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496 results on '"De Felice, Fernanda G."'

1. Sex differences in mitochondrial free-carnitine levels in subjects at-risk and with Alzheimer’s disease in two independent study cohorts

Author

Bigio, Benedetta, Lima-Filho, Ricardo A. S., Barnhill, Olivia, Sudo, Felipe K., Drummond, Claudia, Assunção, Naima, Vanderborght, Bart, Beasley, James, Young, Sarah, Korman, Aryeh, Jones, Drew R., Sultzer, David L., Ferreira, Sergio T., Mattos, Paulo, Head, Elizabeth, Tovar-Moll, Fernanda, De Felice, Fernanda G., Lourenco, Mychael V., and Nasca, Carla

Published
2025
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3. Changes in social environment impact primate gut microbiota composition

Author

Pearce, Colleen S., Bukovsky, Danielle, Douchant, Katya, Katoch, Abhay, Greenlaw, Jill, Gale, Daniel J., Nashed, Joseph Y., Brien, Don, Kuhlmeier, Valerie A., Sabbagh, Mark A., Blohm, Gunnar, De Felice, Fernanda G., Pare, Martin, Cook, Douglas J., Scott, Stephen H., Munoz, Douglas P., Sjaarda, Calvin P., Tusche, Anita, Sheth, Prameet M., Winterborn, Andrew, Boehnke, Susan, and Gallivan, Jason P.

Published
2024
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5. Changes in neuroinflammatory biomarkers correlate with disease severity and neuroimaging alterations in patients with COVID-19 neurological complications

Author

Barros-Aragão, Fernanda G.Q., Pinto, Talita P., Carregari, Victor C., Rezende, Nathane B.S., Pinheiro, Thaís L., Reis-de-Oliveira, Guilherme, Cabral-Castro, Mauro J., Queiroz, Daniel C., Fonseca, Paula L.C., Gonçalves, Alessandro L., de Freitas, Gabriel R., Sudo, Felipe K., Mattos, Paulo, Bozza, Fernando A., Rodrigues, Erika C., Aguiar, Renato S., Rodrigues, Rosana S., Brandão, Carlos O., Souza, Andrea S., Martins-de-Souza, Daniel, De Felice, Fernanda G., and Tovar-Moll, Fernanda

Published
2024
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7. Cognitive, behavioral, neuroimaging and inflammatory biomarkers after hospitalization for COVID-19 in Brazil

Author

Kenji Sudo, Felipe, Pinto, Talita P., G. Q. Barros-Aragão, Fernanda, Bramati, Ivanei, Marins, Theo F., Monteiro, Marina, Meireles, Fernanda, Soares, Rejane, Erthal, Pilar, Calil, Victor, Assuncao, Naima, Oliveira, Natalia, Bondarovsky, Joana, Lima, Camila, Chagas, Beatriz, Batista, Alana, Lins, Julia, Pinheiro, Thaís L., Mendonca, Felippe, Silveira de Souza, Andrea, Rodrigues, Fernanda C., de Freitas, Gabriel R., Kurtz, Pedro, Mattos, Paulo, Rodrigues, Erika C., De Felice, Fernanda G., and Tovar-Moll, Fernanda

Published
2024
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8. Dementia in Latin America: Paving the way toward a regional action plan.

