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1. Lung cancer trends and tumor characteristic changes over 20 years (2000–2020): Results of three French consecutive nationwide prospective cohorts’ studies

Author

Didier Debieuvre, Olivier Molinier, Lionel Falchero, Chrystèle Locher, Dorine Templement-Grangerat, Nicolas Meyer, Hugues Morel, Yannick Duval, Bernard Asselain, Alexia Letierce, Jean Trédaniel, Jean-Bernard Auliac, Olivier Bylicki, Lionel Moreau, Mathieu Fore, Romain Corre, Sébastien Couraud, Alexis Cortot, Faraj Al Freijat, Waad Al Sheikh, Claire Alizon, Karim Amrane, Etienne Auvray, Nicolae Banciu, Alexandra Bedossa, Issam Belhaj, Antoine Belle, Laure Belmont, Kheir Eddine Benmammar, Marie Bernardi, Pascal Beynel, Fréderic Bigot, Acya Bizieux-Thaminy, Anne-Sophie Blanchet-Legens, Philippe Bonnefoy, Soraya Bordier, Anne-Sophie Bravard, Éric Briens, Philippe Brun, Anne-Sophie Bugnet, Laetitia Chablais, Anne-Marie Chiappa, Reda Chikouche, François Christiann, Caroline Clarot, Joelle Courdeau-Labourie, Jacky Crequit, Charles Dayen, Gonzague De chabot, Chantal Decroisette, Stéphanie Dehette, Christian Delafosse, Bertrand Delclaux, Christina Delmas, Pierre Demontrond, Jean-Marc Dot, Cécile Dujon, Patrick Dumont, Christine Dussopt, Fatima Duval, Fethi El Khanjari, Kevin Fouet, Hugues Francois, Yannick Ghalloussi-Tebai, Éric Goarant, Benoît Godbert, François Goupil, Rym Haouachi, Pierre-Alexandre Hauss, Mohamad Jaafar, Baihas Jarjour, Serge Jeandeau, Sylvie Julien, Jean Philippe Kraemer, Pierre Kuntz, Florence Lamotte, Sébastien Larive, Thomas Laurent, Hervé Le Floch, Gwenaëlle Le Garff, Jacques Le Treut, Emmanuelle Lecuyer, Christine Lefoll, Olivier Leleu, Marguerite Lepoulain Doubliez, Virginie Levrat, Sandrine Loutski-Vettese, Edith Maetz, Fanny Magne, Cécile Maincent, Alexa Mairovitz, Catherine Marichy, Nancy Marion, David Marquette, Bénédicte Martignac, Stéphanie Martinez, Clothilde Marty, Philippe Masson, Cyril Maurer, Vincent Meniai, Geoffroy Milliet De Faverges, Isabelle Monnet, Laurent Mosser, Anne-Catherine Neidhardt, David Nunes, Julie Obert, Vanessa Pante, Magalie Paysse, Herve Pegliasco, Jean-Michel Peloni, Christophe Perrin, Lidia Petit, Marjorie Picaud, Julian Pinsolle, Mihai Popa, Laurent Portel, Jean Quieffin, Hong Rabut, Élise Redureau, David Renault, Patrick Aldo Renault, Claudia Rizzo, Maud Russier, Marielle Sabatini, Thierry Saelens, Sophie Schneider, Philippe Slaouti, Luc Stoven, Vincent Tack, Jean-Yves Tavernier, Laurence Thirard, Séverine Thomassin, Marie Tiercin, Jean Tredaniel, Andreea Tudor, Amélie Turlotte, Colette Vincent, and Jérôme Virally

Subjects
Lung cancer, Smoking habits, Real-life, Tumor characteristics, Adenocarcinoma, Non-small-cell lung cancer, Public aspects of medicine, RA1-1270
Abstract

Summary: Background: Long-term changes in lung cancer (LC) patients are difficult to evaluate. We report results from the French KBP-2020 real-life cohort. Methods: KBP-2020 was a prospective cohort that included all patients diagnosed with LC in 2020, in nonacademic public hospital in France. Patient and tumour characteristics were described and compared with similarly designed cohorts in 2000 and 2010. Findings: In 2020, 82 centers included 8,999 patients diagnosed with LC. The proportion of women increased: 34·6% (3114/8999) compared to, 24·3% (1711/7051) and 16·0% (904/5667) in 2010 and 2000 (p

Published
2022
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2. Women and COPD: do we need more evidence?

