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1. Management of Acromioclavicular Injuries – Current Concepts

Author

de Groot C, Verstift DE, Heisen J, van Deurzen DFP, and van den Bekerom MPJ

Subjects
acromioclavicular joint injury, rehabilitation, operative treatment, rockwood classification, instability, semitendinosus graft., Orthopedic surgery, RD701-811, Diseases of the musculoskeletal system, RC925-935
Abstract

Charlotte de Groot,1 Daniel E Verstift,2 Jelle Heisen,3 Derek FP van Deurzen,2 Michel PJ van den Bekerom2,4 1Department of Orthopaedic Surgery and Trauma Surgery, OLVG, Amsterdam, the Netherlands; 2Shoulder and Elbow Unit, Joint Research, Department of Orthopaedic Surgery and Trauma Surgery, OLVG, Amsterdam, the Netherlands; 3Movamento, Amsterdam, the Netherlands; 4Department of Human Movement Sciences, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Amsterdam, the NetherlandsCorrespondence: Charlotte de Groot, Department of Orthopaedic Surgery and Trauma Surgery, OLVG, P.O. Box 95500, Amsterdam, 1090 HM, the Netherlands, Email C.deGroot2@olvg.nlIntroduction: Treatment of a patient with acromioclavicular joint (ACJ) injury remains challenging for orthopedic surgeons. To date, there is debate over the optimal management of ACJ injuries. This review provides an overview of assessment, treatment, and future perspectives for the treatment of and research into ACJ.Material and Methods: A scoping literature review was performed. The search was built including the following terms: acromioclavicular joint injuries or dislocation, and pathophysiology, etiology, anatomy, treatment, and trauma mechanism. The papers with evidence levels 1– 3 were included in the current narrative review.Results: A total of 2242 potential relevant studies were identified in the searches. After removal of duplicates, 432 studies were screened on their titles and abstracts, resulting in 35 studies being included in the review, based on the eligibility criteria.Conclusion: The management of acute and chronic ACJ injuries is not clarified in the current literature. However, there is currently insufficient high-level evidence for the overall treatment options for ACJ injuries. If surgical intervention is decided upon in consultation with the patient, the complications may not outweigh the benefits. The multitude of existing techniques is indicative of the uncertainty surrounding this issue, and no gold standard has yet been established for treatment methods. An ideal classification would include not only vertical and horizontal instability, but also the severity of kinematic alterations of the shoulder complex. This indicates the need for a new and improved diagnostic tool for the classification of ACJ injuries.Keywords: acromioclavicular joint injury, rehabilitation, operative treatment, Rockwood classification, instability, semitendinosus graft

Published
2023

2. Inverse design of structural color: finding multiple solutions via conditional generative adversarial networks

Author

Dai Peng, Sun Kai, Yan Xingzhao, Muskens Otto L., de Groot C. H. (Kees), Zhu Xupeng, Hu Yueqiang, Duan Huigao, and Huang Ruomeng

Subjects
deep learning, fabry–pérot cavity, generative adversarial networks, inverse design, one-to-many problem, structural color, Physics, QC1-999
Abstract

The “one-to-many” problem is a typical challenge that faced by many machine learning aided inverse nanophotonics designs where one target optical response can be achieved by many solutions (designs). Although novel training approaches, such as tandem network, and network architecture, such as the mixture density model, have been proposed, the critical problem of solution degeneracy still exists where some possible solutions or solution spaces are discarded or unreachable during the network training process. Here, we report a solution to the “one-to-many” problem by employing a conditional generative adversarial network (cGAN) that enables generating sets of multiple solution groups to a design problem. Using the inverse design of a transmissive Fabry–Pérot-cavity-based color filter as an example, our model demonstrates the capability of generating an average number of 3.58 solution groups for each color. These multiple solutions allow the selection of the best design for each color which results in a record high accuracy with an average index color difference ΔE of 0.44. The capability of identifying multiple solution groups can benefit the design manufacturing to allow more viable designs for fabrication. The capability of our cGAN is verified experimentally by inversely designing the RGB color filters. We envisage this cGAN-based design methodology can be applied to other nanophotonic structures or physical science domains where the identification of multi-solution across a vast parameter space is required.

