, Ramaswamy, Sathishkumar, Renia, Laurent, Resnick, Igor, Rodríguez-Gallego, Carlos, Sancho-Shimizu, Vanessa, Sediva, Anna, Seppänen, Mikko R.J., Shahrooei, Mohammad, Shcherbina, Anna, Slaby, Ondrej, Snow, Andrew L., Soler-Palacín, Pere, Soumelis, Vassili, Spaan, András N., Tancevski, Ivan, Tangye, Stuart G., Tayoun, Ahmad Abou, Temel, Şehime Gülsün, Thorball, Christian, Tiberghien, Pierre, Trouillet-Assant, Sophie, Turvey, Stuart E., Uddin, K. M. Furkan, Uddin, Mohammed J., van de Beek, Diederik, Vinh, Donald C., von Bernuth, Horst, Wauters, Joost, Zatz, Mayana, Zawadzki, Pawel, Zhang, Qian, Zhang, Shen-Ying, Bureau, Serge, Vacher, Yannick, Gysembergh-Houal, Anne, Demerville, Lauren, Benleulmi-Chaachoua, Abla, Abad, Sebastien, Abassi, Radhiya, Abdellaoui, Abdelrafie, Abdelmalek, Abdelkrim, Abdoul, Hendy, Abergel, Helene, Abeud, Fariza, Abgrall, Sophie, Abisror, Noemie, Adechian, Marylise, Aderdour, Nordine, Admane, Hakeem Farid, Adnet, Frederic, Afritt, Sara, Agostini, Helene, Aguilar, Claire, Agut, Sophie, Aiello, Tommaso Francesco, Kaci, Marc Ait, Oufella, Hafid Ait, Ajeenthiravasan, Gokula, Alauzy, Virginie, Alby-Laurent, Fanny, Allard, Lucie, Alyanakian, Marie-Alexandra, Borrero, Blanca Amador, Amam, Sabrina, Amrouche, Lucile, Andronikof, Marc, Anglicheau, Dany, Anguel, Nadia, Annane, Djillali, Aounzou, Mohammed, Aparicio, Caroline, Aratus, Gladys, Arlet, Jean-Benoit, Arzoine, Jeremy, Aslangul, Elisabeth, Assefi, Mona, Aubry, Adeline, Audiffred, Laetitia, Audureau, Etienne, Auger, Christelle Nathalie, Auregan, Jean-Charles, Awotar, Celine, Milla, Sonia Ayllon, Azan, Delphine, Azemar, Laurene, Azzouguen, Billal, Elrufaai, Marwa Bachir, Badsi, Aïda, Bakouboula, Prissile, Balcerowiak, Coline, Balde, Fanta, Baldivia, Elodie, Bangamingo, Eliane-Flore, Baptiste, Amandine, Baran-Marszak, Fanny, Barau, Caroline, Barget, Nathalie, Baronnet, Flore, Barthelemy, Romain, Baudel, Jean-Luc, Baudry, Camille, Baudry, Elodie, Beaugerie, Laurent, Belamri, Adel, Belaube, Nicolas, Belilita, Rhida, Bellassen, Pierre, Belmokhtar, Rawan, Beltran, Isabel, Benainous, Ruben, Benallaoua, Mourad, Benamouzig, Robert, Benbara, Amélie, Benhida, Jaouad, Benkhelouf, Anis, Benlagha, Jihene, Benmostafa, Chahinez, Benothmane, Skander, Bentifraouine, Miassa, Berard, Laurence, Bernier, Quentin, Berti, Enora, Bertier, Astrid, Berton, Laure, Bessis, Simon, Beurton, Alexandra, Bianco, Celine, Bianquis, Clara, Bidar, Frank, Blanche, Philippe, Blayau, Clarisse, Bleibtreu, Alexandre, Blin, Emmanuelle, Bloch-Queyrat, Coralie, Boissier, Marie-Christophe, Bollens, Diane, Bolzoni, Marion, Bompard, Rudy pierre, Bonnet, Nicolas, Bonnouvrier, Justine, Botha, Shirmonecrystal, Boucenna, Wissam, Bouchama, Fatiha, Bouchaud, Olivier, Bouchghoul, Hanane, Boudjebla, Taoueslylia, Boudjema, Noel, Bouffard, Catherine, Bougle, Adrien, Bouguerra, Meriem, Bouras, Leila, Bourcier, Agnes, Durand, Anne Bourgarit, Bourrier, Anne, Bouscarat, Fabrice, Bouvry, Diane, Bouziri, Nesrine, Bouzrara, Ons, Bribier, Sarah, Brugier, Delphine, Brunel, Melanie, Bui, Eida, Buisson, Anne, Bukreyeva, Iryna, Bureau, Côme, Cadranel, Jacques, Cailhol, Johann, Calin, Ruxandra, Vega, Clara Campos, Canavaggio, Pauline, Cancella, Marta, Cantin, Delphine, Cao, Albert, Carbillon, Lionel, Carlier, Nicolas, Cassard, Clementine, Castor, Guylaine, Cauchy, Marion, Cha, Olivier, Chaigne, Benjamin, Challal, Salima, Champion, Karine, Chariot, Patrick, Chas, Julie, Chauveau, Simon, Chauvin, Anthony, Chauvin, Clement, Chavarot, Nathalie, Chebbout, Kamélia, Cherai, Mustapha, Cherubini, Ilaria, Chevalier, Amelie, Chiarabini, Thibault, Chinet, Thierry, Chocron, Richard, Choinier, Pascaline, Chommeloux, Juliette, Choquet, Christophe, Choupeaux, Laure, Chousterman, Benjamin, Ciocan, Dragosmarius, Clarke, Ada, Clavere, Gaëlle, Clavier, Florian, Clement, Karine, Clerc, Sebastien, Cohen, Yves, Cohen, Fleur, Cohen, Adrien, Coilly, Audrey, Colboc, Hester, Colin, Pauline, Collet, Magalie, Comarmond, Chloé, Combacon, Emeline, Combes, Alain, Comparon, Celine, Constantin, Jean-Michel, Cordel, Hugues, Cordier, Anne-Gael, Costantini, Adrien, Chalumeau, Nathalie Costedoat, Couffignal, Camille, Coupeau, Doriane, Creange, Alain, Lamarre, Yannie Cuvillier, Da Silveira, Charlène, Guibal El Kayani, Sandrine Dautheville, De Castro, Nathalie, De Rycke, Yann, Del Pozo, Lucie, Delannoy, Quentin, Delay, Mathieu, Deleris, Robin, Delforge, Juliette, Delphine, Laëtitia, Demare, Noemie, Demeret, Sophie, Demoule, Alexandre, Deniau, Aurore, Depret, François, Derolez, Sophie, Derradji, Ouda, Derridj, Nawal, Descamps, Vincent, Deschamps, Lydia, Desconclois, Celine, Desnos, Cyrielle, Desongins, Karine, Dhote, Robin, Diallo, Benjamin, Didier, Morgane, Diemer, Myriam, Diez, Stephane, Djadi-Prat, Juliette, Djamouri Monnory, Fatima-Zohra, Djebara, Siham, Djebra, Naoual, Djietcheu, Minette, Djillali, Hadjer, Djouadi, Nouara, Donneger, Severine, Santos, Catarina Dos, Dournon, Nathalie, Dres, Martin, Droctove, Laura, Drogrey, Marie, Dropy, Margot, Drouet, Elodie, Dubosq, Valérie, Dubreucq, Evelyne, Dubus, Estelle, Duchemann, Boris, Duchenoy, Thibault, Dudoignon, Emmanuel, Dufau, Romain, Dumas, Florence, Duran, Clara, Duron, Emmanuelle, Durrbach, Antoine, Duvivier, Claudine, Ebstein, Nathan, El Khalifa, Jihane, Elabbadi, Alexandre, Elie, Caroline, Ernotte, Gabriel, Esling, Anne, Etienne, Martin, Eyer, Xavier, Fartoukh, Muriel Sarah, Fayali, Takoua, Fermaut, Marion, Fiorentino, Arianna, Fliss, Souha, Fournier, Marie-Céline, Fournier, Benjamin, Francois, Hélène, Freynet, Olivia, Frigout, Yvann, Fromont, Isaure, Fuentes, Axelle, Furet, Thomas, Galand, Joris, Garnier, Marc, Gaubert, Agnes, Gaudry, Stéphane, Gaugain, Samuel, Gauthier, Damien, Gautier, Maxime, Georgin-Lavialle, Sophie, Geromin, Daniela, Ghalayini, Mohamed, Ghaleh, Bijan, Ghezal, Myriam, Gibelin, Aude, Gimeno, Linda, Girard, Benoit, Leprieur, Bénédicte Giroux, Gomes, Doryan, Gomes-Pires, Elisabete, Gouge, Anne, Gouja, Amel, Goulet, Helene, Goupil, Sylvain, De Bouille, Jeanne Goupil, Gras, Julien, Greffe, Segolene, Grimaldi, Lamiae, Guedeney, Paul, Guidet, Bertrand, Guillo, Matthias, Gulczynski, Mariechristelle, Hadjam, Tassadit, Haguenauer, Didier, Hammal, Soumeya, Hammoudi, Nadjib, Hanon, Olivier, Harrois, Anarole, Hausfater, Pierre, Hautem, Coraline, Hekimian, Guillaume, Heming, Nicholas, Hermine, Olivier, Ho, Sylvie, Houllier, Marie, Huot, Benjamin, Huscenot, Tessa, Saied, Wafa Ibn, Ikherbane, Ghilas, Imarazene, Meriem, Ingiliz, Patrick, Iratni, Lina, Jaureguiberry, Stephane, Jean-Marc, Jean-Francois, Jeyarajasingham, Deleena, Jouany, Pauline, Jouis, Veronique, Jourdaine, Clement, Kafif, Ouifiya, Kallala, Rim, Katsahian, Sandrine, Kelesyan, Lilit, Keo, Vixra, Ketz, Flora, Khamis, Warda, Khelili, Enfel, Khellaf, Mehdi, Kotokpo Youkou, Christy Gaëlla, Kounis, Ilias, Kpalma, Gaelle, Krause, Jessica, Labbe, Vincent, Lacombe, Karine, Lacorte, Jean-Marc, Lafont, Anne Gaelle, Lafont, Emmanuel, Lagha, Lynda, Lamhaut, Lionel, Lancelot, Aymeric, Landman, Cecilia, Lanternier, Fanny, Larcheveque, Cecile, Combe, Caroline Lascoux, Lassel, Ludovic, Laverdant, Benjamin, Lavergne, Christophe, Lavillegrand, Jean-Rémi, Lazureanu, Pompilia, Le Guennec, Loïc, Leberre, Lamia, Leblanc, Claire, Leboyer, Marion, Lecomte, Francois, Lecorre, Marine, Leenhardt, Romain, Lefebvre, Marylou, Lefebvre, Bénédicte, Legendre, Paul, Leger, Anne, Legros, Laurence, Legrosse, Justyna, Lehuunghia, Sébastien, Lemarec, Julien, Leporrier-Ext, Jeremie, Lesein, Manon, Lesur, Hubert, Levy, Vincent, Levy, Albert, Lopes, Edwige, Lopes, Amanda, Lopez, Vanessa, Lopinto, Julien, Lortholary, Olivier, Louadah, Badr, Loze, Bénédicte, Lucas, Marie-Laure, Lucasamichi, Axelle, Luong, Liem Binh, Magazimama-Ext, Arouna, Maingret, David, Mameri, Lakhdar, Manivet, Philippe, Mansouri, Cylia, Marcault, Estelle, Marey, Jonathan, Marin, Nathalie, Marois, Clémence, Martin, Olivier, Martineau, Lou, Martinez-Lopez, Cannelle, Martyniuck, Pierre, De Farcy, Pauline Mary, Marzouk, Nessrine, Masmoudi, Rafik, Mebazaa, Alexandre, Mechai, Frédéric, Mecozzi, Fabio, Mediouni, Chamseddine, Megarbane, Bruno, Meghadecha, Mohamed, Mejean, Élodie, Mekinian, Arsene, Abdelhadi, Nour Mekki, Mekni, Rania, Meliti, Thinhinan Sabrina, Lima, Breno Melo, Meng, Paris, Merbah, Soraya, Messani, Fadhila, Messaoudi, Yasmine, Mewasing, Baboo-Irwinsingh, Meziane, Lydia, Michelot-Burger, Carole, Mignot, Françoise, Minka, Fadi