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1. Gastrointestinal stromal tumours: ESMO–EURACAN–GENTURIS Clinical Practice Guidelines for diagnosis, treatment and follow-up

Author

Casali, P.G., Blay, J.Y., Abecassis, N., Bajpai, J., Bauer, S., Biagini, R., Bielack, S., Bonvalot, S., Boukovinas, I., Bovee, J.V.M.G., Boye, K., Brodowicz, T., Buonadonna, A., De Álava, E., Dei Tos, A.P., Del Muro, X.G., Dufresne, A., Eriksson, M., Fedenko, A., Ferraresi, V., Ferrari, A., Frezza, A.M., Gasperoni, S., Gelderblom, H., Gouin, F., Grignani, G., Haas, R., Hassan, A.B., Hindi, N., Hohenberger, P., Joensuu, H., Jones, R.L., Jungels, C., Jutte, P., Kasper, B., Kawai, A., Kopeckova, K., Krákorová, D.A., Le Cesne, A., Le Grange, F., Legius, E., Leithner, A., Lopez-Pousa, A., Martin-Broto, J., Merimsky, O., Messiou, C., Miah, A.B., Mir, O., Montemurro, M., Morosi, C., Palmerini, E., Pantaleo, M.A., Piana, R., Piperno-Neumann, S., Reichardt, P., Rutkowski, P., Safwat, A.A., Sangalli, C., Sbaraglia, M., Scheipl, S., Schöffski, P., Sleijfer, S., Strauss, D., Strauss, S.J., Hall, K Sundby, Trama, A., Unk, M., van de Sande, M.A.J., van der Graaf, W.T.A., van Houdt, W.J., Frebourg, T., Gronchi, A., and Stacchiotti, S.

Published
2022
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2. Bone sarcomas: ESMO–EURACAN–GENTURIS–ERN PaedCan Clinical Practice Guideline for diagnosis, treatment and follow-up

Author

Strauss, S.J., Frezza, A.M., Abecassis, N., Bajpai, J., Bauer, S., Biagini, R., Bielack, S., Blay, J.Y., Bolle, S., Bonvalot, S., Boukovinas, I., Bovee, J.V.M.G., Boye, K., Brennan, B., Brodowicz, T., Buonadonna, A., de Álava, E., Dei Tos, A.P., Garcia del Muro, X., Dufresne, A., Eriksson, M., Fagioli, F., Fedenko, A., Ferraresi, V., Ferrari, A., Gaspar, N., Gasperoni, S., Gelderblom, H., Gouin, F., Grignani, G., Gronchi, A., Haas, R., Hassan, A.B., Hecker-Nolting, S., Hindi, N., Hohenberger, P., Joensuu, H., Jones, R.L., Jungels, C., Jutte, P., Kager, L., Kasper, B., Kawai, A., Kopeckova, K., Krákorová, D.A., Le Cesne, A., Le Grange, F., Legius, E., Leithner, A., López Pousa, A., Martin-Broto, J., Merimsky, O., Messiou, C., Miah, A.B., Mir, O., Montemurro, M., Morland, B., Morosi, C., Palmerini, E., Pantaleo, M.A., Piana, R., Piperno-Neumann, S., Reichardt, P., Rutkowski, P., Safwat, A.A., Sangalli, C., Sbaraglia, M., Scheipl, S., Schöffski, P., Sleijfer, S., Strauss, D., Sundby Hall, K., Trama, A., Unk, M., van de Sande, M.A.J., van der Graaf, W.T.A., van Houdt, W.J., Frebourg, T., Ladenstein, R., Casali, P.G., and Stacchiotti, S.

Published
2021
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3. Soft tissue and visceral sarcomas: ESMO–EURACAN–GENTURIS Clinical Practice Guidelines for diagnosis, treatment and follow-up☆

Author

Gronchi, A., Miah, A.B., Dei Tos, A.P., Abecassis, N., Bajpai, J., Bauer, S., Biagini, R., Bielack, S., Blay, J.Y., Bolle, S., Bonvalot, S., Boukovinas, I., Bovee, J.V.M.G., Boye, K., Brennan, B., Brodowicz, T., Buonadonna, A., De Álava, E., Del Muro, X.G., Dufresne, A., Eriksson, M., Fagioli, F., Fedenko, A., Ferraresi, V., Ferrari, A., Frezza, A.M., Gasperoni, S., Gelderblom, H., Gouin, F., Grignani, G., Haas, R., Hassan, A.B., Hecker-Nolting, S., Hindi, N., Hohenberger, P., Joensuu, H., Jones, R.L., Jungels, C., Jutte, P., Kager, L., Kasper, B., Kawai, A., Kopeckova, K., Krákorová, D.A., Le Cesne, A., Le Grange, F., Legius, E., Leithner, A., Lopez-Pousa, A., Martin-Broto, J., Merimsky, O., Messiou, C., Mir, O., Montemurro, M., Morland, B., Morosi, C., Palmerini, E., Pantaleo, M.A., Piana, R., Piperno-Neumann, S., Reichardt, P., Rutkowski, P., Safwat, A.A., Sangalli, C., Sbaraglia, M., Scheipl, S., Schöffski, P., Sleijfer, S., Strauss, D., Strauss, S., Sundby Hall, K., Trama, A., Unk, M., van de Sande, M.A.J., van der Graaf, W.T.A., van Houdt, W.J., Frebourg, T., Casali, P.G., and Stacchiotti, S.

