86 results on '"De Dios, Y"'
Search Results
2. Sensorimotor Predictors of Post-Landing Functional Task Performance
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Wood, S. J, De Dios, Y. E, Peters, B. T, Beltran, N. E, Caldwell, E. E, Rosenberg, M. J, Koppelmans, V, Clark, T. K, Seidler, R. D, Oddsson, L, Theriot, C. A, Reschke, M. F, Feiveson, A. F, and Bloomberg, J. J
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Life Sciences (General) - Abstract
Spaceflight drives adaptive changes in healthy individuals appropriate for sensorimotor function in a microgravity environment. These changes are maladaptive for return to earth's gravity. The inter-individual variability of sensorimotor decrements is striking, although poorly understood. The goal of this study is to identify a set of behavioral, neuroimaging and genetic measures that can potentially be used to predict early performance following G-transitions such as return to Earth on a set of sensorimotor tasks. Astronauts are being recruited who previously participated in sensorimotor field tests and/or dynamic posturography (MedB) within R+1 days following long-duration spaceflight.
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- 2020
3. Daily Artificial Gravity is Associated with Greater Neural Efficiency during Sensorimotor Adaptation
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Tays, G.D., primary, Hupfeld, K.E., additional, McGregor, H.R., additional, Gadd, N.E., additional, Kofman, I. S., additional, De Dios, Y. E., additional, Mulder, E.R., additional, Bloomberg, J.J., additional, Mulavara, A.P., additional, Wood, S.J., additional, and Seidler, R. D., additional
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- 2022
- Full Text
- View/download PDF
4. Neural correlates of multi-day learning and savings in sensorimotor adaptation
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Ruitenberg, M. F. L., Koppelmans, V., De Dios, Y. E., Gadd, N. E., Wood, S. J., Reuter-Lorenz, P. A., Kofman, I., Bloomberg, J. J., Mulavara, A. P., and Seidler, R. D.
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- 2018
- Full Text
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5. Field Test: Results from the One Year Mission
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Reschke, M. F, Kozlovskaya, I. B, Kofman, I. S, Tomilovskaya, E. S, Cerisano, J. M, Rosenberg, M. J. F, Bloomberg, J. J, Stenger, M. B, Lee, S. M. C, Laurie, S. S, Rukavishnikov, I. V, Fomina, E. V, Wood, S. J, Mulavara, A. P, Feiveson, A. H, Fisher, E. A, Phillips, T, Ribeiro, C, Taylor, L. C, Miller, C. A, Gadd, N. E, Peters, B. T, Kitov, V. V, Lysova, N. Yu, Holden, K. L, and De Dios, Y
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Behavioral Sciences ,Aerospace Medicine - Abstract
The One Year Mission was designed to aid in determining the effect that extending the duration on orbit aboard the International Space Station (ISS) would have on a number of biological and physiological systems. Two crewmembers were selected to participate in this endeavor, one U.S. On-Orbit Segment (USOS) astronaut and one Russian cosmonaut. The Neuroscience and Cardiovascular and Vision Laboratories at the Johnson Space Center and the Sensory-Motor and Countermeasures Division within the Institute for Biomedical Problems were selected to investigate vestibular, sensorimotor and cardiovascular function with the two long-duration crewmembers using the established methodology developed for the Field Test (FT).
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- 2017
6. Behavioral, Brain Imaging, and Genomic Measures to Predict Functional Outcomes After Bed Rest and Spaceflight
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Mulavara, A, Peters, B, De Dios, Y, Gadd, N, Caldwell, E, Watson, C, Oddsson, L, Kreutzberg, G, Zanello, S, Clark, T, Waddington, G, Oman, C, Cohen, H, Wood, S, Seidler, R, Reschke, M, and Bloomberg, J
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Aerospace Medicine - Published
- 2017
7. Behavioral Assessment of Spaceflight Effects on Neurocognitive Performance: Extent and Longevity
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De Dios, Y. E, Kofman, I. S, Gadd, N. E, Kreutzberg, G. A, Peters, B. T, Taylor, L. C, Campbell, D. J, Wood, S. J, Bloomberg, J. J, Seidler, R. D, and Mulavara, A. P
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Aerospace Medicine ,Behavioral Sciences - Abstract
Exposure to the microgravity environment during spaceflight missions impacts crewmembers' sensorimotor function. Bock et al. [1] studied the cognitive demands of human sensorimotor performance and dual tasking during long duration missions and concluded that both stress and scarcity of cognitive resources required for sensorimotor adaptation may be responsible for these deficits during spaceflight. Therefore, in consideration of the health and performance of crewmembers in- and post-flight, we are conducting this study to investigate the effects of spaceflight on the extent, longevity and neural bases of sensorimotor, cognitive, and neural changes. The data presented will focus on the behavioral measures that were collected pre-, in- and post-flight including spatial cognition, processing speed, bimanual coordination, functional mobility, computerized dynamic posturography (CDP), and vibrotactile induced vestibular evoked myogenic potential (VEMP). To date, data were collected over the course of two pre-flight sessions and four post-flight sessions on five crewmembers (n=13) using the protocol described in Koppelmans et al. [2]. Balance control was assessed using CDP, with eyes closed and a sway-referenced base of support (Sensory Organization Test 5), with and without head movements in the pitch plane. Spatial working memory was assessed using Thurston's Card Rotation Test and a Mental Rotation Test. The Rod and Frame Test was performed to test visual dependence. The Digit Symbol Substitution Test was performed to evaluate processing speed, and the Purdue Pegboard Task was performed to test bimanual coordination. Vestibular function was assessed by eliciting ocular VEMP via a hand held striker on the side of the head as subjects lay supine on a gurney. Subjects also performed the Functional Mobility Test of walking through an obstacle course to assess rate of early motor learning. Data were also collected on the same crewmembers during three in-flight sessions on the International Space Station (ISS). In-flight, spatial working memory was assessed using the Mental Rotation Test, adaptation to visuo-motor transformation in manual control was assessed using the Sensorimotor Adaptation Test, and multi-tasking ability was assessed using the Dual Task Test. These three tests were performed in a strapped-in configuration mimicking a seated position - waist bungees pulled the crewmember toward the "floor" with feet secured in foot loops. The Mental Rotation Test was also performed in a free-floating configuration while the crewmember floated while holding on to the gamepad controller used to provide input that was secured to the equipment rack on the ISS. Preliminary findings from data collected to date, will be included in the presentation. Eventual comparison to results from supporting bed rest and longitudinal studies will enable the parsing out of the multiple mechanisms contributing to any observed spaceflight-induced sensorimotor and cognitive behavioral changes.
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- 2017
8. Behavioral, Brain Imaging and Genomic Measures to Predict Functional Outcomes Post-Bed Rest and Space Flight
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Mulavara, A. P, Peters, B, De Dios, Y. E, Gadd, N. E, Caldwell, E. E, Batson, C. D, Goel, R, Oddsson, L, Kreutzberg, G, Zanello, S, Clark, T. K, Oman, C. M, Cohen, H. S, Wood, S, Seidler, R. D, Reschke, M. F, and Bloomberg, J. J
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Aerospace Medicine ,Behavioral Sciences - Abstract
Astronauts experience sensorimotor disturbances during their initial exposure to microgravity and during the re-adaptation phase following a return to an Earth-gravitational environment. These alterations may disrupt crewmembers' ability to perform mission critical functional tasks requiring ambulation, manual control and gaze stability. Interestingly, astronauts who return from spaceflight show substantial differences in their abilities to readapt to a gravitational environment. The ability to predict the manner and degree to which individual astronauts are affected will improve the effectiveness of countermeasure training programs designed to enhance sensorimotor adaptability. For such an approach to succeed, we must develop predictive measures of sensorimotor adaptability that will allow us to foresee, before actual spaceflight, which crewmembers are likely to experience greater challenges to their adaptive capacities. The goals of this project are to identify and characterize this set of predictive measures. Our approach includes: 1) behavioral tests to assess sensory bias and adaptability quantified using both strategic and plastic-adaptive responses; 2) imaging to determine individual brain morphological and functional features, using structural magnetic resonance imaging (MRI), diffusion tensor imaging, resting state functional connectivity MRI, and sensorimotor adaptation task-related functional brain activation; and 3) assessment of genetic polymorphisms in the catechol-O-methyl transferase, dopamine receptor D2, and brain-derived neurotrophic factor genes and genetic polymorphisms of alpha2-adrenergic receptors that play a role in the neural pathways underlying sensorimotor adaptation. We anticipate that these predictive measures will be significantly correlated with individual differences in sensorimotor adaptability after long-duration spaceflight and exposure to an analog bed rest environment. We will be conducting a retrospective study, leveraging data already collected from relevant ongoing or completed bed rest and spaceflight studies. This data will be combined with predictor metrics that will be collected prospectively (as described for behavioral, brain imaging and genomic measures) from these returning subjects to build models for predicting post spaceflight and bed rest adaptive capability. In this presentation we will discuss the optimized set of tests for predictive metrics to be used for evaluating post mission adaptive capability as manifested in their outcome measures. Comparisons of model performance will allow us to better design and implement sensorimotor adaptability training countermeasures against decrements in post-mission adaptive capability that are customized for each crewmember's sensory biases, adaptive ability, brain structure, brain function, and genetic predispositions. The ability to customize adaptability training will allow more efficient use of crew time during training and will optimize training prescriptions for astronauts to mitigate the deleterious effects of spaceflight.
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- 2017
9. Evaluation of Galvanic Vestibular Stimulation System
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Kofman, I. S, Warren, E, DeSoto, R, Moroney, G, Chastain, J, De Dios, Y. E, Gadd, N, Taylor, L, Peters, B. T, Allen, E, Reschke, M. F, Bloomberg, J. J, and Mulavara, A. P
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Aerospace Medicine - Published
- 2017
10. Effects of One Year of Spaceflight on Neurocognitive Function
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Seidler, R. D, Mulavara, A. P, Koppelmans, V, Kofman, I. S, Cassady, K, Yuan , P, De Dios, Y. E, Gadd, N, Riascos, R. F, Wood, S. J, and Bloomberg, J. J
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Aerospace Medicine - Abstract
It is known that spaceflight adversely affects human sensorimotor function. With interests in longer duration deep space missions it is important to understand microgravity dose-response relationships. NASA's One Year Mission project allows for comparison of the effects of one year in space with those seen in more typical six month missions to the International Space Station. In the Neuromapping project we are performing structural and functional magnetic resonance brain imaging to identify the relationships between changes in neurocognitive function and neural structural alterations following a six month International Space Station mission. Our central hypothesis is that measures of brain structure, function, and network integrity will change from pre- to post-spaceflight. Moreover, we predict that these changes will correlate with indices of cognitive, sensory, and motor function in a neuroanatomically selective fashion. Our interdisciplinary approach utilizes cutting edge neuroimaging techniques and a broad-ranging battery of sensory, motor, and cognitive assessments that are conducted pre-flight, during flight, and post-flight to investigate potential neuroplastic and maladaptive brain changes in crewmembers following long-duration spaceflight. With the one year mission we had one crewmember participate in all of the same measures pre-, per- and post-flight as in our ongoing study. During this presentation we will provide an overview of the magnitude of changes observed with our brain and behavioral assessments for the one year crewmember in comparison to participants that have completed our six month study to date.