Author

Parra, Mario Alfredo, Baez, Sandra, Sedeño, Lucas, Gonzalez Campo, Cecilia, Santamaría-García, Hernando, Aprahamian, Ivan, Bertolucci, Paulo Hf, Bustin, Julian, Camargos Bicalho, Maria Aparecida, Cano-Gutierrez, Carlos, Caramelli, Paulo, Chaves, Marcia LF, Cogram, Patricia, Beber, Bárbara Costa, Court, Felipe A, de Souza, Leonardo Cruz, Custodio, Nilton, Damian, Andres, de la Cruz, Myriam, Diehl Rodriguez, Roberta, Brucki, Sonia Maria Dozzi, Fajersztajn, Lais, Farías, Gonzalo A, De Felice, Fernanda G, Ferrari, Raffaele, de Oliveira, Fabricio Ferreira, Ferreira, Sergio T, Ferretti, Ceres, Figueredo Balthazar, Marcio Luiz, Ferreira Frota, Norberto Anizio, Fuentes, Patricio, García, Adolfo M, Garcia, Patricia J, de Gobbi Porto, Fábio Henrique, Duque Peñailillo, Lissette, Engler, Henry Willy, Maier, Irene, Mata, Ignacio F, Gonzalez-Billault, Christian, Lopez, Oscar L, Morelli, Laura, Nitrini, Ricardo, Quiroz, Yakeel T, Guerrero Barragan, Alejandra, Huepe, David, Pio, Fabricio Joao, Suemoto, Claudia Kimie, Kochhann, Renata, Kochen, Silvia, Kumfor, Fiona, Lanata, Serggio, Miller, Bruce, Mansur, Leticia Lessa, Hosogi, Mirna Lie, Lillo, Patricia, Llibre Guerra, Jorge, Lira, David, Lopera, Francisco, Comas, Adelina, Avila-Funes, José Alberto, Sosa, Ana Luisa, Ramos, Claudia, Resende, Elisa de Paula França, Snyder, Heather M, Tarnanas, Ioannis, Yokoyama, Jenifer, Llibre, Juan, Cardona, Juan Felipe, Possin, Kate, Kosik, Kenneth S, Montesinos, Rosa, Moguilner, Sebastian, Solis, Patricia Cristina Lourdes, Ferretti-Rebustini, Renata Eloah de Lucena, Ramirez, Jeronimo Martin, Matallana, Diana, Mbakile-Mahlanza, Lingani, Marques Ton, Alyne Mendonça, Tavares, Ronnielly Melo, Miotto, Eliane C, Muniz-Terrera, Graciela, Muñoz-Nevárez, Luis Arnoldo, Orozco, David, Okada de Oliveira, Maira, Piguet, Olivier, Pintado Caipa, Maritza, Piña Escudero, Stefanie Danielle, Schilling, Lucas Porcello, Rodrigues Palmeira, André Luiz, Yassuda, Mônica Sanches, Santacruz-Escudero, Jose Manuel, Serafim, Rodrigo Bernardo, Smid, Jerusa, Slachevsky, Andrea, Serrano, Cecilia, Soto-Añari, Marcio, Takada, Leonel Tadao, Grinberg, Lea Tenenholz, Teixeira, Antonio Lucio, and Barbosa, Maira Tonidandel

Subjects
Latin America, biomarkers, clinical trials, dementia, epidemiology, evidence-based recommendations, genetics, knowledge to action framework, networking and translational research, nonpharmacological interventions, Dementia, Clinical Research, Brain Disorders, Aging, Acquired Cognitive Impairment, Prevention, Neurological, Clinical Sciences, Neurosciences, Geriatrics
Abstract

Across Latin American and Caribbean countries (LACs), the fight against dementia faces pressing challenges, such as heterogeneity, diversity, political instability, and socioeconomic disparities. These can be addressed more effectively in a collaborative setting that fosters open exchange of knowledge. In this work, the Latin American and Caribbean Consortium on Dementia (LAC-CD) proposes an agenda for integration to deliver a Knowledge to Action Framework (KtAF). First, we summarize evidence-based strategies (epidemiology, genetics, biomarkers, clinical trials, nonpharmacological interventions, networking, and translational research) and align them to current global strategies to translate regional knowledge into transformative actions. Then we characterize key sources of complexity (genetic isolates, admixture in populations, environmental factors, and barriers to effective interventions), map them to the above challenges, and provide the basic mosaics of knowledge toward a KtAF. Finally, we describe strategies supporting the knowledge creation stage that underpins the translational impact of KtAF.