Published
2022
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3. The 2024 Active Metamaterials Roadmap

Author

Pope, Simon A., Roth, Diane J., Bansal, Aakash, Mousa, Mostafa, Rezanejad, Ashkan, Forte, Antonio E., Nash, Geoff. R., Singleton, Lawrence, Langfeldt, Felix, Cheer, Jordan, Henthorn, Stephen, Hooper, Ian R., Hendry, Euan, Powell, Alex W., Souslov, Anton, Plum, Eric, Sun, Kai, de Groot, C. H., Muskens, Otto L., Shields, Joe, De Galarreta, Carlota Ruiz, Wright, C. David, Kocabas, Coskun, Ergoktas, M. Said, Xiao, Jianling, Schulz, Sebastian A., Di Falco, Andrea, Krasavin, Alexey V., Zayats, Anatoly V., and Galiffi, Emanuele

Subjects
Physics - Applied Physics, Physics - Optics
Abstract

Active metamaterials are engineered structures that possess novel properties that can be changed after the point of manufacture. Their novel properties arise predominantly from their physical structure, as opposed to their chemical composition and can be changed through means such as direct energy addition into wave paths, or physically changing/morphing the structure in response to both a user or environmental input. Active metamaterials are currently of wide interest to the physics community and encompass a range of sub-domains in applied physics (e.g. photonic, microwave, acoustic, mechanical, etc.). They possess the potential to provide solutions that are more suitable to specific applications, or which allow novel properties to be produced which cannot be achieved with passive metamaterials, such as time-varying or gain enhancement effects. They have the potential to help solve some of the important current and future problems faced by the advancement of modern society, such as achieving net-zero, sustainability, healthcare and equality goals. Despite their huge potential, the added complexity of their design and operation, compared to passive metamaterials creates challenges to the advancement of the field, particularly beyond theoretical and lab-based experiments. This roadmap brings together experts in all types of active metamaterials and across a wide range of areas of applied physics. The objective is to provide an overview of the current state of the art and the associated current/future challenges, with the hope that the required advances identified create a roadmap for the future advancement and application of this field.

Published
2024

6. Modelling Resistive and Phase Change Memory with Passive Selector Arrays -- A Matlab Tool

Author

Noori, Yasir J and de Groot, C H

Subjects
Computer Science - Neural and Evolutionary Computing, Physics - Applied Physics
Abstract

Memristor devices are crucial for developing neuromorphic computers and next-generation memory technologies. In this work, we provide a comprehensive modelling tool for simulating static DC reading operations of memristor crossbar arrays that use passive selectors with matrix algebra in MATLAB. The software tool was parallel coded and optimized to run with personal computers and distributed computer clusters with minimized CPU and memory consumption. Using the tool, we demonstrate the effect of changing the line resistance, array size, voltage selection scheme, selector diode's ideality factor, reverse saturation current, temperature and sense resistance on the electrical behavior and expected sense margin of one-diode-one-resistor crossbar arrays. We then investigate the effect of single and dual side array biasing and grounding on the dissipated current throughout the array cells. The tool we offer to the memristor community and the studies we present enables the design of larger and more practical memristor arrays for application in data storage and neuromorphic computing., Comment: 9 pages, 16 figures, open-access code

Published
2019

8. High-fidelity phase and amplitude control of phase-only computer generated holograms using conjugate gradient minimisation

Author

Bowman, D., Harte, T. L., Chardonnet, V., De Groot, C., Denny, S. J., Goc, G. Le, Anderson, M., Ireland, P., Cassettari, D., and Bruce, G. D.

Subjects
Physics - Optics, Condensed Matter - Quantum Gases, Physics - Atomic Physics
Abstract

We demonstrate simultaneous control of both the phase and amplitude of light using a conjugate gradient minimisation-based hologram calculation technique and a single phase-only spatial light modulator (SLM). A cost function which incorporates the inner product of the light field with a chosen target field within a defined measure region is efficiently minimised to create high fidelity patterns in the Fourier plane of the SLM. A fidelity of $F=0.999997$ is achieved for a pattern resembling an $LG^{0}_{1}$ mode with a calculated light-usage efficiency of $41.5\%$. Possible applications of our method in optical trapping and ultracold atoms are presented and we show uncorrected experimental realisation of our patterns with $F = 0.97$ and $7.8\%$ light efficiency.