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- 2017
11. Long Duration Head Down Tilt Bed Rest and Spaceflight Effects on Neurocognitive Performance: Extent, Longevity and Neural Bases
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Seidler, R. D, Mulavara, A. P, Koppelmans, V, Cassady, K, Yuan, P, Kofman, I. S, De Dios, Y. E, Riascos-Castaneda, R. F, Wood, S. J, and Bloomberg, J. J
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Aerospace Medicine ,Behavioral Sciences - Abstract
We have recently completed a long duration head down tilt bed rest (HDBR) study in which we performed structural and functional magnetic resonance brain imaging to identify the relationships between changes in neurocognitive function and neural structural alterations in a spaceflight analog environment. We are also collecting the same measures in crewmembers prior to and following a six month International Space Station mission. We will present data demonstrating that bed rest resulted in functional mobility and balance deterioration with recovery post-HDBR. We observed numerous changes in brain structure, function, and connectivity relative to a control group which were associated with pre to post bed rest changes in sensorimotor function. For example, gray matter volume (GMv) increased in posterior parietal areas and decreased in frontal regions. GMv increases largely overlapped with fluid decreases and vice versa. Larger increases in precentral gyrus (M1)/ postcentral gyrus (S1+2) GMv and fluid decreases were associated with smaller balance decrements. Vestibular activation in the bilateral insular cortex increased with bed rest and subsequently recovered. Larger increases in vestibular activation in multiple brain regions were associated with greater decrements in balance and mobility. We found connectivity increases between left M1 with right S1+2 and the superior parietal lobule, and right vestibular cortex with the cerebellum. Decreases were observed between right Lobule VIII with right S1+2 and the supramarginal gyrus, right posterior parietal cortex (PPC) with occipital regions, and the right superior posterior fissure with right Crus I and II. Connectivity strength between left M1 and right S1+2/superior parietal lobule increased the most in individuals that exhibited the least balance impairments. In sum, we observed HDBR-related changes in measures of brain structure, function, and network connectivity, which correlated with indices of sensorimotor function. Recovery was observed post HDBR but remained incomplete at 12 days post-HDBR. Preliminary findings from our parallel ongoing flight study will be compared and contrasted with bed rest results during this presentation.
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- 2017
12. Spaceflight Effects on Neurocognitive Performance: Extent, Longevity and Neural Bases
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Seidler, R. D, Mulavara, A. P, Koppelmans, V, Kofman, I. S, Cassady, K, Yuan, P, De Dios, Y. E, Gadd, N, Riascos, R. F, Wood, S. J, and Bloomberg, J. J
- Subjects
Aerospace Medicine ,Behavioral Sciences - Abstract
We are conducting ongoing experiments in which we are performing structural and functional magnetic resonance brain imaging to identify the relationships between changes in neurocognitive function and neural structural alterations following a six month International Space Station mission. Our central hypothesis is that measures of brain structure, function, and network integrity will change from pre to post spaceflight. Moreover, we predict that these changes will correlate with indices of cognitive, sensory, and motor function in a neuroanatomically selective fashion. Our interdisciplinary approach utilizes cutting edge neuroimaging techniques and a broad ranging battery of sensory, motor, and cognitive assessments that are conducted pre flight, during flight, and post flight to investigate potential neuroplastic and maladaptive brain changes in crewmembers following long-duration spaceflight. Success in this endeavor would 1) result in identification of the underlying neural mechanisms and operational risks of spaceflight-induced changes in behavior, and 2) identify whether a return to normative behavioral function following re-adaptation to Earth's gravitational environment is associated with a restitution of brain structure and function or instead is supported by substitution with compensatory brain processes. We have collected data on several crewmembers and preliminary findings will be presented. Eventual comparison to results from our parallel bed rest study will enable us to parse out the multiple mechanisms contributing to any spaceflight-induced neural structural and behavioral changes that we observe.
- Published
- 2017
13. Estimation of Optimum Stimulus Amplitude for Balance Training using Electrical Stimulation of the Vestibular System
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Goel, R, Rosenberg, M. J, De Dios, Y. E, Cohen, H. S, Bloomberg, J. J, and Mulavara, A. P
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Aerospace Medicine - Abstract
Sensorimotor changes such as posture and gait instabilities can affect the functional performance of astronauts after gravitational transitions. Sensorimotor Adaptability (SA) training can help alleviate decrements on exposure to novel sensorimotor environments based on the concept of 'learning to learn' by exposure to varying sensory challenges during posture and locomotion tasks (Bloomberg 2015). Supra-threshold Stochastic Vestibular Stimulation (SVS) can be used to provide one of many challenges by disrupting vestibular inputs. In this scenario, the central nervous system can be trained to utilize veridical information from other sensory inputs, such as vision and somatosensory inputs, for posture and locomotion control. The minimum amplitude of SVS to simulate the effect of deterioration in vestibular inputs for preflight training or for evaluating vestibular contribution in functional tests in general, however, has not yet been identified. Few studies (MacDougall 2006; Dilda 2014) have used arbitrary but fixed maximum current amplitudes from 3 to 5 mA in the medio-lateral (ML) direction to disrupt balance function in healthy adults. Giving this high level of current amplitude to all the individuals has a risk of invoking side effects such as nausea and discomfort. The goal of this study was to determine the minimum SVS level that yields an equivalently degraded balance performance. Thirteen subjects stood on a compliant foam surface with their eyes closed and were instructed to maintain a stable upright stance. Measures of stability of the head, trunk, and whole body were quantified in the ML direction. Duration of time they could stand on the foam surface was also measured. The minimum SVS dosage was defined to be that level which significantly degraded balance performance such that any further increase in stimulation level did not lead to further balance degradation. The minimum SVS level was determined by performing linear fits on the performance variable at different stimulation levels. Results from the balance task suggest that there are inter-individual differences and the minimum SVS amplitude was found to be in the range of 1 mA to 2.5 mA across subjects. SVS resulted in an average decrement of balance task performance in the range of 62%-73% across different measured variables at the minimum SVS amplitude in comparison to the control trial (no stimulus). Training using supra-threshold SVS stimulation is one of the sensory challenges used for preflight SA training designed to improve adaptability to novel gravitational environments. Inter-individual differences in response to SVS can help customize the SA training paradigms using minimal dosage required. Another application of using SVS is to simulate acute deterioration of vestibular sensory inputs in the evaluation of tests for assessing vestibular function.
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- 2016
14. Exercise Effects on the Brain and Sensorimotor Function in Bed Rest
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Koppelmans, V, Cassady, K, De Dios, Y. E, Szecsy, D, Gadd, N, Wood, S. J, Reuter-Lorenz, R. A, Kofman, I, Bloomberg, J. J, Mulavara, A. P, Ploutz-Snyder, L, and Seidler, R. D
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Aerospace Medicine - Abstract
Long duration spaceflight microgravity results in cephalad fluid shifts and deficits in posture control and locomotion. Effects of microgravity on sensorimotor function have been investigated on Earth using head down tilt bed rest (HDBR). HDBR serves as a spaceflight analogue because it mimics microgravity in body unloading and bodily fluid shifts. Preliminary results from our prior 70 days HDBR studies showed that HDBR is associated with focal gray matter (GM) changes and gait and balance deficits, as well as changes in brain functional connectivity. In consideration of the health and performance of crewmembers we investigated whether exercise reduces the effects of HDBR on GM, functional connectivity, and motor performance. Numerous studies have shown beneficial effects of exercise on brain health. We therefore hypothesized that an exercise intervention during HDBR could potentially mitigate the effects of HDBR on the central nervous system. Eighteen subjects were assessed before (12 and 7 days), during (7, 30, and ~70 days) and after (8 and 12 days) 70 days of 6-degrees HDBR at the NASA HDBR facility in UTMB, Galveston, TX, US. Each subject was randomly assigned to a control group or one of two exercise groups. Exercise consisted of daily supine exercise which started 20 days before the start of HDBR. The exercise subjects participated either in regular aerobic and resistance exercise (e.g. squat, heel raise, leg press, cycling and treadmill running), or aerobic and resistance exercise using a flywheel apparatus (rowing). Aerobic and resistance exercise intensity in both groups was similar, which is why we collapsed the two exercise groups for the current experiment. During each time point T1-weighted MRI scans and resting state functional connectivity scans were obtained using a 3T Siemens scanner. Focal changes over time in GM density were assessed using voxel based morphometry (VBM8) under SPM. Changes in resting state functional connectivity was assessed using both a region of interest (ROI, or seed-to-voxel) approach as well as a whole brain intrinsic connectivity (i.e., voxel-to-voxel) analysis. For the ROI analysis we selected 11 ROIs of brain regions that are involved in sensorimotor function (i.e., L. Insular C., L. Putamen, R. Premotor C., L.+R. Primary Motor C., R. Vestibular C., L. Posterior Cingulate G., R. Cerebellum Lobule V + VIIIb + Crus I, and the R. Superior Parietal G.) and correlated their time course of brain activation during rest with all other voxels in the brain. The whole brain connectivity analysis tests changes in the strength of the global connectivity pattern between each voxel and the rest of the brain. Functional mobility was assessed using an obstacle course. Vestibular contribution to balance was measured using Neurocom Sensory Organization Test 5. Behavioral measures were assessed pre-HDBR, and 0, 8 and 12 days post-HDBR. Linear mixed models were used to test for effects of time, group, and group-by-time interactions. Family-wise error corrected VBM revealed significantly larger increases in GM volume in the right primary motor cortex in bed rest control subjects than in bed rest exercise subjects. No other significant group by time interactions in gray matter changes with bed rest were observed. Functional connectivity MRI revealed that the increase in connectivity during bed rest of the left putamen with the bilateral midsagittal precunes and the right cingulate gyrus was larger in bed rest control subjects than in bed rest exercise subjects. Furthermore, the increase in functional connectivity with bed rest of the right premotor cortex with the right inferior frontal gyrus and the right primary motor cortex with the bilateral premotor cortex was smaller in bed rest control subjects than in bed rest exercise subjects. Functional mobility performance was less affected by HDBR in exercise subjects than in control subjects and post HDBR exercise subjects recovered faster than control subjects. The group performance differences and GM changes were not related. Exercise in HDBR partially mitigates the adverse effect of HDBR on functional mobility, particularly during the post-bed rest recovery phase. In addition, exercise appears to result in differential brain structural and functional changes in motor regions such as the primary motor cortex, the premotor cortex and the putamen. Whether these central nervous system changes are related to motor behavioral changes including gait and balance warrants further research.
