Search

Your search keyword '"De Backer, TLM"' showing total 10 results
Start Over Author "De Backer, TLM"
10 results on '"De Backer, TLM"'

2. May measurement month 2018: a pragmatic global screening campaign to raise awareness of blood pressure by the International Society of Hypertension (vol 40, pg 2006, 2019)

Author

Beaney, T, Burrell, LM, Castillo, RR, Charchar, FJ, Cro, S, Damasceno, A, Kruger, R, Nilsson, PM, Prabhakaran, D, Ramirez, AJ, Schlaich, MP, Schutte, AE, Tomaszewski, M, Touyz, R, Wang, JG, Weber, MA, Poulter, NR, Burazeri, G, Qirjako, G, Roshi, E, Cunashi, R, Fernandes, MJCC, Pereira, VSS, Neto, MFMP, Oliveira, PNM, Feijao, ACG, Cerniello, Y, Marin, MJ, Vasquez, GF, Espeche, WG, Stisman, D, Fuentes, IA, Zilberman, JM, Rodriguez, P, Babinyan, KY, Engibaryan, AH, Avagyan, AM, Minasyan, AA, Gevorkyan, AT, Carnagarin, R, Carrington, MJ, Sharman, JE, Lee, R, Perl, S, Niederl, E, Malik, FT, Choudhury, SR, Al Mamun, MA, Ishraquzzaman, M, Anthony, F, Connell, K, De Backer, TLM, Krzesinski, J, Houenassi, MD, Houehanou, CY, Sokolovic, S, Bahtijarevic, R, Tiro, MB, Mosepele, M, Masupe, TK, Barroso, WS, Gomes, MAM, Feitosa, ADM, Brandao, AA, Miranda, RD, Azevedo, VMAA, Dias, LM, Garcia, GDN, Martins, IPP, Dzudie, A, Kingue, S, Djomou, FAN, Njume, E, Khan, N, Lanas, FT, Garcia, MS, Paccot, MF, Torres, P, Li, Y, Liu, M, Xu, L, Li, L, Chen, X, Deng, J, Zhao, W, Fu, L, Zhou, Y, Lopez-Jaramillo, P, Otero, J, Camacho, PA, Accini, JL, Sanchez, G, Arcos, E, M'Buyamba-Kabangu, JR, Katamba, FK, Ngoyi, GN, Buila, NM, Bayauli, PM, Mbolla, EBF, Bakekolo, PR, Landa, KCM, Kaky, KGS, Kramoh, EK, Ngoran, YNK, Olsen, MH, Valoy, VL, Santillan, M, Rafael, AGM, Penaherrera, CE, Villalba, J, Ramirez, M, Arteaga, F, Delgado, P, Beistline, H, Cappuccio, FP, Keitley, J, Tay, T, Goshu, DY, Kassie, DM, Gebru, SA, Pathak, A, Denolle, T, Tsinamdzgvrishvili, B, Trapaidze, D, Sturua, L, Abesadze, T, Grdzelidze, N, Grabfelder, M, Kramer, BK, Schmeider, RE, Twumasi-Ankrah, B, Tannor, EK, Lincoln, MD, Deku, EM, Quintana, WFS, Kenerson, J, Baptiste, JED, Saintilmond, WW, Barrientos, AL, Jose, PA, More, A, Takalkar, A, Turana, Y, Widyantoro, B, Danny, SS, Djono, S, Handari, SD, Tambunan, M, Tiksnadi, BB, Hermiawaty, E, Tavassoli, E, Zolfaghari, M, Dolan, E, O'Brien, E, Borghi, C, Ferri, C, Torlasco, C, Parati, G, Nwokocha, CR, Nwokocha, M, Ogola, EN, Gitura, BM, Barasa, AL, Barasa, FA, Wairagu, AW, Nalwa, WZ, Najem, RN, Abu Alfa, AK, Fageh, HA, Msalam, OM, Derbi, HA, Bettamar, KA, Zakauskiene, U, Vickiene, A, Calmes, J, Alkerwi, A, Gantenbein, M, Ndhlovu, HLL, Masiye, JK, Chirwa, ML, Nyirenda, NM, Dhlamini, TD, Chia, YC, Ching, SM, Devaraj, NK, Ouane, N, Fane, T, Kowlessur, S, Ori, B, Heecharan, J, Alcocer, L, Chavez, A, Ruiz, G, Espinosa, C, Gomez-Alvarez, E, Neupane, D, Bhattarai, H, Ranabhat, K, Adhikari, TB, Koirala, S, Toure, IA, Soumana, KH, Wahab, KW, Omotoso, AB, Sani, MU, Okubadejo, NU, Nadar, SK, Al-Riyami, HA, Ishaq, M, Memon, F, Sidique, S, Choudhry, HA, Khan, RA, Ayala, M, Maidana, AJO, Bogado, GG, Ona, D, Atilano, A, Granada, C, Bartolome, R, Manese, L, Mina, A, Dumlao, MC, Villaruel, MC, Gomez, L, Jozwiak, J, Malyszko, J, Banach, M, Mastej, M, Rodrigues, DCMM, Martins, LL, Paval, A, Dorobantu, M, Konradi, AO, Chazova, IE, Rotar, O, Spoares, MC, Viegas, D, Almustafa, BA, Alshurafa, SA, Brady, A, Bovet, P, Viswanathan, B, Oladapo, OO, Russell, JW, Beheiry, HM, Ali, IA, Osman, AAA, Fahal, NAW, Osman, HA, Altahir, F, Persson, M, Wuerzner, G, Burkard, T, Wang, TD, Lin, HJ, Pan, HY, Chen, WJ, Lin, E, Mondo, CK, Ingabire, PM, Khomazyuk, TT, Krotova, VV, Negresku, E, Evstigneeva, O, Bazargani, NN, Agrawal, A, Bin Belaila, BA, Suhail, AM, Muhammed, KO, Shuri, HH, Wainford, RD, Levy, PD, Boggia, JJ, Garre, LL, Hernandez-Hernandez, R, Octavio-Seijas, JA, Lopez-Rivera, JA, Morr, I, Duin, A, Huynh, M, Cao, ST, Nguyen, VL, To, M, Phan, HN, Cockroft, J, McDonnell, B, Goma, FM, Syatalimi, C, Chifamba, J, Gwini, R, Tiburcio, O, and Xia, X