Published
2021

9. AAV-mediated neuronal expression of an scFv antibody selective for Aβ oligomers protects synapses and rescues memory in Alzheimer models

Author

Selles, Maria Clara, Fortuna, Juliana T.S., Cercato, Magali C., Santos, Luis Eduardo, Domett, Luciana, Bitencourt, Andre L.B., Carraro, Mariane Favero, Souza, Amanda S., Janickova, Helena, Azevedo, Caroline Vieira, Campos, Henrique Correia, de Souza, Jorge M., Alves-Leon, Soniza, Prado, Vania F., Prado, Marco A.M., Epstein, Alberto L., Salvetti, Anna, Longo, Beatriz Monteiro, Arancio, Ottavio, Klein, William L., Sebollela, Adriano, De Felice, Fernanda G., Jerusalinsky, Diana A., and Ferreira, Sergio T.

Published
2023
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10. The impact of SARS‐CoV‐2 in dementia across Latin America: A call for an urgent regional plan and coordinated response

Author

Ibanez, Agustin, Santamaria‐Garcia, Hernando, Barragan, Alejandra Guerrero, Kornhuber, Alexander, Ton, Alyne Mendonca Marques, Slachevsky, Andrea, Teixeira, Antonio Lucio, Meza, Beatriz Marcela Mar, Serrano, Cecilia M, Cano, Carlos, Gonzalez, Carolina Arias, Gonzalez‐Billault, Christian, Butler, Christopher, Bustin, Julian, Duran‐Aniotz, Claudia, Acosta, Daisy, Matallana, Diana L, Acosta‐Alvear, Diego, Trépel, Dominic, De Paula França Resende, Elisa, Oliveira, Fabricio Ferreira, Ibanez, Francisco, De Felice, Fernanda G, Navarrete, Gorka, Tarnanas, Ioannis, Meier, Irene B, Smid, Jerusa, Llibre‐Guerra, Jorge, Llibre‐Rodriguez, Juan J, Fajersztajn, Laís, Takada, Leonel Tadao, Duque, Lissette, de Oliveira, Maira Okada, Bicalho, Maria Aparecida Camargos, Behrens, María Isabel, Pintado‐Caipa, Maritza, Parra, Mario, Wilson, Maxwell Z, De La Cruz Puebla, Myriam, Custodio, Nilton, Santibanez, Rodrigo, Serafim, Rodrigo Bernardo, Tavares, Ronnielly Melo, Escudero, Stefanie Danielle Piña, Rodriguez, Tomas Leon, Dawson, Walter, Miller, Bruce L, and Kosik, Kenneth S

Subjects
Emerging Infectious Diseases, Brain Disorders, Prevention, Acquired Cognitive Impairment, Dementia, Neurological, Reduced Inequalities, coronavirus, dementia, health system, Latin American and Caribbean countries, SARS-CoV-2, SARS‐CoV‐2
Abstract

The SARS-CoV-2 global pandemic will disproportionately impact countries with weak economies and vulnerable populations including people with dementia. Latin American and Caribbean countries (LACs) are burdened with unstable economic development, fragile health systems, massive economic disparities, and a high prevalence of dementia. Here, we underscore the selective impact of SARS-CoV-2 on dementia among LACs, the specific strain on health systems devoted to dementia, and the subsequent effect of increasing inequalities among those with dementia in the region. Implementation of best practices for mitigation and containment faces particularly steep challenges in LACs. Based upon our consideration of these issues, we urgently call for a coordinated action plan, including the development of inexpensive mass testing and multilevel regional coordination for dementia care and related actions. Brain health diplomacy should lead to a shared and escalated response across the region, coordinating leadership, and triangulation between governments and international multilateral networks.

Published
2020

15. Type I Hsp40s/DnaJs aggregates exhibit features reminiscent of amyloidogenic structures.

Author

Tiroli‐Cepeda, Ana O., Linhares, Leonardo A., Aragão, Annelize Z. B., de Jesus, Jemmyson R., Wasilewska‐Sampaio, Ana P., De Felice, Fernanda G., Ferreira, Sérgio T., Borges, Júlio C., Cyr, Douglas M., and Ramos, Carlos H. I.