Hillary, Miyara, Makoto, Moine, Pierre, Molina, Jean-Michel, Montegnies-Boulet, Anaïs, Monti, Alexandra, Montlahuc, Claire, Montout, Anne-Lise, Moores, Alexandre, Morbieu, Caroline, Mortelette, Helene, Mouly, Stéphane, Muzaffar, Rosita, Nacerddine, Cherifa Iness, Nadal, Marine, Nadif, Hajer, Nassarmadji, Kladoum, Natella, Pierre, Ndingamondze, Sandrine, Neraal, Stefan, Nguyen, Caroline, N'Guyen, Bao, Larmurier, Isabelle Nion, Nlomenyengue, Luc, Noel, Nicolas, Nunes, Hilario, Omar, Edris, Ouazene, Zineb, Ouedraogo, Elise, Ouelaa, Wassila, Oukhedouma, Anissa, Amara, Yasmina Ould, Oya, Herve, Oziel, Johanna, Padilla, Thomas, Paillaud, Elena, Paiva, Solenne, Parfait, Beatrice, Parize, Perrine, Parizot, Christophe, Parrot, Antoine, Pavot, Arthur, Peaudecerf, Laetitia, Pene, Frédéric, Pepin, Marion, Pernet, Julie, Pernin, Claire, Petit, Mylène, Peyrony, Olivier, Pietri, Marie-Pierre, Pietri, Olivia, De Chambrun, Marc Pineton, Pinson, Michelle, Pintado, Claire, Piquard, Valentine, Pires, Christine, Planquette, Benjamin, Poirier, Sandrine, Pomel, Anne-Laure, Pons, Stéphanie, Ponscarme, Diane, Pourcelot, Annegaelle, Pourcher, Valérie, Pouvaret, Anne, Prever, Florian, Previlon, Miresta, Prevost, Margot, Provoost, Marie-Julie, Quemeneur, Cyril, Rafat, Cédric, Rami, Agathe, Ranque, Brigitte, Raphael, Maurice, Raphalen, Jean Herle, Rastoin, Anna, Raux, Mathieu, Rebai, Amani, Reby, Michael, Regent, Alexis, Regrag, Asma, Resche-Rigon, Matthieu, Ressaire, Quentin, Richard, Christian, Richard, Mariecaroline, Robert, Maxence, Rohaut, Benjamin, Rolland-Debord, Camille, Ropers, Jacques, Roque-Afonso, Anne-Marie, Rosso, Charlotte, Rousseaux, Mélanie, Rousseaux, Nabila, Roux, Swasti, Roux, Lorène, Rouzaud, Claire, Rozes, Antoine, Rubenstein, Emma, Sabate, Jean-Marc, Sabet, Sheila, Sacleux, Sophie-Caroline, Kermanach, Nathalie Saidenberg, Saliba, Faouzi, Salmon, Dominique, Savale, Laurent, Savary, Guillaume, Sberro, Rebecca, Scemla, Anne, Schlemmer, Frederic, Schwartz, Mathieu, Sedfi, Saïd, Sefir-Kribel, Samia, Seksik, Philippe, Sellier, Pierre, Selves, Agathe, Sembach, Nicole, Semerano, Luca, Senat, Marie-Victoire, Sene, Damien, Serris, Alexandra, Sese, Lucile, Sghiouar, Naima, Sigaux, Johanna, Siguier, Martin, Silvain, Johanne, Simon, Noémie, Simon, Tabassome, Skandri, Lina Innes, Slimani, Miassa, Snauwaert, Aurélie, Sokol, Harry, Soliman, Heithem, Soltani, Nisrine, Soyer, Benjamin, Steg, Gabriel, Suarez, Lydia, Szwebel, Tali-Anne, Taffame, Kossi, Tandjaoui-Lambiotte, Yacine, Tantet, Claire, Tateo, Mariagrazia, Theodose, Igor, Thiebaud, Pierre clement, Thomas, Caroline, Tiercelet, Kelly, Tisserand, Julie, Tomczak, Carole, Torelino, Krystel, Touam-Ext, Fatima, Toumi, Lilia, Toury, Gustave, Toy-Miou, Mireille, Dinh Thanh Lien, Olivia Tran, Trandinh, Alexy, Treluyer, Jean-Marc, Trinque, Baptiste, Truchot, Jennifer, Tubach, Florence, Tubiana, Sarah, Tunesi, Simone, Turpin, Matthieu, Turpin, Agathe, Urbina, Tomas, Narvaez, Rafael Usubillaga, Uzunhan, Yurdagul, Vaittinadaayar, Prabakar, Valent, Arnaud, Valentian, Maelle, Valin, Nadia, Vallet, Hélène, Vaz, Marina, Vazquezibarra, Miguel-Alejandro, Vedie, Benoit, Velly, Laetitia, Verstuyft, Celine, Viallette, Cedric, Vicaut, Eric, Vignes, Dorothee, Vimpere, Damien, Virlouvet, Myriam, Voiriot, Guillaume, Voisot, Lena, Weiss, Emmanuel, Weiss, Nicolas, Winchenne, Anaïs, Yordanov, Youri, Zafrani, Lara, Zaidan, Mohamad, Zaidi, Wissem, Zak, Cathia, Zarhrate-Ghoul, Aida, Zatout, Ouassila, Zeino, Suzanne, Zeitouni, Michel, Zemirli, Naïma, Zerah, Lorene, Zia, Ounsa, Ziol, Marianne, Zolario, Oceane, Zuber, Julien, Andrejak, Claire, Angoulvant, François, Bachelet, Delphine, Bartoli, Marie, Basmaci, Romain, Behillil, Sylvie, Beluze, Marine, Benkerrou, Dehbia, Bhavsar, Krishna, Bouadma, Lila, Bouchez, Sabelline, Bouscambert, Maude, Cervantes-Gonzalez, Minerva, Chair, Anissa, Chirouze, Catherine, Coelho, Alexandra, Couffin-Cadiergues, Sandrine, d’Ortenzio, Eric, Debray, Marie-Pierre, Deconinck, Laurene, Deplanque, Dominique, Descamps, Diane, Desvallée, Mathilde, Diallo, Alpha, Diouf, Alphonsine, Dorival, Céline, Dubos, François, Elharrar, Brigitte, Enouf, Vincent, Esperou, Hélène, Esposito-Farese, Marina, Etienne, Manuel, Devouge, Eglantine Ferrand, Gault, Nathalie, Gaymard, Alexandre, Ghosn, Jade, Gigante, Tristan, Gilg, Morgane, Guedj, Jérémie, Hoctin, Alexandre, Hoffmann, Isabelle, Houas, Ikram, Hulot, Jean-Sébastien, Jaafoura, Salma, Kaguelidou, Florentia, Kali, Sabrina, Khalil, Antoine, Khan, Coralie, Laouénan, Cédric, Laribi, Samira, Le, Minh, Le Hingrat, Quentin, Le Mestre, Soizic, Le Nagard, Hervé, Lescure, François-Xavier, Letrou, Sophie, Levy, Yves, Lina, Bruno, Lingas, Guillaume, Lucet, Jean-Christophe, Malvy, Denis, Mambert, Marina, Meziane, Amina, Mouquet, Hugo, Mullaert, Jimmy, Neant, Nadège, Nguyen, Duc, Noret, Marion, Nseir, Saad, Papadopoulos, Aurélie, Paul, Christelle, Peiffer-Smadja, Nathan, Perpoint, Thomas, Petrov-Sanchez, Ventzislava, Peytavin, Gilles, Pham, Huong, Picone, Olivier, Puéchal, Oriane, Rabaud, Christian, Rosa-Calatrava, Manuel, Rossignol, Bénédicte, Rossignol, Patrick, Roy, Carine, Schneider, Marion, Su, Richa, Tardivon, Coralie, Tellier, Marie-Capucine, Téoulé, François, Terrier, Olivier, Timsit, Jean-François, Tual, Christelle, Van Der Werf, Sylvie, Vanel, Noémie, Veislinger, Aurélie, Visseaux, Benoit, Wiedemann, Aurélie, Yazdanpanah, Yazdan, Alavoine, Loubna, Burdet, Charles, Charpentier, Charlotte, Dechanet, Aline, Ecobichon, Jean-Luc, Frezouls, Wahiba, Houhou, Nadhira, Lehacaut, Jonathan, Manchon, Pauline, Nouroudine, Mariama, Quintin, Caroline, Thy, Michael, van der Werf, Sylvie, Vignali, Valérie, Chahine, Abir, Waucquier, Nawal, Migaud, Maria-Claire, Djossou, Félix, Mergeay-Fabre, Mayka, Lucarelli, Aude, Demar, Magalie, Bruneau, Léa, Gérardin, Patrick, Maillot, Adrien, Payet, Christine, Laviolle, Bruno, Laine, Fabrice, Paris, Christophe, Desille-Dugast, Mireille, Fouchard, Julie, Pistone, Thierry, Perreau, Pauline, Gissot, Valérie, Goas, Carole L.E., Montagne, Samatha, Richard, Lucie, Bouiller, Kévin, Desmarets, Maxime, Meunier, Alexandre, Bourgeon, Marilou, Lefévre, Benjamin, Jeulin, Hélène, Legrand, Karine, Lomazzi, Sandra, Tardy, Bernard, Gagneux-Brunon, Amandine, Bertholon, Frédérique, Botelho-Nevers, Elisabeth, Kouakam, Christelle, Nicolas, Leturque, Roufai, Layidé, Amat, Karine, Espérou, Hélène, Hendou, Samia, Foti, Giuseppe, Citerio, Giuseppe, Contro, Ernesto, Pesci, Alberto, Valsecchi, Maria Grazia, Cazzaniga, Marina, Bellani, Giacomo, Abad, Jorge, Accordino, Giulia, Angelini, Micol, Aguilera-Albesa, Sergio, Aguiló-Cucurull, Aina, Özkan, Esra Akyüz, Darazam, Ilad Alavi, Roblero Albisures, Jonathan Antonio, Aldave, Juan C., Ramos, Miquel Alfonso, Khan, Taj Ali, Aliberti, Anna, Nadji, Seyed Alireza, Alkan, Gulsum, AlKhater, Suzan A., Allardet-Servent, Jerome, Allende, Luis M., Alonso-Arias, Rebeca, Alshahrani, Mohammed S., Alsina, Laia, Amoura, Zahir, Antolí, Arnau, Arrestier, Romain, Aubart, Mélodie, Auguet, Teresa, Avramenko, Iryna, Aytekin, Gökhan, Azot, Axelle, Bahram, Seiamak, Bajolle, Fanny, Baldanti, Fausto, Baldolli, Aurélie, Ballester, Maite, Barrou, Benoit, Barzaghi, Federica, Basso, Sabrina, Bayhan, Gulsum Iclal, Bezrodnik, Liliana, Bilbao, Agurtzane, Blanchard-Rohner, Geraldine, Blanco, Ignacio, Blandinières, Adeline, Blázquez-Gamero, Daniel, Bloomfield, Marketa, Bolivar-Prados, Mireia, Borie, Raphael, Botdhlo-Nevers, Elisabeth, Bousquet, Aurore, Boutolleau, David, Bouvattier, Claire, Boyarchuk, Oksana, Bravais, Juliette, Briones, M. Luisa, Brunner, Marie-Eve, Bruno, Raffaele, Bueno, Maria Rita P., Bukhari, Huda, Bustamante, Jacinta, Cáceres Agra, Juan José, Capra, Ruggero, Carapito, Raphael, Carrabba, Maria, Casasnovas, Carlos, Caseris, Marion, Cassaniti, Irene, Castelle, Martin, Castelli, Francesco, Castillo de Vera, Martín, Castro, Mateus V., Catherinot, Emilie, Celik, Jale Bengi, Ceschi, Alessandro, Chalumeau, Martin, Charbit, Bruno, Boulanger, Cécile, Clavé, Père, Clotet, Bonaventura, Codina, Anna, Comarmond, Cloé, Comoli, Patrizia, Corsico, Angelo G., Coşkuner, Taner, Cvetkovski, Aleksandar, Cyrus, Cyril, Dalmau, David, Danion, François, Darley, David Ross, Das, Vincent, Dauby, Nicolas, Dauger, Stéphane, De Munte, Paul, de