Subjects
Science & Technology, Cardiac & Cardiovascular Systems, Cardiovascular System & Hematology, Cardiovascular System & Cardiology, 1103 Clinical Sciences, Life Sciences & Biomedicine, 1102 Cardiorespiratory Medicine and Haematology
Published
2019

3. May Measurement Month 2018: a pragmatic global screening campaign to raise awareness of blood pressure by the International Society of Hypertension

Author

Beaney, T, Burrell, LM, Castillo, RR, Charchar, FJ, Cro, S, Damasceno, A, Kruger, R, Nilsson, PM, Prabhakaran, D, Ramirez, AJ, Schlaich, MP, Schutte, AE, Tomaszewski, M, Touyz, R, Wang, J-G, Weber, MA, Poulter, NR, Burazeri, G, Qirjako, G, Roshi, E, Cunashi, R, Fernandes, MJCC, Pereira, SSV, Neto, MFMP, Oliveira, PNM, Feijao, ACG, Cerniello, Y, Marin, MJ, Vasquez, FG, Espeche, WG, Stisman, D, Fuentes, IA, Zilberman, JM, Rodriguez, P, Babinyan, KY, Engibaryan, AH, Avagyan, AM, Minasyan, AA, Gevorkyan, AT, Carnagarin, R, Carrington, MJ, Sharman, JE, Lee, R, Perl, S, Niederl, E, Malik, F-T-N, Choudhury, SR, Al Mamun, MA, Ishraquzzaman, M, Anthony, F, Connell, K, De Backer, TLM, Krzesinski, J, Houenassi, MD, Houehanou, CY, Sokolovic, S, Bahtijarevic, R, Tiro, MB, Mosepele, M, Masupe, TK, Barroso, WS, Gomes, MAM, Feitosa, ADM, Brandao, AA, Miranda, RD, Azevedo, VMAA, Dias, LM, Garcia, GDN, Martins, IPP, Dzudie, A, Kingue, S, Djomou, FAN, Njume, E, Khan, N, Lanas, FT, Garcia, MS, Paccot, MF, Torres, PI, Li, Y, Liu, M, Xu, L, Li, L, Chen, X, Deng, J, Zhao, W, Fu, L, Zhou, Y, Lopez-Jaramillo, P, Otero, J, Camacho, PA, Accini, JL, Sanchez, G, Arcos, E, Buyamba-Kabangu, J-RM, Katamba, FK, Ngoyi, GN, Buila, NM, Bayauli, PM, Mbolla, BFE, Bakekolo, PR, Landa, CMK, Kaky, GSK, Kramoh, EK, Ngoran, YNK, Olsen, MH, Valoy, LV, Santillan, M, Medina, ARG, Penaherrera, CE, Villalba, J, Ramirez, MI, Arteaga, F, Delgado, P, Beistline, H, Cappuccio, FP, Keitley, J, Tay, T, Goshu, DY, Kassie, DM, Gebru, SA, Pathak, A, Denolle, T, Tsinamdzgvrishvili, B, Trapaidze, D, Sturua, L, Abesadze, T, Grdzelidze, N, Grabfelder, M, Kramer, BK, Schmeider, RE, Twumasi-Ankrah, B, Tannor, EK, Lincoln, MD, Deku, EM, Quintana, FSW, Kenerson, J, Baptiste, EDJ, Saintilmond, WW, Barrientos, AL, Peiger, B, Lagos, AR, Forgas, MA, Lee, VWY, Tomlinson, BWY, Jarai, Z, Pall, D, More, A, Maheshwari, A, Verma, N, Sharma, M, Mukherjee, TK, Patil, M, Jose, AP, Takalkar, A, Turana, Y, Widyantoro, B, Danny, SS, Djono, S, Handari, SD, Tambunan, M, Tiksnadi, BB, Hermiawaty, E, Tavassoli, E, Zolfaghari, M, Dolan, E, O'Brien, E, Borghi, C, Ferri, C, Torlasco, C, Parati, G, Nwokocha, CR, Nwokocha, MI, Ogola, EN, Gitura, BM, Barasa, AL, Barasa, FA, Wairagu, AW, Nalwa, WZ, Najem, RN, Abu