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3. Providing First Aid to People Experiencing Mental Health Problems: Development of Evidence-Based Guidance Materials for Laypeople

Author

Stroobants, Stijn, Dockx, Kim, Scheers, Hans, Borra, Vere, De Brier, Niels, Verlinden, Sarah, Lauwers, Karen, Vandekerckhove, Philippe, and De Buck, Emmy

Subjects
communication, laypeople education, Evidence-Based Practice, mental health
Abstract

Background: Family and friends are particularly well placed to recognize early signs of mental health problems, provide initial support, and refer to professional help if needed. This project aimed to develop evidence-based guidance materials for laypeople on how to provide help to people experiencing mental health problems, adapted to the context of Flanders, Belgium. Methods: We performed a systematic literature review for 12 different mental health topics, focusing on communicative support interventions feasible to be performed by laypeople. Systematic literature searches were conducted in MEDLINE, Embase, and PsycNET (October 2018). One reviewer per topic conducted data extraction and methodological quality assessment using the GRADE (Grading of Recommendations, Assessment, Development and Evaluations) methodology. The evidence was used to develop a draft manual, which was presented to a multidisciplinary expert panel involving both content experts (n = 10) and mental health peer workers in training (all people with lived experience) (n = 6). Results: Included studies involved 15 experimental and 75 observational studies, leading to 58 evidence conclusions on communicative interventions, risk factors or protective factors, and their relationship to mental health outcomes. The certainty of the evidence was very low for the majority of the evidence conclusions (84.5%), highlighting the need for expert and stakeholder input to inform practical recommendations. Scientific evidence and expert input were used to formulate 33 individual actions on how to provide first aid to people experiencing mental health problems. The recommendations were made available to laypeople via a guidance manual and a mobile application. Conclusions: Input from the scientific literature and the expert panel were essential to obtain evidence-based guidance materials that were meaningful for practice in a Flemish context., International Journal of First Aid Education, Vol. 6 No. 1 (2023)

Published
2023
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4. Evidence summaries per mental health topic

Author

Stroobants, Stijn, Dockx, Kim, Scheers, Hans, Borra, Vere, De Brier, Niels, Verlinden, Sarah, Lauwers, Karen, Vandekerckhove, Philippe, and De Buck, Emmy

Subjects
communication, laypeople education, Evidence-Based Practice, mental health
Published
2023
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5. PRISMA checklist

Author

Stroobants, Stijn, Dockx, Kim, Scheers, Hans, Borra, Vere, De Brier, Niels, Verlinden, Sarah, Lauwers, Karen, Vandekerckhove, Philippe, and De Buck, Emmy

Subjects
communication, laypeople education, Evidence-Based Practice, mental health
Published
2023
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6. Narrative description of evidence conclusions

Author

Stroobants, Stijn, Dockx, Kim, Scheers, Hans, Borra, Vere, De Brier, Niels, Verlinden, Sarah, Lauwers, Karen, Vandekerckhove, Philippe, and De Buck, Emmy

Subjects
communication, laypeople education, Evidence-Based Practice, mental health
Published
2023
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7. Search strategy for systematic literature search

Author

Stroobants, Stijn, Dockx, Kim, Scheers, Hans, Borra, Vere, De Brier, Niels, Verlinden, Sarah, Lauwers, Karen, Vandekerckhove, Philippe, and De Buck, Emmy

Subjects
communication, laypeople education, Evidence-Based Practice, mental health
Published
2023
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8. Prevalence and associated risk factors of HIV infections in a representative transgender and non-binary population in Flanders and Brussels (Belgium): Protocol for a community-based, cross-sectional study using time-location sampling

Author

De Brier, Niels, primary, Van Schuylenbergh, Judith, additional, Van Remoortel, Hans, additional, Van den Bossche, Dorien, additional, Fieuws, Steffen, additional, Molenberghs, Geert, additional, De Buck, Emmy, additional, T’Sjoen, Guy, additional, Compernolle, Veerle, additional, Platteau, Tom, additional, and Motmans, Joz, additional

Published
2022
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9. 2021 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations: Summary From the Basic Life Support; Advanced Life Support; Neonatal Life Support; Education, Implementation, and Teams; First Aid Task Forces; and the COVID-19 Working Group

