Search

Your search keyword '"Dawood F"' showing total 330 results
Start Over Author "Dawood F"
330 results on '"Dawood F"'

5. Recombinant human granulocyte– colony stimulating factor in women with unexplained recurrent pregnancy losses: a randomized clinical trial

Author

Eapen, A, Joing, M, Kwon, P, Tong, J, Maneta, E, De Santo, C, Mussai, F, Lissauer, D, Carter, D, Ahmed, A, Bass, C, Benderatik, R, Bhattacharya, R, Cheong, Y, Dawood, F, Granne, I, Gupta, P, Horne, A, Manda, P, Mohiyiddeen, L, Moore, J, Quenby, S, Rai, R, Shillito, J, Stewart, J, Truchanowicz, E, Dwyer, L, Small, R, Sharpe, L, Smith, A, Coomarasamy, A, and Grp, RESPONSE Study

Subjects
safety, medicine.medical_specialty, abortion, spontaneous, unexplained recurrent miscarriages, Population, adverse event, immune mediated miscarriages, live birth, law.invention, Miscarriage, recombinant human granulocyte colony stimulating factor, 03 medical and health sciences, semi-allogenic fetus, 0302 clinical medicine, Randomized controlled trial, law, congenital abnormality, antidrug antibody, Recurrent miscarriage, cytokine, Medicine, neutropenia, education, education.field_of_study, Pregnancy, pregnancy outcome, 030219 obstetrics & reproductive medicine, recurrent pregnancy loss, abortion, habitual, business.industry, Obstetrics, Rehabilitation, Obstetrics and Gynecology, medicine.disease, Early Pregnancy, recombinant granulocyte colony stimulating factor, Clinical trial, Reproductive Medicine, Gestation, Original Article, pregnancy, granulocyte colony-stimulating factor, business, Live birth
Abstract

Study question Does administration of recombinant human granulocyte colony stimulating factor (rhG-CSF) in the first trimester improve pregnancy outcomes, among women with a history of unexplained recurrent pregnancy loss? Summary answer rhG-CSF administered in the first trimester of pregnancy did not improve outcomes among women with a history of unexplained recurrent pregnancy loss. What is known already The only previous randomized controlled study of granulocyte colony stimulating factor in recurrent miscarriage in 68 women with unexplained primary recurrent miscarriage found a statistically significant reduction in miscarriage and improvement in live birth rates. A further four observational studies where G-CSF was used in a recurrent miscarriage population were identified in the literature, two of which confirmed statistically significant increase in clinical pregnancy and live birth rates. Study design, size, duration A randomized, double-blind, placebo controlled clinical trial involving 150 women with a history of unexplained recurrent pregnancy loss was conducted at 21 sites with established recurrent miscarriage clinics in the United Kingdom between 23 June 2014 and 05 June 2016. The study was coordinated by University of Birmingham, UK. Participants/materials, setting, methods One hundred and fifty women with a history of unexplained recurrent pregnancy loss: 76 were randomized to rhG-CSF and 74 to placebo. Daily subcutaneous injections of recombinant human granulocyte – colony stimulating factor 130 μg or identical appearing placebo from as early as three to five weeks of gestation for a maximum of 9 weeks. The trial used central randomization with allocation concealment. The primary outcome was clinical pregnancy at 20 weeks of gestation, as demonstrated by an ultrasound scan. Secondary outcomes included miscarriages, livebirth, adverse events, stillbirth, neonatal birth weight, changes in clinical laboratory variables following study drug exposure, major congenital anomalies, preterm births and incidence of anti-drug antibody formation. Analysis was by intention to treat. Main results and the role of chance A total of 340 participants were screened for eligibility of which 150 women were randomized. 76 women (median age, 32[IQR, 29–34] years; mean BMI, 26.3[SD, 4.2]) and 74 women (median age, 31[IQR, 26–33] years; mean BMI, 25.8[SD, 4.2]) were randomized to placebo. All women were followed-up to primary outcome, and beyond to live birth. The clinical pregnancy rate at 20 weeks, as well as the live birth rate, was 59.2% (45/76) in the rhG-CSF group, and 64.9% (48/74) in the placebo group, giving a relative risk of 0.9 (95% CI: 0.7–1.2;P= 0.48). There was no evidence of a significant difference between the groups for any of the secondary outcomes. Adverse events (AEs) occurred in 52 (68.4%) participants in rhG-CSF group and 43 (58.1%) participants in the placebo group. Neonatal congenital anomalies were observed in 1/46 (2.1%) of babies in the rhG-CSF group versus 1/49 (2.0%) in the placebo group (RR of 0.9; 95% CI: 0.1–13.4;P= 0.93). Limitations, reasons for caution This trial was conducted in women diagnosed with unexplained recurrent pregnancy loss and therefore no screening tests (commercially available) were performed for immune dysfunction related pregnancy failure/s. Wider implications of the findings To our knowledge, this is the first multicentre study and largest randomized clinical trial to investigate the efficacy and safety of granulocyte human colony stimulating factor in women with recurrent miscarriages. Unlike the only available single center RCT, our trial showed no significant increase in clinical pregnancy or live births with the use of rhG-CSF in the first trimester of pregnancy. Study funding/competing interest(s) This study was sponsored and supported by Nora Therapeutics, Inc., 530 Lytton Avenue, 2nd Floor, Palo Alto, CA 94301, USA. Darryl Carter was the co-founder and VP of research, Nora Therapeutics, Inc. and held shares in the company. He holds a patent for the use of recombinant human granulocyte colony stimulating factor to reduce unexplained recurrent pregnancy loss. Mark Joing, Paul Kwon and Jeff Tong were or are employees of Nora Therapeutics, Inc. No other potential conflict of interest relevant to this article was reported. Trial registration number EUDRACT No: 2014-000084-40; ClinicalTrials.gov Identifier: NCT02156063 Trial registration date 31 Mar 2014 Date of first patient’s enrolment 23 Jun 2014