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- 2016
15. Predictive Measures of Locomotor Performance on an Unstable Walking Surface
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Bloomberg, J. J, Peters, B. T, Mulavara, A. P, Caldwell, E. E, Batson, C. D, De Dios, Y. E, Gadd, N. E, Goel, R, Wood, S. J, Cohen, H. S, Oddsson, L. I, and Seidler, R. D
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Aerospace Medicine - Abstract
Locomotion requires integration of visual, vestibular, and somatosensory information to produce the appropriate motor output to control movement. The degree to which these sensory inputs are weighted and reorganized in discordant sensory environments varies by individual and may be predictive of the ability to adapt to novel environments. The goals of this project are to: 1) develop a set of predictive measures capable of identifying individual differences in sensorimotor adaptability, and 2) use this information to inform the design of training countermeasures designed to enhance the ability of astronauts to adapt to gravitational transitions improving balance and locomotor performance after a Mars landing and enhancing egress capability after a landing on Earth.
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- 2016
16. Efficacy of Stochastic Vestibular Stimulation to Improve Locomotor Performance in a Discordant Sensory Environment
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Temple, D. R, De Dios, Y. E, Layne, C. S, Bloomberg, J. J, and Mulavara, A. P
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Man/System Technology And Life Support ,Aerospace Medicine - Abstract
Astronauts exposed to microgravity face sensorimotor challenges incurred when readapting to a gravitational environment. Sensorimotor Adaptability (SA) training has been proposed as a countermeasure to improve locomotor performance during re-adaptation, and it is suggested that the benefits of SA training may be further enhanced by improving detection of weak sensory signals via mechanisms such as stochastic resonance when a non-zero level of stochastic white noise based electrical stimulation is applied to the vestibular system (stochastic vestibular stimulation, SVS). The purpose of this study was to test the efficacy of using SVS to improve short-term adaptation in a sensory discordant environment during performance of a locomotor task.
- Published
- 2016
17. Development of a Protocol to Test Proprioceptive Utilization as a Predictor for Sensorimotor Adaptability
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Goel, R, De Dios, Y. E, Gadd, N. E, Caldwell, E. E, Peters, B. T, Bloomberg, J. J, Oddsson, L. I. E, and Mulavara, A. P
- Subjects
Aerospace Medicine - Abstract
Astronauts returning from space flight show significant inter-subject variations in their abilities to readapt to a gravitational environment because of their innate sensory weighting. The ability to predict the manner and degree to which each individual astronaut will be affected would improve the effectiveness of countermeasure training programs designed to enhance sensorimotor adaptability. We hypothesize participant's ability to utilize individual sensory information (vision, proprioception and vestibular) influences adaptation in sensorimotor performance after space flight. The goal of this study is to develop a reliable protocol to test proprioceptive utilization in a functional postural control task. Subjects "stand" in a supine position while strapped to a backpack frame holding a friction-free device using air-bearings that allow the subject to move freely in the frontal plane, similar to when in upright standing. The frame is attached to a pneumatic cylinder, which can provide different levels of a gravity-like force that the subject must balance against to remain "upright". The supine posture with eyes closed ensures reduced vestibular and visual contribution to postural control suggesting somatosensory and/or non-otolith vestibular inputs will provide relevant information for maintaining balance control in this task. This setup is called the gravity bed. Fourteen healthy subjects carried out three trials each with eyes open alternated with eyes closed, "standing" on their dominant leg in the gravity bed environment while loaded with 60 percent of their body weight. Subjects were instructed to: "use your sense of sway about the ankle and pressure changes under the foot to maintain balance." Maximum length of a trial was 45 seconds. A force plate underneath the foot recorded forces and moments during the trial and an inertial measurement unit (IMU) attached on the backpack's frame near the center of mass of the subject recorded upper body postural responses. Series of linear and non-linear analyses were carried out on several force plate and IMU data including stabilogram diffusion analysis on the center of pressure (COP) to find a subset of parameters that were sensitive to detect differences in postural performance between eyes open and closed conditions. Results revealed that seven parameters (root mean square (RMS) of medio-lateral (ML) COP, range of ML COP, RMS of roll moment, range of trunk roll, minimum time-to-boundary (TTB), integrated TTB, and critical mean square planar displacement (delta r (sup 2) (sub c)) were significantly different between eyes open and closed conditions. We will present data to show the efficacy of using performance in single leg stance with eyes closed on the gravity bed to assess individuals' ability to utilize proprioceptive information in a functional postural control task to predict re-adaptation for sensorimotor and functional performance.
- Published
- 2016
18. Ocular Vestibular Evoked Myogenic Potentials Using Head Striker Stimulation
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De Dios, Y. E, Gadd, N. E, Kofman, I. S, Peters, B. T, Reschke, M, Bloomberg, J. J, Wood, S. J, Noohibezanjani, F, Kinnaird, C, Seidler, R. D, and Mulavara, A. P
- Subjects
Aerospace Medicine - Abstract
Introduction: Over the last two decades, several studies have been published on the impact of long-duration (i.e., 22 days or longer) spaceflight on the central nervous system (CNS). In consideration of the health and performance of crewmembers in flight and post-flight, we are conducting a controlled prospective longitudinal study to investigate the effects of spaceflight on the extent, longevity and neural bases of sensorimotor, cognitive, and neural changes. Multiple studies have demonstrated the effects of spaceflight on the vestibular system. One of the supporting tests conducted in this protocol is the Vestibular Evoked Myogenic Potential (VEMP) test that provides a unilateral measure of otolith (saccule and utricle) function. A different approach was taken for ocular VEMP (oVEMP) testing using a head striker system (Wackym et al. 2012). The oVEMP is generally considered to be a measure of utricle function. The the otolithic input to the inferior oblique muscle is predominately from the utricular macula. Thus, quantitatively, oVEMP tests utricular function. Another practical extension of these relationships is that the oVEMP reflects the superior vestibular nerve function. Methods: Ground testing was administered on 16 control subjects and for 8 subjects over four repeated sessions spanning 70 days. The oVEMP was elicitied via a hand held striker by a vibrotactile pulse presented at the rate of 1 Hz for 24 seconds on the side of the head as subjects lay supine on a gurney. Subjects were directed to gaze approximately 25 degrees above straight ahead in semi-darkness. For the oVEMP electromyograms will be recorded with active bipolar electrodes (Delsys Inc., Boston, MA) on the infra-orbital ridge 1 cm below the eyelid with a reference electrode on the below the knee cap. The EMG potentials were amplified; band-pass filtered using a BagnoliTM Desktop EMG System (Delsys Inc., Boston, MA, USA). This EMG signal is sampled at 10 kHz and the data stimulus onset to 100 MS was averaged over 24 trial repetitions for the vibrotactile VEMP. The typical oVEMP EMG response is an excitatory potential with first peak occurring at 11-12 ms and second peak at 18 ms. This requires a total recording time of approximately 29 seconds per trial which includes 5 seconds of no vibrotactile stimulation at the beginning of the protocol. The primary dependent measures consist of the latency and peak-to-peak amplitude from the EMG signals, which will be normalized to EMG levels at the beginning of the protocol. Data were collected for 3 repeated trials with striker stimulation on both the left and right side of the head Results: The oVEMP p1 range was observed at 3-14 ms and n1 at 7-19 ms. The striker system provided a consistent and rapid method for oVEMP testing. Discussion: Crew testing is in progress to determine changes in results between pre and post flight.
- Published
- 2016
19. Relationships Between Vestibular Measures as Potential Predictors for Spaceflight Sensorimotor Adaptation
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Clark, T. K, Peters, B, Gadd, N. E, De Dios, Y. E, Wood, S, Bloomberg, J. J, and Mulavara, A. P
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Aerospace Medicine - Abstract
Introduction: During space exploration missions astronauts are exposed to a series of novel sensorimotor environments, requiring sensorimotor adaptation. Until adaptation is complete, sensorimotor decrements occur, affecting critical tasks such as piloted landing or docking. Of particularly interest are locomotion tasks such as emergency vehicle egress or extra-vehicular activity. While nearly all astronauts eventually adapt sufficiently, it appears there are substantial individual differences in how quickly and effectively this adaptation occurs. These individual differences in capacity for sensorimotor adaptation are poorly understood. Broadly, we aim to identify measures that may serve as pre-flight predictors of and individual's adaptation capacity to spaceflight-induced sensorimotor changes. As a first step, since spaceflight is thought to involve a reinterpretation of graviceptor cues (e.g. otolith cues from the vestibular system) we investigate the relationships between various measures of vestibular function in humans. Methods: In a set of 15 ground-based control subjects, we quantified individual differences in vestibular function using three measures: 1) ocular vestibular evoked myogenic potential (oVEMP), 2) computerized dynamic posturography and 3) vestibular perceptual thresholds. oVEMP responses are elicited using a mechanical stimuli approach. Computerized dynamic posturography was used to quantify Sensory Organization Tests (SOTs), including SOT5M which involved performing pitching head movements while balancing on a sway-reference support surface with eyes closed. We implemented a vestibular perceptual threshold task using the tilt capabilities of the Tilt-Translation Sled (TTS) at JSC. On each trial, the subject was passively roll-tilted left ear down or right ear down in the dark and verbally provided a forced-choice response regarding which direction they felt tilted. The motion profile was a single-cycle sinusoid of angular acceleration with a duration of 5 seconds (frequency of 0.2 Hz), which was selected as it requires sensory integration of otolith and semicircular canal cues. Stimuli direction was randomized and magnitude was determined using an adaptive sampling procedure. One hundred trials were provided and each subject's responses were fit with a psychometric curve to estimate the subject's threshold. Results: Roll tilt perceptual thresholds at 0.2 Hz ranged from 0.5 degrees to 1.82 degrees across the 15 subjects (geometric mean of 1.04 degrees), consistent with previous studies. The inter-individual variability in thresholds may be able to help explain individual differences observed in sensorimotor adaptation to spaceflight. Analysis is ongoing for the oVEMPS and computerized dynamic posturography to identify relationships between the various vestibular measures. Discussion: Predicting individual differences in sensorimotor adaptation is critical both for the development of personalized countermeasures and mission planning. Here we aim to develop a basis of vestibular tests and parameters which may serve as predictors of individual differences in sensorimotor adaptability through studying the relationship between these measures.
