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1. Patient engagement in hematopoietic stem cell transplantation and cell therapy: a survey by the EBMT patient engagement task force & transplantation complications working party

Author

Schoemans, Hélène, Burns, Linda J., Liptrott, Sarah J., Murray, John, Kenyon, Michelle, Barata, Anna, Bolaños, Natacha, Scholl, Isabelle, Hamilton, Betty, Phelan, Rachel, Buchbinder, David, Penack, Olaf, Moiseev, Ivan, Boreland, William, Peczynski, Christophe, De Geest, Sabina, Sureda, Anna, Snowden, John A., Shaw, Bronwen, Peric, Zinaida, and Kroeger, Nicolaus

Published
2024
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2. Factors Associated With Physical Inactivity of Recipients of a Kidney Transplant: Results From the ADHERE BRAZIL Multicenter Study

Author

Sertorio, Emiliana S., Colugnati, Fernando A.B., Denhaerynck, Kris, de Smet, Stefan, Medina, Jose O.P., Reboredo, Maycon M., de Geest, Sabina, and Sanders-Pinheiro, Helady

Subjects
Kidneys -- Transplantation, Exercise -- Health aspects, Chronic kidney failure -- Care and treatment -- Patient outcomes, Health
Abstract

Objective. Physical activity is recommended for recipients of a kidney transplant. However, ADHERE BRAZIL study found a high prevalence (69%) of physical inactivity in Brazilian recipients of a kidney transplant. To tackle this behavior, a broad analysis of barriers is needed. This study aimed to identify factors (patient and transplant center levels) associated with physical inactivity among recipients of a kidney transplant. Methods. This was a subproject of the ADHERE BRAZIL study, a cross-sectional, multicenter study of 1105 recipients of a kidney transplant from 20 kidney transplant centers. Using a multistage sampling method, patients were proportionally and randomly selected. Applying the Brief Physical Activity Assessment questionnaire, patients were classified as physically active ([greater than or equal to]150 min/wk) or physically inactive ( Results. At the patient level, physical inactivity was associated with smoking (odds ratio = 2.43; 95% CI = 0.97-6.06), obesity (odds ratio = 1.79; 95% CI = 1.26-2.55), peripheral vascular disease (odds ratio = 3.18; 95% CI = 1.20-8.42), >3 posttransplant hospitalizations (odds ratio = 1.58; 95% CI = 1.17-2.13), family income of >1 reference salary ($248.28 per month; odds ratio = 0.66; 95% CI = 0.48-0.90), and student status (odds ratio = 0.58; 95% CI = 0.37-0.92). At the center level, the correlates were having exercise physiologists in the clinical team (odds ratio = 0.54; 95% CI = 0.46-0.64) and being monitored in a teaching hospital (undergraduate students) (odds ratio = 1.47; 95% CI = 1.01 -2.13). Conclusions. This study identified factors associated with physical inactivity after kidney transplantation that may guide future multilevel behavioral change interventions for physical activity. Impact. In a multicenter sample of recipients of a kidney transplant with a prevalence of physical inactivity of 69%, we found associations between this behavior and patient- and center-level factors. At the patient level, the chance of physical inactivity was positively associated with smoking, obesity, and patient morbidity (peripheral vascular disease and hospitalization events after kidney transplantation). Conversely, a high family income and a student status negatively correlated with physical inactivity. At the center level, the presence of a dedicated professional to motivate physical activity resulted in a reduced chance of physical inactivity. A broad knowledge of barriers associated with physical inactivity can allow us to identify patients at a high risk of not adhering to the recommended levels of physical activity. Keywords: Clinical Decision-Making, Kidney Transplant, Multicenter Study, Multilevel Analysis, Physical Inactivity, Introduction For patients with stage 5 chronic kidney disease (CKD), kidney transplantation promotes increased survival and improves quality of life, in addition to being more cost-effective than other renal replacement [...]