Published
2021
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4. Epithelioid hemangioendothelioma, an ultra-rare cancer: a consensus paper from the community of experts

Author

Stacchiotti, S., Miah, A.B., Frezza, A.M., Messiou, C., Morosi, C., Caraceni, A., Antonescu, C.R., Bajpai, J., Baldini, E., Bauer, S., Biagini, R., Bielack, S., Blay, J.Y., Bonvalot, S., Boukovinas, I., Bovee, J.V.M.G., Boye, K., Brodowicz, T., Callegaro, D., De Alava, E., Deoras-Sutliff, M., Dufresne, A., Eriksson, M., Errani, C., Fedenko, A., Ferraresi, V., Ferrari, A., Fletcher, C.D.M., Garcia del Muro, X., Gelderblom, H., Gladdy, R.A., Gouin, F., Grignani, G., Gutkovich, J., Haas, R., Hindi, N., Hohenberger, P., Huang, P., Joensuu, H., Jones, R.L., Jungels, C., Kasper, B., Kawai, A., Le Cesne, A., Le Grange, F., Leithner, A., Leonard, H., Lopez Pousa, A., Martin Broto, J., Merimsky, O., Merriam, P., Miceli, R., Mir, O., Molinari, M., Montemurro, M., Oldani, G., Palmerini, E., Pantaleo, M.A., Patel, S., Piperno-Neumann, S., Raut, C.P., Ravi, V., Razak, A.R.A., Reichardt, P., Rubin, B.P., Rutkowski, P., Safwat, A.A., Sangalli, C., Sapisochin, G., Sbaraglia, M., Scheipl, S., Schöffski, P., Strauss, D., Strauss, S.J., Sundby Hall, K., Tap, W.D., Trama, A., Tweddle, A., van der Graaf, W.T.A., Van De Sande, M.A.J., Van Houdt, W., van Oortmerssen, G., Wagner, A.J., Wartenberg, M., Wood, J., Zaffaroni, N., Zimmermann, C., Casali, P.G., Dei Tos, A.P., and Gronchi, A.

Published
2021
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5. Selective modulation by PARP-1 of HIF-1α-recruitment to chromatin during hypoxia is required for tumor adaptation to hypoxic conditions

Author

Martí, Juan Manuel, Garcia-Diaz, Angel, Delgado-Bellido, Daniel, O'Valle, Francisco, González-Flores, Ariannys, Carlevaris, Onintza, Rodríguez-Vargas, José Manuel, Amé, Jean Christophe, Dantzer, Françoise, King, George L., Dziedzic, Klaudia, Berra, Edurne, de Álava, E., Amaral, A.T., Hammond, Ester M., and Oliver, F. Javier

Published
2021
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6. Soft tissue and visceral sarcomas: ESMO–EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up

Author

Casali, P.G., Abecassis, N., Bauer, S., Biagini, R., Bielack, S., Bonvalot, S., Boukovinas, I., Bovee, J V M G, Brodowicz, T., Broto, J.M., Buonadonna, A., De Álava, E., Dei Tos, A.P., Del Muro, X.G., Dileo, P., Eriksson, M., Fedenko, A., Ferraresi, V., Ferrari, A., Ferrari, S., Frezza, A.M., Gasperoni, S., Gelderblom, H., Gil, T., Grignani, G., Gronchi, A., Haas, R.L., Hannu, A., Hassan, B., Hohenberger, P., Issels, R., Joensuu, H., Jones, R.L., Judson, I., Jutte, P., Kaal, S., Kasper, B., Kopeckova, K., Krákorová, D.A., Le Cesne, A., Lugowska, I., Merimsky, O., Montemurro, M., Pantaleo, M.A., Piana, R., Picci, P., Piperno-Neumann, S., Pousa, A.L., Reichardt, P., Robinson, M.H., Rutkowski, P., Safwat, A.A., Schöffski, P., Sleijfer, S., Stacchiotti, S., Sundby Hall, K., Unk, M., Van Coevorden, F., Van der Graaf, W., Whelan, J., Wardelmann, E., Zaikova, O., and Blay, J.Y.

Published
2018
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7. Bone sarcomas: ESMO–PaedCan–EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up

Author

Casali, P.G., Bielack, S., Abecassis, N., Aro, H.T., Bauer, S., Biagini, R., Bonvalot, S., Boukovinas, I., Bovee, J V M G, Brennan, B., Brodowicz, T., Broto, J.M., Brugières, L., Buonadonna, A., De Álava, E., Dei Tos, A.P., Del Muro, X.G., Dileo, P., Dhooge, C., Eriksson, M., Fagioli, F., Fedenko, A., Ferraresi, V., Ferrari, A., Ferrari, S., Frezza, A.M., Gaspar, N., Gasperoni, S., Gelderblom, H., Gil, T., Grignani, G., Gronchi, A., Haas, R.L., Hassan, B., Hecker-Nolting, S., Hohenberger, P., Issels, R., Joensuu, H., Jones, R.L., Judson, I., Jutte, P., Kaal, S., Kager, L., Kasper, B., Kopeckova, K., Krákorová, D.A., Ladenstein, R., Le Cesne, A., Lugowska, I., Merimsky, O., Montemurro, M., Morland, B., Pantaleo, M.A., Piana, R., Picci, P., Piperno-Neumann, S., Pousa, A.L., Reichardt, P., Robinson, M.H., Rutkowski, P., Safwat, A.A., Schöffski, P., Sleijfer, S., Stacchiotti, S., Strauss, S.J., Sundby Hall, K., Unk, M., Van Coevorden, F., van der Graaf, W.T.A., Whelan, J., Wardelmann, E., Zaikova, O., and Blay, J.Y.