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- 2016
20. The Effects of Long Duration Bed Rest on Brain Functional Connectivity and Sensorimotor Functioning
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Cassady, K, Koppelmans, V, De Dios, Y, Stepanyan, V, Szecsy, D, Gadd, N, Wood, S, Reuter-Lorenz, P, Castenada, R. Riascos, Kofman, I, Bloomberg, J, Mulavara, A, and Seidler, R
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Aerospace Medicine ,Behavioral Sciences - Abstract
Long duration spaceflight has been associated with detrimental alterations in human sensorimotor functioning. Prolonged exposure to a head-down tilt (HDT) position during long duration bed rest can resemble several effects of the microgravity environment such as reduced sensory inputs, body unloading and increased cephalic fluid distribution. The question of whether microgravity affects other central nervous system functions such as brain functional connectivity and its relationship with behavior is largely unknown, but of importance to the health and performance of astronauts both during and post-flight. In the present study, we investigate the effects of prolonged exposure to HDT bed rest on resting state brain functional connectivity and its association with behavioral changes in 17 male participants. To validate that our findings were not due to confounding factors such as time or task practice, we also acquired resting state functional magnetic resonance imaging (rs-fMRI) and behavioral measurements from 14 normative control participants at four time points. Bed rest participants remained in bed with their heads tilted down six degrees below their feet for 70 consecutive days. Rs-fMRI and behavioral data were obtained at seven time points averaging around: 12 and 8 days prior to bed rest; 7, 50, and 70 days during bed rest; and 8 and 12 days after bed rest. 70 days of HDT bed rest resulted in significant increases in functional connectivity during bed rest followed by a reversal of changes in the post bed rest recovery period between motor cortical and somatosensory areas of the brain. In contrast, decreases in connectivity were observed between temporoparietal regions. Furthermore, post-hoc correlation analyses revealed a significant relationship between motor-somatosensory network connectivity and standing balance performance changes; participants that exhibited the greatest increases in connectivity strength showed the least deterioration in postural equilibrium with HDT bed rest. This suggests that neuroplastic processes may facilitate adaptation to the HDT bed rest environment. The findings from this study provide novel insights into the neurobiology and future risk assessments of long-duration spaceflight.
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- 2016
21. Neuromapping: Inflight Evaluation of Cognition and Adaptability
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Kofman, I. S, De Dios, Y. E, Lawrence, K, Schade, A, Reschke, M. F, Bloomberg, J. J, Wood, S. J, Mulavara, A. P, and Seidle, R. D
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Behavioral Sciences ,Aerospace Medicine - Abstract
In consideration of the health and performance of crewmembers during flight and postflight, we are conducting a controlled prospective longitudinal study to investigate the effects of spaceflight on the extent, longevity and neural bases of sensorimotor, cognitive, and neural changes. Previous studies investigating sensorimotor adaptation to the microgravity environment longitudinally inflight have shown reduction in the ability to perform complex dual tasks. In this study we perform a series of tests investigating the longitudinal effects of adaptation to the microgravity environment and how it affects spatial cognition, manual visuo-motor adaption and dual tasking.
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- 2016
22. Brain and Behavioral Evidence for Reweighting of Vestibular Inputs with Long-Duration Spaceflight
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Hupfeld, K E, primary, McGregor, H R, additional, Koppelmans, V, additional, Beltran, N E, additional, Kofman, I S, additional, De Dios, Y E, additional, Riascos, R F, additional, Reuter-Lorenz, P A, additional, Wood, S J, additional, Bloomberg, J J, additional, Mulavara, A P, additional, and Seidler, R D, additional
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- 2021
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23. Increased Brain Activation for Foot Movement During 70-Day 6 Deg Head-Down Bed Rest (HDBR): Evidence from Functional Magnetic Resonance Imaging (fMRI)
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Yuan, P, Koppelmans, V, Cassady, K, Cooke, K, De Dios, Y. E, Stepanyan, V, Szecsy, D, Gadd, N, Wood, S. J, Reuter‐Lorenz, P. A, Riascos‐Castaneda, R, Kofman, I, Bloomberg, J. J, Mulavara, A. P, and Seidler, R. D
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Aerospace Medicine - Abstract
Bed rest has been widely used as a simulation of weightlessness in studying the effects of microgravity exposure on human physiology and cognition. Changes in muscle function and functional mobility have been reported to be associated with bed rest. Understanding the effect of bed rest on neural control of movement would provide helpful information for spaceflight. In the current study, we evaluated how the brain activation for foot movement changed as a function of bed rest. Eighteen healthy men (aged 25 to 39 years) participated in this HDBR study. They remained continuously in the 6deg head‐down tilt position for 70 days. Functional MRI was acquired during 1‐Hz right foot tapping, and repeated at 7 time points: 12 days pre‐, 8 days pre‐, 7 days in‐, 50 days in‐, 70 days in‐, 8 days post‐, and 12 days post‐ HDBR. In all 7 sessions, we observed increased activation in the left motor cortex, right cerebellum and right occipital cortex during foot movement blocks compared to rest. Compared to the pre‐HDBR baseline (1st and 2nd sessions), foot movement‐induced activation in the left hippocampus increased during HDBR. This increase emerged in the 4th session, enlarged in the 5th session, and remained significant in the 6th and 7th sessions. Furthermore, increased activation relative to the baseline in left precuneus was observed in the 5th, 6th and 7th sessions. In addition, in comparison with baseline, increased activation in the left cerebellum was found in the 4th and 5th sessions, whereas increased activation in the right cerebellum was observed in the 4th, 6th and 7th sessions. No brain region exhibited decreased activation during bed rest compared to baseline. The increase of foot movement related brain activation during HDBR suggests that in a long‐term head‐down position, more neural control is needed to accomplish foot movements. This change required a couple of weeks to develop in HDBR (between 3rd and 4th sessions), and did not return to baseline even 12 days after HDBR. The observed effect of bed rest on brain activation during a foot tapping task could be linked to HDBR related changes in brain structure that we have recently reported. The relationship between pre‐ and post‐ HDBR changes in brain activation and performance in a functional mobility test will also be presented.
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- 2015
24. The Effects of Long Duration Bed Rest as a Spaceflight Analogue on Resting State Sensorimotor Network Functional Connectivity and Neurocognitive Performance
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Cassady, K, Koppelmans, V, Yuan, P, Cooke, K, De Dios, Y, Stepanyan, V, Szecsy, D, Gadd, N, Wood, S, Reuter-Lorenz, P, Castenada, R. Riascos, Kofman, I, Bloomberg, J, Mulavara, A, and Seidler, R
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Aerospace Medicine ,Behavioral Sciences - Abstract
Long duration spaceflight has been associated with detrimental alterations in human sensorimotor systems and neurocognitive performance. Prolonged exposure to a head-down tilt position during long duration bed rest can resemble several effects of the microgravity environment such as reduced sensory inputs, body unloading and increased cephalic fluid distribution. The question of whether microgravity affects other central nervous system functions such as brain functional connectivity and its relationship with neurocognitive performance is largely unknown, but of potential importance to the health and performance of astronauts both during and post-flight. The aims of the present study are 1) to identify changes in sensorimotor resting state functional connectivity that occur with extended bed rest exposure, and to characterize their recovery time course; 2) to evaluate how these neural changes correlate with neurocognitive performance. Resting-state functional magnetic resonance imaging (rsfMRI) data were collected from 17 male participants. The data were acquired through the NASA bed rest facility, located at the University of Texas Medical Branch (Galveston, TX). Participants remained in bed with their heads tilted down six degrees below their feet for 70 consecutive days. RsfMRI data were obtained at seven time points: 7 and 12 days before bed rest; 7, 50, and 65 days during bed rest; and 7 and 12 days after bed rest. Functional connectivity magnetic resonance imaging (fcMRI) analysis was performed to measure the connectivity of sensorimotor networks in the brain before, during, and post-bed rest. We found a decrease in left putamen connectivity with the pre- and post-central gyri from pre bed rest to the last day in bed rest. In addition, vestibular cortex connectivity with the posterior cingulate cortex decreased from pre to post bed rest. Furthermore, connectivity between cerebellar right superior posterior fissure and other cerebellar regions decreased from pre bed rest to the last day in bed rest. In contrast, connectivity within the default mode network remained stable over the course of bed rest. We also utilized a battery of behavioral measures including spatial working memory tasks and measures of functional mobility and balance. These behavioral measurements were collected before, during, and after bed rest. We will report the preliminary findings of correlations observed between brain functional connectivity and behavioral performance changes. Our results suggest that sensorimotor brain networks exhibit decoupling with extended periods of reduced usage. The findings from this study could aid in the understanding and future design of targeted countermeasures to alleviate the detrimental health and neurocognitive effects of long-duration spaceflight.
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- 2015
25. Focal Gray Matter Plasticity as a Function of Long Duration Bedrest: Preliminary Results
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Koppelmans, V, Erdeniz, B, De Dios, Y. E, Wood, S. J, Reuter-Lorenz, P. A, Kofman, I, Bloomberg, J. J, Mulavara, A. P, and Seidler, R. D
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Aerospace Medicine - Abstract
Long duration spaceflight (i.e., 22 days or longer) has been associated with changes in sensorimotor systems, resulting in difficulties that astronauts experience with posture control, locomotion, and manual control. It is unknown whether and how spaceflight impacts sensorimotor brain structure and function, and whether such changes may potentially underlie behavioral effects. Long duration head down tilt bed rest has been used repeatedly as an exclusionary analog to study microgravity effects on the sensorimotor system [1]. Bed rest mimics microgravity in body unloading and bodily fluid shifts. We are currently testing sensorimotor function, brain structure, and brain function pre and post a 70‐day bed rest period. We will acquire the same measures on NASA crewmembers starting in 2014. Here we present the results of the first eight bed rest subjects. Subjects were assessed at 12 and 7 days before‐, at 7, 30, and ~70 days in‐, and at 8 and 12 days post 70 days of bed rest at the NASA bed rest facility, UTMB, Galveston, TX, USA. At each time point structural MRI scans (i.e., high resolution T1‐weighted imaging and Diffusion Tensor Imaging (DTI)) were obtained using a 3T Siemens scanner. Focal changes over time in gray matter density were assessed using the voxel based morphometry 8 (VBM8) toolbox under SPM. Focal changes in white matter microstructural integrity were assessed using tract based spatial statistics (TBSS) as part of the FMRIB software library (FSL). TBSS registers all DTI scans to standard space. It subsequently creates a study specific white matter skeleton of the major white matter tracts. Non‐parametric permutation based t‐tests and ANOVA's were used for voxel‐wise comparison of the skeletons. For both VBM and TBSS, comparison of the two pre bed rest measurements did not show significant differences. VBM analysis revealed decreased gray matter density in bilateral areas including the frontal medial cortex, the insular cortex and the caudate nucleus from pre to in bed rest. Over the same time period, there was an increase in gray matter density in the cerebellum, occipital, and parietal cortices. The majority of these changes did not recover from during to post bed rest. TBSS analyses will also be presented. Extended bed rest, which is an analog for microgravity, can result in gray matter changes and potentially in microstructural white matter changes in areas that are important for neuromotor behavior and cognition. These changes did not recover at two weeks post bed rest. These results have significant public health implications, and will also aid in interpretation of our future data obtained pre and post spaceflight. Whether the effects of bed rest wear off at longer times post bed rest, and if they are associated with behavior are important questions that warrant further research.
