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The Balloon Experiment for Galactic INfrared Science (BEGINS) is a concept for a sub-orbital observatory that will operate from λ\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\lambda$$\end{document} = 25 to 250 μ\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\upmu$$\end{document}m to characterize dust in the vicinity of high-mass stars. The mission’s sensitivity requirements will be met by utilizing arrays of 1840 lens-coupled, lumped-element kinetic inductance detectors (KIDs) operating at 300 mK. Each KID will consist of a titanium nitride (TiN) parallel strip absorbing inductive section and parallel plate capacitor deposited on a Silicon (Si) substrate. The parallel plate capacitor geometry allows for reduction of the pixel spacing. At the BEGINS focal plane, the detectors require optical NEPs from 2×10-16\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$2\times 10^{-16}$$\end{document} to 6×10-17\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$6\times 10^{-17}$$\end{document} W/Hz\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\sqrt{\text {Hz}}$$\end{document} from 25 to 250 μ\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\upmu$$\end{document}m for optical loads ranging from 4 to 10 pW. We present the design, optical performance and quasiparticle lifetime measurements of a prototype BEGINS KID array at 25 μ\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\upmu$$\end{document}m when coupled to Fresnel zone plate lenses. For our optical set up and the absorption efficiency of the KIDs, the electrical NEP requirement at 25 μ\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\upmu$$\end{document}m is 7.6×10-17\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$7.6\times 10^{-17}$$\end{document} W/Hz\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\sqrt{\text {Hz}}$$\end{document} for an absorbed optical power of 0.36 pW. We find that over an average of five resonators the the detectors are photon noise limited down to about 200 fW, with a limiting NEP of about 7.4×10-17\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$7.4\times 10^{-17}$$\end{document} W/Hz\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\sqrt{\text {Hz}}$$\end{document}. Future arrays will be coupled to microlens arrays and have higher optical efficiencies. [ABSTRACT FROM AUTHOR]

If driven sufficiently strongly, superconducting microresonators exhibit nonlinear behavior including response bifurcation. This behavior can arise from a variety of physical mechanisms including heating effects, grain boundaries or weak links, vortex penetration, or through the intrinsic nonlinearity of the kinetic inductance. Although microresonators used for photon detection are usually driven fairly hard in order to optimize their sensitivity, most experiments to date have not explored detector performance beyond the onset of bifurcation. Here, we present measurements of a lumped-element superconducting microresonator designed for use as a far-infrared detector and operated deep into the nonlinear regime. The 1 GHz resonator was fabricated from a 22 nm thick titanium nitride film with a critical temperature of 2 K and a normal-state resistivity of 100 μΩ cm. We measured the response of the device when illuminated with 6.4 pW optical loading using microwave readout powers that ranged from the low-power, linear regime to 18 dB beyond the onset of bifurcation. Over this entire range, the nonlinear behavior is well described by a nonlinear kinetic inductance. The best noise-equivalent power of 2×10-16 W/Hz1/2 at 10 Hz was measured at the highest readout power, and represents a ∼10 fold improvement compared with operating below the onset of bifurcation. [ABSTRACT FROM AUTHOR]

The recombination rate of quasiparticle excitations and metal film thickness are both important factors in determining the sensitivity of kinetic inductance detectors (KIDs). To maximize KID sensitivity, we aim to quantify the interdependence of these two detector attributes. We have measured the decay times of optical pulses produced by illuminating aluminum CPW resonators with an infrared LED. Measurements were made using both 1/4-wavelength and 1/2-wavelength resonators for film thicknesses between 20 and 50 nm for a range of temperatures and microwave readout powers. We observed several millisecond decay times for all thicknesses, with an elevated decay time (∼ 5 ms) and critical temperature (∼ 1.5 K) for the 20-nm-thick film. [ABSTRACT FROM AUTHOR]

Over the last few years, there has been a growing interest toward the use of superconducting microwave microresonators operated in quasi-thermal equilibrium mode, especially applied to single particle detection. Indeed, previous devices designed and tested by our group with X-ray sources in the keV range evidenced that several issues arise from the attempt of detection through athermal quasiparticles produced within direct strikes of X-rays in the superconductor material of the resonator. In order to prevent issues related to quasiparticles self-recombination and to avoid exchange of athermal phonons with the substrate, our group focused on the development of thermal superconducting microresonators. In this configuration, resonators composed of multilayer films of Ti/TiN sense the temperature of an absorbing material. To maximize the thermal response, low-critical-temperature films are preferable. By lowering the critical temperature, though, the maximum probing power bearable by the resonators decreases abruptly because of the weakening of the electron-phonon coupling. A proper compromise between the value of critical temperature (and hence sensitivity to energy deposition) and readout power bearable by the device has to be found in order to avoid signal-to-noise ratio degradation. In this contribution, we report the latest measurement of the electron-phonon coupling. [ABSTRACT FROM AUTHOR]