Published
2018
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8. Gastrointestinal stromal tumours: ESMO–EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up

Author

Casali, P.G., Abecassis, N., Bauer, S., Biagini, R., Bielack, S., Bonvalot, S., Boukovinas, I., Bovee, J.V.M.G., Brodowicz, T., Broto, J.M., Buonadonna, A., De Álava, E., Dei Tos, A.P., Del Muro, X.G., Dileo, P., Eriksson, M., Fedenko, A., Ferraresi, V., Ferrari, A., Ferrari, S., Frezza, A.M., Gasperoni, S., Gelderblom, H., Gil, T., Grignani, G., Gronchi, A., Haas, R.L., Hannu, A., Hassan, B., Hohenberger, P., Issels, R., Joensuu, H., Jones, R.L., Judson, I., Jutte, P., Kaal, S., Kasper, B., Kopeckova, K., Krákorová, D.A., Le Cesne, A., Lugowska, I., Merimsky, O., Montemurro, M., Pantaleo, M.A., Piana, R., Picci, P., Piperno-Neumann, S., Pousa, A.L., Reichardt, P., Robinson, M.H., Rutkowski, P., Safwat, A.A., Schöffski, P., Sleijfer, S., Stacchiotti, S., Sundby Hall, K., Unk, M., Van Coevorden, F., Van der Graaf, W., Whelan, J., Wardelmann, E., Zaikova, O., and Blay, J.Y.

Published
2018
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17. IMMUNOSARC: A collaborative Spanish (GEIS) and Italian (ISG) sarcoma groups phase I/II trial of sunitinib plus nivolumab in advanced soft tissue and bone sarcomas: Results of the phase II- soft-tissue sarcoma cohort

Author

Broto, J Martin, primary, Hindi, N., additional, Grignani, G.E., additional, Trufero, J Martinez, additional, Redondo, A., additional, Valverde, C., additional, Pousa, A Lopez, additional, Stacchiotti, S., additional, Palmerini, E., additional, de Alava, E., additional, Moura, D.S., additional, Vega, H Perez, additional, Collini, P., additional, Otero, I., additional, Ledesma, P., additional, Marchesi, E., additional, D’Ambrosio, L., additional, and Martin, J A Lopez, additional

Published
2019
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20. RING1B contributes to Ewing sarcoma development by repressing the Na(V)1.6 sodium channel and the NF-kappa B pathway, independently of the fusion oncoprotein

Author

Hernandez-Muñoz I, Figuerola-Bou E, Sánchez-Molina S, Rodriguez E, Fernández-Mariño AI, Pardo-Pastor C, Bahamonde MI, Fernández-Fernández JM, García-Domínguez DJ, Hontecillas-Prieto L, Lavarino C, Carcaboso AM, de Torres C, Tirado OM, de Alava E, and Mora J

Subjects
NF-?B, voltage-gated sodium channel, RING1B, NF-kappa B, FGFR/SHP2/STAT3, Ewing sarcoma
Abstract

Ewing sarcoma (ES) is an aggressive tumor defined by EWSR1 gene fusions that behave as an oncogene. Here we demonstrate that RING1B is highly expressed in primary ES tumors, and its expression is independent of the fusion oncogene. RING1B-depleted ES cells display an expression profile enriched in genes functionally involved in hematological development but RING1B depletion does not induce cellular differentiation. In ES cells, RING1B directly binds the SCN8A sodium channel promoter and its depletion results in enhanced Nav1.6 expression and function. The signaling pathway most significantly modulated by RING1B is NF-kappa B. RING1B depletion results in enhanced p105/p50 expression, which sensitizes ES cells to apoptosis by FGFR/ SHP2/STAT3 blockade. Reduced Na(V)1.6 function protects ES cells from apoptotic cell death by maintaining low NF-kappa B levels. Our findings identify RING1B as a trait of the cell-of-origin and provide a potential targetable vulnerability.

Published
2016

21. GEIS-21: a multicentric phase II study of intensive chemotherapy including gemcitabine and docetaxel for the treatment of Ewing sarcoma of children and adults: a report from the Spanish sarcoma group (GEIS)

Author

Mora, J, primary, Castañeda, A, additional, Perez-Jaume, S, additional, Lopez-Pousa, A, additional, Maradiegue, E, additional, Valverde, C, additional, Martin-Broto, J, additional, Garcia del Muro, X, additional, Cruz, O, additional, Cruz, J, additional, Martinez-Trufero, J, additional, Maurel, J, additional, Vaz, M A, additional, de Alava, E, additional, and de Torres, C, additional

Published
2017
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24. Bone sarcomas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

Author

Hogendoorn, P. C. W., Athanasou, N., Bielack, S., De Alava, E., Tos, A. P. Dei, Ferrari, S., Gelderblom, H., Grimer, R., Hall, K. Sundby, Hassan, B., Jurgens, H., Paulussen, M., Rozeman, L., Taminiau, A.H.M., Whelan, J., Vanel, D., Hogendoorn, P. C. W., Athanasou, N., Bielack, S., De Alava, E., Tos, A. P. Dei, Ferrari, S., Gelderblom, H., Grimer, R., Hall, K. Sundby, Hassan, B., Jurgens, H., Paulussen, M., Rozeman, L., Taminiau, A.H.M., Whelan, J., and Vanel, D.

