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Much effort is devoted to measuring the nuclear symmetry energy through neutron star (NS) and nuclear observables. Since matter in the NS core may be non-hadronic, observables like radii and tidal deformability may not provide reliable constraints on properties of nucleonic matter. We demonstrate that coincident timing of a resonant shattering flare (RSF) and gravitational wave signal during binary NS inspiral probes the crust-core transition region and provides constraints on the symmetry energy comparable to terrestrial nuclear experiments. We show that nuclear masses, RSFs and measurements of NS radii and tidal deformabilities constrain different density ranges of the EOS, providing complementary probes., Comment: 7 pages, 3 figures submitted to PRL

The use of high flow nasal oxygen in the care of COVID-19-positive adult patients remains an area of contention. Early guidelines have discouraged the use of high flow nasal oxygen therapy in this setting due to the risk of viral spread to healthcare workers. However, there is the need to balance the relative risks of increased aerosol generation and virus transmission to healthcare workers against the role high flow nasal oxygen has in reducing hypoxaemia when managing the airway in high-risk patients during intubation or sedation procedures. The authors of this article undertook a narrative review to present results from several recent papers. Surrogate outcome studies suggest that the risk of high flow nasal oxygen in dispersing aerosol-sized particles is probably not as great as first perceived. Smoke laser-visualisation experiments and particle counter studies suggest that the generation and dispersion of bio-aerosols via high flow nasal oxygen with flow rates up to 60 l/min is similar to standard oxygen therapies. The risk appears to be similar to oxygen supplementation via a Hudson mask at 15 l/min and significantly less than low flow nasal prong oxygen 1–5 l/min, nasal continuous positive airway pressure with ill-fitting masks, bilevel positive airway pressure, or from a coughing patient. However, given the limited safety data, we recommend a cautious approach. For intubation in the COVID-positive or suspected COVID-positive patient we support the use of high flow nasal oxygen to extend time to desaturation in the at-risk groups, which include the morbidly obese, those with predicted difficult airways and patients with significant hypoxaemia, ensuring well-fitted high flow nasal oxygen prongs with staff wearing full personal protective equipment. For sedation cases, we support the use of high flow nasal oxygen when there is an elevated risk of hypoxaemia (e.g. bariatric endoscopy or prone-positioned procedures), but recommend securing the airway with a cuffed endotracheal tube for the longer duration procedures when theatre staff remain in close proximity to the upper airway, or considering the use of a surgical mask to reduce the risk of exhaled particle dispersion.

The behaviour of the nuclear symmetry energy near saturation density is important for our understanding of dense nuclear matter. This density dependence can be parameterised by the nuclear symmetry energy and its derivatives evaluated at nuclear saturation density. In this work we show that the core-crust interface mode of a neutron star is sensitive to these parameters, through the (density-weighted) shear-speed within the crust, which is in turn dependent on the symmetry energy profile of dense matter. We calculate the frequency at which the neutron star quadrupole ($\ell = 2$) crust-core interface mode must be driven by the tidal field of its binary partner to trigger a Resonant Shattering Flare (RSF). We demonstrate that coincident multimessenger timing of an RSF and gravitational wave chirp from a neutron star merger would enable us to place constraints on the symmetry energy parameters that are competitive with those from current nuclear experiments., Comment: 15 pages, 19 figures, accepted in MNRAS

Resonant Shattering flares (RSFs) are bursts of gamma-rays expected to be triggered by tidal resonance of a neutron star (NS) during binary inspiral. They are strongly dependent on the magnetic field strength at the surface of the NS. By modelling these flares as being the result of multiple colliding relativistic shells launched during the resonance window, we find that the prompt non-thermal gamma-ray emission may have luminosity up to a few $\times10^{48}\text{ erg/s}$, and that a broad-band afterglow could be produced. We compute the expected rates of detectable RSFs using the BPASS population synthesis code, with different assumptions about the evolution of surface magnetic field strengths before merger. We find the rate of detectable RSFs to be $\sim 0.0001-5$ per year for BHNS mergers and $\sim 0.0005-25$ per year for NSNS mergers, with the lower bound corresponding to surface-field decay consistent with magneto-thermal evolution in purely crustal fields, while the upper bounds are for systems which have longer-lived surface magnetic fields supported by flux frozen into the superconducting core. If some of the observed SGRB precursor flares are indeed RSFs, this suggests the presence of a longer-lived surface field for some fraction of the neutron star population, and that we could expect RSFs to be the most common detectable EM counterpart to GW detections of BHNS mergers. The non-detection of a RSF prior to GRB170817A provides an upper bound on the magnetic fields of the progenitor NSs of $B_{\rm surf}\sim 10^{13.5} \text{ G}$., Comment: 19 pages, 12 figures, final version accepted by MNRAS

