Search

Your search keyword '"Davies, Jessica L."' showing total 10 results
Start Over Author "Davies, Jessica L."
10 results on '"Davies, Jessica L."'

1. Mouse fetal growth restriction through parental and fetal immune gene variation and intercellular communications cascade

Author

Kaur, Gurman, Porter, Caroline B. M., Ashenberg, Orr, Lee, Jack, Riesenfeld, Samantha J., Hofree, Matan, Aggelakopoulou, Maria, Subramanian, Ayshwarya, Kuttikkatte, Subita Balaram, Attfield, Kathrine E., Desel, Christiane A. E., Davies, Jessica L., Evans, Hayley G., Avraham-Davidi, Inbal, Nguyen, Lan T., Dionne, Danielle A., Neumann, Anna E., Jensen, Lise Torp, Barber, Thomas R., Soilleux, Elizabeth, Carrington, Mary, McVean, Gil, Rozenblatt-Rosen, Orit, Regev, Aviv, and Fugger, Lars

Published
2022
Full Text
View/download PDF

2. Therapeutically expanded human regulatory T-cells are super-suppressive due to HIF1A induced expression of CD73

Author

Jarvis, Lorna B., Rainbow, Daniel B., Coppard, Valerie, Howlett, Sarah K., Georgieva, Zoya, Davies, Jessica L., Mullay, Harpreet Kaur, Hester, Joanna, Ashmore, Tom, Van Den Bosch, Aletta, Grist, James T., Coles, Alasdair J., Mousa, Hani S., Pluchino, Stefano, Mahbubani, Krishnaa T., Griffin, Julian L., Saeb-Parsy, Kourosh, Issa, Fadi, Peruzzotti-Jametti, Luca, Wicker, Linda S., and Jones, Joanne L.

Published
2021
Full Text
View/download PDF

5. Parental-fetal interplay of immune genes leads to intrauterine growth restriction

Author

Kaur, Gurman, primary, Porter, Caroline B. M., additional, Ashenberg, Orr, additional, Lee, Jack, additional, Riesenfeld, Samantha J., additional, Hofree, Matan, additional, Aggelakopoulou, Maria, additional, Subramanian, Ayshwarya, additional, Kuttikkatte, Subita Balaram, additional, Attfield, Kathrine E., additional, Desel, Christiane A. E., additional, Davies, Jessica L., additional, Evans, Hayley G., additional, Avraham-Davidi, Inbal, additional, Nguyen, Lan T., additional, Dionne, Danielle A., additional, Neumann, Anna E., additional, Jensen, Lise Torp, additional, Barber, Thomas R., additional, Soilleux, Elizabeth, additional, Carrington, Mary, additional, McVean, Gil, additional, Rozenblatt-Rosen, Orit, additional, Regev, Aviv, additional, and Fugger, Lars, additional

Published
2021
Full Text
View/download PDF

6. An integrated platform to systematically identify causal variants and genes for polygenic human traits

Author

Downes, Damien J., primary, Schwessinger, Ron, additional, Hill, Stephanie J., additional, Nussbaum, Lea, additional, Scott, Caroline, additional, Gosden, Matthew E., additional, Hirschfeld, Priscila P., additional, Telenius, Jelena M., additional, Eijsbouts, Chris Q., additional, McGowan, Simon J., additional, Cutler, Antony J., additional, Kerry, Jon, additional, Davies, Jessica L., additional, Dendrou, Calliope A., additional, Inshaw, Jamie R.J., additional, Larke, Martin S.C., additional, Marieke Oudelaar, A., additional, Bozhilov, Yavor, additional, King, Andrew J., additional, Brown, Richard C., additional, Suciu, Maria C., additional, Davies, James O.J., additional, Hublitz, Philip, additional, Fisher, Chris, additional, Kurita, Ryo, additional, Nakamura, Yukio, additional, Lunter, Gerton, additional, Taylor, Stephen, additional, Buckle, Veronica J., additional, Todd, John A., additional, Higgs, Douglas R., additional, and Hughes, Jim R., additional