Published
2019

15. Caesarean scar pregnancy in the UK: a national cohort study

Author

Harb, HM, primary, Knight, M, additional, Bottomley, C, additional, Overton, C, additional, Tobias, A, additional, Gallos, ID, additional, Shehmar, M, additional, Farquharson, R, additional, Horne, A, additional, Latthe, P, additional, Edi-Osagie, E, additional, MacLean, M, additional, Marston, E, additional, Zamora, J, additional, Dawood, F, additional, Small, R, additional, Ross, J, additional, Bourne, T, additional, Coomarasamy, A, additional, and Jurkovic, D, additional

Published
2018
Full Text
View/download PDF

20. Neurologic complications associated with novel influenza A (H1N1) virus infection in children--Dallas, Texas, May 2009

Author

Evans, A.S., Agadi, S., Siegel, J.D., Chung, W.M., Carlo, J.T., Uyeki, T.M., Sejvar, J., Lindstrom, S., Erdman, D., Oberste, S., Olsen, S.J., Dawood, F., and Morgan, O.W.

Subjects
Patient monitoring -- 2009 AD, Swine influenza -- Complications and side effects, Dallas, Texas -- Health aspects
Abstract

Neurologic complications, including seizures, encephalitis, encephalopathy, Reye syndrome, and other neurologic disorders, have been described previously in association with respiratory tract infection with seasonal influenza A or B viruses (1-2), [...]

Published
2009

21. Influenza activity--United States and worldwide, May 18-September 19, 2008

Author

Brammer, L., Epperson, S., Blanton, L., Dhara, R., Wallis, T., Finelli, L., Fiore, A., Gubareva, L., Bresee, J., Klimov, A., Cox, N., and Dawood, F.

Subjects
Vaccination -- Statistics, Influenza vaccines -- Dosage and administration, Health promotion -- Methods, Influenza -- Prevention
Abstract

During May 18-September 19, 2008, influenza A (H1), influenza A (H3), and influenza B viruses were detected worldwide and were identified sporadically in the United States. This report summarizes influenza [...]