Author

Christophe Gut-Gobert, Arnaud Cavaillès, Adrien Dixmier, Stéphanie Guillot, Stéphane Jouneau, Christophe Leroyer, Sylvain Marchand-Adam, David Marquette, Jean-Claude Meurice, Nicolas Desvigne, Hugues Morel, Christine Person-Tacnet, and Chantal Raherison

Subjects
Diseases of the respiratory system, RC705-779
Abstract

The increasingly female face of chronic obstructive pulmonary disease (COPD) prevalence among women has equalled that of men since 2008, due in part to increased tobacco use among women worldwide and exposure to biomass fuels. This finding is supported by a number of characteristics. There is evidence of susceptibility to smoking and other airborne contaminants, along with epidemiological and phenotypic manifestations. COPD has thus become the leading cause of death in women in the USA. The clinical presentation is characterised by increasingly pronounced dyspnoea with a marked tendency towards anxiety and depression, undernutrition, nonsmall cell lung cancer (especially adenocarcinoma) and osteoporosis. Quality of life is also more significantly impacted. The theories advanced to explain these differences involve the role played by oestrogens, impaired gas exchange in the lungs and smoking habits. While these differences require appropriate therapeutic responses (smoking cessation, pulmonary rehabilitation, long-term oxygen therapy), barriers to the treatment of women with COPD include greater under-diagnosis than in men, fewer spirometry tests and medical consultations. Faced with this serious public health problem, we need to update and adapt our knowledge to the epidemiological changes.

Published
2019
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3. Risk factors for early mortality from lung cancer: evolution over the last 20 years in the French nationwide KBP cohorts

