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1. A Transcriptomic Comparative Study of Cranial Vasculature

Author

Zhang, Jianing, Ryu, Jee-Yeon, Tirado, Selena-Rae, Dickinson, Lawrence D., Abosch, Aviva, Aziz-Sultan, M. Ali, Boulos, Alan S., Barrow, Daniel L., Batjer, H. Hunt, Binyamin, Tamar R., Blackburn, Spiros L., Chang, Edward F., Chen, P. Roc, Colby, Geoffrey P., Cosgrove, G. Rees, David, Carlos A., Day, Arthur L., Folkerth, Rebecca D., Frerichs, Kai U., Howard, Brian M., Jahromi, Behnam R., Niemela, Mika, Ojemann, Steven G., Patel, Nirav J., Richardson, R. Mark, Shi, Xiangen, Valle-Giler, Edison P., Wang, Anthony C., Welch, Babu G., Williams, Ziv, Zusman, Edie E., Weiss, Scott T., and Du, Rose

Published
2024
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2. Somatic Variants in SVIL in Cerebral Aneurysms

Author

Lai, Pui Man Rosalind, Ryu, Jee-Yeon, Park, Sang-Cheol, Gross, Bradley A, Dickinson, Lawrence D, Dagen, Sarajune, Aziz-Sultan, Mohammad Ali, Boulos, Alan S, Barrow, Daniel L, Batjer, H Hunt, Blackburn, Spiros, Chang, Edward F, Chen, P Roc, Colby, Geoffrey P, Cosgrove, Garth Rees, David, Carlos A, Day, Arthur L, Frerichs, Kai U, Niemela, Mika, Ojemann, Steven G, Patel, Nirav J, Shi, Xiangen, Valle-Giler, Edison P, Wang, Anthony C, Welch, Babu G, Zusman, Edie E, Weiss, Scott T, and Du, Rose

Subjects
Biochemistry and Cell Biology, Bioinformatics and Computational Biology, Genetics, Biological Sciences, Brain Disorders, Biotechnology, Cardiovascular, Stroke, Neurosciences, Clinical Research, 2.1 Biological and endogenous factors, Aetiology, Clinical sciences
Abstract

Background and objectivesWhile somatic mutations have been well-studied in cancer, their roles in other complex traits are much less understood. Our goal is to identify somatic variants that may contribute to the formation of saccular cerebral aneurysms.MethodsWe performed whole-exome sequencing on aneurysm tissues and paired peripheral blood. RNA sequencing and the CRISPR/Cas9 system were then used to perform functional validation of our results.ResultsSomatic variants involved in supervillin (SVIL) or its regulation were found in 17% of aneurysm tissues. In the presence of a mutation in the SVIL gene, the expression level of SVIL was downregulated in the aneurysm tissue compared with normal control vessels. Downstream signaling pathways that were induced by knockdown of SVIL via the CRISPR/Cas9 system in vascular smooth muscle cells (vSMCs) were determined by evaluating changes in gene expression and protein kinase phosphorylation. We found that SVIL regulated the phenotypic modulation of vSMCs to the synthetic phenotype via Krüppel-like factor 4 and platelet-derived growth factor and affected cell migration of vSMCs via the RhoA/ROCK pathway.DiscussionWe propose that somatic variants form a novel mechanism for the development of cerebral aneurysms. Specifically, somatic variants in SVIL result in the phenotypic modulation of vSMCs, which increases the susceptibility to aneurysm formation. This finding suggests a new avenue for the therapeutic intervention and prevention of cerebral aneurysms.