BACKGROUND: There are well-documented treatment gaps in secondary prevention of coronary heart disease with a lack of clearly defined strategies to assist early physical activity after acute coronary syndromes (ACS). Smartphone technology may provide an innovative platform to close these gaps. OBJECTIVES: The primary goal of this study was to assess whether a smartphone-based, early cardiac rehabilitation program improved exercise capacity in patients with ACS. METHODS: A total of 206 patients with ACS across six tertiary Australian hospitals were included in this randomized controlled trial. Participants were randomized to usual care (UC; including referral to traditional cardiac rehabilitation), with or without an adjunctive smartphone-based cardiac rehabilitation program (S-CRP) upon hospital discharge. The primary endpoint was change in exercise capacity, measured by the change in 6-minute walk test distance at 8 weeks when compared to baseline, between groups. Secondary endpoints included uptake and adherence to cardiac rehabilitation, changes in cardiac risk factors, psychological well-being and quality of life status. RESULTS: Of the 168 patients with complete follow-up (age 56 ± 10 years; 16% females), 83 were in the S-CRP. At 8-week follow-up, the S-CRP group had a clinically significant improvement in 6-minute walk test distance (Δ117 ± 76 vs. Δ91 ± 110 m; P = 0.02). Patients in the S-CRP were more likely to participate (87% vs. 51%, P < 0.001) and adhere (72% vs. 22%, P < 0.001) to a cardiac rehabilitation program. Compared to UC, patients receiving S-CRP had similar smoking cessation rates, LDL-cholesterol levels, blood pressure reduction, depression, anxiety and quality of life measures (all P = NS). CONCLUSION: In patients with ACS, a S-CRP, as an adjunct to UC improved exercise capacity at 8 weeks in addition to participation and adherence to cardiac rehabilitation (Australian New Zealand Clinical Trials Registry; ACTRN12616000426482).

Background: The interim analysis of the multicentre New EPOC trial in patients with resectable colorectal liver metastasis showed a significant reduction in progression-free survival in patients allocated to cetuximab plus chemotherapy compared with those given chemotherapy alone. The focus of the present analysis was to assess the effect on overall survival. Methods: New EPOC was a multicentre, open-label, randomised, controlled, phase 3 trial. Adult patients (aged ≥18 years) with KRAS wild-type (codons 12, 13, and 61) resectable or suboptimally resectable colorectal liver metastases and a WHO performance status of 0–2 were randomly assigned (1:1) to receive chemotherapy with or without cetuximab before and after liver resection. Randomisation was done centrally with minimisation factors of surgical centre, poor prognosis cancer, and previous adjuvant treatment with oxaliplatin. Chemotherapy consisted of oxaliplatin 85 mg/m 2 administered intravenously over 2 h, l-folinic acid (175 mg flat dose administered intravenously over 2 h) or d,l-folinic acid (350 mg flat dose administered intravenously over 2 h), and fluorouracil bolus 400 mg/m 2 administered intravenously over 5 min, followed by a 46 h infusion of fluorouracil 2400 mg/m 2 repeated every 2 weeks (regimen one), or oxaliplatin 130 mg/m 2 administered intravenously over 2 h and oral capecitabine 1000 mg/m 2 twice daily on days 1–14 repeated every 3 weeks (regimen two). Patients who had received adjuvant oxaliplatin could receive irinotecan 180 mg/m 2 intravenously over 30 min with fluorouracil instead of oxaliplatin (regimen three). Cetuximab was given intravenously, 500 mg/m 2 every 2 weeks with regimen one and three or a loading dose of 400 mg/m 2 followed by a weekly infusion of 250 mg/m 2 with regimen two. The primary endpoint of progression-free survival was published previously. Secondary endpoints were overall survival, preoperative response, pathological resection status, and safety. Trial recruitment was halted prematurely on the advice of the Trial Steering Committee on Nov 1, 2012. All analyses (except safety) were done on the intention-to-treat population. Safety analyses included all randomly assigned patients. This trial is registered with ISRCTN, number 22944367. Findings: Between Feb 26, 2007, and Oct 12, 2012, 257 eligible patients were randomly assigned to chemotherapy with cetuximab (n=129) or without cetuximab (n=128). This analysis was carried out 5 years after the last patient was recruited, as defined in the protocol, at a median follow-up of 66·7 months (IQR 58·0–77·5). Median progression-free survival was 22·2 months (95% CI 18·3–26·8) in the chemotherapy alone group and 15·5 months (13·8–19·0) in the chemotherapy plus cetuximab group (hazard ratio [HR] 1·17, 95% CI 0·87–1·56; p=0·304). Median overall survival was 81·0 months (59·6 to not reached) in the chemotherapy alone group and 55·4 months (43·5–71·5) in the chemotherapy plus cetuximab group (HR 1·45, 1·02–2·05; p=0·036). There was no significant difference in the secondary outcomes of preoperative response or pathological resection status between groups. Five deaths might have been treatment-related (one in the chemotherapy alone group and four in the chemotherapy plus cetuximab group). The most common grade 3–4 adverse events reported were: neutrophil count decreased (26 [19%] of 134 in the chemotherapy alone group vs 21 [15%] of 137 in the chemotherapy plus cetuximab group), diarrhoea (13 [10%] vs 14 [10%]), skin rash (one [1%] vs 22 [16%]), thromboembolic events (ten [7%] vs 11 [8%]), lethargy (ten [7%] vs nine [7%]), oral mucositis (three [2%] vs 14 [10%]), vomiting (seven [5%] vs seven [5%]), peripheral neuropathy (eight [6%] vs five [4%]), and pain (six [4%] vs six [4%]). Interpretation: Although the addition of cetuximab to chemotherapy improves the overall survival in some studies in patients with advanced, inoperable metastatic disease, its use in the perioperative setting in patients with operable disease confers a significant disadvantage in terms of overall survival. Cetuximab should not be used in this setting. Funding: Cancer Research UK.