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- 2014
26. Improving Sensorimotor Adaptation Following Long Duration Space Flight by Enhancing Vestibular Information Transfer
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Mulavara, A. P, Kofman, I. S, De Dios, Y. E, Galvan, R, Goel, R, Miller, C, Peters, B, Cohen, H. S, Jeevarajan, J, Reschke, M, Wood, S, Bergquist, F, Seidler, R. D, and Bloomberg, J. J
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Aerospace Medicine - Abstract
Crewmember adapted to the microgravity state may need to egress the vehicle within a few minutes for safety and operational reasons after gravitational transitions. The transition from one sensorimotor state to another consists of two main mechanisms: strategic and plastic-adaptive and have been demonstrated in astronauts returning after long duration space flight. Strategic modifications represent "early adaptation" - immediate and transitory changes in control that are employed to deal with short-term changes in the environment. If these modifications are prolonged then plastic-adaptive changes are evoked that modify central nervous system function, automating new behavioral responses. More importantly, this longer term adaptive recovery mechanism was significantly associated with their strategic ability to recover on the first day after return to Earth G. We are developing a method based on stochastic resonance to enhance information transfer by improving the brain's ability to detect vestibular signals (Vestibular Stochastic Resonance, VSR) especially when combined with balance training exercises such as sensorimotor adaptability (SA) training for rapid improvement in functional skill, for standing and mobility. This countermeasure to improve detection of vestibular signals is a stimulus delivery system that is wearable/portable providing low imperceptible levels of white noise based binaural bipolar electrical stimulation of the vestibular system (stochastic vestibular stimulation). To determine efficacy of vestibular stimulation on physiological and perceptual responses during otolith-canal conflicts and dynamic perturbations we have conducted a series of studies: We have shown that imperceptible binaural bipolar electrical stimulation of the vestibular system across the mastoids enhances balance performance in the mediolateral (ML) plane while standing on an unstable surface. We have followed up on the previous study showing VSR stimulation improved balance performance in both ML and anteroposterior planes while stimulating in the ML axis only. We have shown the efficacy of VSR stimulations on enhancing physiological and perceptual responses of whole-body orientation during low frequency perturbations (0.1 Hz) on the ocular motor system using a variable radius centrifuge on both physiological (using eye movements) and perceptual responses (using a joystick) to track imposed oscillations. The variable radius centrifuge provides a selective tilting sensation that is detectable only by the otolith organs providing conflicting information from the canal organs of the vestibular system (intra-vestibular conflict). These results indicate that VSR can improve performance in sensory conflict scenarios like that experienced during space flight. We have showed the efficacy of VSR stimulation to improve balance and locomotor control on subjects exposed to continuous, sinusoidal lateral motion of the support surface while walking on a treadmill while viewing perceptually matched linear optic flow. We have shown the safety of short term continuous use of up to 4 hours of VSR stimulation and its efficacy in improving balance and locomotor function in Parkinson's Disease patients. This technique for improving vestibular signal detection may thus provide additional information to improve strategic abilities. We hypothesize that VSR stimulation will act synergistically with SA training to improve adaptability by increased utilization of vestibular information and therefore serve to optimize and personalize the SA countermeasure prescription. This forms the basis of its usefulness both as a training modality and further help in significantly reducing the number of days required to recover functional performance to preflight levels after long duration space flight.
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- 2014
27. Assessment of Proficiency During Simulated Rover Operations Following Long-Duration Spaceflight
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Wood, S. J, Dean, S. L, De Dios, Y. E, MacDougall, H. G, and Moore, S. T
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Lunar And Planetary Science And Exploration - Abstract
Following long-duration space travel, pressurized rovers will enhance crew mobility to explore Mars and other planetary surfaces. Adaptive changes in sensorimotor function may limit the crew s proficiency when performing some rover operations shortly after transition to the new gravitoinertial environment. The primary goal of this investigation is to quantify postflight decrements in operational proficiency in a motion-based rover simulation after International Space Station (ISS) expeditions. Given that postflight performance will also be influenced by the level of preflight proficiency attained, a ground-based normative study was conducted to characterize the acquisition of skills over multiple sessions.
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- 2011
28. Assessment of Spatial Navigation and Docking Performance During Simulated Rover Tasks
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Wood, S. J, Dean, S. L, De Dios, Y. E, and Moore, S. T
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Space Transportation And Safety - Abstract
INTRODUCTION: Following long-duration exploration transits, pressurized rovers will enhance surface mobility to explore multiple sites across Mars and other planetary bodies. Multiple rovers with docking capabilities are envisioned to expand the range of exploration. However, adaptive changes in sensorimotor and cognitive function may impair the crew s ability to safely navigate and perform docking tasks shortly after transition to the new gravitoinertial environment. The primary goal of this investigation is to quantify post-flight decrements in spatial navigation and docking performance during a rover simulation. METHODS: Eight crewmembers returning from the International Space Station will be tested on a motion simulator during four pre-flight and three post-flight sessions over the first 8 days following landing. The rover simulation consists of a serial presentation of discrete tasks to be completed within a scheduled 10 min block. The tasks are based on navigating around a Martian outpost spread over a 970 sq m terrain. Each task is subdivided into three components to be performed as quickly and accurately as possible: (1) Perspective taking: Subjects use a joystick to indicate direction of target after presentation of a map detailing current orientation and location of the rover with the task to be performed. (2) Navigation: Subjects drive the rover to the desired location while avoiding obstacles. (3) Docking: Fine positioning of the rover is required to dock with another object or align a camera view. Overall operator proficiency will be based on how many tasks the crewmember can complete during the 10 min time block. EXPECTED RESULTS: Functionally relevant testing early post-flight will develop evidence regarding the limitations to early surface operations and what countermeasures are needed. This approach can be easily adapted to a wide variety of simulated vehicle designs to provide sensorimotor assessments for other operational and civilian populations.
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- 2010
29. Jean DANÉLOU. Los símbolos cristianos primitivos, Bilbao, Ediciones Ega, colec. Trípode, 1993, 122 págs.
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Eva Mª de Dios y Sánchez
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historia religiosa ,judaísmo ,cristianismo ,simbología ,Special aspects of education ,LC8-6691 ,History (General) and history of Europe - Abstract
Este estudio de teología del judeo cristianismo y de patrística grecolatina han dado como resultado publicaciones: La palma, La ímagen del árbol, El símbolo del agua, La nave, El carro de Elfas, El arado.
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- 1997
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30. Multi-day Adaptation and Savings in Manual and Locomotor Tasks
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Ruitenberg, M. F. L., primary, De Dios, Y. E., additional, Gadd, N. E., additional, Wood, S. J., additional, Reuter-Lorenz, P. A., additional, Kofman, I., additional, Bloomberg, J. J., additional, Mulavara, A. P., additional, and Seidler, R. D., additional
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- 2017
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31. Multi-day Adaptation and Savings in Manual and Locomotor Tasks.
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Ruitenberg, M. F. L., De Dios, Y. E., Gadd, N. E., Wood, S. J., Reuter-Lorenz, P. A., Kofman, I., Bloomberg, J. J., Mulavara, A. P., and Seidler, R. D.
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MUSCULOSKELETAL system , *GAIT disorders , *VISUAL fields , *SHORT-term memory , *HUMAN locomotion , *PHYSIOLOGICAL adaptation , *COMPARATIVE studies , *INDIVIDUALITY , *LEARNING , *RESEARCH methodology , *MEDICAL cooperation , *PSYCHOLOGY of movement , *RESEARCH , *EVALUATION research - Abstract
Using an individual differences approach, we evaluated whether manual and locomotor adaptation are associated in terms of adaptation and savings across days, and whether they rely on shared underlying mechanisms involving visuospatial working memory or visual field dependence. Participants performed a manual and a locomotor adaptation task during 4 separate test sessions over a 3-month period. Reliable adaptation and savings were observed for both tasks. It was further found that higher visuospatial working memory performance and lower visual field dependence scores were associated with faster learning in the manual and locomotor tasks, respectively. Moreover, adaptation rates were correlated between the 2 tasks in the final test session, suggesting that people may gradually be learning something generalizable about the adaptation process. [ABSTRACT FROM AUTHOR]
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- 2018
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32. Un programa de escuelas de famlias (III Plan regional de Drogas de Castilla y León)
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RAMÍREZ GUTIÉRREZ, Rafael, primary and DE DIOS DE DIOS, Y., additional
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- 1999
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33. Children of alcoholics in Spain: from risk to pathology. Results from the ALFIL program.