Pontual, Loic, Dehban, Amin, Delplancq, Geoffroy, Desguerre, Isabelle, Di Sabatino, Antonio, Diehl, Jean-Luc, Dobbelaere, Stephanie, Domínguez-Garrido, Elena, Dubost, Clément, Ekwall, Olov, Bozdemir, Şefika Elmas, Elnagdy, Marwa H., Emiroglu, Melike, Endo, Akifumi, Erdeniz, Emine Hafize, Aytekin, Selma Erol, Etxart Lasa, Maria Pilar, Euvrard, Romain, Fabio, Giovanna, Faivre, Laurence, Falck, Antonin, Fartoukh, Muriel, Faure, Morgane, Arquero, Miguel Fernandez, Ferrer, Ricard, Ferreres, Jose, Francois, Bruno, Fumadó, Victoria, Fung, Kitty S.C., Fusco, Francesca, Gagro, Alenka, Solis, Blanca Garcia, Garçon, Pierre, Gaussem, Pascale, Gayretli, Zeynep, Gil-Herrera, Juana, Gilardin, Laurent, Gatineau, Audrey Giraud, Girona-Alarcón, Mònica, Cifuentes Godínez, Karen Alejandra, Goffard, Jean-Christophe, Gonzales, Nacho, Gonzalez-Granado, Luis I., González-Montelongo, Rafaela, Guerder, Antoine, Gülhan, Belgin, Gumucio, Victor Daniel, Hanitsch, Leif Gunnar, Gunst, Jan, Gut, Marta, Hadjadj, Jérôme, Hancerli, Selda, Hariyan, Tetyana, Hatipoglu, Nevin, Heppekcan, Deniz, Hernandez-Brito, Elisa, Ho, Po-ki, Holanda-Peña, María Soledad, Horcajada, Juan P., Hraiech, Sami, Humbert, Linda, Hung, Ivan F.N., Iglesias, Alejandro D., Íñigo-Campos, Antonio, Jamme, Matthieu, Arranz, María Jesús, Jimeno, Marie-Thérèse, Jordan, Iolanda, Kanık-Yüksek, Saliha, Kara, Yalcin, Karahan, Aydın, Karbuz, Adem, Yasar, Kadriye Kart, Kasapcopur, Ozgur, Kashimada, Kenichi, Keles, Sevgi, Demirkol, Yasemin Kendir, Kido, Yasutoshi, Kizil, Can, Kılıç, Ahmet Osman, Klocperk, Adam, Koutsoukou, Antonia, Król, Zbigniew J., Ksouri, Hatem, Kuentz, Paul, Kwan, Arthur M.C., Kwan, Yat Wah M., Kwok, Janette S.Y., Lagier, Jean-Christophe, Lam, David S.Y., Lampropoulou, Vicky, Le Bourgeois, Fleur, Leo, Yee-Sin, Lopez, Rafael Leon, Leung, Daniel, Levin, Michael, Levy, Michael, Lévy, Romain, Li, Zhi, Lilleri, Daniele, Adrian Bolanos Lima, Edson Jose, Linglart, Agnes, López-Collazo, Eduardo, Lorenzo-Salazar, José M., Louapre, Céline, Lubetzki, Catherine, Lung, Kwok-Cheung, Luyt, Charles-Edouard, Lye, David C., Magnone, Cinthia, Marchioni, Enrico, Marioli, Carola, Marjani, Majid, Marques, Laura, Pereira, Jesus Marquez, Martín-Nalda, Andrea, Pueyo, David Martínez, Martinez-Picado, Javier, Marzana, Iciar, Mata-Martínez, Carmen, Mathian, Alexis, Matos, Larissa R.B., Matthews, Gail V., Mayaux, Julien, McLaughlin-Garcia, Raquel, Meersseman, Philippe, Mège, Jean-Louis, Mekontso-Dessap, Armand, Melki, Isabelle, Meloni, Federica, Meritet, Jean-François, Merlani, Paolo, Akcan, Özge Metin, Mezidi, Mehdi, Migeotte, Isabelle, Millereux, Maude, Million, Matthieu, Mirault, Tristan, Mircher, Clotilde, Mirsaeidi, Mehdi, Mizoguchi, Yoko, Modi, Bhavi P., Mojoli, Francesco, Moncomble, Elsa, Melián, Abián Montesdeoca, Martinez, Antonio Morales, Morandeira, Francisco, Morange, Pierre-Emmanuel, Mordacq, Clémence, Morelle, Guillaume, Mouly, Stéphane J., Muñoz-Barrera, Adrián, Nafati, Cyril, Nagashima, Shintaro, Nakagama, Yu, Neven, Bénédicte, Neves, João Farela, Ng, Yuk-Yung, Hubert Nielly, Medina, Yeray Novoa, Cuadros, Esmeralda Nuñez, Karabela, Semsi Nur, Ocejo-Vinyals, J. Gonzalo, Oualha, Mehdi, Ouedrani, Amani, Özçelik, Tayfun, Ozkaya-Parlakay, Aslinur, Pagani, Michele, Papadaki, Maria, Parola, Philippe, Pascreau, Tiffany, Paul, Stéphane, Paz-Artal, Estela, Pedraza, Sigifredo, González Pellecer, Nancy Carolina, Pellegrini, Silvia, Pérez de Diego, Rebeca, Pérez-Fernández, Xosé Luis, Philippe, Aurélien, Philippot, Quentin, Picod, Adrien, Pineton de Chambrun, Marc, Piralla, Antonio, Planas-Serra, Laura, Ploin, Dominique, Poissy, Julien, Poncelet, Géraldine, Poulakou, Garyphallia, Pouletty, Marie S., Pourshahnazari, Persia, Qiu-Chen, Jia Li, Quentric, Paul, Rambaud, Thomas, Raoult, Didier, Raoult, Violette, Rebillat, Anne-Sophie, Redin, Claire, Resmini, Léa, Ricart, Pilar, Richard, Jean-Christophe, Rigo-Bonnin, Raúl, Rivet, Nadia, Rivière, Jacques G., Rocamora-Blanch, Gemma, Rodero, Mathieu P., Rodrigo, Carlos, Rodriguez, Luis Antonio, Rodriguez-Gallego, Carlos, Rodriguez-Palmero, Agustí, Romero, Carolina Soledad, Rothenbuhler, Anya, Roux, Damien, Rovina, Nikoletta, Rozenberg, Flore, Ruch, Yvon, Ruiz, Montse, Ruiz del Prado, Maria Yolanda, Ruiz-Rodriguez, Juan Carlos, Sabater-Riera, Joan, Saks, Kai, Salagianni, Maria, Sanchez, Oliver, Sánchez-Montalvá, Adrián, Sánchez-Ramón, Silvia, Schidlowski, Laire, Schluter, Agatha, Schmidt, Julien, Schmidt, Matthieu, Schuetz, Catharina, Schweitzer, Cyril E., Scolari, Francesco, Seijo, Luis, Seminario, Analia Gisela, Seng, Piseth, Senoglu, Sevtap, Seppänen, Mikko, Llovich, Alex Serra, Siguret, Virginie, Siouti, Eleni, Smadja, David M., Smith, Nikaia, Sobh, Ali, Solanich, Xavier, Solé-Violán, Jordi, Soler, Catherine, Sözeri, Betül, Stella, Giulia Maria, Stepanovskiy, Yuriy, Stoclin, Annabelle, Taccone, Fabio, Taupin, Jean-Luc, Tavernier, Simon J., Tello, Loreto Vidaur, Terrier, Benjamin, Thiery, Guillaume, Thorn, Karolina, Thumerelle, Caroline, Tipu, Imran, Tolstrup, Martin, Tomasoni, Gabriele, Toubiana, Julie, Alvarez, Josep Trenado, Triantafyllia, Vasiliki, Troya, Jesús, Tsang, Owen T.Y., Tserel, Liina, Tso, Eugene Y.K., Tucci, Alessandra, Tüter Öz, Şadiye Kübra, Ursini, Matilde Valeria, Utsumi, Takanori, Vabres, Pierre, Valencia-Ramos, Juan, Van Den Rym, Ana Maria, Vandernoot, Isabelle, Velez-Santamaria, Valentina, Zuniga Veliz, Silvia Patricia, Vidigal, Mateus C., Viel, Sébastien, Villain, Cédric, Vilaire-Meunier, Marie E., Villar-García, Judit, Vincent, Audrey, Van der Linden, Dimitri, Volokha, Alla, Vuotto, Fanny, Wauters, Els, Wu, Alan K.L., Wu, Tak-Chiu, Yahşi, Aysun, Yesilbas, Osman, Yildiz, Mehmet, Young, Barnaby E., Yükselmiş, Ufuk, Zecca, Marco, Zuccaro, Valentina, Van Praet, Jens, Lambrecht, Bart N., Van Braeckel, Eva, Bosteels, Cédric, Hoste, Levi, Hoste, Eric, Bauters, Fré, De Clercq, Jozefien, Heijmans, Catherine, Slabbynck, Hans, Naesens, Leslie, Florkin, Benoit, Young, Mary-Anne, Willis, Amanda, Lapuente-Suanzes, Paloma, de Andrés-Martín, Ana, Berkell, Matilda, Carelli, Valerio, Fiorentino, Alessia, Malhotra, Surbhi, Mattiaccio, Alessandro, Pippucci, Tommaso, Seri, Marco, Tacconelli, Evelina, van Agtmael, Michiel, Algera, Anne Geke, Appelman, Brent, van Baarle, Frank, Bax, Diane, Beudel, Martijn, Bogaard, Harm Jan, Bomers, Marije, Bonta, Peter, Bos, Lieuwe, Botta, Michela, de Brabander, Justin, de Bree, Godelieve, de Bruin, Sanne, Buis, David T.P., Bugiani, Marianna, Bulle, Esther, Chouchane, Osoul, Cloherty, Alex, Dijkstra, Mirjam, Dongelmans, Dave A., Dujardin, Romein W.G., Elbers, Paul, Fleuren, Lucas, Geerlings, Suzanne, Geijtenbeek, Theo, Girbes, Armand, Goorhuis, Bram, Grobusch, Martin P., Hafkamp, Florianne, Hagens, Laura, Hamann, Jorg, Harris, Vanessa, Hemke, Robert, Hermans, Sabine M., Heunks, Leo, Hollmann, Markus, Horn, Janneke, Hovius, Joppe W., de Jong, Menno D., Koning, Rutger, Lim, Endry H.T., van Mourik, Niels, Nellen, Jeaninne, Nossent, Esther J., Paulus, Frederique, Peters, Edgar, Pina-Fuentes, Dan A.I., van der Poll, Tom, Preckel, Bennedikt, Prins, Jan M., Raasveld, Jorinde, Reijnders, Tom, de Rotte, Maurits C.F. J., Schinkel, Michiel, Schultz, Marcus J., Schrauwen, Femke A.P., Schuurmans, Alex, Schuurmans, Jaap, Sigaloff, Kim, Slim, Marleen A., Smeele, Patrick, Smit, Marry, Stijnis, Cornelis S., Stilma, Willemke, Teunissen, Charlotte, Thoral, Patrick, Tsonas, Anissa M., Tuinman, Pieter R., van der Valk, Marc, Veelo, Denise P., Volleman, Carolien, de Vries, Heder, Vught, Lonneke A., van Vugt, Michèle, Wouters, Dorien, Zwinderman, A.H., Brouwer, Matthijs C., Wiersinga, W. Joost, Vlaar, Alexander P.J., Tompkins, Miranda F., Alba, Camille, Hupalo, Daniel N., Rosenberger, John, Sukumar, Gauthaman, Wilkerson, Matthew D., Zhang, Xijun, Lack, Justin, Oler, Andrew J., Dobbs, Kerry, Delmonte, Ottavia M., Danielson, Jeffrey J., Biondi, Andrea, Bettini, Laura Rachele, D’Angiò, Mariella, Beretta, Ilaria, Imberti, Luisa, Sottini, Alessandra, Quaresima, Virginia, Quiros-Roldan, Eugenia, Rossi, Camillo, Castagnoli, Riccardo, Montagna, Daniela, Licari, Amelia, Marseglia, Gian Luigi, Marchal, Astrid, Cirulli, Elizabeth T., Neveux, Iva, Bellos, Evangelos, Thwaites, Ryan S., Schiabor Barrett, Kelly M., Zhang, Yu, Nemes-Bokun, Ivana, Kalinova, Mariya, Catchpole, Andrew, Lack, Justin B., Chiu, Christopher, and Grzymski, Joseph J.