Author

Debieuvre, D., Asselain, B., Cortot, A., Couraud, S., Duval, Y., Falchero, L., Locher, C., Meyer, N., Molinier, O., Morel, H., Templement-Grangerat, D., Tredaniel, J., Olivier, Leleu, Caroline, Clarot, Stéphanie, Martinez, Marie, Bernardi, Etienne, Auvray, Julian, Pinsolle, Chantal, Decroisette, Dorine, Templement, Laure, Belmont, Thierry, Saelens, Amélie, Turlotte, Jérôme, Virally, Reda, Chikouche, Marielle, Sabatini, Sophie, Schneider, Jacky, Crequit, Faraj, Al Freijat, Baihas, Jarjour, Rym, Haouachi, Fethi, El Khanjari, Luc, Stoven, Pascal, Beynel, Vincent, Tack, Fatima, Meniai, Yannick, Duval, Hannah, Ghalloussi-Tebai, Claudia, Rizzo, Waad, Al Sheikh, Marguerite, Lepoulain Doubliez, Florence, Lamotte, François, Christiann, Patrick, Dumont, Philippe, Masson, Fréderic, Bigot, Hervé, Le Floch, Issam, Belhaj, Lionel, Moreau, Stéphanie, Dehette, Antoine, Belle, Lidia, Petit, Thomas, Laurent, Sandrine, Loutski-Vettese, Isabelle, Monnet, Jean-Bernard, Auliac, Edith, Maetz, Jean-Yves, Tavernier, Christian, Delafosse, Pierre-Alexandre, Hauss, Colette, Vincent, Mohamad, Jaafar, Jean Philippe, Kraemer, Laetitia, Chablais, Anne-Sophie, Bravard, Philippe, Bonnefoy, Christine, Lefoll, Alexandra, Bedossa, Élise, Redureau, Acya, Bizieux-Thaminy, Virginie, Levrat, Kevin, Fouet, Claire, Alizon, Cécile, Dujon, Hong, Rabut, Mihai, Popa, Jean, Quieffin, Pierre, Demontrond, Olivier, Molinier, François, Goupil, Kheir Eddine, Benmammar, Vanessa, Pante, Laurent, Portel, Anne-Sophie, Blanchet-Legens, Sébastien, Larive, Jacques, Le Treut, Herve, Pegliasco, Chrystèle, Locher, Séverine, Thomassin, Benoît, Godbert, Cécile, Maincent, Christophe, Perrin, Julie, Obert, Cyril, Maurer, David, Renault, Karim, Amrane, Didier, Debieuvre, Geoffroy, Milliet De Faverges, Andreea, Tudor, Maud, Russier, Hugues, Morel, Hugues, Francois, Jean, Tredaniel, Patrick Aldo, Renault, Magalie, Paysse, Anne-Marie, Chiappa, Romain, Corre, Laurent, Mosser, Sylvie, Julien, David, Nunes, Soraya, Bordier, Eric, Briens, Gwenaëlle, Le Garff, Clothilde, Marty, Bénédicte, Martignac, Charles, Dayen, Emmanuelle, Lecuyer, Philippe, Slaouti, Serge, Jeandeau, Christina, Delmas, Eric, Goarant, Marie, Tiercin, Jean-Michel, Peloni, Joelle, Courdeau-Labourie, Nicolae, Banciu, Anne-Sophie, Bugnet, Olivier, Bylicki, Marjorie, Picaud, Laurence, Thirard, Bertrand, Delclaux, Philippe, Brun, Marion, Nancy, David, Marquette, Gonzague, De Chabot, Pierre, Kuntz, Catherine, Marichy, Lionel, Falchero, Christine, Dussopt, Alexa, Mairovitz, Jean-Marc, Dot, Fanny, Magne, Hoang, T.C.T., Bravard, A.-S., Martinez, S., Le Garff, G., Jeandeau, S., Petit, L., Marquette, D., Amrane, K., Demontrond, P., Tiercin, M., Jarjour, B., Turlotte, A., Masson, P., Jaafar, M., and Hauss, P.-A.

Published
2024
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4. Risk factors for early mortality from lung cancer: evolution over the last 20 years in the French nationwide KBP cohorts

