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Your search keyword '"De Gennaro, Nicolò"' showing total 24 results
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24 results on '"De Gennaro, Nicolò"'

1. Real life experience on the use of Remdesivir in patients admitted to COVID-19 in two referral Italian hospital: a propensity score matched analysis

Author

Veronese, Nicola, Di Gennaro, Francesco, Frallonardo, Luisa, Ciriminna, Stefano, Papagni, Roberta, Carruba, Luca, Agnello, Diletta, De Iaco, Giuseppina, De Gennaro, Nicolò, Di Franco, Giuseppina, Naro, Liliana, Brindicci, Gaetano, Rizzo, Angelo, Bavaro, Davide Fiore, Garlisi, Maria Chiara, Santoro, Carmen Rita, Signorile, Fabio, Balena, Flavia, Mansueto, Pasquale, Milano, Eugenio, Giannitrapani, Lydia, Fiordelisi, Deborah, Mariani, Michele Fabiano, Procopio, Andrea, Lattanzio, Rossana, Licata, Anna, Vernuccio, Laura, Amodeo, Simona, Guido, Giacomo, Segala, Francesco Vladimiro, Barbagallo, Mario, and Saracino, Annalisa

Published
2024
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2. Stigma and mental health among people living with HIV across the COVID-19 pandemic: a cross-sectional study

Author

Di Gennaro, Francesco, Papagni, Roberta, Segala, Francesco Vladimiro, Pellegrino, Carmen, Panico, Gianfranco Giorgio, Frallonardo, Luisa, Diella, Lucia, Belati, Alessandra, Santoro, Carmen Rita, Brindicci, Gaetano, Balena, Flavia, Bavaro, Davide Fiore, Montalbò, Domenico, Guido, Giacomo, Calluso, Lina, Di Tullio, Marilisa, Sgambati, Margherita, Fiordelisi, Deborah, De Gennaro, Nicolò, and Saracino, Annalisa

Published
2024
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3. Cefiderocol Versus Colistin for the Treatment of Carbapenem-Resistant Acinetobacter baumannii Complex Bloodstream Infections: A Retrospective, Propensity-Score Adjusted, Monocentric Cohort Study

Author

Bavaro, Davide Fiore, Papagni, Roberta, Belati, Alessandra, Diella, Lucia, De Luca, Antonio, Brindicci, Gaetano, De Gennaro, Nicolò, Di Gennaro, Francesco, Romanelli, Federica, Stolfa, Stefania, Ronga, Luigi, Mosca, Adriana, Pomarico, Francesco, Dell’Aera, Maria, Stufano, Monica, Dalfino, Lidia, Grasso, Salvatore, and Saracino, Annalisa

Published
2023
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4. Pittsburgh Sleep Quality Index (PSQI) Changes in Virologically Suppressed People Living with HIVSwitching to Long-Acting Cabotegravir and Rilpivirine.

Author

De Gennaro, Nicolò, Poliseno, Mariacristina, Dargenio, Angelo, Balena, Flavia, Fiordelisi, Deborah, Spada, Vito, Romita, Greta, Guido, Giacomo, Di Gennaro, Francesco, Bruno, Giuseppe, Purgatorio, Mariantonietta, Buccoliero, Giovanni Battista, and Saracino, Annalisa

Subjects
SLEEP quality, SLEEP latency, SLEEP interruptions, HIV-positive persons, ANTIRETROVIRAL agents
Abstract

Background: Limited evidence is available about sleep quality changes associated with the use of Cabotegravir (CAB), a new, long-acting (LA) antiretroviral (ARV) drug belonging to the class of Integrase Strand Transfer Inhibitors (INSTIs). Methods: Pittsburgh Sleep Quality Index (PSQI) was calculated in 53 people living with HIV (PLWH) under the care of the outpatient services of two Italian Infectious Diseases Centers in Apuliabefore (M0) and seven months after (M7) the switch to LA CAB. Global scores and relative subitems were compared using paired sample tests. The same analysis was repeated in subgroups of PLWH switching from INSTIs-, Dolutegravir-(DTG), and Bictegravir (BIC)-based regimens. Results: A significant reduction was reported in global mean (±StandardDeviation, SD) PSQI at M7 compared to M0 (4 (±3) vs. 3 (±2), p = 0.01), particularly in the areas of sleep latency and sleep disturbances. The improvement was also significant in PLWH already on INSTIs- (from median 3 to 2 points, p = 0.02) and DTG-based (from median 4 to 2, p = 0.01) ARV regimens, but not among those who switched from BIC-based regimens. Conclusions: PLWH reported improved sleep quality after switching from ARV treatment to LA CAB. Further studies are needed to give deeper insights into this phenomenon. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Intravenous Fosfomycin as Adjunctive Therapy for Gram-Negative Bacteria Bloodstream Infections: A Propensity Score Adjusted Retrospective Cohort Study

Author

Belati, Alessandra, Diella, Lucia, Bavaro, Davide Fiore, De Santis, Laura, Cotugno, Sergio, De Gennaro, Nicolò, Brindicci, Gaetano, Maggiore, Maria Elena, Indraccolo, Francesca, Di Gennaro, Francesco, Ronga, Luigi, Mosca, Adriana, Stufano, Monica, Dalfino, Lidia, Grasso, Salvatore, and Saracino, Annalisa