Subjects
HEAT shock proteins, MOLECULAR chaperones, DIFFRACTION patterns, CIRCULAR dichroism, CYTOTOXINS
Abstract

A rise in temperature triggers a structural change in the human Type I 40 kDa heat shock protein (Hsp40/DnaJ), known as DNAJA1. This change leads to a less compact structure, characterized by an increased presence of solvent‐exposed hydrophobic patches and β‐sheet‐rich regions. This transformation is validated by circular dichroism, thioflavin T binding, and Bis‐ANS assays. The formation of this β‐sheet‐rich conformation, which is amplified in the absence of zinc, leads to protein aggregation. This aggregation is induced not only by high temperatures but also by low ionic strength and high protein concentration. The aggregated conformation exhibits characteristics of an amyloidogenic structure, including a distinctive X‐ray diffraction pattern, seeding competence (which stimulates the formation of amyloid‐like aggregates), cytotoxicity, resistance to SDS, and fibril formation. Interestingly, the yeast Type I Ydj1 also tends to adopt a similar β‐sheet‐rich structure under comparable conditions, whereas Type II Hsp40s, whether human or from yeast, do not. Moreover, Ydj1 aggregates were found to be cytotoxic. Studies using DNAJA1‐ and Ydj1‐deleted mutants suggest that the zinc‐finger region plays a crucial role in amyloid formation. Our discovery of amyloid aggregation in a C‐terminal deletion mutant of DNAJA1, which resembles a spliced homolog expressed in the testis, implies that Type I Hsp40 co‐chaperones may generate amyloidogenic species in vivo. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Palmitate Is Increased in the Cerebrospinal Fluid of Humans with Obesity and Induces Memory Impairment in Mice via Pro-inflammatory TNF-α

Author

Melo, Helen M., Seixas da Silva, Gisele da S., Sant’Ana, Marcella Ramos, Teixeira, Camila Vieira Ligo, Clarke, Julia R., Miya Coreixas, Vivian S., de Melo, Bruno C., Fortuna, Juliana T.S., Forny-Germano, Leticia, Ledo, José Henrique, Oliveira, Maíra S., Figueiredo, Claudia P., Pardossi-Piquard, Raphaelle, Checler, Frédéric, Delgado-García, José María, Gruart, Agnès, Velloso, Licio A., Balthazar, Marcio L.F., Cintra, Dennys E., Ferreira, Sergio T., and De Felice, Fernanda G.

Published
2020
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25. Alzheimer‐associated Aβ oligomers impact the central nervous system to induce peripheral metabolic deregulation

Author

Clarke, Julia R, Lyra e Silva, Natalia M, Figueiredo, Claudia P, Frozza, Rudimar L, Ledo, Jose H, Beckman, Danielle, Katashima, Carlos K, Razolli, Daniela, Carvalho, Bruno M, Frazão, Renata, Silveira, Marina A, Ribeiro, Felipe C, Bomfim, Theresa R, Neves, Fernanda S, Klein, William L, Medeiros, Rodrigo, LaFerla, Frank M, Carvalheira, Jose B, Saad, Mario J, Munoz, Douglas P, Velloso, Licio A, Ferreira, Sergio T, and De Felice, Fernanda G

Subjects
Alzheimer's Disease, Neurosciences, Prevention, Aging, Diabetes, Dementia, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Nutrition, Neurodegenerative, Acquired Cognitive Impairment, Brain Disorders, 2.1 Biological and endogenous factors, Aetiology, Neurological, Metabolic and endocrine, Alzheimer Disease, Amyloid beta-Peptides, Animals, Female, Glucose, Humans, Hypothalamus, Macaca, Male, Mice, Mice, Inbred C57BL, NF-kappa B, Neurons, Oligonucleotides, Peripheral Nerves, Rats, Signal Transduction, Tumor Necrosis Factor-alpha, Alzheimer's disease, ER stress, hypothalamus, inflammation, insulin resistance, Biological Sciences, Medical and Health Sciences
Abstract