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Díaz R, Gual A, García M, Arnau J, Pascual F, Cañuelo B, Rubio G, de Dios Y, Fernández-Eire MC, Valdés R, Garbayo I, Díaz, Rosa, Gual, Antoni, García, Montse, Arnau, Jaume, Pascual, Francisco, Cañuelo, Bartolomé, Rubio, Gabriel, de Dios, Yolanda, and Fernández-Eire, M Carmen
- Abstract
Objective: To identify the possible risk factors and negative outcomes associated with parental alcoholism. A secondary aim was to determine the influence of the family density of alcoholism on children of alcoholics' (COAs) psychological functioning.Method: A multisite epidemiological study was conducted in 8 Spanish cities, recruiting a total sample of 371 COAs (whose parents were in contact with alcohol treatment centers and accepted to participate in this study) and 147 controls (from schools in the same localities as COAs). Both groups were 6-17 years old and received a comprehensive evaluation of mental disorders (no symptoms, subclinical symptoms or clinical diagnosis for each disorder; according to DSM-IV criteria); alcohol and other substance use (none, occasional, regular and risky consumption); school achievement (low, middle and high) and other academic performance indicators (WISC-R Information and Arithmetic subtests, school support activities and failed subjects and courses). Lastly, several cognitive functions were measured by the WISC-R Similarities, Block Design and Digit Symbol subtests, the Toulouse-Piéron test and the Stroop test. Logistic regression methods were used to compare both groups and a linear regression model was used to determine the influence of the family density of alcoholism. The following confounding variables were controlled for: age, gender, socio-economic status and family cohesion.Results: Children of alcoholics' were twice as likely as controls to present subclinical symptoms and four times more likely than controls to have a definite diagnosis of any mental disorder. More specifically, COAs had a significantly higher risk than controls of attention deficit disorder/hyperactivity, depression, phobias, enuresis and tics. COAs also tended to have more symptoms of generalized anxiety disorder. COAs had worse results on all the cognitive tests used and their risk of low school achievement was nine times higher than that of controls. Family density of alcoholism was significantly related to several psychiatric disorders and to low academic and cognitive performance in these children.Conclusion: Children of alcoholics' whose parents are in contact with treatment centers in Spain constitute a target group for selective prevention, as they have a higher risk of different negative outcomes, which mainly include attention disorders and other cognitive deficits, depression and anxiety. [ABSTRACT FROM AUTHOR]- Published
- 2008
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34. Sermón que predico el Padre Maestro F. Ioseph de la Madre de Dios y Arellano... en la solemne fiesta que se celebró... a la Seraphica Madre y Beata Virgen Teresa de Iesus... a ocho de octubre, de 1617
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José de la Madre de Dios y Arellano (O.C.D.) and Fernández Zambrano, Martín
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Sermones españoles ,Teresa de Jesús, Santa, 1515-1582 - Abstract
Colofón, Inic. grab., Marca tip. y colofón al fin., Enc. Perg., Sign.: [ ]4, B4, B4, D3, [ ]1
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- 1616
35. Los dos estados de Ninive cautiva y libertada : deduzidos del libro de Ionas, Profeta... por el P. F. Ioseph de la Madre de Dios
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José de la Madre de Dios y Arellano (O.C.D.) and Cuesta, Juan de la
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BHR/A-002-219, BHR/A-004-088, (BIB LVL) w-FONDO ANTIGUO, (ES-GrU)b11085307-34cbua_ugr, (OCoLC)933896235, AOP, José de la Madre de Dios y Arellano (O.C.D.), Los dos estados de Ninive cautiva y libertada : deduzidos del libro de Ionas, Profeta... por el P. F. Ioseph de la Madre de Dios..., En Madrid, 40, Marca tip. en port., Esc. calc. en ¶5v
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- 1618
36. Medicina practica de Guadalupe
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Sanz de Dios y Guadalupe, Francisco, fl. ca. 1739 and Fernandez, Domingo, imp.
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Copia digital. Madrid : Ministerio de Cultura. Subdirección General de Coordinación Bibliotecaria, 2006 Sign. : [calderón]-2[calderón]\p4\s, 3[calderón]\p6\s, A-Z\p4\s, 2A-2X\p4\s Port. con orla tip.
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- 1729
37. Medicina practica de Guadalupe su autor Don Francisco Sanz de Dios y Guadalupe ... contiene los tratados siguientes divididos en seis libros. En el primero se trata de las calenturas en general y particular. En el segundo de los afectos de la cabeza. En el tercero de los afectos de pecho. En el quarto de los afectos de estomago è intestinos. En el quinto de los afectos de riñones. En el sexto, y ultimo de los afectos del utero
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Sanz de Dios y Guadalupe, Francisco and Fernández de Arrojo, Domingo
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Medicina ,Enfermedades - Abstract
Port. con doble orla tip., En cabecera de la h. ¶ 2 r. grab. xil. de la Virgen de Guadalupe, Texto a dos columnas, con reclamos, viñetas y letras capitales ornadas, Enc. Perg., Sign.: ¶-¶¶4, ¶¶¶6, A-Z4, Aa-Xx4, Contiene los tratados siguientes divididos en seis libros. En el primero se trata de las calenturas en general y particular. En el segundo de los afectos de la cabeza. En el tercero de los afectos de pecho. En el quarto de los afectos de estomago è intestinos. En el quinto de los afectos de riñones. En el sexto, y ultimo de los afectos del utero
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- 1729
38. Medicina practica de Guadalupe [Texto impreso]
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Sanz de Dios y Guadalupe, Francisco, Fernández de Arroyo, Domingo imp., Sanz de Dios y Guadalupe, Francisco, and Fernández de Arroyo, Domingo imp.
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Contiene los tratados siguientes divididos en seis libros: En el primero se trata de las calenturas en general, y particular. En el segundo los afectos de la cabeza. En el tercero de los afectos del pecho. En el cuarto de los afectos del estómago, è intestinos. En el quinto de los afectos de riñones. En el sexto, y último de los afectos de utero, Contiene los tratados siguientes divididos en seis libros: En el primero se trata de las calenturas en general, y particular. En el segundo los afectos de la cabeza. En el tercero de los afectos del pecho. En el cuarto de los afectos del estómago, è intestinos. En el quinto de los afectos de riñones. En el sexto, y último de los afectos de utero., Aguilar Piñal. Bib. S.XVIII, Sign.: ¶-¶¶⁴, ¶¶¶⁶, A-Z⁴, Aa-Xx⁴, Portada con orla tipográfica, Texto a dos columnas, Grabado xilográfico de Santa María de Guadalupe en recto de h. ¶₂
39. Medicina practica de Guadalupe [Texto impreso]
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Sanz de Dios y Guadalupe, Francisco, Herederos de la viuda de Juan García Infanzón imp., Sanz de Dios y Guadalupe, Francisco, and Herederos de la viuda de Juan García Infanzón imp.
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Aguilar Piñal. Bib. S.XVIII, Sign.: ¶⁶, ¶¶-¶¶¶⁴, A-Z⁴, Aa-Xx⁴, Portada a dos tintas con orla tipográfica, Texto a dos columnas, Grabado xilográfico de Santa María de Guadalupe en recto de h. ¶₂
40. Medicina practica de Guadalupe
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Sanz de Dios y Guadalupe, Francisco and Sanz de Dios y Guadalupe, Francisco
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https://patrimoniodigital.ucm.es/r/thumbnail/736084, https://patrimoniodigital.ucm.es/r/item/5327136619
41. Medicina practica de Guadalupe
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Sanz de Dios y Guadalupe, Francisco and Sanz de Dios y Guadalupe, Francisco
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https://patrimoniodigital.ucm.es/r/thumbnail/733218, https://patrimoniodigital.ucm.es/r/item/5327136646
42. Medicina practica de Guadalupe
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Sanz de Dios y Guadalupe, Francisco and Sanz de Dios y Guadalupe, Francisco
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https://patrimoniodigital.ucm.es/r/thumbnail/709960, https://patrimoniodigital.ucm.es/r/item/5327136664
43. Medicina practica de Guadalupe
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Sanz de Dios y Guadalupe, Francisco and Sanz de Dios y Guadalupe, Francisco
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https://patrimoniodigital.ucm.es/r/thumbnail/697121, https://patrimoniodigital.ucm.es/r/item/5320265212
44. Comedias varias