Author

Hoang, T.C.T., primary, Debieuvre, D., additional, Bravard, A.-S., additional, Martinez, S., additional, Le Garff, G., additional, Jeandeau, S., additional, Petit, L., additional, Marquette, D., additional, Amrane, K., additional, Demontrond, P., additional, Tiercin, M., additional, Jarjour, B., additional, Turlotte, A., additional, Masson, P., additional, Jaafar, M., additional, Hauss, P.-A., additional, Morel, H., additional, Asselain, B., additional, Cortot, A., additional, Couraud, S., additional, Duval, Y., additional, Falchero, L., additional, Locher, C., additional, Meyer, N., additional, Molinier, O., additional, Templement-Grangerat, D., additional, Tredaniel, J., additional, Olivier, Leleu, additional, Caroline, Clarot, additional, Stéphanie, Martinez, additional, Marie, Bernardi, additional, Etienne, Auvray, additional, Julian, Pinsolle, additional, Chantal, Decroisette, additional, Dorine, Templement, additional, Laure, Belmont, additional, Thierry, Saelens, additional, Amélie, Turlotte, additional, Jérôme, Virally, additional, Reda, Chikouche, additional, Marielle, Sabatini, additional, Sophie, Schneider, additional, Jacky, Crequit, additional, Faraj, Al Freijat, additional, Baihas, Jarjour, additional, Rym, Haouachi, additional, Fethi, El Khanjari, additional, Luc, Stoven, additional, Pascal, Beynel, additional, Vincent, Tack, additional, Fatima, Meniai, additional, Yannick, Duval, additional, Hannah, Ghalloussi-Tebai, additional, Claudia, Rizzo, additional, Waad, Al Sheikh, additional, Marguerite, Lepoulain Doubliez, additional, Florence, Lamotte, additional, François, Christiann, additional, Patrick, Dumont, additional, Philippe, Masson, additional, Fréderic, Bigot, additional, Hervé, Le Floch, additional, Issam, Belhaj, additional, Lionel, Moreau, additional, Stéphanie, Dehette, additional, Antoine, Belle, additional, Lidia, Petit, additional, Thomas, Laurent, additional, Sandrine, Loutski-Vettese, additional, Isabelle, Monnet, additional, Jean-Bernard, Auliac, additional, Edith, Maetz, additional, Jean-Yves, Tavernier, additional, Christian, Delafosse, additional, Pierre-Alexandre, Hauss, additional, Colette, Vincent, additional, Mohamad, Jaafar, additional, Jean Philippe, Kraemer, additional, Laetitia, Chablais, additional, Anne-Sophie, Bravard, additional, Philippe, Bonnefoy, additional, Christine, Lefoll, additional, Alexandra, Bedossa, additional, Élise, Redureau, additional, Acya, Bizieux-Thaminy, additional, Virginie, Levrat, additional, Kevin, Fouet, additional, Claire, Alizon, additional, Cécile, Dujon, additional, Hong, Rabut, additional, Mihai, Popa, additional, Jean, Quieffin, additional, Pierre, Demontrond, additional, Olivier, Molinier, additional, François, Goupil, additional, Kheir Eddine, Benmammar, additional, Vanessa, Pante, additional, Laurent, Portel, additional, Anne-Sophie, Blanchet-Legens, additional, Sébastien, Larive, additional, Jacques, Le Treut, additional, Herve, Pegliasco, additional, Chrystèle, Locher, additional, Séverine, Thomassin, additional, Benoît, Godbert, additional, Cécile, Maincent, additional, Christophe, Perrin, additional, Julie, Obert, additional, Cyril, Maurer, additional, David, Renault, additional, Karim, Amrane, additional, Didier, Debieuvre, additional, Geoffroy, Milliet De Faverges, additional, Andreea, Tudor, additional, Maud, Russier, additional, Hugues, Morel, additional, Hugues, Francois, additional, Jean, Tredaniel, additional, Patrick Aldo, Renault, additional, Magalie, Paysse, additional, Anne-Marie, Chiappa, additional, Romain, Corre, additional, Laurent, Mosser, additional, Sylvie, Julien, additional, David, Nunes, additional, Soraya, Bordier, additional, Eric, Briens, additional, Gwenaëlle, Le Garff, additional, Clothilde, Marty, additional, Bénédicte, Martignac, additional, Charles, Dayen, additional, Emmanuelle, Lecuyer, additional, Philippe, Slaouti, additional, Serge, Jeandeau, additional, Christina, Delmas, additional, Eric, Goarant, additional, Marie, Tiercin, additional, Jean-Michel, Peloni, additional, Joelle, Courdeau-Labourie, additional, Nicolae, Banciu, additional, Anne-Sophie, Bugnet, additional, Olivier, Bylicki, additional, Marjorie, Picaud, additional, Laurence, Thirard, additional, Bertrand, Delclaux, additional, Philippe, Brun, additional, Marion, Nancy, additional, David, Marquette, additional, Gonzague, De Chabot, additional, Pierre, Kuntz, additional, Catherine, Marichy, additional, Lionel, Falchero, additional, Christine, Dussopt, additional, Alexa, Mairovitz, additional, Jean-Marc, Dot, additional, and Fanny, Magne, additional

Published
2024
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5. Prevalence and risk factors of asthma in dairy farmers: Ancillary analysis of AIRBAg