Alzheimer's disease (AD) is associated with peripheral metabolic disorders. Clinical/epidemiological data indicate increased risk of diabetes in AD patients. Here, we show that intracerebroventricular infusion of AD-associated Aβ oligomers (AβOs) in mice triggered peripheral glucose intolerance, a phenomenon further verified in two transgenic mouse models of AD. Systemically injected AβOs failed to induce glucose intolerance, suggesting AβOs target brain regions involved in peripheral metabolic control. Accordingly, we show that AβOs affected hypothalamic neurons in culture, inducing eukaryotic translation initiation factor 2α phosphorylation (eIF2α-P). AβOs further induced eIF2α-P and activated pro-inflammatory IKKβ/NF-κB signaling in the hypothalamus of mice and macaques. AβOs failed to trigger peripheral glucose intolerance in tumor necrosis factor-α (TNF-α) receptor 1 knockout mice. Pharmacological inhibition of brain inflammation and endoplasmic reticulum stress prevented glucose intolerance in mice, indicating that AβOs act via a central route to affect peripheral glucose homeostasis. While the hypothalamus has been largely ignored in the AD field, our findings indicate that AβOs affect this brain region and reveal novel shared molecular mechanisms between hypothalamic dysfunction in metabolic disorders and AD.

Published
2015

26. The ketamine metabolite (2R,6R)‐hydroxynorketamine rescues hippocampal mRNA translation, synaptic plasticity and memory in mouse models of Alzheimer's disease.

Author

Ribeiro, Felipe C., Cozachenco, Danielle, Argyrousi, Elentina K., Staniszewski, Agnieszka, Wiebe, Shane, Calixtro, Joao D., Soares‐Neto, Rubens, Al‐Chami, Aycheh, Sayegh, Fatema El, Bermudez, Sara, Arsenault, Emily, Cossenza, Marcelo, Lacaille, Jean‐Claude, Nader, Karim, Sun, Hongyu, De Felice, Fernanda G., Lourenco, Mychael V., Arancio, Ottavio, Aguilar‐Valles, Argel, and Sonenberg, Nahum

Abstract

INTRODUCTION: Impaired brain protein synthesis, synaptic plasticity, and memory are major hallmarks of Alzheimer's disease (AD). The ketamine metabolite (2R,6R)‐hydroxynorketamine (HNK) has been shown to modulate protein synthesis, but its effects on memory in AD models remain elusive. METHODS: We investigated the effects of HNK on hippocampal protein synthesis, long‐term potentiation (LTP), and memory in AD mouse models. RESULTS: HNK activated extracellular signal‐regulated kinase 1/2 (ERK1/2), mechanistic target of rapamycin (mTOR), and p70S6 kinase 1 (S6K1)/ribosomal protein S6 signaling pathways. Treatment with HNK rescued hippocampal LTP and memory deficits in amyloid‐β oligomers (AβO)‐infused mice in an ERK1/2‐dependent manner. Treatment with HNK further corrected aberrant transcription, LTP and memory in aged APP/PS1 mice. DISCUSSION: Our findings demonstrate that HNK induces signaling and transcriptional responses that correct synaptic and memory deficits in AD mice. These results raise the prospect that HNK could serve as a therapeutic approach in AD. Highlights: The ketamine metabolite HNK activates hippocampal ERK/mTOR/S6 signaling pathways.HNK corrects hippocampal synaptic and memory defects in two mouse models of AD.Rescue of synaptic and memory impairments by HNK depends on ERK signaling.HNK corrects aberrant transcriptional signatures in APP/PS1 mice. [ABSTRACT FROM AUTHOR]

Published
2024
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27. Correction of mTORC1‐mediated brain protein synthesis rescues memory in mouse models of Alzheimer’s disease

Author

Cozachenco, Danielle, primary, Ribeiro, Felipe C., additional, Argyrousi, Elentina K., additional, Staniszewski, Agnieszka, additional, De Felice, Fernanda G., additional, Lourenco, Mychael V., additional, Arancio, Ottavio, additional, Aguilar‐Valles, Argel, additional, Sonenberg, Nahum, additional, and Ferreira, Sergio T., additional

Published
2023
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28. Synaptic proteasome is inhibited in Alzheimer’s disease models and is associated with memory impairment in mice

