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24 results on '"Dawson, Dolphus R."'

13. Comparison of Dehydrated Human Amnion-Chorion and Type 1 Bovine Collagen Membranes in Alveolar Ridge Preservation: A Clinical and Histological Study.

Author

Faraj, Samer A., Kutkut, Ahmad, Taylor, Robert C., Villasante-Tezanos, Alejandro, Huja, Sarandeep S., Dawson, Dolphus R., Almehmadi, Nehal, and Al-Sabbagh, Mohanad

Subjects
ALVEOLAR process, COLLAGEN, BONE growth, BOS, HUMAN beings
Abstract

Alveolar ridge preservation maintains ridge dimensions and bone quality for implant placement. The aim of this randomized controlled clinical study is to compare the use of a human amnion-chorion membrane to a collagen membrane in an exposed-barrier ridge preservation technique. Furthermore, this study will determine if intentional membrane exposure compromises ridge dimensions and bone vitality. Forty-three patients requiring extraction and delayed implant placement were randomly assigned into either the experimental or control group. Twenty-one participants received human amnion-chorion membrane (test) during ridge preservation while 22 participants received the collagen membrane (control). In both groups, demineralized freeze-dried bone allografts were used to graft the socket and primary closure was not achieved. The patients underwent implant placement after an average healing period of 19.5 weeks, and 2.7 × 8-mm core bone specimens were obtained for histomorphometric analyses. The clinical ridge dimensions were measured after extraction and at the time of delayed implant placement. No significant difference was observed in the mean vital bone formation between the experimental (51.72 ± 8.46%) and control (49.96 ± 8.31%; P >.05) groups. The bone height and width did not differ, as determined by clinical measurements (P >.05). Using either a human amnion-chorion membrane or type 1 bovine collagen as the open barrier did not change healing, compromise ridge dimensions, or affect bone vitality between the 2 groups. [ABSTRACT FROM AUTHOR]

Published
2021
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15. Tissue Engineering

Author

Dawson, Dolphus R., primary, El-Ghannam, Ahmed, additional, Van Sickels, Joseph E., additional, and Naung, Noel Ye, additional

Published
2019
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16. Salivary Biomarkers of Periodontal Disease in Response to Treatment

Author

Sexton, William Michael, Lin, Yushun, Kryscio, Richard J., Dawson, Dolphus R., Ebersole, Jeffrey L., and Miller, Craig S.

Subjects
Adult, Male, Interleukin-1beta, Severity of Illness Index, Article, Humans, Single-Blind Method, Longitudinal Studies, Salivary Proteins and Peptides, Saliva, Aged, Chemokine CCL3, Analysis of Variance, Tumor Necrosis Factor-alpha, Interleukin-8, Osteoprotegerin, Dental Prophylaxis, Middle Aged, Oral Hygiene, Matrix Metalloproteinase 8, Treatment Outcome, ROC Curve, Case-Control Studies, Chronic Periodontitis, Female, Periodontal Index, Biomarkers
Abstract

Salivary biomarkers of periodontitis were assessed longitudinally to determine response to therapy.A 6-month case-controlled study of adults with chronic periodontitis was performed, with 33 participants receiving oral hygiene instructions (OHI) alone and 35 with scaling and root planing (SRP) combined with OHI. Saliva samples collected at week 0, 16 and 28 were analysed for interleukin (IL)-1β, IL-8, macrophage inflammatory protein (MIP)-1α, matrix metalloproteinase-8 (MMP-8), osteoprotegerin (OPG), and tumour necrosis factor-α (TNF)-α. Clinical measures of periodontal disease were recorded at each visit.All parameters of periodontal health improved significantly in both groups by week 16 (p0.0001) with the SRP group demonstrating greater benefit at week 16 and 28. Baseline OPG and TNF-α levels changed significantly at both follow-up visits (p0.03), regardless of treatment group. IL-1β and MMP-8 levels decreased significantly from baseline (p0.04) in the SRP group only. OPG, MMP-8, and MIP-1α were significantly reduced in responders compared with non-responders (p=0.04, 0.01, 0.05, respectively). In receiver-operating characteristic analyses, MMP-8 produced the highest area under the curve (0.7; p=0.01).Salivary levels of IL-1β, MMP-8, OPG, and MIP-1α reflected disease severity and response to therapy suggesting their potential utility for monitoring periodontal disease status.

Published
2011

18. Authors' response re: “Diffrential sex effects of nutritional statics on inflammatory periodontal disease in non-human primates

Author

Reynolds, Mark A., primary, Branch-Mays, Grishondra L., additional, Dawson, Dolphus R., additional, Novak, Karen F., additional, Ebersole, Jeffrey L., additional, Novak, M. John, additional, Gunsolley, John C., additional, Holt, Stanley C., additional, Mattison, Julie A., additional, and Ingram, Donald K., additional

Published
2010
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22. Modified‐Release Subantimicrobial Dose Doxycycline Enhances Scaling and Root Planing in Subjects With Periodontal Disease

Author

Preshaw, Philip M., primary, Novak, M. John, additional, Mellonig, James, additional, Magnusson, Ingvar, additional, Polson, Alan, additional, Giannobile, William V., additional, Rowland, Randal W., additional, Thomas, John, additional, Walker, Clay, additional, Dawson, Dolphus R., additional, Sharkey, Dennis, additional, and Bradshaw, Mark H., additional

Published
2008
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23. Combining Host Modulation and Topical Antimicrobial Therapy in the Management of Moderate to Severe Periodontitis: A Randomized Multicenter Trial

Author

Novak, M. John, primary, Dawson, Dolphus R., additional, Magnusson, Ingvar, additional, Karpinia, Katherine, additional, Polson, Alan, additional, Polson, Anne, additional, Ryan, Maria E., additional, Ciancio, Sebastian, additional, Drisko, Connie H., additional, Kinane, Denis, additional, Powala, Christopher, additional, and Bradshaw, Mark, additional

Published
2008
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