Search

Your search keyword '"Davydova, Yu. O."' showing total 21 results
Start Over Author "Davydova, Yu. O."
21 results on '"Davydova, Yu. O."'

5. Treatment outcomes for acute T-lymphoblastic leukemias/lymphomas: data from the ALL-2016 multicenter prospective randomized trial

Author

Aleshina, O. A., primary, Galtseva, I. V., additional, Kotova, E. S., additional, Isinova, G. I., additional, Obukhova, T. N., additional, Dvirnik, V. N., additional, Sudarikov, A. B., additional, Grishunina, M. E., additional, Samoilova, O. S., additional, Kaplanov, K. D., additional, Lapin, V. A., additional, Bondarenko, S. N., additional, Fokina, E. S., additional, Minaeva, N. V., additional, Konstantinova, T. S., additional, Sveshnikova, Yu. V., additional, Zinina, E. E., additional, Antipova, A. S., additional, Baranova, O. Yu., additional, Borisenkova, E. A., additional, Davydova, Yu. O., additional, Kapranov, N. M., additional, Kulikov, S. M., additional, Chabaeva, Yu. A., additional, Troitskaya, V. V., additional, and Parovichnikova, E. N., additional

Published
2023
Full Text
View/download PDF

6. Comparison of the treatment results in adult patients with acute Ph-negative lymphoblastic leukemia on protocols of the Russian multicenter studies ALL-2009 and ALL-2016

Author

Parovichnikova, E. N., primary, Aleshina, O. A., additional, Troitskaya, V. V., additional, Chabaeva, Yu. A., additional, Sokolov, A. N., additional, Isinova, G. A., additional, Kotova, E. S., additional, Akhmerzaeva, Z. H., additional, Klyasova, G. A., additional, Galtseva, I. V., additional, Davydova, Yu. O., additional, Kuzmina, L. A., additional, Bondarenko, S. N., additional, Baranova, O. Yu., additional, Antipova, A. S., additional, Samoilova, O. S., additional, Grishunina, M. E., additional, Kaplanov, K. D., additional, Kaporskaya, T. S., additional, Konstantinova, T. S., additional, Sveshnikova, Yu. V., additional, Borisenkova, E. A., additional, Fokina, E. S., additional, Minaeva, N. V., additional, Zinina, E. E., additional, Lapin, V. A., additional, Gribanova, E. O., additional, Zvonkov, E. E., additional, Dvirnyk, V. N., additional, Galstyan, G. M., additional, Obukhova, T. N., additional, Sudarikov, A. B., additional, and Kulikov, S. M., additional

Published
2022
Full Text
View/download PDF

10. Impact of graft-versus-host disease prophylaxis on immune reconstitution in patients after allogeneic hematopoietic stem cell transplantation

Author

Mikhaltsova, E. D., primary, Popova, N. N., additional, Drokov, M. Yu., additional, Kapranov, N. M., additional, Davydova, Yu. O., additional, Vasilieva, V. A., additional, Dubnyak, D. S., additional, Maslikova, U. V., additional, Galtseva, I. V., additional, Kuzmina, L. A., additional, Parovichnikova, E. N., additional, and Savchenko, V. G., additional

Published
2021
Full Text
View/download PDF

11. Comparison of polymerase chain reaction and flow cytometry for measuring telomere length of human leukocytes

Author

Galtseva, I. V., primary, Filipenko, M. L., additional, Davydova, Yu. O., additional, Luchkin, A. V., additional, Kapranov, N. M., additional, Kondratieva, Yu. A., additional, Subbotin, S. V., additional, Khrapov, E. A., additional, Nikiforova, K. A., additional, Fidarova, Z. T., additional, Gaponova, T. V., additional, Mendeleeva, L. P., additional, Mikhailova, E. A., additional, Parovichnikova, E. N., additional, and Savchenko, V. G., additional

Published
2021
Full Text
View/download PDF

13. Expression features of antigens involved in the formation of immunological synapse in splenic marginal zone lymphoma

Author

Badmazhapova, D. S., primary, Galtseva, I. V., additional, Zvonkov, E. E., additional, Davydova, Yu. O., additional, Kapranov, M. M., additional, Moiseeva, T. N., additional, Kovrigina, A. M., additional, Julhakyan, U. L., additional, Danishyan, K. I., additional, Sabirov, K. R., additional, Parovichnikova, E. N., additional, and Savchenko, V. G., additional