Published
2017
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12. Congenital heart disease in the ESC EORP Registry of Pregnancy and Cardiac disease (ROPAC)

Author

Hall, Roger, Roos-Hesselink, Jolien, Stein, Joerg, Parsonage, William Anthony, Budts, Werner, De Backer, Julie, Grewal, Jasmin, Marelli, Ariane, Kaemmerer, Harald, Jondeau, Guillaume, Johnson, Mark, Maggioni, Aldo P., Tavazzi, Luigi, Thilen, Ulf, Elkayam, Uri, Otto, Catherine, Sliwa, Karen, Aquieri, A., Saad, A., Vega, H. Ruda, Hojman, J., Caparros, J.M., Blanco, M. Vazquez, Arstall, M., Chung, C.M., Mahadavan, G., Aldridge, E., Wittwer, M., Chow, Y.Y., Parsonage, W.A., Lust, K., Collins, N., Warner, G., Hatton, R., Gordon, A., Nyman, E., Stein, J., Donhauser, E., Gabriel, H., Bahshaliyev, A., Guliyev, F., Hasanova, I., Jahangirov, T., Gasimov, Z., Salim, A., Ahmed, C.M., Begum, F., Hoque, M.H., Mahmood, M., Islam, M.N., Haque, P.P., Banerjee, S.K., Parveen, T., Morissens, M., De Backer, J., Demulier, L., de Hosson, M., Budts, W., Beckx, M., Kozic, M., Lovric, M., Kovacevic-Preradovic, T., Chilingirova, N., Kratunkov, P., Wahab, N., McLean, S., Gordon, E., Walter, L., Marelli, A., Montesclaros, A.R., Monsalve, G., Rodriguez, C., Balthazar, F., Quintero, V., Palacio, W., Cadavid, L.A. Mejía, Ortiz, E. Munoz, Hoyos, F. Fortich, Guerrero, E. Arevalo, Ricardo, J. Gandara, Penagos, J. Velasquez, Vavera, Z., Prague, Popelova, J., Vejlstrup, N., Grønbeck, L., Johansen, M., Ersboll, A., Elrakshy, Y., Eltamawy, K., Abd-El Aziz, M. Gamal, El Nagar, A., Ebaid, H., Elenin, H. Abo, Saed, M., Farag, S., Makled, W., Sorour, K., Ashour, Z., El-Sayed, G., Meguid Mahdy, M. Abdel, Taha, N., Dardeer, A., Shabaan, M., Ali, M., Moceri, P., Duthoit, G., Gouton, M., Nizard, J., Baris, L., Cohen, S., Ladouceur, M., Khimoud, D., Iung, B., Berger, F., Olsson, A., Gembruch, U., Merz, W.M., Reinert, E., Clade, S., Kliesch, Y., Wald, C., Sinning, C., Kozlik-Feldmann, R., Blankenberg, S., Zengin-Sahm, E., Mueller, G., Hillebrand, M., Hauck, P., von Kodolitsch, Y., Zarniko, N., Baumgartner, Muenster H., Schmidt, R., Hellige, A., Tutarel, O., Kaemmerer, H., Kuschel, B., Nagdyman, N., Motz, R., Maisuradze, D., Frogoudaki, A., Iliodromitis, E., Anastasiou-Nana, M., Marousi, Triantafyllis, D., Bekiaris, G., Karvounis, H., Giannakoulas, G., Ntiloudi, D., Mouratoglou, S.A., Temesvari, A., Balint, H., Kohalmi, D., Merkely, B., Liptai, C., Nemes, A., Forster, T., Kalapos, A., Berek, K., Havasi, K., Ambrus, N., Shelke, A., Kawade, R., Patil, S., Martanto, E., Aprami, T.M., Purnomowati, A., Cool, C.J., Hasan, M., Akbar, R., Hidayat, S., Dewi, T.I., Permadi, W., Soedarsono, D.A., Ansari-Ramandi, M.M., Samiei, N., Tabib, A., Kashfi, F., Ansari-Ramandi, S., Rezaei, S., Farhan, H. Ali, Al-Hussein, A., Al-Saedi, G., Mahmood, G., Yaseen, I.F., Al-Yousuf, L., AlBayati, M., Mahmood, S., Raheem, S., AlHaidari, T., Dakhil, Z., Thornton, P., Donnelly, J., Bowen, M., Blatt, A., Elbaz-Greener, G., Shotan, A., Yalonetsky, S., Goland, S., Biener, M., Assenza, G. Egidy, Bonvicini, M., Donti, A., Bulgarelli, A., Prandstraller, D., Romeo, C., Crepaz, R., Sciatti, E., Metra, M., Orabona, R., Ali, L. Ait, Festa, P., Fesslova, V., Bonanomi, C., Calcagnino, M., Lombardi, F., Colli, A.M., Ossola, M.W., Gobbi, C., Gherbesi, E., Tondi, L., Schiavone, M., Squillace, M., Carmina, M.G., Maina, A., Macchi, C., Gollo, E., Comoglio, F.M., Montali, N., Re, P., Bordese, R., Todros, T., Donvito, V., Marra, W. Grosso, Sinagra, G., D'Agata