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4. Impact of the enfuvirtide resistance mutation N43D and the associated baseline polymorphism E137K on peptide sensitivity and six-helix bundle structure

Author

Xuefang, Bai, Wilson, Karen L., Seedorff, Jennifer E., Ahrens, Douglas, Green, Justin, Davison, Donna K., Lei Jin, Stanfield-Oakley, Sherry A., Mosier, Sarah M., Melby, Thomas E., Cammack, Nick, Zhongmin Wang, Greenberg, Michael L., and Dwyer, John J.

Subjects
Enfuvirtide -- Research, HIV (Viruses) -- Genetic aspects, Mutation (Biology) -- Research, Peptides -- Research, Biological sciences, Chemistry
Abstract

The detailed studies of the mechanism by which resistance mutations decrease sensitivity to enfuvirtide (ENF), the first human immunodeficiency virus type 1 (HIV 1) fusion inhibitor peptides and alter six-helix bundle structure are reported. The data obtained for a framework to understand the impact of resistance mutations on viral fitness and pathogenesis and provide a pathway for the development of new fusion inhibitor peptides.

Published
2008

5. Impact of the Enfuvirtide Resistance Mutation N43D and the Associated Baseline Polymorphism E137K on Peptide Sensitivity and Six-Helix Bundle Structure

Author

Bai, Xuefang, primary, Wilson, Karen L., additional, Seedorff, Jennifer E., additional, Ahrens, Douglas, additional, Green, Justin, additional, Davison, Donna K., additional, Jin, Lei, additional, Stanfield-Oakley, Sherry A., additional, Mosier, Sarah M., additional, Melby, Thomas E., additional, Cammack, Nick, additional, Wang, Zhongmin, additional, Greenberg, Michael L., additional, and Dwyer, John J., additional

Published
2008
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