Published
2024
Full Text
View/download PDF

7. Biomarker Analysis Provides Evidence for Host Response Homogeneity in Patients With COVID-19

Author

van Agtmael, Michiel A., Algera, Anne G., Appelman, Brent, van Baarle, Floor E.H.P., van de Beek, Diederik, Beudel, Martijn, Bogaard, Harm J., Bos, Lieuwe D.J., Botta, Michela, de Brabander, Justin, de Bree, Godelieve J., Brouwer, Matthijs C., de Bruin, Sanne, Bugiani, Marianna, Bulle, Esther B., Chouchane, Osoul, Cloherty, Alex P.M., Buis, David, de Rotte, Maurtis C.F.J., Dijkstra, Mirjam, Dongelmans, Dave A., Dujardin, Romein W.G., Elbers, Paul E., Fleuren, Lucas M., Geerlings, Suzanne E., Geijtenbeek, Theo B.H., Girbes, Armand R.J., Goorhuis, Bram, Grobusch, Martin P., Hagens, Laura A., Hamann, Jorg, Harris, Vanessa C., Hemke, Robert, Hermans, Sabine M., Heunks, Leo M.A., Hollmann, Markus W., Horn, Janneke, Hovius, Joppe W., de Jong, Menno D., Koning, Rutger, Lim, Endry H.T., van Mourik, Niels, Nellen, Jeannine F., Nossent, Esther J., Paulus, Frederique, Peters, Edgar, Piña-Fuentes, Dan, van der Poll, Tom, Preckel, Bennedikt, Raasveld, Jorinde, Reijnders, Tom D.Y., Schinkel, Michiel, Schrauwen, Femke A.P., Schultz, Marcus J., Schuurman, Alex R., Schuurmans, Jaap, Sigaloff, Kim, Slim, Marleen A., Smeele, Patrick, Smit, Marry R., Stijnis, Cornelis, Stilma, Willemke, Teunissen, Charlotte E., Thoral, Patrick, Tsonas, Anissa M., Tuinman, Pieter R., van der Valk, Marc, Veelo, Denise P., Vlaar, Alexander P.J., Volleman, Carolien, de Vries, Heder, van Vught, Lonneke A., van Vugt, Michèle, Wiersinga, Joost, Wouters, Dorien, Zwinderman, Koos, van Amstel, Rombout B.E., Michels, Erik H.A., and Smeele, Patrick J.

Published
2024
Full Text
View/download PDF

9. Platelets of COVID-19 patients display mitochondrial dysfunction, oxidative stress, and energy metabolism failure compatible with cell death

Author

Agtmael, Michiel van, Algera, Anne Geke, Appelman, Brent, van Baarle, Floor, Beudel, Martijn, Bogaard, Harm Jan, Bomers, Marije, Bonta, Peter, Bos, Lieuwe, Botta, Michela, de Brabander, Justin, de Bree, Godelieve, de Bruin, Sanne, Bugiani, Marianna, Bulle, Esther, Buis, David T.P., Chouchane, Osoul, Clohert, Alex, Dijkstra, Mirjam, Dongelmans, Dave A., Dujardin, Romein W.G., Elbers, Paul, Fleuren, Lucas, Geerlings, Suzanne, Geijtenbeek, Theo, Girbes, Armand, Goorhuis, Bram, Grobusch, Martin P., Hagens, Laura, Hamann, Jorg, Harris, Vanessa, Hemke, Robert, Hermans, Sabine M., Heunks, Leo, Hollmann, Markus, Horn, Janneke, Hovius, Joppe W., de Jong, Menno D., Koning, Rutger, Lim, Endry H.T., van Mourik, Niels, Nellen, Jeaninne, Nossent, Esther J., Olie, Sabine, Paulus, Frederique, Peters, Edgar, Pina-Fuentes, Dan A.I., van der Poll, Tom, Preckel, Bennedikt, Raasveld, Jorinde, Reijnders, Tom, de Rotte, Maurits C.F.J., Schinkel, Michiel, Schultz, Marcus J., Schrauwen, Femke A.P., Schuurman, Alex, Schuurmans, Jaap, Sigaloff, Kim, Slim, Marleen A., Smeele, Patrick, Smit, Marry, Stijnis, Cornelis S., Stilma, Willemke, Teunissen, Charlotte, Thoral, Patrick, Tsonas, Anissa M., Tuinman, Pieter R., van der Valk, Marc, Veelo, Denise, Volleman, Carolien, de Vries, Heder, Vught, Lonneke A., van Vugt, Michèle, Wouters, Dorien, Zwinderman, A.H., Brouwer, Matthijs C., Wiersinga, W. Joost, Vlaar, Alexander P.J., van de Beek, Diederik, Léopold, Valentine, Butler, Joe M., Schuurman, Alex R., Michels, Erik H.A., Schomakers, Bauke V., van Weeghel, Michel, Picavet-Havik, Daisy I., Grootemaat, Anita E., Douma, Renée A., Reijnders, Tom D.Y., Klarenbeek, Augustijn M., van der Wel, Nicole N., den Dunnen, Jeroen, Houtkooper, Riekelt H., and van't Veer, Cornelis

Published
2023
Full Text
View/download PDF

10. Comparative analysis of spike-specific IgG Fc glycoprofiles elicited by adenoviral, mRNA, and protein-based SARS-CoV-2 vaccines