Mottolese, B., Bobbo, M., Gesuete, V., Rakar, S., Ramani, F., Niwa, K., Mekebekova, D., Mussagaliyeva, A., Lee, T., Mirrakhimov, E., Abilova, S., Bektasheva, E., Neronova, K., Lunegova, O., Žaliūnas, R., Jonkaitienė, R., Petrauskaitė, J., Laucevicius, A., Jancauskaite, D., Lauciuviene, L., Gumbiene, L., Lankutiene, L., Glaveckaite, S., Laukyte, M., Solovjova, S., Rudiene, V., Chee, K.H., Yim, C.C.-W., Ang, H.L., Kuppusamy, R., Watson, T., Caruana, M., Estensen, M.-E., Kayani, M.G.A. Mahmood, Munir, R., Tomaszuk-Kazberuk, A., Sobkowicz, B., Przepiesc, J., Lesniak-Sobelga, A., Tomkiewicz-Pajak, L., Komar, M., Olszowska, M., Podolec, P., Wisniowska-Smialek, S., Lelonek, M., Faflik, U., Cichocka-Radwan, A., Plaskota, K., Trojnarska, O., Guerra, N., de Sousa, L., Cruz, C., Ribeiro, V., Jovanova, S., Petrescu, V., Jurcut, R., Ginghina, C., Coman, I. Mircea, Musteata, M., Osipova, O., Golivets, T., Khamnagadaev, I., Golovchenko, O., Nagibina, A., Ropatko, I., Gaisin, I.R., Shilina, L. Valeryevna, Sharashkina, N., Shlyakhto, E., Irtyuga, O., Moiseeva, O., Karelkina, E., Zazerskaya, I., Kozlenok, A., Sukhova, I., Jovovic, L., Prokšelj, K., Koželj, M., Askar, A.O., Abdilaahi, A.A., Mohamed, M.H., Dirir, A.M., Sliwa, K., Manga, P., Pijuan-Domenech, A., Galian-Gay, L., Tornos, P., Subirana, M.T., T, M., Subirana, Oliver, J.M., Garcia-Aranda Dominguez, B., Gonzalez, I. Hernandez, Jimenez, J.F. Delgado, Subias, P. Escribano, Murga, N., Elbushi, A., Suliman, A., Jazzar, K., Murtada, M., Ahamed, N., Dellborg, M., Furenas, E., Jinesjo, M., Skoglund, K., Eriksson, P., Gilljam, T., Thilen, U., Tobler, D., Wustmann, K., Schwitz, F., Schwerzmann, M., Rutz, T., Bouchardy, J., Greutmann, M., Lopes, B.M. Santos, Meier, L., Arrigo, M., de Boer, K., Konings, T., Wajon, E., Wagenaar, L.J., Polak, P., Pieper, E.P.G., Roos-Hesselink, J., van Hagen, I., Duvekot, H., Cornette, J.M.J., De Groot, C., van Oppen, C., Sarac, L., Esen, O. Batukan, Enar, S. Catirli, Mondo, C., Ingabire, P., Nalwanga, B., Semu, T., Salih, B.T., Almahmeed, W.A.R., Wani, S., Farook, F.S. Mohamed, Ain, Al, Gerges, F., Komaranchath, A.M., Al bakshi, F., Al Mulla, A., Yusufali, A.H., Al Hatou, E.I., Bazargani, N., Hussain, F., Hudsmith, L., Thompson, P., Thorne, S., Bowater, S., Money-Kyrle, A., Clifford, P., Ramrakha, P., Firoozan, S., Chaplin, J., Bowers, N., Adamson, D., Schroeder, F., Wendler, R., Hammond, S., Nihoyannopoulos, P., Norfolk, Norwich, Hall, R., Freeman, L., Veldtman, G., Kerr, J., Tellett, L., Scott, N., Bhatt, A.B., DeFaria Yeh, D., Youniss, M.A., Wood, M., Sarma, A.A., Tsiaras, S., Stefanescu, A., Duran, J.M., Stone, L., Majdalany, D.S., Chapa, J., Chintala, K., Gupta, P., Botti, J., Ting, J., Davidson, W.R., Wells, G., Sparks, D., Paruchuri, V., Marzo, K., Patel, D., Wagner, W., Ahanya, S.N., Colicchia, L., Jentink, T., Han, K., Loichinger, M., Parker, M., Longtin, C., Yetman, A., Erickson, K., Cramer, J., Tsai, S., Fletcher, B., Warta, S., Cohen, C., Lindblade, C., Puntel, R., Nagaran, K., Croft, N., Gurvitz, M., Otto, C., Talluto, C., Murphy, D., Perlroth, M.G., Ramlakhan, Karishma P., Johnson, Mark R., Lelonek, Malgorzata, Saad, Aly, Gasimov, Zaur, Sharashkina, Natalia V., Thornton, Patrick, Arstall, Margaret, and Roos-Hesselink, Jolien W.