Published
2022

8. Contributors

Author

Adams, Harold P., primary, Adeoye, Opeolu, additional, Albers, Gregory W., additional, Alexandrov, Andrei V., additional, Amin-Hanjani, Sepideh, additional, An, Hongyu, additional, Anderson, Craig S., additional, Anrather, Josef, additional, Aparicio, Hugo J., additional, Arai, Ken, additional, Aronowski, Jaroslaw, additional, Atchaneeyasakul, Kunakorn, additional, Audebert, Heinrich, additional, Auer, Roland N., additional, Awad, Issam A., additional, Ay, Hakan, additional, Baltan, Selva, additional, Balu, Ramani, additional, Behbahani, Mandana, additional, Benavente, Oscar R., additional, Bershad, Eric M., additional, Berthaud, Jimmy V., additional, Blackburn, Spiros L., additional, Bonati, Leo H., additional, Bösel, Julian, additional, Bousser, Marie Germaine, additional, Broderick, Joseph P., additional, Brown, Martin M., additional, Brown, Wendy, additional, Brust, John C.M., additional, Bushnell, Cheryl, additional, Canhão, Patrícia, additional, Caplan, Louis R., additional, Carrión-Penagos, Julián, additional, Castellanos, Mar, additional, Caunca, Michelle R., additional, Chabriat, Hugues, additional, Chamorro, Angel, additional, Chen, Jieli, additional, Chen, Jun, additional, Chopp, Michael, additional, Christorforids, Greg, additional, Connolly, E. Sander, additional, Cramer, Steven C., additional, Cucchiara, Brett L., additional, Czap, Alexandra L., additional, Dannenbaum, Mark J., additional, Davis, Patricia H., additional, Dawson, Ted M., additional, Dawson, Valina L., additional, Day, Arthur L., additional, De Silva, T. Michael, additional, de Sousa, Diana Aguiar, additional, Del Brutto, Victor J., additional, del Zoppo, Gregory J., additional, Derdeyn, Colin P., additional, Di Tullio, Marco R., additional, Diener, Hans Christoph, additional, Diringer, Michael N., additional, Dobkin, Bruce H., additional, Dzialowski, Imanuel, additional, Elkind, Mitchell S.V., additional, Elm, Jordan, additional, Feigin, Valery L., additional, Ferro, José Manuel, additional, Field, Thalia S., additional, Fischer, Marlene, additional, Fornage, Myriam, additional, Furie, Karen L., additional, Garcia-Bonilla, Lidia, additional, Giannotta, Steven L., additional, Gobin, Y. Pierre, additional, Goldberg, Mark P., additional, Goldstein, Larry B., additional, Gonzales, Nicole R., additional, Greer, David M., additional, Grotta, James C., additional, Guo, Ruiming, additional, Gutierrez, Jose, additional, Harmel, Peter, additional, Howard, George, additional, Howard, Virginia J., additional, Hwang, Jee-Yeon, additional, Iadecola, Costantino, additional, Jahan, Reza, additional, Jickling, Glen C., additional, Joutel, Anne, additional, Kasner, Scott E., additional, Katan, Mira, additional, Kellner, Christopher P., additional, Khan, Muhib, additional, Kidwell, Chelsea S., additional, Kim, Helen, additional, Kim, Jong S., additional, Kircher, Charles E., additional, Krings, Timo, additional, Krishnamurthi, Rita V., additional, Kurth, Tobias, additional, Lansberg, Maarten G., additional, Levy, Elad I., additional, Liebeskind, David S., additional, Liew, Sook-Lei, additional, Lin, David J., additional, Lisle, Benjamin, additional, Lo, Eng H., additional, Lyden, Patrick D., additional, Maki, Takakuni, additional, Maragkos, Georgios A., additional, Marosfoi, Miklos, additional, McCullough, Louise D., additional, Meckler, Jason M., additional, Meschia, James Frederick, additional, Messé, Steven R., additional, Mocco, J, additional, Mokin, Maxim, additional, Mooney, Michael A., additional, Morgenstern, Lewis B., additional, Moskowitz, Michael A., additional, Mullen, Michael T., additional, Nägel, Steffen, additional, Nedergaard, Maiken, additional, Neira, Justin A., additional, Newman, Sarah, additional, Nicholson, Patrick J., additional, Norrving, Bo, additional, O’Donnell, Martin, additional, Ofengeim, Dimitry, additional, Ogata, Jun, additional, Ogilvy, Christopher S., additional, Orrù, Emanuele, additional, Ortega-Gutiérrez, Santiago, additional, Padrick, Matthew Maximillian, additional, Parsha, Kaushik, additional, Parsons, Mark, additional, Patel, Neil V., additional, Patel, Virendra I., additional, Pawlikowska, Ludmila, additional, Pérez, Adriana, additional, Perez-Pinzon, Miguel A., additional, Picard, John M., additional, Polster, Sean P., additional, Powers, William J., additional, Puetz, Volker, additional, Putaala, Jukka, additional, Rabinovich, Margarita, additional, Ransom, Bruce R., additional, Roa, Jorge A., additional, Rosenberg, Gary A., additional, Rossitto, Christina P., additional, Rundek, Tatjana, additional, Russin, Jonathan J., additional, Sacco, Ralph L., additional, Safouris, Apostolos, additional, Samaniego, Edgar A., additional, Sansing, Lauren H., additional, Satani, Nikunj, additional, Sattenberg, Ronald J., additional, Saver, Jeffrey L., additional, Savitz, Sean I., additional, Schmidt, Christian, additional, Seshadri, Sudha, additional, Sharma, Vijay K., additional, Sharp, Frank R., additional, Sheth, Kevin N., additional, Siddiqi, Omar K., additional, Singhal, Aneesh B., additional, Sobey, Christopher G., additional, Sommer, Clemens J., additional, Spetzler, Robert F., additional, Stapleton, Christopher J., additional, Strickland, Ben A., additional, Su, Hua, additional, Suarez, José I., additional, Takayama, Hiroo, additional, Tarsia, Joseph, additional, Tatlisumak, Turgut, additional, Thomas, Ajith J., additional, Thompson, John W., additional, Tsivgoulis, Georgios, additional, Tournier-Lasserve, Elizabeth, additional, Vidal, Gabriel, additional, Wakhloo, Ajay K., additional, Weksler, Babette B., additional, Willey, Joshua Z., additional, Wintermark, Max, additional, Wong, Lawrence K.S., additional, Xi, Guohua, additional, Xu, Jinchong, additional, Yaghi, Shadi, additional, Yamaguchi, Takenori, additional, Yang, Tuo, additional, Yasaka, Masahiro, additional, Zahuranec, Darin B., additional, Zhang, Feng, additional, Zhang, John H., additional, Zheng, Zhitong, additional, Zukin, R. Suzanne, additional, and Zweifler, Richard M., additional

Published
2022
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14. BRAF/MEK Dual Inhibitors Therapy in Progressive and Anaplastic Pleomorphic Xanthoastrocytoma: Case Series and Literature Review

Author

Kata, Karolina, primary, Rodriguez-Quintero, Juan C., additional, Arevalo, Octavio D., additional, Zhang, Jackie J., additional, Bhattacharjee, Meenakshi Bidwai, additional, Ware, Cornelius, additional, Dono, Antonio, additional, Riascos-Castaneda, Roy, additional, Tandon, Nitin, additional, Blanco, Angel, additional, Esquenazi, Yoshua, additional, Ballester, Leomar Y., additional, Amsbaugh, Mark, additional, Day, Arthur L., additional, and Zhu, Jay-Jiguang, additional

Published
2022
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18. Primary balloon angioplasty of venous Sinus stenosis in idiopathic intracranial hypertension.

Author

Carlos Martinez-Gutierrez, Juan, Kole, Matthew J, Lopez-Rivera, Victor, Inam, Mehmet Enes, Tang, Rosa, Al-Zubidi, Nagham, Adesina, Ore-Ofeoluwatomi, Lekka, Elvira, Engstrom, Allison C., Sheth, Sunil, Pedroza, Claudia, Day, Arthur L., and Chen, Peng Roc

Subjects
INTRACRANIAL hypertension, ENDOVASCULAR surgery, VENOUS pressure, STENOSIS, SUBDURAL hematoma
Abstract

Background: Venous sinus stenosis (VSS) stenting has emerged as an effective treatment for patients with Idiopathic Intracranial Hypertension (IIH). However, stenting carries risk of in-stent stenosis/thrombosis and cumulative bleeding risk from long-term dual antiplatelet (DAPT) use. Thus, we investigated the potential safety and efficacy of primary balloon angioplasty as an alternative to stenting in IIH. Methods: A prospectively maintained single-center registry of IIH patients undergoing endovascular procedures was queried. Inclusion criteria included patients with confirmed IIH and angiographically demonstrable VSS who underwent interventions from 2012- 2021. Patients were dichotomized into primary balloon angioplasty (Group A) and primary stenting (Group S), comparing clinical outcomes using bivariate analyses. Results: 62 patients were included with median age of 33 [IQR 26-37], 74% females. Group A (9/62) and Group S (53/62) had similar baseline characteristics. Papilledema improvement was higher in Group S at 6 weeks and 6 months (44 vs. 93, p = 0.002 and 44 vs. 92%, p = 0.004), with similar improvements across all symptoms. Group S had higher mean post-procedure venous pressure gradient change (8 vs. 3 mmHg, p = 0.02) and a lower CSF opening pressure at 6 months (23 vs. 36 cmH2O, p < 0.001). VPS rescue rate was higher in Group A (44 vs. 2%, p = 0.001). There was only one procedural complications; a subdural hematoma in Group A. Conclusions: Primary VSS balloon angioplasty provides a marginal and short-lived improvement of IIH symptoms compared to stenting. These findings suggest a cautious and limited role for short-term rescue angioplasty in poor shunting and stenting candidates with refractory IIH. [ABSTRACT FROM AUTHOR]

