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In the 1966 article “Word, Dialogue, and Novel,” Julia Kristeva introduces the concept of intertextuality through her study of Mikhail Bakhtin’s tracing of multivalent voices in Dostoevsky’s polyph...

Brian Bruce’s 2006 biography is appropriately titled, Thomas Boyd: Lost Author of the “Lost Generation.” Not many readers are familiar with Thomas Boyd, even though his Through the Wheat is general...

In “Going to Meet the Man,” James Baldwin illustrates Flannery O’Connor’s theory that violence serves as a catalyst for a “moment of grace.” Through the remembrances of the main character during on...

Sarah Ruden provides the best translation of Aristophanes’s Lysistrata. She effectively addresses feminism (as demonstrated by theories of Sheila Jeffreys and Naomi Wolf) through transgressive writing for a contemporary audience. Ruden allows her characters to establish a speech community through their language. The argument that Ruden’s translation is superior is supported by a comparison of several passages of Ruden’s Lysistrata to other translations, an examination of selected criticism of Ruden’s Lysistrata, and a look at Ruden’s own commentary about her play.

BACKGROUND Resection (R) followed by single- or multi-fraction stereotactic radiosurgery (SRT) of brain metastases (BMs) lowers resection bed recurrence compared to R alone. Nevertheless, for larger BMs, 12-month recurrence rates after R+SRT can exceed 20–30%. Aiming to improve outcomes, a permanently implanted collagen tile brachytherapy device (GammaTile, GT Medical Technologies, Tempe, AZ) utilizing Cs-131 seeds embedded within a bioresorbable collagen tile was developed and is described as Surgically Targeted Radiation Therapy (STaRT) to distinguish it from external beam radiotherapy. STaRT allows rapid, intense localized radiation dose delivery directly to the tumor bed with predictable dosimetry immediately at the time of R, which may confer reduced risk for radiation necrosis compared to other therapies. It is hypothesized that R+ STaRT will increase surgical bed recurrence-free survival (SB-RFS), while reducing impact on functional and neurocognitive status compared to R+SRT. METHODS Multicenter, randomized, comparison trial of patients with resectable, previously untreated “index” BMs (≥ 2.5–5cm), and 0–3 other tumors, will be preoperatively randomized 1:1 to undergo R+SRT or R+STaRT to the index lesion; unresected tumors in both groups will receive SRT. Planned sample size is 180 from 14 sites. Enrollment opened 03/31/2021. First subject was enrolled 04/07/2021. Primary endpoint is SB-RFS. Secondary endpoints include overall survival, quality of life, neurocognition, functional status, imaging findings and adverse events. Follow-up will be through 24 months. This will be the first randomized trial comparing R+SRT versus R+STaRT delivered by Cs-131 sources in permanently implanted resorbable collagen tile carriers. Primary and secondary outcome measures captured will elucidate the potential risks and benefits of these two RT delivery methods in the setting of newly diagnosed BMs. We will present trial accrual progress, available data, experience and lessons learned.

BACKGROUND For patients with operable intracranial neoplasms, there are opportunities to augment local control beyond traditional methods, such as external beam radiation therapy. Brachytherapy, the implantation of radioactive sources into the resection cavity, can be useful in this setting by providing immediate initiation of radiation and limiting the exposure of surrounding normal tissue to radiation. Traditional intracranial brachytherapy has been limited by uneven dose distributions, complicated workflows, extended procedural times, cost of dedicated equipment, and frequent adverse events. To address these issues, a permanently implanted device with Cs-131 radiation seeds embedded in a bioresorbable collagen carrier tile (GammaTile, GT Medical Technologies, Tempe, AZ USA) was developed. Described as surgically targeted radiation therapy (STaRT), it is FDA-cleared for use in newly-diagnosed malignant intracranial neoplasms and recurrent intracranial tumors, and has demonstrated excellent safety and efficacy in early commercial use. The primary objectives of this multicenter, prospective, observational (phase IV) registry study are to evaluate “real-world” clinical outcomes and patient-reported outcomes that measure the safety and efficacy of STaRT using the GammaTile. METHODS Patients undergoing resection (R) of brain tumors with intra-operative GammaTile placement are eligible for enrollment. Planned sample size is 600 at up to 50 enrolling sites. First subject was enrolled 10/14/2020. Tumor pathology, overall survival, radiation- and surgery-related adverse events, patient- and provider-reported quality of life, serial MRIs, and timing of surgical bed and/or distant recurrence are collected. Powered primary endpoints for recurrent brain metastases, recurrent glioblastoma, and recurrent meningioma (surgical bed-progression free survival (PFS), overall survival, and PFS, respectively), compare STaRT to standard-of-care benchmarks. Results will be used to improve awareness and access to this treatment, benchmark clinical outcomes in the real-world setting, allow for comparisons to existing treatments, facilitate the design of future clinical trials, and contribute to the optimal sequencing of treatments for intracranial neoplasms.