Background Results from large randomised controlled trials have shown that adding docetaxel to the standard of care (SOC) for men initiating hormone therapy for prostate cancer (PC) prolongs survival for those with metastatic disease and prolongs failure-free survival for those without. To date there has been no formal assessment of whether funding docetaxel in this setting represents an appropriate use of UK National Health Service (NHS) resources. Objective To assess whether administering docetaxel to men with PC starting long-term hormone therapy is cost-effective in a UK setting. Design, setting, and participants We modelled health outcomes and costs in the UK NHS using data collected within the STAMPEDE trial, which enrolled men with high-risk, locally advanced metastatic or recurrent PC starting first-line hormone therapy. Intervention SOC was hormone therapy for ≥2 yr and radiotherapy in some patients. Docetaxel (75 mg/m2) was administered alongside SOC for six three-weekly cycles. Outcome measurements and statistical analysis The model generated lifetime predictions of costs, changes in survival duration, quality-adjusted life years (QALYs), and incremental cost-effectiveness ratios (ICERs). Results and limitations The model predicted that docetaxel would extend survival (discounted quality-adjusted survival) by 0.89 yr (0.51) for metastatic PC and 0.78 yr (0.39) for nonmetastatic PC, and would be cost-effective in metastatic PC (ICER £5514/QALY vs SOC) and nonmetastatic PC (higher QALYs, lower costs vs SOC). Docetaxel remained cost-effective in nonmetastatic PC when the assumption of no survival advantage was modelled. Conclusions Docetaxel is cost-effective among patients with nonmetastatic and metastatic PC in a UK setting. Clinicians should consider whether the evidence is now sufficiently compelling to support docetaxel use in patients with nonmetastatic PC, as the opportunity to offer docetaxel at hormone therapy initiation will be missed for some patients by the time more mature survival data are available. Patient summary Starting docetaxel chemotherapy alongside hormone therapy represents a good use of UK National Health Service resources for patients with prostate cancer that is high risk or has spread to other parts of the body., Take Home Message Docetaxel is a cost-effective intervention in patients with metastatic and nonmetastatic prostate cancer starting hormone therapy. Clinicians and National Health Service funding bodies should consider whether the evidence is now sufficiently compelling to support initiating docetaxel in patients with nonmetastatic disease.

In this White Paper we present the potential of the Enhanced X-ray Timing and Polarimetry (eXTP) mission for determining the nature of dense matter; neutron star cores host an extreme density regime which cannot be replicated in a terrestrial laboratory. The tightest statistical constraints on the dense matter equation of state will come from pulse profile modelling of accretion-powered pulsars, burst oscillation sources, and rotation-powered pulsars. Additional constraints will derive from spin measurements, burst spectra, and properties of the accretion flows in the vicinity of the neutron star. Under development by an international Consortium led by the Institute of High Energy Physics of the Chinese Academy of Science, the eXTP mission is expected to be launched in the mid 2020s., Comment: Accepted for publication on Sci. China Phys. Mech. Astron. (2019)

In this paper we present geometry which has been designed to fit a layperson's description of a 'time machine'. It is a box which allows those within it to travel backwards and forwards through time and space, as interpreted by an external observer. Timelike observers travel within the interior of a 'bubble' of geometry which moves along a circular, acausal trajectory through spacetime. If certain timelike observers inside the bubble maintain a persistent acceleration, their worldlines will close.Our analysis includes a description of the causal structure of our spacetime, as well as a discussion of its physicality. The inclusion of such a bubble in a spacetime will render the background spacetime non-orientable, generating additional consistency constraints for formulations of the initial value problem. The spacetime geometry is geodesically incomplete, contains naked singularities, and requires exotic matter.

We calculate the electromagnetic signal of a gamma-ray flare coming from the surface of a neutron star shortly before merger with a black hole companion. Using a new version of the Monte Carlo radiation transport code Pandurata that incorporates dynamic spacetimes, we integrate photon geodesics from the neutron star surface until they reach a distant observer or are captured by the black hole. The gamma-ray light curve is modulated by a number of relativistic effects, including Doppler beaming and gravitational lensing. Because the photons originate from the inspiraling neutron star, the light curve closely resembles the corresponding gravitational waveform: a chirp signal characterized by a steadily increasing frequency and amplitude. We propose to search for these electromagnetic chirps using matched filtering algorithms similar to those used in LIGO data analysis., Comment: 13 pages, 5 figures, submitted to ApJ