Author

Stéphane Jouneau, Anthony Chapron, Cécile Ropars, Solenne Marette, Ange-Marie Robert, Thomas Gouyet, Chantal Belleguic, Cécile Rochefort-Morel, Stéphanie Guillot, Carole Mailloux, Benoît Desrues, Jean-François Viel, Jean Barakat, Anne-Laure Barel, Henri-Pierre Baron, Rachel Bassen, Florence Behaghel-Baruteau, Cyril Bernier, Séverine Beyer, Romain Boissel, Vanessa Brault, Graziella Brinchault, Dominique Bureau, Odile Castel, Anne-France Cazuguel, Catherine Decelle-Trochet, Marcel Delaunay, Isabelle Delaunay-Lelièvre, Bruno Eveno, Krisztina Fekete, Lisa Fourmont, Amandine Guervin, Tiphaine Guy, Guillaume Héry, Pauline Hardouin, Anne Hespel, Nathalie Jeffray, Yves Koskas, Virginie de Lauzun, Antoine Lebossé, Sandrine Lecot, David Marquette, Virginie Martin, Ahmed Merzoug, Hugues Morel, Jean Morer, Patrick Morisseau, Aurélie Oksenhendler, Elisabeth Orhant, Dominique Peron, Mauricette Piguel-Royer, Marie Pinault, Jean-Paul Pousset, Jean-Claude Presle, Patrick Raillard, Bernard Regnault, Antoine Séguineau, Anne Sevin, Fanny Thépault, Christian Verger, Jonchère, Laurent, Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), CHU Pontchaillou [Rennes], Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Mutualité sociale agricole des Portes de Bretagne, CRLCC Eugène Marquis (CRLCC), Oncogenesis, Stress, Signaling (OSS), Université de Rennes (UR)-CRLCC Eugène Marquis (CRLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM), and This AIRBAg study was supported financially by Rennes University Hospital, France (COREC 2011 funding), the Association for the respiratory insufficiency of Brittany (‘Association pour les insuffisants respiratoires de Bretagne’ (AIRB)), the French Ministry of Labour (DIRECCTE), and Novartis Pharma, France.

Subjects
[SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health, Farmers, Allergy, Wheezing, [SDV]Life Sciences [q-bio], Bronchial obstruction, Biochemistry, Asthma, Chronic respiratory disease, Agricultural Workers' Diseases, [SDV] Life Sciences [q-bio], Cross-Sectional Studies, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Risk Factors, Hypersensitivity, Prevalence, [SDV.EE.SANT] Life Sciences [q-bio]/Ecology, environment/Health, Humans, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, General Environmental Science
Abstract

International audience; BACKGROUND: Prolonged occupational agricultural exposure is associated with an increase in asthma diagnosis. This study aimed to identify the prevalence and risk factors for asthma in dairy farmers. METHODS: AIRBAg was a cross-sectional study including 1203 representative dairy farmers. They completed a self-administered questionnaire and underwent a health respiratory check-up. Referral to a pulmonologist was made for any participant with wheezing, dyspnoea, chronic bronchitis, a chronic cough or a FEV(1)/FEV(6) ratio

Published
2021
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6. Early mortality in real-life nationwide epidemiological study on lung cancer in non-academic French public hospitals

Author

Didier Debieuvre, David Marquette, Jacky Crequit, Jacques Le Treut, Laurent Portel, Reda Chikouche, Hugues François, Charles Dayen, Claudia Rizzo, Eric Goarant, Amélie Turlotte, Baihas Jarjour, Philippe Masson, Mohamad Jaafar, Clothilde Marty, Luc Stoven, Laure Belmont, Christine Le Foll, and David Renault