Alfa, AK, Fageh, HA, Msalam, OM, Derbi, HA, Bettamar, KA, Zakauskiene, U, Vickiene, A, Calmes, J, Alkerwi, A, Gantenbein, M, Ndhlovu, HLL, Masiye, JK, Chirwa, ML, Nyirenda, NM, Dhlamini, TD, Chia, YC, Ching, SM, Devaraj, NK, Ouane, N, Fane, T, Kowlessur, S, Ori, B, Heecharan, J, Alcocer, L, Chavez, A, Ruiz, G, Espinosa, C, Gomez-Alvarez, E, Neupane, D, Bhattarai, H, Ranabhat, K, Adhikari, TB, Koirala, S, Toure, IA, Soumana, KH, Wahab, K, Omotoso, AB, Sani, MU, Okubadejo, NU, Nadar, SK, Al-Riyami, HA, Ishaq, M, Memon, F, Sidique, S, Choudhry, HA, Khan, RA, Ayala, M, Maidana, AJO, Bogado, GGG, Ona, DI, Atilano, A, Granada, C, Bartolome, R, Manese, L, Mina, A, Dumlao, MC, Villaruel, MC, Gomez, L, Jozwiak, J, Malyszko, J, Banach, M, Mastej, M, Rodrigues, MMDC, Martins, LL, Paval, A, Dorobantu, M, Konradi, AO, Chazova, IE, Rotar, O, Spoares, MC, Viegas, D, Almustafa, BA, Alshurafa, SA, Brady, A, Bovet, P, Viswanathan, B, Oladapo, OO, Russell, JW, Brguljan-Hitij, J, Bozic, N, Knez, J, Dolenc, P, Hassan, MM, Woodiwiss, AJ, Myburgh, C, Vally, M, Ruilope, LM, Molinero, A, Rodilla, E, Gijon-Conde, T, Beheiry, HM, Ali, IA, Osman, AAA, Fahal, NAW, Osman, HA, Altahir, F, Persson, M, Wuerzner, G, Burkard, T, Wang, T-D, Lin, H-J, Pan, H-Y, Chen, W-J, Lin, E, Mondo, CK, Ingabire, PM, Khomazyuk, TTA, Krotova, VV-Y, Negresku, E, Evstigneeva, O, Bazargani, NNB, Agrawal, A, Bin Belaila, BA, Suhail, AM, Muhammed, KO, Shuri, HH, Wainford, RD, Levy, PD, Boggia, JJG, Garre, LL, Hernandez-Hernandez, R, Octavio-Seijas, JA, Lopez-Rivera, JA, Morr, I, Duin, A, Huynh, MV, Cao, ST, Nguyen, VL, To, M, Phan, HN, Cockroft, J, McDonnell, B, Goma, FM, Syatalimi, C, Chifamba, J, Gwini, R, Xia, X, Tiburcio, OV, Beaney, T, Burrell, LM, Castillo, RR, Charchar, FJ, Cro, S, Damasceno, A, Kruger, R, Nilsson, PM, Prabhakaran, D, Ramirez, AJ, Schlaich, MP, Schutte, AE, Tomaszewski, M, Touyz, R, Wang, J-G, Weber, MA, Poulter, NR, Burazeri, G, Qirjako, G, Roshi, E, Cunashi, R, Fernandes, MJCC, Pereira, SSV, Neto, MFMP, Oliveira, PNM, Feijao, ACG, Cerniello, Y, Marin, MJ, Vasquez, FG, Espeche, WG, Stisman, D, Fuentes, IA, Zilberman, JM, Rodriguez, P, Babinyan, KY, Engibaryan, AH, Avagyan, AM, Minasyan, AA, Gevorkyan, AT, Carnagarin, R, Carrington, MJ, Sharman, JE, Lee, R, Perl, S, Niederl, E, Malik, F-T-N, Choudhury, SR, Al Mamun, MA, Ishraquzzaman, M, Anthony, F, Connell, K, De Backer, TLM, Krzesinski, J, Houenassi, MD, Houehanou, CY, Sokolovic, S, Bahtijarevic, R, Tiro, MB, Mosepele, M, Masupe, TK, Barroso, WS, Gomes, MAM, Feitosa, ADM, Brandao, AA, Miranda, RD, Azevedo, VMAA, Dias, LM, Garcia, GDN, Martins, IPP, Dzudie, A, Kingue, S, Djomou, FAN, Njume, E, Khan, N, Lanas, FT, Garcia, MS, Paccot, MF, Torres, PI, Li, Y, Liu, M, Xu, L, Li, L, Chen, X, Deng, J, Zhao, W, Fu, L, Zhou, Y, Lopez-Jaramillo, P, Otero, J, Camacho, PA, Accini, JL, Sanchez, G, Arcos, E, Buyamba-Kabangu, J-RM, Katamba, FK, Ngoyi, GN, Buila, NM, Bayauli, PM, Mbolla, BFE, Bakekolo, PR, Landa, CMK, Kaky, GSK, Kramoh, EK, Ngoran, YNK, Olsen, MH, Valoy, LV, Santillan, M, Medina, ARG, Penaherrera, CE, Villalba, J, Ramirez, MI, Arteaga, F, Delgado, P, Beistline, H, Cappuccio, FP, Keitley, J, Tay, T, Goshu, DY, Kassie, DM, Gebru, SA, Pathak, A, Denolle, T, Tsinamdzgvrishvili, B, Trapaidze, D, Sturua, L, Abesadze, T, Grdzelidze, N, Grabfelder, M, Kramer, BK, Schmeider, RE, Twumasi-Ankrah, B, Tannor, EK, Lincoln, MD, Deku, EM, Quintana, FSW, Kenerson, J, Baptiste, EDJ, Saintilmond, WW, Barrientos, AL, Peiger, B, Lagos, AR, Forgas, MA, Lee, VWY, Tomlinson, BWY, Jarai, Z, Pall, D, More, A, Maheshwari, A, Verma, N, Sharma, M, Mukherjee, TK, Patil, M, Jose, AP, Takalkar, A, Turana, Y, Widyantoro, B, Danny, SS, Djono, S, Handari, SD, Tambunan, M, Tiksnadi, BB, Hermiawaty, E, Tavassoli, E, Zolfaghari, M, Dolan, E, O'Brien, E, Borghi, C, Ferri, C, Torlasco, C, Parati, G, Nwokocha, CR, Nwokocha, MI, Ogola, EN, Gitura, BM, Barasa, AL, Barasa, FA, Wairagu, AW, Nalwa, WZ, Najem, RN, Abu Alfa, AK, Fageh, HA, Msalam, OM, Derbi, HA, Bettamar, KA, Zakauskiene, U, Vickiene, A, Calmes, J, Alkerwi, A, Gantenbein, M, Ndhlovu, HLL, Masiye, JK, Chirwa, ML, Nyirenda, NM, Dhlamini, TD, Chia, YC, Ching, SM, Devaraj, NK, Ouane, N, Fane, T, Kowlessur, S, Ori, B, Heecharan, J, Alcocer, L, Chavez, A, Ruiz, G, Espinosa, C, Gomez-Alvarez, E, Neupane, D, Bhattarai, H, Ranabhat, K, Adhikari, TB, Koirala, S, Toure, IA, Soumana, KH, Wahab, K, Omotoso, AB, Sani, MU, Okubadejo, NU, Nadar, SK, Al-Riyami, HA, Ishaq, M, Memon, F, Sidique, S, Choudhry, HA, Khan, RA, Ayala, M, Maidana, AJO, Bogado, GGG, Ona, DI, Atilano, A, Granada, C, Bartolome, R, Manese, L, Mina, A, Dumlao, MC, Villaruel, MC, Gomez, L, Jozwiak, J, Malyszko, J, Banach, M, Mastej, M, Rodrigues, MMDC, Martins, LL, Paval, A, Dorobantu, M, Konradi, AO, Chazova, IE, Rotar, O, Spoares, MC, Viegas, D, Almustafa, BA, Alshurafa, SA, Brady, A, Bovet, P, Viswanathan, B, Oladapo, OO, Russell, JW, Brguljan-Hitij, J, Bozic, N, Knez, J, Dolenc, P, Hassan, MM, Woodiwiss, AJ, Myburgh, C, Vally, M, Ruilope, LM, Molinero, A, Rodilla, E, Gijon-Conde, T, Beheiry, HM, Ali, IA, Osman, AAA, Fahal, NAW, Osman, HA, Altahir, F, Persson, M, Wuerzner, G, Burkard, T, Wang, T-D, Lin, H-J, Pan, H-Y, Chen, W-J, Lin, E, Mondo, CK, Ingabire, PM, Khomazyuk, TTA, Krotova, VV-Y, Negresku, E, Evstigneeva, O, Bazargani, NNB, Agrawal, A, Bin Belaila, BA, Suhail, AM, Muhammed, KO, Shuri, HH, Wainford, RD, Levy, PD, Boggia, JJG, Garre, LL, Hernandez-Hernandez, R, Octavio-Seijas, JA, Lopez-Rivera, JA, Morr, I, Duin, A, Huynh, MV, Cao, ST, Nguyen, VL, To, M, Phan, HN, Cockroft, J, McDonnell, B, Goma, FM, Syatalimi, C, Chifamba, J, Gwini, R, Xia, X, and Tiburcio, OV