Background: There are well-documented treatment gaps in secondary prevention of coronary heart disease and no clear guidelines to assist early physical activity after acute coronary syndromes (ACS). Smartphone technology may provide an innovative platform to close these gaps. This paper describes the study design of a randomized controlled trial assessing whether a smartphone-based secondary prevention program can facilitate early physical activity and improve cardiovascular health in patients with ACS. Methods: We have developed a multi-faceted, patient-centred smartphone-based secondary prevention program emphasizing early physical activity with a graduated walking program initiated on discharge from ACS admission. The program incorporates; physical activity tracking through the smartphone’s accelerometer with interactive feedback and goal setting; a dynamic dashboard to review and optimize cardiovascular risk factors; educational messages delivered twice weekly; a photographic food diary; pharmacotherapy review; and support through a short message service. The primary endpoint of the trial is change in exercise capacity, as measured by the change in six-minute walk test distance at 8-weeks when compared to baseline. Secondary endpoints include improvements in cardiovascular risk factor status, psychological well-being and quality of life, medication adherence, uptake of cardiac rehabilitation and re-hospitalizations. Discussion: This randomized controlled trial will use a smartphone-phone based secondary prevention program to emphasize early physical activity post-ACS. It will provide evidence regarding the feasibility and utility of this innovative platform in closing the treatment gaps in secondary prevention. Trial registration: The trial was retrospectively registered in the Australian New Zealand Clinical Trials Registry (ANZCTR) on April 4, 2016. The registration number is ACTRN12616000426482.

Following the faint gamma-ray burst, GRB 170817A, coincident with a gravitational wave-detected binary neutron star merger at d &sim, 40 Mpc, we consider the constraints on a local population of faint short duration GRBs (defined here broadly as T 90 &lt, 4 s). We review proposed low-redshift short-GRBs and consider statistical limits on a d ≲ 200 Mpc population using Swift/Burst Alert Telescope (BAT), Fermi/Gamma-ray Burst Monitor (GBM), and Compton Gamma-Ray Observatory (CGRO) Burst and Transient Source Experiment (BATSE) GRBs. Swift/BAT short-GRBs give an upper limit for the all-sky rate of &lt, 4 y &minus, 1 at d &lt, 200 Mpc, corresponding to &lt, 5% of SGRBs. Cross-correlation of selected CGRO/BATSE and Fermi/GBM GRBs with d &lt, 100 Mpc galaxy positions returns a weaker constraint of ≲ 12 y &minus, 1 . A separate search for correlations due to SGR giant flares in nearby ( d &lt, 11 Mpc) galaxies finds an upper limit of &lt, 3 y &minus, 1 . Our analysis suggests that GRB 170817A-like events are likely to be rare in existing SGRB catalogues. The best candidate for an analogue remains GRB 050906, where the Swift/BAT location was consistent with the galaxy IC 0327 at d &asymp, 132 Mpc. If binary neutron star merger rates are at the high end of current estimates, then our results imply that at most a few percent will be accompanied by detectable gamma-ray flashes in the forthcoming LIGO/Virgo science runs.

We study global non-axisymmetric oscillation modes trapped near the inner boundary of an accretion disc. Observations indicate that some of the quasi-periodic oscillations (QPOs) observed in the luminosities of accreting compact objects (neutron stars, black holes and white dwarfs) are produced in the inner-most regions of accretion discs or boundary layers. Two simple models are considered in this paper: The magnetosphere-disc model consists of a thin Keplerian disc in contact with a uniformly rotating magnetosphere with and low plasma density, while the star-disc model involves a Keplerian disc terminated at the stellar atomosphere with high density and small density scale height. We find that the interface modes at the magnetosphere-disc boundary are generally unstable due to Rayleigh-Taylor and/or Kelvin-Helmholtz instabilities. However, differential rotation of the disc tends to suppress Rayleigh-Taylor instability and a sufficiently high disc sound speed (or temperature) is needed to overcome this suppression and to attain net mode growth. On the other hand, Kelvin-Helmholtz instability may be active at low disc sound speeds. We also find that the interface modes trapped at the boundary between a thin disc and an unmagnetized star do not suffer Rayleigh-Taylor or Kelvin-Helmholtz instability, but can become unstable due to wave leakage to large disc radii and, for sufficiently steep disc density distributions, due to wave absorption at the corotation resonance in the disc. The non-axisymmetric interface modes studied in this paper may be relevant to the high-frequency QPOs observed in some X-ray binaries and in cataclysmic variables., Comment: 14 pages, 9 figures, submitted to MNRAS

Diskoseismic c-modes in accretion discs have been invoked to explain low-frequency variabilities observed in black-hole X-ray binaries. These modes are trapped in the inner-most region of the disc and have frequencies much lower than the rotation frequency at the disc inner radius. We show that because the trapped waves can tunnel through the evanescent barrier to the corotational wave zone, the c-modes are damped due to wave absorption at the corotation resonance. We calculate the corotational damping rates of various c-modes using the WKB approximation. The damping rate varies widely depending on the mode frequency, the black hole spin parameter and the disc sound speed, and is generally much less than 10% of the mode frequency. A sufficiently strong excitation mechanism is needed to overcome this corotational damping and make the mode observable., Comment: 10 pages, 5 figures, MNRAS in press

Urethral carcinoma is a rare malignancy, without validated treatment protocols. In particular, the role of chemotherapy remains poorly defined. In this Case Study, Nicholson and colleagues discuss a 48-year-old woman with a T4N0M0 tumor, who was successfully treated with neoadjuvant TIP (paclitaxel, ifosfamide, cisplatin) chemotherapy followed by consolidative chemoradiation therapy. Background A 48-year old woman presented to an emergency department with acute urinary retention necessitating suprapubic catheterization. Investigations Pelvic examination under anesthetic by both a urologist and gynecologist, biopsy of the urethral tumor and of the cervix, pathological analysis, MRI of the pelvis, CT of the chest, abdomen and pelvis. Diagnosis Poorly differentiated squamous cell carcinoma of the urethra, T4N0M0. Management The patient received two cycles of neoadjuvant TIP (paclitaxel, ifosfamide, cisplatin) chemotherapy, resulting in complete remission, followed by consolidative chemoradiation therapy (radiation therapy given with synchronous weekly cisplatin). She remained relapse-free 48 months after diagnosis, with normal voiding and sexual function.