Published
2023
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21. Primary balloon angioplasty of venous Sinus stenosis in idiopathic intracranial hypertension

Author

Carlos Martinez-Gutierrez, Juan, primary, Kole, Matthew J, additional, Lopez-Rivera, Victor, additional, Inam, Mehmet Enes, additional, Tang, Rosa, additional, Al-Zubidi, Nagham, additional, Adesina, Ore-Ofeoluwatomi, additional, Lekka, Elvira, additional, Engstrom, Allison C., additional, Sheth, Sunil, additional, Pedroza, Claudia, additional, Day, Arthur L., additional, and Chen, Peng Roc, additional

Published
2022
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22. List of Contributors

Author

Adams, Harold P., primary, El Ahmadieh, Tarek Y., additional, Albers, Gregory W., additional, Alexandrov, Andrei V., additional, Anrather, Josef, additional, Arai, Ken, additional, Aronowski, Jaroslaw (Jarek), additional, Auer, Roland N., additional, Awad, Issam A., additional, Ay, Hakan, additional, Baltan, Selva, additional, Batjer, Hunt H., additional, Benavente, Oscar R., additional, Bendok, Bernard R., additional, Bershad, Eric M., additional, Bonati, Leo H., additional, Bookland, Markus J., additional, Bousser, Marie-Germaine, additional, Braca, John A., additional, Broderick, Joseph P., additional, Brown, Martin M., additional, Brown, Wendy E., additional, Brust, John C.M., additional, Bushnell, Cheryl, additional, Bösel, Julian, additional, Canhão, Patrícia, additional, Caplan, Louis R., additional, Castellanos, Mar, additional, Chamorro, Angel, additional, Chandler, James P., additional, Chen, Jun, additional, Chopp, Michael, additional, Chrissobolis, Sophocles, additional, Chabriat, Hugues, additional, Cramer, Steven C., additional, Cucchiara, Brett L., additional, Dannenbaum, Mark J., additional, Davis, Patricia H., additional, Dawson, Ted M., additional, Dawson, Valina L., additional, Day, Arthur L., additional, del Zoppo, Gregory J., additional, Diener, Hans-Christoph, additional, Di Tullio, Marco R., additional, Dobkin, Bruce H., additional, Dzialowski, Imanuel, additional, Economos, Alexis, additional, Eddleman, Christopher S., additional, Elkind, Mitchell S.V., additional, Feigin, Valery L., additional, Ferro, José M., additional, Findlay, J. Max, additional, Furie, Karen L., additional, Fusco, Matthew R., additional, Field, Thalia S., additional, Geibprasert, Sasikhan, additional, Gensic, Anna P., additional, Gobin, Y. Pierre, additional, Goldberg, Mark P., additional, Goldstein, Larry B., additional, Gonzales, Nicole R., additional, Gounis, Matthew J., additional, Greenberg, Steven M., additional, Gregson, Barbara A., additional, Grotta, James C., additional, Gutierrez, Jose, additional, Hacke, Werner, additional, Hallenbeck, John M., additional, Haršány, Michal, additional, Heiferman, Daniel M., additional, Homma, Shunichi, additional, Howard, George, additional, Howard, Virginia J., additional, Hwang, Jee-Yeon, additional, Iadecola, Costantino, additional, Jahan, Reza, additional, Joutel, Anne, additional, Jüttler, Eric, additional, Kase, Carlos S., additional, Kasner, Scott E., additional, Katan, Mira, additional, Khader Eliyas, Javed, additional, Khan, Muhib, additional, Kim, Helen, additional, Kidwell, Chelsea S., additional, Kim, Jong S., additional, Krings, Timo, additional, Krishnamurthi, Rita, additional, Kurth, Tobias, additional, Lamy, Catherine, additional, Lansberg, Maarten G., additional, Levy, Elad I., additional, Liebeskind, David S., additional, Lo, Eng H., additional, Loftus, Christopher M., additional, Lyden, Patrick D., additional, Mas, Jean-Louis, additional, Massari, Francesco, additional, Meckler, Jason M., additional, Mendelow, A. David, additional, Meschia, James F., additional, Messé, Steven R., additional, Mitchel, Patrick, additional, Morgenstern, Lewis B., additional, Mokin, Maxim, additional, Moskowitz, Michael A., additional, Mullen, Michael T., additional, Nedergaard, Maiken, additional, Neugebauer, Hermann, additional, Newell, David W., additional, Norrving, Bo, additional, O'Donnell, Martin, additional, Ofengeim, Dimitry, additional, Ogata, Jun, additional, Ogilvy, Christopher S., additional, Pancioli, Arthur M., additional, Parsha, Kaushik, additional, Parsons, Mark W., additional, Pawlikowska, Ludmila, additional, Pérez, Adriana, additional, Perez-Pinzon, Miguel A., additional, Powers, William J., additional, Puetz, Volker, additional, Puri, Ajit S., additional, Ransom, Bruce R., additional, Roine, Risto O., additional, Rundek, Tatjana, additional, Russin, Jonathan J., additional, Sacco, Ralph L., additional, Spetzler, Robert F., additional, Sattenberg, Ronald J., additional, Saver, Jeffrey L., additional, Savitz, Sean I., additional, Schönenberger, Silvia, additional, Seshadri, Sudha, additional, Sharma, Vijay K., additional, Shi, Yejie, additional, Shoamanesh, Ashkan, additional, Silverboard, Gerald, additional, Singhal, Aneesh B., additional, Sobey, Christopher G., additional, Stapf, Christian, additional, Su, Hua, additional, Suarez, Jose I., additional, Sykora, Marek, additional, Tatlisumak, Turgut, additional, El Tecle, Najib, additional, terBrugge, Karel G., additional, Thompson, John W., additional, Tilley, Barbara C., additional, Tournier-Lasserve, Elisabeth, additional, Tsivgoulis, Georgios, additional, Vilela, Marcelo D., additional, von Kummer, Rüdiger, additional, Wakhloo, Ajay K., additional, Wagner, Kenneth R., additional, Warach, Steven, additional, Weksler, Babette B., additional, Werring, David, additional, Willey, Joshua Z., additional, Wintermark, Max, additional, Wolf, Philip A., additional, Wong, Lawrence K.S., additional, Woo, Daniel, additional, Wright, Clinton, additional, Xi, Guohua, additional, Yamaguchi, Takenori, additional, Yasaka, Masahiro, additional, Young, William L., additional, Zammar, Samer G., additional, Zahuranec, Darin B., additional, Zhang, Feng, additional, Zhang, Haiyue, additional, Zhang, John H., additional, Zhang, Zheng Gang, additional, Zukin, R. Suzzane, additional, and Zweifler, Richard M., additional

