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44 results on '"Davoust, Nathalie"'

1. NF-κB subunits RelA and c-Rel selectively control CD4+ T cell function in multiple sclerosis and cancer

Author

Lalle, Guilhem, primary, Lautraite, Raphaëlle, additional, Bouherrou, Khaled, additional, Plaschka, Maud, additional, Pignata, Aurora, additional, Voisin, Allison, additional, Twardowski, Julie, additional, Perrin-Niquet, Marlène, additional, Stéphan, Pierre, additional, Durget, Sarah, additional, Tonon, Laurie, additional, Ardin, Maude, additional, Degletagne, Cyril, additional, Viari, Alain, additional, Belgarbi Dutron, Laurence, additional, Davoust, Nathalie, additional, Postler, Thomas S., additional, Zhao, Jingyao, additional, Caux, Christophe, additional, Caramel, Julie, additional, Dalle, Stéphane, additional, Cassier, Philippe A., additional, Klein, Ulf, additional, Schmidt-Supprian, Marc, additional, Liblau, Roland, additional, Ghosh, Sankar, additional, and Grinberg-Bleyer, Yenkel, additional

Published
2024
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3. Keeping Cell Death Alive: An Introduction into the French Cell Death Research Network

Author

Ichim, Gabriel, primary, Gibert, Benjamin, additional, Adriouch, Sahil, additional, Brenner, Catherine, additional, Davoust, Nathalie, additional, Desagher, Solange, additional, Devos, David, additional, Dokudovskaya, Svetlana, additional, Dubrez, Laurence, additional, Estaquier, Jérôme, additional, Gillet, Germain, additional, Guénal, Isabelle, additional, Juin, Philippe P., additional, Kroemer, Guido, additional, Legembre, Patrick, additional, Levayer, Romain, additional, Manon, Stéphen, additional, Mehlen, Patrick, additional, Meurette, Olivier, additional, Micheau, Olivier, additional, Mignotte, Bernard, additional, Nguyen-Khac, Florence, additional, Popgeorgiev, Nikolay, additional, Poyet, Jean-Luc, additional, Priault, Muriel, additional, Ricci, Jean-Ehrland, additional, Riquet, Franck B., additional, Susin, Santos A., additional, Suzanne, Magali, additional, Vacher, Pierre, additional, Walter, Ludivine, additional, and Mollereau, Bertrand, additional

Published
2022
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4. Abnormal accumulation of lipid droplets in neurons induces the conversion of alpha-Synuclein to proteolytic resistant forms in a Drosophila model of Parkinson’s disease

Author

Girard, Victor, primary, Jollivet, Florence, additional, Knittelfelder, Oskar, additional, Celle, Marion, additional, Arsac, Jean-Noel, additional, Chatelain, Gilles, additional, Van den Brink, Daan M., additional, Baron, Thierry, additional, Shevchenko, Andrej, additional, Kühnlein, Ronald P., additional, Davoust, Nathalie, additional, and Mollereau, Bertrand, additional

Published
2021
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6. Abnormal accumulation of lipid droplets in neurons induces the conversion of alpha-Synuclein to proteolytic resistant forms in a Drosophila model of Parkinson's disease

Author

Girard, Victor, Jollivet, Florence, Knittelfelder, Oskar, Celle, Marion, Arsac, Jean-Noel, Chatelain, Gilles, Brink, Daan M. Van den, Davoust, Nathalie, Mollereau, Bertrand, Girard, Victor, Jollivet, Florence, Knittelfelder, Oskar, Celle, Marion, Arsac, Jean-Noel, Chatelain, Gilles, Brink, Daan M. Van den, Davoust, Nathalie, and Mollereau, Bertrand

Abstract

Contains fulltext : 246936.pdf (Publisher’s version ) (Open Access)

Published
2021

10. A non-canonical lipid droplet metabolism regulates the conversion of alpha-Synuclein to proteolytic resistant forms in neurons of a Drosophila model of Parkinson disease

Author

Girard, Victor, primary, Jollivet, Florence, additional, Knittelfelder, Oskar, additional, Arsac, Jean-Noel, additional, Chatelain, Gilles, additional, Van den Brink, Daan M., additional, Baron, Thierry, additional, Shevchenko, Andrej, additional, Davoust, Nathalie, additional, and Mollereau, Bertrand, additional

Published
2020
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12. Complement anaphylatoxin receptors on neurons: new tricks for old receptors?

