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18 results on '"Davies, Michael N."'

1. Muscle-Liver Trafficking of BCAA-Derived Nitrogen Underlies Obesity-Related Glycine Depletion

Author

White, Phillip J., Lapworth, Amanda L., McGarrah, Robert W., Kwee, Lydia Coulter, Crown, Scott B., Ilkayeva, Olga, An, Jie, Carson, Matthew W., Christopher, Bridgette A., Ball, James R., Davies, Michael N., Kjalarsdottir, Lilja, George, Tabitha, Muehlbauer, Michael J., Bain, James R., Stevens, Robert D., Koves, Timothy R., Muoio, Deborah M., Brozinick, Joseph T., Gimeno, Ruth E., Brosnan, M. Julia, Rolph, Timothy P., Kraus, William E., Shah, Svati H., and Newgard, Christopher B.

Published
2020
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4. Data from Whole-Body Sleeping Beauty Mutagenesis Can Cause Penetrant Leukemia/Lymphoma and Rare High-Grade Glioma without Associated Embryonic Lethality

Author

Collier, Lara S., primary, Adams, David J., primary, Hackett, Christopher S., primary, Bendzick, Laura E., primary, Akagi, Keiko, primary, Davies, Michael N., primary, Diers, Miechaleen D., primary, Rodriguez, Fausto J., primary, Bender, Aaron M., primary, Tieu, Christina, primary, Matise, Ilze, primary, Dupuy, Adam J., primary, Copeland, Neal G., primary, Jenkins, Nancy A., primary, Hodgson, J. Graeme, primary, Weiss, William A., primary, Jenkins, Robert B., primary, and Largaespada, David A., primary

Published
2023
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5. Supplementary Table 3 from Whole-Body Sleeping Beauty Mutagenesis Can Cause Penetrant Leukemia/Lymphoma and Rare High-Grade Glioma without Associated Embryonic Lethality

Author

Collier, Lara S., primary, Adams, David J., primary, Hackett, Christopher S., primary, Bendzick, Laura E., primary, Akagi, Keiko, primary, Davies, Michael N., primary, Diers, Miechaleen D., primary, Rodriguez, Fausto J., primary, Bender, Aaron M., primary, Tieu, Christina, primary, Matise, Ilze, primary, Dupuy, Adam J., primary, Copeland, Neal G., primary, Jenkins, Nancy A., primary, Hodgson, J. Graeme, primary, Weiss, William A., primary, Jenkins, Robert B., primary, and Largaespada, David A., primary

Published
2023
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6. Supplementary Figure 2 from Whole-Body Sleeping Beauty Mutagenesis Can Cause Penetrant Leukemia/Lymphoma and Rare High-Grade Glioma without Associated Embryonic Lethality

Author

Collier, Lara S., primary, Adams, David J., primary, Hackett, Christopher S., primary, Bendzick, Laura E., primary, Akagi, Keiko, primary, Davies, Michael N., primary, Diers, Miechaleen D., primary, Rodriguez, Fausto J., primary, Bender, Aaron M., primary, Tieu, Christina, primary, Matise, Ilze, primary, Dupuy, Adam J., primary, Copeland, Neal G., primary, Jenkins, Nancy A., primary, Hodgson, J. Graeme, primary, Weiss, William A., primary, Jenkins, Robert B., primary, and Largaespada, David A., primary

Published
2023
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7. Supplementary Table 2 from Whole-Body Sleeping Beauty Mutagenesis Can Cause Penetrant Leukemia/Lymphoma and Rare High-Grade Glioma without Associated Embryonic Lethality

Author

Collier, Lara S., primary, Adams, David J., primary, Hackett, Christopher S., primary, Bendzick, Laura E., primary, Akagi, Keiko, primary, Davies, Michael N., primary, Diers, Miechaleen D., primary, Rodriguez, Fausto J., primary, Bender, Aaron M., primary, Tieu, Christina, primary, Matise, Ilze, primary, Dupuy, Adam J., primary, Copeland, Neal G., primary, Jenkins, Nancy A., primary, Hodgson, J. Graeme, primary, Weiss, William A., primary, Jenkins, Robert B., primary, and Largaespada, David A., primary