Abstract

AIMS: Raised blood pressure (BP) is the biggest contributor to mortality and disease burden worldwide and fewer than half of those with hypertension are aware of it. May Measurement Month (MMM) is a global campaign set up in 2017, to raise awareness of high BP and as a pragmatic solution to a lack of formal screening worldwide. The 2018 campaign was expanded, aiming to include more participants and countries. METHODS AND RESULTS: Eighty-nine countries participated in MMM 2018. Volunteers (≥18 years) were recruited through opportunistic sampling at a variety of screening sites. Each participant had three BP measurements and completed a questionnaire on demographic, lifestyle, and environmental factors. Hypertension was defined as a systolic BP ≥140 mmHg or diastolic BP ≥90 mmHg, or taking antihypertensive medication. In total, 74.9% of screenees provided three BP readings. Multiple imputation using chained equations was used to impute missing readings. 1 504 963 individuals (mean age 45.3 years; 52.4% female) were screened. After multiple imputation, 502 079 (33.4%) individuals had hypertension, of whom 59.5% were aware of their diagnosis and 55.3% were taking antihypertensive medication. Of those on medication, 60.0% were controlled and of all hypertensives, 33.2% were controlled. We detected 224 285 individuals with untreated hypertension and 111 214 individuals with inadequately treated (systolic BP ≥ 140 mmHg or diastolic BP ≥ 90 mmHg) hypertension. CONCLUSION: May Measurement Month expanded significantly compared with 2017, including more participants in more countries. The campaign identified over 335 000 adults with untreated or inadequately treated hypertension. In the absence of systematic screening programmes, MMM was effective at raising awareness at least among these individuals at risk.