Author

Nataf, Serge, Stahel, Philip F., Davoust, Nathalie, and Barnum, Scott R.

Subjects
Neurons -- Physiological aspects, Peptide hormones -- Receptors, Health, Psychology and mental health
Abstract

Activation of the complement system has been reported in a variety of inflammatory diseases and neurodegenerative processes of the CNS. Recent evidence indicates that complement proteins and receptors are synthesized on or by glial cells and, surprisingly, neurons. Among these proteins are the receptors for the chemotactic and anaphylactic peptides, C5a and C3a, which are the most-potent mediators of complement inflammatory functions. The functions of glial-cell C3a and C5a receptors (C3aR and C5aR) appear to be similar to immune-cell C3aRs and C5aRs. However, little is known about the roles these receptors might have on neurons. Indeed, when compared with glial cells, neurons display a distinct pattern of C3aR and C5aR expression, in either the normal or the inflamed CNS.These findings suggest unique functions for these receptors on neurons.

Published
1999

15. Flavivirus NS3 and NS5 proteins interaction network: a high-throughput yeast two-hybrid screen

Author

Canard Bruno, Coutard Bruno, Deloire Alexandre, Meyniel-Schicklin Laurène, Le Breton Marc, de Lamballerie Xavier, Andre Patrice, Rabourdin-Combe Chantal, Lotteau Vincent, and Davoust Nathalie

Subjects
Microbiology, QR1-502
Abstract

Abstract Background The genus Flavivirus encompasses more than 50 distinct species of arthropod-borne viruses, including several major human pathogens, such as West Nile virus, yellow fever virus, Japanese encephalitis virus and the four serotypes of dengue viruses (DENV type 1-4). Each year, flaviviruses cause more than 100 million infections worldwide, some of which lead to life-threatening conditions such as encephalitis or haemorrhagic fever. Among the viral proteins, NS3 and NS5 proteins constitute the major enzymatic components of the viral replication complex and are essential to the flavivirus life cycle. Results We report here the results of a high-throughput yeast two-hybrid screen to identify the interactions between human host proteins and the flavivirus NS3 and NS5 proteins. Using our screen results and literature curation, we performed a global analysis of the NS3 and NS5 cellular targets based on functional annotation with the Gene Ontology features. We finally created the first flavivirus NS3 and NS5 proteins interaction network and analysed the topological features of this network. Our proteome mapping screen identified 108 human proteins interacting with NS3 or NS5 proteins or both. The global analysis of the cellular targets revealed the enrichment of host proteins involved in RNA binding, transcription regulation, vesicular transport or innate immune response regulation. Conclusions We proposed that the selective disruption of these newly identified host/virus interactions could represent a novel and attractive therapeutic strategy in treating flavivirus infections. Our virus-host interaction map provides a basis to unravel fundamental processes about flavivirus subversion of the host replication machinery and/or immune defence strategy.

Published
2011
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16. Physiological and pathological roles of FATP-mediated lipid droplets in Drosophila and mice retina

Author

Van Den Brink, Daan M., primary, Cubizolle, Aurélie, additional, Chatelain, Gilles, additional, Davoust, Nathalie, additional, Girard, Victor, additional, Johansen, Simone, additional, Napoletano, Francesco, additional, Dourlen, Pierre, additional, Guillou, Laurent, additional, Angebault-Prouteau, Claire, additional, Bernoud-Hubac, Nathalie, additional, Guichardant, Michel, additional, Brabet, Philippe, additional, and Mollereau, Bertrand, additional

Published
2018
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17. Expression of fatty acid transport protein in retinal pigment cells promotes lipid droplet expansion and photoreceptor homeostasis