Abstract: Introduction: Dental treatment for children requires not only technical skills, but also the knowledge and confidence to provide behaviour management to support children of differing ages and stages of development. It is not surprising then that dental students find treating children especially stressful. Paediatric dentistry training is therefore a vital element of the undergraduate dental curriculum. Materials and Methods: Eighty‐six fourth‐year undergraduate dental students received standard lectures and seminars about behaviour management techniques for children having local anaesthetic. The students were then randomly divided into groups using cluster randomisation. The intervention group received an intervention‐based around video clips (VCs) demonstrating behaviour management techniques (BMTs) for children receiving local anaesthetic The intervention and control groups completed self‐administered questionnaires to determine their level of confidence in managing local anaesthetic for children. Results: There was a statistically significant difference in the level of confidence between the groups immediately after the teaching intervention (P=.003) and at 4 months (P=.001) in favour of the video group. Discussion: Previous studies on the use of video as a teaching aid have reported favourable results in terms of both student attitudes and learning outcomes. The results from this study confirm the benefits of this style of teaching paediatric behaviour skills in the undergraduate dental curriculum, and the benefits were maintained at 4 months. Conclusion: This study has demonstrated that VCs as an additional teaching aid are an effective method in improving students’ confidence for BMTs when delivering local anaesthetic. [ABSTRACT FROM AUTHOR]

Background: L-β-N-methylamino-l-alanine (BMAA) is a non-proteinic amino acid, that is neurotoxic in vitro and in animals, and is implicated in the causation of amyotrophic lateral sclerosis and parkinsonism-dementia complex (ALS-PDC) on Guam. Given that natural amino acids can be N-nitrosated to form toxic alkylating agents and the structural similarity of BMAA to other amino acids, our hypothesis was that N-nitrosation of BMAA might result in a toxic alkylating agent, providing a novel mechanistic hypothesis for BMAA action. Findings: We have chemically nitrosated BMAA with sodium nitrite to produce nitrosated BMAA (N-BMAA) which was shown to react with the alkyl-trapping agent, 4-(p-nitrobenzyl)pyridine, cause DNA strand breaks in vitro and was toxic to the human neuroblastoma cell line SH-SY5Y under conditions in which BMAA itself was minimally toxic. Conclusions: Our results indicate that N-BMAA is an alkylating agent and toxin suggesting a plausible and previously unrecognised mechanism for the neurotoxic effects of BMAA. [ABSTRACT FROM AUTHOR]

We describe a novel class of devices based on the nonlinearity of the kinetic inductance of a superconducting thin film. By placing a current-dependent inductance in a microwave resonator, small currents can be measured through their effect on the resonator's frequency. By using a high-resistivity material for the film and nanowires as kinetic inductors, we can achieve a large coefficient of nonlinearity to improve device sensitivity. We demonstrate a current sensitivity of $$8{\text {pA/}}\sqrt{{\text {Hz}}}$$ , making this device useful for transition-edge sensor (TES) readout and other cutting-edge applications. An advantage of these devices is their natural ability to be multiplexed in the frequency domain, enabling large detector arrays for TES-based instruments. A traveling-wave version of the device, consisting of a thin-film microwave transmission line, is also sensitive to small currents as they change the phase length of the line due to their effect on its inductance. We demonstrate a current sensitivity of $$5{\text {pA/}}\sqrt{{\text {Hz}}}$$ for this version of the device, making it also suitable for TES readout as well as other current-detection applications. It has the advantage of multi-GHz bandwidth and greater dynamic range, offering a different approach to the resonator version of the device. [ABSTRACT FROM AUTHOR]

The European Research Council has recently funded HOLMES, a project with the aim of performing a calorimetric measurement of the electron neutrino mass measuring the energy released in the electron capture decay of Ho. The baseline for HOLMES are microcalorimeters coupled to transition edge sensors read-out with rf-SQUIDs, for microwave multiplexing purposes. A promising alternative solution is based on superconducting microwave resonators that have undergone rapid development in the last decade. These detectors, called Microwave Kinetic Inductance Detectors (MKIDs), are inherently multiplexed in the frequency domain and suitable for even larger-scale pixel arrays, with theoretical high energy resolution and fast response. The aim of our activity is to develop arrays of microresonator detectors for X-ray spectroscopy and suitable for the calorimetric measurement of the energy spectra of Ho. Superconductive multilayer films composed by a sequence of pure Titanium and stoichiometric TiN layers show many ideal properties for MKIDs, such as low loss, large sheet resistance, large kinetic inductance, and tunable critical temperature $$T_\mathrm{c}$$ . We developed Ti/TiN multilayer microresonators with $$T_\mathrm{c}$$ within the range from 70 mK to 4.5 K and with good uniformity. In this contribution, we present the design solutions adopted, the fabrication processes, and the characterization results. [ABSTRACT FROM AUTHOR]