Author

Wyckoff, Myra H., primary, Singletary, Eunice M., additional, Soar, Jasmeet, additional, Olasveengen, Theresa M., additional, Greif, Robert, additional, Liley, Helen G., additional, Zideman, David, additional, Bhanji, Farhan, additional, Andersen, Lars W., additional, Avis, Suzanne R., additional, Aziz, Khalid, additional, Bendall, Jason C., additional, Berry, David C., additional, Borra, Vere, additional, Böttiger, Bernd W., additional, Bradley, Richard, additional, Bray, Janet E., additional, Breckwoldt, Jan, additional, Carlson, Jestin N., additional, Cassan, Pascal, additional, Castrén, Maaret, additional, Chang, Wei-Tien, additional, Charlton, Nathan P., additional, Cheng, Adam, additional, Chung, Sung Phil, additional, Considine, Julie, additional, Costa-Nobre, Daniela T., additional, Couper, Keith, additional, Dainty, Katie N., additional, Davis, Peter G., additional, de Almeida, Maria Fernanda, additional, de Caen, Allan R., additional, de Paiva, Edison F., additional, Deakin, Charles D., additional, Djärv, Therese, additional, Douma, Matthew J., additional, Drennan, Ian R., additional, Duff, Jonathan P., additional, Eastwood, Kathryn J., additional, El-Naggar, Walid, additional, Epstein, Jonathan L., additional, Escalante, Raffo, additional, Fabres, Jorge G., additional, Fawke, Joe, additional, Finn, Judith C., additional, Foglia, Elizabeth E., additional, Folke, Fredrik, additional, Freeman, Karoline, additional, Gilfoyle, Elaine, additional, Goolsby, Craig A., additional, Grove, Amy, additional, Guinsburg, Ruth, additional, Hatanaka, Tetsuo, additional, Hazinski, Mary Fran, additional, Heriot, George S., additional, Hirsch, Karen G., additional, Holmberg, Mathias J., additional, Hosono, Shigeharu, additional, Hsieh, Ming-Ju, additional, Hung, Kevin K.C., additional, Hsu, Cindy H., additional, Ikeyama, Takanari, additional, Isayama, Tetsuya, additional, Kapadia, Vishal S., additional, Kawakami, Mandira Daripa, additional, Kim, Han-Suk, additional, Kloeck, David A., additional, Kudenchuk, Peter J., additional, Lagina, Anthony T., additional, Lauridsen, Kasper G., additional, Lavonas, Eric J., additional, Lockey, Andrew S., additional, Malta Hansen, Carolina, additional, Markenson, David, additional, Matsuyama, Tasuku, additional, McKinlay, Christopher J.D., additional, Mehrabian, Amin, additional, Merchant, Raina M., additional, Meyran, Daniel, additional, Morley, Peter T., additional, Morrison, Laurie J., additional, Nation, Kevin J., additional, Nemeth, Michael, additional, Neumar, Robert W., additional, Nicholson, Tonia, additional, Niermeyer, Susan, additional, Nikolaou, Nikolaos, additional, Nishiyama, Chika, additional, O’Neil, Brian J., additional, Orkin, Aaron M., additional, Osemeke, Osokogu, additional, Parr, Michael J., additional, Patocka, Catherine, additional, Pellegrino, Jeffrey L., additional, Perkins, Gavin D., additional, Perlman, Jeffrey M., additional, Rabi, Yacov, additional, Reynolds, Joshua C., additional, Ristagno, Giuseppe, additional, Roehr, Charles C., additional, Sakamoto, Tetsuya, additional, Sandroni, Claudio, additional, Sawyer, Taylor, additional, Schmölzer, Georg M., additional, Schnaubelt, Sebastian, additional, Semeraro, Federico, additional, Skrifvars, Markus B., additional, Smith, Christopher M., additional, Smyth, Michael A., additional, Soll, Roger F., additional, Sugiura, Takahiro, additional, Taylor-Phillips, Sian, additional, Trevisanuto, Daniele, additional, Vaillancourt, Christian, additional, Wang, Tzong-Luen, additional, Weiner, Gary M., additional, Welsford, Michelle, additional, Wigginton, Jane, additional, Wyllie, Jonathan P., additional, Yeung, Joyce, additional, Nolan, Jerry P., additional, Berg, Katherine M., additional, Abelairas-Gómez, Cristian, additional, Barcala-Furelos, Roberto, additional, Beerman, Stephen B., additional, Bierens, Joost, additional, Cacciola, Sofia, additional, Cellini, Jacqueline, additional, Claesson, Andreas, additional, Court, Rachael, additional, D’Arrigo, Sonia, additional, De Brier, Niels, additional, Dunne, Cody L., additional, Elsenga, Hylmar E., additional, Johnson, Samantha, additional, Kleven, Gunn, additional, Maconochie, Ian, additional, Mecrow, Tom, additional, Morgan, Patrick, additional, Otto, Quentin, additional, Palmieri, Tina L., additional, Parnia, Sam, additional, Pawar, Rahul, additional, Pereira, João, additional, Rudd, Sarah, additional, Scapigliati, Andrea, additional, Schmidt, Andrew, additional, Seesink, Jeroen, additional, Sempsrott, Justin R., additional, Szpilman, David, additional, Warner, David S., additional, Webber, Jonathon B., additional, and West, Rebecca L, additional

Published
2022
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10. 2021 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations

Author

Wyckoff, Myra H., primary, Singletary, Eunice M., additional, Soar, Jasmeet, additional, Olasveengen, Theresa M., additional, Greif, Robert, additional, Liley, Helen G., additional, Zideman, David, additional, Bhanji, Farhan, additional, Andersen, Lars W., additional, Avis, Suzanne R., additional, Aziz, Khalid, additional, Bendall, Jason C., additional, Berry, David C., additional, Borra, Vere, additional, Böttiger, Bernd W., additional, Bradley, Richard, additional, Bray, Janet E., additional, Breckwoldt, Jan, additional, Carlson, Jestin N., additional, Cassan, Pascal, additional, Castrén, Maaret, additional, Chang, Wei-Tien, additional, Charlton, Nathan P., additional, Cheng, Adam, additional, Chung, Sung Phil, additional, Considine, Julie, additional, Costa-Nobre, Daniela T., additional, Couper, Keith, additional, Dainty, Katie N., additional, Davis, Peter G., additional, de Almeida, Maria Fernanda, additional, de Caen, Allan R., additional, de Paiva, Edison F., additional, Deakin, Charles D., additional, Djärv, Therese, additional, Douma, Matthew J., additional, Drennan, Ian R., additional, Duff, Jonathan P., additional, Eastwood, Kathryn J., additional, El-Naggar, Walid, additional, Epstein, Jonathan L., additional, Escalante, Raffo, additional, Fabres, Jorge G., additional, Fawke, Joe, additional, Finn, Judith C., additional, Foglia, Elizabeth E., additional, Folke, Fredrik, additional, Freeman, Karoline, additional, Gilfoyle, Elaine, additional, Goolsby, Craig A., additional, Grove, Amy, additional, Guinsburg, Ruth, additional, Hatanaka, Tetsuo, additional, Hazinski, Mary Fran, additional, Heriot, George S., additional, Hirsch, Karen G., additional, Holmberg, Mathias J., additional, Hosono, Shigeharu, additional, Hsieh, Ming-Ju, additional, Hung, Kevin K.C., additional, Hsu, Cindy H., additional, Ikeyama, Takanari, additional, Isayama, Tetsuya, additional, Kapadia, Vishal S., additional, Kawakami, Mandira Daripa, additional, Kim, Han-Suk, additional, Kloeck, David A., additional, Kudenchuk, Peter J., additional, Lagina, Anthony T., additional, Lauridsen, Kasper G., additional, Lavonas, Eric J., additional, Lockey, Andrew S., additional, Malta Hansen, Carolina, additional, Markenson, David, additional, Matsuyama, Tasuku, additional, McKinlay, Christopher J.D., additional, Mehrabian, Amin, additional, Merchant, Raina M., additional, Meyran, Daniel, additional, Morley, Peter T., additional, Morrison, Laurie J., additional, Nation, Kevin J., additional, Nemeth, Michael, additional, Neumar, Robert W., additional, Nicholson, Tonia, additional, Niermeyer, Susan, additional, Nikolaou, Nikolaos, additional, Nishiyama, Chika, additional, O’Neil, Brian J., additional, Orkin, Aaron M., additional, Osemeke, Osokogu, additional, Parr, Michael J., additional, Patocka, Catherine, additional, Pellegrino, Jeffrey L., additional, Perkins, Gavin D., additional, Perlman, Jeffrey M., additional, Rabi, Yacov, additional, Reynolds, Joshua C., additional, Ristagno, Giuseppe, additional, Roehr, Charles C., additional, Sakamoto, Tetsuya, additional, Sandroni, Claudio, additional, Sawyer, Taylor, additional, Schmölzer, Georg M., additional, Schnaubelt, Sebastian, additional, Semeraro, Federico, additional, Skrifvars, Markus B., additional, Smith, Christopher M., additional, Smyth, Michael A., additional, Soll, Roger F., additional, Sugiura, Takahiro, additional, Taylor-Phillips, Sian, additional, Trevisanuto, Daniele, additional, Vaillancourt, Christian, additional, Wang, Tzong-Luen, additional, Weiner, Gary M., additional, Welsford, Michelle, additional, Wigginton, Jane, additional, Wyllie, Jonathan P., additional, Yeung, Joyce, additional, Nolan, Jerry P., additional, Berg, Katherine M., additional, Abelairas-Gómez, Cristian, additional, Barcala-Furelos, Roberto, additional, Beerman, Stephen B., additional, Bierens, Joost, additional, Cacciola, Sofia, additional, Cellini, Jacqueline, additional, Claesson, Andreas, additional, Court, Rachael, additional, D'Arrigo, Sonia, additional, De Brier, Niels, additional, Dunne, Cody L., additional, Elsenga, Hylmar E., additional, Johnson, Samantha, additional, Kleven, Gunn, additional, Maconochie, Ian, additional, Mecrow, Tom, additional, Morgan, Patrick, additional, Otto, Quentin, additional, Palmieri, Tina L., additional, Parnia, Sam, additional, Pawar, Rahul, additional, Pereira, João, additional, Rudd, Sarah, additional, Scapigliati, Andrea, additional, Schmidt, Andrew, additional, Seesink, Jeroen, additional, Sempsrott, Justin R., additional, Szpilman, David, additional, Warner, David S., additional, Webber, Jonathon B., additional, and West, Rebecca L., additional

Published
2021
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11. 2021 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations

Author

Wyckoff, Myra H., Singletary, Eunice M., Soar, Jasmeet, Olasveengen, Theresa M., Greif, Robert, Liley, Helen G., Zideman, David, Bhanji, Farhan, Andersen, Lars W., Avis, Suzanne R., Aziz, Khalid, Bendall, Jason C., Berry, David C., Borra, Vere, B��ttiger, Bernd W., Bradley, Richard, Bray, Janet E., Breckwoldt, Jan, Carlson, Jestin N., Cassan, Pascal, Castr��n, Maaret, Chang, Wei-Tien, Charlton, Nathan P., Cheng, Adam, Chung, Sung Phil, Considine, Julie, Costa-Nobre, Daniela T., Couper, Keith, Dainty, Katie N., Davis, Peter G., de Almeida, Maria Fernanda, de Caen, Allan R., de Paiva, Edison F., Deakin, Charles D., Dj��rv, Therese, Douma, Matthew J., Drennan, Ian R., Duff, Jonathan P., Eastwood, Kathryn J., Epstein, Jonathan L., Escalante, Raffo, Fabres, Jorge G., Fawke, Joe, Finn, Judith C., Foglia, Elizabeth E., Folke, Fredrik, Freeman, Karoline, Gilfoyle, Elaine, Goolsby, Craig A., Grove, Amy, Guinsburg, Ruth, Hatanaka, Tetsuo, Hazinski, Mary Fran, Heriot, George S., Hirsch, Karen G., Holmberg, Mathias J., Hosono, Shigeharu, Hsieh, Ming-Ju, Hung, Kevin K.C., Hsu, Cindy H., Ikeyama, Takanari, Isayama, Tetsuya, Kapadia, Vishal S., Kawakami, Mandira, Kim, Han-Suk, Kloeck, David A., Kudenchuk, Peter J., Lagina, Anthony T., Lauridsen, Kasper G., Lavonas, Eric J., Lockey, Andrew S., Malta Hansen, Carolina, Markenson, David, Matsuyama, Tasuku, McKinlay, Christopher J.D., Mehrabian, Amin, Merchant, Raina M., Meyran, Daniel, Morley, Peter T., Morrison, Laurie J., Nation, Kevin J., Nemeth, Michael, Neumar, Robert W., Nicholson, Tonia, Niermeyer, Susan, Nikolaou, Nikolaos, Nishiyama, Chika, O���Neil, Brian J., Orkin, Aaron M., Osemeke, Osokogu, Parr, Michael J., Patocka, Catherine, Pellegrino, Jeffrey L., Perkins, Gavin D., Perlman, Jeffrey M., Rabi, Yacov, Reynolds, Joshua C., Ristagno, Giuseppe, Roehr, Charles C., Sakamoto, Tetsuya, Sandroni, Claudio, Sawyer, Taylor, Schm��lzer, Georg M., Schnaubelt, Sebastian, Semeraro, Federico, Skrifvars, Markus B., Smith, Christopher M., Smyth, Michael A., Soll, Roger F., Sugiura, Takahiro, Taylor-Phillips, Sian, Trevisanuto, Daniele, Vaillancourt, Christian, Wang, Tzong-Luen, Weiner, Gary M., Welsford, Michelle, Wigginton, Jane, Wyllie, Jonathan P., Yeung, Joyce, Nolan, Jerry P., Berg, Katherine M., Abelairas-G��mez, Cristian, Barcala-Furelos, Roberto, Beerman, Stephen B., Bierens, Joost, Cacciola, So���a, Cellini, Jacqueline, Claesson, Andreas, Court, Rachael, D'Arrigo, Sonia, De Brier, Niels, Dunne, Cody L., Elsenga, Hylmar E., Johnson, Samantha, Kleven, Gunn, Maconochie, Ian, Mecrow, Tom, Morgan, Patrick, Otto, Quentin, Palmieri, Tina L., Parnia, Sam, Pawar, Rahul, Pereira, Jo��o, Rudd, Sarah, Scapigliati, Andrea, Schmidt, Andrew, Seesink, Jeroen, Sempsrott, Justin R., Szpilman, David, Warner, David S., Webber, Jonathon B., and West, Rebecca L.

Subjects
610 Medicine & health
Published
2021
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12. 2021 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations: Summary From the Basic Life Support; Advanced Life Support; Neonatal Life Support; Education, Implementation, and Teams; First Aid Task Forces; and the COVID-19 Working Group

Author

Wyckoff, Myra H., Singletary, Eunice M., Soar, Jasmeet, Olasveengen, Theresa M., Greif, Robert, Liley, Helen G., Zideman, David, Bhanji, Farhan, Andersen, Lars W., Avis, Suzanne R., Aziz, Khalid, Bendall, Jason C., Berry, David C., Borra, Vere, B��ttiger, Bernd W., Bradley, Richard, Bray, Janet E., Breckwoldt, Jan, Carlson, Jestin N., Cassan, Pascal, Castr��n, Maaret, Chang, Wei-Tien, Charlton, Nathan P., Cheng, Adam, Chung, Sung Phil, Considine, Julie, Costa-Nobre, Daniela T., Couper, Keith, Dainty, Katie N., Davis, Peter G., de Almeida, Maria Fernanda, de Caen, Allan R., de Paiva, Edison F., Deakin, Charles D., Dj��rv, Therese, Douma, Matthew J., Drennan, Ian R., Duff, Jonathan P., Eastwood, Kathryn J., Epstein, Jonathan L., Escalante, Raffo, Fabres, Jorge G., Fawke, Joe, Finn, Judith C., Foglia, Elizabeth E., Folke, Fredrik, Freeman, Karoline, Gilfoyle, Elaine, Goolsby, Craig A., Grove, Amy, Guinsburg, Ruth, Hatanaka, Tetsuo, Hazinski, Mary Fran, Heriot, George S., Hirsch, Karen G., Holmberg, Mathias J., Hosono, Shigeharu, Hsieh, Ming-Ju, Hung, Kevin K.C., Hsu, Cindy H., Ikeyama, Takanari, Isayama, Tetsuya, Kapadia, Vishal S., Kawakami, Mandira, Kim, Han-Suk, Kloeck, David A., Kudenchuk, Peter J., Lagina, Anthony T., Lauridsen, Kasper G., Lavonas, Eric J., Lockey, Andrew S., Malta Hansen, Carolina, Markenson, David, Matsuyama, Tasuku, McKinlay, Christopher J.D., Mehrabian, Amin, Merchant, Raina M., Meyran, Daniel, Morley, Peter T., Morrison, Laurie J., Nation, Kevin J., Nemeth, Michael, Neumar, Robert W., Nicholson, Tonia, Niermeyer, Susan, Nikolaou, Nikolaos, Nishiyama, Chika, O���Neil, Brian J., Orkin, Aaron M., Osemeke, Osokogu, Parr, Michael J., Patocka, Catherine, Pellegrino, Jeffrey L., Perkins, Gavin D., Perlman, Jeffrey M., Rabi, Yacov, Reynolds, Joshua C., Ristagno, Giuseppe, Roehr, Charles C., Sakamoto, Tetsuya, Sandroni, Claudio, Sawyer, Taylor, Schm��lzer, Georg M., Schnaubelt, Sebastian, Semeraro, Federico, Skrifvars, Markus B., Smith, Christopher M., Smyth, Michael A., Soll, Roger F., Sugiura, Takahiro, Taylor-Phillips, Sian, Trevisanuto, Daniele, Vaillancourt, Christian, Wang, Tzong-Luen, Weiner, Gary M., Welsford, Michelle, Wigginton, Jane, Wyllie, Jonathan P., Yeung, Joyce, Nolan, Jerry P., Berg, Katherine M., Abelairas-G��mez, Cristian, Barcala-Furelos, Roberto, Beerman, Stephen B., Bierens, Joost, Cacciola, Sofia, Cellini, Jacqueline, Claesson, Andreas, Court, Rachael, D���Arrigo, Sonia, De Brier, Niels, Dunne, Cody L., Elsenga, Hylmar E., Johnson, Samantha, Kleven, Gunn, Maconochie, Ian, Mecrow, Tom, Morgan, Patrick, Otto, Quentin, Palmieri, Tina L., Parnia, Sam, Pawar, Rahul, Pereira, Jo��o, Rudd, Sarah, Scapigliati, Andrea, Schmidt, Andrew, Seesink, Jeroen, Sempsrott, Justin R., Szpilman, David, Warner, David S., Webber, Jonathon B., and West, Rebecca L