Author

Van Den Brink, Daan M, primary, Cubizolle, Aurélie, additional, Chatelain, Gilles, additional, Napoletano, Francesco, additional, Dourlen, Pierre, additional, Davoust, Nathalie, additional, Guillou, Laurent, additional, Angebault-Prouteau, Claire, additional, Bernoud-Hubac, Nathalie, additional, Guichardant, Michel, additional, Brabet, Philippe, additional, and Mollereau, Bertrand, additional

Published
2018
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23. The Interactomes of Influenza Virus NS1 and NS2 Proteins Identify New Host Factors and Provide Insights for ADAR1 Playing a Supportive Role in Virus Replication

Author

de Chassey, Benoît, primary, Aublin-Gex, Anne, additional, Ruggieri, Alessia, additional, Meyniel-Schicklin, Laurène, additional, Pradezynski, Fabrine, additional, Davoust, Nathalie, additional, Chantier, Thibault, additional, Tafforeau, Lionel, additional, Mangeot, Philippe-Emmanuel, additional, Ciancia, Claire, additional, Perrin-Cocon, Laure, additional, Bartenschlager, Ralf, additional, André, Patrice, additional, and Lotteau, Vincent, additional

Published
2013
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24. Inflammasome activation restrictsLegionella pneumophilareplication in primary microglial cells through flagellin detection

Author

Jamilloux, Yvan, primary, Pierini, Roberto, additional, Querenet, Mathieu, additional, Juruj, Carole, additional, Fauchais, Anne-Laure, additional, Jauberteau, Marie-Odile, additional, Jarraud, Sophie, additional, Lina, Gérard, additional, Etienne, Jérôme, additional, Roy, Craig R., additional, Henry, Thomas, additional, Davoust, Nathalie, additional, and Ader, Florence, additional

Published
2013
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27. The CB2 Cannabinoid Receptor Controls Myeloid Progenitor Trafficking

Author

Palazuelos, Javier, primary, Davoust, Nathalie, additional, Julien, Boris, additional, Hatterer, Eric, additional, Aguado, Tania, additional, Mechoulam, Raphael, additional, Benito, Cristina, additional, Romero, Julian, additional, Silva, Augusto, additional, Guzmán, Manuel, additional, Nataf, Serge, additional, and Galve-Roperh, Ismael, additional

Published
2008
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31. A Role for the Neuronal Protein Collapsin Response Mediator Protein 2 in T Lymphocyte Polarization and Migration

Author

Vincent, Peggy, primary, Collette, Yves, additional, Marignier, Romain, additional, Vuaillat, Carine, additional, Rogemond, Véronique, additional, Davoust, Nathalie, additional, Malcus, Christophe, additional, Cavagna, Sylvie, additional, Gessain, Antoine, additional, Machuca-Gayet, Irma, additional, Belin, Marie-Françoise, additional, Quach, Tam, additional, and Giraudon, Pascale, additional

Published
2005
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37. Expression of dengue virus NS3 protein in Drosophilaalters its susceptibility to infection

Author

Querenet, Matthieu, Danjoy, Marie-Laure, Mollereau, Bertrand, and Davoust, Nathalie

Abstract

We developed a Drosophilamodel in which the dengue virus NS3 protein is expressed in a tissue specific and inducible manner. Dengue virus NS3 is a multifunctional protein playing a major role during viral replication. Both protease and helicase domains of NS3 are interacting with human and insect host proteins including innate immune components of the host machinery. We characterized the NS3 transgenic flies showing that NS3 expression did not affect fly development. To further study the links between NS3 and the innate immune response, we challenge the flies with gram-positive and gram-negative bacteria. Interestingly, the Drosophilatransgenic flies expressing NS3 were more susceptible to bacterial infections than control flies. However ubiquitous or immune-specific NS3 expression affected neither the life span nor the response to a non-infectious stress of the flies. In conclusion, we generated a new in vivosystem to study the functional impact of DENV NS3 protein on the innate immune response.