Background: Alternative materials for antibiotics used in white leg shrimp farming were extensively investigated. The promising effects of plant based extracts in controlling aquaculture diseases has been reported elsewhere. This study was conducted to examine the effect of Solanum procumbens Lour. extract on survival, growth performance, innate immunity and protection against acute hepatopancreas necrosis disease caused by Vibrio parahaemolyticus (VpAHPND) in white leg shrimp. Methods: From March 2021 to September 2021, four difference diets were examined including the supplementation of S. procumbens L. extract at 0.0%, 0.5%, 1.0% and 1.5%. After 30 days of culture, the experimental shrimp was examined for survival rate, growth responses, innate immune parameters and mortality as challenged with VpAHPND. Result: The results indicated shrimp fed diets with and without S. procumbens L. extract supplementation showed no significant differences in survival and growth performances. However, the innate immune parameters were likely increased in shrimp fed diets at 1.0% and 1.5% extract supplementation and shrimp fed diets at 1.0% and 1.5% extract supplementation reduced the accumulate mortality of VpAHPND challenged shrimp by 47.6%. S. procumbens L. could be a potential material for enhancing innate immunity of white leg shrimp and can protect shrimp from AHPND infection. [ABSTRACT FROM AUTHOR]

Background: Dental caries in young children is a major public health problem impacting on the child and their family in terms of pain, infection and substantial financial burden on healthcare funders. In the UK, national guidance on the prevention of dental caries advises parents to supervise their child's brushing with fluoride toothpaste until age 7. However, there is a dearth of evidence-based interventions to encourage this practice in parents. The current study used intervention mapping (IM) to develop a home-based parental-supervised toothbrushing intervention to reduce dental caries in young children.Methods: The intervention was developed using the six key stages of the IM protocol: (1) needs assessment, including a systematic review, qualitative interviews, and meetings with a multi-disciplinary intervention development group; (2) identification of outcomes and change objectives following identification of the barriers to parental-supervised toothbrushing (PSB), mapped alongside psychological determinants outlined in the Theoretical Domains Framework (TDF); (3) selection of methods and practical strategies; (4) production of a programme plan; (5) adoption and implementation and (6) Evaluation.Results: The comprehensive needs assessment highlighted key barriers to PSB, such as knowledge, skills, self-efficacy, routine setting and behaviour regulation and underlined the importance of individual, social and structural influences. Parenting skills (routine setting and the ability to manage the behaviour of a reluctant child) were emphasised as critical to the success of PSB. The multi-disciplinary intervention development group highlighted the need for both universal and targeted programmes, which could be implemented within current provision. Two intervention pathways were developed: a lower cost universal pathway utilising an existing national programme and an intensive targeted programme delivered via existing parenting programmes. A training manual was created to accompany each intervention to ensure knowledge and standardise implementation procedures.Conclusions: PSB is a complex behaviour and requires intervention across individual, social and structural levels. IM, although a time-consuming process, allowed us to capture this complexity and allowed us to develop two community-based intervention pathways covering both universal and targeted approaches, which can be integrated into current provision. Further research is needed to evaluate the acceptability and sustainability of these interventions. [ABSTRACT FROM AUTHOR]

Far-infrared (far-IR) astrophysics missions featuring actively cooled telescopes will offer orders of magnitude observing speed improvement at wavelengths where galaxies and forming planetary systems emit most of their light. The PRobe far-Infrared Mission for Astrophysics (PRIMA), which is currently under study, emphasizes low- and moderate-resolution spectroscopy throughout the far-IR. Full utilization of PRIMA's cold telescope requires far-IR detector arrays with per-pixel noise equivalent powers (NEPs) at or below 1 × 10 - 19 W / Hz . We are developing low-volume aluminum kinetic inductance detector (KID) arrays to reach these sensitivities. We describe the development of our long-wavelength (80–265 μ m ) array approach and present multitone measurements of a 1008-pixel arrays. We measure an NEP below 1 × 10 - 19 W / Hz for 73% of the measured pixels. [ABSTRACT FROM AUTHOR]

Future space-based far-infrared astrophysical observatories will require exquisitely sensitive detectors consistent with the low optical backgrounds. The PRobe far-Infrared Mission for Astrophysics (PRIMA) will deploy arrays of thousands of superconducting kinetic inductance detectors (KIDs) sensitive to radiation between 25 and 265 μ m. Here, we present laboratory characterization of prototype, 25–80- μ m wavelength, low-volume, aluminum KIDs designed for the low-background environment expected with PRIMA. A compact parallel plate capacitor is used to minimize the detector footprint and suppress TLS noise. A novel resonant absorber is designed to enhance response in the band of interest. We present noise and optical efficiency measurements of these detectors taken with a low-background cryostat and a cryogenic blackbody. A microlens-hybridized KID array is found to be photon noise limited down to about 50 aW with a limiting detector NEP of about 6.5 × 10 - 19 W/Hz 1 / 2 . A fit to an NEP model shows that our optical system is well characterized and understood down to 50 aW. We discuss future plans for low-volume aluminum KID array development as well as the testbeds used for these measurements. [ABSTRACT FROM AUTHOR]