Published
2016
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26. Abstract 42: The Effect Of Anesthesia On Thrombectomy Outcomes Is Modified By Collateral Flow: Pooled Patient Level Analysis From EXTEND-IA, EXTEND-IA TNK Part I And II, And SELECT

Author

Sarraj, Amrou, primary, Albers, Gregory, additional, Hassan, Ameer, additional, Abraham, Michael G, additional, Blackburn, Spiros, additional, Hussain, Muhammad, additional, Tekle, Wondwossen, additional, Ortega-Gutierrez, Santiago, additional, Aghaebrahim, Amin N, additional, Haussen, Diogo C, additional, Toth, Gabor, additional, Budzik, Ronald, additional, Pujara, Deep K, additional, Hicks, William J, additional, Vora, Nirav, additional, Edgell, Randall C, additional, Slavin, Sabreena, additional, Lechtenberg, Colleen G, additional, Maali, Laith N, additional, Qureshi, Abid Y, additional, Rosterman, Lee, additional, Aertker, Benjamin, additional, Abdulrazzak, Mohammad A, additional, Mir, Osman, additional, Parsha, Kaushik N, additional, Reddy, Sujan S, additional, Alenzi, Bader, additional, Cai, Chunyan, additional, Almaghrabi, Tareq S, additional, Shaker, Faris, additional, Kamal, Haris, additional, Arora, Ashish, additional, Yassi, Nawaf, additional, Sharma, Gagan J, additional, Kleinig, Timothy J, additional, Shah, Darshan, additional, Wu, Teddy Y, additional, Martin-schild, Sheryl B, additional, Day, Arthur L, additional, sitton, clark W, additional, Mitchell, Peter J, additional, Gupta, Rishi, additional, Lansberg, Maarten G, additional, Nogueira, Raul G, additional, Donnan, Geoffrey A, additional, Davis, Stephen, additional, Grotta, James C, additional, and Campbell, Bruce C, additional

Published
2022
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27. Neurosurgery residency and fellowship education in the United States: 2 decades of system development by the One Neurosurgery Summit organizations

Author

Selden, Nathan R., primary, Barbaro, Nicholas M., additional, Barrow, Daniel L., additional, Batjer, H. Hunt, additional, Branch, Charles L., additional, Burchiel, Kim J., additional, Byrne, Richard W., additional, Dacey, Ralph G., additional, Day, Arthur L., additional, Dempsey, Robert J., additional, Derstine, Pamela, additional, Friedman, Allan H., additional, Giannotta, Steven L., additional, Grady, M. Sean, additional, Harsh, Griffith R., additional, Harbaugh, Robert E., additional, Mapstone, Timothy B., additional, Muraszko, Karin M., additional, Origitano, Thomas C., additional, Orrico, Katie O., additional, Popp, A. John, additional, Sagher, Oren, additional, Selman, Warren R., additional, and Zipfel, Gregg J., additional

Published
2022
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30. INNV-06. BRAF AND MEK DUAL INHIBITORS THERAPY IN RECURRENT OR ANAPLASTIC PLEOMORPHIC XANTHOASTROCYTOMA (PXA)

Author

Kata, Karolina, primary, Quintero, Juan Carlos Rodriguez, additional, Arevalo-Espejo, Octavio, additional, Bhattacharjee, Meenakshi Bidwai, additional, Ware, Cornelius, additional, Dono, Antonio, additional, Riascos-Castaneda, Roy, additional, Tandon, Nitin, additional, Blanco, Angel, additional, Esquenazi, Yoshua, additional, Ballester, Leomar Y, additional, Amsbaugh, Mark, additional, Day, Arthur L, additional, and Zhu, Jay-Jiguang, additional

Published
2021
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37. Direct to Angiography vs Repeated Imaging Approaches in Transferred Patients Undergoing Endovascular Thrombectomy

Author

Sarraj, Amrou, primary, Goyal, Nitin, additional, Chen, Michael, additional, Grotta, James C., additional, Blackburn, Spiros, additional, Requena, Manuel, additional, Kamal, Haris, additional, Abraham, Michael G., additional, Elijovich, Lucas, additional, Dannenbaum, Mark, additional, Mir, Osman, additional, Tekle, Wondwossen G., additional, Pujara, Deep, additional, Shaker, Faris, additional, Cai, Chunyan, additional, Maali, Laith, additional, Radaideh, Yazan, additional, Reddy, Sujan Teegala, additional, Parsha, Kaushik Niranjan, additional, Alenzi, Bader, additional, Abdulrazzak, Mohammad Ammar, additional, Greco, Jonathan, additional, Hoit, Daniel, additional, Martin-Schild, Sheryl B., additional, Song, Sarah, additional, Sitton, Clark, additional, Tsivgoulis, Georgios K., additional, Alexandrov, Andrei V., additional, Arthur, Adam S., additional, Day, Arthur L., additional, Hassan, Ameer E., additional, and Ribo, Marc, additional

Published
2021
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39. Endovascular Thrombectomy Outcomes in Transferred Octogenarians: A Multicenter Pooled Analysis

Author

Greco, Jonathan Chen, Michael Hassan, Ameer E. Goyal, Nitin and Kamal, Haris Blackburn, Spiros Abraham, Michael G. Day, Arthur L. Sitton, Clark Requena, Manuel Grotta, James C. and Elijovich, Lucas Dannenbaum, Mark J. Tekle, Wondwossen Hoit, Daniel Pujara, Deep Shaker, Faris Reddy, Sujan S. Azher, I, Aidan Abdulrazzak, Mohammad Ammar Mir, Osman Parsha, Kaushik N. Martin-schild, Sheryl Tsivgoulis, Georgios K. and Alexandrov, V, Andrei Ribo, Marc Sarraj, Amrou

Published
2021

40. Direct to Angio in Transferred Patients is Associated With Faster Reperfusion and Higher Functional Independence Rates Both During Regular and On-Call Hours: A Multi Center Cohort

