Search

Your search keyword '"De France I"' showing total 2 results
Start Over Author "De France I"
2 results on '"De France I"'

1. Pyrazole-3/5-carboxylic acids from 3/5-trifluoromethyl NH-pyrazoles

Author

Sandrine Guillou, Mikhail S. Ermolenko, Yves L. Janin, Institut de Chimie des Substances Naturelles (ICSN), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Chimie organique (CNR - UMR3523), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris], Region Ile de France I 06-222/R I 09-1739/R, Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Chimie organique (CNRS - UMR3523), and Institut Pasteur [Paris] (IP)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Trifluoromethyl, 010405 organic chemistry, Negishi coupling, [CHIM.ORGA]Chemical Sciences/Organic chemistry, Organic Chemistry, Pyrazole, 010402 general chemistry, 01 natural sciences, Biochemistry, 0104 chemical sciences, chemistry.chemical_compound, Hydrolysis, chemistry, Drug Discovery, Organic chemistry, Derivative (chemistry), Building blocks 3/5-Trifluoromethylpyrazoles Pyrazole-3/5-carboxylic acids Cross-coupling Palladium catalysis
Abstract

International audience; We report here the transformation of 3/5-trifluoromethylpyrazoles derivative into the corresponding NH-pyrazole-3/5-carboxylic acids. Moreover, from 4- or 5-iodinated-3/5-trifluoromethylpyrazoles building blocks and the use of SuzukieMiyaura or Negishi reactions followed by the trifluoromethyl hydrolysis, we illustrate short and original accesses to many series of NH-pyrazole-3/5-carboxylic acids otherwise difficult to prepare.

Published
2013
Full Text
View/download PDF

2. [Ultrasonographic and pathological correlation in a fetal intracranial cyst: a case of "diencephalo-synapsis"].

Author

De France I, Saada P, Jouannic JM, Tantau J, Martinovic J, and Encha-Razavi F

Subjects
Abnormalities, Multiple etiology, Abortion, Therapeutic, Brain Diseases etiology, Cysts etiology, Female, Fetal Diseases etiology, Genetic Counseling, Genotype, Humans, Phenotype, Pregnancy, Pregnancy Trimester, Second, Reproducibility of Results, Abnormalities, Multiple diagnostic imaging, Abnormalities, Multiple pathology, Agenesis of Corpus Callosum, Biopsy standards, Brain Diseases diagnostic imaging, Brain Diseases pathology, Choroid Plexus, Cysts diagnostic imaging, Cysts pathology, Fetal Diseases diagnostic imaging, Fetal Diseases pathology, Prenatal Diagnosis standards, Third Ventricle abnormalities, Ultrasonography, Prenatal standards
Abstract

Brain imaging now provides exquisite images of the central nervous system (CNS) enabling identification of CNS malformations early during pregnancy. However, pathogenical evaluation, necessary for genetic counselling, requires a detailed neuropathological analysis. Brain imaging of a female fetus at 27 weeks gestation disclosed a paramedial cystic formation, considered to be a porencephalic lesion. Neuropathological correlation after pregnancy termination disclosed partial atresia of the third ventricle, responsible for lateral ventricle dilatation and corpus callosum lamination. Atresia of the third ventricle, that we suggest could be called "diencephalo-synapsis", is a rare CNS malformation due to an unknown cause. Further neuropathological studies and phenotype-genotype correlations are necessary for the delineation of the entity and the comprehension of its cause and pathogenesis.

Published
2002

Catalog

Books, media, physical & digital resources
See catalog results