We present our current progress on the design and test of Ti/TiN multilayer for use in kinetic inductance detectors. Sensors based on sub-stoichiometric TiN film are commonly used in several applications. However, it is difficult to control the targeted critical temperature $$T_c$$ , to maintain precise control of the nitrogen incorporation process and to obtain a production uniformity. To avoid these problems we investigated multilayer Ti/TiN films that show a high uniformity coupled with high quality factor, kinetic inductance and inertness of TiN. These features are ideal to realize superconductive microresonator detectors for astronomical instruments application but also for the field of neutrino physics. Using pure Ti and stoichiometric TiN, we developed and tested different multilayer configurations, in terms of number of Ti/TiN layers and in terms of different interlayer thicknesses. The target was to reach a critical temperature $$T_c$$ around $$(1{\div } 1.5)$$ K in order to have a low energy gap and slower recombination time (i.e. low generation-recombination noise). The results prove that the superconductive transition can be tuned in the $$(0.5{\div } 4.6)$$ K temperature range by properly choosing the Ti thickness in the $$(0{\div } 15)$$ nm range, and the TiN thickness in the $$(5{\div } 100)$$ nm range. [ABSTRACT FROM AUTHOR]

The determination of the neutrino mass is still an open issue in particle physics. The calorimetric measurement of the energy released in a nuclear beta decay allows to measure all the released energy, except the fraction carried away by the neutrino: a finite neutrino mass m $$_\upnu $$ causes the energy spectrum to be truncated at Q $$-$$ m $$_\upnu $$ , where Q is the transition energy. The electron capture of $$^{163}$$ Ho (Q $$\sim $$ 2.5 keV) results to be an ideal decay. In order to achieve enough statistics, a large number of detectors ( $$\sim $$ 10 $$^4$$ ) is required. Superconducting microwave microresonators are detectors suitable for large-scale multiplexed frequency domain readout, with theoretical energy and time resolution of $$\sim $$ eV and $$\sim \!\upmu $$ s. Our aim is to develop arrays of microresonator detectors applicable to the calorimetric measurement of the energy spectra of $$^{163}$$ Ho. Currently, a study aimed to the selection of the best design and material for the detectors is in progress. In this contribution, a comparison between the measurements (critical temperature, gap parameter, quasiparticle recombination time and X-ray energy spectra) made with stoichiometric, sub-stoichiometric TiN and Ti/TiN multilayer films are presented. [ABSTRACT FROM AUTHOR]

Day PF, Lewis BRK, Spencer RJ, Barber SK, Duggal M. The design and development of surgical templates for premolar transplants in adolescents. International Endodontic Journal., 45, 1042-1052, 2012. Abstract The aim of designing and fabricating the surgical templates was to assist the surgical component of premolar transplantation, by establishing and replicating the root dimensions of the donor premolar tooth. The correct template could be used to assess the socket preparation (width and depth) prior to placement of the transplant in the recipient site, obviating the need to repeatedly try the donor tooth for fit at the recipient site, thereby minimising trauma to the periodontal ligament of the donor tooth. Seventy-five mandibular premolars and 50 maxillary second premolars were selected with varying stages of root development. All teeth had been extracted for orthodontic reasons. The root was measured for its length (maxL) and maximum (maxW) and minimum width (minW) with digital callipers from standardised reference points. These measurements were then used in the design of premolar transplant templates. The mean measurements for second maxillary premolars were maxL 14.6 mm (±1.7), maxW 8.3 mm (±0.5) and minW 4.9 (±0.3). The mean measurements for mandibular premolars were maxL 14.8 (±1.6), maxW 7.4 (±0.6) and minW 5.3 (±0.5). From these measurements, a range of maxillary second premolar and mandibular premolar templates have been fabricated. These figures also inform the multidisciplinary planning process for the space requirements at the donor site prior to transplantation. [ABSTRACT FROM AUTHOR]

Clinically, keloids are defined as scars that invade adjacent healthy tissue and are caused by tissue injury; however, the clear distinction relating keloids to wound healing or to cancer remains elusive. This study profiled protein extracts from the regions of keloid tissues to determine the activities within these different zones, and to help underpin the activities apparent within different regions of the disease. Two-dimensional gel electrophoresis, liquid chromatography mass spectrometer (LCMS) and a Mascot online database search were employed for comparative proteomic analysis between four sites in keloidal scars (KS). Out of 400 spots identified in all gels, 21 were unique to given KS sites. These were identified using LCMS and the results showed the presence of mitochondrial and structural proteins in the margin, while the top contained keratin II. Heat shock protein was the only protein present in the internal normal control and margin, while the external normal contain keratin II and the voltage-dependent anion-selective channel protein, annexin A6, plus glial fibrillary acidic protein. This work is novel since it has identified differentially expressed proteins across the tested keloidal scar sites. The presence of mitochondrial-associated proteins at the margins suggests that this is the most active part of the scar. [ABSTRACT FROM AUTHOR]