Published
2008

24. Chronic endothelin-1 blockade preserves myocardial contractility in dilated cardiomyopathy

Author

A. Pandey, Peter Liu, Duncan J. Stewart, Wen Wh, Cernacek P, and Dawood F

Subjects
Inotrope, Cardiomyopathy, Dilated, Endothelin Receptor Antagonists, Male, medicine.medical_specialty, Myocarditis, Lusitropy, Heart disease, Cardiomyopathy, Carboxylic Acids, Contractility, Mice, Internal medicine, medicine, Animals, Pharmacology, Endothelin-1, business.industry, Myocardium, Hemodynamics, Dilated cardiomyopathy, medicine.disease, Receptor, Endothelin A, Myocardial Contraction, Endocrinology, Mice, Inbred DBA, Heart failure, Indans, cardiovascular system, Cardiology, Cardiology and Cardiovascular Medicine, business
Abstract

Endothelin-1 (ET-1) is known to have positive inotropic effects in isolated cardiac muscle strips. ET-1 levels are elevated in congestive heart failure (CHF). We investigated the effects of ET-1 on contractility and cardiac relaxation (lusitropy) of the intact healthy murine heart and myocarditic/cardiomyopathic heart by chronic oral treatment with a mixed ETA/ETB blocker SB217242. Chronic ET-1 blockade of normal hearts resulted in depression of contractility and lusitropy of the normal heart but preservation and enhancement of contractility and lusitropy in myocarditic animals, in which ET-1 cardiac content is elevated. This suggests that ET-1 is important in the basal contractility and relaxation of the normal heart but that its chronic elevation in CHF causes impairment of cardiac systolic and diastolic performance.

Published
1998

28. 378 ERp44 Deficiency in Mice, Zebrafish and Mouse-Derived Embryonic Stem Cell Derived Cardiomyocytes Display Aberrant Ca2 Homeostasis, ER Stress Induced Apoptosis and Cardiomyopathy

Author

Wang, D.Y., primary, Abbasi, C., additional, Li, Y.J., additional, El-Rass, S., additional, Tang, G., additional, Dawood, F., additional, Naito, K., additional, Yokoe, S., additional, Wilson, A., additional, Sharma, P., additional, Wen, X.Y., additional, Liu, P., additional, and Gramolini, A., additional

Published
2012
Full Text
View/download PDF

36. SELECTED ORAL COMMUNICATION SESSION, SESSION 34: EARLY PREGNANCY LOSS PROGNOSIS AND TREATMENT, Tuesday 5 July 2011 10:00 - 11:30

Author

Tang, A. W., primary, Alfirevic, Z., additional, Turner, M. A., additional, Drury, J., additional, Topping, J., additional, Dawood, F., additional, Farquharson, R., additional, Quenby, S., additional, Adam, K., additional, Entwisle, M., additional, O'Toole, K., additional, Bhima, G., additional, Palep-Singh, M., additional, Edi-Osagie, E., additional, Abediasl, Z., additional, Moini, M., additional, Jansen, E., additional, Stoop, D., additional, Ermini, B., additional, Haentjens, P., additional, De Vos, M., additional, Polyzos, N., additional, Verheyen, G., additional, Devroey, P., additional, Cabar, F. R., additional, P. Pereira, P., additional, Francisco, R. P., additional, Zugaib, M., additional, Horiuchi, R., additional, Miyaji, S., additional, Haruki, A., additional, Fukuda, A., additional, and Morimoto, Y., additional