Subjects
610 Medicine & health
Published
2021
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20. 2020 International Consensus on First Aid Science With Treatment Recommendations

Author

Singletary, Eunice M., primary, Zideman, David A., additional, Bendall, Jason C., additional, Berry, David A., additional, Borra, Vere, additional, Carlson, Jestin N., additional, Cassan, Pascal, additional, Chang, Wei- Tien, additional, Charlton, Nathan P., additional, Djärv, Therese, additional, Douma, Matthew J., additional, Epstein, Jonathan L., additional, Hood, Natalie A., additional, Markenson, David S., additional, Meyran, Daniel, additional, Orkin, Aaron, additional, Sakamoto, Tetsuya, additional, Swain, Janel M., additional, Woodin, Jeff A., additional, De Buck, Emmy, additional, De Brier, Niels, additional, O, Dorien, additional, Picard, Christopher, additional, Goolsby, Craig, additional, Oliver, Emily, additional, Klaassen, Barry, additional, Poole, Kurtis, additional, Aves, Theresa, additional, Lin, Steve, additional, Handley, Anthony J., additional, Jensen, Jan, additional, Allan, Katherine S., additional, and Lee, Chien-Chang, additional

Published
2020
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23. Impact of Cereal Seed Sprouting on Its Nutritional and Technological Properties : A Critical Review

Author

Lemmens, Elien, Moroni, Alice V., Pagand, Jennifer, Heirbaut, Pieter, Ritala, Anneli, Karlen, Yann, Kim-Anne, L., van den Broeck, Hetty C., Brouns, Fred J.P.H., De Brier, Niels, Delcour, Jan A., Lemmens, Elien, Moroni, Alice V., Pagand, Jennifer, Heirbaut, Pieter, Ritala, Anneli, Karlen, Yann, Kim-Anne, L., van den Broeck, Hetty C., Brouns, Fred J.P.H., De Brier, Niels, and Delcour, Jan A.

Abstract

Sprouting induces activation and de novo synthesis of hydrolytic enzymes that make nutrients available for plant growth and development. Consumption of sprouted grains is suggested to be beneficial for human health. Positive consumer perceptions about sprouted cereals have resulted in new food and beverage product launches. However, because there is no generally accepted definition of “sprouting,” it is unclear when grains are to be called sprouted. Moreover, guidelines about how much sprouted grain material food products should contain to exert health benefits are currently lacking. Accordingly, there is no regulatory base to develop appropriate food labeling for “sprouted foods.” This review describes the nutritional and technological properties of sprouted grains in relation to processing conditions and provides guidelines to optimize sprouting practices in order to maximize nutritive value. Relatively long sprouting times (3 to 5 days) and/or high processing temperatures (25 to 35 °C) are needed to maximize the de novo synthesis and/or release of plant bioactive compounds. Nutrient compositional changes resulting from sprouting are often associated with health benefits. However, supportive data from clinical studies are very scarce, and at present it is impossible to draw any conclusion on health benefits of sprouted cereals. Finally, grains sprouted under the above-mentioned conditions are generally unfit for use in traditional food processing and it is challenging to use sprouted grains as ingredients without compromising their nutrient content. The present review provides a basis for better defining what “sprouting” is, and to help further research and development efforts in this field as well as future food regulations development.

Published
2019

24. Best Available Evidence on Communicative First Aid Interventions by Laypeople for Preventing and Relieving Posttraumatic Stress Disorder-Related Symptomatology Following Traumatic Events.

Author

De Brier, Niels, Borra, Vere, Dockx, Kim, Scheers, Hans, Stroobants, Stijn, De Buck, Emmy, Lauwers, Karen, and Vandekerckhove, Philippe

Subjects
*POST-traumatic stress, *POST-traumatic stress disorder, *FAMILY communication, *SYMPTOMS, *MENTAL health, *TREATMENT of post-traumatic stress disorder, *ADAPTABILITY (Personality), *RESEARCH, *CROSS-sectional method, *RESEARCH methodology, *MEDICAL cooperation, *EVALUATION research, *FIRST aid in illness & injury, *COMPARATIVE studies, *RESEARCH funding
Abstract

Trauma-exposed individuals are at risk of developing mental health problems, including posttraumatic stress disorder (PTSD). As an exposed individual's friend or family member may be the first person to provide posttrauma relief, informing and training laypeople in psychosocial first aid may benefit mental health outcomes of trauma-exposed individuals. We aimed to (a) collect the best available evidence on communication as a first aid intervention in assisting individuals following traumatic events and (b) formulate practical recommendations. Systematic literature searches were conducted in three databases (March 2019). Following study selection, the extracted data were tabulated and synthesized narratively. The evidence was appraised according to the GRADE methodology and evaluated by a multidisciplinary expert panel to formulate recommendations for practice. Out of 1,724 articles, no experimental studies were identified, showing a complete lack of high-quality controlled studies on the efficacy of communicative practices. However, when lower-quality study designs were included, nine cross-sectional studies constituted the best available evidence. The studies suggested that positive communication by family members, r = -.38, aOR = 0.26, β = -.22, p < .001-p < .05, and expressive coping by the victim, β = -.62, p < .001, were associated with PTSD diagnosis and/or symptom severity; however, the evidence was of very low certainty. The expert panel took the methodological limitations into account when formulating weak practical recommendations. Cross-sectional studies currently provide the best possible evidence for developing guidelines on psychosocial first aid. High-quality controlled studies are needed to establish casual associations and identify the most effective interventions. [ABSTRACT FROM AUTHOR]