Superconducting microwave microresonators are low temperature detectors which are compatible with large-scale multiplexed frequency domain readout. We aim to adapt and further advance the technology of microresonator detectors to develop new devices applied to the problem of measuring the neutrino mass. More specifically, we aim to develop detector arrays for calorimetric measurement of the energy spectra of Ho EC decay ( Q∼2-3 keV) for a direct measurement of the neutrino mass. In order to achieve these goal, we need to find the best design and materials for the detectors. A recent advance in microwave microresonator technology was the discovery that some metal nitrides, such as TiN, possess properties consistent with very high detector sensitivity. We plan to investigate nitrides of higher-Z materials, for example TaN and HfN, that are appropriate for containing the energy of keV decay events, exploring the properties relevant to our detectors, such as quality factor, penetration depth and recombination time. [ABSTRACT FROM AUTHOR]

Using a noise thermometry technique, we measured the temperature dependence of the heat capacity C(T) of suspended SixNy membranes for two different geometries from 30 mK to 300 mK. We determined a volumetric specific heat of the SixNy on the order of 10 aJ/(μm3 K) at 0.1 K for both absorber geometries. This value for the specific heat is comparable to a typical metal and is more than a factor of 10 larger than typical glassy materials. This result affects the design of highly efficient optical absorbers for membrane-isolated transition-edge sensors (TESs) for the Background-Limited far-IR/Submillimeter Spectrograph (BLISS), a proposed grating spectrometer that could fly on the next generation of large, cryogenic space-borne telescopes. We show that it is possible to reduce the thermal mass of the absorber of TESs so the effective response time re Te less than 100 ms-a requirement for all the wavelength bands for BLISS. [ABSTRACT FROM AUTHOR]

Objective: The aim of this study was to identify clusters of nations grouped by health outcomes in order to provide sensible groupings for international comparisons. The utility of this approach is demonstrated by comparing life expectancy and a range of health system indicators within and between each cluster. Methods: Age- and sex-specific mortality data for 190 member states were extracted from the Burden of Disease Estimates statistics produced by the World Health Organization. A hierarchical cluster method was used to identify groupings of countries that are homogeneous in terms of mortality rates. Results: 12 clusters of countries were identified. The average life expectancy of each cluster ranged from 81.5 years (cluster 1) to 37.7 years (cluster 12(. The two highest ranked clusters were dominated by Western European countries, Australia, Japan and Canada. Cluster 3 included the UK and USA. The four clusters with the lowest life expectancies were characterised by different configurations of African countries. Health system indicators for workforce, hospital beds, access to medicines and measles vaccination corresponded well with a clear association with cluster life expectancy. On a per capita basis, worldwide health spending was concentrated within the three highest life expectancy clusters, especially cluster 3 containing the USA. Conclusions: Considerable inequalities in life expectancy and healthcare are made clearer when viewed across clusters of countries grouped by health outcomes. This geo-demographic taxonomy of global mortality has advantages over traditional more ad hoc systems for comparing global health inequalities and for deciding which countries appear to have the most comparable health outcomes. [ABSTRACT FROM AUTHOR]

The Superconducting Quantum Interference Device (SQUID) has been used and proposed often to read out low-temperature detectors for astronomical instruments. A multiplexed SQUID readout for currently envisioned astronomical detector arrays, which will have tens of thousands of pixels, is still challenging with the present technology. We present a new, advanced multiplexing concept and its prototype development that will allow for the readout of 1,000–10,000 detectors with only three pairs of wires and a single microwave coaxial cable. [ABSTRACT FROM AUTHOR]

Pottery from the Late Minoan I kiln at Haghia Triada in the Mesara Plain, southern Crete, was analysed by a range of techniques, comprising thin-section petrography, scanning electron microscopy, X-ray diffraction, X-ray fluorescence and neutron activation analysis. The project characterizes the ceramic fabrics and probable raw materials, correlates paste recipes with shape, reconstructs the firing conditions of the kiln and establishes a chemical reference group, taking into account post-burial alteration and contamination. Comparison of the reference group formed with that from the neighbouring, broadly contemporary, kiln at Kommos shows an unexpected differentiation of the two kilns. [ABSTRACT FROM AUTHOR]

The calcareous skeletal remains of various microscopic organisms such as foraminifera and ostracods are a striking feature of thin sections of many archaeological ceramics from the Aegean Bronze Age. While the presence of these calcareous microfossils in pottery has been noted for some time, attempts to utilize them to further the aims of ceramic compositional analysis have been few in number. In the following paper, we take a first detailed look at the occurrence and utility of calcareous microfossils in archaeological ceramics. By presenting selected case studies from the Bronze Age of Crete, we demonstrate the potential of calcareous microfossils, especially the extremely small ‘nannofossils’ and the highly contextual geological information that they contain, in terms of the characterization and grouping of ceramics, the determination of their provenance and the reconstruction of ancient technology. [ABSTRACT FROM AUTHOR]

