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Your search keyword '"De Caluwe, Diane"' showing total 10 results
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10 results on '"De Caluwe, Diane"'

3. The impact of trisomy 21 on epidemiology, management, and outcomes of congenital duodenal obstruction: a population-based study

Author

Bethell, George S., Long, Anna-May, Knight, Marian, Hall, Nigel J., Jones, Abigail, Aslam, Adil, Mortell, Alan, McCabe, Amanda, Ross, Andrew, Harris, Anna, Lawson, Anne, Kelay, Arun, Abhyankar, Aruna, Rajimwale, Ashok, Bandi, Ashwath, Saeed, Atif, Eradi, Bala, Sharif, Baqer, MacCormack, Brian, Pardy, Caroline, Ridd, Catherine, Jones, Ceri, Nicoara, Cezar, Driver, Chris, Parsons, Chris, Kwok, Chun-Sui, Rees, Clare, Skerritt, Clare, Magnie, Damian, Aronson, Dan, Marshall, David, Deacy, Dawn, Banerjee, Debasish, De Caluwe, Diane, Kufeji, Dorothy, Cusick, Eleri, O’Connor, Elizabeth, Bough, Georgina, Racheva, Gergana, Murthi, Govind, Ghattaura, Harmit, Patel, Hetal, Jones, Ian, Sugarman, Ian, Njere, Ike, Jester, Ingo, Durell, Jonathan, Davidson, Joseph, Sloan, Keren, Cao, Kevin, Elmalik, Khalid, Smith, Lee, Nellihela, Leel, Lopes, Tullie, Lucinda, Henderson, Lucy, Kakade, Madhavi, Haneef, Maryam, Matcovici, Melania, Dawrant, Michael, Horridue, Michelle, Soares-Oliveira, Miguel, Doyle, Miriam, Shalaby, Mohamed, Allan, Morven, Burdell, Oliver, Charlesworth, Paul, Johnson, Paul, Halim, Rahman, Hill, Richard, Peeraully, Riyad, Cresner, Rosie, Craigie, Ross, Gupta, Samir, Motiwale, Sandeep, Besarovic, Sanja, Paramalingam, Saravanakumar, Marven, Sean, Patel, Shailesh, Sharif, Shazia, Naqvi, Shehryer, Clarke, Simon, Kenny, Simon, Eriksson, Sofia, Payne, Susan, Tyraskis, Thanos, Tsang, Thomas, Bradnock, Tim, Calvert, William, Patel, Yatin, Bethell, George S. [0000-0002-1302-0735], and Apollo - University of Cambridge Repository

Subjects
Trisomy 21, Duodenal atresia, Down syndrome, Congenital cardiac disease, Original Article, Duodenal stenosis
Abstract

Purpose: Congenital duodenal obstruction (CDO) is associated with trisomy 21 (T21), or Down’s syndrome, in around a third of infants. The aim of this study was to explore the impact of T21 on the epidemiology, management, and outcomes of infants with CDO. Methods: Data were prospectively collected from specialist neonatal surgical centres in the United Kingdom over a 12 month period from March 2016 using established population-based methodology for all babies with CDO. Infants with T21 were compared to those without any chromosomal anomaly. Results: Of 102 infants with CDO that underwent operative repair, T21 was present in 33 [32% (95% CI 23–41%)] babies. Cardiac anomalies were more common in those with T21 compared to those without a chromosomal anomaly (91 vs 17%, p < 0.001), whereas associated gastrointestinal anomalies were less common in infants with T21 (3 vs 12%, p = 0.03). Surgical management was not influenced by T21. Time to achieve full enteral feed, need for repeat related surgery, and mortality were similar between groups. Infants with T21 had a longer median initial inpatient stay (23 vs 16.5 days, p = 0.02). Conclusions: Infants with T21 have a higher incidence of cardiac anomalies and a longer initial inpatient stay; however, it does not change CDO management or outcomes. This information is important for prenatal and postnatal counselling of parents of infants with CDO and T21.

Published
2020
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10. Does thoracoscopic congenital diaphragmatic hernia repair cause a significant intraoperative acidosis when compared to an open abdominal approach?

Author

Fishman JR, Blackburn SC, Jones NJ, Madden N, De Caluwe D, Haddad MJ, and Clarke SA

Subjects
Abnormalities, Multiple, Acidosis blood, Carbon Dioxide administration & dosage, Carbon Dioxide blood, Carbon Dioxide pharmacokinetics, Hernias, Diaphragmatic, Congenital, Humans, Infant, Newborn, Insufflation, Intraoperative Complications blood, Oxygen blood, Pneumothorax, Artificial adverse effects, Postoperative Complications epidemiology, Prospective Studies, Recurrence, Retrospective Studies, Thoracoscopy statistics & numerical data, Acidosis etiology, Hernia, Diaphragmatic surgery, Intraoperative Complications etiology, Laparotomy statistics & numerical data, Thoracoscopy adverse effects
Abstract

Purpose: Thoracoscopic congenital diaphragmatic hernia (CDH) repair is increasingly reported. A significant intraoperative acidosis secondary to the pneumocarbia, as well as an increased recurrence rate, are possible concerns. Our aim was to review our early experience of the technique., Methods: A prospective and retrospective data collection was carried out on all patients undergoing either an open or thoracoscopic CDH repair for a 4-year period. Preoperative blood gas values were identified at various stages of the operative procedure. A pH of 7.2 was considered to be a significant acidosis. The duration of surgery, complications, and recurrence rates were also recorded. Data were analyzed using the Mann-Whitney U test, and a P value of .05 or less was considered significant., Results: Twenty-two patients were included. One death occurred before surgery. Twelve patients underwent thoracoscopic repair (8 neonatal), and 9 underwent open repair (8 neonatal). There were 9 left-sided defects in the thoracoscopic group and 9 in the open group. Operative time was longer in the thoracoscopic group compared to the open group (median, 135 vs 93.5 minutes; P = .02). Neonates undergoing thoracoscopic repair were heavier compared to the open group (median, 3.9 vs 2.9 kg; P = .05), and their preoperative requirements for ventilation and inotropes were comparable. However, the association between those patients who required preoperative inotropes and those who required a patch repair was statistically significant P = .03. Two patients in each group developed an intraoperative acidosis. A further patient in the thoracoscopic group had a severe acidosis present at the beginning of surgery. There was no statistical difference in pH values or recurrence rate between the 2 groups. All recurrences were in patients requiring patch repairs. No postoperative mortality occurred., Conclusions: We present our early experience of thoracoscopic CDH repair. Our results from thoracoscopic repair appear similar to the open procedure performed over the same period. No clear difference in intraoperative pH or recurrence rate has been demonstrated in our series. There is a need for a multicenter prospective study to establish the longer term outcome of this technique., (Copyright © 2011 Elsevier Inc. All rights reserved.)

Published
2011
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