Published
2015
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38. The CB2 Cannabinoid Receptor Controls Myeloid Progenitor Trafficking: INVOLVEMENT IN THE PATHOGENESIS OF AN ANIMAL MODEL OF MULTIPLE SCLEROSIS.

Author

Palazuelos, Javier, Davoust, Nathalie, Julien, Boris, Hatterer, Eric, Aguado, Tania, Mechouiam, Raphael, Benito, Cristina, Romero, Julian, Silva, Augusto, Guzmán, Manuel, Nataf, Serge, and Galve-Roperh, Ismael

Subjects
*CANNABINOIDS, *MULTIPLE sclerosis, *LYMPHOCYTES, *PATHOLOGY, *ENCEPHALOMYELITIS, *SPINAL cord, *CHEMOKINES, *AXONAL transport, *BONE marrow, *INTERLEUKINS, *CELLS, *MICE
Abstract

Cannabinoids are potential agents for the development of therapeutic strategies against multiple sclerosis. Here we analyzed the role of the peripheral CB2 cannabinoid receptor in the control of myeloid progenitor cell trafficking toward the inflamed spinal cord and their contribution to microglial activation in an animal model of multiple sclerosis (experimental autoimmune encephalomyelitis, EAE). CB2 receptor knock-out mice showed an exacerbated clinical score of the disease when compared with their wild-type littermates, and this occurred in concert with extended axonal loss, T-lymphocyte (CD4+) infiltration, and microglial (CD11b+) activation. Immature bone marrow-derived CD34+ myeloid progenitor cells, which play a role in neuroinflammatory pathologies, were shown to express CB2 receptors and to be abundantly recruited toward the spinal cords of CB2 knock-out EAE mice. Bone marrow-derived cell transfer experiments further evidenced the increased contribution of these cells to microglial replenishment in the spinal cords of CB2-deficient animals. In line with these observations, selective pharmacological CB2 activation markedly reduced EAE symptoms, axonal loss, and microglial activation. CB2 receptor manipulation altered the expression pattern of different chemokines (CCL2, CCL3, CCL5) and their receptors (CCR1, CCR2), thus providing a mechanistic explanation for its role in myeloid progenitor recruitment during neuroinflammation. These findings demonstrate the protective role of CB2 receptors in EAE pathology; provide evidence for a new site of CB2 receptor action, namely the targeting of myeloid progenitor trafficking and its contribution to microglial activation; and support the potential use of non-psychoactive CB2 agonists in therapeutic strategies for multiple sclerosis and other neuroinflammatory disorders. [ABSTRACT FROM AUTHOR]

Published
2008
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42. Physiological and pathological roles of FATP-mediated lipid droplets in Drosophila and mice retina

Author

Michel Guichardant, Laurent Guillou, Victor Girard, Bertrand Mollereau, Nathalie Bernoud-Hubac, Aurélie Cubizolle, Daan M. Van Den Brink, Claire Angebault-Prouteau, Pierre Dourlen, Gilles Chatelain, Philippe Brabet, Francesco Napoletano, Simone Johansen, Nathalie Davoust, Laboratoire de biologie et modélisation de la cellule (LBMC UMR 5239), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), BioSciences Lyon-Gerland (BLG), École normale supérieure - Lyon (ENS Lyon)-Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut des Neurosciences de Montpellier - Déficits sensoriels et moteurs (INM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Department of Life Sciences, Trieste, University of Trieste, Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP), Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National de la Recherche Agronomique (INRA), French National Research Agency ANR-12-BSV1-0019-02, Association Francaise contre les Myopathies, a European Union's Seventh Framework Programme/AIRC (Associazione Italiana per la Ricerca sul cancro) Reintegration Grant, Bloomington Drosophila Stock Center NIH P40OD018537, CarMeN, laboratoire, Institut des Neurosciences de Montpellier (INM), Università degli studi di Trieste = University of Trieste, Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM), Van Den Brink, Daan M., Cubizolle, Aurélie, Chatelain, Gille, Davoust, Nathalie, Girard, Victor, Johansen, Simone, Napoletano, Francesco, Dourlen, Pierre, Guillou, Laurent, Angebault-Prouteau, Claire, Bernoud-Hubac, Nathalie, Guichardant, Michel, Brabet, Philippe, Mollereau, Bertrand, École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), École normale supérieure de Lyon (ENS de Lyon)-Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-École normale supérieure - Lyon (ENS Lyon)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hospices Civils de Lyon (HCL)