Published
2017

25. 1669O - IMMUNOSARC: A collaborative Spanish (GEIS) and Italian (ISG) sarcoma groups phase I/II trial of sunitinib plus nivolumab in advanced soft tissue and bone sarcomas: Results of the phase II- soft-tissue sarcoma cohort

Author

Broto, J Martin, Hindi, N., Grignani, G.E., Trufero, J Martinez, Redondo, A., Valverde, C., Pousa, A Lopez, Stacchiotti, S., Palmerini, E., de Alava, E., Moura, D.S., Vega, H Perez, Collini, P., Otero, I., Ledesma, P., Marchesi, E., D’Ambrosio, L., and Martin, J A Lopez

Published
2019
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26. Desmoplastic small round cell tumor 20 years after its discovery

Author

Mora J, Modak S, Cheung NK, Meyers P, de Alava E, Kushner B, Magnan H, Tirado OM, Laquaglia M, Ladanyi M, and Rosai J

Subjects
desmoplastic tumors, small round cell tumors, EWS gene, WT1 gene, William L Gerald, adolescent and young adult oncology, developmental cancer
Abstract

Desmoplastic small round cell tumor (DSRCT) was proposed as a distinct disease entity by William L Gerald and Juan Rosai in 1991. Over 850 patients have been reported in the medical literature. A specific translocation, t(11;22)(p13;q12), is seen in almost all cases, juxtaposing the EWS gene to the WT1 tumor suppressor gene. DSRCT is composed of nests of small round cells with polyphenotypic differentiation, typically a mixture of epithelial, mesenchymal and neural features, surrounded by a prominent desmoplastic stroma. DSRCT has a predilection for adolescent and young adult males, and primarily involves the abdominal cavity and pelvis. Survival is low despite their initial response to multimodal treatment. Most patients relapse with disseminated disease that is unresponsive to further therapy.

Published
2015

27. Transcripts, Transcripts, Everywhere

Author

de Alava E

Subjects
Text mining, business.industry, In situ hybridization, Computational biology, Anatomy, Biology, Transcription (software), business, Pathology and Forensic Medicine
Published
2001
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29. Ewing Family Tumors

Author

de Alava E, Pardo-Mindán Fj, Lozano, Luis Sierrasesúmaga, and Ana Patiño

Subjects
Male, Pathology, medicine.medical_specialty, Neoplasm, Residual, Adolescent, Oncogene Proteins, Fusion, genetic structures, Bone Neoplasms, Sarcoma, Ewing, Pathology and Forensic Medicine, law.invention, Transcriptional Regulator ERG, law, Ewing family of tumors, medicine, Humans, Neuroectodermal Tumors, Primitive, Prospective Studies, Child, Molecular Biology, Gene, Polymerase chain reaction, DNA Primers, Oncogene Proteins, Proto-Oncogene Protein c-fli-1, Reverse Transcriptase Polymerase Chain Reaction, business.industry, fungi, DNA, Neoplasm, Cell Biology, Neoplastic Cells, Circulating, Prognosis, Minimal residual disease, Molecular biology, Peripheral blood, Reverse transcriptase, DNA-Binding Proteins, Blotting, Southern, Child, Preschool, FLI1, Trans-Activators, Female, sense organs, RNA-Binding Protein EWS, business, Erg, Follow-Up Studies, Transcription Factors
Abstract

In more than 95% of patients, the Ewing family of tumors (ET) has chimeric transcripts caused by fusion of the EWS gene to either FLI1 or ERG. The presence of specific EWS-FLI1 or EWS-ERG transcripts in peripheral blood (PB) samples of patients being treated for ET was prospectively evaluated, and these data were correlated to their clinical status. The authors studied 113 PB samples from 28 patients with ET. Treatment included chemotherapy, radiotherapy, and surgical excision of tumor after induction therapy. PB samples were taken prospectively at least 2 weeks after resection of tumor. Nested reverse-transcriptase polymerase chain reaction (RT-PCR) followed by Southern blot was performed in all samples. Resected tumors were reviewed for the degree of response to chemotherapy and volume. Seventy-seven PB samples from 28 patients had EWS-FLI1/ERG transcripts. In 11 patients, PB samples became negative with treatment, and, in 5 of them, the samples remained negative throughout the study. Samples taken during progression were always positive and, in 4 patients, became positive before progression was clinically evident. All patients with transcripts other than EWS-FLI1 type 1 (n = 3) died from tumor progression. This is a sensitive assay to monitor circulating tumor cells in Ewing tumors. The preliminary data suggest that progression is preceded by positive samples and may be related to specific transcript types.

Published
1998
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30. Corrections to “Soft tissue and visceral sarcomas: ESMO–EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up”

Author

Casali, P.G., Abecassis, N., Aro, H.T., Bauer, S., Biagini, R., Bielack, S., Bonvalot, S., Boukovinas, I., Bovee, J V M G, Brodowicz, T., Broto, J.M., Buonadonna, A., De Álava, E., Dei Tos, A.P., Del Muro, X.G., Dileo, P., Eriksson, M., Fedenko, A., Ferraresi, V., Ferrari, A., Ferrari, S., Frezza, A.M., Gasperoni, S., Gelderblom, H., Gil, T., Grignani, G., Gronchi, A., Haas, R.L., Hassan, B., Hohenberger, P., Issels, R., Joensuu, H., Jones, R.L., Judson, I., Jutte, P., Kaal, S., Kasper, B., Kopeckova, K., Krákorová, D.A., Le Cesne, A., Lugowska, I., Merimsky, O., Montemurro, M., Pantaleo, M.A., Piana, R., Picci, P., Piperno-Neumann, S., Pousa, A.L., Reichardt, P., Robinson, M.H., Rutkowski, P., Safwat, A.A., Schöffski, P., Sleijfer, S., Stacchiotti, S., Sundby Hall, K., Unk, M., Van Coevorden, F., van der Graaf, W.T.A., Whelan, J., Wardelmann, E., Zaikova, O., and Blay, J.Y.