Symplectic integrators are widely used for long-term integration of conservative astrophysical problems due to their ability to preserve the constants of motion; however, they cannot in general be applied in the presence of nonconservative interactions. In this Letter, we develop the "slimplectic" integrator, a new type of numerical integrator that shares many of the benefits of traditional symplectic integrators yet is applicable to general nonconservative systems. We utilize a fixed time-step variational integrator formalism applied to the principle of stationary nonconservative action developed in Galley, 2013; Galley, Tsang & Stein, 2014. As a result, the generalized momenta and energy (Noether current) evolutions are well-tracked. We discuss several example systems, including damped harmonic oscillators, Poynting-Robertson drag, and gravitational radiation reaction, by utilizing our new publicly available code to demonstrate the slimplectic integrator algorithm. Slimplectic integrators are well-suited for integrations of systems where nonconservative effects play an important role in the long-term dynamical evolution. As such they are particularly appropriate for cosmological or celestial N-body dynamics problems where nonconservative interactions, e.g. gas interactions or dissipative tides, can play an important role., 6 pages, 5 Figures; Accepted to ApJL; code repository at http://github.com/davtsang/slimplectic (typo fixed in repository URL)

We examine the effects of higher-order multipole contributions of rotating neutron star (NS) spacetimes on the propagation of corrugation (c-)modes within a thin accretion disk. We find that the Lense-Thirring precession frequency, which determines the propagation region of the low-frequency fundamental corrugation modes, can experience a turnover allowing for c-modes to become self-trapped for sufficiently high dimensionless spin $j$ and quadrupole rotational deformability $\alpha$. If such self-trapping c-modes can be detected, e.g. through phase-resolved spectroscopy of the iron line for a high-spin low-mass accreting neutron star, this could potentially constrain the spin-induced NS quadrupole and the NS equation of state., Comment: 6 pages, 4 figures, submitted to ApJL

Magnetars are neutron stars showing dramatic X-ray and soft $\gamma$-ray outbursting behaviour that is thought to be powered by intense internal magnetic fields. Like conventional young neutron stars in the form of radio pulsars, magnetars exhibit "glitches" during which angular momentum is believed to be transferred between the solid outer crust and the superfluid component of the inner crust. Hitherto, the several hundred observed glitches in radio pulsars and magnetars have involved a sudden spin-up of the star, due presumably to the interior superfluid rotating faster than the crust. Here we report on X-ray timing observations of the magnetar 1E 2259+586 which we show exhibited a clear "anti-glitch" -- a sudden spin down. We show that this event, like some previous magnetar spin-up glitches, was accompanied by multiple X-ray radiative changes and a significant spin-down rate change. This event, if of origin internal to the star, is unpredicted in models of neutron star spin-down and is suggestive of differential rotation in the neutron star, further supporting the need for a rethinking of glitch theory for all neutron stars.

Genistein is a soy isoflavone that has attracted much attention for its chemopreventive properties. Baicalein is a flavone found in Scutellaria species, and its structure is analogous to that of genistein. We examined the two flavones' antiestrogenicity by using a transient transfection model. Our results indicated that baicalein could suppress 17beta-estradiol-induced transactivation in cells expressing estrogen receptor alpha, whereas no antagonistic activity was seen in genistein. Cell death assay and flow cytometry analysis demonstrated that baicalein was a stronger apoptosis inducing agent than genistein. Considering all the criteria tested, baicalein could be a better chemopreventive agent than genistein.

Green tea cateachins (GTC). namely (-) epicatechin (EC), (-) epicatechin gallate (ECG), (-) epigallocatechin (EGC), and (-) epigallocatechin gallate (EGCG), have been studied extensively for their wide-ranging biological activities. The goal of the present study was to examine the stability of GTC as a mixture under various processing conditions. The stability study demonstrated that GTC was stable in water at room temperature. When it was brewed at 98 degrees C for 7 h, longjing GTC degraded by 20%. When longjing GTC and pure EGCG were autoclaved at 120 degrees C for 20 min, the epimerization of EGCG to (-) gallocatechin gallate (GCG) was observed. The relatively high amount of GCG found in some tea drinks was most likely the epimerization product of EGCG during autoclaving. If other ingredients were absent, the GTC in aqueous solutions was pH-sensitive: the lower the pH, the more stable the GTC during storage. When it was added into commercially available soft drinks or sucrose solutions containing citric acid and ascorbic acid, longjing GTC exhibited varying stability irrespective of low pH value. This suggested that other ingredients used in production of tea drinks might interact with GTC and affect its stability. When canned and bottled tea drinks are produced, stored, and transported, the degradation of GTC must be taken into consideration.

1. The aim of this study was to determine the epithelial changes of the conjunctiva and cornea up to 7 days after corneal debridement and the changes highlighted included (1) proliferation, (2) production of growth factor, (3) changes in calcium binding protein marker, (4) production of cytokine, and (5) maturity of the regeneration corneal epithelium.

