1. Glycemic Control, Cognitive Aging, and Impairment Among Diverse Hispanic/Latino Individuals: Study of Latinos– Investigation of Neurocognitive Aging (Hispanic Community Health Study/Study of Latinos)
- Author
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González, Hector M, Tarraf, Wassim, Stickel, Ariana M, Morlett, Alejandra, González, Kevin A, Ramos, Alberto R, Rundek, Tatjana, Gallo, Linda C, Talavera, Gregory A, Daviglus, Martha L, Lipton, Richard B, Isasi, Carmen, Lamar, Melissa, Zeng, Donglin, and DeCarli, Charles
- Subjects
Public Health ,Health Sciences ,Mental Health ,Acquired Cognitive Impairment ,Clinical Research ,Minority Health ,Brain Disorders ,Prevention ,Alzheimer's Disease ,Behavioral and Social Science ,Basic Behavioral and Social Science ,Dementia ,Aging ,Neurodegenerative ,Diabetes ,Neurosciences ,Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) ,Mental health ,Good Health and Well Being ,Humans ,Hispanic or Latino ,Female ,Middle Aged ,Male ,Cognitive Dysfunction ,Aged ,Prospective Studies ,Glycemic Control ,Cognitive Aging ,Blood Glucose ,Glycated Hemoglobin - Abstract
ObjectiveHispanic/Latino individuals in the U.S. have the highest prevalence of undiagnosed and untreated diabetes and are at increased risk for cognitive impairment. In this study, we examine glycemic control in relation to cognitive aging and impairment in a large prospective cohort of middle-aged and older Hispanic/Latino individuals of diverse heritages.Research design and methodsStudy of Latinos-Investigation of Neurocognitive Aging (SOL-INCA) is a Hispanic Community Health Study/Study of Latinos (HCHS/SOL) ancillary study. HCHS/SOL is a multisite (Bronx, NY; Chicago, IL; Miami, FL; and San Diego, CA), probability sampled prospective cohort study. SOL-INCA enrolled 6,377 diverse Hispanic/Latino individuals aged 50 years and older (2016-2018). The primary outcomes were cognitive function, 7-year cognitive decline, and mild cognitive impairment (MCI). The primary glycemia exposure variables were measured from fasting blood samples collected at HCHS/SOL visit 1 (2008-2011).ResultsVisit 1 mean age was 56.5 years ± 8.2 SD, and the average glycosylated hemoglobin A1C (HbA1c) was 6.12% (43.5 ± 14.6 mmol/mol). After covariate adjustment, higher HbA1c was associated with accelerated 7-year global (b = -0.045; 95% CI -0.070; -0.021; in z score units) and executive cognitive decline and a higher prevalence of MCI (odds ratio 1.20; 95% CI 1.11; 1.29).ConclusionsElevated HbA1c levels were associated with 7-year executive cognitive decline and increased MCI risk among diverse middle-aged and older Hispanic/Latino individuals. Our findings indicate that poor glycemic control in midlife may pose significant risks for cognitive decline and MCI later in life among Hispanic/Latino individuals of diverse heritages.
- Published
- 2024