13 results on '"Dawn Bell"'
Search Results
2. Reviewing Fundamental CO2 Adsorption Characteristics of Zeolite and Activated Carbon by In-situ Measurements With Radioactively Labelled CO2
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Nick Sweygers, Sarah Dawn Bell, Raf Dewil, Andrew Ingram, Jonathan Seville, Lise Appels, Jan Baeyens, Yimin Deng, and Huili Zhang
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In situ ,Materials science ,Air pollution ,Filtration and Separation ,medicine.disease_cause ,Co2 adsorption ,Analytical Chemistry ,Adsorption ,Chemical engineering ,Physisorption ,Chemisorption ,medicine ,Zeolite ,Activated carbon ,medicine.drug - Abstract
Gas adsorption is widely used in air pollution control, with mainly activated carbon and zeolites used as adsorbents. Although physical and chemisorption can be used, most air pollution application...
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- 2021
3. 11CO2 positron emission imaging reveals the in-situ gas concentration profile as function of time and position in opaque gas-solid contacting systems
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Huili Zhang, Yimin Deng, Andrew Ingram, Lise Appels, Jonathan Seville, David Parker, Jan Baeyens, Renaud Ansart, Raf Dewil, Thomas Leadbeater, Sarah Dawn Bell, Centre National de la Recherche Scientifique - CNRS (FRANCE), Institut National Polytechnique de Toulouse - Toulouse INP (FRANCE), Université Toulouse III - Paul Sabatier - UT3 (FRANCE), Beijing University of Technology - BJUT (CHINA), University of Birmingham (UNITED KINGDOM), University of Cape Town - UCT (SOUTH AFRICA), Katholieke Universiteit Leuven - KU LEUVEN (BELGIUM), Laboratoire de Génie Chimique - LGC (Toulouse, France), University of Birmingham [Birmingham], Beijing University of Technology, Laboratoire de génie chimique [ancien site de Basso-Cambo] (LGC), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées, and University of Cape Town
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In situ ,Materials science ,Opacity ,General Chemical Engineering ,Mixing (process engineering) ,02 engineering and technology ,010402 general chemistry ,01 natural sciences ,Industrial and Manufacturing Engineering ,Breakthrough ,Adsorption ,[CHIM.GENI]Chemical Sciences/Chemical engineering ,TRACER ,Mass transfer ,medicine ,Environmental Chemistry ,Génie chimique ,[SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering ,Positron emission ,Génie des procédés ,Astrophysics::Galaxy Astrophysics ,Gas-solid interactions ,medicine.diagnostic_test ,General Chemistry ,021001 nanoscience & nanotechnology ,0104 chemical sciences ,Kinetics ,Positron emission imaging ,Opaque reactors ,Positron emission tomography ,Chemical physics ,0210 nano-technology ,CO2 adsorption - Abstract
International audience; The in situ analysis of industrial processes, mostly conducted in opaque equipment is difficult. Whereas previously the positron emission technique was successfully applied to study the flow and mixing in gas-solid and liquid-solid systems using radio-active tracer particles, research on imaging a radio- active tracer gas is scarce. The present paper demonstrates the use of a fully three-dimensional (3D) Positron Emission Tomography (PET) in imaging the adsorption of 11CO2 tracer gas, while validating the measurement by conventional exit gas analysis. It will be demonstrated that PET can be used to measure the kinetics of high-pressure CO2 adsorption in situ, including the essential breakthrough and mass transfer zone characteristics. Such high-pressure operation is characteristic of pre-combustion CO2 capturing processes. It is expected that this work will foster further studies of gas-solid systems of adsorption, gas-solid catalysis, gas-solid hydrodynamics, and processes where the gas-solidinteraction is of primary importance.