A survey was sent to laboratories participating in the United Kingdom External Quality Assessment Service (UKNEQAS) Haematinics Scheme about the measurement of serum erythropoietin (EPO). Six laboratories, from a total of 120 that returned the survey, were measuring serum EPO concentrations by commercially available immunoassays on site in the United Kingdom. The workload of the laboratories varied from up to 100 specimens per month to more than 100 specimens analysed per week. All laboratories included control material in the assays and none of the laboratories was participating in an external quality assessment scheme for serum EPO. Four laboratories agreed to take part in the first sample distribution programme, with five and six laboratories participating in distributions 2 and 3 respectively. The results from eight kits were compared from the three distributions over a 2-year period. The serum EPO concentrations for the methods showed some variation across the range of 2.9–200 U/l when the serum EPO concentrations for each method were compared with the whole method mean. The results from this scheme have identified a role for an external quality assessment scheme for serum EPO measurements. [ABSTRACT FROM AUTHOR]

The determination of provenance probably forms the primary role of geochemical analyses in archaeological ceramic studies. In what has comprised a successful field of study, the ultimate basis for such research has been the comparison of pottery compositions with the geochemical diversity displayed by clay deposits within a given study area. Although such studies are now common, the understanding of chemical and mineralogical variability in ceramic raw materials has been somewhat neglected, with the dominance of assumptions rather than the actual analysis of clays. In this paper, a study is presented of Neogene clays in Crete (Greece), a clay type commonly used in ancient and modern pottery production. Sixty-one samples were taken from 28 locations in the central and eastern parts of the island, to reveal both intra- and inter-deposit variability.In one deposit chosen for multiple sampling, the 14 samples display great variability in the alkali elements, Fe and Co, and to a lesser extent in the REEs. Many of the geographically separate deposits differ from each other in chemical composition, with Eastern Cretan deposits showing higher REE concentrations and higher Th/Sc ratios, whereas Central Cretan deposits of younger geological stages are characterized by a lower Th/U ratio. Mineralogical analysis by XRD is used to explain aspects of the geochemical variability of the clays. [ABSTRACT FROM AUTHOR]

Reports on the GEM general materials diffractometer project at ISIS pulsed neutron source. Aim of the project; Range of materials that is being made on the GEM instrument; Objectives of the GEM design; Considerations to the design of the diffractometer.

Valvular disease in pediatric donor hearts may be a relative contraindication to graft use. Outcomes following use of donor hearts with milder forms of valvular disease have not been previously reported. We describe 4 cases of pediatric heart transplantation (HTx) in which the donor heart had a bicuspid aortic valve (BAV). Of the 469 HTx performed at our center since 1985, 4 donor hearts had a BAV. All recipients were female; median age 11 years (range 0.3 to 19 years). In all cases, the BAV was not discovered until after HTx. All donors were less than 30 years old. The patients were followed for a median of 6 years (range 2 to 9 years) with all patients alive at last follow up. Two patients transferred to adult care and 2 patients are followed by our clinic. In follow up, no patient required an aortic valve intervention or had infective endocarditis. At last review, no patient had greater than mild aortic insufficiency or more than mild aortic stenosis. Three patients developed mild to moderate left ventricular hypertrophy in the first year post-transplant that improved over time. One patient experienced a peri-operative embolic stroke at time of transplant unrelated to the bicuspid aortic valve. On short- and intermediate-term follow up, donor hearts with bicuspid aortic valve demonstrated acceptable graft longevity and valvular function. A functionally normal bicuspid aortic valve in a pediatric heart transplant donor should not be a contraindication to organ acceptance. [ABSTRACT FROM AUTHOR]

There has been much discussion about the changes introduced by the Government in 1989 in the hospital sector of the British National Health Service. In contrast, the changes in the primary health care sector have gone largely undebated. This paper's contention is that these may turn out to be equally if not more important. The changes mean that general practice doctors are now subject to greater accountability than ever before through new management and finance systems, while new pay structures have shifted the emphasis of the service itself towards preventive health interventions. The new fundholding scheme, which allows some practices to apply to hold their own budgets and buy services for their patients, could alter the balance of power between the hospitals and general practice. In all, the emphasis of Government policy has been placed squarely on better pay for more and better work from general practice doctors while at the same time enabling patients to choose more freely where to register for primary health care. The changes in general practice could therefore achieve radical and permanent changes in the structure of the National Health Service and in the relationship between the State and the profession. [ABSTRACT FROM AUTHOR]

Focuses on asynchronous implementation of the ARM microprocessor based on Sutherland's Micropipelines. Rationale for the work, the organization for the chip and the characteristics of the prototype silicon; Asynchronous background; Micropipelines; Event driven pipelines; Architecture choice; Application of asynchronous approach to the design of a digital system; Asynchronous ARM of AMULET1; Evaluation of AMULET1; Results of the evaluation; Conclusions.