Published
2011
Full Text
View/download PDF

37. POSTER VIEWING SESSION - EARLY PREGNANCY

Author

Kamijo, T., primary, Milart, P., additional, Wojcik, K., additional, Szkodziak, P., additional, Wozniak, S., additional, Czuczwar, P., additional, Paszkowski, T., additional, Landolsi, H., additional, Yacoubi, M. T., additional, Stita, W., additional, Gribaa, M., additional, Hmissa, S., additional, Molenaar, N., additional, van Besouw, N. H., additional, Steegers, E. A. P., additional, Visser, W., additional, de Kuiper, P., additional, de Krijger, R., additional, Exalto, N., additional, Lagrand, R., additional, Kaandorp, S. P., additional, Mellink, C. H. M., additional, van Wely, M., additional, Redeker, E. J. W., additional, Knegt, A. C., additional, Goddijn, M., additional, Vidal, C., additional, Giles, J., additional, Meseguer, M., additional, Zuzuarregui, J. L., additional, Bosch, E., additional, Pellicer, A., additional, Schust, D., additional, Sugimoto, M., additional, Sugimoto, J., additional, Reus, A. D., additional, Stephenson, M. D., additional, Krijger de, R. R., additional, Dunne van, F. M., additional, Exacoustos, C., additional, Vaquero, E., additional, Di Giovanni, A., additional, Romeo, V., additional, Lazzarin, N., additional, Arduini, D., additional, Brahem, S., additional, Mehdi, M., additional, Atig, F., additional, Ghedir, H., additional, Ibala, S., additional, Ajina, M., additional, Saad, A., additional, Chang, C., additional, Wang, H., additional, Huang, S., additional, Pai, S., additional, Soong, Y., additional, Papanikolaou, E., additional, Pantos, G., additional, Grimbizis, G., additional, Bili, E., additional, Polyzos, N., additional, Karastefanou, K., additional, Humaidan, P., additional, Esteves, S., additional, Tarlatzis, B., additional, McNamee, K., additional, Topping, A., additional, Farquharson, R. G., additional, Dawood, F., additional, Ruiz Galdon, M., additional, Lendinez, A. M., additional, Palomares, A. R., additional, Martinez, F., additional, Perez-Nevot, B., additional, Jimenez Fernandez, A., additional, Reyes-Engel, A., additional, Horcajadas, J. A., additional, Savaris, R. F., additional, Kovac, V., additional, Reljic, M., additional, Vlaisavljevic, V., additional, Colicchia, A., additional, Pergolini, I., additional, Gilio, B., additional, Rampini, M. R., additional, Alfano, P., additional, Marconi, D., additional, Verlengia, C., additional, Alviggi, E., additional, Bellver, J., additional, Cruz, F., additional, Martinez, M. C., additional, Ramirez, J., additional, Ferro, J., additional, Garrido, N., additional, Brown, J. K., additional, Lauer, K. B., additional, Inglis, N. F., additional, Critchley, H. O. D., additional, Horne, A. W., additional, Samli, H., additional, Cetinkaya Demir, B., additional, Ozgoz, A., additional, Atalay, M. A., additional, Uncu, G., additional, Yan, Y., additional, Cai-hong, M. A., additional, Jie, Q. I. A. O., additional, Xin-na, C. H. E. N., additional, Weimar, C. H. E., additional, Kavelaars, A., additional, Gellersen, B., additional, Brosens, J. J., additional, de Vreeden-Elbertse, J. M. T., additional, Heijnen, C. J., additional, Macklon, N. S., additional, Castillo, J. C., additional, Dolz, M., additional, Caballero, O., additional, Abad, L., additional, Perez-Panades, J., additional, Bonilla-Musoles, F., additional, Eggert - Kruse, W., additional, Scholz, S., additional, Klopsch, I., additional, and Strowitzki, T., additional

