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4,683 results on '"De Clercq, E"'

1. Laser cooling in a chip-scale platform

Author

McGilligan, J. P., Moore, K. R., Dellis, A., Martinez, G. D., de Clercq, E., Griffin, P. F., Arnold, A. S., Riis, E., Boudot, R., and Kitching, J.

Subjects
Physics - Atomic Physics, Physics - Instrumentation and Detectors, Physics - Optics
Abstract

Chip-scale atomic devices built around micro-fabricated alkali vapor cells are at the forefront of compact metrology and atomic sensors. We demonstrate a micro-fabricated vapor cell that is actively-pumped to ultra-high-vacuum (UHV) to achieve laser cooling. A grating magneto optical trap (GMOT) is incorporated with the 4 mm-thick Si/glass vacuum cell to demonstrate the feasibility of a fully-miniaturized laser cooling platform. A two-step optical excitation process in rubidium is used to overcome surface-scatter limitations to the GMOT imaging. The unambiguous miniaturization and form-customizability made available with micro-fabricated UHV cells provide a promising platform for future compact cold-atom sensors., Comment: 5 pages, 3 figures

Published
2020
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2. Power stabilization of a diode laser with an acousto-optic modulator

Author

Tricot, F., Phung, D. H., Lours, M., Guerandel, S., and de Clercq, E.

Subjects
Physics - Applied Physics
Abstract

Laser power fluctuations can significantly reduce the device performances in various applications. High frequency fluctuations impact the signal-to-noise ratio, while slow variations can reduce the device repeatability or accuracy. Here we report experimental investigations on the power stabilization of a diode laser with an acousto-optic modulator. In the frequency domain the relative power noise is reduced at the level of $2.2\times 10^{-8}$ Hz$^{-1/2}$ in the range 1-100 kHz. The slow variations are studied in the time domain. The relative Allan standard deviation is measured at the level of $6\times 10^{-7}$ at 100 s averaging time. Above 100 s the instability increases and reaches $2 \times 10^{-6}$ at 10 000 s.

Published
2018
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3. Quantum engineering of atomic phase-shifts in optical clocks

Author

Zanon-Willette, T., Almonacil, S., de Clercq, E., Ludlow, A. D., and Arimondo, E.

Subjects
Physics - Atomic Physics, Quantum Physics
Abstract

Quantum engineering of time-separated Raman laser pulses in three-level systems is presented to produce an ultra-narrow optical transition in bosonic alkali-earth clocks free from light shifts and with a significantly reduced sensitivity to laser parameter fluctuations. Based on a quantum artificial complex-wave-function analytical model, and supported by a full density matrix simulation including a possible residual effect of spontaneous emission from the intermediate state, atomic phase-shifts associated to Ramsey and Hyper-Ramsey two-photon spectroscopy in optical clocks are derived. Various common-mode Raman frequency detunings are found where the frequency shifts from off-resonant states are canceled, while strongly reducing their uncertainties at the 10$^{-18}$ level of accuracy., Comment: accepted for publication in PRA

Published
2014
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4. Danoprevir for the Treatment of Hepatitis C Virus Infection: Design, Development, and Place in Therapy

Author

Miao M, Jing X, De Clercq E, and Li G

Subjects
danoprevir, itmn-191, r7227, hcv ns3/4a inhibitor, hcv genotype, Therapeutics. Pharmacology, RM1-950
Abstract

Miao Miao,1 Xixi Jing,1 Erik De Clercq,2 Guangdi Li1 1Hunan Provincial Key Laboratory of Clinical Epidemiology, Xiangya School of Public Health, Central South University, Changsha 410078, People’s Republic of China; 2Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, Leuven 3000, BelgiumCorrespondence: Guangdi Li Email liguangdi.research@gmail.comAbstract: On June 8, 2018, an NS3/4A protease inhibitor called danoprevir was approved in China to treat the infections of HCV genotype (GT) 1b – the most common HCV genotype worldwide. Based on phase 2 and 3 clinical trials, the 12-week regimen of ritonavir-boosted danoprevir (danoprevir/r) plus peginterferon alpha-2a and ribavirin offered 97.1% (200/206) of sustained virologic response at post-treatment week 12 (SVR12) in treatment-naïve non-cirrhotic patients infected with HCV genotype 1b. Adverse events such as anemia, fatigue, fever, and headache were associated with the inclusion of peginterferon alpha-2a and ribavirin in the danoprevir-based regimen. Moreover, drug resistance to danoprevir could be traced to amino acid substitutions (Q80K/R, R155K, D168A/E/H/N/T/V) near the drug-binding pocket of HCV NS3 protease. Despite its approval, the clinical use of danoprevir is currently limited to its combination with peginterferon alpha-2a and ribavirin, thereby driving its development towards interferon-free, ribavirin-free regimens with improved tolerability and adherence. In the foreseeable future, pan-genotypic direct-acting antivirals with better clinical efficacy and less adverse events will be available to treat HCV infections worldwide.Keywords: danoprevir, ITMN-191, R7227, HCV NS3/4A inhibitor, HCV genotype

Published
2020

37. Antiviral activity of Rwandan medicinal plants against human immunodeficiency virus type-1 (HIV-1)

Author

Cos, P., Hermans, N., De Bruyne, T., Apers, S., Sindambiwe, J.B., Witvrouw, M., De Clercq, E., Berghe, D. Vanden, Pieters, L., and Vlietinck, A.J.

Abstract

Summary Selected plants used in Rwandan traditional medicine for the treatment of infections and/or rheumatoid diseases were investigated for antiviral activity in vitro against human immunodeficiency virus type-1 (HIV-1). Of [...]

Published
2002

42. Laser cooling in a chip-scale platform

Author

McGilligan, J. P., primary, Moore, K. R., additional, Dellis, A., additional, Martinez, G. D., additional, de Clercq, E., additional, Griffin, P. F., additional, Arnold, A. S., additional, Riis, E., additional, Boudot, R., additional, and Kitching, J., additional

Published
2020
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47. Phenotypic assays and sequencing are less sensitive than point mutation assays for detection of resistance in mixed HIV-1 genotypic populations

Author

Van Laethem, K., Van Vaerenbergh, K., Schmit, J.-C., Sprecher, S., Hermans, P., De Vroey, V., Schuurman, R., Harrer, T., Witvrouw, M., Van Wijngaerden, E., Stuyver, L., Van Ranst, M., Desmyter, J., De Clercq, E., and Vandamme, A.-M.

Subjects
Drug resistance in microorganisms -- Identification and classification, HIV (Viruses) -- Genetic aspects, Health
Abstract

The 151 and 215 amplification refractory mutation system (ARMS) is more accurate than other tests in detecting drug resistance in the virus that causes AIDS. ARMS was compared with T7 sequencing, cycle sequencing, the line probe assay (LiPA) HIV-1 RT test, and the recombinant virus assay (RVA).

Published
1999

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