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- 2021
4. E35 Might there be Differences in Drug Survival of Anti-Tumour Necrosis Factor Inhibitors in Real Life? A Review of Routine National Health Service Practice
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Pippa Watson, Sharon Christy-Kilner, Benjamin R. T. Jones, Dawn Bell, and Jordan W. Oldbury
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Oncology ,Drug survival ,medicine.medical_specialty ,Pediatrics ,Necrosis ,business.industry ,Anti tumour necrosis factor ,Internal medicine ,medicine ,In real life ,medicine.symptom ,National health service ,business - Published
- 2016
5. Safety, Tolerability, and Pharmacokinetic Effects of Thalidomide in Patients Infected with Human Immunodeficiency Virus: AIDS Clinical Trials Group 267
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Dawn Bell, David A. Wohl, Francesca T. Aweeka, Roger J. Pomerantz, Lawrence Fox, David Simpson, M.K. Holohan, Gilla Kaplan, Deborah Weng Cherng, John Spritzler, Hedy Teppler, John L. Schmitz, Wayne Malcolm Robinson, and Steven Thomas
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Adult ,Male ,Drug ,medicine.medical_specialty ,Anti-HIV Agents ,media_common.quotation_subject ,HIV Infections ,Placebo ,Gastroenterology ,Double-Blind Method ,Pharmacokinetics ,Internal medicine ,medicine ,Humans ,Immunology and Allergy ,Randomized Controlled Trials as Topic ,media_common ,business.industry ,CD4 Lymphocyte Count ,Thalidomide ,Bioavailability ,Clinical trial ,Infectious Diseases ,Tolerability ,Immunology ,Toxicity ,Female ,business ,medicine.drug - Abstract
Thalidomide is used to treat human immunodeficiency virus (HIV)-associated conditions, including aphthous ulcers and wasting syndrome. The safety, tolerability, and pharmacokinetics of a formulation of thalidomide with improved bioavailability in HIV-infected persons was examined in a placebo-controlled, dose-escalating phase 1 study. Subjects with CD4 cell counts of 200-500 cells/mm(3) were enrolled and randomized 3:1 in groups of 12 to receive 50, 100, or 150 mg of thalidomide or matching placebo. Two subjects who received 150 mg of drug and 2 subjects assigned placebo experienced dose-limiting toxicity. Concentrations of thalidomide in the blood increased with escalating dose, but the time to maximum concentration and clearance did not differ across dose cohorts. Previous suggestions of autoinduction of drug metabolism were not confirmed by this study. At the doses studied, thalidomide was tolerated well and had linear pharmacokinetics.
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- 2002
6. Continued lamivudine versus delavirdine in combination with indinavir and zidovudine or stavudine in lamivudine-experienced patients: results of Adult AIDS Clinical Trials Group protocol 370
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Dawn Bell, Joseph J. Eron, Jean Pierre Sommadossi, Ian C. Marschner, Victoria A. Johnson, Ana Martinez, Kenneth H. Fife, Edward P. Acosta, Robert L. Murphy, Daniel R. Kuritzkes, Roland L. Bassett, Kenneth Wood, and Carla Pettinelli
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Adult ,Male ,medicine.medical_specialty ,Time Factors ,Anti-HIV Agents ,Immunology ,Indinavir ,Gastroenterology ,Zidovudine ,Antiretroviral Therapy, Highly Active ,Internal medicine ,medicine ,Humans ,Immunology and Allergy ,Delavirdine ,Didanosine ,Acquired Immunodeficiency Syndrome ,Reverse-transcriptase inhibitor ,business.industry ,Stavudine ,virus diseases ,Lamivudine ,HIV Protease Inhibitors ,Viral Load ,Virology ,CD4 Lymphocyte Count ,Infectious Diseases ,Reverse Transcriptase Inhibitors ,Female ,business ,Viral load ,medicine.drug - Abstract
OBJECTIVE To compare the virologic activity of continued lamivudine (3TC) versus a switch to delavirdine (DLV) when initiating protease inhibitor therapy in nucleoside-experienced patients. DESIGN Randomized, open-label, multi-center study. SETTING Adult AIDS clinical trials units. PATIENTS Protease and non-nucleoside reverse transcriptase inhibitor-naive patients who had received 3TC plus zidovudine (ZDV), stavudine (d4T), or didanosine (ddl) for at least 24 weeks. INTERVENTIONS Patients with plasma HIV-1 RNA levels > 500 copies/ml who previously received d4T + 3TC or ddI + 3TC were randomized to ZDV + 3TC + indinavir (IDV) or ZDV + DLV + IDV. MAIN OUTCOME MEASURES Primary endpoints were the proportion of patients with plasma HIV-1 RNA levels < or = 200 copies/ml at 24 weeks, and occurrence of serious adverse events. The proportion of patients with plasma HIV-1 RNA levels < or = 200 copies/ml at week 48 was a secondary endpoint. RESULTS At week 24, 58% of subjects in the ZDV + 3TC + IDV arm and 73% in the ZDV + DLV + IDV arm had plasma HIV-1 RNA levels < or = 200 copies/ml (P = 0.29). At week 48, plasma HIV-1 RNA levels were < or = 200 copies/ml in 48% and 83%, respectively (P = 0.007). Rash and hyperbilirubinemia occurred more frequently in the DLV arm than in the 3TC arm. Steady-state plasma IDV levels were higher among patients in the DLV arm as compared with the 3TC arm. CONCLUSIONS Substituting DLV for 3TC when adding IDV improved virologic outcome in nucleoside-experienced patients. This result might be explained, in part, by the positive effect of DLV on IDV pharmacokinetics.