Subjects
Cancer Research, Oncology
Abstract

10557 Background: Each decade since 2000, the French College of General Hospital Pulmonologists (CPHG) conducts a real-life nationwide prospective epidemiological, observational, multicenter study on lung cancer (LC). In 2020, the CPHG constituted the third cohort, KBP-2020-CPHG. We reported here the data on one-month and three-month mortality among general population of this cohort and compared them with 2010 cohort. Methods: Collection of all consecutive LC histologically or cytologically confirmed between 01/01 and 12/31/2020 in non-academic public hospital pulmonology or oncology units in France. A Scientific Committee controlled inclusion exhaustivity and quality in each center. Results: 82 centers collected 8,999 patients in 2020. One-month mortality was 8.8% (734/8,999) and 9.7% (680/7,051) in 2010. Three-month mortality was 21.5% (1,771/8,999) in 2020 and 23.3% (1,624/7,051) in 2010 (Table 1). According to sex, mortality at one and three months mainly affected men (525/734; 71.5% and 1,259/1,771; 71.1% respectively). Mean age at diagnosis was older than in the cohort population (67.8 y-o); respectively 69.9 and 69.8 at one and three months. At diagnosis, patients were in poorer ECOG mainly grade 2 (211/697; 30.3%) or 3 (194/697; 27.8%) for one-month and mainly grade 1 (549/1,703; 32.2%) or 2 (547/1,703; 32.1%) for three-month mortality. Among ECOG grade 3 and 4, 34.8% (194/557) and 57.1% (93/163) were dead at one month respectively; 63.5% (350/551) and 83.4% (136/163) respectively were dead at three months. According to histology, adenocarcinoma was the most common (308/734; 42%), followed by small cell lung cancer (170/734; 23.2%) at one-month; adenocarcinoma was also the most common (822/1,771; 46.4%), followed by squamous cell carcinoma (380/1771; 21.5%) at three-month mortality. Most patients who died early were stage 4, metastatic/disseminated (respectively 625/702; 89% and 1,488/1,715; 86.8% for one- and three-month mortality). In patients with COVID19 infection (n=547), mortality at one and three months was respectively 36.4% (174/478) and 46.7% (228/488). Conclusions: Early mortality has not improved over the two decades and remains high. KBP-2020-CPHG study was performed during COVID-19 pandemic, which may have generated delays in diagnosis and limited access to care and hospital. Early mortality at one and three months concerned mostly men, mean age nearly 70 y-o, adenocarcinoma, metastatic disease and frail patients. This confirms the potential value of LC screening program in a targeted population. [Table: see text]

Published
2022
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7. High-flow nasal oxygen a safe, efficient treatment for COVID-19 patients not in an ICU

Author

David Marquette, Stéphane Jouneau, Christine Lineau, Mathieu Lederlin, Marie Langelot, Jean Louis Bizec, Françoise Martin, Charles Ricordel, Tiphaine Guy, Audrey Créac'hcadec, Baptiste Arnouat, A. Salé, Centre hospitalier Bretagne Atlantique (Morbihan) (CHBA), CHU Pontchaillou [Rennes], Chemistry, Oncogenesis, Stress and Signaling (COSS), Université de Rennes (UR)-CRLCC Eugène Marquis (CRLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire Traitement du Signal et de l'Image (LTSI), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Institut National de la Santé et de la Recherche Médicale (INSERM)-CRLCC Eugène Marquis (CRLCC)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), and HEP, INSPIRE

Subjects
Pulmonary and Respiratory Medicine, 2019-20 coronavirus outbreak, Critical Care, Coronavirus disease 2019 (COVID-19), viruses, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Pneumonia, Viral, Betacoronavirus, 03 medical and health sciences, 0302 clinical medicine, Research Letter, Cannula, Humans, Medicine, 030212 general & internal medicine, Pandemics, ComputingMilieux_MISCELLANEOUS, [SDV.IB] Life Sciences [q-bio]/Bioengineering, Noninvasive Ventilation, SARS-CoV-2, business.industry, fungi, Oxygen Inhalation Therapy, virus diseases, COVID-19, medicine.disease, respiratory tract diseases, 3. Good health, Pneumonia, 030228 respiratory system, Respiratory failure, Anesthesia, Noninvasive ventilation, [SDV.IB]Life Sciences [q-bio]/Bioengineering, Coronavirus Infections, business, High flow
Abstract