Author

Sarraj, Amrou Goyal, Nitin Chen, Michael Blackburn, Spiros and Requena, Manuel Kamal, Haris Grotta, James C. Abraham, Michael G. Elijovich, Lucas Mir, Osman Tekle, Wondwossen G. and Pujara, Deep Shaker, Faris Reddy, Sujan T. Parsha, Kaushik N. Alenzi, Bader Hoit, Daniel Martin-schild, Sheryl B. Song, Sarah Sitton, Clark Tsivgoulis, Georgios K. and Alexandrov, V, Andrei Arthur, Adam S. Day, Arthur L. Hassan, Ameer E. Ribo, Marc

Published
2021

41. Direct to Angiography vs Repeated Imaging Approaches in Transferred Patients Undergoing Endovascular Thrombectomy

Author

Sarraj, Amrou Goyal, Nitin Chen, Michael Grotta, James C. and Blackburn, Spiros Requena, Manuel Kamal, Haris Abraham, Michael G. Elijovich, Lucas Dannenbaum, Mark Mir, Osman and Tekle, Wondwossen G. Pujara, Deep Shaker, Faris Cai, Chunyan and Maali, Laith Radaideh, Yazan Reddy, Sujan Teegala and Parsha, Kaushik Niranjan Alenzi, Bader Abdulrazzak, Mohammad Ammar Greco, Jonathan Hoit, Daniel Martin-Schild, Sheryl B. and Song, Sarah Sitton, Clark Tsivgoulis, Georgios K. and Alexandrov, Andrei V. Arthur, Adam S. Day, Arthur L. Hassan, Ameer E. Ribo, Marc

Abstract

IMPORTANCE A direct to angiography (DTA) treatment paradigm without repeated imaging for transferred patients with large vessel occlusion (LVO) may reduce time to endovascular thrombectomy (EVT). Whether DTA is safe and associated with better outcomes in the late (>6 hours) window is unknown. Also, DTA feasibility and effectiveness in reducing time to EVT during on-call vs regular-work hours and the association of interfacility transfer times with DTA outcomes have not been established. OBJECTIVE To evaluate the functional and safety outcomes of DTA vs repeated imaging in the different treatment windows and on-call hours vs regular hours. DESIGN, SETTING, AND PARTICIPANTS This pooled retrospective cohort study at 6 US and European comprehensive stroke centers enrolled adults (aged >= 18 years) with anterior circulation LVO (internal cerebral artery or middle cerebral artery subdivisions M1/M2) and transferred for EVT within 24 hours of the last-known-well time from January 1, 2014, to February 29, 2020. EXPOSURES Repeated imaging (computed tomography with or without computed tomographic angiography or computed tomography perfusion) before EVT vs DTA. MAIN OUTCOMES AND MEASURES Functional independence (90-day modified Rankin Scale score, 0-2) was the primary outcome. Symptomatic intracerebral hemorrhage, mortality, and time metrics were also compared between the DTA and repeated imaging groups. RESULTS A total of 1140 patients with LVO received EVT after transfer, including 327 (28.7%) in the DTA group and 813 (71.3%) in the repeated imaging group. The median age was 69 (interquartile range [IQR], 59-78) years; 529 were female (46.4%) and 609 (53.4%) were male. Patients undergoing DTA had greater use of intravenous alteplase (200 of 327 [61.2%] vs 412 of 808 [51.0%]; P = .002), but otherwise groups were similar. Median time from EVT center arrival to groin puncture was faster with DTA (34 [IQR, 20-62] vs 60 [IQR, 37-95] minutes; P < .001), overall and in both regular and on-call hours. Three-month functional independence was higher with DTA overall (164 of 312 [52.6%] vs 282 of 763 [37.0%]; adjusted odds ratio [aOR], 1.85 [95% CI, 1.33-2.57]; P < .001) and during regular (77 of 143 [53.8%] vs 118 of 292 [40.4%]; P = .008) and on-call (87 of 169 [51.5%] vs 164 of 471 [34.8%]; P < .001) hours. The results did not vary by time window (0-6 vs >6 to 24 hours; P = .88 for interaction). Three-month mortality was lower with DTA (53 of 312 [17.0%] vs 186 of 763 [24.4%]; P = .008). A 10-minute increase in EVT-center arrival to groin puncture in the repeated imaging group correlated with 5% reduction in the functional independence odds (aOR, 0.95 [95% CI, 0.91-0.99]; P = .01). The rates of modified Rankin Scale score of 0 to 2 decreased with interfacility transfer times of greater than 3 hours in the DTA group (96 of 161 [59.6%] vs 15 of 42 [35.7%]; P = .006), but not in the repeated imaging group (75 of 208 [36.1%] vs 71 of 192 [37.0%]; P = .85). CONCLUSIONS AND RELEVANCE The DTA approach may be associated with faster treatment and better functional outcomes during all hours and treatment windows, and repeated imaging may be reasonable with prolonged transfer times. Optimal EVT workflow in transfers may be associated with faster, safe reperfusion with improved outcomes.

Published
2021

43. Abstract P463: Direct to Angio in Transferred Patients is Associated With Faster Reperfusion and Higher Functional Independence Rates Both During Regular and On-Call Hours: A Multi Center Cohort

Author

Sarraj, Amrou, primary, Goyal, Nitin, additional, Chen, Michael, additional, Blackburn, Spiros, additional, Requena, Manuel, additional, Kamal, Haris, additional, Grotta, James C, additional, Abraham, Michael G, additional, Elijovich, Lucas, additional, Mir, Osman, additional, Tekle, Wondwossen G, additional, Pujara, Deep, additional, Shaker, Faris, additional, Reddy, Sujan T, additional, Parsha, Kaushik N, additional, Alenzi, Bader, additional, Hoit, Daniel, additional, Martin-schild, Sheryl B, additional, Song, Sarah, additional, Sitton, Clark, additional, Tsivgoulis, Georgios K, additional, Alexandrov, Andrei V, additional, Arthur, Adam S, additional, Day, Arthur L, additional, Hassan, Ameer E, additional, and Ribo, Marc, additional

Published
2021
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44. Abstract P473: Perfusion Imaging Identifies Patients With Mild Deficits Due to Large Vessel Occlusion Who May Benefit From Endovascular Thrombectomy: A Pooled International Cohort Study

Author

Sarraj, Amrou, primary, Ribo, Marc, additional, Blasco, Jordi, additional, Perez de la Ossa, Natalia, additional, Chen, Michael, additional, Hassan, Ameer E, additional, Wu, Teddy Y, additional, Cordato, Dennis, additional, Kleinig, Timothy J, additional, Schaafsma, Joanna D, additional, Blackburn, Spiros, additional, Abraham, Michael G, additional, Gibson, Daniel, additional, Wallace, Adam, additional, Pujara, Deep, additional, Shaker, Faris, additional, Moreno Negrete, Javier, additional, Beharry, James, additional, Cappelen-Smith, Cecilia, additional, Rodríguez-Esparragoza, Luis, additional, Olivé Gadea, Marta, additional, Requena, Manuel, additional, Pereira, Vitor, additional, Day, Arthur L, additional, Sitton, Clark, additional, Martin-schild, Sheryl B, additional, Song, Sarah, additional, Mitchell, Peter J, additional, Parsons, Mark, additional, Grotta, James C, additional, and Albers, Greg, additional