Author

Ribeiro, Felipe C., primary, Ferreira, Danielle Cozachenco, additional, Fortuna, Juliana, additional, de Freitas, Guilherme B., additional, Souza, Jorge M, additional, Alves‐Leon, Soniza, additional, Leite, Renata Elaine Paraizo, additional, Suemoto, Claudia Kimie, additional, Grinberg, Lea T., additional, De Felice, Fernanda G., additional, Lourenco, Mychael V., additional, and Ferreira, Sergio T., additional

Published
2023
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30. Free-floating adult human brain-derived slice cultures as a model to study the neuronal impact of Alzheimer’s disease-associated Aβ oligomers

Author

Mendes, Niele D., Fernandes, Artur, Almeida, Glaucia M., Santos, Luis E., Selles, Maria Clara, Lyra e Silva, N.M., Machado, Carla M., Horta-Júnior, José A.C., Louzada, Paulo R., De Felice, Fernanda G., Alves-Leon, Soniza, Marcondes, Jorge, Assirati, João Alberto, Jr., Matias, Caio M., Klein, William L., Garcia-Cairasco, Norberto, Ferreira, Sergio T., Neder, Luciano, and Sebollela, Adriano

Published
2018
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31. Pro-inflammatory interleukin-6 signaling links cognitive impairments and peripheral metabolic alterations in Alzheimer’s disease

Author

Lyra e Silva, Natalia M., Gonçalves, Rafaella A., Pascoal, Tharick A., Lima-Filho, Ricardo A. S., Resende, Elisa de Paula França, Vieira, Erica L. M., Teixeira, Antonio L., de Souza, Leonardo C., Peny, Julyanna A., Fortuna, Juliana T. S., Furigo, Isadora C., Hashiguchi, Debora, Miya-Coreixas, Vivian S., Clarke, Julia R., Abisambra, Jose F., Longo, Beatriz M., Donato, Jr., Jose, Fraser, Paul E., Rosa-Neto, Pedro, Caramelli, Paulo, Ferreira, Sergio T., and De Felice, Fernanda G.

Published
2021
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35. Mesenchymal stem cells and cell-derived extracellular vesicles protect hippocampal neurons from oxidative stress and synapse damage induced by amyloid-β oligomers

Author

de Godoy, Mariana A., Saraiva, Leonardo M., de Carvalho, Luiza R.P., Vasconcelos-dos-Santos, Andreia, Beiral, Hellen J.V., Ramos, Alane Bernardo, Silva, Livian R. de Paula, Leal, Renata B., Monteiro, Victor H.S., Braga, Carolina V., de Araujo-Silva, Carlla A., Sinis, Leandro C., Bodart-Santos, Victor, Kasai-Brunswick, Tais Hanae, Alcantara, Carolina de Lima, Lima, Ana Paula C.A., da Cunha-e Silva, Narcisa L., Galina, Antonio, Vieyra, Adalberto, De Felice, Fernanda G., Mendez-Otero, Rosalia, and Ferreira, Sergio T.

Published
2018
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36. Cognitive, behavioral, neuroimaging and inflammatory biomarkers after hospitalization for covid-19 in Brazil

Author

Kenji Sudo, Felipe, primary, Pinto, Talita P., additional, G. Q. Barros-Aragao, Fernanda, additional, Bramati, Ivanei, additional, Marins, Theo F., additional, Monteiro, Marina, additional, Meireles, Fernanda, additional, Soares, Rejane, additional, Erthal, Pilar, additional, Calil, Victor, additional, Assuncao, Naima, additional, Oliveira, Natalia, additional, Bondarovsky, Joana, additional, Lima, Camila, additional, Chagas, Beatriz, additional, Batista, Alana, additional, Lins, Julia, additional, Mendonca, Felippe, additional, Silveira de Souza, Andrea, additional, Rodrigues, Fernanda C., additional, de Freitas, Gabriel R., additional, Kurtz, Pedro, additional, Mattos, Paulo, additional, Rodrigues, Erika C., additional, De Felice, Fernanda G., additional, and Tovar-Moll, Fernanda, additional