Published
2021
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14. Effect of COVID-19 lockdown on maternity care and maternal outcome in the Netherlands: a national quasi-experimental study

Author

Epi Infectieziekten Team 1, MS Verloskunde, Child Health, Arts-assistenten DV&B, Onderzoeksgroep 2, Zorgeenheid Vaatchirurgie Medisch, Team Onderzoek, Brain, Onderzoeksgroep 6, CMM Sectie Molecular Cancer Research, Opleiding Neurologie, Gravesteijn, B. Y., Boderie, N. W., van den Akker, T., Bertens, L. C.M., Bloemenkamp, K., Burgos Ochoa, L., de Jonge, A., Kazemier, B. M., Klein, P. P., Kwint-Reijnders, I., Labrecque, J., Mol, B. W., Obermann, S., Peters, L., Ravelli, A. C.J., Rosman, A., Been, J., de Groot, C. J., Ambrosino, E., Auweele, K. V., Beijers, R., Boderie, N., Burdorf, L., Ochoa, L. B., de Weerth, C., Franx, A., Harper, S., Kretz, D., Muris, J., Nieuwenhuijze, M., Oudijk, M., Ramerman, L., Ravelli, A., Schonewille-Rosman, A., Struijs, J., Torij, H., Van Beukering, M., van den Heuvel, M., van Dillen, J., van Lenthe, F., Van Ourti, T., Verhoeff, A., Vermeulen, M., Visser, N., Willers, S., Schoenmakers, S., Zainularab, Z., Epi Infectieziekten Team 1, MS Verloskunde, Child Health, Arts-assistenten DV&B, Onderzoeksgroep 2, Zorgeenheid Vaatchirurgie Medisch, Team Onderzoek, Brain, Onderzoeksgroep 6, CMM Sectie Molecular Cancer Research, Opleiding Neurologie, Gravesteijn, B. Y., Boderie, N. W., van den Akker, T., Bertens, L. C.M., Bloemenkamp, K., Burgos Ochoa, L., de Jonge, A., Kazemier, B. M., Klein, P. P., Kwint-Reijnders, I., Labrecque, J., Mol, B. W., Obermann, S., Peters, L., Ravelli, A. C.J., Rosman, A., Been, J., de Groot, C. J., Ambrosino, E., Auweele, K. V., Beijers, R., Boderie, N., Burdorf, L., Ochoa, L. B., de Weerth, C., Franx, A., Harper, S., Kretz, D., Muris, J., Nieuwenhuijze, M., Oudijk, M., Ramerman, L., Ravelli, A., Schonewille-Rosman, A., Struijs, J., Torij, H., Van Beukering, M., van den Heuvel, M., van Dillen, J., van Lenthe, F., Van Ourti, T., Verhoeff, A., Vermeulen, M., Visser, N., Willers, S., Schoenmakers, S., and Zainularab, Z.