Using reverse transcription-polymerase chain reaction (RT-PCR) technique, the levels of tumor necrosis factor receptors gene expression in C6 glioma cells upon induction with tumor necrosis factor-alpha (TNF-alpha) were analysed. In control cells, the level of mRNA for tumor necrosis factor receptor type II (TNF-R2; 75/80 kDa) was much lower than that of tumor necrosis factor receptor type I (TNF-R1; 55/60 kDa). Upon exposure to TNF-alpha, the TNF-R2 mRNA level was greatly increased, while the TNF-R1 mRNA level remained unchanged even after 48 h. The induction of TNF-R2 gene expression by TNF-alpha was dose-dependent and seemed to be unique to TNF-alpha, as IL-6 had no effect. Since TNF-R2 was reported to mediate mitogenic effect in many other cell types, it is likely that the reported proliferative effect of TNF-alpha on astrocytes and C6 glioma cells was mediated by this TNF receptor subtype.

Green tea catechins (GTCs), which include (−)-epicatechin (EC), (−)-epicatechin gallate (ECG), (−)-epigallocatechin (EGC) and (−)-epigallocatechin gallate (EGCG), possess a variety of biological activities. We have previously studied the effect of dietary GTCs as a mixture on membrane oxidation of red blood cells and found that GTCs were partially absorbed and detected in the blood of rats given an oral ingestion of 100 mg of GTCs. To explain the partial absorption of GTCs and their varying free-radical scavenging capacity at different pH, the present paper was to study further the pH stability of these GTC isomers because there is a sharp increase in pH from the acidic stomach to the slightly alkaline intestine. Longjing GTCs as a mixture in alkaline solutions (pH > 8) were extremely unstable and degraded almost completely in a few minutes, whereas in acidic solutions (pH < 4) they were very stable. For the pH between 4 and 8, the stability of GTCs was pH-dependent, i.e., the lower the pH, the greater th...

The effect of endothelin-3 (ET-3) on C-type natriuretic peptide (CNP)-induced guanosine 3',5'-cyclic monophosphate (cGMP) was examined in C6 glioma cells, CNP-induced cGMP formation was both time- and dose-dependent, with an EC50 value of about 10 nM. While ET-3 and phorbol 12-myristate 13-acetate (PMA) had no effect on basal cGMP production, both compounds were potent inhibitors of CNP-induced cGMP formation, with IC50 values of approximately 10 and 2 nM, respectively. Although protein kinase C (PKC) inhibitors had no effect on basal cGMP formation, Ro 31-8220, a PKC inhibitor, reversed the ET-3 inhibition on CNP-induced cGMP formation by 63% and that of PMA almost completely. Our findings suggest that stimulation of cGMP formation by CNP in C6 glioma cells is negatively modulated by PKC activation, and that the inhibitory action of ET-3 on CNP-stimulated cGMP formation is mediated partly by PKC.

I derive a fully analytic expression for the linear corotation torque to first order in eccentricity for planets in non-barotropic protoplanetary disks, taking into account the effect of disk entropy gradients. This torque formula is applicable to both the co-orbital corotation torque and the non co-orbital corotation torques -- for planets in orbits with non-zero eccentricity -- in disks where the thermal diffusivity and viscosity are sufficient to maintain linearity of these interactions. While the co-orbital corotation torque is important for migration of planets in Type I migration, the non co-orbital corotation torque plays an important role in the eccentricity evolution of giant planets that have opened gaps in the disk. The presence of an entropy gradient in the disk can significantly modify the corotation torque in both these cases., 10 pages, accepted by ApJ

Using a fast semi-analytic raytracing code, we study the variability of relativistically broadened iron lines due to discoseismic oscillations concentrated in the inner-most regions of accretion discs around black holes. The corrugation mode, or c-mode, is of particular interest as its natural frequency corresponds well to the ~0.1-15Hz range observed for low-frequency quasi-periodic oscillations (LFQPOs) for lower spins. Comparison of the oscillation phase dependent variability and QPO-phase stacked iron line observations will allow such discoseismic models to be confirmed or ruled out as a source of particular LFQPOs. The spectral range and frequency of the variability of the iron line due to corrugation modes can also potentially be used to constrain the black hole spin if observed with sufficient temporal and spectral resolution., 21 pages, 13 figures, accepted by MNRAS

We demonstrate that resonant shattering flares can occur during close passages of neutron stars in eccentric or hyperbolic encounters. We provide updated estimates for the rate of close encounters of compact objects in dense stellar environments, which we find are substantially lower than given in previous works. While such occurrences are rare, we show that shattering flares can provide a strong electromagnetic counterpart to the gravitational wave bursts expected from such encounters, allowing triggered searches for these events to occur., 9 pages, 3 figures, submitted to ApJ

We examine timing noise in both magnetars and regular pulsars, and find that there exists a component of the timing noise with strong magnetic field dependence above B ~ 10^{12.5} G. The dependence of the timing noise floor on the magnetic field is also reflected in the smallest observable glitch size. We find that magnetospheric torque variation cannot explain this component of timing noise. We calculate the moment of inertia of the magnetic field outside of a neutron star and show that this timing noise component may be due to variation of this moment of inertia, and could be evidence of rapid global magnetospheric variability., 5 pages, 3 figures, accepted by ApJL