Published
2018
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31. Corrections to “Gastrointestinal stromal tumours: ESMO–EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up”

Author

Casali, P.G., Abecassis, N., Aro, H.T., Bauer, S., Biagini, R., Bielack, S., Bonvalot, S., Boukovinas, I., Bovee, J V M G, Brodowicz, T., Broto, J.M., Buonadonna, A., De Álava, E., Dei Tos, A.P., Del Muro, X.G., Dileo, P., Eriksson, M., Fedenko, A., Ferraresi, V., Ferrari, A., Ferrari, S., Frezza, A.M., Gasperoni, S., Gelderblom, H., Gil, T., Grignani, G., Gronchi, A., Haas, R.L., Hassan, B., Hohenberger, P., Issels, R., Joensuu, H., Jones, R.L., Judson, I., Jutte, P., Kaal, S., Kasper, B., Kopeckova, K., Krákorová, D.A., Le Cesne, A., Lugowska, I., Merimsky, O., Montemurro, M., Pantaleo, M.A., Piana, R., Picci, P., Piperno-Neumann, S., Pousa, A.L., Reichardt, P., Robinson, M.H., Rutkowski, P., Safwat, A.A., Schöffski, P., Sleijfer, S., Stacchiotti, S., Sundby Hall, K., Unk, M., Van Coevorden, F., van der Graaf, W.T.A., Whelan, J., Wardelmann, E., Zaikova, O., and Blay, J.Y.

Published
2018
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33. Treatment of Ewing sarcoma family of tumors with a modified P6 protocol in children and adolescents: Analysis of growth signaling pathways expression and clinical outcome

Author

Mora J, de Torres C, Rodriguez E, Cardesa-Salzmann TM, de Alava E, and Cruz-Martínez O

Abstract

9560 Background: Overall survival (OS) rates of patients with localized Ewing sarcoma family of tumors (ESFT) are >80% when treated with the MSKCC P6 protocol. However, it has been associated with a 5.8% incidence of secondary leukemias. A modified P6 (mP6) protocol with reduced exposure to chemotherapy is presented. The correlation between clinical outcome and the expression of proteins involved in active growth signaling pathways was explored.

Published
2011

34. Soft tissue sarcomas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

Author

Casali, P.G., Blay, J.Y., Aglietta, M., Alvegaard, T., Athanasou, N., Binh, B., Bonvalot, S., Boukovinas, I., De Alava, E., Dei Tos, A.P., Dileo, P., Eriksson, M., Ferrari, A., Ferrari, S., Garcia del Muro, S.F., Gronchi, A., Hall, K.S., Hassan, B., Hogendoorn, P.C., Hohenberger, P., Gelderblom, H., Grimer, R., Issels, R., Joensuu, H., Jost, L., Judson, I.R., Jurgens, H., Cesne, A. le, Leyvraz, S., Martin, J., Montemurro, M., Nishida, T., Patel, S., Reichardt, P., Robinson, M., Rutkowski, P., Schoffski, P., Schlemmer, M., Sleijfer, S., Graaf, W.T.A. van der, Vanel, D., Verweij, J., Wardelmann, E., and Whelan, J.

Subjects
Adult, Male, Radiotherapy, Biopsy, Incidence, Sarcoma, Hematology, Prognosis, soft tissue sarcomas, Combined Modality Therapy, Risk Assessment, Europe, Treatment Outcome, Oncology, Chemotherapy, Adjuvant, Translational research [ONCOL 3], Lymphatic Metastasis, Secondary Prevention, Humans, Female, Neoplasm Metastasis, Follow-Up Studies, Neoplasm Staging, Randomized Controlled Trials as Topic
Abstract

Item does not contain fulltext 01 mei 2010

Published
2010
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36. Bone sarcomas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.

Author

Hogendoorn, P.C., Athanasou, N., Bielack, S., De Alava, E., Dei Tos, A.P., Ferrari, S., Gelderblom, H., Grimer, R., Hall, K.S., Hassan, B., Jurgens, H., Paulussen, M., Rozeman, L., Taminiau, A.H.M., Whelan, J., Vanel, D., Aglietta, M., Alvegaard, T., Binh, B., Blay, J.Y., Bonvalot, S., Boukovinas, I., Casali, P.G., Dileo, P., Eriksson, M., Ferrari, A., Garcia del Muro, S.F., Gronchi, A., Hohenberger, P., Issels, R., Joensuu, H., Jost, L., Judson, I., Cesne, A. le, Leyvraz, S., Martin, J., Montemurro, M., Nishida, T., Patel, S., Reichardt, P., Robinson, M.D., Rutkowski, P., Schoffski, P., Sclemmer, M., Sleijver, S., Graaf, W.T.A. van der, Verweij, J., Wardelmann, E., Hogendoorn, P.C., Athanasou, N., Bielack, S., De Alava, E., Dei Tos, A.P., Ferrari, S., Gelderblom, H., Grimer, R., Hall, K.S., Hassan, B., Jurgens, H., Paulussen, M., Rozeman, L., Taminiau, A.H.M., Whelan, J., Vanel, D., Aglietta, M., Alvegaard, T., Binh, B., Blay, J.Y., Bonvalot, S., Boukovinas, I., Casali, P.G., Dileo, P., Eriksson, M., Ferrari, A., Garcia del Muro, S.F., Gronchi, A., Hohenberger, P., Issels, R., Joensuu, H., Jost, L., Judson, I., Cesne, A. le, Leyvraz, S., Martin, J., Montemurro, M., Nishida, T., Patel, S., Reichardt, P., Robinson, M.D., Rutkowski, P., Schoffski, P., Sclemmer, M., Sleijver, S., Graaf, W.T.A. van der, Verweij, J., and Wardelmann, E.