Abstract: Superconducting microwave microresonators are low temperature detectors compatible with large-scale multiplexed frequency domain readout. We aim to develop detector arrays for calorimetric measurement of the energy spectra of 163Ho EC decay ( ) for a direct measurement of the neutrino mass. We plan to investigate nitrides of high-Z materials, like TaN and HfN, that are appropriate for containing the energy of keV decay events, exploring the properties relevant to our detectors, such as quality factor, penetration depth and recombination time. [Copyright &y& Elsevier]

The kinetic inductance effect is strongly nonlinear with applied current in NbTiN, TiN and NbN thin films. This can be utilized to realize novel devices. We present results from transmission lines made with these materials, where DC (current) control is used to modulate the phase velocity thereby enabling on-chip spectrometers. Utility of such compact spectrometers is discussed, along with their natural connection with parametric amplifiers. [ABSTRACT FROM AUTHOR]

Superconducting On-chip Fourier Transform Spectrometers (SOFTS) are broadband, ultra-compact and electronic interferometers. SOFTS will enable kilo-pixel spectro-imaging focal planes, enhancing sub-millimeter astrophysics and cosmology. Particular applications include cluster astrophysics, cosmic microwave background (CMB) science, and line intensity mapping. This article details the development, design and bench-marking of radio frequency (RF) on-chip architecture of SOFTS for Ka and W-bands. [ABSTRACT FROM AUTHOR]

The galaxy evolution probe (GEP) is a concept for a probe-class space observatory to study the physical processes related to star formation over cosmic time. To do so, the mid- and far-infrared (IR) spectra of galaxies must be studied. These mid- and far-IR observations require large multi-frequency arrays, sensitive detectors. Our goal is to develop low NEP aluminum kinetic inductance detectors (KIDs) for wavelengths of 10–400 μ m for the GEP and a pathfinder long-duration balloon (GEP-B) that will perform precursor GEP science. KIDs for the lower wavelength range (10–100 μ m ) have not been previously implemented. We present an absorber design for KIDs sensitive to wavelengths of 10 μ m shown to have around 75–80% absorption efficiency through ANSYS HFSS (high-frequency structure simulator) simulations, challenges that come with optimizing our design to increase the wavelength range, initial tests on our design of fabricated 10 μ m KIDs, and theoretical NEP calculations. [ABSTRACT FROM AUTHOR]

An obituary for academic staff and civil engineer Geoff Eustace Blight is presented.

Discusses a study on the magnetic structure of KMnPO H[sub2]O. Structural parameters; Description of the crystal structure; Magnetic characterization.

A letter to the editor is presented in response to the article about the management of inflammatory root resorption using MTA obturation in the 2010 issue.

Introduction: An avulsed permanent tooth is one of the few true emergencies in dentistry. Children who suffer this injury require urgent dental care and prompt follow-up care. There is very limited evidence available regarding the provision of treatment for avulsion injuries in primary dental care.Objectives: To explore the experience of UK dentists in relation to the management of avulsed permanent teeth.Method: A self-completion questionnaire was designed and piloted. Questionnaires were sent to a random selection of one thousand GDPs with a stamped addressed return envelope. A second mailshot was sent to non-responders after eight weeks. Simple descriptive analysis was undertaken using Microsoft Excel. The results were compared with those from an earlier, similar study in Wales.Results: A total response rate of 61% was achieved. Just over 40% of responding dentists recalled replanting an avulsed permanent tooth in a child.Conclusions: Many dentists have limited or no experience of treating children with avulsed permanent teeth. Thirty-four percent of dentists have children with avulsion injuries under their care. Children with these traumatic injuries may benefit from shared care involving an interdisciplinary specialist team, in line with recommendations from the British Society of Paediatric Dentistry National Clinical Guidelines for Management of Avulsed Permanent Teeth in Children. [ABSTRACT FROM AUTHOR]

Superconducting microresonators have been successfully utilized as detection elements for a wide variety of applications. With multiplexing factors exceeding 1000 detectors per transmission line, they are the most scalable low-temperature detector technology demonstrated to date. For high-throughput applications, fewer detectors can be coupled to a single wire but utilize a larger per-detector bandwidth. For all existing designs, fluctuations in fabrication tolerances result in a non-uniform shift in resonance frequency and sensitivity, which ultimately limits the efficiency of bandwidth utilization. Here, we present the design, implementation, and initial characterization of a superconducting microresonator readout integrating two tunable inductances per detector. We demonstrate that these tuning elements provide independent control of both the detector frequency and sensitivity, allowing us to maximize the transmission line bandwidth utilization. Finally, we discuss the integration of these detectors in a multilayer fabrication stack for high-speed readout of the D-Wave quantum processor, highlighting the use of control and routing circuitry composed of single-flux-quantum loops to minimize the number of control wires at the lowest temperature stage. [ABSTRACT FROM AUTHOR]

Superconducting microresonators have been successfully utilized as detection elements for a wide variety of applications. With multiplexing factors exceeding 1000 detectors per transmission line, they are the most scalable low-temperature detector technology demonstrated to date. For high-throughput applications, fewer detectors can be coupled to a single wire but utilize a larger per-detector bandwidth. For all existing designs, fluctuations in fabrication tolerances result in a non-uniform shift in resonance frequency and sensitivity, which ultimately limits the efficiency of bandwidth utilization. Here, we present the design, implementation, and initial characterization of a superconducting microresonator readout integrating two tunable inductances per detector. We demonstrate that these tuning elements provide independent control of both the detector frequency and sensitivity, allowing us to maximize the transmission line bandwidth utilization. Finally, we discuss the integration of these detectors in a multilayer fabrication stack for high-speed readout of the D-Wave quantum processor, highlighting the use of control and routing circuitry composed of single-flux-quantum loops to minimize the number of control wires at the lowest temperature stage. [ABSTRACT FROM AUTHOR]