Author

Appelman, Brent, van de Beek, Diederik, Bomers, Marije K., de Brabander, Justin, Brouwer, Matthijs C., Buis, David T.P., Chekrouni, Nora, van Gils, Marit J., de Jong, Menno D., Lavell, Ayesha H.A., van Mourik, Niels, Olie, Sabine E., Peters, Edgar J.G., Reijnders, Tom D.Y., Schinkel, Michiel, Schuurman, Alex R., Sikkens, Jonne J., Slim, Marleen A., Smulders, Yvo M., Vlaar, Alexander P.J., van Vught, Lonneke A., Wiersinga, Joost W., Spinello, Antinori, Bassoli, Cinzia, Bestetti, Giovanna, Corbellino, Mario, Covizzi, Alice, Lupo, Angelica, Milazzo, Laura, Schiuma, Marco, Torre, Alessandro, de Jongh, Willem A., Salanti, Ali, Theander, Thor G., McCall, Matthew B.B., Esen, Meral, Van Coillie, Julie, Pongracz, Tamas, Šuštić, Tonći, Wang, Wenjun, Nouta, Jan, Le Gars, Mathieu, Keijzer, Sofie, Linty, Federica, Cristianawati, Olvi, Keijser, Jim B.D., Visser, Remco, Smit, Merel J., Sander, Adam, Schmidt, David E., Steenhuis, Maurice, Rispens, Theo, Nielsen, Morten A., Mordmüller, Benjamin G., Ellen van der Schoot, C., Roozendaal, Ramon, Wuhrer, Manfred, and Vidarsson, Gestur

Published
2023
Full Text
View/download PDF

11. Viral, Bacterial, Metabolic, and Autoimmune Causes of Severe Acute Encephalopathy in Sub-Saharan Africa: A Multicenter Cohort Study

Author

Edridge, Arthur, Namazzi, Ruth, Tebulo, Andrew, Mfizi, Anan, Deijs, Martin, Koekkoek, Sylvie, de Wever, Bob, van der Ende, Arie, Umiwana, Jeanine, de Jong, Menno D., Jans, Judith, Verhoeven-Duif, Nanda, Titulaer, Maarten, van Karnebeek, Clara, Seydel, Karl, Taylor, Terrie, Asiimwe-Kateera, Brenda, van der Hoek, Lia, Kabayiza, Jean-Claude, Mallewa, Macpherson, Idro, Richard, Boele van Hensbroek, Michael, and van Woensel, Job B.M.

Published
2023
Full Text
View/download PDF

13. The BNT162b2 mRNA SARS-CoV-2 vaccine induces transient afucosylated IgG1 in naive but not in antigen-experienced vaccinees

Author

Antinori, Spinello, Bassoli, Cinzia, Bestetti, Giovanna, Corbellino, Mario, Covizzi, Alice, Lupo, Angelica, Milazzo, Laura, Schiuma, Marco, Torre, Alessandro, Appelman, Brent, van de Beek, Diederik, Bomers, Marije K., de Brabander, Justin, Brouwer, Matthijs C., Buis, David T.P., Chekrouni, Nora, van Gils, Marit J., de Jong, Menno D., Lavell, Ayesha H.A., van Mourik, Niels, Olie, Sabine E., Peters, Edgar J.G., Reijnders, Tom D.Y., Schinkel, Michiel, Schuurman, Alex R., Sikkens, Jonne J., Slim, Marleen A., Smulders, Yvo M., Vlaar, Alexander P.J., van Vught, Lonneke A., Wiersinga, Joost W., Van Coillie, Julie, Pongracz, Tamas, Rahmöller, Johann, Chen, Hung-Jen, Geyer, Chiara Elisabeth, Buhre, Jana Sophia, Šuštić, Tonći, van Osch, Thijs Luc Junior, Steenhuis, Maurice, Hoepel, Willianne, Wang, Wenjun, Lixenfeld, Anne Sophie, Nouta, Jan, Keijzer, Sofie, Linty, Federica, Visser, Remco, Larsen, Mads Delbo, Martin, Emily Lara, Künsting, Inga, Lehrian, Selina, von Kopylow, Vera, Kern, Carsten, Lunding, Hanna Bele, de Winther, Menno, Rispens, Theo, Graf, Tobias, Slim, Marleen Adriana, Minnaar, René Peter, Bomers, Marije Kristianne, Sikkens, Jonne Jochum, van der Schoot, C. Ellen, den Dunnen, Jeroen, Wuhrer, Manfred, Ehlers, Marc, and Vidarsson, Gestur

Published
2023
Full Text
View/download PDF

14. Recent infection with HCoV-OC43 may be associated with protection against SARS-CoV-2 infection

Author

Lavell, A.H. Ayesha, Sikkens, Jonne J., Edridge, Arthur W.D., van der Straten, Karlijn, Sechan, Ferdyansyah, Oomen, Melissa, Buis, David T.P., Schinkel, Michiel, Burger, Judith A., Poniman, Meliawati, van Rijswijk, Jacqueline, de Jong, Menno D., de Bree, Godelieve J., Peters, Edgar J.G., Smulders, Yvo M., Sanders, Rogier W., van Gils, Marit J., van der Hoek, Lia, and Bomers, Marije K.

Published
2022
Full Text
View/download PDF

15. Epidemiologic and Genomic Analysis of SARS-CoV-2 Delta Variant Superspreading Event in Nightclub, the Netherlands, June 2021

Author

Koopsen, Jelle, van Ewijk, Oatharina E., Bavalia, Roisin, Cornelissen, Akke, Bruisten, Sylvia M., de Gee, Floor, Han, Alvin X., de Jong, Maarten, de Jong, Menno D., Jonges, Marcel, Khawaja, Norin, Koene, Fleur M.H.P.A., van der Lubben, Mariken, Mikulic, Iris, Rebers, Sjoerd P.H., Russell, Colin A., Schinkel, Janke, Schrejer, Anja J.M., Uil, Judith A. den, Welkers, Matthijs R.A., and Leenstra, Tjalling

Subjects
Epidemics -- Risk factors -- Causes of -- Netherlands, Nightclubs -- Health aspects, Disease transmission -- Risk factors -- Causes of, Company distribution practices, Health
Abstract

Because of decreasing severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) incidence rates in the Netherlands at the time, the government of the Netherlands lifted most restrictions on June 26, [...]

Published
2022
Full Text
View/download PDF

16. Sensemaking in Supervisor-Doctoral Student Relationships: Revealing Schemas on the Fulfillment of Basic Psychological Needs

Author

Janssen, Suzanne, van Vuuren, Mark, and de Jong, Menno D. T.

Abstract

Mentoring relationships between research supervisors and doctoral students play a key role in doctoral students' success. Self-determination theory assumes that the quality of these relationships can be defined in terms of fulfillment of students' basic psychological needs for autonomy, competence, and relatedness. Studies on how supervisors and students build need-supportive relationships are, however, lacking. Taking a schema-based perspective, this article investigates supervisors' and doctoral students' (mis)alignments in schemas on how to fulfill students' basic needs in their relationship. Qualitative data were obtained from a sample of 18 interviews (nine dyads) to reveal the schema-driven sensemaking of students and their supervisors. Findings show that the idea of schema similarity might be too simple: For each of the three basic needs, tensions arise between students' and supervisors' schemas. These need-based schemas in action offer a fresh perspective for understanding why some supervisor-doctoral student relationships are experienced as successful while others are not.

Published
2021
Full Text
View/download PDF

18. Science communication under pressure: perspectives of Dutch researchers and journalists on COVID-19 communication challenges.

Author

de Jong, Anouk, Dijkstra, Anne M., MacLeod, Miles A. J., and de Jong, Menno D. T.

Subjects
CITIZENS, SCIENCE journalism, RESEARCH personnel, SCIENTIFIC communication, COVID-19 pandemic
Abstract

Introduction: Having access to information about science is essential for citizens to relate to global challenges. The COVID-19 pandemic is a clear example of how citizens' dependency on scientific information increased. This study aimed to gain an understanding of the challenges researchers and journalists encountered in communicating about COVID-19 and included an analysis of their roles and responsibilities in science-media interactions. Method: Semi-structured interviews were conducted with experienced journalists (n = 10) and prominent academic researchers in fields relevant to COVID-19 (n = 11) in the Netherlands. Results: Results show that the pandemic highlighted several challenges in science-media interactions. The pandemic's complexity, uncertainty, and large societal impact put pressure on researchers and journalists who dealt with the societal need for relevant information and combatting misinformation. In response to the challenges they encountered, researchers and journalists had frequent and ongoing interactions with each other. For researchers, this raised the issue of how to balance their responsibilities to inform and advise as public experts. For journalists, this highlighted the need to avoid reporter-source intimacy and remain independent and critical when reporting about science. Conclusion: These findings raise new issues on the roles and responsibilities of researchers and journalists in urgent, fast-moving contexts such as those experienced during the pandemic and other global challenges. Successful responses to challenges such as dealing with misinformation and pre-prints require further reflection on the roles and responsibilities of both actors. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

19. A single mRNA vaccine dose in COVID-19 patients boosts neutralizing antibodies against SARS-CoV-2 and variants of concern

Author

Agard, Ivette, Ayal, Jane, Boyd, Anders, Cavdar, Floor, Craanen, Marianne, Davidovich, Udi, Deuring, Annemarieke, van Dijk, Annelies, Ersan, Ertan, del Grande, Laura, Hartman, Joost, Koedoot, Nelleke, Leenstra, Tjalling, Loomans, Dominique, Makowska, Agata, du Maine, Tom, de Man, Ilja, Matser, Amy, van der Meij, Lizenka, van Polanen, Marleen, Oud, Maria, Reid, Clark, Storey, Leeann, de Wit, Marije, van Wijk, Marc, van Assem, Joyce, van den Aardweg, Joost, van Beek, Marijne, Blankert, Thyra, Boeser-Nunnink, Brigitte, Moll van Charante, Eric, van Dort, Karel, Figaroa, Orlane, Frenkel, Leah, Girigorie, Arginell, van Haga, Jelle, Harskamp-Holwerda, Agnes, Hazenberg, Mette, Hidad, Soemeja, de Jong, Nina, Jonges, Marcel, Jurriaans, Suzanne, Knoop, Hans, Kuijt, Lara, Lok, Anja, Ruiz, Marga Mangas, Maurer, Irma, Nieuwkerk, Pythia, van Nuenen, Ad, van der Veen, Annelou, Verkaik, Bas, Visser, Gerben-Rienk, van Gils, Marit J., van Willigen, Hugo D.G., Wynberg, Elke, Han, Alvin X., van der Straten, Karlijn, Burger, Judith A., Poniman, Meliawati, Oomen, Melissa, Tejjani, Khadija, Bouhuijs, Joey H., Verveen, Anouk, Lebbink, Romy, Dijkstra, Maartje, Appelman, Brent, Lavell, A.H. Ayesha, Caniels, Tom G., Bontjer, Ilja, van Vught, Lonneke A., Vlaar, Alexander P.J., Sikkens, Jonne J., Bomers, Marije K., Russell, Colin A., Kootstra, Neeltje A., Sanders, Rogier W., Prins, Maria, de Bree, Godelieve J., and de Jong, Menno D.