Published
2024

15. Effect of COVID-19 lockdown on maternity care and maternal outcome in the Netherlands:a national quasi-experimental study

Author

Gravesteijn, B. Y., Boderie, N., van den Akker, T., Bertens, L. C.M., Bloemenkamp, K., Burgos Ochoa, L., de Jonge, A., Kazemier, B. M., Klein, P. P., Kwint-Reijnders, I., Labrecque, J. A., Mol, B. W., Obermann-Borst, S. A., Peters, L., Ravelli, A. C.J., Schonewille-Rosman, A., Been, J., de Groot, C. J., Ambrosino, E., Auweele, K. V., Beijers, R., Burdorf, L., de Weerth, C., Franx, A., Harper, S., Kretz, D., Muris, J., Nieuwenhuijze, M., Oudijk, M., Ramerman, L., Ravelli, A., Struijs, J., Torij, H., Van Beukering, M., van den Heuvel, M., van Dillen, J., van Lenthe, F., Van Ourti, T., Verhoeff, A., Vermeulen, M., Visser, N., Willers, S., Schoenmakers, S., Zainularab, Z., Gravesteijn, B. Y., Boderie, N., van den Akker, T., Bertens, L. C.M., Bloemenkamp, K., Burgos Ochoa, L., de Jonge, A., Kazemier, B. M., Klein, P. P., Kwint-Reijnders, I., Labrecque, J. A., Mol, B. W., Obermann-Borst, S. A., Peters, L., Ravelli, A. C.J., Schonewille-Rosman, A., Been, J., de Groot, C. J., Ambrosino, E., Auweele, K. V., Beijers, R., Burdorf, L., de Weerth, C., Franx, A., Harper, S., Kretz, D., Muris, J., Nieuwenhuijze, M., Oudijk, M., Ramerman, L., Ravelli, A., Struijs, J., Torij, H., Van Beukering, M., van den Heuvel, M., van Dillen, J., van Lenthe, F., Van Ourti, T., Verhoeff, A., Vermeulen, M., Visser, N., Willers, S., Schoenmakers, S., and Zainularab, Z.

Abstract

OBJECTIVES:The COVID-19 pandemic and associated lockdowns disrupted health care worldwide. High-income countries observed a decrease in preterm births during lockdowns, but maternal pregnancy-related outcomes were also likely affected. This study investigates the effect of the first COVID-19 lockdown (March-June 2020) on provision of maternity care and maternal pregnancy-related outcomes in the Netherlands.STUDY DESIGN: National quasi-experimental study.METHODS: Multiple linked national registries were used, and all births from a gestational age of 24+0 weeks in 2010-2020 were included. In births starting in midwife-led primary care, we assessed the effect of lockdown on provision of care. In the general pregnant population, the impact on characteristics of labour and maternal morbidity was assessed. A difference-in-regression-discontinuity design was used to derive causal estimates for the year 2020.RESULTS: A total of 1,039,728 births were included. During the lockdown, births to women who started labour in midwife-led primary care (49%) more often ended at home (27% pre-lockdown, +10% [95% confidence interval: +7%, +13%]). A small decrease was seen in referrals towards obstetrician-led care during labour (46%, -3% [-5%,-0%]). In the overall group, no significant change was seen in induction of labour (27%, +1% [-1%, +3%]). We found no significant changes in the incidence of emergency caesarean section (9%, -1% [-2%, +0%]), obstetric anal sphincter injury (2%, +0% [-0%, +1%]), episiotomy (21%, -0% [-2%, +1%]), or post-partum haemorrhage: >1000 ml (6%, -0% [-1%, +1%]).CONCLUSIONS: During the first COVID-19 lockdown in the Netherlands, a substantial increase in homebirths was seen. There was no evidence for changed available maternal outcomes, suggesting that a maternity care system with a strong midwife-led primary care system may flexibly and safely adapt to ext

Published
2024

16. Using non-randomized trials to assess the clinical benefit of systemic anti-cancer treatments:Viable or not?

Author

Xander, N. S.H., Leeneman, B., Dingemans, A. M.C., Fiets, W. E., de Jong, W. K., Uyl, N. E.M., Wymenga, A. N.M., Reyners, A. K.L., Uyl-de Groot, C. A., Xander, N. S.H., Leeneman, B., Dingemans, A. M.C., Fiets, W. E., de Jong, W. K., Uyl, N. E.M., Wymenga, A. N.M., Reyners, A. K.L., and Uyl-de Groot, C. A.