Published
2021
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26. Steeping and germination of wheat (Triticum aestivum L.). II. Changes in spatial distribution and speciation of iron and zinc elements using pearling, synchrotron X-ray fluorescence microscopy mapping and X-ray absorption near-edge structure imaging

Author

Lemmens, Elien, primary, De Brier, Niels, additional, Spiers, Kathryn M., additional, Garrevoet, Jan, additional, Falkenberg, Gerald, additional, Smolders, Erik, additional, and Delcour, Jan A., additional

Published
2019
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29. Storage of an avulsed tooth prior to replantation: A systematic review and meta-analysis.

Author

De Brier, Niels, O, Dorien, Borra, Vere, Singletary, Eunice M., Zideman, David A., De Buck, Emmy, Bendall, Jason C, Berry, David C, Carlson, Jestin N, Cassan, Pascal, Chang, Wei‐Tien, Charlton, Nathan P, Djärv, Therese, Douma, Matthew, Epstein, Jonathan L, Hood, Natalie A, Markenson, David S, Meyran, Daniel, Orkin, Aaron, and Sakamoto, Tetsuya

Subjects
*TOOTH replantation, *AVULSION fractures, *META-analysis, *SYSTEMATIC reviews, *DATA extraction, *SALINE solutions, *MILK, *INFORMATION storage & retrieval systems, *MEDICAL databases, *MEDICAL information storage & retrieval systems, *TEETH injuries, *SOLUTION (Chemistry), *MEDLINE
Abstract

Background/aim: It is crucial to store an avulsed tooth appropriately to preserve the viability of the periodontal ligament cells prior to replantation. The aim of this systematic review was to identify the best available evidence for the effectiveness of any technique available to laypeople for storing an avulsed tooth compared with storage in milk or saliva.Methods: The following databases were searched (September 2019): Cochrane Library, MEDLINE, and Embase. Two reviewers independently considered trial eligibility, then extracted and analyzed data, and assessed the risk of bias. The certainty of the body of evidence was appraised according to the GRADE methodology.Results: Out of 4118 references, 33 studies were included and reported 23 comparisons of which 10 were synthesized in a meta-analysis. The limited evidence available favors storing an avulsed tooth in Hank's balanced salt solution (pooled SMD 2.47, 95% CI [1.59;3.34], P < .00001), propolis solution (pooled SMD 1.73, 95% CI [1.12;2.33], P < .00001), oral rehydration salts (pooled SMD 4.16, 95% CI [2.10;6.23], P < .0001), rice water, and cling film compared with storage in milk. The cell viability rate was significantly lower in teeth stored in saline solutions (pooled SMD -4.35, 95% CI [-7.55;-1.14], P = .008), tap water, buttermilk, castor oil, GC Tooth Mousse, and turmeric extract than those stored in milk. There is insufficient evidence to recommend for or against temporary storage of an avulsed tooth in saliva compared with alternative solutions. The certainty of evidence was considered low to very low due to limitations in study design, indirect study populations and outcome measures, and imprecision.Conclusion: Although milk was shown to extend the periodontal ligament cell viability before replantation compared with saline or tap water, the following media have also demonstrated efficacy at preserving the cell viability: Hank's balanced salt solution, propolis, oral rehydration salts, rice water, and cling film. [ABSTRACT FROM AUTHOR]

Published
2020
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33. Element distribution and iron speciation in mature wheat grains ( Triticum aestivum L.) using synchrotron X-ray fluorescence microscopy mapping and X-ray absorption near-edge structure (XANES) imaging.

Author

De Brier, Niels, Gomand, Sara V., Donner, Erica, Paterson, David, Smolders, Erik, Delcour, Jan A., and Lombi, Enzo

Subjects
*SPECIATION analysis, *COMPOSITION of wheat, *WHEAT field experiments, *X-ray fluorescence, *X-ray absorption near edge structure
Abstract

Several studies have suggested that the majority of iron (Fe) and zinc (Zn) in wheat grains are associated with phytate, but a nuanced approach to unravel important tissue-level variation in element speciation within the grain is lacking. Here, we present spatially resolved Fe-speciation data obtained directly from different grain tissues using the newly developed synchrotron-based technique of X-ray absorption near-edge spectroscopy imaging, coupling this with high-definition μ-X-ray fluorescence microscopy to map the co-localization of essential elements. In the aleurone, phosphorus (P) is co-localized with Fe and Zn, and X-ray absorption near-edge structure imaging confirmed that Fe is chelated by phytate in this tissue layer. In the crease tissues, Zn is also positively related to P distribution, albeit less so than in the aleurone. Speciation analysis suggests that Fe is bound to nicotianamine rather than phytate in the nucellar projection, and that more complex Fe structures may also be present. In the embryo, high Zn concentrations are present in the root and shoot primordium, co-occurring with sulfur and presumably bound to thiol groups. Overall, Fe is mainly concentrated in the scutellum and co-localized with P. This high resolution imaging and speciation analysis reveals the complexity of the physiological processes responsible for element accumulation and bioaccessibility. [ABSTRACT FROM AUTHOR]

Published
2016
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35. Pearling Affects the Lipid Content and Composition and Lipase Activity Levels of Wheat (Triticum aestivumL.) Roller Milling Fractions

Author

De Brier, Niels and Delcour, Jan A.