Published
2022
Full Text
View/download PDF

23. Head-to-head validation of six immunoassays for SARS-CoV-2 in hospitalized patients

Author

van Agtmael, M., Algera, A.G., van Baarle, F., Bax, D., Beudel, M., Bogaard, H.J., Bomers, M., Bos, L., Botta, M., de Brabander, J., Brouwer, M.C., de Bruin, S., Bugiani, M., Bulle, E., Chouchane, O., Cloherty, A., Elbers, P., Fleuren, L., Geerlings, S., Geerts, B., Geijtenbeek, T., Girbes, A., Goorhuis, A., Grobusch, M.P., Hafkamp, F., Hagens, L., Hamann, J., Harris, V., Hemke, R., Hermans, S.M., Heunks, L., Hollmann, M.W., Horn, J., Hovius, J.W., Koning, R., van Mourik, N., Nellen, J., Paulus, F., Peters, E., van der Poll, T., Preckel, B., Prins, J.M., Raasveld, J., Reijnders, T., Schinkel, M., Schultz, M.J., Schuurman, A., Sigaloff, K., Smit, M., Stijnis, C.S., Stilma, W., Thoral, P., Tsonas, A., van der Valk, M., Veelo, D., Vlaar, A.P.J., de Vries, H., Wiersinga, W.J., Wouters, D., Zwinderman, A.H., van de Beek, D., Zonneveld, Rens, Jurriaans, Suzanne, van Gool, Tom, Hofstra, Jorrit J., Hekker, Thecla A.M., Defoer, Pien, Broekhuizen-van Haaften, Patricia E., Wentink-Bonnema, Ellen M., Boonkamp, Lynn, Teunissen, Charlotte E., Heijboer, Annemieke C., Martens, Frans, de Bree, Godelieve, van Vugt, Michele, van Houdt, Robin, Schinkel, Janke, and de Jong, Menno D.

Published
2021
Full Text
View/download PDF

24. Long-term evolution of human seasonal influenza virus A(H3N2) is associated with an increase in polymerase complex activity

Author

Vigeveno, René M, Han, Alvin X, de Vries, Robert P, Parker, Edyth, de Haan, Karen, van Leeuwen, Sarah, Hulme, Katina D, Lauring, Adam S, Te Velthuis, Aartjan J W, Boons, Geert-Jan, Fouchier, Ron A M, Russell, Colin A, de Jong, Menno D, Eggink, Dirk, Vigeveno, René M, Han, Alvin X, de Vries, Robert P, Parker, Edyth, de Haan, Karen, van Leeuwen, Sarah, Hulme, Katina D, Lauring, Adam S, Te Velthuis, Aartjan J W, Boons, Geert-Jan, Fouchier, Ron A M, Russell, Colin A, de Jong, Menno D, and Eggink, Dirk

Abstract

Since the influenza pandemic in 1968, influenza A(H3N2) viruses have become endemic. In this state, H3N2 viruses continuously evolve to overcome immune pressure as a result of prior infection or vaccination, as is evident from the accumulation of mutations in the surface glycoproteins hemagglutinin (HA) and neuraminidase (NA). However, phylogenetic studies have also demonstrated ongoing evolution in the influenza A(H3N2) virus RNA polymerase complex genes. The RNA polymerase complex of seasonal influenza A(H3N2) viruses produces mRNA for viral protein synthesis and replicates the negative sense viral RNA genome (vRNA) through a positive sense complementary RNA intermediate (cRNA). Presently, the consequences and selection pressures driving the evolution of the polymerase complex remain largely unknown. Here, we characterize the RNA polymerase complex of seasonal influenza A(H3N2) viruses representative of nearly 50 years of influenza A(H3N2) virus evolution. The H3N2 polymerase complex is a reassortment of human and avian influenza virus genes. We show that since 1968, influenza A(H3N2) viruses have increased the transcriptional activity of the polymerase complex while retaining a close balance between mRNA, vRNA, and cRNA levels. Interestingly, the increased polymerase complex activity did not result in increased replicative ability on differentiated human airway epithelial (HAE) cells. We hypothesize that the evolutionary increase in polymerase complex activity of influenza A(H3N2) viruses may compensate for the reduced HA receptor binding and avidity that is the result of the antigenic evolution of influenza A(H3N2) viruses.

Published
2024

25. Determinants of epidemic size and the impacts of lulls in seasonal influenza virus circulation

Author

de Jong, Simon P.J., Felix Garza, Zandra C., Gibson, Joseph C., van Leeuwen, Sarah, de Vries, Robert P., Boons, Geert Jan, van Hoesel, Marliek, de Haan, Karen, van Groeningen, Laura E., Hulme, Katina D., van Willigen, Hugo D.G., Wynberg, Elke, de Bree, Godelieve J., Matser, Amy, Bakker, Margreet, van der Hoek, Lia, Prins, Maria, Kootstra, Neeltje A., Eggink, Dirk, Nichols, Brooke E., Han, Alvin X., de Jong, Menno D., Russell, Colin A., de Jong, Simon P.J., Felix Garza, Zandra C., Gibson, Joseph C., van Leeuwen, Sarah, de Vries, Robert P., Boons, Geert Jan, van Hoesel, Marliek, de Haan, Karen, van Groeningen, Laura E., Hulme, Katina D., van Willigen, Hugo D.G., Wynberg, Elke, de Bree, Godelieve J., Matser, Amy, Bakker, Margreet, van der Hoek, Lia, Prins, Maria, Kootstra, Neeltje A., Eggink, Dirk, Nichols, Brooke E., Han, Alvin X., de Jong, Menno D., and Russell, Colin A.

Abstract

During the COVID-19 pandemic, levels of seasonal influenza virus circulation were unprecedentedly low, leading to concerns that a lack of exposure to influenza viruses, combined with waning antibody titres, could result in larger and/or more severe post-pandemic seasonal influenza epidemics. However, in most countries the first post-pandemic influenza season was not unusually large and/or severe. Here, based on an analysis of historical influenza virus epidemic patterns from 2002 to 2019, we show that historic lulls in influenza virus circulation had relatively minor impacts on subsequent epidemic size and that epidemic size was more substantially impacted by season-specific effects unrelated to the magnitude of circulation in prior seasons. From measurements of antibody levels from serum samples collected each year from 2017 to 2021, we show that the rate of waning of antibody titres against influenza virus during the pandemic was smaller than assumed in predictive models. Taken together, these results partially explain why the re-emergence of seasonal influenza virus epidemics was less dramatic than anticipated and suggest that influenza virus epidemic dynamics are not currently amenable to multi-season prediction.

Published
2024

26. Long-term evolution of human seasonal influenza virus A(H3N2) is associated with an increase in polymerase complex activity

Author

Afd Chemical Biology and Drug Discovery, Sub Chemical Biology and Drug Discovery, Chemical Biology and Drug Discovery, Vigeveno, René M, Han, Alvin X, de Vries, Robert P, Parker, Edyth, de Haan, Karen, van Leeuwen, Sarah, Hulme, Katina D, Lauring, Adam S, Te Velthuis, Aartjan J W, Boons, Geert-Jan, Fouchier, Ron A M, Russell, Colin A, de Jong, Menno D, Eggink, Dirk, Afd Chemical Biology and Drug Discovery, Sub Chemical Biology and Drug Discovery, Chemical Biology and Drug Discovery, Vigeveno, René M, Han, Alvin X, de Vries, Robert P, Parker, Edyth, de Haan, Karen, van Leeuwen, Sarah, Hulme, Katina D, Lauring, Adam S, Te Velthuis, Aartjan J W, Boons, Geert-Jan, Fouchier, Ron A M, Russell, Colin A, de Jong, Menno D, and Eggink, Dirk

Published
2024

27. Determinants of epidemic size and the impacts of lulls in seasonal influenza virus circulation

Author

Afd Chemical Biology and Drug Discovery, Sub Chemical Biology and Drug Discovery, Chemical Biology and Drug Discovery, de Jong, Simon P.J., Felix Garza, Zandra C., Gibson, Joseph C., van Leeuwen, Sarah, de Vries, Robert P., Boons, Geert Jan, van Hoesel, Marliek, de Haan, Karen, van Groeningen, Laura E., Hulme, Katina D., van Willigen, Hugo D.G., Wynberg, Elke, de Bree, Godelieve J., Matser, Amy, Bakker, Margreet, van der Hoek, Lia, Prins, Maria, Kootstra, Neeltje A., Eggink, Dirk, Nichols, Brooke E., Han, Alvin X., de Jong, Menno D., Russell, Colin A., Afd Chemical Biology and Drug Discovery, Sub Chemical Biology and Drug Discovery, Chemical Biology and Drug Discovery, de Jong, Simon P.J., Felix Garza, Zandra C., Gibson, Joseph C., van Leeuwen, Sarah, de Vries, Robert P., Boons, Geert Jan, van Hoesel, Marliek, de Haan, Karen, van Groeningen, Laura E., Hulme, Katina D., van Willigen, Hugo D.G., Wynberg, Elke, de Bree, Godelieve J., Matser, Amy, Bakker, Margreet, van der Hoek, Lia, Prins, Maria, Kootstra, Neeltje A., Eggink, Dirk, Nichols, Brooke E., Han, Alvin X., de Jong, Menno D., and Russell, Colin A.

Published
2024

28. Immunostimulatory Effect of Flagellin on MDR-Klebsiella-Infected Human Airway Epithelial Cells

Author

van Linge, Christine C.A., Hulme, Katina D., Peters-Sengers, Hessel, Sirard, Jean Claude, Goessens, Wil H.F., de Jong, Menno D., Russell, Colin A., de Vos, Alex F., van der Poll, Tom, van Linge, Christine C.A., Hulme, Katina D., Peters-Sengers, Hessel, Sirard, Jean Claude, Goessens, Wil H.F., de Jong, Menno D., Russell, Colin A., de Vos, Alex F., and van der Poll, Tom

Abstract

Pneumonia caused by multi-drug-resistant Klebsiella pneumoniae (MDR-Kpneu) poses a major public health threat, especially to immunocompromised or hospitalized patients. This study aimed to determine the immunostimulatory effect of the Toll-like receptor 5 ligand flagellin on primary human lung epithelial cells during infection with MDR-Kpneu. Human bronchial epithelial (HBE) cells, grown on an air–liquid interface, were inoculated with MDR-Kpneu on the apical side and treated during ongoing infection with antibiotics (meropenem) and/or flagellin on the basolateral and apical side, respectively; the antimicrobial and inflammatory effects of flagellin were determined in the presence or absence of meropenem. In the absence of meropenem, flagellin treatment of MDR-Kpneu-infected HBE cells increased the expression of antibacterial defense genes and the secretion of chemokines; moreover, supernatants of flagellin-exposed HBE cells activated blood neutrophils and monocytes. However, in the presence of meropenem, flagellin did not augment these responses compared to meropenem alone. Flagellin did not impact the outgrowth of MDR-Kpneu. Flagellin enhances antimicrobial gene expression and chemokine release by the MDR-Kpneu-infected primary human bronchial epithelium, which is associated with the release of mediators that activate neutrophils and monocytes. Topical flagellin therapy may have potential to boost immune responses in the lung during pneumonia.