Published
2024
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5. Surgical site infections after kidney transplantation are independently associated with graft loss

Author

Amico, Patrizia, Aubert, John-David, Banz, Vanessa, Beckmann, Sonja, Beldi, Guido, Berger, Christoph, Berishvili, Ekaterine, Berzigotti, Annalisa, Binet, Isabelle, Bochud, Pierre-Yves, Branca, Sanda, Bucher, Heiner, Catana, Emmanuelle, Cairoli, Anne, Chalandon, Yves, De Geest, Sabina, De Rougemont, Olivier, De Seigneux, Sophie, Dickenmann, Michael, Dreifuss, Joëlle Lynn, Duchosal, Michel, Fehr, Thomas, Ferrari-Lacraz, Sylvie, Garzoni, Christian, Golshayan, Déla, Goossens, Nicolas, Haidar, Fadi, Halter, Jörg, Heim, Dominik, Hess, Christoph, Hillinger, Sven, Hirsch, Hans H., Hirt, Patricia, Hoessly, Linard, Hofbauer, Günther, Huynh-Do, Uyen, Immer, Franz, Koller, Michael, Laesser, Bettina, Lamoth, Frédéric, Lehmann, Roger, Leichtle, Alexander, Manuel, Oriol, Marti, Hans-Peter, Martinelli, Michele, McLin, Valérie, Mellac, Katell, Merçay, Aurélia, Mettler, Karin, Mueller, Nicolas J., Müller-Arndt, Ulrike, Müllhaupt, Beat, Nägeli, Mirjam, Oldani, Graziano, Pascual, Manuel, Passweg, Jakob, Pazeller, Rosemarie, Posfay-Barbe, Klara, Rick, Juliane, Rosselet, Anne, Rossi, Simona, Rothlin, Silvia, Ruschitzka, Frank, Schachtner, Thomas, Schaub, Stefan, Scherrer, Alexandra, Schnyder, Aurelia, Schuurmans, Macé, Schwab, Simon, Sengstag, Thierry, Simonetta, Federico, Stampf, Susanne, Steiger, Jürg, Stirnimann, Guido, Stürzinger, Ueli, Van Delden, Christian, Venetz, Jean-Pierre, Villard, Jean, Vionnet, Julien, Wick, Madeleine, Wilhelm, Markus, Yerly, Patrick, Schreiber, Peter W., Hoessly, Linard D., Boggian, Katia, Neofytos, Dionysios, van Delden, Christian, Egli, Adrian, Hirzel, Cédric, Schmied, Bruno, Guerke, Lorenz, Matter, Maurice, de Rougemont, Olivier, Bonani, Marco, Sidler, Daniel, and Kuster, Stefan P.

Published
2024
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10. The MELD upgrade exception: a successful strategy to optimize access to liver transplantation for patients with high waiting list mortality

Author

Amico, Patrizia, Axel, Andres, Aubert, John-David, Banz, Vanessa, Sonja, Beckmann, Beldi, Guido, Benden, Christian, Berger, Christoph, Binet, Isabelle, Bochud, Pierre-Yves, Branca, Sanda, Bucher, Heiner, Carrel, Thierry, Catana, Emmanuelle, Chalandon, Yves, de Geest, Sabina, de Rougemont, Olivier, Dickenmann, Michael, Dreifuss, Joëlle L., Duchosal, Michel, Fehr, Thomas, Ferrari-Lacraz, Sylvie, Garzoni, Christian, Soccal, Paola G., Gaudet, Christophe, Giostra, Emiliano, Golshayan, Déla, Hadaya, Karine, Halter, Jörg, Hauri, Dimitri, Heim, Dominik, Hess, Christoph, Hillinger, Sven, Hirsch, Hans, Hirt, Patricia, Hofbauer, Günther, Huynh-Do, Uyen, Immer, Franz, Koller, Michael, Laesser, Bettina, Lang, Brian, Lehmann, Roger, Leichtle, Alexander, Lovis, Christian, Manuel, Oriol, Marti, Hans-Peter, Martin, Pierre Y., Martinelli, Michele, Mellac, Katell, Merçay, Aurélia, Mettler, Karin, Meylan, Pascal, Mueller, Nicolas, Müller, Antonia, Müller, Thomas, Müller-Arndt, Ulrike, Müllhaupt, Beat, Nägeli, Mirjam, Pascual, Manuel, Posfay-Barbe, Klara, Rick, Juliane, Rosselet, Anne, Rossi, Simona, Rothlin, Silvia, Ruschitzka, Frank, Schanz, Urs, Schaub, Stefan, Schnyder, Aurelia, Schuurmans, Macé, Simonetta, Federico, Staufer, Katharina, Stampf, Susanne, Steiger, Jürg, Stirniman, Guido, Stürzinger, Ueli, Toso, Christian, Van Delden, Christian, Venetz, Jean-Pierre, Villard, Jean, Vionnet, Julien, Wick, Madeleine, Wilhlem, Markus, Yerly, Patrick, Dirchwolf, Melisa, Becchetti, Chiara, Gschwend, Sarah G., Dutkowski, Philipp, Beyeler, Franziska, Schropp, Jonas, and Dufour, Jean-François