Abstract

Item does not contain fulltext

Published
2010

37. Gastrointestinal stromal tumours: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.

Author

Casali, P.G., Blay, J.Y., Aglietta, M., Alvegaard, T., Athanasou, N., Binh, B., Bonvalot, S., Boukovinas, I., De Alava, E., Dei Tos, A.P., Dileo, P., Eriksson, M., Ferrari, A., Ferrari, S., Garcia del Muro, S.F., Gronchi, A., Hall, K.S., Hassan, B., Hogendoorn, P.C., Hohenberger, P., Gelderblom, H., Grimer, R., Issels, R., Joensuu, H., Jost, L., Judson, I., Jurgens, H., Cesne, A. le, Leyvraz, S., Martin, J., Montemurro, M., Nishida, T., Patel, S., Reichardt, P., Robinson, M., Rutkowski, P., Schoffski, P., Schlemmer, M., Sleijver, S., Graaf, W.T.A. van der, Vanel, D., Verweij, J., Wardelmann, E., Whelan, J., Casali, P.G., Blay, J.Y., Aglietta, M., Alvegaard, T., Athanasou, N., Binh, B., Bonvalot, S., Boukovinas, I., De Alava, E., Dei Tos, A.P., Dileo, P., Eriksson, M., Ferrari, A., Ferrari, S., Garcia del Muro, S.F., Gronchi, A., Hall, K.S., Hassan, B., Hogendoorn, P.C., Hohenberger, P., Gelderblom, H., Grimer, R., Issels, R., Joensuu, H., Jost, L., Judson, I., Jurgens, H., Cesne, A. le, Leyvraz, S., Martin, J., Montemurro, M., Nishida, T., Patel, S., Reichardt, P., Robinson, M., Rutkowski, P., Schoffski, P., Schlemmer, M., Sleijver, S., Graaf, W.T.A. van der, Vanel, D., Verweij, J., Wardelmann, E., and Whelan, J.