Published
2021
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45. Integrated Stroke System Model Expands Availability of Endovascular Therapy While Maintaining Quality Outcomes

Author

Lopez-Rivera, Victor, primary, Salazar-Marioni, Sergio, additional, Abdelkhaleq, Rania, additional, Savitz, Sean I., additional, Czap, Alexandra L., additional, Alderazi, Yazan J., additional, Chen, Peng R., additional, Grotta, James C., additional, Blackburn, Spiros L., additional, Jones, Wesley, additional, Spiegel, Gary, additional, Dannenbaum, Mark J., additional, Wu, Tzu-Ching, additional, Cochran, Joseph, additional, Kim, Dong H., additional, Day, Arthur L., additional, Farquhar, Grace, additional, McCullough, Louise D., additional, and Sheth, Sunil A., additional

Published
2021
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46. Abstract P525: Endovascular Thrombectomy Outcomes in Transferred Octogenarians: A Multicenter Pooled Analysis

Author

Greco, Jonathan, primary, Chen, Michael, additional, Hassan, Ameer E, additional, Goyal, Nitin, additional, Kamal, Haris, additional, Blackburn, Spiros, additional, Abraham, Michael G, additional, Day, Arthur L, additional, sitton, clark, additional, Requena, Manuel, additional, Grotta, James c, additional, Elijovich, Lucas, additional, Dannenbaum, Mark J, additional, Tekle, Wondwossen, additional, Hoit, Daniel, additional, Pujara, Deep, additional, Shaker, Faris, additional, Reddy, Sujan S, additional, Azher, Aidan I, additional, Abdulrazzak, Mohammad Ammar, additional, Mir, Osman, additional, Parsha, Kaushik N, additional, Martin-schild, Sheryl, additional, Tsivgoulis, Georgios K, additional, Alexandrov, Andrei V, additional, Ribo, Marc, additional, and Sarraj, Amrou, additional

Published
2021
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49. Contributors