Published
2019
Full Text
View/download PDF

8. Therapeutically expanded human regulatory T-cells are super-suppressive due to HIF1A induced expression of CD73

Author

Jarvis, Lorna B., Rainbow, Daniel B., Coppard, Valerie, Howlett, Sarah K., Georgieva, Zoya, Davies, Jessica L., Mullay, Harpreet Kaur, Hester, Joanna, Ashmore, Tom, Van Den Bosch, Aletta, Grist, James T., Coles, Alasdair J., Mousa, Hani S., Pluchino, Stefano, Mahbubani, Krishnaa T., Griffin, Julian L., Saeb-Parsy, Kourosh, Issa, Fadi, Peruzzotti-Jametti, Luca, Wicker, Linda S., and Jones, Joanne L.

Subjects
82, 82/58, 631/250/24/1529, article, hemic and immune systems, chemical and pharmacologic phenomena, 631/250/251/1574, 13/106, 3. Good health, 13/31, 13/1, 13/21, 631/250/1619/554/1898/1271, 38/39, 64/60, 631/250/24/1313
Abstract

The adoptive transfer of regulatory T-cells (Tregs) is a promising therapeutic approach in transplantation and autoimmunity. However, because large cell numbers are needed to achieve a therapeutic effect, in vitro expansion is required. By comparing their function, phenotype and transcriptomic profile against ex vivo Tregs, we demonstrate that expanded human Tregs switch their metabolism to aerobic glycolysis and show enhanced suppressive function through hypoxia-inducible factor 1-alpha (HIF1A) driven acquisition of CD73 expression. In conjunction with CD39, CD73 expression enables expanded Tregs to convert ATP to immunosuppressive adenosine. We conclude that for maximum therapeutic benefit, Treg expansion protocols should be optimised for CD39/CD73 co-expression.

9. Therapeutically expanded human regulatory T-cells are super-suppressive due to HIF1A induced expression of CD73

Author

Jarvis, Lorna B, Rainbow, Daniel B, Coppard, Valerie, Howlett, Sarah K, Georgieva, Zoya, Davies, Jessica L, Mullay, Harpreet Kaur, Hester, Joanna, Ashmore, Tom, Van Den Bosch, Aletta, Grist, James T, Coles, Alasdair J, Mousa, Hani S, Pluchino, Stefano, Mahbubani, Krishnaa T, Griffin, Julian L, Saeb-Parsy, Kourosh, Issa, Fadi, Peruzzotti-Jametti, Luca, Wicker, Linda S, and Jones, Joanne L

Subjects
Male, Gene Expression Regulation, Humans, hemic and immune systems, chemical and pharmacologic phenomena, Female, GPI-Linked Proteins, Hypoxia-Inducible Factor 1, alpha Subunit, 5'-Nucleotidase, T-Lymphocytes, Regulatory, 3. Good health
Abstract

The adoptive transfer of regulatory T-cells (Tregs) is a promising therapeutic approach in transplantation and autoimmunity. However, because large cell numbers are needed to achieve a therapeutic effect, in vitro expansion is required. By comparing their function, phenotype and transcriptomic profile against ex vivo Tregs, we demonstrate that expanded human Tregs switch their metabolism to aerobic glycolysis and show enhanced suppressive function through hypoxia-inducible factor 1-alpha (HIF1A) driven acquisition of CD73 expression. In conjunction with CD39, CD73 expression enables expanded Tregs to convert ATP to immunosuppressive adenosine. We conclude that for maximum therapeutic benefit, Treg expansion protocols should be optimised for CD39/CD73 co-expression.

