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3. [Stereospecificity of hypothalamo-hypophysial dopamine receptors involved in the control of prolactin secretion in normal man: effects of sulpiride stereoisomers].

Author

Benfenati F, De Camillis E, Cortelli P, and Orlandi F

Subjects
Adult, Humans, Male, Prolactin blood, Receptors, Dopamine drug effects, Reference Values, Stereoisomerism, Structure-Activity Relationship, Prolactin metabolism, Receptors, Dopamine physiology, Sulpiride pharmacology
Abstract

The sterical requirements of dopamine (DA) receptors involved in the control of prolactin (PL) secretion have been analyzed by studying the effects of the administration of d- and l-sulpiride (25 mg i.v.) on PL serum levels in five normal male volunteers. Both d- and l-sulpiride cause a remarkable rise in PL serum levels, the only difference between the two drugs being the lower decay rate of hormone levels after the l-isomer. The results obtained are discussed in the frame of a possible low steric selectivity of DA receptors controlling PL secretion in the hyposthalamo-pituitary axis.

Published
1980

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