AC bolometer theory is built on the established matrix formalism for quantum calorimeters and bolometers. The bolometer is represented by a 3 $$\times $$ 3 matrix with complex valued parameters. The bolometer matrix is used to model the behavior of the devices including the response to signal and noise, feedback, pulse response times, stability, and bolometer impedance. The effects of a current dependent bolometer impedance are included. The matrix simplifies theoretical computations of AC devices, including demodulation and the interactions between signals at different frequencies. This theory is applied to measurements of bolometers, each consisting of a kinetic inductance device suspended on a silicon nitride membrane. These measurements and analysis facilitate the optimization of the design and performance of these novel AC bolometers. [ABSTRACT FROM AUTHOR]

This paper focuses on plain, stylistically unvaried pottery from three Late Neolithic sites from the Mondego Plateau, Portugal, and investigates ceramic production and exchange among small-scale prehistoric societies by means of thin-section petrography and chemical analysis (INAA). The results show that the majority of the pottery was made with widely available, granite-derived sedimentary clays, but petrographic differences between fabrics indicate collection at multiple locations within these deposits. Variation in chemical composition is consistent with site-specific sourcing areas, while comparison with data from earlier sites in the Mondego and surrounding mountains suggests that such sources were geographically restricted within the plateau. In contrast, the small percentage of vessels produced with residual clays of metamorphic and intermediate igneous origin, which outcrop over 10 km and 30 km from the archaeological sites, demonstrates that plain pottery did circulate during the Neolithic beyond the funerary sphere. This is the product of the routines of mobility and social networks of Neolithic groups across the wider landscape, which involved the exchange of 'mundane' vessels. Finally, the study demonstrates that micro-regional provenance studies can provide significant insights into prehistoric social landscapes if the data are interrogated beyond simplistic classifications of local and non-local. [ABSTRACT FROM AUTHOR]

We are developing of arrays of membrane isolated resonator-bolometers, each with a kinetic inductance device (KID) to measure the temperature of the membrane. The KIDs are fabricated out of the high temperature superconductor YBCO to allow operation at relatively high temperatures. The bolometers are designed to offer higher sensitivity than sensors operating at 300 K, but they require less expensive and lighter weight cooling than even more sensitive conventional superconducting detectors operating at lower temperatures. The bolometer arrays are applicable as focal planes in infrared imaging spectrometers, such as for planetary science missions or earth observing satellites. We describe the devices and present measurements of their sensitivity. [ABSTRACT FROM AUTHOR]

Horses that had been trimmed and shod by apprentice farriers were sourced from the Royal School of Military Engineering, Melton Mowbray (37 horses) and from the Household Cavalry, Knightsbridge (54 horses). The lateral and medial hoof wall angles of both forelimbs were measured using a Ruidoso hoof gauge by the same operator. The difference between the lateral and medial hoof wall angles for each horse was calculated and the results were compared between right-handed and left-handed farriers using the Mann-Whitney U test (P<0.05). There was a significant difference in the mediolateral hoof balance obtained between right-handed and left-handed farriers for each forelimb (P<0.001). Right-handed farriers were shown to create an imbalance in 47 per cent of left forelimbs and 46 per cent of right forelimbs assessed, while left-handed farriers created an imbalance in 41 per cent of left forelimbs and 71 per cent of right forelimbs. The tendency was for right-handed farriers to over-trim the medial (inner) aspect of the left forelimb and the lateral (outer) aspect of the right forelimb; the reverse was demonstrated for left-handed farriers. Performing a risk ratio confirmed these findings. [ABSTRACT FROM PUBLISHER]

Context Hoof testers are commonly used in equine practice. In this study, we determined the intraoperator and interoperator reliability of force application with hoof testers for different groups: experienced veterinarians, novices and farriers. For this purpose, we have developed and validated an instrumented hoof tester. Forces varied significantly between the different regions of the foot for experienced operators applying the highest forces to the heels, then the frog, then the toe, and the lowest forces to the quarters. Novices applied significantly more force to the toe versus the frog. Intraoperator reliability varied significantly between regions and operators. Novices had the narrowest width of limits of agreement for the frog and heel, but the widest for the toe and the quarters, whereas farriers had the narrowest width of agreement for the toe and quarter. Force application differed significantly between groups for the frog and heel regions, but not the toe and quarters. Veterinarians applied higher forces to the frog compared with farriers and novices, and higher forces to the heel compared with novices. This study showed that hoof tester forces vary widely within and between operators, and standardisation of hoof tester use is needed to make this diagnostic test more reliable. [ABSTRACT FROM AUTHOR]