Published
2024

29. High quality of SARS-CoV-2 molecular diagnostics in a diverse laboratory landscape through supported benchmark testing and External Quality Assessment

Author

Sluimer, John, van den Akker, Willem M.R., Goderski, Gabriel, Swart, Arno, van der Veer, Bas, Cremer, Jeroen, Chung, Ngoc Hoa, Molenkamp, Richard, Voermans, Jolanda, Guldemeester, Judith, van der Eijk, Annemiek, de Jong, Menno D., Mithoe, Glen, Hermans, Mirjam H.A., de Beer, Jessica L., Wessels, Els, von Wintersdorff, Christian, Pas, Suzan, Verweij, Jaco J., Melchers, Willem J.G., van de Bovenkamp, Jeroen H.B., Vahidnia, Ali, Gard, Lilli, Schuurman, Rob, Wintermans, Bas, Leversteijn-van Hall, Maurine, Smits, Paul, de Groot, Theun, Deiman, Birgit A.L.M., Bart, Aldert, van der Reijden, Wil, Svraka-Latifovic, Sanela, van der Zanden, Adri G.M., Thijsen, Steven, Schubbert, Rainer, Dreesens, Lisa L., van Duijn, Gert, Ong, David S.Y., Oostra, Monique, Bruisten, Sylvia, van Trijp, Marijke, Pettersson, Annika, van Burgel, Nathalie D., Oudbier, Joke, van der Linden, Michael, Rossen, John, Smit, Pieter, Thai, Khoa, Eggink, Dirk, Meijer, Adam, Sluimer, John, van den Akker, Willem M.R., Goderski, Gabriel, Swart, Arno, van der Veer, Bas, Cremer, Jeroen, Chung, Ngoc Hoa, Molenkamp, Richard, Voermans, Jolanda, Guldemeester, Judith, van der Eijk, Annemiek, de Jong, Menno D., Mithoe, Glen, Hermans, Mirjam H.A., de Beer, Jessica L., Wessels, Els, von Wintersdorff, Christian, Pas, Suzan, Verweij, Jaco J., Melchers, Willem J.G., van de Bovenkamp, Jeroen H.B., Vahidnia, Ali, Gard, Lilli, Schuurman, Rob, Wintermans, Bas, Leversteijn-van Hall, Maurine, Smits, Paul, de Groot, Theun, Deiman, Birgit A.L.M., Bart, Aldert, van der Reijden, Wil, Svraka-Latifovic, Sanela, van der Zanden, Adri G.M., Thijsen, Steven, Schubbert, Rainer, Dreesens, Lisa L., van Duijn, Gert, Ong, David S.Y., Oostra, Monique, Bruisten, Sylvia, van Trijp, Marijke, Pettersson, Annika, van Burgel, Nathalie D., Oudbier, Joke, van der Linden, Michael, Rossen, John, Smit, Pieter, Thai, Khoa, Eggink, Dirk, and Meijer, Adam

Abstract

A two-step strategy combining assisted benchmark testing (entry controls) and External Quality Assessments (EQAs) with blinded simulated clinical specimens to enhance and maintain the quality of nucleic acid amplification testing was developed. This strategy was successfully applied to 71 diagnostic laboratories in The Netherlands when upscaling the national diagnostic capacity during the SARS-CoV-2 pandemic. The availability of benchmark testing in combination with advice for improvement substantially enhanced the quality of the laboratory testing procedures for SARS-CoV-2 detection. The three subsequent EQA rounds demonstrated high quality testing with regard to specificity (99.6% correctly identified) and sensitivity (93.3% correctly identified). Even with the implementation of novel assays, changing workflows using diverse equipment and a high degree of assay heterogeneity, the overall high quality was maintained using this two-step strategy. We show that in contrast to the limited value of Cq value for absolute proxies of viral load, these Cq values can, in combination with metadata on strategies and techniques, provide valuable information for laboratories to improve their procedures. In conclusion, our two-step strategy (preparation phase followed by a series of EQAs) is a rapid and flexible system capable of scaling, improving, and maintaining high quality diagnostics even in a rapidly evolving (e.g. pandemic) situation.

Published
2024

30. Inflammatory profiles are associated with long COVID up to 6 months after COVID-19 onset: A prospective cohort study of individuals with mild to critical COVID-19.

Author

Wynberg, Elke, Han, Alvin X., van Willigen, Hugo D. G., Verveen, Anouk, van Pul, Lisa, Maurer, Irma, van Leeuwen, Ester M., van den Aardweg, Joost G., de Jong, Menno D., Nieuwkerk, Pythia, Prins, Maria, Kootstra, Neeltje A., and de Bree, Godelieve J.

Subjects
POST-acute COVID-19 syndrome, COVID-19, FIXED effects model, LONGITUDINAL method, MAGNETIC shielding
Abstract

Background: After initial COVID-19, immune dysregulation may persist and drive post-acute sequelae of COVID-19 (PASC). We described longitudinal trajectories of cytokines in adults up to 6 months following SARS-CoV-2 infection and explored early predictors of PASC. Methods: RECoVERED is a prospective cohort of individuals with laboratory-confirmed SARS-CoV-2 infection between May 2020 and June 2021 in Amsterdam, the Netherlands. Serum was collected at weeks 4, 12 and 24 of follow-up. Monthly symptom questionnaires were completed from month 2 after COVID-19 onset onwards; lung diffusion capacity (DLCO) was tested at 6 months. Cytokine concentrations were analysed by human magnetic Luminex screening assay. We used a linear mixed-effects model to study log-concentrations of cytokines over time, assessing their association with socio-demographic and clinical characteristics that were included in the model as fixed effects. Results: 186/349 (53%) participants had ≥2 serum samples and were included in current analyses. Of these, 101/186 (54%: 45/101[45%] female, median age 55 years [IQR = 45–64]) reported PASC at 12 and 24 weeks after COVID-19 onset. We included 37 reference samples (17/37[46%] female, median age 49 years [IQR = 40–56]). In a multivariate model, PASC was associated with raised CRP and abnormal diffusion capacity with raised IL10, IL17, IL6, IP10 and TNFα at 24 weeks. Early (0–4 week) IL-1β and BMI at COVID-19 onset were predictive of PASC at 24 weeks. Conclusions: Our findings indicate that immune dysregulation plays an important role in PASC pathogenesis, especially among individuals with reduced pulmonary function. Early IL-1β shows promise as a predictor of PASC. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

38. Antibody responses against SARS-CoV-2 variants induced by four different SARS-CoV-2 vaccines in health care workers in the Netherlands: A prospective cohort study

Author

van Gils, Marit J., Lavell, Ayesha, van der Straten, Karlijn, Appelman, Brent, Bontjer, Ilja, Poniman, Meliawati, Burger, Judith A., Oomen, Melissa, Bouhuijs, Joey H., van Vught, Lonneke A., Slim, Marleen A., Schinkel, Michiel, Wynberg, Elke, van Willigen, Hugo D. G., Grobben, Marloes, Tejjani, Khadija, van Rijswijk, Jacqueline, Snitselaar, Jonne L., Caniels, Tom G., Vlaar, Alexander P. J., Prins, Maria, de Jong, Menno D., de Bree, Godelieve J., Sikkens, Jonne J., Bomers, Marije K., and Sanders, Rogier W.

Subjects
Viral antibodies -- Evaluation -- Comparative analysis, Antibodies -- Evaluation -- Comparative analysis, Medical personnel -- Health aspects, Biological sciences
Abstract

Background Emerging and future SARS-CoV-2 variants may jeopardize the effectiveness of vaccination campaigns. Therefore, it is important to know how the different vaccines perform against diverse SARS-CoV-2 variants. Methods and findings In a prospective cohort of 165 SARS-CoV-2 naive health care workers in the Netherlands, vaccinated with either one of four vaccines (BNT162b2, mRNA-1273, AZD1222 or Ad26.COV2.S), we performed a head-to-head comparison of the ability of sera to recognize and neutralize SARS-CoV-2 variants of concern (VOCs; Alpha, Beta, Gamma, Delta and Omicron). Repeated serum sampling was performed 5 times during a year (from January 2021 till January 2022), including before and after booster vaccination with BNT162b2. Four weeks after completing the initial vaccination series, SARS-CoV-2 wild-type neutralizing antibody titers were highest in recipients of mRNA-1273, followed by recipients of BNT162b2 (geometric mean titers (GMT) of 358 [95% CI 231-556] and 214 [95% CI 153-299], respectively; p Conclusions Overall, this study shows that the mRNA vaccines appear superior to adenovirus vector-based vaccines in inducing neutralizing antibodies against VOCs four weeks after initial vaccination and after booster vaccination, which implies the use of mRNA vaccines for both initial and booster vaccination., Author(s): Marit J. van Gils 1,*, Ayesha Lavell 2, Karlijn van der Straten 1,3, Brent Appelman 4, Ilja Bontjer 1, Meliawati Poniman 1, Judith A. Burger 1, Melissa Oomen 1, [...]