Published
2024
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7. Real Life Experience on the Use of Remdesivir in Patients Admitted to Covid-19 in Two Referral Italian Hospital: a Propensity Score Matched Analysis

Author

Veronese, Nicola, primary, Gennaro, Francesco Di, additional, Frallonardo, Luisa, additional, Ciriminna, Stefano, additional, Papagni, Roberta, additional, Carruba, Luca, additional, Agnello, Diletta, additional, De Iaco, Giuseppina, additional, De Gennaro, Nicolò, additional, Franco, Giuseppina Di, additional, Naro, Liliana, additional, Brindicci, Gaetano, additional, Rizzo, Angelo, additional, Bavaro, Davide Fiore, additional, Garlisi, Maria Chiara, additional, Santoro, Carmen Rita, additional, Signorile, Fabio, additional, Balena, Flavia, additional, Mansueto, Pasquale, additional, Milano, Eugenio, additional, Giannitrapani, Lydia, additional, Fiordelisi, Deborah, additional, Mariani, Michele Fabiano, additional, Procopio, Andrea, additional, Lattanzio, Rossana, additional, Licata, Anna, additional, Vernuccio, Laura, additional, Amodeo, Simona, additional, Guido, Giacomo, additional, Segala, Francesco Vladimiro, additional, Barbagallo, Mario, additional, and Saracino, Annalisa, additional

Published
2023
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10. Impact of a Pro-Active Infectious Disease Consultation on the Management of a Multidrug-Resistant Organisms Outbreak in a COVID-19 Hospital: A Three-Months Quasi-Experimental Study

Author

Bavaro, Davide Fiore, primary, De Gennaro, Nicolò, additional, Belati, Alessandra, additional, Diella, Lucia, additional, Papagni, Roberta, additional, Frallonardo, Luisa, additional, Camporeale, Michele, additional, Guido, Giacomo, additional, Pellegrino, Carmen, additional, Marrone, Maricla, additional, Dell’Erba, Alessandro, additional, Gesualdo, Loreto, additional, Brienza, Nicola, additional, Grasso, Salvatore, additional, Columbo, Giuseppe, additional, Moschetta, Antonio, additional, Carpagnano, Giovanna Elisiana, additional, Daleno, Antonio, additional, Minicucci, Anna Maria, additional, Migliore, Giovanni, additional, and Saracino, Annalisa, additional

Published
2023
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11. Prompt and Appropriate Antimicrobial Therapy Improves Outcomes of NDM-Producing and KPC-Producing Klebsiella pneumoniae Bloodstream Infections in Patients Hospitalized for COVID-19: A Comparative Retrospective Case-Series

Author

Bavaro, Davide Fiore, primary, Belati, Alessandra, additional, Diella, Lucia, additional, Poli, Melita Anna, additional, Calamo, Angela, additional, De Candia, Giovanna, additional, Altamura, Maurantonio, additional, Spadavecchia, Felicia Anna, additional, Brindicci, Gaetano, additional, De Gennaro, Nicolò, additional, Di Gennaro, Francesco, additional, Saracino, Annalisa, additional, and Carbonara, Sergio, additional

Published
2022
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12. Impact of a Multistep Bundles Intervention in the Management and Outcome of Gram-Negative Bloodstream Infections: A Single-Center “Proof-of-Concept” Study

Author

Bavaro, Davide Fiore, primary, Diella, Lucia, additional, Belati, Alessandra, additional, De Gennaro, Nicolò, additional, Fiordelisi, Deborah, additional, Papagni, Roberta, additional, Guido, Giacomo, additional, De Vita, Elda, additional, Frallonardo, Luisa, additional, Camporeale, Michele, additional, Pellegrino, Carmen, additional, Denicolò, Sofia, additional, Ranieri, Enrica, additional, Mariani, Michele Fabiano, additional, Brindicci, Gaetano, additional, Ronga, Luigi, additional, Di Gennaro, Francesco, additional, Mosca, Adriana, additional, and Saracino, Annalisa, additional

Published
2022
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13. Multidisciplinary Approach in the Treatment of Descending Necrotizing Mediastinitis: Twenty-Year Single-Center Experience

Author

De Palma, Angela, primary, Cantatore, Mirko Girolamo, additional, Di Gennaro, Francesco, additional, Signore, Francesca, additional, Panza, Teodora, additional, Brascia, Debora, additional, De Iaco, Giulia, additional, Sampietro, Doroty, additional, Quercia, Rosatea, additional, Genualdo, Marcella, additional, Pizzuto, Ondina, additional, Garofalo, Giuseppe, additional, Signorile, Fabio, additional, Bavaro, Davide Fiore, additional, Brindicci, Gaetano, additional, De Gennaro, Nicolò, additional, Saracino, Annalisa, additional, Quaranta, Nicola Antonio Adolfo, additional, Favia, Gianfranco, additional, and Marulli, Giuseppe, additional