Published
2023
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37. Brain infusion of α-synuclein oligomers induces motor and non-motor Parkinson’s disease-like symptoms in mice

Author

Fortuna, Juliana T.S., Gralle, Matthias, Beckman, Danielle, Neves, Fernanda S., Diniz, Luan P., Frost, Paula S., Barros-Aragão, Fernanda, Santos, Luís E., Gonçalves, Rafaella A., Romão, Luciana, Zamberlan, Daniele C., Soares, Felix A.A., Braga, Carolina, Foguel, Debora, Gomes, Flávia C.A., De Felice, Fernanda G., Ferreira, Sergio T., Clarke, Julia R., and Figueiredo, Cláudia P.

Published
2017
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40. Interaction of amyloid-β (Aβ) oligomers with neurexin 2α and neuroligin 1 mediates synapse damage and memory loss in mice

Author

Brito-Moreira, Jordano, Lourenco, Mychael V., Oliveira, Mauricio M., Ribeiro, Felipe C., Ledo, José Henrique, Diniz, Luan P., Vital, Juliana F.S., Magdesian, Margaret H., Melo, Helen M., Barros-Aragão, Fernanda, de Souza, Jorge M., Alves-Leon, Soniza V., Gomes, Flavia C.A., Clarke, Julia R., Figueiredo, Cláudia P., De Felice, Fernanda G., and Ferreira, Sergio T.

Published
2017
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41. Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models

Author

Lourenco, Mychael V., Frozza, Rudimar L., de Freitas, Guilherme B., Zhang, Hong, Kincheski, Grasielle C., Ribeiro, Felipe C., Gonçalves, Rafaella A., Clarke, Julia R., Beckman, Danielle, Staniszewski, Agnieszka, Berman, Hanna, Guerra, Lorena A., Forny-Germano, Letícia, Meier, Shelby, Wilcock, Donna M., de Souza, Jorge M., Alves-Leon, Soniza, Prado, Vania F., Prado, Marco A. M., Abisambra, Jose F., Tovar-Moll, Fernanda, Mattos, Paulo, Arancio, Ottavio, Ferreira, Sergio T., and De Felice, Fernanda G.

Published
2019
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42. Brain STAT5 signaling modulates learning and memory formation

Author

Furigo, Isadora C., Melo, Helen M., Lyra e Silva, Natalia M., Ramos-Lobo, Angela M., Teixeira, Pryscila D. S., Buonfiglio, Daniella C., Wasinski, Frederick, Lima, Eliana R., Higuti, Eliza, Peroni, Cibele N., Bartolini, Paolo, Soares, Carlos R. J., Metzger, Martin, de Felice, Fernanda G., and Donato, Jr., Jose

Published
2018
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43. Stimulation of mRNA translation rescues hippocampal synaptic plasticity and memory in mouse models of Alzheimer’s disease

Author

Ribeiro, Felipe C., primary, Cozachenco, Danielle, additional, Argyrousi, Elentina K., additional, Staniszewski, Agnieszka, additional, Wiebe, Shane, additional, Calixtro, Joao D., additional, Soares-Neto, Rubens, additional, Al-Chami, Aycheh, additional, El Sayegh, Fatema, additional, Bermudez, Sara, additional, Arsenault, Emily, additional, Cossenza, Marcelo, additional, Lacaille, Jean-Claude, additional, Nader, Karim, additional, Sun, Hongyu, additional, De Felice, Fernanda G., additional, Lourenco, Mychael V., additional, Arancio, Ottavio, additional, Aguilar-Valles, Argel, additional, Sonenberg, Nahum, additional, and Ferreira, Sergio T., additional

Published
2023
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44. Changes in neurodegeneration and amyloid biomarkers in patients with COVID-19 neurological complications and Alzheimer’s disease