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Tárrega, Francisco ca. 1554-1602 Cerco de la perseguida Amaltea, Tárrega, Francisco ca. 1554-1602 Cerco de Rodas, Cáncer y Velasco, Jerónimo de 1599?-1655 No hay reino como el de Dios y mártires de Madrid, Moreto, Agustín 1618-1669, Matos Fragoso, Juan de 1608-1689, Solís, Antonio de 1610-1686, Coello, Antonio 1611-1652, Calderón de la Barca, Pedro 1600-1681 El pastor Fido, Monroy y Silva, Cristóbal de 1612-1649 La Sirena del Jordan, San Juan Baptista, Enríquez Gómez, Antonio 1600-1663 Santa Pelagia, Godínez, Felipe 1585-1659 Cautelas son amistades, Moreto, Agustín 1618-1669 Merecer para alcanzar, Moreto, Agustín 1618-1669 Empezar a ser amigos, Pérez de Montalbán, Juan 1602-1638 La desdicha venturosa, Villegas, Francisco de Mas piadoso troyano, Polop y Valdés, Pablo 1655?-1689 Los tres mayores imperios, el cielo, el mar y el abismo, Cañizares, José de 1676-1750 Lo que vale ser devotos de San Antonio de Padua, Tárrega, Francisco ca. 1554-1602 Cerco de la perseguida Amaltea, Tárrega, Francisco ca. 1554-1602 Cerco de Rodas, Cáncer y Velasco, Jerónimo de 1599?-1655 No hay reino como el de Dios y mártires de Madrid, Moreto, Agustín 1618-1669, Matos Fragoso, Juan de 1608-1689, Solís, Antonio de 1610-1686, Coello, Antonio 1611-1652, Calderón de la Barca, Pedro 1600-1681 El pastor Fido, Monroy y Silva, Cristóbal de 1612-1649 La Sirena del Jordan, San Juan Baptista, Enríquez Gómez, Antonio 1600-1663 Santa Pelagia, Godínez, Felipe 1585-1659 Cautelas son amistades, Moreto, Agustín 1618-1669 Merecer para alcanzar, Moreto, Agustín 1618-1669 Empezar a ser amigos, Pérez de Montalbán, Juan 1602-1638 La desdicha venturosa, Villegas, Francisco de Mas piadoso troyano, Polop y Valdés, Pablo 1655?-1689 Los tres mayores imperios, el cielo, el mar y el abismo, and Cañizares, José de 1676-1750 Lo que vale ser devotos de San Antonio de Padua
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Texto con correcciones, V.a. Mss/15184, Mss/16491y Mss/17100 para Dejar un reino por otro; Mss/15408 para El pastor Fido; Mss/17166 para Santa Pelagia; Mss/17302 para La fortuna merecida; y Mss/14940 para El cielo, el mar y el abismo, Loa. Emp.: Por las cumbres de los montes (h. 2)... Fin.: acaba todas las cosas (h. 3). El cerco de la perseguida Amaltea : famosa comedia. Emp.: Gallardamente ha corrido (h. 4)... Fin.: la perseguida Amaltea (h. 26) compuesta por el canónigo Tárrega, poeta valenciano. El Cerco de Rodas : comedia famosa. Emp.: Tanto valor acompaña (h. 28)... Fin.: a Rodas defendido (h. 47v) compuesta por el canónigo Tárrega, poeta valenciano. Dejar un reino por otro : gran comedia. Emp.: Así, traidor de mi agravio (h. 51)... Fin.: de Cáncer, Moreto y Matos (h. 108v) de tres ingenios. El pastor Fido : comedia famosa. Emp.: Piedad, cielos, piedad, que ya no puedo (h. 110)... Fin.: aquí tenga fin dichoso (h. 182v) de tres ingenios, Antonio de Solís, Antonio Coello y Pedro Calderón. La sirena del Jordán : comedia famosa. Emp.: ¿Qué alegres fiestas son éstas? (h. 185)... Fin.: de quien la comedia acaba (h. 215v) de Monroy. Santa Pelagia : comedia famosa. Emp.: En este jardín que gasta (h. 233)... Fin.: de Margarita Pelagia (h. 248) de Fernando de Zarate. La cautela en la amistad y lo que merece un soldado : comedia famosa. Emp.: Reliquia hermosa de Milán ¿quién eres? (h. 249)... Fin.: cautelas son amistades (h. 263) de Agustín Moreto. La fortuna merecida : comedia famosa. Emp.: Preguntador forastero (h. 264)... Fin.: si el humilde le merece (h. 279) de Agustín Moreto. Hacer del contrario amigo : comedia. Emp.: Puesto que el robo ha de ser (h. 280)... Fin.: de sus devotos aplausos (h. 295v) de Agustín Moreto. La desdicha venturosa : comedia famosa. Emp.: ¿En fin te has determinado? (h. 297)... Fin.: o ya, un vítor que la ensalce (h. 318) el doctor Juan Pérez de Montalván. Lo que puede la crianza : comedia. Emp.: Acaba, ponte al momento (h. 321)... Fin.: quien es de miedo valiente (h. 358). El más piadoso troyano : comedia famosa. Emp.: Pague Troya su injusta alevosía (h. 361)... Fin.: el más piadoso troyano (h. 408) de Francisco de Villegas. El mar, el cielo y el abismo : comedia nueva. Em, Loa. Emp.: Por las cumbres de los montes (h. 2)... Fin.: acaba todas las cosas (h. 3). El cerco de la perseguida Amaltea, Paz, Teatro (2ª ed.), Rocamora, Gayangos, Andrés, Gregorio de, La colección de manuscritos del literato Serafín Estébanez Calderón en la Biblioteca Nacional, en Cuadernos para la Investigación de la Literatura Hispánica, Por las cumbres de los montes (h. 2)... acaba todas las cosas (h. 3), Gallardamente ha corrido (h. 4)... la perseguida Amaltea (h. 26), Tanto valor acompaña (h. 28)... a Rodas defendido (h. 47v), Así, traidor de mi agravio (h. 51)... dejar un reino por otro (h. 108v), Piedad, cielos, piedad, que ya no puedo (h. 110)... aquí tenga fin dichoso (h. 182v), ¿Qué alegres fiestas son éstas? (h. 185)... de quien la comedia acaba (h. 215v), En este jardín que gasta (h. 233)... de Margarita Pelagia (h. 248), Reliquia hermosa de Milán ¿quién eres? (h. 249)... cautelas son amistades (h. 263), Preguntador forastero (h. 264)... si el humilde le merece (h. 279), Puesto que el robo ha de ser (h. 280)... de sus devotos aplausos (h. 295v), ¿En fin te has determinado? (h. 297)... o ya, un vítor que la ensalce (h. 318), Acaba, ponte al momento (h. 321)... quien es de miedo valiente (h. 358), Pague Troya su injusta alevosía (h. 361)... el más piadoso troyano (h. 408), Gocemos del día (h. 412v)... de vuestra victoria, un vítor (h. 489v), Viva el Rey don Pedro (h. 491)... dadle un vítor al poeta (h. 546), Pascual de Gayangos, Serafín Estébanez Calderón, Pascual de Gayangos, En blanco las h. 3v, 26v, 48, 50, 70v-71, 90, 127v, 150-155, 183, 200v, 214-215r, 248v, 263v, 279v, 318v-319, 358v-359, 376v, 409, 435v-437, 439, 461v-463, 465, 508v y 528, Dibujos a pluma en las h. 1 y 27
45. Parte treinta y tres de doze comedias famosas de varios autores ...
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Rojas Zorrilla, Francisco de 1607-1648 Los trabajos de Tobías, Rojas Zorrilla, Francisco de 1607-1648 Morir pensando matar, Mira de Amescua, Antonio 1577-1644 Vida y muerte del falso Profeta Mahoma, Rosete Niño, Pedro Mira al fin, Vélez de Guevara, Luis 1579-1644 La nueva ira de Dios, y gran Tamorlán de Persia, Rosete Niño, Pedro Ello es hecho, Jiménez de Enciso, Rodrigo El valiente sevillano : primera parte, Jiménez de Enciso, Rodrigo El valiente sevillano : segunda parte, Vega, Lope de 1562-1635 La victoria de la honra, Vega, Lope de 1562-1635 El buen vecino, Jiménez de Enciso, Diego 1585-1634 Santa Margarita, Jiménez de Enciso, Diego 1585-1634 La mayor hazaña de Carlos V, Macé, Claudio fl. 1641-1654 imp., Sonzonio, Juan fl1635-1650 ed., Rojas Zorrilla, Francisco de 1607-1648 Los trabajos de Tobías, Rojas Zorrilla, Francisco de 1607-1648 Morir pensando matar, Mira de Amescua, Antonio 1577-1644 Vida y muerte del falso Profeta Mahoma, Rosete Niño, Pedro Mira al fin, Vélez de Guevara, Luis 1579-1644 La nueva ira de Dios, y gran Tamorlán de Persia, Rosete Niño, Pedro Ello es hecho, Jiménez de Enciso, Rodrigo El valiente sevillano : primera parte, Jiménez de Enciso, Rodrigo El valiente sevillano : segunda parte, Vega, Lope de 1562-1635 La victoria de la honra, Vega, Lope de 1562-1635 El buen vecino, Jiménez de Enciso, Diego 1585-1634 Santa Margarita, Jiménez de Enciso, Diego 1585-1634 La mayor hazaña de Carlos V, Macé, Claudio fl. 1641-1654 imp., and Sonzonio, Juan fl1635-1650 ed.
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Los trabajos de Tobias / de d. Francisco de Rojas, h. 24 . Morir pensando matar / de d. Francisco de Rojas, h. 25-44 . Vida y muerte del falso profeta Mahoma / de d. Francisco de Rojas, h. 45-68 . Mira al fin / de don Pedro Rosete, h. 69-90 . La nueua ira de Dios y gran Tamorlan de Persia / de Lope de Vega Carpio, h. 91-112 . Ello es hecho / de don Pedro Rosete, h. 113-132 . Primera [-segunda] parte del valiente seuillano / de D. Rodrigo Ximenez de Enziso, h. 133-179 [i.e. 176] . La vitoria por la honra / de Lope de Vega Carpio, h. 181-203 . El buen vezino / de Lope de Vega Carpio, h. 204-221 . Santa Margarita / de D. Diego Ximenez de Enziso, h. 222-238 . La mayor hazaña de Carlos V / de D. Diego Ximenez de Enziso, h. 239-266, Profeti. Diferentes autores, Vida y muerte del falso profeta Mahoma es de Mira de Amescua (Valladares. Bibliografía de Antonio Mira de Amescua, p. 161-163), El gran Tamorlán de Persia se atribuye a Luis Vélez de Guevara, El buen vecino no es de Lope (Morley-Bruerton. Cronología de las comedias de Lope de Vega, p. 426), Existe emisión con pie de imprenta: En Valencia: por Claudio Mace ..., vendese en la misma imprenta, 1642, Marca tipográfica del editor en portada, Sign.: [ ]⁴, A-E⁸, F⁴, G-L⁸, M⁶, N-O⁸, P⁶, Q-R⁸, S⁴, T-Z⁸, Aa⁴, Bb-Cc⁸, Dd⁶, Ee-Ff⁸, Gg², Hh⁸, Ii¹⁰, Kk-Mm⁸, Nn⁴, Errores de foliación: h. 40 por 41, 41 por 42, 42 por 43, 43 por 44, 24 por 49, 150 por 162, desde h. 173 la foliación se sustituye por paginación hasta la h. 181, de 200 pasa a 202, 21 por 215, 234 por 233, repite 235, Texto a dos columnas, Escudo xilográfico heráldico en h. [ ]2v, Viñetas xilográficas ornamentales al comienzo de las comedias y al final de la mayor parte de ellas
46. Medicina practica de Guadalupe [Texto impreso]
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Sanz de Dios y Guadalupe, Francisco, Herederos de la viuda de Juan García Infanzón imp., Sanz de Dios y Guadalupe, Francisco, and Herederos de la viuda de Juan García Infanzón imp.
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Aguilar Piñal. Bib. S.XVIII, Sign.: ¶⁶, ¶¶-¶¶¶⁴, A-Z⁴, Aa-Xx⁴, Portada a dos tintas con orla tipográfica, Texto a dos columnas, Grabado xilográfico de Santa María de Guadalupe en recto de h. ¶₂
47. Medicina practica de Guadalupe [Texto impreso]
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Sanz de Dios y Guadalupe, Francisco, Fernández de Arroyo, Domingo imp., Sanz de Dios y Guadalupe, Francisco, and Fernández de Arroyo, Domingo imp.