Published
2022
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19. Characteristics and Activities of Nurses in Expanded Roles Employed in Swiss Nursing Homes: A Cross‐Sectional Study.

Author

Saladino, Christian, Favez, Lauriane, Serdaly, Christine, Ausserhofer, Dietmar, De Geest, Sabina, and Zúñiga, Franziska

Subjects
NURSES, SUPERVISION of employees, CROSS-sectional method, EVIDENCE-based nursing, OCCUPATIONAL roles, INTERPROFESSIONAL relations, SECONDARY analysis, CRONBACH'S alpha, DATA analysis, RESEARCH funding, STATISTICAL sampling, QUESTIONNAIRES, LEADERSHIP, KRUSKAL-Wallis Test, NURSING, DESCRIPTIVE statistics, NURSE practitioners, NURSING care facilities, ETHICAL decision making, JOB descriptions, RESEARCH, CONCEPTUAL structures, NURSING practice, PHYSICIAN practice patterns, STATISTICS, PHYSICIANS, FACTOR analysis, DATA analysis software, EDUCATIONAL attainment, MEDICAL referrals
Abstract

Background: As the number of nursing home residents with multiple healthcare needs grows, the demand for nursing expertise increases. The implementation of new care models involving nurses with expanded roles is crucial for ensuring quality care in nursing homes. Objectives: To investigate the characteristics and activities of nurses employed in nursing homes in expanded roles and the factors associated with variation in the activities performed. Methods: This multicentre cross‐sectional survey in Switzerland collected data from a convenience sample of 118 nursing homes between September 2018 and October 2019. From a subsample of 62 nursing homes, we analysed the characteristics and activities of 104 nurses in expanded roles. Associations between the activities performed and the educational background of the nurses in expanded roles, their direct supervisors' positions and the presence of physicians in the nursing homes were examined. Results: Most Registered Nurses in expanded roles were diploma educated (48%), with fewer having a bachelor's (35%) or master's degree (17%). Overall, direct clinical practice and guidance and coaching activities were conducted monthly to weekly; consultation, evidence‐based practice, collaboration and ethical decision‐making activities were conducted monthly. We saw variations where a higher educational background was associated with more frequent evidence‐based practice activities (z = 3.47, p < 0.001), and if direct supervisors were ward managers, nurses in expanded roles worked more frequently below their scope of practice (z = 4.10, p < 0.001). Conclusion: This is the first study to use Hamric's integrative Advanced Practice Nursing model to examine the activities of nurses in expanded roles in nursing homes. We found considerable variation in their activities, where nursing homes seem to adapt their roles to their educational background and the local context. Implications for Practice: Our findings show the importance of clarifying role expectations for Registered Nurses in expanded roles, allowing them to practice at the top of the licence to meet residents' complex healthcare needs. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Assessing and managing frailty in advanced heart failure: An International Society for Heart and Lung Transplantation consensus statement

Author

Denfeld, Quin E., primary, Jha, Sunita R., additional, Fung, Erik, additional, Jaarsma, Tiny, additional, Maurer, Mathew S., additional, Reeves, Gordon R., additional, Afilalo, Jonathan, additional, Beerli, Nadine, additional, Bellumkonda, Lavanya, additional, De Geest, Sabina, additional, Gorodeski, Eiran Z., additional, Joyce, Emer, additional, Kobashigawa, Jon, additional, Mauthner, Oliver, additional, McDonagh, Julee, additional, Uchmanowicz, Izabella, additional, Dickson, Victoria Vaughan, additional, Lindenfeld, JoAnn, additional, and Macdonald, Peter, additional