Published
2020
Full Text
View/download PDF

14. Multipotent mesenchymal stromal cells application for acute graft versus host disease treatment

Author

Kuzmina, L. A., primary, Petinati, N. A., additional, Vasilieva, V. A., additional, Dovydenko, M. V., additional, Drokov, M. Yu., additional, Davydova, Yu. O., additional, Kapranov, N. M., additional, Sats, N. V., additional, Chabaeva, Yu. A., additional, Kulikov, S. M., additional, Gaponova, T. V., additional, Drize, N. I., additional, Parovichnikova, E. N., additional, and Savchenko, V. G., additional

Published
2020
Full Text
View/download PDF

15. Subpopulations of mobilized hematopoietic stem cells in patients with hematological malignances and donors: expression of CD38, HLA-DR and CD143

Author

Kanaeva, M. L., primary, Galtseva, I. V., additional, Parovichnikova, E. N., additional, Davydova, Yu. O., additional, Gaponova, T. V., additional, Gribanova, E. O., additional, Balzhanova, Ya. V., additional, Kuzmina, L. A., additional, Troitskaya, V. V., additional, Kravchenko, S. K., additional, Zvonkov, E. E., additional, Mendeleeva, L. P., additional, and Savchenko, V. G., additional

Published
2019
Full Text
View/download PDF

17. EXPRESSION FEATURES OF ANTIGENS INVOLVED IN THE FORMATION OF IMMUNOLOGICAL SYNAPSE IN CHRONIC LYMPHOCYTIC LEUKEMIA

Author

Badmazhapova, D. S., primary, Galtseva, I. V., additional, Zvonkov, E. Е., additional, Davydova, Yu. O., additional, Kapranov, N. M., additional, Chernova, N. G., additional, Gabeeva, N. G., additional, Moiseeva, T. N., additional, Kovrigina, A. M., additional, Dvirnyk, V. N., additional, Dzhulakyan, U. L., additional, Parovichnikova, E. N., additional, and Savchenko, V. G., additional

Published
2018
Full Text
View/download PDF

18. Absolute numbers of peripheral blood CD34+ hematopoietic stem cells prior to a leukapheresis procedure as a parameter predicting the efficiency of stem cell collection

Author

Galtseva, I V, primary, Davydova, Yu O, additional, Gaponova, T V, additional, Kapranov, N M, additional, Kuzmina, L A, additional, Troitskaya, V V, additional, Gribanova, E O, additional, Kravchenko, S K, additional, Mangasarova, Ya K, additional, Zvonkov, E E, additional, Parovichnikova, E N, additional, Mendeleeva, L P, additional, and Savchenko, V G, additional

Published
2017
Full Text
View/download PDF

20. Comparison of polymerase chain reaction and flow cytometry for measuring telomere length of human leukocytes.

Author

Galtseva IV, Filipenko ML, Davydova YO, Luchkin AV, Kapranov NM, Kondratieva YA, Subbotin SV, Khrapov EA, Nikiforova KA, Fidarova ZT, Gaponova TV, Mendeleeva LP, Mikhailova EA, Parovichnikova EN, and Savchenko VG

Subjects
DNA, Flow Cytometry, Humans, In Situ Hybridization, Fluorescence, Leukocytes, Telomere genetics
Abstract

Telomere length can be measured by polymerase chain reaction (PCR), allowing to obtain the absolute length of telomeres (ALT) in base pair, and by flow cytometry, which can only estimate the relative telomere length. The aim of the study was to compare the results of the two methods and to develop an accurate and reliable way of converting the relative telomere length to absolute. The peripheral blood from 21 donors was analyzed. Measurement of leukocyte telomere length by flow cytometry was carried out using a commercial Telomere PNA Kit / FITC (Dako, Denmark) with two CytoFLEX flow cytometers (Beckman Coulter, China) and BD FACSCanto II (Becton Dickinson, USA), obtaining the molecular equivalent of fluorescence (MEF). To measure telomere length by real-time PCR, calibrators with a known number of telomeric repeats were prepared. Two quantitative PCRs were carried out: one for telomeric repeats, the other for determining the number of genome-equivalents of DNA, three times for each sample, which made it possible to calculate ALT. A strong direct relationship was found between the MEF obtained with BD FACSCanto II and CytoFLEX (r = 0.97). Analysis of PCR and flow cytometry results showed a significant correlation between ALT and MEF. We calculated the regression equations of ALT and MEF for CytoFLEX - y = 0.0043x (r = 0.84) and for BD FACSCanto II - y = 0.0051x (r = 0.82). Correlation analysis showed a high comparability of telomere lengths measured by two methods. The obtained regression equations allow converting the results of flow cytometry into absolute values, allowing the comparison of the results of different research groups and the use of this method in clinical trials., Competing Interests: The authors declare no conflict of interest.