Subjects
Pigments, Aging, Sensory Receptors, Ecology, Evolution, Behavior and Systematics, Molecular Biology, Genetics, Genetics (clinical), Cancer Research, Social Sciences, Biochemistry, Mice, 0302 clinical medicine, Animal Cells, acyltransferase, Psychology, Energy-Producing Organelles, Neurons, Genetics & Heredity, Drosophila Melanogaster, Neurodegeneration, Eukaryota, Fatty Acid Transport Proteins, Lipids, Cell biology, drosophile, [SDV] Life Sciences [q-bio], Physical Sciences, gouttelette lipidique, Cellular Types, Cellular Structures and Organelles, photoreceptor differentiation, Visual phototransduction, Evolution, Ocular Anatomy, Materials Science, Retina, 03 medical and health sciences, Genetic, Vesicles, Materials by Attribute, Organisms, Biology and Life Sciences, Lipid Droplets, Lipid Metabolism, medicine.disease, Invertebrates, Ecology, Evolution, Behavior and Systematic, Mice, Inbred C57BL, 030104 developmental biology, age, Eyes, Reactive Oxygen Species, 030217 neurology & neurosurgery, Neuroscience, Photoreceptors, 0301 basic medicine, [SDV]Life Sciences [q-bio], Mitochondrion, souris, medicine.disease_cause, retine, Animals, Genetically Modified, Lipid droplet, Medicine and Health Sciences, Drosophila Proteins, Ecology, neurodegeneration, Animal Models, Mitochondria, Insects, medicine.anatomical_structure, Experimental Organism Systems, Drosophila, Sensory Perception, Anatomy, Research Article, Signal Transduction, Programmed cell death, Arthropoda, lcsh:QH426-470, Bioenergetics, Biology, Research and Analysis Methods, visual cycle, storage, Model Organisms, Behavior and Systematics, Ocular System, Coenzyme A Ligases, medicine, Animals, programmed cell-death, disease, acid transport proteins, Afferent Neurons, Lipid metabolism, Cell Biology, pigment epithelium, Oxidative Stress, lcsh:Genetics, rôle physiologique, Cellular Neuroscience, sense organs, Energy Metabolism, Head, Oxidative stress
Abstract

Increasing evidence suggests that dysregulation of lipid metabolism is associated with neurodegeneration in retinal diseases such as age-related macular degeneration and in brain disorders such as Alzheimer’s and Parkinson’s diseases. Lipid storage organelles (lipid droplets, LDs), accumulate in many cell types in response to stress, and it is now clear that LDs function not only as lipid stores but also as dynamic regulators of the stress response. However, whether these LDs are always protective or can also be deleterious to the cell is unknown. Here, we investigated the consequences of LD accumulation on retinal cell homeostasis under physiological and stress conditions in Drosophila and in mice. In wild-type Drosophila, we show that dFatp is required and sufficient for expansion of LD size in retinal pigment cells (RPCs) and that LDs in RPCs are required for photoreceptor survival during aging. Similarly, in mice, LD accumulation induced by RPC-specific expression of human FATP1 was non-toxic and promoted mitochondrial energy metabolism in RPCs and non-autonomously in photoreceptor cells. In contrast, the inhibition of LD accumulation by dFatp knockdown suppressed neurodegeneration in Aats-metFB Drosophila mutants, which carry elevated levels of reactive oxygen species (ROS). This suggests that abnormal turnover of LD may be toxic for photoreceptors cells of the retina under oxidative stress. Collectively, these findings indicate that FATP-mediated LD formation in RPCs promotes RPC and neuronal homeostasis under physiological conditions but could be deleterious for the photoreceptors under pathological conditions., Author summary Lipids are major cell constituents and are present in the membranes, as free lipids in the cytoplasm, or stored in vesicles called lipid droplets (LDs). Under conditions of stress, lipids stored in LDs can be released to serve as substrates for energy metabolism by mitochondria. However, lipid storage is dysregulated in many degenerative disorders such as age-related macular degeneration, Parkinson’s and Alzheimer’s diseases. Thus, it is unclear whether accumulation of LDs is protective or toxic for neuronal cells. To address this question, we examined the consequences of removal or enforced LD accumulation on the health of retinal cells in flies and mice. Like humans, fly and mouse retinas contain retinal pigment cells (RPC) that support the functions of neighboring photoreceptor cells. We found that overexpression of the fatty acid transport protein (FATP) in RPCs induced accumulation of LDs in both transgenic flies and mice. Moreover, LD accumulation in RPCs was not harmful for juxtaposed photoreceptors during aging, but was toxic under stress conditions. We propose that lipid storage promotes cellular communication that affects photoreceptor health.