Abstract

Wheat bran contains most of the dietary fiber, vitamins, minerals, and antioxidants of the grain. Unfortunately, it readily deteriorates upon storage because it has high lipid contents and lipase activity levels, which can cause rancidity and, hence, when used in food systems, inferior product quality. We here examined the lipid composition and the lipase activities of wheat bran and the impact of pearling prior to milling thereupon. The lipid content of the outer bran layers (2.31% on a dry matter [dm] basis) is lower than that of regular bran (3.81% dm). Nevertheless, these layers have the highest concentration of free fatty acids (FFA, 0.56% dm), which is ascribed to lipid hydrolysis. Indeed, the lipase activity levels in the peripheral layers were three times higher than in the bran itself. Abrading these tissues by pearling prior to milling yielded a bran fraction with about 30% lower FFA content and 30% lower lipase activity level. Pearling offers opportunities to lower the FFA content and lipase activity levels in wheat bran and, hence, to contribute to an improved storage stability of bran.

Published
2017
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37. 1H Diffusion-Ordered Nuclear Magnetic Resonance Spectroscopic Analysis of Water-Extractable Arabinoxylan in Wheat (Triticum aestivumL.) Flour

Author

De Man, Wannes L., Vaneeckhaute, Ewoud, De Brier, Niels, Wouters, Arno G. B., Martens, Johan A., Breynaert, Eric, and Delcour, Jan A.

Abstract

The structural heterogeneity of water-extractable arabinoxylan (WE-AX) impacts wheat flour functionality. 1H diffusion-ordered (DOSY) nuclear magnetic resonance (NMR) spectroscopy revealed structural heterogeneity within WE-AX fractions obtained via graded ethanol precipitation. Combination with high-resolution 1H–1H correlation NMR spectroscopy (COSY) allowed identifying the relationship between the xylose substitution patterns and diffusion properties of the subpopulations. WE-AX fractions contained distinct subpopulations with different diffusion rates. WE-AX subpopulations with a high self-diffusivity contained high levels of monosubstituted xylose. In contrast, those with a low self-diffusivity were rich in disubstituted xylose, suggesting that disubstitution mainly occurs in WE-AX molecules with large hydrodynamic volumes. In general, WE-AX fractions precipitating at higher and lower ethanol concentrations had higher and lower self-diffusivity and more and less complex substitution patterns. Although 1H DOSY NMR, as performed in this study, was valuable for elucidating WE-AX structural heterogeneity, physical limitations arose when studying WE-AX populations with high molecular weight dispersions.

Published
2021
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38. Distribution of Minerals in Wheat Grains (Triticum aestivum L.) and in Roller Milling Fractions Affected by Pearling

Author

Sara Gomand, Erica Donner, Niels De Brier, David L. Paterson, Enzo Lombi, Jan A. Delcour, Erik Smolders, De Brier, Niels, Gomand, Sara V, Donner, Erica, Paterson, David, Delcour, Jan A, Lombi, Enzo, and Smolders, Erik

Subjects
Bran, chemistry.chemical_element, Xylem, General Chemistry, Mineral composition, pearling, μ-XRF microscopy, Nutrient, chemistry, Molybdenum, Aleurone, Botany, milling, ICP-MS, Phloem, Food science, General Agricultural and Biological Sciences
Abstract

The distribution of minerals in (pearled) wheat grains was measured by synchrotron X-ray fluorescence, and the impact of pearling (0, 3, 6, 9, and 12% by weight) on the mineral composition of flour, shorts, and bran was identified by ICP-MS. The xylem mobile elements (Mn, Si, Ca, and Sr) dominated in the outermost bran layers, while the phloem mobile elements (K, Mg, P, Fe, Zn, and Cu) were more concentrated in the aleurone. Pearling lowered the concentrations of xylem mobile elements and increased the concentrations of most phloem mobile elements in the pearled grains. Molybdenum, Cd, and especially Se were more evenly distributed, and pearling affected their concentrations in milling products less. Pearling (3%) increased the concentration of several nutrients (P, Zn, Cu) in the flour because the bran fractions reaching the flour are enriched in aleurone. The correlations of concentrations of Mg, Fe, Zn, and Cu with that of P suggested their association with phytate. Refereed/Peer-reviewed

Published
2015

39. A systematic review on oral rehydration beverages for treating exerciseassociated dehydrationPart II. The effectiveness of alternatives to carbohydrate-electrolyte drinks.

Author

De Brier N, Borra V, Berry DC, Zideman D, Singletary E, and De Buck E

Abstract

Objective: Dehydration associated with exertion is a commonly encountered condition in the first aid setting, particularly at outdoor sporting events. Part I of this back-to-back review demonstrated that commercial sports drinks can be suggested for effective restoration of fluid balance in dehydrated persons. This systematic review was undertaken to compare alternative liquids, such as milk, beer, and coconut water, with water for effective oral rehydration after prolonged exercise., Data Sources: Cochrane Library, PubMed, and Embase were searched for relevant literature in June 2022., Study Selection: Controlled experimental and observational studies involving adults and children were included when dehydration was induced by physical exercise and oral rehydration fluids were administered and compared with regular water. No additional food intake accompanied the rehydration drinks or water. Articles in all languages were included if an English abstract was available., Data Extraction: The study design, study population, intervention, outcome measures, and study limitations were extracted from each included article., Data Synthesis: Out of 3485 records, 11 studies were included comparing skim or low-fat milk, coconut water, and beer (0-5% alcohol) with water. Four studies showed that drinking skim or low-fat milk, without additional food intake, led to a statistically significant improved volume/hydration status when compared with drinking water. In three trials, no significant differences were shown at multiple timepoints for outcomes related to volume and hydration status following rehydration with fresh coconut water compared with water. Lastly, there is insufficient evidence to recommend beer for rehydration (0-5% alcohol)., Conclusions: Consuming skim or low-fat cow's milk without additional food as compared with water appears to improve volume/hydration status in persons with exercise-induced dehydration. However, evidence is of very low certainty and should be interpreted with caution.