Author

Acosta, Frank L., primary, Adelson, P. David, additional, Adler, ., John R., additional, Aghayev, Kamran V., additional, Aghi, Manish K., additional, Agrawal, Basheal M., additional, Ahluwalia, Manmeet S., additional, Ahmad, Faiz, additional, Air, Ellen, additional, Ajler, Pablo, additional, Albuquerque, Felipe C., additional, Amar, Arun P., additional, Amendola, Luca, additional, Ames, Christopher, additional, Amin, Beejal Y., additional, Amin-Hanjani, Sepideh, additional, Ammerman, Joshua M., additional, Anderson, William S., additional, Apfelbaum, Ronald I., additional, Apuzzo, Michael L.J., additional, Armonda, Rocco, additional, Arnold, Paul M., additional, Arzi, Harel, additional, Asthagiri, Ashok R., additional, Auguste, Kurtis, additional, Awad, Tariq E., additional, Aziz, Khaled M., additional, Aziz, Tipu, additional, Baehring, Joachim M., additional, Baig, Mirza N., additional, Bakay, Roy, additional, Ball, Perry A., additional, Bandiera, Stefano, additional, Barbaro, Nicholas M., additional, Barker, Frederick G., additional, Barrow, Daniel L., additional, Batra, Sachin, additional, Bederson, Joshua, additional, Bekelis, Kimon, additional, Bellabarba, Carlo, additional, Bello, Lorenzo, additional, Belzberg, Allan J., additional, Bendok, Bernard R., additional, Benes, Ludwig, additional, Benzel, Edward C., additional, Bertalanffy, Helmut, additional, Bettegowda, Chetan, additional, Bhatia, Ravi, additional, Bhatia, Sanjay, additional, Bishop, Allen T., additional, Black, Keith L., additional, Blevins, Lewis S., additional, Blike, George T., additional, Blitz, Ari, additional, Blomstedt, Göran C., additional, Blondel, Benjamin, additional, Boahene, Kofi, additional, Boleaga, Bernardo, additional, Bookland, Markus, additional, Boriani, Stefano, additional, Boxell, Christopher M., additional, Brem, Henry, additional, Bricolo, Albino, additional, Brodkey, Jason A., additional, Brotchi, Jacques, additional, Bruce, Jeffrey N., additional, Bruneau, Michael, additional, Buchbinder, Bradley R., additional, Burchiel, Kim J., additional, Burke, Timothy G., additional, Bydon, Ali, additional, Cacciola, Francesco, additional, Cahill, Kevin, additional, Cappabianca, Paolo, additional, Caputy, Anthony J., additional, Cardinale, Francesco, additional, Carrau, Ricardo L., additional, Carson, Benjamin S., additional, Carter, Bob S., additional, Casaceli, Giuseppe, additional, Castana, Laura, additional, Castillo, Gabriel, additional, Cavallo, Luigi M., additional, Cawley, C. Michael, additional, Chakraborty, Aabir, additional, Chang, Edward F., additional, Chang, Eric C., additional, Chang, Steven D., additional, Chapman, Jens R., additional, Chappell, E. Thomas, additional, Chaudhary, Neeraj, additional, Chen, Douglas, additional, Chen, James, additional, Chen, Linda C., additional, Cheng, Boyle C., additional, Chern, Joshua J., additional, Chi, John H., additional, Chien, Wade W., additional, Chiocca, E. Antonio, additional, Chitale, Rohan, additional, Chitnavis, Bhupal, additional, Christiano, Lana D., additional, Chu, Ray M., additional, Ciceri, Elisa F., additional, Clarke, Michelle J., additional, Cohen, Alan, additional, Colao, Annamaria, additional, Colby, Geoffrey P., additional, Collice, Massimo, additional, Condit, Daniel, additional, Coon, Alexander L., additional, Corrêa Dos Reis, Cassius Vinícius, additional, Cosgrove, G. Rees, additional, Cossu, Massimo, additional, Couldwell, William T., additional, Curry, William T., additional, Dabus, Guilherme, additional, Dagi, Teodoro Forcht, additional, D'Aliberti, Giuseppe, additional, Danielpour, Moise, additional, Dannenbaum, Mark J., additional, Dardis, Ronan M., additional, Dasenbrock, Hormuzdiyar H., additional, Dashti, Reza, additional, Day, Arthur L., additional, Day, John Diaz, additional, Deletis, Vedran, additional, Del-Valle, Ramiro, additional, DeMonte, Franco, additional, Dimeco, Francesco, additional, Dodd, Robert, additional, Doglietto, Francesco, additional, Dörner, Lutz, additional, Dorsi, Michael J., additional, Doumit, Gaby D., additional, Drake, James M., additional, Drazin, Doniel, additional, Du, Rose, additional, Ducker, Thomas B., additional, Duffau, Hugues, additional, Duhon, Bradley S., additional, Eboli, Paula, additional, Elhammady, Mohamed Samy, additional, Ely, Pamela, additional, Epstein, Nancy E., additional, Erkmen, Kadir, additional, Errico, Thomas, additional, Eskandar, Emad N., additional, Eskey, Clifford J., additional, Esposito, Felice, additional, Fadul, Camilo E., additional, Fanciullo, Gilbert J., additional, Fargen, Kyle M., additional, Felsen, Gidon, additional, Feng, Dong Xia, additional, Fessler, Richard G., additional, Filler, Aaron G., additional, Flickinger, John C., additional, Floyd, John R., additional, Foley, Kevin T., additional, Fountas, Kostas N., additional, Francis, Howard, additional, Frazier, James L., additional, Frerichs, Kai, additional, Frim, David M., additional, Froelich, Sebastien, additional, Fukushima, Takanori, additional, Gailloud, Philippe, additional, Gaini, Sergio Maria, additional, Gandhi, Chirag D., additional, Gandhi, Dheeraj, additional, Gardner, Gale, additional, Gardner, Paul, additional, Garrett, Mark, additional, Garzón-Muvdi, Tomás, additional, Gasbarrini, Alessandro, additional, Geisler, Fred H., additional, Gemmete, Joseph J., additional, Gerosa, Massimo, additional, Goel, Atul, additional, Gokaslan, Ziya L., additional, Gonzalez, L. Fernando, additional, Goodwin, C. Rory, additional, Goto, Takeo, additional, Gould, Grahame C., additional, Grady, M. Sean, additional, Grande, Andrew W., additional, Grandhi, Ramesh, additional, Green, Alexander L., additional, Greenfield, Jeffrey P., additional, Gross, Bradley A., additional, Grossman, Rachel, additional, Groves, Mari, additional, Guinto, Gerardo, additional, Gullan, Richard, additional, Gupta, Gaurav, additional, Gupta, Nalin, additional, Hankinson, Todd C., additional, Hansasuta, Ake, additional, Harrop, James S., additional, Harsh, Griffith R., additional, Hdeib, Alia, additional, Heinze, Stefan, additional, Heiss, John, additional, Hellwig, Dieter, additional, Hernesniemi, Juha, additional, Heros, Roberto C., additional, Hillman, Todd, additional, Hinojosa, Jose, additional, Hiremath, Girish K., additional, Hoh, Brian L., additional, Hopkins, L. Nelson, additional, Hsu, Wesley, additional, Hu, Yin C., additional, Huang, Jason H., additional, Huang, Judy, additional, Hutchinson, Peter J., additional, Hyam, Jonathan A., additional, Ioachimescu, Adriana G., additional, Jabbour, Pascal M., additional, Jackson, Juan, additional, Jallo, George I., additional, Janecka, Ivo P., additional, Javadpour, Mohsen, additional, Jea, Andrew, additional, Jeswani, Sunil, additional, Jho, David H., additional, Jho, Diana H., additional, Jho, Hae-Dong, additional, Jiang, Bowen, additional, Jung, Tae-Young, additional, Kalani, M. Yashar S., additional, Kano, Hideyuki, additional, Kapadia, Silloo B., additional, Kaplitt, Michael G., additional, Kappus, Christoph, additional, Kapsalaki, Eftychia Z., additional, Karmon, Yuval, additional, Kassam, Amin B., additional, Kathuria, Sudhir, additional, Kawase, Takeshi, additional, Khalessi, Alexander A., additional, Khu, Kathleen, additional, Kim, Daniel H., additional, Kirsch ., Matthias, additional, Kivisaari, Riku, additional, Kolias, Angelos G., additional, Kondziolka, Douglas, additional, Korinth, Marcus C, additional, Krex, Dietmar, additional, Krieger, Mark D., additional, Krishnan, Kartik G., additional, Krishnaney, Ajit A., additional, Lacy, Maureen, additional, Lad, Santosh D., additional, Landeiro, Jose Alberto, additional, Lang, Frederick F., additional, Lang, Shih-Shan, additional, LaPierre, Françoise, additional, Larson, Paul