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- 2000
7. Reduced Mobilization of CD34+Stem Cells in Advanced Human Immunodeficiency Virus Type 1 Disease
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Thomas B. Campbell, Alan L. Landay, Daniel R. Ambruso, Roger J. Pomerantz, Robert T. Schooley, Simon Chiu, Malek Kamoun, Dawn Bell, Robbie Wong, Steven A. Miles, Jeannette Mladenovic, Robert W. Coombs, Lawrence Fox, Anne Sevin, and Janice Jacovini
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Adult ,Male ,Myeloid ,Filgrastim ,CD34 ,Antigens, CD34 ,HIV Infections ,Biology ,Cohort Studies ,T-Lymphocyte Subsets ,Precursor cell ,Granulocyte Colony-Stimulating Factor ,medicine ,Humans ,Immunology and Allergy ,Leukapheresis ,Hematopoietic Stem Cells ,Colony-stimulating factor ,Recombinant Proteins ,CD4 Lymphocyte Count ,Granulocyte colony-stimulating factor ,Infectious Diseases ,medicine.anatomical_structure ,DNA, Viral ,Immunology ,HIV-1 ,RNA, Viral ,Female ,Stem cell ,medicine.drug - Abstract
Granulocyte colony-stimulating factor (r-met Hu G-CSF; filgrastim; 10 microgram/kg/day for 7 days) was used to mobilize CD34+stem cells into the peripheral blood of human immunodeficiency virus type 1 (HIV-1)-infected individuals and a group of HIV-1-uninfected donors as a measure of immunologic reserve in HIV-1-infected people. G-CSF mobilized CD34+ cells of HIV-1-infected individuals with cell counts500 CD4+ cells/mm3, as well as in HIV-1-uninfected donors. In contrast, CD34 cell mobilization was significantly blunted in HIV-1-infected individuals with cell counts500 CD4+ cells/mm3 (200 cell days vs.650 cell days, P.0005, compared with the500 CD4+ cell cohort). At least 1.75x10(7) CD34 cells were harvested by leukapheresis from patients in each study cohort. CD34+ cell viability and the ability to differentiate precursor cells into myeloid and erythroid progenitor cells were not affected by HIV-1 infection.