Published
2022
Full Text
View/download PDF

39. Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19

Author

Zatz, Mayana, Beudel, Martijn, Bos, Lieuwe, Botta, Michela, de Brabander, Justin, de Bree, Godelieve, de Bruin, Sanne, Bulle, Esther, Dijkstra, Mirjam, Dongelmans, Dave A., Dujardin, Romein W. G., Goorhuis, Bram, Grobusch, Martin P., Hafkamp, Florianne, Hagens, Laura, Hamann, Jorg, Harris, Vanessa, Hemke, Robert, Hollmann, Markus, Horn, Janneke, Hovius, Joppe W., de Jong, Menno D., Lim, Endry H. T., van Mourik, Niels, Paulus, Frederique, Pina-Fuentes, Dan A. I., Prins, Jan M., Raasveld, Jorinde, Reijnders, Tom, de Rotte, Maurits C. F. J., Schultz, Marcus J., Schrauwen, Femke A. P., Schuurmans, Jaap, Sigaloff, Kim, Slim, Marleen A., Smit, Marry, Stijnis, Cornelis S., Stilma, Willemke, van der Valk, Marc, Veelo, Denise, Volleman, Carolien, van Vugt, Michèle, Zwinderman, A. H., Wiersinga, W. Joost, Vlaar, Alexander P. J., Neurology, AII - Infectious diseases, ANS - Neuroinfection & -inflammation, Center of Experimental and Molecular Medicine, Graduate School, ANS - Neurodegeneration, Pulmonology, ACS - Pulmonary hypertension & thrombosis, AII - Inflammatory diseases, Intensive Care Medicine, ACS - Heart failure & arrhythmias, Infectious diseases, APH - Aging & Later Life, APH - Global Health, ACS - Amsterdam Cardiovascular Sciences, Laboratory Specialized Diagnostics & Research, APH - Quality of Care, Anesthesiology, AII - Amsterdam institute for Infection and Immunity, Experimental Immunology, Global Health, APH - Health Behaviors & Chronic Diseases, Radiology and Nuclear Medicine, AMS - Musculoskeletal Health, AMS - Sports, ACS - Microcirculation, Medical Microbiology and Infection Prevention, ANS - Amsterdam Neuroscience, Nursing, Central Diagnostic Laboratory, ACS - Diabetes & metabolism, APH - Digital Health, APH - Personalized Medicine, Epidemiology and Data Science, APH - Methodology, and AII - Cancer immunology

Abstract

Background: We previously reported that impaired type I IFN activity, due to inborn errors of TLR3- and TLR7-dependent type I interferon (IFN) immunity or to autoantibodies against type I IFN, account for 15–20% of cases of life-threatening COVID-19 in unvaccinated patients. Therefore, the determinants of life-threatening COVID-19 remain to be identified in ~ 80% of cases. Methods: We report here a genome-wide rare variant burden association analysis in 3269 unvaccinated patients with life-threatening COVID-19, and 1373 unvaccinated SARS-CoV-2-infected individuals without pneumonia. Among the 928 patients tested for autoantibodies against type I IFN, a quarter (234) were positive and were excluded. Results: No gene reached genome-wide significance. Under a recessive model, the most significant gene with at-risk variants was TLR7, with an OR of 27.68 (95%CI 1.5–528.7, P = 1.1 × 10−4) for biochemically loss-of-function (bLOF) variants. We replicated the enrichment in rare predicted LOF (pLOF) variants at 13 influenza susceptibility loci involved in TLR3-dependent type I IFN immunity (OR = 3.70[95%CI 1.3–8.2], P = 2.1 × 10−4). This enrichment was further strengthened by (1) adding the recently reported TYK2 and TLR7 COVID-19 loci, particularly under a recessive model (OR = 19.65[95%CI 2.1–2635.4], P = 3.4 × 10−3), and (2) considering as pLOF branchpoint variants with potentially strong impacts on splicing among the 15 loci (OR = 4.40[9%CI 2.3–8.4], P = 7.7 × 10−8). Finally, the patients with pLOF/bLOF variants at these 15 loci were significantly younger (mean age [SD] = 43.3 [20.3] years) than the other patients (56.0 [17.3] years; P = 1.68 × 10−5). Conclusions: Rare variants of TLR3- and TLR7-dependent type I IFN immunity genes can underlie life-threatening COVID-19, particularly with recessive inheritance, in patients under 60 years old.

Published
2023

41. Ebola Virus Inactivation by Detergents Is Annulled in Serum

Author

van Kampen, Jeroen J. A., Tintu, Andrei, Russcher, Henk, Fraaij, Pieter L. A., Reusken, Chantal B. E. M., Rijken, Mikel, van Hellemond, Jaap J., van Genderen, Perry J. J., Koelewijn, Rob, de Jong, Menno D., Haddock, Elaine, Fischer, Robert J., Munster, Vincent J., and Koopmans, Marion P. G.

Published
2017

44. Comparative analysis of spike-specific IgG Fc glycoprofiles elicited by adenoviral, mRNA, and protein-based SARS-CoV-2 vaccines

Author

Van Coillie, Julie, primary, Pongracz, Tamas, additional, Šuštić, Tonći, additional, Wang, Wenjun, additional, Nouta, Jan, additional, Le Gars, Mathieu, additional, Keijzer, Sofie, additional, Linty, Federica, additional, Cristianawati, Olvi, additional, Keijser, Jim B.D., additional, Visser, Remco, additional, van Vught, Lonneke A., additional, Slim, Marleen A., additional, van Mourik, Niels, additional, Smit, Merel J., additional, Sander, Adam, additional, Schmidt, David E., additional, Steenhuis, Maurice, additional, Rispens, Theo, additional, Nielsen, Morten A., additional, Mordmüller, Benjamin G., additional, Vlaar, Alexander P.J., additional, Ellen van der Schoot, C., additional, Roozendaal, Ramon, additional, Wuhrer, Manfred, additional, Vidarsson, Gestur, additional, Appelman, Brent, additional, van de Beek, Diederik, additional, Bomers, Marije K., additional, de Brabander, Justin, additional, Brouwer, Matthijs C., additional, Buis, David T.P., additional, Chekrouni, Nora, additional, van Gils, Marit J., additional, de Jong, Menno D., additional, Lavell, Ayesha H.A., additional, Olie, Sabine E., additional, Peters, Edgar J.G., additional, Reijnders, Tom D.Y., additional, Schinkel, Michiel, additional, Schuurman, Alex R., additional, Sikkens, Jonne J., additional, Smulders, Yvo M., additional, Wiersinga, Joost W., additional, Spinello, Antinori, additional, Bassoli, Cinzia, additional, Bestetti, Giovanna, additional, Corbellino, Mario, additional, Covizzi, Alice, additional, Lupo, Angelica, additional, Milazzo, Laura, additional, Schiuma, Marco, additional, Torre, Alessandro, additional, de Jongh, Willem A., additional, Salanti, Ali, additional, Theander, Thor G., additional, McCall, Matthew B.B., additional, and Esen, Meral, additional

Published
2023
Full Text
View/download PDF

47. Import and spread of extended-spectrum β-lactamase-producing Enterobacteriaceae by international travellers (COMBAT study): a prospective, multicentre cohort study

Author

Arcilla, Maris S, van Hattem, Jarne M, Haverkate, Manon R, Bootsma, Martin C J, van Genderen, Perry J J, Goorhuis, Abraham, Grobusch, Martin P, Lashof, Astrid M Oude, Molhoek, Nicky, Schultsz, Constance, Stobberingh, Ellen E, Verbrugh, Henri A, de Jong, Menno D, Melles, Damian C, and Penders, John

Published
2017
Full Text
View/download PDF

48. Author Correction: Global phylogenetic analysis of Escherichia coli and plasmids carrying the mcr-1 gene indicates bacterial diversity but plasmid restriction

Author

Matamoros, Sébastien, van Hattem, Jarne M., Arcilla, Maris S., Willemse, Niels, Melles, Damian C., Penders, John, Vinh, Trung Nguyen, Thi Hoa, Ngo, Bootsma, Martin C. J., Genderen, Perry J. van, Goorhuis, Abraham, Grobusch, Martin, Molhoek, Nicky, Oude Lashof, Astrid M. L., Stobberingh, Ellen E., Verbrugh, Henri A., de Jong, Menno D., and Schultsz, Constance

Published
2020
Full Text
View/download PDF

49. Immunostimulatory Effect of Flagellin on MDR- Klebsiella -Infected Human Airway Epithelial Cells.

Author

van Linge, Christine C. A., Hulme, Katina D., Peters-Sengers, Hessel, Sirard, Jean-Claude, Goessens, Wil H. F., de Jong, Menno D., Russell, Colin A., de Vos, Alex F., and van der Poll, Tom

Subjects
FLAGELLIN, EPITHELIAL cells, LUNGS, KLEBSIELLA, KLEBSIELLA pneumoniae, TOLL-like receptors
Abstract

Pneumonia caused by multi-drug-resistant Klebsiella pneumoniae (MDR-Kpneu) poses a major public health threat, especially to immunocompromised or hospitalized patients. This study aimed to determine the immunostimulatory effect of the Toll-like receptor 5 ligand flagellin on primary human lung epithelial cells during infection with MDR-Kpneu. Human bronchial epithelial (HBE) cells, grown on an air–liquid interface, were inoculated with MDR-Kpneu on the apical side and treated during ongoing infection with antibiotics (meropenem) and/or flagellin on the basolateral and apical side, respectively; the antimicrobial and inflammatory effects of flagellin were determined in the presence or absence of meropenem. In the absence of meropenem, flagellin treatment of MDR-Kpneu-infected HBE cells increased the expression of antibacterial defense genes and the secretion of chemokines; moreover, supernatants of flagellin-exposed HBE cells activated blood neutrophils and monocytes. However, in the presence of meropenem, flagellin did not augment these responses compared to meropenem alone. Flagellin did not impact the outgrowth of MDR-Kpneu. Flagellin enhances antimicrobial gene expression and chemokine release by the MDR-Kpneu-infected primary human bronchial epithelium, which is associated with the release of mediators that activate neutrophils and monocytes. Topical flagellin therapy may have potential to boost immune responses in the lung during pneumonia. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

50. Aberrant neutrophil degranulation in hospitalized patients with COVID‐19 partially remains for 6 months.

Author

Hafkamp, Florianne M.J., Taanman‐Kueter, Esther W. M., van Capel, Toni M. M., Wynberg, Elke, van Willigen, Hugo D. G., Verveen, Anouk, Kootstra, Neeltje A., Nieuwkerk, Pythia, de Jong, Menno D., de Bree, Godelieve J., Prins, Maria, Hazenberg, Mette D., Groot Kormelink, Tom, and de Jong, Esther C.

Subjects
COVID-19, PULMONARY alveolar proteinosis, HOSPITAL patients, LEUCOCYTE elastase, GRANULOCYTE-macrophage colony-stimulating factor, COVID-19 pandemic
Abstract

Neutrophils are important players in COVID‐19, contributing to tissue damage by release of inflammatory mediators, including ROS and neutrophil elastase. Longitudinal studies on the effects of COVID‐19 on neutrophil phenotype and function are scarce. Here, we longitudinally investigated the phenotype and degranulation of neutrophils in COVID‐19 patients (28 nonhospitalized and 35 hospitalized patients) compared with 17 healthy donors (HDs). We assessed phenotype, degranulation, CXCL8 (IL‐8) release, and ROS generation within 8 days, at one or 6 month(s) after COVID‐19 diagnosis. For degranulation and ROS production, we stimulated neutrophils, either with ssRNA and TNF or granulocyte‐macrophage colony‐stimulating factor and N‐Formylmethionyl‐leucyl‐phenylalanine. During active COVID‐19, neutrophils from hospitalized patients were more immature than from HDs and were impaired in degranulation and ROS generation, while neutrophils from nonhospitalized patients only demonstrated reduced CD66b+ granule release and ROS production. Baseline CD63 expression, indicative of primary granule release, and CXCL8 production by neutrophils from hospitalized patients were elevated for up to 6 months. These findings show that patients hospitalized due to COVID‐19, but not nonhospitalized patients, demonstrated an aberrant neutrophil phenotype, degranulation, CXCL8 release, and ROS generation that partially persists up to 6 months after infection. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results