The new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes coronavirus disease (COVID-19), now recognised by the WHO as a pandemic, emerged in late 2019 in China [1]. Patients infected with SARS-CoV-2 can develop severe pneumonia and respiratory failure, which often require treatment in intensive care units (ICU) in Western European countries [2]. Oxygen therapy and supportive care are still the main forms of therapy for SARS-CoV-2 pneumonia until suitable anti-infective therapies become available., SARS-CoV2 infected patients with non-hypercapnic acute hypoxemic respiratory failure can benefit from HFNO outside an ICU. The technique appears to be safe for HCWs and could well liberate critical ICU resources.

Published
2020
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8. Prevalence and risk factors for COPD in farmers: a cross-sectional controlled study

Author

Bruno Degano, Jean-Jacques Laplante, S. Guillot, Stéphane Jouneau, Marc Puyraveau, Jean-Charles Dalphin, Patrick Berger, F. Rannou, Alicia Guillien, David Marquette, Elisabeth Monnet, Thibaud Soumagne, Frédéric Mauny, Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC (EA 3181) (CEF2P / CARCINO), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), CHU Pontchaillou [Rennes], Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Physiopathologie de la réactivite bronchique et vasculaire, Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Mutualité sociale agricole de Franche-Comté, Mutualité sociale agricole, Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC), Physiopathologie cardiovasculaire et prévention, Département de physiologie, Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC (UR 3181) (CEF2P / CARCINO), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), and Laboratoire Chrono-environnement (UMR 6249) (LCE)

Subjects
Adult, Male, Pulmonary and Respiratory Medicine, Vital capacity, medicine.medical_specialty, Swine, Cross-sectional study, [SDV]Life Sciences [q-bio], Vital Capacity, Pulmonary disease, Poultry, Pulmonary Disease, Chronic Obstructive, 03 medical and health sciences, FEV1/FVC ratio, 0302 clinical medicine, Risk Factors, Forced Expiratory Volume, Occupational Exposure, Prevalence, medicine, Animals, Humans, 030212 general & internal medicine, Animal Husbandry, Lung function, Aged, 2. Zero hunger, COPD, Farmers, business.industry, Smoking, Case-control study, food and beverages, Middle Aged, medicine.disease, Crop Production, Obstructive lung disease, Agricultural Workers' Diseases, respiratory tract diseases, Cross-Sectional Studies, 030228 respiratory system, Case-Control Studies, Physical therapy, Cattle, Female, France, business, Demography
Abstract

There are conflicting data regarding the magnitude and determinants of chronic obstructive pulmonary disease (COPD) risk in farmers.In a cross-sectional study of 917 nonfarming working controls and 3787 farmers aged 40–75 years, we assessed respiratory symptoms, tobacco exposure, job history (without direct exposure measurement) and lung function. COPD was defined by the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criterion (post-bronchodilator forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) 1/FVC The prevalence (95% CI) of COPD according to the GOLD criterion was 5.1% (4.4–5.8%) and 2.9% (1.8–4.0%) in farmers and controls, respectively (p=0.005), and 3.1% (2.5–3.6%) and 1.5% (0.7–2.3%), respectively, for the LLN criterion (pThe prevalence of COPD in farmers is higher than in nonfarming working controls, and depends on the farming activity, the region and the criterion used to define COPD.

Published
2016
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9. IV Immunoglobulin Might Be Considered as a First-line Treatment of Severe Interstitial Lung Disease Associated With Polymyositis

Author

Vincent Lesire, David Marquette, Sylvain Marchand-Adam, Patrice Diot, D. Carmier, and Elisabeth Diot

Subjects
Pulmonary and Respiratory Medicine, Pathology, medicine.medical_specialty, biology, business.industry, Interstitial lung disease, Critical Care and Intensive Care Medicine, medicine.disease, Polymyositis, First line treatment, biology.protein, medicine, Antibody, Cardiology and Cardiovascular Medicine, business
Published
2011
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