Search

Your search keyword '"David Soullez"' showing total 9 results
Start Over Author "David Soullez"
9 results on '"David Soullez"'

1. Syntheses of three new lithio hexavinylogation reagents

Author

Yvan Ramondenc, Gérard Plé, Pierre Villiers, David Soullez, Institut de Chimie Organique Fine (IRCOF), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), Chimie Organique et Bioorganique : Réactivité et Analyse (COBRA), Institut Normand de Chimie Moléculaire Médicinale et Macromoléculaire (INC3M), Institut de Chimie du CNRS (INC)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Université Le Havre Normandie (ULH), Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Institut de Chimie du CNRS (INC)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie Organique Fine (IRCOF), and Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)

Subjects
polyenes, Ether, Conjugated system, 010402 general chemistry, 01 natural sciences, Biochemistry, Aldehyde, polyenals, Benzaldehyde, chemistry.chemical_compound, lithium and compounds, Drug Discovery, [CHIM]Chemical Sciences, Organic chemistry, Reactivity (chemistry), ComputingMilieux_MISCELLANEOUS, hexavinylogation, chemistry.chemical_classification, [CHIM.ORGA]Chemical Sciences/Organic chemistry, 010405 organic chemistry, Organic Chemistry, Condensation, [CHIM.CATA]Chemical Sciences/Catalysis, [CHIM.MATE]Chemical Sciences/Material chemistry, 0104 chemical sciences, chemistry, Reagent
Abstract

Syntheses of new lithio hexavinylogation reagents are described starting either from ω-bromo polyenacetal, ω-bromo polyenol ether or ω-bromo non conjugated aldehyde. The reactivity of the lithio reagents has been tested by condensation with benzaldehyde; the resulting hexaenal has been obtained in a one or two steps procedure.

Published
1999
Full Text
View/download PDF

2. New spermine and spermidine derivatives as potent inhibitors of Trypanosoma cruzi Trypanothione Reductase

Author

Christian Sergheraert, David Soullez, Valérie Landry, Elisabeth Davioud-Charvet, Beatrice Bonnet, and Dragos Horvath

Subjects
Spermidine, Trypanosoma cruzi, Clinical Biochemistry, Protozoan Proteins, Pharmaceutical Science, Spermine, Biochemistry, Compound 32, Structure-Activity Relationship, chemistry.chemical_compound, parasitic diseases, Drug Discovery, Animals, NADH, NADPH Oxidoreductases, Enzyme Inhibitors, Molecular Biology, biology, Organic Chemistry, biology.organism_classification, chemistry, Molecular Medicine, Trypanothione reductase
Abstract

Several spermine and spermidine derivatives containing 2-amino diphenylsulfide substituents were prepared and tested for their inhibiting effects on Trypanosoma cruzi trypanothione reductase. IC 50 values were assessed between 0.3 and 3 μM. Compound 32 ( K i = 0.4 μM) is the most potent TR inhibitor described so far.

Published
1997
Full Text
View/download PDF

3. ω-Halogeno polyenals: preparation and application to a one-pot synthesis of polyenals from carbonyl compounds

Author

Lucette Duhamel, David Soullez, and Gérard Plé

Subjects
chemistry.chemical_classification, biology, Potassium, One-pot synthesis, Condensation, Salt (chemistry), chemistry.chemical_element, Conjugated system, biology.organism_classification, chemistry.chemical_compound, chemistry, Furan, Glutaconaldehyde, Tetra, Organic chemistry
Abstract

Syntheses of 5-halogeno-2,4-dienals 1a–c are described starting either from the glutaconaldehyde potassium salt or from furan. The 5-bromopenta-2,4-dienal 1b can be transformed efficiently into homologous ω-bromo polyenals 2–4, precursors of ω-bromo polyenol ethers 5b,d, 6 and 7. After bromine–lithium exchange, followed by condensation with carbonyl compounds, 1-bromo-6-methoxyhexa-1,3,5-triene 5b, 1-bromo-8-methoxyocta-1,3,5,7-tetraene 6 and 1-bromo-10-methoxydeca-1,3,5,7,9-pentene 7 lead to various conjugated tri-, tetra- and penta-enals in good yields, in a one-pot procedure.

Published
1997
Full Text
View/download PDF

5. ChemInform Abstract: ω-Halogeno Polyenals: Preparation and Application to a One-Pot Synthesis of Polyenals from Carbonyl Compounds

Author

David Soullez, Lucette Duhamel, and Gérard Plé

Subjects
chemistry.chemical_classification, biology, Potassium, Condensation, One-pot synthesis, chemistry.chemical_element, Salt (chemistry), General Medicine, Conjugated system, biology.organism_classification, chemistry.chemical_compound, chemistry, Furan, Glutaconaldehyde, Organic chemistry, Tetra
Abstract

Syntheses of 5-halogeno-2,4-dienals 1a–c are described starting either from the glutaconaldehyde potassium salt or from furan. The 5-bromopenta-2,4-dienal 1b can be transformed efficiently into homologous ω-bromo polyenals 2–4, precursors of ω-bromo polyenol ethers 5b,d, 6 and 7. After bromine–lithium exchange, followed by condensation with carbonyl compounds, 1-bromo-6-methoxyhexa-1,3,5-triene 5b, 1-bromo-8-methoxyocta-1,3,5,7-tetraene 6 and 1-bromo-10-methoxydeca-1,3,5,7,9-pentene 7 lead to various conjugated tri-, tetra- and penta-enals in good yields, in a one-pot procedure.