Author

Barros-Aragão, Fernanda G. Q., primary, Pinto, Talita P., additional, Carregari, Victor C., additional, Rezende, Nathane B. S., additional, Pinheiro, Thaís L., additional, Reis-de-Oliveira, Guilherme, additional, Queiroz, Daniel C., additional, Fonseca, Paula L. C., additional, Gonçalves, Alessandro L., additional, Cabral-Castro, Mauro J., additional, Freitas, Gabriel R., additional, Vanderborgh, Bart, additional, Sudo, Felipe K., additional, Mattos, Paulo, additional, Bozza, Fernando A., additional, Rodrigues, Erika C., additional, Rodrigues, Rosana S., additional, Brandão, Carlos O., additional, Souza, Andrea S., additional, Aguiar, Renato S., additional, Martins-de-Souza, Daniel, additional, De Felice, Fernanda G., additional, and Tovar-Moll, Fernanda F., additional

Published
2023
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47. Zika virus replicates in adult human brain tissue and impairs synapses and memory in mice

Author

Figueiredo, Claudia P., Barros-Aragão, Fernanda G. Q., Neris, Rômulo L. S., Frost, Paula S., Soares, Carolina, Souza, Isis N. O., Zeidler, Julianna D., Zamberlan, Daniele C., de Sousa, Virginia L., Souza, Amanda S., Guimarães, André Luis A., Bellio, Maria, Marcondes de Souza, Jorge, Alves-Leon, Soniza V., Neves, Gilda A., Paula-Neto, Heitor A., Castro, Newton G., De Felice, Fernanda G., Assunção-Miranda, Iranaia, Clarke, Julia R., Da Poian, Andrea T., and Ferreira, Sergio T.

Published
2019
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49. Alzheimer's disease brain‐derived extracellular vesicles reveal altered synapse‐related proteome and induce cognitive impairment in mice.

Author

Bodart‐Santos, Victor, Pinheiro, Lisandra S., da Silva‐Junior, Almir J., Froza, Rudimar L., Ahrens, Rosemary, Gonçalves, Rafaella A., Andrade, Mayara M., Chen, Yan, Alcantara, Carolina de Lima, Grinberg, Lea T., Leite, Renata E. P., Ferreira, Sergio T., Fraser, Paul E., and De Felice, Fernanda G.

Abstract

INTRODUCTION: Extracellular vesicles (EVs) have been implicated in the spread of neuropathology in Alzheimer's disease (AD), but their involvement in behavioral outcomes linked to AD remains to be determined. METHODS: EVs isolated from post mortem brain tissue from control, AD, or frontotemporal dementia (FTD) donors, as well as from APP/PS1 mice, were injected into the hippocampi of wild‐type (WT) or a humanized Tau mouse model (hTau/mTauKO). Memory tests were carried out. Differentially expressed proteins in EVs were assessed by proteomics. RESULTS: Both AD‐EVs and APP/PS1‐EVs trigger memory impairment in WT mice. We further demonstrate that AD‐EVs and FTD‐EVs carry Tau protein, present altered protein composition associated with synapse regulation and transmission, and trigger memory impairment in hTau/mTauKO mice. DISCUSSION: Results demonstrate that AD‐EVs and FTD‐EVs have negative impacts on memory in mice and suggest that, in addition to spreading pathology, EVs may contribute to memory impairment in AD and FTD. Highlights: Aβ was detected in EVs from post mortem AD brain tissue and APP/PS1 mice.Tau was enriched in EVs from post mortem AD, PSP and FTD brain tissue.AD‐derived EVs and APP/PS1‐EVs induce cognitive impairment in wild‐type (WT) mice.AD‐ and FTD‐derived EVs induce cognitive impairment in humanized Tau mice.Proteomics findings associate EVs with synapse dysregulation in tauopathies. [ABSTRACT FROM AUTHOR]

Published
2023
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50. Alteration in the number of neuronal and non-neuronal cells in mouse models of obesity

Author

Andrade, Mayara M, primary, Fernandes, Caroline, additional, Forny-Germano, Leticia, additional, Gonçalves, Rafaella A, additional, Gomes, Michelle, additional, Castro-Fonseca, Emily, additional, Ramos-Lobo, Angela M, additional, Tovar-Moll, Fernanda, additional, Andrade-Moraes, Carlos Humberto, additional, Donato, Jose, additional, and De Felice, Fernanda G, additional

Published
2023
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