Published
2024
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27. Contributors

Author

Alshihiri, Saad, primary, Amatya, Kaushalendra, additional, Argyropoulos, Christos P., additional, Berman, Nathaniel, additional, Centron, Patricia, additional, Chilcot, Joseph, additional, Christian Cornelius, Matthew, additional, Cohen, Scott D., additional, Cukor, Daniel, additional, De Geest, Sabina M., additional, Denhaerynck, Kris, additional, Dobbels, Fabienne, additional, Engel, Kristy L., additional, Farrington, Ken, additional, Foy, Capri G., additional, Graham Ford, C., additional, Gray, Nicholas A., additional, Griva, Konstadina, additional, Hooper, Stephen R., additional, Jhamb, Manisha, additional, Johansen, Kirsten L., additional, Kimmel, Paul L., additional, Kuntz, Kristin K., additional, Levy, Norman B., additional, Lew, Susie Q., additional, Mehrotra, Rajnish, additional, Moxey-Mims, Marva M., additional, Myaskovsky, Larissa, additional, Nataatmadja, Melissa S., additional, Newman, Stanton P., additional, Norton, Jenna M., additional, Parker Gregg, L., additional, Quinn, Davin K., additional, Ribaut, Janette, additional, Roumelioti, Maria-Eleni, additional, Steel, Jennifer, additional, Susan Hedayati, S., additional, Unruh, Mark L., additional, Varma, Elly, additional, Wang, Connie J., additional, Weinman, John, additional, Wetmore, James B., additional, and Won, Alice, additional

Published
2021
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30. Trust in the Transplant Team Associated With the Level of Chronic Illness Management—A Secondary Data Analysis of the International BRIGHT Study.

Author

Mielke, Juliane, Cajita, Maan Isabella, Denhaerynck, Kris, Valenta, Sabine, Dobbels, Fabienne, Russell, Cynthia L., and De Geest, Sabina

Subjects
TRUST, SECONDARY analysis, CHRONIC diseases, HEART transplant recipients, HEART transplantation
Abstract

A trustful relationship between transplant patients and their transplant team (interpersonal trust) is essential in order to achieve positive health outcomes and behaviors. We aimed to 1) explore variability of trust in transplant teams; 2) explore the association between the level of chronic illness management and trust; 3) investigate the relationship of trust on behavioral outcomes. A secondary data analysis of the BRIGHT study (ID: NCT01608477; https://clinicaltrials.gov/ct2/show/NCT01608477?id=NCT01608477&rank=1) was conducted, including multicenter data from 36 heart transplant centers from 11 countries across four different continents. A total of 1,397 heart transplant recipients and 100 clinicians were enrolled. Trust significantly varied among the transplant centers. Higher levels of chronic illness management were significantly associated with greater trust in the transplant team (patients: AOR= 1.85, 95% CI = 1. 47–2.33, p < 0.001; clinicians: AOR = 1.35, 95% CI = 1.07–1.71, p = 0.012). Consultation time significantly moderated the relationship between chronic illness management levels and trust only when clinicians spent ≥30 min with patients. Trust was significantly associated with better diet adherence (OR = 1.34, 95%CI = 1.01–1.77, p = 0.040). Findings indicate the relevance of trust and chronic illness management in the transplant ecosystem to achieve improved transplant outcomes. Thus, further investment in reengineering of transplant follow-up toward chronic illness management, and sufficient time for consultations is required. [ABSTRACT FROM AUTHOR]

Published
2024
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33. The 2018 ISHLT/APM/AST/ICCAC/STSW Recommendations for the Psychosocial Evaluation of Adult Cardiothoracic Transplant Candidates and Candidates for Long-term Mechanical Circulatory Support