Published
2019

6. Community pharmacy-based study of adherence to non-vitamin K antagonist oral anticoagulants.

Author

Capiau A, Mehuys E, Van Tongelen I, Christiaens T, De Sutter A, Steurbaut S, Moudallel S, Rydant S, Vrijens B, de Backer TLM, and Boussery K

Subjects
Administration, Oral, Aged, Atrial Fibrillation complications, Cross-Sectional Studies, Female, Humans, Male, Retrospective Studies, Risk Factors, Thromboembolism etiology, Anticoagulants administration & dosage, Atrial Fibrillation drug therapy, Medication Adherence statistics & numerical data, Pharmacies statistics & numerical data, Thromboembolism prevention & control
Abstract

Objective: This study aimed to assess implementation adherence (how well the patient's actual intake matches the prescribed dosing regimen) to non-vitamin K antagonist oral anticoagulants (NOACs) and to explore experiences with and beliefs about NOACs in a real-world sample of long-term NOAC users., Methods: A cross-sectional observational study was conducted in home-dwelling adults who started taking a NOAC at least 1 year prior to inclusion. Pharmacy dispensing data were used to calculate the Medication Possession Ratio (MPR). Patients were recruited in 158 community pharmacies in Flanders, Belgium. They completed a questionnaire collecting basic characteristics and exploring self-reported adherence to NOACs (using the Medication Adherence Report Scale, MARS) and experiences with and beliefs about NOACs (using the Beliefs about Medicines Questionnaire, BMQ)., Results: A total of 766 patients (mean age 76.2±8.8 years, median CHA 2 DS 2 -VASc score 4 (IQR=3-4)) were included. The majority (93.5%) used NOAC for stroke prevention in atrial fibrillation. The median MPR was 95.2% (IQR=87.8-99.7) which corresponds with half of the study population not taking their NOAC on at least 17 cumulative days per year. Almost 21% of participants reported non-adherence on the MARS (score <25), with unintentional non-adherence (forgetfulness) most frequently reported (15.4%). Although two-thirds of NOAC users indicated to experience adverse drug reactions, the BMQ demonstrated a positive attitude towards NOAC therapy, where necessity beliefs outweigh the concerns., Conclusions: Our data indicate that long-term NOAC users have high implementation adherence and a positive attitude towards NOAC therapy. However, taking into account patients' thromboembolic risk and NOACs' short half-lives, further optimisation of NOAC use seems warranted in this population., Competing Interests: Competing interests: BV reports that he is the scientific lead at AARDEX Group., (© Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.)

Published
2020
Full Text
View/download PDF

7. Average pixel intensity method for prediction of outcome in secondary mitral regurgitation.

Author

Kamoen V, De Buyzere M, El Haddad M, de Backer TLM, and Timmermans F

Subjects
Aged, Aged, 80 and over, Disease Progression, Female, Hemodynamics, Humans, Male, Middle Aged, Mitral Valve physiopathology, Mitral Valve Insufficiency mortality, Mitral Valve Insufficiency physiopathology, Mitral Valve Insufficiency therapy, Predictive Value of Tests, Prognosis, Prospective Studies, Risk Assessment, Risk Factors, Severity of Illness Index, Echocardiography, Doppler, Mitral Valve diagnostic imaging, Mitral Valve Insufficiency diagnostic imaging
Abstract