Abstract

1 mei 2010, Item does not contain fulltext

Published
2010

38. International network of cancer genome projects

Author

Hudson, TJ, Anderson, W, Aretz, A, Barker, AD, Bell, C, Bernabe, RR, Bhan, MK, Calvo, F, Eerola, I, Gerhard, DS, Guttmacher, A, Guyer, M, Hemsley, FM, Jennings, JL, Kerr, D, Klatt, P, Kolar, P, Kusuda, J, Lane, DP, Laplace, F, Lu, Y, Nettekoven, G, Ozenberger, B, Peterson, J, Rao, TS, Remacle, J, Schafer, AJ, Shibata, T, Stratton, MR, Vockley, JG, Watanabe, K, Yang, H, Yuen, MMF, Knoppers, M, Bobrow, M, Cambon-Thomsen, A, Dressler, LG, Dyke, SOM, Joly, Y, Kato, K, Kennedy, KL, Nicolas, P, Parker, MJ, Rial-Sebbag, E, Romeo-Casabona, CM, Shaw, KM, Wallace, S, Wiesner, GL, Zeps, N, Lichter, P, Biankin, AV, Chabannon, C, Chin, L, Clement, B, de Alava, E, Degos, F, Ferguson, ML, Geary, P, Hayes, DN, Johns, AL, Nakagawa, H, Penny, R, Piris, MA, Sarin, R, Scarpa, A, van de Vijver, M, Futreal, PA, Aburatani, H, Bayes, M, Bowtell, DDL, Campbell, PJ, Estivill, X, Grimmond, SM, Gut, I, Hirst, M, Lopez-Otin, C, Majumder, P, Marra, M, Ning, Z, Puente, XS, Ruan, Y, Stunnenberg, HG, Swerdlow, H, Velculescu, VE, Wilson, RK, Xue, HH, Yang, L, Spellman, PT, Bader, GD, Boutros, PC, Flicek, P, Getz, G, Guigo, R, Guo, G, Haussler, D, Heath, S, Hubbard, TJ, Jiang, T, Jones, SM, Li, Q, Lopez-Bigas, N, Luo, R, Pearson, JV, Quesada, V, Raphael, BJ, Sander, C, Speed, TP, Stuart, JM, Teague, JW, Totoki, Y, Tsunoda, T, Valencia, A, Wheeler, DA, Wu, H, Zhao, S, Zhou, G, Stein, LD, Lathrop, M, Ouellette, BFF, Thomas, G, Yoshida, T, Axton, M, Gunter, C, McPherson, JD, Miller, LJ, Kasprzyk, A, Zhang, J, Haider, SA, Wang, J, Yung, CK, Cross, A, Liang, Y, Gnaneshan, S, Guberman, J, Hsu, J, Chalmers, DRC, Hasel, KW, Kaan, TSH, Knoppers, BM, Lowrance, WW, Masui, T, Rodriguez, LL, Vergely, C, Cloonan, N, Defazio, A, Eshleman, JR, Etemadmoghadam, D, Gardiner, BA, Kench, JG, Sutherland, RL, Tempero, MA, Waddell, NJ, Wilson, PJ, Gallinger, S, Tsao, M-S, Shaw, PA, Petersen, GM, Mukhopadhyay, D, DePinho, RA, Thayer, S, Muthuswamy, L, Shazand, K, Beck, T, Sam, M, Timms, L, Ballin, V, Ji, J, Zhang, X, Chen, F, Hu, X, Yang, Q, Tian, G, Zhang, L, Xing, X, Li, X, Zhu, Z, Yu, Y, Yu, J, Tost, J, Brennan, P, Holcatova, I, Zaridze, D, Brazma, A, Egevad, L, Prokhortchouk, E, Banks, RE, Uhlen, M, Viksna, J, Ponten, F, Skryabin, K, Birney, E, Borg, A, Borresen-Dale, A-L, Caldas, C, Foekens, JA, Martin, S, Reis-Filho, JS, Richardson, AL, Sotiriou, C, van't Veer, L, Birnbaum, D, Blanche, H, Boucher, P, Boyault, S, Masson-Jacquemier, JD, Pauporte, I, Pivot, X, Vincent-Salomon, A, Tabone, E, Theillet, C, Treilleux, I, Bioulac-Sage, P, Decaens, T, Franco, D, Gut, M, Samuel, D, Zucman-Rossi, J, Eils, R, Brors, B, Korbel, JO, Korshunov, A, Landgraf, P, Lehrach, H, Pfister, S, Radlwimmer, B, Reifenberger, G, Taylor, MD, von Kalle, C, Majumder, PP, Pederzoli, P, Lawlor, RT, Delledonne, M, Bardelli, A, Gress, T, Klimstra, D, Zamboni, G, Nakamura, Y, Miyano, S, Fujimoto, A, Campo, E, de Sanjose, S, Montserrat, E, Gonzalez-Diaz, M, Jares, P, Himmelbaue, H, Bea, S, Aparicio, S, Easton, DF, Collins, FS, Compton, CC, Lander, ES, Burke, W, Green, AR, Hamilton, SR, Kallioniemi, OP, Ley, TJ, Liu, ET, Wainwright, BJ, Hudson, TJ, Anderson, W, Aretz, A, Barker, AD, Bell, C, Bernabe, RR, Bhan, MK, Calvo, F, Eerola, I, Gerhard, DS, Guttmacher, A, Guyer, M, Hemsley, FM, Jennings, JL, Kerr, D, Klatt, P, Kolar, P, Kusuda, J, Lane, DP, Laplace, F, Lu, Y, Nettekoven, G, Ozenberger, B, Peterson, J, Rao, TS, Remacle, J, Schafer, AJ, Shibata, T, Stratton, MR, Vockley, JG, Watanabe, K, Yang, H, Yuen, MMF, Knoppers, M, Bobrow, M, Cambon-Thomsen, A, Dressler, LG, Dyke, SOM, Joly, Y, Kato, K, Kennedy, KL, Nicolas, P, Parker, MJ, Rial-Sebbag, E, Romeo-Casabona, CM, Shaw, KM, Wallace, S, Wiesner, GL, Zeps, N, Lichter, P, Biankin, AV, Chabannon, C, Chin, L, Clement, B, de Alava, E, Degos, F, Ferguson, ML, Geary, P, Hayes, DN, Johns, AL, Nakagawa, H, Penny, R, Piris, MA, Sarin, R, Scarpa, A, van de Vijver, M, Futreal, PA, Aburatani, H, Bayes, M, Bowtell, DDL, Campbell, PJ, Estivill, X, Grimmond, SM, Gut, I, Hirst, M, Lopez-Otin, C, Majumder, P, Marra, M, Ning, Z, Puente, XS, Ruan, Y, Stunnenberg, HG, Swerdlow, H, Velculescu, VE, Wilson, RK, Xue, HH, Yang, L, Spellman, PT, Bader, GD, Boutros, PC, Flicek, P, Getz, G, Guigo, R, Guo, G, Haussler, D, Heath, S, Hubbard, TJ, Jiang, T, Jones, SM, Li, Q, Lopez-Bigas, N, Luo, R, Pearson, JV, Quesada, V, Raphael, BJ, Sander, C, Speed, TP, Stuart, JM, Teague, JW, Totoki, Y, Tsunoda, T, Valencia, A, Wheeler, DA, Wu, H, Zhao, S, Zhou, G, Stein, LD, Lathrop, M, Ouellette, BFF, Thomas, G, Yoshida, T, Axton, M, Gunter, C, McPherson, JD, Miller, LJ, Kasprzyk, A, Zhang, J, Haider, SA, Wang, J, Yung, CK, Cross, A, Liang, Y, Gnaneshan, S, Guberman, J, Hsu, J, Chalmers, DRC, Hasel, KW, Kaan, TSH, Knoppers, BM, Lowrance, WW, Masui, T, Rodriguez, LL, Vergely, C, Cloonan, N, Defazio, A, Eshleman, JR, Etemadmoghadam, D, Gardiner, BA, Kench, JG, Sutherland, RL, Tempero, MA, Waddell, NJ, Wilson, PJ, Gallinger, S, Tsao, M-S, Shaw, PA, Petersen, GM, Mukhopadhyay, D, DePinho, RA, Thayer, S, Muthuswamy, L, Shazand, K, Beck, T, Sam, M, Timms, L, Ballin, V, Ji, J, Zhang, X, Chen, F, Hu, X, Yang, Q, Tian, G, Zhang, L, Xing, X, Li, X, Zhu, Z, Yu, Y, Yu, J, Tost, J, Brennan, P, Holcatova, I, Zaridze, D, Brazma, A, Egevad, L, Prokhortchouk, E, Banks, RE, Uhlen, M, Viksna, J, Ponten, F, Skryabin, K, Birney, E, Borg, A, Borresen-Dale, A-L, Caldas, C, Foekens, JA, Martin, S, Reis-Filho, JS, Richardson, AL, Sotiriou, C, van't Veer, L, Birnbaum, D, Blanche, H, Boucher, P, Boyault, S, Masson-Jacquemier, JD, Pauporte, I, Pivot, X, Vincent-Salomon, A, Tabone, E, Theillet, C, Treilleux, I, Bioulac-Sage, P, Decaens, T, Franco, D, Gut, M, Samuel, D, Zucman-Rossi, J, Eils, R, Brors, B, Korbel, JO, Korshunov, A, Landgraf, P, Lehrach, H, Pfister, S, Radlwimmer, B, Reifenberger, G, Taylor, MD, von Kalle, C, Majumder, PP, Pederzoli, P, Lawlor, RT, Delledonne, M, Bardelli, A, Gress, T, Klimstra, D, Zamboni, G, Nakamura, Y, Miyano, S, Fujimoto, A, Campo, E, de Sanjose, S, Montserrat, E, Gonzalez-Diaz, M, Jares, P, Himmelbaue, H, Bea, S, Aparicio, S, Easton, DF, Collins, FS, Compton, CC, Lander, ES, Burke, W, Green, AR, Hamilton, SR, Kallioniemi, OP, Ley, TJ, Liu, ET, and Wainwright, BJ