Author

Dew, Mary Amanda, DiMartini, Andrea F., Dobbels, Fabienne, Grady, Kathleen L., Jowsey-Gregoire, Sheila G., Kaan, Annemarie, Kendall, Kay, Young, Quincy-Robyn, Abbey, Susan E., Butt, Zeeshan, Crone, Catherine C., De Geest, Sabina, Doligalski, Christina T., Kugler, Christiane, McDonald, Laurie, Ohler, Linda, Painter, Liz, Petty, Michael G., Robson, Desiree, Schlöglhofer, Thomas, Schneekloth, Terry D., Singer, Jonathan P., Smith, Patrick J., Spaderna, Heike, Teuteberg, Jeffrey J., Yusen, Roger D., and Zimbrean, Paula C.

Published
2018
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40. Embedding implementation science in the research pipeline

Author

Zullig, Leah L, Drake, Connor, Check, Devon K, Brunkert, Thekla, Deschodt, Mieke, Olson, Melvin (Skip), and De Geest, Sabina

Abstract

Clinical and health services researchers seek to discover effective programs, practices, and interventions to improve people’s health. The current paradigm for evidence generation is incremental and misaligned to translate evidence-based discoveries into real-world settings. This persistent challenge are “valleys of death” that represent missed opportunities and preventable missteps to actually use scientific advancements in real-world clinical settings where they can improve health and well-being (De Geest S, Zúñiga F, Brunkert T et al. Powering Swiss health care for the future: implementation science to bridge “the valley of death”. 2020;150:w20323). Only one in seven of evidence-based interventions is ever implemented. It is after an average of 17 years. We propose embedding the principles of implementation science throughout the research pipeline, from discovery to adoption, to efficiently translate discoveries into real-world contexts (Balas EA, Boren SA. Managing clinical knowledge for health care improvement. 2000;9:65–70). We outline implications for capacity building, including composition of the research team, study design, and competencies that could bolster the value proposition of implementation science. We describe a research paradigm that recognizes scientists’ responsibility to ensure their discoveries be translated into real-world settings.Integrating implementation science principles earlier in the research pipeline can support getting the best care to the people that need it sooner.Most innovative research is not used in clinical care settings. When it is, it takes a very long time to get into the real world. This means that patients may not get the best care possible to improve their health. The research community has tools that can help design innovative research in ways that it could work in clinical care settings and tools to help that happen faster, so that clinical care teams and patients can use innovative research. This is called implementation science. We outline why it is important to use implementation science ideas and teams earlier and how we can support infrastructure to do so.

Published
2024
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41. Heart transplant centers with multidisciplinary team show a higher level of chronic illness management – Findings from the International BRIGHT Study

Author

Crespo-Leiro, Maria G., Cupples, Sandra, De Simone, Paolo, Groenewoud, Albert, Kugler, Christiane, Ohler, Linda, Van Cleemput, Johan, Poncelet, Alain Jean, Sebbag, Laurent, Michel, Magali, Bernard, Andrée, Doesch, Andreas, Livi, Ugolino, Manfredini, Valentina, Brossa-Loidi, Vicens, Segovia-Cubero, Javier, Almenar-Bonet, Luis, Segura Saint-Gerons, Carmen, Mohacsi, Paul, Horvath, Eva, Riotto, Cheryl, Parry, Gareth, Firouzi, Ashi, Kozuszko, Stella, Haddad, Haissam, Kaan, Annemarie, Fisher, Grant, Miller, Tara, Flattery, Maureen, Ludrosky, Kristin, Coleman, Bernice, Trammell, Jacqueline, St. Clair, Katherine, Kao, Andrew, Molina, Maria, Canales, Karyn Ryan, de Almeida, Samira Scalso, Ayoub, Andrea Cotait, Barone, Fernanda, Harkess, Michelle, Maddicks-Law, Joanne, Cajita, Maan Isabella, Baumgartner, Eva, Berben, Lut, Denhaerynck, Kris, Helmy, Remon, Schönfeld, Sandra, Berger, Gabriele, Vetter, Christine, Dobbels, Fabienne, Russell, Cynthia L., and De Geest, Sabina

Published
2017
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45. Accuracy and usability of the eGVHD app in assessing the severity of graft-versus-host disease at the 2017 EBMT annual congress