Abstract

Background: The Dutch Committee for the Evaluation of Oncological Agents (cieBOM) assesses the clinical benefit of systemic anti-cancer treatments (SACTs). For SACTs tested in non-randomized trials (NRTs), cieBOM primarily utilizes response-related thresholds as assessment criteria. As sufficiency of NRT-based evidence for benefit assessments is questionable, this study investigated whether and how NRTs can be used to assess the clinical benefit of new SACTs initially appraised by cieBOM based on randomized controlled trials (RCTs). Methods: Using the RCTs underpinning cieBOM recommendations issued between 2015 and 2017, we searched for matching NRTs and applied the NRT-related assessment criteria by cieBOM to them. We then compared the assessment outcomes to the respective RCT-based cieBOM recommendations. Further, we investigated how the assessments would change when applying different response-related thresholds and adding a progression-free survival (PFS) threshold. Results: For 13 of the 37 eligible recommendations, a matching NRT was found. Two treatments were assessed positively and six negatively; five treatments were non-assessable. Two positive recommendations matched a positive NRT-based assessment; one matching negative assessment was found, and one treatment could not be assessed based on either trial results. Adding a > 6 months PFS threshold decreased the number of non-assessable NRTs (five to two). Conclusions: Limited publications and inconsistent data reporting hampered the viability of NRTs for clinical benefit assessments of SACTs beyond the scope of rare indications. Further, response-related assessment criteria alone might not fully grasp the clinical benefit of novel SACTs. NRT-based assessments should be considered with caution due to uncertainty of the trial results.

Published
2024

18. Preferences and willingness to pay for personalized nutrition interventions:Discrete choice experiments in Europe and the United States

Author

Galekop, M. M.J., Veldwijk, J., Uyl-de Groot, C. A., Redekop, W. K., Galekop, M. M.J., Veldwijk, J., Uyl-de Groot, C. A., and Redekop, W. K.

Abstract

This study gives insight into what intervention-related factors are crucial for using personalized nutrition (PN) interventions, as well as what the general population is willing to pay for PN. This was done by focusing on two different types of PN (i.e., PN advice and personalized meals) in two discrete choice experiments (DCEs). The DCEs were conducted in four European countries and the United States, including at least 500 respondents per country aged 18–65 years. Panel mixed multinomial logit models were used to evaluate the preferences. Results show that for both types of PN in all countries, the total expenditure on nutrition was the most crucial factor when choosing a PN intervention. The participation rate for specific hypothetical scenario's varied but was considered high overall (maximum 81 % for ‘PN advice’ and 87 % for ‘personalized meals’ in Spain). Moreover, highest willingness to pay estimates were found for six kilograms of weight loss. For example, Polish respondents were willing to spend an extra 25.78 euros per week for ‘personalized meals’ for a 4-month period to lose six kilograms. Our models showed preference heterogeneity between, but also within, the different countries. In conclusion, this study showed that people seem willing to pay for and participate in PN interventions. Since PN interventions may improve health outcomes, policymakers should consider subsidizing some of the costs, financially incentivizing PN interventions or introducing commitment lotteries to encourage uptake. More research is needed to study heterogeneity in preferences.

Published
2024

19. Applying a cost-based pricing model for innovative cancer treatments subject to indication expansion:A case study for pembrolizumab and daratumumab

Author

Heine, R. J.S.D., Thielen, F. W., Mathijssen, R. H.J., van Leeuwen, R. W.F., Franken, M. G., Uyl-de Groot, C. A., Heine, R. J.S.D., Thielen, F. W., Mathijssen, R. H.J., van Leeuwen, R. W.F., Franken, M. G., and Uyl-de Groot, C. A.