Over two centuries separate Susanna Rowson’s Charlotte Temple and Tom Wolfe’s I Am Charlotte Simmons, but both novels chronicle in similar ways how two young women named Charlotte succumb to the fa...

F. Scott Fitzgerald never addressed the causes underlying his alcoholism through Buchmanism, the Oxford Group, or Alcoholics Anonymous. Fitzgerald believed he could stop drinking through self-will,...

The BizCafe Interpretive Simulation is a good resource for teaching a restaurant business start-up. The simulation replicates the real life business of running a coffee shop. Each student will assume the role of coffee shop manager, and will make all the decisions necessary to survive in a competitive environment. The decisions encompass several aspects of the restaurant business. In the start-up period, determining the hours of operation, coffee prices, and wages are among the decisions. As in real life, some of the decisions—like whether or not to buy a pastry oven—are irreversible, with ramifications that will impact revenues and costs throughout the duration of the simulation. However, coffee prices and wages can be changed, based on analysis of the competitive set. As in any business venture, this is a contest to see who can survive. In this competitive set, there will be winners and losers, based on who has made the best decisions.

Hannah Webster Foster's The Coquette; Or, The History of Eliza Wharton; A Novel; Founded on Fact addresses issues related to feminism, gender, genre, politics, and ethics. Interpreting Foster's 179...

In the tradition of the bildungsroman, the two volumes of John Cleland’s Fanny Hill, or Memoirs of a Woman of Pleasure (1748–49) conveniently divide the main character’s sexual initiation into peri...

Objective To describe nontraditional roles for Certified Pharmacy Technicians (CPhTs) within pharmaceutical industry. Setting Drug information department within a large biotechnology/pharmaceutical organization. Practice Description The Medical Communications department within Genentech uses a skills-mix staffing model in which employees with varying educational and training backgrounds work as a team on meeting the informational needs of consumers and health professionals who contact the company. One position within the department is that of Medical Communications Associate, responsible primarily for managing product inquiries. Practice Innovation Medical Communications Associates have degrees in life sciences or an equivalent combination of education and experience, including a minimum of 2 years of related experience in the health care industry. Currently, four of the seven Medical Communications Associates in the department are CPhTs. Interventions Not applicable. Main Outcome Measure Ability to recruit CPhTs for Medical Communications Associate positions, and job satisfaction of those hired into these positions. Results Critical basic skills needed for the Medical Communications Associate position include strong computer literacy, ability to multitask, and ability to work in an environment with frequent interruptions. Strong oral and written communications skills, customer service skills, ability to deal with stressful situations, product–specific knowledge, ability to work on a daily basis with Medical Communications Pharmacists, and knowledge of medical terminology are also important. The skills set of CPhTs matches these requirements, as evidenced by the experiences of the four staff members who have worked in the department for a total of 17 person–years. Conclusion This nontraditional role for CPhTs can be rewarding and beneficial to all, affording an unique opportunity within the pharmaceutical industry. The skill set and experience of CPhTs can be used in the nontraditional pharmacy practice setting of drug information.

Global education has been defined as a process that provides students and individuals with the knowledge, skills, and attitudes necessary for them to meet their responsibilities as citizens of their community, state, and nation in an increasingly interdependent and complex global society (Florida Task Force, 1982). The development of agricultural industry in any country is inextricably linked to changes in global economy and educational advancement. The mission of agricultural education in the United States is to foster the development of knowledge and skills related to the industry of agriculture (National Task Force, 1987). To compete effectively in the ever changing, complex international labor force, agriculturally educated individuals must understand the global nature of agricultural industry and its effects on United States domestic food production, distribution, and consumption. In 1988, the National Research Council recommended that the dominance of local production agriculture in the curriculum must be broadened to include global concepts on utilization of agricultural commodities, distribution, and management. The implementation of this recommendation requires a major change in the agricultural curriculum. This curriculum change will require teachers who are committed to internationalizing their agricultural programs.

An assessment center is a place and process where individuals are evaluated for managerial capabilities in order to select, promote, or facilitate the development of an individualized training program in an organization (Thornton & Byham, 1982). Assessment center personnel conduct a job analysis to describe the attitudes, knowledge, and skills required for management positions. The attitudes, knowledge, and skills derived from the job analysis are then used to design assessment center activities. Assessment center participants are involved in selected activities while their managerial capabilities are being determined by trained evaluators. Assessment centers attempt to measure managerial capabilities for the purpose of assessment, selection, promotion, and training (Thornton & Byham, 1982).

In Raymond Carver’s “Careful”, “Gazebo”, and “Chef’s House”, characters depend on the process of drinking as a paradigm to understand their lives. In these three stories, the characters rely upon alcohol as a solution to problems paradoxically caused by their addiction to alcohol.