Author

Schoemans, Helene M., Goris, Kathy, Van Durm, Raf, Vanbrabant, Koen, De Geest, Sabina, Maertens, Johan, Wolff, Daniel, Greinix, Hildegard, Ruutu, Tapani, Pavletic, Steve Z., Im, Annie, Lee, Stephanie J., Basak, Grzegorz W., Duarte, Rafael F., Dobbels, Fabienne, and on behalf of the Complications and Quality of Life Working Party of the EBMT

Published
2018
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46. The use of nurse‐led care intervention to improve self‐care abilities subsequently decreasing readmission in multimorbid hospitalized patients: A quasi‐experimental study in a real‐world setting

Author

Faessler, Lukas, primary, Kofler, Sabine, additional, Wenke‐Zobler, Juliane, additional, Brunner, Corinne, additional, Schäfer‐Keller, Petra, additional, De Geest, Sabina, additional, Schubert, Maria, additional, Regez, Katharina, additional, Schuetz, Philipp, additional, Mueller, Beat, additional, and Conca, Antoinette, additional

Published
2023
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50. Context-specific adaptation of an eHealth-facilitated, integrated care model and tailoring its implementation strategies. A mixed-methods study as a part of the SMILe implementation science project

Author

Valenta, Sabine, Ribaut, Janette, Leppla, Lynn, Mielke, Juliane, Teynor, Alexandra, Koehly, Katharina, Gerull, Sabine, Grossmann, Florian, Witzig-Brändli, Verena, De Geest, Sabina, and on behalf of the SMILe study team

Subjects
implementation science, advanced practice nursing, allogeneic stem cell transplantation, eHealth, mixed-methods research design, adaptation, stakeholder participation, integrated care
Abstract

BACKGROUND: Contextually adapting complex interventions and tailoring their implementation strategies is key to a successful and sustainable implementation. While reporting guidelines for adaptations and tailoring exist, less is known about how to conduct context-specific adaptations of complex health care interventions. AIMS: To describe in methodological terms how the merging of contextual analysis results (step 1) with stakeholder involvement, and considering overarching regulations (step 2) informed our adaptation of an Integrated Care Model (ICM) for SteM cell transplantatIon faciLitated by eHealth (SMILe) and the tailoring of its implementation strategies (step 3). METHODS: Step 1: We used a mixed-methods design at University Hospital Basel, guided by the Basel Approach for coNtextual ANAlysis (BANANA). Step 2: Adaptations of the SMILe-ICM and tailoring of implementation strategies were discussed with an interdisciplinary team (n = 28) by considering setting specific and higher-level regulatory scenarios. Usability tests were conducted with patients (n = 5) and clinicians (n = 4). Step 3: Adaptations were conducted by merging our results from steps 1 and 2 using the Framework for Reporting Adaptations and Modifications-Enhanced (FRAME). We tailored implementation strategies according to the Expert Recommendations for Implementing Change (ERIC) compilation. RESULTS: Step 1: Current clinical practice was mostly acute-care-driven. Patients and clinicians valued eHealth-facilitated ICMs to support trustful patient-clinician relationships and the fitting of eHealth components to context-specific needs. Step 2: Based on information from project group meetings, adaptations were necessary on the organizational level (e.g., delivery of self-management information). Regulations informed the tailoring of SMILe-ICM`s visit timepoints and content; data protection management was adapted following Swiss regulations; and steering group meetings supported infrastructure access. The usability tests informed further adaptation of technology components. Step 3: Following FRAME and ERIC, SMILe-ICM and its implementation strategies were contextually adapted and tailored to setting-specific needs. DISCUSSION: This study provides a context-driven methodological approach on how to conduct intervention adaptation including the tailoring of its implementation strategies. The revealed meso-, and macro-level differences of the contextual analysis suggest a more targeted approach to enable an in-depth adaptation process. A theory-guided adaptation phase is an important first step and should be sufficiently incorporated and budgeted in implementation science projects. ispartof: Front Health Serv vol:2 pages:977564- ispartof: location:Switzerland status: Published online

Published
2023

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