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4. Correction: Variation of virulence of five Aspergillus fumigatus isolates in four different infection models

Author

Keizer, E M, Valdes, I D, Forn-Cuni, G, Klijn, E, Meijer, A H, Hillmann, F, Wösten, H A B, de Cock, H, Molecular Microbiology, and Sub Molecular Microbiology

Subjects
General
Abstract

The sixth author’s name is spelled incorrectly. The correct name is: F. Hillmann. The correct citation is: Keizer EM, Valdes ID, Forn-Cuni G, Klijn E, Meijer AH, Hillmann F, et al. (2021) Variation of virulence of five Aspergillus fumigatus isolates in four different infection models. PLoS ONE 16(7): e0252948. https://doi.org/10.1371/journal.pone.0252948

Published
2021

5. Variation of virulence of five Aspergillus fumigatus isolates in four different infection models

Author

Keizer, E M, Valdes, I D, Forn-Cuni, G, Klijn, E, Meijer, A H, Hillman, F, Wösten, H A B, de Cock, H, Sub Molecular Microbiology, Molecular Microbiology, Sub Molecular Microbiology, and Molecular Microbiology

Subjects
Life Cycles, Embryology, Single Nucleotide Polymorphisms, Aspergillosis, Pathology and Laboratory Medicine, Epithelium, Conidium, Aspergillus fumigatus, Larvae, Animal Cells, Fungal Reproduction, Medicine and Health Sciences, Fungal Spore Germination, Amoebas, Zebrafish, Fungal Pathogens, Protozoans, 0303 health sciences, Multidisciplinary, Strain (chemistry), Virulence, Eukaryota, Animal Models, 3. Good health, Phenotype, Aspergillus, Aspergillus Fumigatus, Experimental Organism Systems, Fungal Molds, Medical Microbiology, Osteichthyes, Vertebrates, Medicine, Allergic bronchopulmonary aspergillosis, Pathogens, Cellular Types, Anatomy, Research Article, Science, Mycology, Biology, Research and Analysis Methods, Microbiology, Amoeba (operating system), 03 medical and health sciences, Dogs, Model Organisms, medicine, Genetics, Animals, General, Gene, Microbial Pathogens, 030304 developmental biology, 030306 microbiology, Embryos, Organisms, Fungi, Correction, Biology and Life Sciences, Epithelial Cells, Cell Biology, medicine.disease, biology.organism_classification, Fish, Biological Tissue, Mutation, Animal Studies, Zoology, Developmental Biology
Abstract

Conidia of Aspergillus fumigatus are inhaled by humans on daily basis. As a consequence, these conidia can cause infections that differ in severity ranging from allergic bronchopulmonary aspergillosis to invasive aspergillosis. In this study we compared virulence of five A. fumigatus isolates in four different infection models to address the predictive value of different model systems. Two of the A. fumigatus strains were isolated from dogs with a non-invasive sino-nasal aspergillosis (DTO271-B5 and DTO303-F3), while three strains were isolated from human patients with invasive aspergillosis (Af293, ATCC46645 and CEA10). Infection models used encompassed cultured type II A549 lung epithelial cells, Protostelium aurantium amoeba, Galleria melonella larvae and zebrafish embryos. No major differences in virulence between these five strains were observed in the lung epithelial cell model. In contrast, strain ATCC46645 was most virulent in the amoeba and zebrafish model, whereas it was much less virulent in the Galleria infection model. DTO303-F3 was most virulent in the latter model. In general, reference strain Af293 was less virulent as compared to the other strains. Genome sequence analysis showed that this latter strain differed from the other four strains in 136 SNPs in virulence-related genes. Together, our results show that virulence of individual A. fumigatus strains show significant differences between infection models. We conclude that the predictive value of different model systems varies since the relative virulence across fungal strains does not hold up across different infection model systems.

Published
2021

14. Profiling of volatile organic compounds produced by clinical Aspergillus isolates using gas chromatography-mass spectrometry

Author

Gerritsen, M G, Brinkman, P, Escobar Salazar, Natalia, Bos, L D, de Heer, K, Meijer, M, Janssen, H-G, de Cock, H, Wösten, H A B, Visser, C.E., van Oers, M H J, Sterk, P J, Sub Molecular Microbiology, Molecular Microbiology, Westerdijk Fungal Biodiversity Institute, Westerdijk Fungal Biodiversity Institute - Food and Indoor Mycology, Graduate School, Pulmonology, Other departments, Medical Microbiology and Infection Prevention, ARD - Amsterdam Reproduction and Development, ACS - Heart failure & arrhythmias, Supramolecular Separations (HIMS, FNWI), Sub Molecular Microbiology, and Molecular Microbiology

Subjects
0301 basic medicine, 030106 microbiology, Conidiation, Mass spectrometry, Aspergillosis, Gas Chromatography-Mass Spectrometry, 03 medical and health sciences, In vivo, Taverne, medicine, Humans, Invasive Pulmonary Aspergillosis, Aspergillus, Volatile Organic Compounds, Chromatography, biology, Chemistry, invasive pulmonary aspergillosis, exhaled breath analysis, General Medicine, Invasive pulmonary aspergillosis, biology.organism_classification, medicine.disease, gas chromatography-mass spectrometry, 030104 developmental biology, Infectious Diseases, Breath Tests, headspace analysis, Gas chromatography, Gas chromatography–mass spectrometry
Abstract

Volatile organic compounds (VOCs) in exhaled breath may identify the presence of invasive pulmonary aspergillosis. We aimed to detect VOC profiles emitted by in vitro cultured, clinical Aspergillus isolates using gas chromatography–mass spectrometry (GC-MS). Three clinical Aspergillus isolates and a reference strain were cultured while conidiation was prevented. Headspace samples were analyzed using a standardized method. Breath samples of patients from which the cultures were obtained were checked for the presence of the VOCs found in vitro. Each Aspergillus isolate produced a distinct VOC profile. These profiles could not be confirmed in exhaled breath in vivo.

Published
2016

17. Congenital lobar emphysema in a kitten

Author

Blonk, M., primary, Van de Maele, I., additional, Combes, A., additional, Stablay, B., additional, De Cock, H., additional, Polis, I., additional, Rybachuk, G., additional, and de Rooster, H., additional

Published
2017
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23. Portal vein hypoplasia in dogs

Author

Devriendt, N., primary, Or, M., additional, Paepe, D., additional, Vandermeulen, E., additional, Hesta, M., additional, De Cock, H. E. V., additional, and De Rooster, H., additional

Published
2014
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25. Titanium mesh reconstruction of a dog's cranium after multilobular osteochondrosarcoma resection.

Author

de Casterlé, A. Dierckx, Van Goethem, B., Kitshoff, A., Bhatti, S. F. M., Gielen, I., Bosmans, T., De Cock, H., and de Rooster, H.

Subjects
SKULL diseases, DOG diseases, VETERINARY therapeutics, SKULL surgery, DOG surgery, METAL mesh
Abstract

Copyright of Vlaams Diergeneeskundig Tijdschrift is the property of Ghent University, Faculty of Veterinary Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2017
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34. Export and assembly of bacterial outer membrane proteins

Author

Jan Tommassen, Struyvé M, and de Cock H

Subjects
Bacteria, Porins, Biological Transport, General Medicine, Biology, biology.organism_classification, medicine.disease_cause, Microbiology, Porina, Cell biology, Biochemistry, Bacterial Outer Membrane Proteins, Porin, medicine, Outer membrane efflux proteins, Virulence-related outer membrane protein family, Bacterial outer membrane, Molecular Biology, Escherichia coli
Published
1992

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