10. Therapeutically expanded human regulatory T-cells are super-suppressive due to HIF1A induced expression of CD73

Author

Daniel B. Rainbow, Lorna B. Jarvis, Valerie Coppard, Hani S Mousa, Joanne L. Jones, Alasdair Coles, Zoya Georgieva, Fadi Issa, Kourosh Saeb-Parsy, Krishnaa T. Mahbubani, Stefano Pluchino, Tom Ashmore, Sarah Howlett, Julian L. Griffin, Luca Peruzzotti-Jametti, Linda S. Wicker, Aletta Van Den Bosch, Joanna Hester, Harpreet Kaur Mullay, James T. Grist, Jessica L. Davies, Jarvis, Lorna B [0000-0002-5760-0125], Rainbow, Daniel B [0000-0003-4931-3289], Davies, Jessica L [0000-0002-8888-1441], Hester, Joanna [0000-0002-7466-3849], Pluchino, Stefano [0000-0002-6267-9472], Mahbubani, Krishnaa T [0000-0002-1327-2334], Griffin, Julian L [0000-0003-1336-7744], Saeb-Parsy, Kourosh [0000-0002-0633-3696], Issa, Fadi [0000-0002-8279-7732], Wicker, Linda S [0000-0001-7771-0324], Jones, Joanne L [0000-0003-4974-1371], Apollo - University of Cambridge Repository, Mousa, Hani S [0000-0002-8327-7114], Jarvis, Lorna B. [0000-0002-5760-0125], Rainbow, Daniel B. [0000-0003-4931-3289], Davies, Jessica L. [0000-0002-8888-1441], Mahbubani, Krishnaa T. [0000-0002-1327-2334], Griffin, Julian L. [0000-0003-1336-7744], Wicker, Linda S. [0000-0001-7771-0324], and Jones, Joanne L. [0000-0003-4974-1371]

Subjects
Male, Adoptive cell transfer, Autoimmune diseases, Medicine (miscellaneous), medicine.disease_cause, T-Lymphocytes, Regulatory, Graft-versus-host disease, Autoimmunity, Transcriptome, 13/1, 0302 clinical medicine, Biology (General), 631/250/24/1313, 5'-Nucleotidase, 0303 health sciences, 631/250/24/1529, 631/250/251/1574, hemic and immune systems, Regulatory T cells, 3. Good health, 13/31, 030220 oncology & carcinogenesis, 631/250/1619/554/1898/1271, 38/39, 64/60, Female, General Agricultural and Biological Sciences, medicine.drug, QH301-705.5, 13/106, chemical and pharmacologic phenomena, Biology, GPI-Linked Proteins, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, 13/21, medicine, Humans, 030304 developmental biology, 82, 82/58, Hypoxia-Inducible Factor 1, alpha Subunit, Adenosine, Transplantation, HIF1A, Gene Expression Regulation, Anaerobic glycolysis, Cancer research, Ex vivo, Immunosuppression
Abstract

The adoptive transfer of regulatory T-cells (Tregs) is a promising therapeutic approach in transplantation and autoimmunity. However, because large cell numbers are needed to achieve a therapeutic effect, in vitro expansion is required. By comparing their function, phenotype and transcriptomic profile against ex vivo Tregs, we demonstrate that expanded human Tregs switch their metabolism to aerobic glycolysis and show enhanced suppressive function through hypoxia-inducible factor 1-alpha (HIF1A) driven acquisition of CD73 expression. In conjunction with CD39, CD73 expression enables expanded Tregs to convert ATP to immunosuppressive adenosine. We conclude that for maximum therapeutic benefit, Treg expansion protocols should be optimised for CD39/CD73 co-expression., Jarvis et al demonstrate that expanded human Tregs switch their metabolism to aerobic glycolysis and show enhanced suppressive function through hypoxia-inducible factor 1-alpha (HIF1A)-driven acquisition of CD73 expression, which along with CD39, enables expanded Tregs to convert ATP to immunosuppressive adenosine. Given this, the data suggests that Treg expansion protocols should be optimised for CD39/CD73 co-expression to enhance therapeutic potential.

Published
2020

Catalog

Books, media, physical & digital resources
See catalog results