Abstract

The International Cancer Genome Consortium (ICGC) was launched to coordinate large-scale cancer genome studies in tumours from 50 different cancer types and/or subtypes that are of clinical and societal importance across the globe. Systematic studies of more than 25,000 cancer genomes at the genomic, epigenomic and transcriptomic levels will reveal the repertoire of oncogenic mutations, uncover traces of the mutagenic influences, define clinically relevant subtypes for prognosis and therapeutic management, and enable the development of new cancer therapies.

Published
2010

41. The calcium-sensing receptor is silenced by genetic and epigenetic mechanisms in unfavorable neuroblastomas and its reactivation induces ERK1/2-dependent apoptosis

Author

Casalà, C., primary, Gil-Guiñón, E., additional, Ordóñez, J.L., additional, Miguel-Queralt, S., additional, Rodríguez, E., additional, Galván, P., additional, Lavarino, C., additional, Munell, F., additional, de Alava, E., additional, Mora, J., additional, and de Torres, C., additional

Published
2012
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42. In vitro and in vivo rationale for the triple combination of panobinostat (LBH589) and dexamethasone with either bortezomib or lenalidomide in multiple myeloma

Author

Ocio, E. M., primary, Vilanova, D., additional, Atadja, P., additional, Maiso, P., additional, Crusoe, E., additional, Fernandez-Lazaro, D., additional, Garayoa, M., additional, San-Segundo, L., additional, Hernandez-Iglesias, T., additional, de Alava, E., additional, Shao, W., additional, Yao, Y. M., additional, Pandiella, A., additional, and San-Miguel, J. F., additional

Published
2009
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43. Stable interference of EWS–FLI1 in an Ewing sarcoma cell line impairs IGF-1/IGF-1R signalling and reveals TOPK as a new target

Author

Herrero-Martín, D, primary, Osuna, D, additional, Ordóñez, J L, additional, Sevillano, V, additional, Martins, A S, additional, Mackintosh, C, additional, Campos, M, additional, Madoz-Gúrpide, J, additional, Otero-Motta, A P, additional, Caballero, G, additional, Amaral, A T, additional, Wai, D H, additional, Braun, Y, additional, Eisenacher, M, additional, Schaefer, K-L, additional, Poremba, C, additional, and de Alava, E, additional

Published
2009
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47. 227P - Prognosis of Phosphorylated-Insulin Growth Factor Receptor (P-Igf-1R) and Metalloproteinase-3 (Mmp3) Expression in Advanced Gastrointestinal Stromal Tumors (Gist) Patients Treated with Imatinib. a Geis Study

Author

Maurel, J., Lopez-Pousa, A., Calabuig, S., Bagué, S., Del Muro, X. García, Sanjuan, X., Rubió, J., Cuatrecasas, M., Martinez-Trufero, J., Horndler, C., Fra, J., Morales, C. Valverde, Redondo, A., Poveda, A.M., Sevilla, I., Lainez, N., Rubini, M., Albéniz, X. García, Broto, J. Martin, and De Álava, E.

Published
2014
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49. Adenovirus E1A and Ewing tumors

Author

de Alava, E., Sanchez-Prieto, R., and Ramon y Cajal, S.

Abstract

In the December 1999 issue of Nature Medicine, Melot and Delattre and Kovar, challenged the Sanchez-Prieto et al . September 1999 article proposing that the adenoviral E1A gene induces the Ewing tumor fusion transcript EWS-FLI1. Here Sanchez-Prieto et al. respond...Ed., Author(s): E. de Alava [1]; R. Sanchez-Prieto [2]; S. Ramon y Cajal [2] Sanchez-Prieto et al. reply Both letters question the association between E1A and EWS-FLI1 by studying HEK293 cells [...]

Published
2000
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