Abstract

BACKGROUND: Expanding the indication of already approved immuno-oncology drugs presents treatment opportunities for patients but also strains healthcare systems. Cost-based pricing models are discussed as a possibility for cost containment. This study focuses on two drugs, pembrolizumab (Keytruda) and daratumumab (Darzalex), to explore the potential effect of indication broadening on the estimated price when using the cost-based pricing (CBP) model proposed by Uyl-de Groot and Löwenberg (2018). METHODS: The model was used to calculate cumulative yearly prices, cumulative prices per indication, and non-cumulative indication-based prices using inputs such as research and development (R&D) costs, manufacturing costs, eligible patient population, and a profit margin. A deterministic stepwise analysis and scenario analysis were conducted to examine how sensitive the estimated price is to the different input assumptions. RESULTS: The yearly cumulative cost-based prices (CBPs) ranged from €52 to €885 for pembrolizumab per vial and €823 to €31,941 for daratumumab per vial. Prices were higher in initial years or indications due to smaller patient populations, decreased over time or after additional indications. Sensitivity analysis showed that the number of eligible patients had the most significant impact on the estimated price. In the scenario analysis the profit margin contributed most to a higher CBPs for both drugs. Lower estimates resulted from assumed lower R&D costs. DISCUSSION: The estimated CBPs are consistently lower than Dutch list prices for pembrolizumab (€2,861), mainly resulting from larger patient populations in registered indications. However, daratumumab's list prices fall within the range of modeled CBPs depending on the year or indication (€4,766). Both CBPs decrease over time or with additional indications. The number of eligible patients and initial R&D costs have the most significant influence on the CBPs. These findings contribute to t

Published
2024

20. In context geplaatst: de economische werkelijkheid als juridische realiteit.

Author

de Groot, C. and van Oostrum, C.H.A.

Abstract

Copyright of Maandblad voor Ondernemingsrecht is the property of Boom uitgevers Den Haag and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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21. Normering van private equity door de rechter: De Ondernemingskamer en de procureur-generaal bij de Hoge Raad over Catalpa.

Author

Geels, Z.E. and de Groot, C.

Abstract

Copyright of Onderneming en Financiering is the property of Boom uitgevers Den Haag and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2024
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36. Anisotropy of Magnetization Reversal and Magnetoresistance in Square Arrays of Permalloy Nano-Rings

Author

Goncharov, A. V., Zhukov, A. A., Metlushko, V. V., Bordignon, G., Fangohr, H., de Groot, C. H., Unguris, J., Uhlig, W. C., Karapetrov, G., Ilic, B., and de Groot, P. A. J.

Subjects
Condensed Matter - Materials Science, Condensed Matter - Mesoscale and Nanoscale Physics
Abstract

Magnetization reversal mechanisms and impact of magnetization direction are studied in square arrays of interconnected circular permalloy nanorings using MOKE, local imaging, numerical simulations and transport techniques.

Published
2006
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39. Metamaterial-based smart and flexible Optical Solar Reflectors

Author

Gaspari, M, primary, Mengali, S, additional, Simeoni, M, additional, Urbani, A, additional, Muskens, O L, additional, Sun, K, additional, Zeimpekis, I, additional, de Groot, C H, additional, Bialy, A, additional, Czolkos, I, additional, Kildebro, L, additional, Alpat, B, additional, Bartolini, G, additional, Jamalipour, M, additional, Frolec, J, additional, Kralik, T, additional, Tessarin, F, additional, Gottero, M, additional, and Schillaci, T, additional

Published
2023
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48. The need for appropriate language in the debate on medicalisation of pregnancy

Author

Cluver, C, de Groot, C, Mol, BW, Murphy, KE, Norman, JE, Pacagnella, R, Palmer, K, Poon, LC, Rolnik, DL, Spong, CY, Stock, SJ, Thangaratinam, S, Tong, S, Verhoeven, C, Vuong, LN, Walker, SP, Xiaohua, L, Cluver, C, de Groot, C, Mol, BW, Murphy, KE, Norman, JE, Pacagnella, R, Palmer, K, Poon, LC, Rolnik, DL, Spong, CY, Stock, SJ, Thangaratinam, S, Tong, S, Verhoeven, C, Vuong, LN, Walker, SP, and Xiaohua, L

Published
2023

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