The physical origin of high-frequency QPOs (HFQPOs) in black-hole X-ray binaries remains an enigma despite many years of detailed observational studies. Although there exists a number of models for HFQPOs, many of these are simply "notions" or "concepts" without actual calculation derived from fluid or disk physics. Future progress requires a combination of numerical simulations and semi-analytic studies to extract physical insights. We review recent works on global oscillation modes in black-hole accretion disks, and explain how, with the help of general relativistic effects, the energy stored in the disk differential rotation can be pumped into global spiral density modes in the disk, making these modes grow to large amplitudes under certain conditions ("corotational instability"). These modes are robust in the presence of disk magnetic fields and turbulence. The computed oscillation mode frequencies are largely consistent with the observed values for HFQPOs in BH X-ray binaries. The approximate 2:3 frequency ratio is also expected from this model. The connection of HFQPOs with other disk properties (such as production of episodic jets) is also discussed., Comment: 6 pages. Proceedings of IAUS 290 "Feeding Compact Objects: Accretion on All Scales", C. M. Zhang, T. Belloni, M. Mendez & S. N. Zhang (eds.)

The morphological and biochemical changes were studied in adult Sprague-Dawley rats after hemisection at the L3 spinal cord level. After survival periods of one, two and three months, fluorescent tracers, FluoroGold or rhodamine B, were implanted into the dorsal white columns of these rats at the positions of the corticospinal tract below the lesion. Following uptake of the tracer, the rats were killed and the motor cortices and spinal cords of both control and hemisected rats were analysed for positively labelled neurons. The highest number of labelled cells were found two months after hemisection. They were present in both sides of the cortices, particularly in the contralateral cortex, and also in the gray matter of the spinal cord above the hemisection. A few rats which were subjected to complete transection of the spinal cord also showed labelling of neurons in the motor cortex two months after lesion. The Protargol silver technique and the [3H]choline uptake study confirmed the presence of nerve fibres traversing the lesion site in the hemisected spinal cord. Furthermore, when the rats that had been hemisected two months earlier were subjected to a second cut at the same site, chromatolytic neurons were observed in the spinal cord as well as in the motor cortices of both sides. The hemisected rats demonstrated limited recovery in limb movement. The evidence of this study clearly shows that sprouting of nerve fibres has occurred in the lesioned adult rat spinal cord.

The present study showed that prenatal cocaine exposure (60 mg/kg/day) has transient effect on the [3H]mazindol-labelled dopamine uptake sites in the striatum of the rat offspring examined from postnatal week 0–32. There is a 39% and 21% decrease in the number of binding sites (Bmax) in the cocaine-exposed group at postnatal weeks 3 and 4, respectively, with a recovery to near normal values by postnatal week 8.

Waves reflected by the inner edge of a protoplanetary disk are shown to significantly modify Type I migration, even allowing the trapping of planets near the inner disk edge for small planets in a range of disk parameters. This may inform the distribution planets close to their central stars, as observed by the Kepler mission., Comment: 6 pages, 3 figures, accepted by ApJ

The resonant excitation of neutron star (NS) modes by tides is investigated as a source of short gamma-ray burst (sGRB) precursors. We find that the driving of a crust-core interface mode can lead to shattering of the NS crust, liberating ~10^46-10^47 erg of energy seconds before the merger of a NS-NS or NS-black hole binary. Such properties are consistent with Swift/BAT detections of sGRB precursors, and we use the timing of the observed precursors to place weak constraints on the crust equation of state. We describe how a larger sample of precursor detections could be used alongside coincident gravitational wave detections of the inspiral by Advanced LIGO class detectors to probe the NS structure. These two types of observations nicely complement one another, since the former constrains the equation of state and structure near the crust-core boundary, while the latter is more sensitive to the core equation of state., 5 pages, 2 figures. Accepted to PRL

We study the effect of corotation resonance on the inertial-acoustic oscillations (p-modes) of black-hole accretion discs. Previous works have shown that for barotropic flows (where the pressure depends only on the density), wave absorption at the corotation resonance can lead to mode growth when the disc vortensity, $\zeta=\kappa^2/(2\Omega\Sigma)$ (where $\Omega, \kappa, \Sigma$ are the rotation rate, radial epicyclic frequency and surface density of the disc, respectively), has a positive gradient at the corotation radius. Here we generalize the analysis of the corotation resonance effect to non-barotropic fluids. We show that the mode instability criterion is modified by the finite radial Brunt-V\"as\"al\"a frequency of the disc. We derive an analytic expression for the reflectivity when a density wave impinges upon the corotation barrier, and calculate the frequencies and growth rates of global p-modes for disc models with various $\alpha$-viscosity parameterizations. We find that for disc fluids with constant adiabatic index $\Gamma$, super-reflection and mode growth depend on the gradient of the effective vortensity, $\zeta_{\rm eff} = \zeta/S^{2/\Gamma}$ (where $S \equiv P/\Sigma^{\Gamma}$ measures the entropy): when $d\zeta_{\rm eff}/dr > 0$ at the corotation radius, wave absorption leads to amplification of the p-mode. Our calculations show that the lowest-order p-modes with azimuthal wave number $m=2, 3, 4,...$ have the largest growth rates, with the frequencies approximately in (but distinct from) the $2:3:4...$ commensurate ratios. We discuss the implications of our results for the high-frequency quasi-periodic oscillations observed in accreting black-hole systems., Comment: 12 pages, 5 figures, published in MNRAS