Published
2010
Full Text
View/download PDF

6. ChemInform Abstract: Syntheses of Three New Lithio Hexavinylogation Reagents

Author

Gérard Plé, Yvan Ramondenc, Pierre Villiers, and David Soullez

Subjects
chemistry.chemical_classification, Benzaldehyde, chemistry.chemical_compound, chemistry, Reagent, Condensation, Organic chemistry, Ether, Reactivity (chemistry), General Medicine, Conjugated system, Aldehyde
Abstract

Syntheses of new lithio hexavinylogation reagents are described starting either from ω-bromo polyenacetal, ω-bromo polyenol ether or ω-bromo non conjugated aldehyde. The reactivity of the lithio reagents has been tested by condensation with benzaldehyde; the resulting hexaenal has been obtained in a one or two steps procedure.

Published
2010
Full Text
View/download PDF

7. Trypanothione reductase inhibition/trypanocidal activity relationships in a 1,4-bis(3-aminopropyl)piperazine series

Author

Sophie Girault, David Soullez, Valérie Landry, Louis Maes, Christian Sergheraert, Beatrice Bonnet, and Elisabeth Davioud-Charvet

Subjects
Magnetic Resonance Spectroscopy, Stereochemistry, Cell Survival, Trypanosoma cruzi, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Chemical synthesis, Piperazines, Cell Line, chemistry.chemical_compound, Structure-Activity Relationship, parasitic diseases, Drug Discovery, Potency, Animals, Humans, NADH, NADPH Oxidoreductases, Molecular Biology, chemistry.chemical_classification, biology, Chemistry, Organic Chemistry, biology.organism_classification, Trypanocidal Agents, In vitro, Enzyme, Enzyme inhibitor, biology.protein, Molecular Medicine, Trypanothione reductase, Polyamine
Abstract

A series of symmetrically substituted 1,4-bis(3-aminopropyl)piperazines was synthesized and tested towards trypanothione reductase and for its in vitro trypanocidal potency. The most trypanocidal amongst them was found to be totally inactive towards the enzyme and thus constitutes a lead structure for the identification of new potential Trypanosoma cruzi target(s).

Published
2000

8. Handy Access to Navenones A, B and C

Author

Gérard Plé, Yvan Ramondenc, David Soullez, Lucette Duhamel, Institut de Chimie Organique Fine (IRCOF), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), Chimie Organique et Bioorganique : Réactivité et Analyse (COBRA), Institut Normand de Chimie Moléculaire Médicinale et Macromoléculaire (INC3M), Institut de Chimie du CNRS (INC)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Université Le Havre Normandie (ULH), Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Institut de Chimie du CNRS (INC)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie Organique Fine (IRCOF), and Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)

Subjects
010405 organic chemistry, Chemistry, [CHIM.ORGA]Chemical Sciences/Organic chemistry, Ω-lithio polyenol ether, polyvinylogation, Navenones, [CHIM.CATA]Chemical Sciences/Catalysis, [CHIM.MATE]Chemical Sciences/Material chemistry, 010402 general chemistry, 01 natural sciences, 3. Good health, 0104 chemical sciences, Alarm pheromones, One pot reaction, Reagent, Molecular Medicine, Organic chemistry, [CHIM]Chemical Sciences, ComputingMilieux_MISCELLANEOUS
Abstract

Alarm pheromones, Navenones A, B and C 1a-c are synthesized in a one pot reaction by the means of a powerful polyvinylogation reagent the 6-lithio-1-methoxyhexa-1,3,5-triene 3.

Published
1994
Full Text
View/download PDF

9. 5-Bromopentadienal: a versatile intermediate for the synthesis of functionalized polyenic compounds

Author

Pierre Duhamel, David Soullez, Gérard Plé, and Lucette Duhamel

Subjects
chemistry.chemical_classification, chemistry.chemical_compound, Diene, Chemistry, Potassium, Glutaconaldehyde, Diol, Molecular Medicine, Salt (chemistry), Organic chemistry, chemistry.chemical_element
Abstract

5-Bromopentadienal 1b(n= 2), easily obtained from the potassium glutaconaldehyde salt, is used as precursor of ω-bromoheptatrienal 1d, ω-bromomethoxyhexatriene 2, diene diols 4, diene diones 5, 1,6-dibromohexa-1,3,5-triene 6 and 1,8 triene diol 8, of controlled configuration.

Published
1995
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results