Published
2023
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40. Oral rehydration beverages for treating exercise-associated dehydration: a systematic review.Part I: carbohydrate-electrolyte solutions.

Author

Borra V, De Brier N, Berry DC, Zideman D, Singletary E, and De Buck E

Abstract

Objective: Exercise-associated dehydration is a common problem, especially at sporting events. Although there are recommendations to drink a certain volume per kg body mass lost after exercise, there is no clear guidance about the type of rehydration beverage. The aim of this systematic review is to assess the effectiveness of carbohydrate-electrolyte solutions as a rehydration solution for exercise-associated dehydration., Data Sources: Medline (via the PubMed interface), Embase and the Cochrane Library were searched for relevant studies. The search is up to date until June 2022., Study Selection: Controlled trials involving adults and children were included if dehydration was the result of physical exercise and if drinking carbohydrate-electrolyte solutions, of any percentage carbohydrate, was compared with drinking water. All languages were included as long as an English abstract was available., Data Extraction: Data on study design, study population, interventions, outcome measures and study limitations were extracted from each included article. Certainty was assessed using GRADE., Data Synthesis: Out of 3485 screened articles, 19 studies were included that assessed carbohydrate-electrolyte solutions (0% - 9% carbohydrate) compared with water. Although there is variability amongst the identified studies, drinking 0-3.9% and, especially, 4-9% carbohydrate-electrolyte (CE) solution may be effective for rehydration., Conclusions: A potential beneficial effect of drinking CE drinks compared with water was seen for many of the reviewed outcomes. Commercial CE drinks (ideally 4-9% CE drinks or alternatively 0-3.9% CE drinks) could be suggested for rehydration in persons with exercise associated dehydration when whole foods are not available.

Published
2023
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41. 1 H Diffusion-Ordered Nuclear Magnetic Resonance Spectroscopic Analysis of Water-Extractable Arabinoxylan in Wheat ( Triticum aestivum L.) Flour.

Author

De Man WL, Vaneeckhaute E, De Brier N, Wouters AGB, Martens JA, Breynaert E, and Delcour JA

Subjects
Magnetic Resonance Spectroscopy, Water, Xylans, Flour analysis, Triticum
Abstract

The structural heterogeneity of water-extractable arabinoxylan (WE-AX) impacts wheat flour functionality. 1 H diffusion-ordered (DOSY) nuclear magnetic resonance (NMR) spectroscopy revealed structural heterogeneity within WE-AX fractions obtained via graded ethanol precipitation. Combination with high-resolution 1 H- 1 H correlation NMR spectroscopy (COSY) allowed identifying the relationship between the xylose substitution patterns and diffusion properties of the subpopulations. WE-AX fractions contained distinct subpopulations with different diffusion rates. WE-AX subpopulations with a high self-diffusivity contained high levels of monosubstituted xylose. In contrast, those with a low self-diffusivity were rich in disubstituted xylose, suggesting that disubstitution mainly occurs in WE-AX molecules with large hydrodynamic volumes. In general, WE-AX fractions precipitating at higher and lower ethanol concentrations had higher and lower self-diffusivity and more and less complex substitution patterns. Although 1 H DOSY NMR, as performed in this study, was valuable for elucidating WE-AX structural heterogeneity, physical limitations arose when studying WE-AX populations with high molecular weight dispersions.

Published
2021
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42. Impact of Cereal Seed Sprouting on Its Nutritional and Technological Properties: A Critical Review.

Author

Lemmens E, Moroni AV, Pagand J, Heirbaut P, Ritala A, Karlen Y, Lê KA, Van den Broeck HC, Brouns FJPH, De Brier N, and Delcour JA

Abstract

Sprouting induces activation and de novo synthesis of hydrolytic enzymes that make nutrients available for plant growth and development. Consumption of sprouted grains is suggested to be beneficial for human health. Positive consumer perceptions about sprouted cereals have resulted in new food and beverage product launches. However, because there is no generally accepted definition of "sprouting," it is unclear when grains are to be called sprouted. Moreover, guidelines about how much sprouted grain material food products should contain to exert health benefits are currently lacking. Accordingly, there is no regulatory base to develop appropriate food labeling for "sprouted foods." This review describes the nutritional and technological properties of sprouted grains in relation to processing conditions and provides guidelines to optimize sprouting practices in order to maximize nutritive value. Relatively long sprouting times (3 to 5 days) and/or high processing temperatures (25 to 35 °C) are needed to maximize the de novo synthesis and/or release of plant bioactive compounds. Nutrient compositional changes resulting from sprouting are often associated with health benefits. However, supportive data from clinical studies are very scarce, and at present it is impossible to draw any conclusion on health benefits of sprouted cereals. Finally, grains sprouted under the above-mentioned conditions are generally unfit for use in traditional food processing and it is challenging to use sprouted grains as ingredients without compromising their nutrient content. The present review provides a basis for better defining what "sprouting" is, and to help further research and development efforts in this field as well as future food regulations development., (© 2018 Institute of Food Technologists®.)

Published
2019
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