Published
2022
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16. Cefiderocol Versus Colistin for the Treatment of Carbapenem-Resistant Acinetobacter baumanniiComplex Bloodstream Infections: A Retrospective, Propensity-Score Adjusted, Monocentric Cohort Study

Author

Bavaro, Davide Fiore, Papagni, Roberta, Belati, Alessandra, Diella, Lucia, De Luca, Antonio, Brindicci, Gaetano, De Gennaro, Nicolò, Di Gennaro, Francesco, Romanelli, Federica, Stolfa, Stefania, Ronga, Luigi, Mosca, Adriana, Pomarico, Francesco, Dell’Aera, Maria, Stufano, Monica, Dalfino, Lidia, Grasso, Salvatore, and Saracino, Annalisa

Abstract

Introduction: Bloodstream infections (BSI) caused by carbapenem-resistant Acinetobacter baumannii(CRAB) are associated with high mortality with limited treatment. The aim of this study is to compare effectiveness and safety of colistin-based versus cefiderocol-based therapies for CRAB-BSI. Methods: This is a retrospective observational study enrolling patients with monomicrobial CRAB-BSIs treated with colistin or cefiderocol from 1 January 2020, to 31 December 2022. The 30-day all-cause mortality rate was the primary outcome. A Cox regression analysis was performed to identify factors independently associated with mortality. A propensity score analysis using inverse probability of treatment weighting (IPTW) was also performed. Results: Overall 118 patients were enrolled, 75 (63%) and 43 (37%) treated with colistin- and cefiderocol-based regimens. The median (q1–q3) age was 70 (62–79) years; 70 (59%) patients were men. Conclusions: Cefiderocol may be a valuable treatment option for CRAB-BSI, especially in the current context of limited treatment options.

Published
2023
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22. Clusterizzazione di comorbidità e multimorbidità tra le persone che vivono con HIV, e rischio di interazione malattia-malattia: report preliminare

Author

R. Santoro, Carmen, primary, Ricci, Elena, primary, De Gennaro, Nicolò, primary, Bellacosa, Chiara, primary, Nofri, Marco, primary, Schiaroli, Elisabetta, primary, Orofino, Giancarlo, primary, Menzaghi, Barbara, primary, Squillace, Nicola, primary, Di Biagio, Antonio, primary, Francisci, Daniela, primary, Vichi, Francesca, primary, and Molteni, Chiara, primary

Published
2018
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24. Loading dose plus continuous/extended infusion versus intermittent bolus of β-lactams for the treatment of Gram-negative bacteria bloodstream infections: a propensity score-adjusted retrospective cohort study.

Author

Bavaro DF, Belati A, Diella L, Frallonardo L, Guido G, Papagni R, Pellegrino C, Brindicci G, De Gennaro N, Di Gennaro F, Denicolò S, Ronga L, Mosca A, Pomarico F, Dell'Aera M, Stufano M, Dalfino L, Grasso S, and Saracino A

Subjects
Humans, beta-Lactams therapeutic use, Anti-Bacterial Agents therapeutic use, Retrospective Studies, Propensity Score, Gram-Negative Bacteria, Gram-Negative Bacterial Infections drug therapy, Sepsis drug therapy, Bacteremia drug therapy, Bacteremia microbiology
Abstract

Background: Optimal β-lactam dosing for the treatment of Gram-negative bacteria bloodstream infections (GNB-BSIs) remains a debated issue. Herein, the efficacy and safety of a loading dose (LD) followed by extended/continuous infusion (EI/CI) versus intermittent bolus (IB) of these drugs for the treatment of GNB-BSIs was evaluated., Methods: This is a retrospective observational study enrolling patients with GNB-BSIs treated with β-lactams from 1 October 2020 to 31 March 2022. The 30 day infection-related mortality rate was assessed with Cox regression, while mortality risk reduction was evaluated by an inverse probability of treatment weighting regression adjustment (IPTW-RA) model., Results: Overall, 224 patients were enrolled: 140 and 84 in the IB and EI/CI groups, respectively. β-Lactam regimens were chosen according to pathogen antibiogram, clinical judgement and current guidelines. Interestingly, the LD + EI/CI regimen was associated with a significant lower mortality rate (17% versus 32%, P = 0.011). Similarly, β-lactam LD + EI/CI was significantly associated with a reduced risk of mortality at multivariable Cox regression [adjusted HR (aHR) = 0.46; 95%CI = 0.22-0.98; P = 0.046]. Finally, the IPTW-RA (adjusted for multiple covariates) was performed, showing a significant risk reduction in the overall population [-14% (95% CI = -23% to -5%)]; at the subgroup restricted analysis, a significant risk reduction (>15%) was observed in the case of GNB-BSI in severely immunocompromised patients (P = 0.003), for SOFA score > 6 (P = 0.014) and in septic shock (P = 0.011)., Conclusions: The use of LD + EI/CI of β-lactams in patients with a GNB-BSI may be associated with reduced mortality; also in patients with severe presentation of infection or with additional risk factors, such as immunodepression., (© The Author(s) 2023. Published by Oxford University Press on behalf of British Society for Antimicrobial Chemotherapy. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)

Published
2023
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