Published
2023
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8. Supplementary Table 1 from Whole-Body Sleeping Beauty Mutagenesis Can Cause Penetrant Leukemia/Lymphoma and Rare High-Grade Glioma without Associated Embryonic Lethality

Author

Collier, Lara S., primary, Adams, David J., primary, Hackett, Christopher S., primary, Bendzick, Laura E., primary, Akagi, Keiko, primary, Davies, Michael N., primary, Diers, Miechaleen D., primary, Rodriguez, Fausto J., primary, Bender, Aaron M., primary, Tieu, Christina, primary, Matise, Ilze, primary, Dupuy, Adam J., primary, Copeland, Neal G., primary, Jenkins, Nancy A., primary, Hodgson, J. Graeme, primary, Weiss, William A., primary, Jenkins, Robert B., primary, and Largaespada, David A., primary

Published
2023
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9. Supplementary Figure 1 from Whole-Body Sleeping Beauty Mutagenesis Can Cause Penetrant Leukemia/Lymphoma and Rare High-Grade Glioma without Associated Embryonic Lethality

Author

Collier, Lara S., primary, Adams, David J., primary, Hackett, Christopher S., primary, Bendzick, Laura E., primary, Akagi, Keiko, primary, Davies, Michael N., primary, Diers, Miechaleen D., primary, Rodriguez, Fausto J., primary, Bender, Aaron M., primary, Tieu, Christina, primary, Matise, Ilze, primary, Dupuy, Adam J., primary, Copeland, Neal G., primary, Jenkins, Nancy A., primary, Hodgson, J. Graeme, primary, Weiss, William A., primary, Jenkins, Robert B., primary, and Largaespada, David A., primary

Published
2023
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10. Supplementary Table 4 from Whole-Body Sleeping Beauty Mutagenesis Can Cause Penetrant Leukemia/Lymphoma and Rare High-Grade Glioma without Associated Embryonic Lethality

Author

Collier, Lara S., primary, Adams, David J., primary, Hackett, Christopher S., primary, Bendzick, Laura E., primary, Akagi, Keiko, primary, Davies, Michael N., primary, Diers, Miechaleen D., primary, Rodriguez, Fausto J., primary, Bender, Aaron M., primary, Tieu, Christina, primary, Matise, Ilze, primary, Dupuy, Adam J., primary, Copeland, Neal G., primary, Jenkins, Nancy A., primary, Hodgson, J. Graeme, primary, Weiss, William A., primary, Jenkins, Robert B., primary, and Largaespada, David A., primary

Published
2023
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11. Supplementary Figure 3 from Whole-Body Sleeping Beauty Mutagenesis Can Cause Penetrant Leukemia/Lymphoma and Rare High-Grade Glioma without Associated Embryonic Lethality

Author

Collier, Lara S., primary, Adams, David J., primary, Hackett, Christopher S., primary, Bendzick, Laura E., primary, Akagi, Keiko, primary, Davies, Michael N., primary, Diers, Miechaleen D., primary, Rodriguez, Fausto J., primary, Bender, Aaron M., primary, Tieu, Christina, primary, Matise, Ilze, primary, Dupuy, Adam J., primary, Copeland, Neal G., primary, Jenkins, Nancy A., primary, Hodgson, J. Graeme, primary, Weiss, William A., primary, Jenkins, Robert B., primary, and Largaespada, David A., primary

Published
2023
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12. Supplementary Figure 4 from Whole-Body Sleeping Beauty Mutagenesis Can Cause Penetrant Leukemia/Lymphoma and Rare High-Grade Glioma without Associated Embryonic Lethality

Author

Collier, Lara S., primary, Adams, David J., primary, Hackett, Christopher S., primary, Bendzick, Laura E., primary, Akagi, Keiko, primary, Davies, Michael N., primary, Diers, Miechaleen D., primary, Rodriguez, Fausto J., primary, Bender, Aaron M., primary, Tieu, Christina, primary, Matise, Ilze, primary, Dupuy, Adam J., primary, Copeland, Neal G., primary, Jenkins, Nancy A., primary, Hodgson, J. Graeme, primary, Weiss, William A., primary, Jenkins, Robert B., primary, and Largaespada, David A., primary

Published
2023
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15. Activation and repression of glucose-stimulated ChREBP requires the concerted action of multiple domains within the MondoA conserved region

Author

Davies, Michael N., O'Callaghan, Brennon L., and Towle, Howard C.