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Contiene los tratados siguientes divididos en seis libros: En el primero se trata de las calenturas en general, y particular. En el segundo los afectos de la cabeza. En el tercero de los afectos del pecho. En el cuarto de los afectos del estómago, è intestinos. En el quinto de los afectos de riñones. En el sexto, y último de los afectos de utero, Contiene los tratados siguientes divididos en seis libros: En el primero se trata de las calenturas en general, y particular. En el segundo los afectos de la cabeza. En el tercero de los afectos del pecho. En el cuarto de los afectos del estómago, è intestinos. En el quinto de los afectos de riñones. En el sexto, y último de los afectos de utero., Aguilar Piñal. Bib. S.XVIII, Sign.: ¶-¶¶⁴, ¶¶¶⁶, A-Z⁴, Aa-Xx⁴, Portada con orla tipográfica, Texto a dos columnas, Grabado xilográfico de Santa María de Guadalupe en recto de h. ¶₂
48. Colección de poesías mexicanas, anónimas y de varios autores [Manuscrito]
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Valdés, José S.XIX, Beltrán, José Protasio Coloquio de Nuestra Señora de Guadalupe, González de la Zarza, Juan Antonio Actos de fe, esperanza, amor de Dios y dolor de haberle ofendido, necesarios a todo adulto cristiano con uso de razón para salvarse, Friso de Yebra, Francisco S.XIX, Valdés, José S.XIX, Beltrán, José Protasio Coloquio de Nuestra Señora de Guadalupe, González de la Zarza, Juan Antonio Actos de fe, esperanza, amor de Dios y dolor de haberle ofendido, necesarios a todo adulto cristiano con uso de razón para salvarse, and Friso de Yebra, Francisco S.XIX
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Marcha, 14 septiembre 1821: A las armas valientes indianos / a las armas corred con valor (h. 1-2). A la restauración de la libertad de la América: Llegó ya mexicanos el día / en que viera la patria el albor (h. 2v). Loa. Emp.: Hay América dichosa (h. 3)… Fin.: viva la reina tu amada (h. 9v). Descripción por lo tocante a nuestra América septentrional, del lamentable suceso acaecido a su Sagrada Compañía de Jesús, en los dominios de España, copiada por José Mariano Guzmán, 22 octubre 1841: De junio veinticinco se contaba / y era del Corpus la divina octava (h. 10-17v). Poesía: Miré, admiré, leí / al contemplar atento y cuidadoso (h. 18). La libertad y la tiranía, composición alegórica en celebridad del juramento de la Constitución política de la Monarquía española solemnizado en la ciudad de Toluca, 11 junio 1820: Tristes gemidos, lastimeros ayes / que piedad y consuelo reclamaban (h. 20-22v). Poesía: ¿Más víctimas buscando acaso vienes / en estas soledades apartadas (h. 23). Soneto: ¿Y quién pudiera América dichosa / haber el colmo puesto a tu ventura (h. 24). Poesía satírica contra Antonio López Santana: Quién es el mismo demonio, Antonio / quién es de su patria los azotes, López (h. 25). Efectos útiles de un jubileo y algo de lo bello de la rivera de San Cosme: La sabia omnipotencia / que el orbe rige con alta providencia (h. 26-32v). Versos pronunciados en la mesa de los virreyes José de Iturrigaray y María Inés de Jáuregui, el 1 de junio, en San Agustín de las Cuevas, en la casa de los Condes de Regla. Soneto: Los árboles, las plantas y las flores / la música, el ingenio y la poesía. Octava: Por todo el orbe la fama bulliciosa / da a conocer al jefe esclarecido. Soneto: Juntáronse en los bordos de Helicona / las nueve musas alegres y oficiosas (h. 34v-35). Soneto: Aquí pluma te cuelgo, de esta estaca / a mi triste candil apago el moco (h. 36). Poesía: Quiso Dios dar a México una idea / del alma de su madre soberana (h. 37). Invitación para el funeral de Agustín, Marcha, 14 septiembre 1821: A las armas valientes indianos / a las armas corred con valor (h. 1-2). A la restauración de la libertad de la América: Llegó ya mexicanos el día / en que viera la patria el albor (h. 2v). Loa. Emp.: Hay América dichosa (h. 3)… Fin.: viva la reina tu amada (h. 9v). Descripción por lo tocante a nuestra América septentrional, del lamentable suceso acaecido a su Sagrada Compañía de Jesús, en los dominios de España, copiada por José Mariano Guzmán, 22 octubre 1841: De junio veinticinco se contaba / y era del Corpus la divina octava (h. 10-17v). Poesía: Miré, admiré, leí / al contemplar atento y cuidadoso (h. 18). La libertad y la tiranía, composición alegórica en celebridad del juramento de la Constitución política de la Monarquía española solemnizado en la ciudad de Toluca, 11 junio 1820: Tristes gemidos, lastimeros ayes / que piedad y consuelo reclamaban (h. 20-22v). Poesía: ¿Más víctimas buscando acaso vienes / en estas soledades apartadas (h. 23). Soneto: ¿Y quién pudiera América dichosa / haber el colmo puesto a tu ventura (h. 24). Poesía satírica contra Antonio López Santana: Quién es el mismo demonio, Antonio / quién es de su patria los azotes, López (h. 25). Efectos útiles de un jubileo y algo de lo bello de la rivera de San Cosme: La sabia omnipotencia / que el orbe rige con alta providencia (h. 26-32v). Versos pronunciados en la mesa de los virreyes José de Iturrigaray y María Inés de Jáuregui, el 1 de junio, en San Agustín de las Cuevas, en la casa de los Condes de Regla. Soneto: Los árboles, las plantas y las flores / la música, el ingenio y la poesía. Octava: Por todo el orbe la fama bulliciosa / da a conocer al jefe esclarecido. Soneto: Juntáronse en los bordos de Helicona / las nueve musas alegres y oficiosas (h. 34v-35). Soneto: Aquí pluma te cuelgo, de esta estaca / a mi triste candil apago el moco (h. 36). Poesía: Quiso Dios dar a México una idea / del alma de su madre soberana (h. 37). Invitación para el funeral de Agustín, Paz, América (2ª ed.), Valadés, José C, Historia del pueblo de México, desde sus orígenes hasta nuestros días, México D.F., 1967, Suárez Radillo, Carlos Miguel, El teatro neoclásico y costumbrista hispanoamericano, Madrid, 1984, Raffi-Béroud, Catherine, El Auto Mariano de Fernández de Lizardi: eslabón y símbolo en la cadena de los textos sobre la tradición guadalupana, en Ensayos de literatura europea e hispanoamericana, Félix Menchacatorre (ed.), País Vasco, 1990, Raffi-Béroud, Catherine, En torno al teatro de Fernández de Lizardi, Amsterdam, 1998, González Acosta, Alejandro, Buenas nuevas para los estudiosos: hallazgos bibliográficos mexicanos en Europa y Estados Unidos, en Boletín Millares Carlo, Impacto en América de la expulsión de los jesuitas, en Tres grandes cuestiones de la historia de Iberoamérica: ensayos y monografías, J. Andrés-Gallego (ed.), Madrid, 2005, A las armas valientes indianos / a las armas corred con valor (h. 1), Llegó ya mexicanos el día / en que viera la patria el albor (h. 2v), Hay América dichosa (h. 3)… viva la reina tu amada (h. 9v), De junio veinticinco se contaba / y era del Corpus la divina octava (h. 10), Miré, admiré, leí / al contemplar atento y cuidadoso (h. 18), Tristes gemidos, lastimeros ayes / que piedad y consuelo reclamaban (h. 20), ¿Más víctimas buscando acaso vienes / en estas soledades apartadas (h. 23), ¿Y quién pudiera América dichosa / haber el colmo puesto a tu ventura (h. 24), Quién es el mismo demonio, Antonio / quién es de su patria los azotes, López (h. 25), La sabia omnipotencia / que el orbe rige con alta providencia (h. 26), Los árboles, las plantas y las flores / la música, el ingenio y la poesía (h. 34v), Por todo el orbe la fama bulliciosa / da a conocer al jefe esclarecido (h. 34v-35), Juntáronse en los bordos de Helicona / las nueve musas alegres y oficiosas (h. 35), Aquí pluma te cuelgo, de esta estaca / a mi triste candil apago el moco (h. 36), Quiso Dios dar a México una idea / del alma de su madre soberana (h. 37), Pésame, Jesús mío, verte clavado / en esa cruz, tan gravemente herido (h. 39), Amado Dueño, Redentor Sagrado / a quien con tantas culpas he ofendido (h. 39v), Cristo piadoso, que en la Cruz clavado / el pecho muestras por mi amor herido (h. 40), Jerusalén con fiestas celebraba / de Salomón el templo prodigioso (h. 42), Parece que se lo pagan (h. 43)... nos conceda buen suceso (h. 52v), Mi Jesús, Dios amoroso / a quien tanto yo he injuriado (h. 53), Dios altísimo y Señor / criador de la tierra y cielos (h. 59v), En lucha cruel y homicida / la siempre opresora España (h. 61), De la fortuna al vaivén / ya no puedo más sufrir (h. 62), Europeos mal nos tratáis / a este criollismo infeliz (h. 63), Cuando a Cristo lo prendieron / disque hay papeles que dicen (h. 64), Señor Licenciado amigo / pues que no puedo ir a verlo (h. 64v), Es posible cruel fortuna / que me has privado de un modo (h. 65), Mutiladas las h. 41 y 51, deteriorada la h. 60 y en blanco las h. 19, 33 y 58, Dibujo a plumilla en la h. 39v
49. Verdad, metafísica y epistemología. Observaciones sobre la neutralidad de la verdad
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Forero Mora, José Andrés; Corporación Universitaria Minuto de Dios y Universidad de los Andes and Forero Mora, José Andrés; Corporación Universitaria Minuto de Dios y Universidad de los Andes
- Abstract
El presente texto pretende mostrar que la verdad es neutral con respecto a la metafísica y a la epistemología, esto es, que para hacer un análisis satisfactorio de la manera como cotidianamente usamos el discurso de verdad no es necesario aludir a la naturaleza del mundo ni a la naturaleza de nuestras capacidades epistémicas. Para esto, en primera instancia se explicitan las intuiciones de sentido común que parecen acercar la verdad a la metafísica o a la epistemología (sección 1); posteriormente, se analiza la función que el predicado «es verdadero» cumple dentro de nuestro lenguaje natural (sección 2); por último, con base en este análisis, se retoman las intuiciones mencionadas con el fin de indagar por su carácter intuitivo y la supuesta relación con la metafísica y la epistemología.
50. Observaciones a la alegacion de los Padres de la Casa del Noviciado de la Compañia de Jesus, y Convento del Venerable Anton Martin de esta Corte, sobre concordia de Esquivias
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Suarez de Zayas, Juan, Noviciado y Casa de Probacion de la Compañia de Jesús (Madrid), Convento Hospital de Nuestra Señora del Amor de Dios y Venerable Padre Antón Martín (Madrid), Catedral Primada de Toledo. Cabildo, Suarez de Zayas, Juan, Noviciado y Casa de Probacion de la Compañia de Jesús (Madrid), Convento Hospital de Nuestra Señora del Amor de Dios y Venerable Padre Antón Martín (Madrid), and Catedral Primada de Toledo. Cabildo
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Autor consta en fin de texto., Probablemente impreso en la primera mitad del S. XVIII., Sign.: A\p4\s.
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