Published
2018

43. [MiRNAs: new actors in the physiopathology of multiple sclerosis].

Author

Jagot F and Davoust N

Subjects
Animals, Central Nervous System immunology, Central Nervous System pathology, Disease Models, Animal, Encephalomyelitis, Autoimmune, Experimental genetics, Encephalomyelitis, Autoimmune, Experimental immunology, Encephalomyelitis, Autoimmune, Experimental pathology, Humans, Macrophages physiology, Multiple Sclerosis immunology, Multiple Sclerosis pathology, Th1 Cells physiology, Th17 Cells physiology, MicroRNAs physiology, Multiple Sclerosis genetics
Abstract

Multiple sclerosis (MS) is an auto-immune demyelinating disorder characterized by a chronic neuro-inflammatory process associated with an infiltration of the central nervous system (CNS) by autoreactive lymphocytes. The etiology of the disease remains unclear but the recent discovery of a dysregulated miRNA network in both cells and extracellular fluids of MS patients has brought new insights on the pathophysiological mechanisms involved in this disorder. miRNAs can induce a T cell polarization towards a pathological Th17 or Th1 phenotype and a deleterious activation of microglia, the CNS-resident macrophages. We provide here a review of the most recent data regarding miRNA dysregulation and pathophysiological roles in MS patients and in the animal model of MS, EAE (experimental autoimmune encephalomyelitis). Moreover, we discuss the putative clinical value of miRNAs as a novel biomarker and diagnostic tool for MS., (© 2017 médecine/sciences – Inserm.)

Published
2017
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44. Magnetic resonance imaging (MRI) of inflammation in stroke.

Author

Wiart M, Davoust N, Pialat JB, Berthezène Y, and Nighoghossian N

Subjects
Animals, Brain Ischemia metabolism, Brain Ischemia pathology, Brain Ischemia therapy, Cerebrum diagnostic imaging, Cerebrum metabolism, Cerebrum pathology, Disease Models, Animal, Inflammation diagnostic imaging, Inflammation genetics, Inflammation metabolism, Inflammation therapy, Macrophages metabolism, Macrophages pathology, Mice, Mice, Knockout, PPAR alpha genetics, PPAR alpha metabolism, PPAR-beta genetics, PPAR-beta metabolism, Radiography, Stroke genetics, Stroke metabolism, Stroke pathology, Stroke therapy, Brain Ischemia diagnostic imaging, Contrast Media pharmacology, Ferric Compounds pharmacology, Magnetic Resonance Imaging, Nanoparticles, Stroke diagnostic imaging
Abstract

Magnetic resonance imaging (MRI) of inflammation is based on the in vivo magnetic labelling of macrophages, the most abundant cells involved in the post-ischemic inflammatory response, by nanoparticles of iron oxides. Such approach has been successfully applied to study experimental rodent models of focal cerebral ischemia and has proved feasible in pioneer clinical studies. Despite current limitations, MRI of inflammation may become an important tool for the investigation of novel ischemic stroke therapeutics targeted at inflammation.

Published
2007
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