Subjects
Glucose metabolism -- Physiological aspects, Binding proteins -- Physiological aspects, Biological sciences
Abstract

Carbohydrate response element-binding protein (ChREBP) is a glucose-dependent transcription factor that stimulates the expression of glycolytic and lipogenic genes in mammals. Glucose regulation of ChREBP has been mapped to its conserved NHz-terminal region of 300 amino acids, designated the MondoA conserved region (MCR). Within the MCR, five domains (MCR1-5) have a particularly high level of conservation and are likely to be important for glucose regulation. We carded out a large-scale deletion and substitution mutational analysis of the MCR domain of ChREBP. This analysis revealed that MCRs 1-4 function in a concerted fashion to repress ChREBP activity in basal (nonstimulatory) conditions. Deletion of the entire MCR1-4 segment or the combination of four specific point mutations located across this region leads to a highly active, glucose-independent form of ChREBP. However, deletion of any individual MCR domain and the majority of point mutations throughout MCR1-4 rendered ChREBP inactive. These observations suggest that the MCR1-4 region interacts with an additional coregulatory factor required for activation. This possibility is supported by the observation that the MCR1-4 region can compete for activity with wild-type ChREBP in stimulatory conditions. In contrast, mutations in the MCR5 domain result in increased activity, suggesting that this domain may be the target of intramolecular repression in basal conditions. Thus, the MCR domains act in a complex and coordinated manner to regulate ChREBP activity in response to glucose. carbohydrate response element-binding protein; transcription; lipogenesis; glucose signaling doi: 10.1152/ajpendo.00349.2010.

Published
2010

16. Whole-Body Sleeping Beauty Mutagenesis Can Cause Penetrant Leukemia/Lymphoma and Rare High-Grade Glioma without Associated Embryonic Lethality

Author

Collier, Lara S., primary, Adams, David J., additional, Hackett, Christopher S., additional, Bendzick, Laura E., additional, Akagi, Keiko, additional, Davies, Michael N., additional, Diers, Miechaleen D., additional, Rodriguez, Fausto J., additional, Bender, Aaron M., additional, Tieu, Christina, additional, Matise, Ilze, additional, Dupuy, Adam J., additional, Copeland, Neal G., additional, Jenkins, Nancy A., additional, Hodgson, J. Graeme, additional, Weiss, William A., additional, Jenkins, Robert B., additional, and Largaespada, David A., additional

Published
2009
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18. Glucose Activation of Carbohydrate Response Element Binding Protein (ChREBP) Requires a Nuclear Event Independent of Nucleocytoplasmic Shuttling.

Author

Davies, Michael N., O'Callaghan, Brennon L., and Towle, Howard C

Subjects
*CARRIER proteins, *GLUCOSE, *MAMMALS, *CELL membranes, *GENES, *GENETIC mutation
Abstract

Carbohydrate Response Element Binding Protein (ChREBP) is a glucose-responsive transcription factor that activates genes involved in de novo lipogenesis in mammals. However, the molecular mechanism involved in ChREBP activation has not been elucidated. The conserved N-terminal region of ChREBP contains putative Nuclear Localization (NLS) and Nuclear Export (NES) signals, suggesting that nucleocytoplasmic shuttling plays a role in glucose regulation. To analyze cellular localization of ChREBP as a function of glucose, we used confocal microscopy to observe FLAG-tagged ChREBP in INS-1 cells, a glucose-responsive rat beta cell line. ChREBP is predominantly cytoplasmic under low and high glucose conditions; however addition of a nuclear export inhibitor Leptomycin B resulted in nuclear trapping of ChREBP independent of glucose. To test whether nuclear localization is sufficient for ChREBP activation, we mutated conserved residues in and around the NES. Mutating ChREBP at two residues within the NES led to nuclear accumulation of ChREBP, but surprisingly this mutation also blocked ChREBP activation. Additional mutations in the NES region of ChREBP identified forms that lost NES function, but retained glucose regulation. We conclude that 1) nucleocytoplasmic shuttling is not essential for glucose regulation of ChREBP and 2) that an unknown nuclear glucose-dependent event is required for activation. [ABSTRACT FROM AUTHOR]

Published
2007

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