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- 2000
8. Lamivudine in combination with zidovudine, stavudine, or didanosine in patients with HIV-1 infection. A randomized, double-blind, placebo-controlled trial
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Kenneth Fife, Dawn Bell, Janine Maenza, Margaret A. Fischl, Roland L. Bassett, Ian C. Marschner, Joseph J. Eron, Victoria A. Johnson, Daniel R. Kuritzkes, Robert L. Murphy, Caria Pettinelli, Ken Wood, Mary E. Rosandich, and Jean Pierre Sommadossi
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medicine.medical_specialty ,Combination therapy ,business.industry ,Immunology ,Stavudine ,Placebo-controlled study ,Lamivudine ,Gastroenterology ,Surgery ,Clinical trial ,Zidovudine ,Infectious Diseases ,Internal medicine ,parasitic diseases ,Immunology and Allergy ,Medicine ,business ,Viral load ,Didanosine ,medicine.drug - Abstract
Objective: To study the antiviral activity of lamivudine (3TC) plus zidovudine (ZDV), didanosine (ddl), or stavudine (d4T). Design: Randomized, placebo-controlled, partially double-blinded multicenter study. Setting: Adult AIDS Clinical Trials Units. Patients: Treatment-naive HIV-infected adults with 200-600 x 10 6 CD4 T lymphocytes/l. Interventions: Patients were openly randomized to a d4T or a ddl limb, then randomized in a blinded manner to receive: d4T (80 mg/day), d4T plus 3TC (300 mg/day), or ZDV (600 mg/day) plus 3TC, with matching placebos; or ddl (400 mg/day), ddl plus 3TC (300 mg/day), or ZDV (600 mg/day) plus 3TC, with matching placebos. After 24 weeks 3TC was added for patients assigned to the monotherapy arms. Main outcome measure: The reduction in plasma HIV-1 RNA level at weeks 24 and 48. Results: Two hundred ninety-nine patients were enrolled. After 24 weeks the mean reduction in plasma HIV-1 RNA copies/ml from baseline was 0.49 log 10 (d4T monotherapy) versus 1.03 log 10 (d4T plus 3TC; P = 0.001), and 0.68 log 10 (ddl monotherapy) versus 0.82 log 10 (ddl plus 3TC; P > 0.22). After 48 weeks the mean reduction was 1.08 log 10 (D4T plus 3TC) versus 1.01 log 10 (ZDV plus 3TC) in the d4T limb (P = 0.66), and 0.94 log 10 (ddl plus 3TC) versus 0.88 log 10 (ZDV plus 3TC; P = 0.70) in the ddl limb. Conclusions: 3TC added significantly to the virologic effects of d4T, but not ddl, in treatment-naive patients. 3TC plus d4T produced virologic changes comparable to those of 3TC plus ZDV. These results support the use of 3TC with either ZDV or d4T as a component of initial combination antiretroviral therapy.
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- 1999
9. 252. Levels of Patient Satisfaction in a Nurse/Pharmacist-Led Dmard Counselling Clinic
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Lesley Wylie, Sharon Christy-Kilner, and Dawn Bell
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medicine.medical_specialty ,Patient satisfaction ,Rheumatology ,Nursing ,business.industry ,Family medicine ,Pharmacist ,medicine ,Pharmacology (medical) ,Customer satisfaction ,business - Published
- 2014
10. Two double-blinded, randomized, comparative trials of 4 human immunodeficiency virus type 1 (HIV-1) envelope vaccines in HIV-1-infected individuals across a spectrum of disease severity: AIDS Clinical Trials Groups 209 and 214
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James O. Kahn, Patrick Haslett, Martin S. Hirsch, Daniel R. Kuritzkes, Bruce D. Walker, Mary E. Rosandich, Ronald T. Mitsuyasu, M. Juliana McElrath, Robert T. Schooley, Elizabeth L. Cooney, Thomas C. Merigan, Simon Chiu, Gerald Friedland, Dawn Bell, Bin Zhang, David Chernoff, Gayle Jones, Ann C. Collier, Smriti K. Kundu, Thomas Twadell, Susan Plaeger, Cathie Spino, Nzeera Ketter, Patricia Uherova, Fred T. Valentine, and Victor DeGruttola
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AIDS Vaccines ,Male ,Cellular immunity ,Acquired Immunodeficiency Syndrome ,biology ,Immunogenicity ,biology.organism_classification ,Lymphocyte Activation ,Virology ,Virus ,Vaccination ,Infectious Diseases ,Immune system ,Double-Blind Method ,Viral Envelope Proteins ,Immunity ,Immunopathology ,Immunology ,Lentivirus ,Immunology and Allergy ,Humans ,RNA, Viral ,Female - Abstract
The potential role of human immunodeficiency virus type 1 (HIV-1)-specific immune responses in controlling viral replication in vivo has stimulated interest in enhancing virus-specific immunity by vaccinating infected individuals with HIV-1 or its components. These studies were undertaken to define patient populations most likely to respond to vaccination, with the induction of novel HIV-1-specific cellular immune responses, and to compare the safety and immunogenicity of several candidate recombinant HIV-1 envelope vaccines and adjuvants. New lymphoproliferative responses (LPRs) developed in30% of vaccine recipients. LPRs were elicited primarily in study participants with a CD4 cell count350 cells/mm(3) and were usually strain restricted. Responders tended to be more likely than nonresponders to have an undetectable level of HIV-1 RNA at baseline (P=.067). Induction of new cellular immune responses by HIV-1 envelope vaccines is a function of the immunologic stage of disease and baseline plasma HIV-1 RNA level and exhibits considerable vaccine strain specificity.