We study the global stability of non-axisymmetric p-modes (also called inertial-acoustic modes) trapped in the inner-most regions of accretion discs around black holes. We show that the lowest-order (highest-frequency) p-modes, with frequencies $\omega=(0.5-0.7) m\Omega_{\rm ISCO}$, can be overstable due to general relativistic effects, according to which the radial epicyclic frequency is a non-monotonic function of radius near the black hole. The mode is trapped inside the corotation resonance radius and carries a negative energy. The mode growth arises primarily from wave absorption at the corotation resonance, and the sign of the wave absorption depends on the gradient of the disc vortensity. When the mode frequency is sufficiently high, such that the slope of the vortensity is positive at corotation positive wave energy is absorbed at the resonance, leading to the growth of mode amplitude. We also study how the rapid radial inflow at the inner edge of the disc affects the mode trapping and growth. Our analysis of the behavior of the fluid perturbations in the transonic flow near the ISCO indicates that, while the inflow tends to damp the mode, the damping effect is sufficiently small under some conditions so that net mode growth can still be achieved. We further clarify the role of the Rossby wave instability and show that it does not operate for black hole accretion discs with smooth-varying vortensity profiles. Overstable non-axisymmetric p-modes driven by the corotational instability provide a plausible explanation for the high-frequency (> 100 Hz) quasi-periodic oscillations (HFQPOs) observed from a number of black-hole X-ray binaries in the very high state. The absence of HFQPOs in the soft (thermal) state may result from mode damping due to the radial infall at the ISCO., Comment: 19 pages, 11 figures, MNRAS in press

In differentially rotating discs with no self-gravity, density waves cannot propagate around the corotation, where the wave pattern rotation speed equals the fluid rotation rate. Waves incident upon the corotation barrier may be super-reflected (commonly referred to as corotation amplifier), but the reflection can be strongly affected by wave absorptions at the corotation resonance/singularity. The sign of the absorption is related to the Rossby wave zone very near the corotation radius. We derive the explicit expressions for the complex reflection and transmission coefficients, taking into account wave absorption at the corotation resonance. We show that for generic discs, this absorption plays a much more important role than wave transmission across the corotation barrier. Depending on the sign of the gradient of the specific vorticity of the disc the corotation resonance can either enhance or diminish the super-reflectivity, and this can be understood in terms of the location of the Rossby wave zone relative to the corotation radius. Our results provide the explicit conditions (in terms of disc thickness, rotation profile and specific vorticity gradient) for which super-reflection can be achieved. Global overstable disc modes may be possible for discs with super-reflection at the corotation barrier., 16 pages, 5 figures, MNRAS in press

Thermal noise is expected to be the dominant source of noise in the most sensitive frequency band of second generation ground based gravitational wave detectors. Reshaping the beam to a flatter wider profile which probes more of the mirror surface reduces this noise. The "Mesa" beam shape has been proposed for this purpose and was subsequently generalized to a family of hyperboloidal beams with two parameters: twist angle alpha and beam width D. Varying alpha allows a continuous transition from the nearly-flat to the nearly-concentric Mesa beam configurations. We analytically prove that in the limit of infinite D hyperboloidal beams become Gaussians. The Advanced LIGO diffraction loss design constraint is 1 ppm per bounce. In the past the diffraction loss has often been calculated using the clipping approximation that, in general, underestimates the diffraction loss. We develop a code using pseudo-spectral methods to compute the diffraction loss directly from the propagator. We find that the diffraction loss is not a strictly monotonic function of beam width, but has local minima that occur due to finite mirror effects and leads to natural choices of D. For the Mesa beam a local minimum occurs at D = 10.67 cm and leads to a diffraction loss of 1.4 ppm. We find that if one requires a diffraction loss of strictly 1 ppm, the alpha = 0.91 pi hyperboloidal beam is optimal, leading to the coating thermal noise being lower by about 10% than for a Mesa beam while other types of thermal noise decrease as well. We then develop an iterative process that reconstructs the mirror to specifically account for finite mirror effects. This allows us to increase the D parameter and lower the coating noise by about 30% compared to the original Mesa configuration., Comment: 13 pages, 12 figures, 4 tables. Referee input included and typos fixed. Accepted by Phys. Rev. D

In the present study, we observed that isoproterenol, a beta-adrenergic receptor (beta-AR) agonist, stimulated rat C6 glioma cell proliferation, while propranolol, a beta-AR blocker, greatly reduced the proliferative effect of TNF-alpha on C6 cells. The gene and protein expressions of both beta1- and beta2-ARs were enhanced in C6 cells after TNF-alpha treatment, and the increase in beta-AR was due to an increased number of binding sites and not due to increase in receptor affinity. We further showed that protein kinase C (PKC) was involved in the TNF-alpha-induced beta-AR expression. Collectively, our results indicate that TNF-alpha-induced proliferation in C6 glioma cells might be via the induction and activation of beta-ARs.