Background: Echocardiographic grading of secondary mitral regurgitation (SMR) severity is challenging and involves multiple guideline-recommended parameters. We previously introduced the average pixel intensity (API) method for grading SMR. In this study, the clinical outcome in SMR based on the API method for grading MR was compared with conventional grading methods., Methods: 231 patients with systolic heart failure and reduced ejection fraction (ischaemic/non-ischaemic) and SMR were prospectively enrolled. MR was graded using all guideline-recommended parameters and the API method, which is based on the pixel intensity of the continuous wave Doppler signal. The primary outcome was MACE (major adverse cardiac event)., Results: The API method was applicable in 98% of patients with SMR (n=227). During a median follow-up of 24 months, 98 patients (43%) had a MACE (cardiovascular mortality (n=50, 22%), heart failure hospitalisation (n=44, 19%), mitral valve surgery (n=11, 5%), percutaneous mitral intervention (n=12, 5%), heart transplantation (n=5, 2%)). On log-rank test, the API method was highly significant in predicting clinical outcome. On multivariable Cox proportional hazard analysis, SMR grading with the API method was an independent predictor of clinical outcome (along with NYHA class and right ventricular systolic pressure; p<0.001), increasing the event risk by 9% per 10 au API rise (p=0.001). In the same multivariable analysis, proximal isovelocity surface area (PISA)-effective regurgitant orifice area or PISA-regurgitant volume were not independent predictors of events (p=0.18 and 0.26, respectively)., Conclusion: SMR grading with the API method is an independent predictor of clinical outcome and provides prognostic information in addition to clinical and other echocardiographic variables., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.)

Published
2020
Full Text
View/download PDF

10. Vascular dysregulation in normal-tension glaucoma is not affected by structure and function of the microcirculation or macrocirculation at rest: a case-control study.

Author

Bossuyt J, Vandekerckhove G, De Backer TLM, Van de Velde S, Azermai M, Stevens AM, Kestelyn P, Raemdonck T, Segers P, Vanmolkot F, and Van Bortel LM

Subjects
Aged, Carotid Intima-Media Thickness, Case-Control Studies, Female, Heart Function Tests methods, Humans, Intraocular Pressure physiology, Male, Netherlands, Optic Nerve Diseases etiology, Optic Nerve Diseases physiopathology, Pulse Wave Analysis methods, Research Design, Statistics as Topic, Tonometry, Ocular methods, Vascular Stiffness physiology, Glaucoma complications, Glaucoma diagnosis, Glaucoma physiopathology, Hemodynamics, Microcirculation, Optic Nerve blood supply, Optic Nerve Diseases prevention & control, Regional Blood Flow
Abstract

In normal-tension glaucoma (NTG), optic nerve damage occurs despite a normal intraocular pressure. Studies implicating systemic blood pressure or, more recently, arterial stiffness in the pathophysiology of NTG have produced conflicting results. Our aim was to investigate whether NTG is associated with alterations in the macrocirculation or microcirculation, cardiac function, and peripheral and central hemodynamics. Thirty patients with NTG (mean age 65 years, range 46-79) and 33 healthy subjects (mean age 67 years, range 42-79) matched for age and sex were included in the study. Exclusion criteria (for both cases and controls) were history of cardiovascular disease, diabetes mellitus, severe hypertension, and hypercholesterolemia. Aortic stiffness was measured using carotid-femoral pulse wave velocity (PWV), central hemodynamics using carotid artery applanation tonometry, and diameter, stiffness, and intima-media thickness (IMT) of the carotid and femoral artery using echo-tracking. Total peripheral resistance index (TPRI) was derived from mean arterial pressure and cardiac index, measured using ultrasound. There were no statistically significant differences in arterial structure nor function between NTG patients and age and sex-matched controls. NTG versus controls, respectively: brachial blood pressure 126 ± 15/77 ± 8 versus 127 ± 16/76 ± 7 mm Hg, P = 0.81; carotid-femoral PWV 9.8 ± 2.1 versus 10.1 ± 1.9 m/s, P = 0.60; TPRI 1833 ± 609 versus 1779 ± 602 dyne.s/cm5/m2, P = 0.79; and carotid IMT 0.65 ± 0.14 versus 0.68 ± 0.13 mm, P = 0.39. This study could not show an association of NTG with altered IMT, arterial stiffness, total peripheral resistance, cardiac output, and peripheral or central hemodynamics at rest. Although the majority of these NTG patients do exhibit symptoms of vascular dysregulation, in the present study this was not translated into alterations in the microcirculation or macrocirculation at rest.

Published
2015
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results