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- 2000
11. Exploring Inpatients' Experiences of Healing and Healing Spaces
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Lorissa MacAllister PhD, AIA, Dawn Bellanti MSN, CRNP, and Bonnie R. Sakallaris PhD, RN
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Medicine (General) ,R5-920 - Abstract
In order to understand a patient’s healing experience it is essential to understand the elements that they, the patient, believes contributed to their healing. Previous research has focused on symptom reducers or contributors through environment such as stress. A person’s experience of healing happens over time not instantaneous. Therefore, in this study, the interviews with patients happened after forty-eight hours of hospitalization. This mixed methods study describes the experiences of seventeen inpatients from two healthcare systems using a phenomenological approach combined with evidence based design evaluation methods to document the setting. The qualitative data was analyzed first for reoccurring themes then further explored and defined through quantitative environmental observations. The seventeen patients defined healing as “getting better/well.” Seventy three statements were recorded about contributors and detractors to healing in the physical environment. Three primary themes emerged from the data as positive influencers of a healing experience: being cared for, being comfortable and experiencing something familiar or like home. These results demonstrate that patients perceive their inpatient healing experience through a supported environment.
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- 2016
- Full Text
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12. Are Predictive Energy Expenditure Equations Accurate in Cirrhosis?
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Tannaz Eslamparast, Benjamin Vandermeer, Maitreyi Raman, Leah Gramlich, Vanessa Den Heyer, Dawn Belland, Mang Ma, and Puneeta Tandon
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indirect calorimetry ,predictive equations ,resting energy expenditure ,cirrhosis ,Nutrition. Foods and food supply ,TX341-641 - Abstract
Malnutrition is associated with significant morbidity and mortality in cirrhosis. An accurate nutrition prescription is an essential component of care, often estimated using time-efficient predictive equations. Our aim was to compare resting energy expenditure (REE) estimated using predictive equations (predicted REE, pREE) versus REE measured using gold-standard, indirect calorimetry (IC) (measured REE, mREE). We included full-text English language studies in adults with cirrhosis comparing pREE versus mREE. The mean differences across studies were pooled with RevMan 5.3 software. A total of 17 studies (1883 patients) were analyzed. The pooled cohort was comprised of 65% men with a mean age of 53 ± 7 years. Only 45% of predictive equations estimated energy requirements to within 90⁻110% of mREE using IC. Eighty-three percent of predictive equations underestimated and 28% overestimated energy needs by ±10%. When pooled, the mean difference between the mREE and pREE was lowest for the Harris⁻Benedict equation, with an underestimation of 54 (95% CI: 30⁻137) kcal/d. The pooled analysis was associated with significant heterogeneity (I2 = 94%). In conclusion, predictive equations calculating REE have limited accuracy in patients with cirrhosis, most commonly underestimating energy requirements and are associated with wide variations in individual comparative data.
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- 2019
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13. Electron microscopic localization of wheat striate mosaic virus in its leafhopper vector, Endria inimica
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Peter E. Lee, C. Dawn Bell, and Sue A. Omar
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Cell Nucleus ,Cytoplasm ,Insecta ,Mosaic virus ,viruses ,Biology ,biology.organism_classification ,Virology ,Virus ,Salivary Glands ,law.invention ,Plant Viruses ,Leafhopper ,law ,Mosaic Viruses ,Vector (epidemiology) ,Animals ,Electron microscope ,Endria inimica ,Electron microscopic ,Triticum - Abstract
Electron microscopy of thin sections of salivary glands from wheat striate mosaic virus (WSMV)-infected leafhoppers, Endria inimica (Say), showed for the first time the presence of rhabdovirus particles in the leafhopper vector. These virus particles looked similar to those that have been observed in WSMV-infected wheat. The virions were found in the nuclei of infected cells both in well-defined intranuclear inclusions and in spaces between the inner and outer nuclear membranes. Bundles of particles were also seen in the cytoplasm close to infected nuclei. No particles were found in leafhoppers reared on virus-free wheat.
- Published
- 1978
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