S., additional, Lawton, Michael T., additional, Lee, Marco, additional, Lehecka, Martin, additional, Levi, Allan, additional, Levy, Elad I., additional, Lieberson, Robert E., additional, Lim, Michael, additional, Lin, Ning, additional, Lind, Göran, additional, Linderoth, Bengt, additional, Lindley, Timothy, additional, Listrat, Antoine, additional, Liu, Charles Y., additional, Liu, James K., additional, Liu, John C., additional, Lo Russo, Giorgio, additional, Loftus, Christopher M., additional, Lonser, Russell R., additional, Lu, Daniel C., additional, Lu, Yi, additional, Lunsford, L. Dade, additional, Macenski, M. Mason, additional, Maciaczyk, Jaroslaw, additional, Madsen, Joseph R., additional, Magge, Subu N., additional, Maira, Giulio, additional, Malessy, Martijn J.A., additional, Malone, David G., additional, Maniker, Allen, additional, Manley, Geoffrey T., additional, Manwaring, Jotham, additional, Martineau, Mitchell, additional, Martuza, Robert L., additional, Mathews, Marlon S., additional, Mathioudakis, Nestoras, additional, McCormick, Paul, additional, McDermott, Michael W., additional, McDougall, Cameron G., additional, Mehdorn, H. Maximilian, additional, Mehta, Vivek A., additional, Menezes, Arnold, additional, Mertens, Patrick, additional, Meyer, Frederic B., additional, Mian, Matthew K., additional, Midha, Rajiv, additional, San Millán Ruíz, Diego, additional, Miller, Jonathan, additional, Miller, Neil R., additional, Mirzadeh, Zaman, additional, Mishra, Ganpati Prasad, additional, Missios, Symeon, additional, Mitchell, James B., additional, Mitha, Alim, additional, Mocco, J., additional, Moghekar, Abhay, additional, Morcos, Jacques J., additional, Morgan, Chad J., additional, Morrison, John F., additional, Moyle, Henry, additional, Muh, Carrie R., additional, Mukherjee, Debraj, additional, Nabavi, Arya, additional, Nanaszko, Michael J., additional, Nandi, Dipankar, additional, Narayan, Raj, additional, Natarajan, Sabareesh K., additional, Nathal, Edgar, additional, Nayar, Vikram V., additional, Netalkar, Audumbar Shantaram, additional, Newman, C. Benjamin, additional, Nguyen, Trang, additional, Ngwenya, Laura B., additional, Nicolato, Antonio, additional, Niemelä, Mika, additional, Nikkhah, Guido, additional, Nimmagadda, Anitha, additional, Niparko, John K., additional, Niranjan, Ajay, additional, North, Richard B., additional, Núñez, José María, additional, Oakes, W. Jerry, additional, Ogilvy, Christopher S., additional, Ohata, Kenji, additional, Ojemann, Jeffrey G., additional, Ojemann, Steven, additional, Okonkwo, David O., additional, Oldfield, Edward H., additional, O'Neill, Brent, additional, Oyesiku, Nelson M., additional, Pallini, Roberto, additional, Pandey, Aditya S., additional, Pang, Dachling, additional, Papadimitriou, Kyriakos, additional, Pascual, José María, additional, Patel, Aman, additional, Patel, Anoop P., additional, Patel, Toral R., additional, Paterno, Vincenzo, additional, Patir, Rana, additional, Paul, Alexandra R., additional, Pawar, Sanjay J., additional, Penn, Richard, additional, Pereira, Erlick A.C., additional, Perez-Cruet, Mick J., additional, Peterson, Eric C., additional, Pichelmann, Mark A., additional, Piepmeier, Joseph M., additional, Pinsker, Marcus O., additional, Pitts, Lawrence H., additional, Placide, Rick J., additional, Pondaag, Willem, additional, Post, Kalmon, additional, Potts, Matthew B., additional, Poulsgaard, Lars, additional, Pradilla, Gustavo, additional, Prestigiacomo, Charles J., additional, Prevedello, Daniel M., additional, Prieto, Ruth, additional, Quiñones-Hinojosa, Alfredo, additional, Quintana, Leonidas M., additional, Rahimi, Scott Y., additional, Rahme, Rudy J., additional, Ramos-Zúñiga, Rodrigo, additional, Ranalli, Nathan J., additional, Raza, Shaan M., additional, Recinos, Pablo F., additional, Recinos, Violette Renard, additional, Rege, Shrikant, additional, Reithmeier, Thomas, additional, Relyea, Katherine, additional, Resnick, Daniel, additional, Rigamonti, Daniele, additional, Rigoard, Philippe, additional, Rinne, Jaakko, additional, Robertson, Jon H., additional, Rochkind, Shimon, additional, Rock, Jack P., additional, Romani, Rossana, additional, Rosenthal, Guy, additional, Rosenwasser, Robert H., additional, Rowland, Nathan C., additional, Rutka, James T., additional, Ryu, Samuel, additional, Sala, Francesco, additional, Salvatori, Roberto, additional, Sammalkorpi, Kari, additional, Sanai, Nader, additional, Santarius, Thomas, additional, Saxena, Amar, additional, Schackert, Gabriele, additional, Schick, Uta, additional, Schildhauer, Thomas A., additional, Schmidek, Alexandra, additional, Schmidek, Henry H., additional, Schmidt, Meic H., additional, Schmitt, Paul, additional, Schramm, Johannes, additional, Schwab, Joseph, additional, Schwartz, Theodore H., additional, Schweder, Patrick, additional, Sciubba, Daniel M., additional, Scott, R. Michael, additional, Sekula, Raymond F., additional, Senatus, Patrick, additional, Shad, Amjad, additional, Shaibani, Ali, additional, Sharma, Manish S., additional, Sharma, Rewati Raman, additional, Sheth, Sameer A., additional, Shin, Alexander Y., additional, Shirzadi, Ali, additional, Siddiqui, Adnan H., additional, Silveira, Roberto Leal, additional, Simmons, Nathan E., additional, Sindou, Marc, additional, Sinisi, Marco, additional, Siu, Timothy, additional, Smith, Edward, additional, Smith, Joseph R., additional, Smith, Patricia, additional, Smyth, Matthew, additional, Solari, Domenico, additional, Solomon, David, additional, Sonabend, Adam M., additional, Souweidane, Mark M., additional, Spagnuolo, Edgardo, additional, Spetzler, Robert F., additional, Spinner, Robert J., additional, Stark, Andreas M., additional, Starr, Philip A., additional, Steiner, Ladislau, additional, Steinmetz, Michael P., additional, Stiver, Shirley I., additional, Subramanian, Prem, additional, Sughrue, Michael E., additional, Suk, Ian, additional, Sun, Daniel Q., additional, Sure, Ulrich, additional, Szentirmai, Oszkar, additional, Taghva, Alexander, additional, Talamonti, Giuseppe, additional, Tamargo, Rafael J., additional, Teff, Richard J., additional, Tew, John M., additional, Theodore, Nicholas, additional, Theodosopoulos, Philip V., additional, Thompson, B. Gregory, additional, Tirakotai, Wuttipong, additional, Tjoumakaris, Stavropoula I., additional, Tonsgard, James H., additional, Trejo, David, additional, Trippel, Michael, additional, Tubbs, R. Shane, additional, Tumialan, Luis M., additional, Unterberg, Andreas, additional, Vaphiades, Michael S., additional, Vaughan, T. Brooks, additional, Veeravagu, Anand, additional, Velasco, Ana Luisa, additional, Velasco, Francisco, additional, Velat, Gregory J., additional, Verlicchi, Angela, additional, Vrionis, Frank D., additional, Wager, Michel, additional, Wallace, M. Christopher, additional, Wand, Gary S., additional, Warf, Benjamin C., additional, Waters, Michael F., additional, Watson, Joseph, additional, Weiss, Martin H., additional, Weiss, Nirit, additional, Welch, William, additional, Werner, J. Kent, additional, Whitworth, Louis A., additional, Winfree, Christopher, additional, Witham, Timothy F., additional, Wolinsky, Jean-Paul, additional, Wong, Judith M., additional, Xavier, Shaun, additional, Yamini, Bakhtiar, additional, Yampolsky, Claudio, additional, Yaremchuk, Michael J., additional, Yassari, Reza, additional, Yen, Chun-Po, additional, Yianni, John, additional, Yu, Alexander K., additional, Zager, Eric L., additional, Zanotti, Bruno, additional, Zenteno, Marco, additional, Zileli, Mehmet, additional, and Zouzias, Alexandros D., additional

Published
2012
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