Published
2011
Full Text
View/download PDF

40. Posters * Early Pregnancy

Author

Christiansen, O., primary, Dahl, M., additional, Nielsen, H. S., additional, Kolte, A. M., additional, Larsen, E. C., additional, Hviid, T. V., additional, Pike, J., additional, Ellis, J., additional, Johnson, S., additional, Shaw, R., additional, Parkinson, P., additional, Perry, P., additional, Kuji, N., additional, Okumura, N., additional, Takano, M., additional, Ogawa, S., additional, Yamada, M., additional, Hamatani, T., additional, Yoshimura, Y., additional, Kawakami, M., additional, Hirayama, A., additional, Tomita, M., additional, Shaw, J. L. V., additional, Wills, G. S., additional, McClure, M. O., additional, Horner, P. J., additional, Colgan, A., additional, Jabbour, H. N., additional, Critchley, H. O. D., additional, Entrican, G., additional, Horne, A. W., additional, Dosen, M., additional, Vlaisavljevic, V., additional, Kovacic, B., additional, Horlbeck, S., additional, Kirschfink, M., additional, Ziegler, A., additional, Strowitzki, T., additional, Eggert-Kruse, W., additional, Lambers, M. J., additional, Groeneveld, E., additional, Hoozemans, D. A., additional, Schats, R., additional, Hompes, P. G. A., additional, Lambalk, C. B., additional, Wu, F., additional, Aghai, Z., additional, Steffensen, R., additional, van Halteren, A. G. S., additional, Spierings, E., additional, Christiansen, O. B., additional, Miklos, D., additional, Goulmy, E., additional, Seki, T., additional, Sugawara, N., additional, Maeda, M., additional, Manome, T., additional, Araki, Y., additional, Farquharson, R., additional, Dawood, F., additional, Leylek, O., additional, Uner, O., additional, Ozcil, M. D., additional, Baltaci, V., additional, Andersen, D., additional, Lossl, K., additional, Andersen, A. N., additional, Furbringer, J., additional, Bach, H., additional, Simonsen, J., additional, McCartney, J., additional, Dutton, P., additional, Brady, B. M., additional, Oriol, B., additional, Giles, J., additional, Bronet, F., additional, Ruiz, A., additional, Pellicer, A., additional, Garcia-Velasco, J. A., additional, Scarpellini, F., additional, Sbracia, M., additional, Rossi, G., additional, Lam, K. K. W., additional, Chiu, P. C. N., additional, Lee, C. L., additional, Yeung, W. S. B., additional, Ho, P. C., additional, van den Boogaard, E., additional, Cohn, D. M., additional, Korevaar, J. C., additional, Middeldorp, S., additional, Goddijn, M., additional, Farquharson, R. G., additional, Papanikolaou, E., additional, Werpoest, W., additional, Fatemi, H., additional, Polyzos, N., additional, Humaidan, P., additional, Tarlatzis, B., additional, Devroey, P., additional, Tournaye, F., additional, Li, W., additional, Laird, S., additional, Li, T. C., additional, Lathi, R. B., additional, Massie, J., additional, O'leary, K., additional, Druzin, M., additional, Chi, H. B., additional, Ma, C. H., additional, Qiao, J., additional, Du, X. G., additional, Yang, R., additional, Hamilton, C., additional, Brandes, M., additional, Verzijden, J. C. M., additional, de Weys, N. P. C., additional, de Bruin, J. P., additional, Bots, R. S. G. M., additional, Nelen, W. L. D. M., additional, Kremer, J. A. M., additional, Kuhn-Beck, F., additional, Moutel, G., additional, Weingertner, A. S., additional, Kohler, M., additional, Mager, C., additional, Kohler, A., additional, Hunsinger, M. C., additional, Neumann, M., additional, Bouffet, N., additional, Tanghe, M., additional, and Favre, R., additional

Published
2010
Full Text
View/download PDF

44. 18 Liverpool consultants reply

Author

Adams, E., primary, Lewis-Jones, I., additional, Alfirevic, Z., additional, MacDonald, R., additional, Dawood, F., additional, Mallaiah, S., additional, Djabatey, E., additional, Parkinson, D., additional, Farquharson, R., additional, Patrick, D., additional, Fowler, G., additional, Turner, M., additional, Hapangama, D., additional, Wauchob, T., additional, Kingsland, C., additional, Weeks, A., additional, Kingston, R., additional, and Kirwan, J., additional

Published
2009
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results