Published
2021
Full Text
View/download PDF

21. [The dynamics of paroxysmal nocturnal hemoglobinuria clone in patients with aplastic anemia in process of immune suppressive therapy].

Author

Fidarova ZT, Mikhailova EA, Galtseva IV, Lugovskaya SA, Naumova EV, Troitskaya VV, Ustinova EN, Davydova YO, Kapranov NM, Abramova AV, Parovichnikova EN, and Savchenko VG

Subjects
Anemia, Aplastic complications, Anemia, Aplastic genetics, Erythrocytes metabolism, Erythrocytes pathology, Female, Glycosylphosphatidylinositols biosynthesis, Granulocytes metabolism, Granulocytes pathology, Hemoglobinuria, Paroxysmal complications, Hemoglobinuria, Paroxysmal genetics, Humans, Male, Monocytes metabolism, Monocytes pathology, Anemia, Aplastic blood, Flow Cytometry, Hemoglobinuria, Paroxysmal blood, Membrane Proteins genetics
Abstract

The implementation of principles of highly sensitive flow cytometry into diagnostic of paroxysmal nocturnal hemoglobinuria increased rate of detection of paroxysmal nocturnal hemoglobinuria clone in patients with aplastic anemia already at early stages of diagnosis establishment (up to 79%). However, detection of paroxysmal nocturnal hemoglobinuria clone attracts interest not only from point of view of progression in % of patients with aplastic anemia). The occurrence of paroxysmal nocturnal hemoglobinuria clone in patients with aplastic anemia can be accompanied by hidden disorders of haemopoesis with increasing risk in conditions of proliferative stress. Hence, it is necessary to monitor the given clone during all period of observation. The study is a prospective investigation analyzing dynamics of paroxysmal nocturnal hemoglobinuria clone in process of immune suppressive therapy applied to 44 patients with aplastic anemia. The mentioned clone was initially detected in 59.6% of patients. The median of observation amounted to 27 (9-48) months. Depending on size of granulocytic paroxysmal nocturnal hemoglobinuria clone patients were allocated in four conditional groups: group I - from 0.01% to 0.99% (n=11); group II - from 1% to 9.99% (n=8); group III - from10% to 49.9% (n=4); group IV - from 50% and more (n=5). In the course of study the differently directed dynamics of paroxysmal nocturnal hemoglobinuria clone was revealed. In 3 out of 11 patients from group I median of paroxysmal nocturnal hemoglobinuria clone increased from minor values (less than 1%) to 3.55%; at that in one patient occurred total elimination of paroxysmal nocturnal hemoglobinuria clone to 12th month of observation. The noticeable unidirectional dynamics was established in patients of group III: already to 3d month of observation, simultaneously with becoming of remission, median of size of paroxysmal nocturnal hemoglobinuria clone in group diminished from 22.9% (18.39%-24.77%) to 5.6% (1.5%-6.7%). Among patients of groups II and IV paroxysmal nocturnal hemoglobinuria clone remained stable. The development of hemolytic form of paroxysmal nocturnal hemoglobinuria was observed in all patients of group IV i.e. in 18% of patients with aplastic anemia with primarily detected paroxysmal nocturnal hemoglobinuria clone. In the process of observation, in 37% of patients with aplastic anemia without primarily detected paroxysmal nocturnal hemoglobinuria clone its occurrence and persistence (median - 0.34% (0.1%-6.2%)) was noticed. According to the results of study, alteration of sizes of paroxysmal nocturnal hemoglobinuria clone or its occurrence develop in case of response to ISP and, most probably, depend on advantage of growth in the process of repair of normal (GPI positive) or clonal (GPI negative) hemopoiesis. To acquire more reliable conclusions will be possible through development of techniques of molecular diagnostic simultaneously with dynamic observation of course of disease in the given patients.

Published
2016

Catalog

Books, media, physical & digital resources
See catalog results