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Abstract Background Surgical site infections (SSIs) are one of the most common healthcare-associated infections and preventable complication of surgical procedure; continue to threaten public health with significant effects on the patients and health care human and financial resources. Therefore, this study aimed to determine the incidence of SSIs, risk factors and common microorganisms associated with SSI and assess the practice of antimicrobial use in women following Caesarean Section (CS) at Queen Elizabeth Central Hospital (QECH). Methods This was a hospital-based quantitative prospective study design involving pregnant women who underwent a CS between February, 2023 and July, 2023 at QECH with 30 day-follow-ups. Wound specimens (wound swabs) were collected from all infected CS wounds and processed at QECH main laboratory, and susceptibility testing was conducted using the Kirby-Bauer disk diffusion method with results reported only as susceptible, intermediate, or resistant and the collected data was analyzed using Stata. Results The overall cumulative incidence of SSI recorded at QECH during the study period was 9.61% (20 cases out of 208). Of these, 19 (95%) of them reported superficial SSI following CS. The mean age was 26.1 years with a standard deviation of 6.2. All pregnant women who underwent for CS received antibiotic prophylaxis. This study revealed that 138 (66.35%) patients received both preoperative antibiotics (ceftriaxone) and post-CS antibiotics without knowing the specific bacterial organism isolated. This study revealed that ruptured membrane had twice the incidence of SSIs compared to intact membrane (χ2 = 2.0922), though not statistically significant. The majority of patients with SSIs (n = 12, 60%) were readmitted and 5 (25%) out of 20 with SSIs had antimicrobial resistance following susceptibility testing. Staphylococcus aureus was the most common organism (3, 60%) and other bacterial isolates included were Enterobacteriaceae and Acinetobacter baumanni. Conclusion The incidence of SSIs and inappropriate antimicrobial use following CS remains a challenge at QECH. Therefore, due to increased number of SSIs following CS with relative emergence of AMR ensure intensive infection prevention and control practices, establishing AMS program and routine surveillance of SSIs at QECH.

Summary: Background: Nearly all transmitted/founder (T/F) HIV-1 are CCR5 (R5)-tropic. While previous evidence suggested that CXCR4 (X4)-tropic HIV-1 are transmissible, virus detection and characterization were not at the earliest stages of acute infection. Methods: We identified an X4-tropic T/F HIV-1 in a participant (40700) in the RV217 acute infection cohort. Coreceptor usage was determined in TZM-bl cell line, NP-2 cell lines, and primary CD4+ T cells using pseudovirus and infectious molecular clones. CD4 subset dynamics were analyzed using flow cytometry. Viral load in each CD4 subset was quantified using cell-associated HIV RNA assay and total and integrated HIV DNA assay. Findings: Participant 40700 was infected by an X4 tropic HIV-1 without CCR5 using ability. This participant experienced significantly faster CD4 depletion compared to R5 virus infected individuals in the same cohort. Naïve and central memory (CM) CD4 subsets declined faster than effector memory (EM) and transitional memory (TM) subsets. All CD4 subsets, including the naïve, were productively infected. Increased CD4+ T cell activation was observed over time. This X4-tropic T/F virus is resistant to broadly neutralizing antibodies (bNAbs) targeting V1/V2 and V3 regions, while most of the R5 T/F viruses in the same cohort are sensitive to the same panel of bNAbs. Interpretation: X4-tropic HIV-1 is transmissible through mucosal route in people with wild-type CCR5 genotype. The CD4 subset tropism of HIV-1 may be an important determinant for HIV-1 transmissibility and virulence. Funding: Institute of Human Virology, National Institutes of Health, Henry M. Jackson Foundation for the Advancement of Military Medicine.

In advanced photonics, there is a growing interest in piezochromic luminescent materials that exhibit multicolor switching, driven by their potential applications in optical recording, memory, and sensors. Here, the piezochromic behavior of 2,4,6‐triphenylpyrylium tetrachloroferrate (Py‐FeCl4) under high pressures from 0 to 9 GPa is reported. The observed multicolor changing properties of Py‐FeCl4 (yellow–orange–red–maroon–black) are found to be fully reversible upon decompression to ambient conditions. The mechanism of Py‐FeCl4 piezochromism is investigated via Raman, infrared, and UV–vis spectroscopy combined with powder X‐ray Diffraction. The absence of structural phase transitions as well as the abrupt shifts of bandgap values together with characteristic Raman and IR peaks within 0‐9 GPa suggests that the Py‐FeCl4 multicoloring switching behavior is driven by an electron transfer between the inorganic FeCl4− anion and the organic pyrylium cation. The obtained results demonstrate that Py‐FeCl4 dye is a good candidate for developing high‐pressure sensing technologies designed to function in extreme environments. Moreover, due to the inherent role of molecular‐structure relationships in the pyrylium salt's photophysical properties, findings suggest the potential discovery of piezochromic behavior in other pyrylium compounds.

Abstract The signed value and unsigned salience of reward prediction errors (RPEs) are critical to understanding reinforcement learning (RL) and cognitive control. Dorsomedial prefrontal cortex (dMPFC) and insula (INS) are key regions for integrating reward and surprise information, but conflicting evidence for both signed and unsigned activity has led to multiple proposals for the nature of RPE representations in these brain areas. Recently developed RL models allow neurons to respond differently to positive and negative RPEs. Here, we use intracranially recorded high frequency activity (HFA) to test whether this flexible asymmetric coding strategy captures RPE coding diversity in human INS and dMPFC. At the region level, we found a bias towards positive RPEs in both areas which paralleled behavioral adaptation. At the local level, we found spatially interleaved neural populations responding to unsigned RPE salience and valence-specific positive and negative RPEs. Furthermore, directional connectivity estimates revealed a leading role of INS in communicating positive and unsigned RPEs to dMPFC. These findings support asymmetric coding across distinct but intermingled neural populations as a core principle of RPE processing and inform theories of the role of dMPFC and INS in RL and cognitive control.

There are numerous cardiac imaging modalities which aid in the diagnosis and management of coronary artery disease (CAD). Each modality has variable efficacy in detecting stenosis and stratifying risk among those with CAD. Clinicians must evaluate these methods in light of their patients’ clinical presentations, to choose the most appropriate imaging technique. Understanding the unique benefits and indications of each modality aids in the selection of high-value imaging. Following is a review of the available cardiac imaging methods for the identification and risk stratification of CAD.

The role of spirituality has become increasingly important in the field of social work, especially when considering a holistic approach. Religion and spirituality are used to guide beliefs and actions and give meaning and purpose to life. This research, situated at an Evangelical Christian University, explored why it is critical for practitioners to be spiritually equipped when working with those in need and their perceptions of the importance of faith to practice and identity. This study identified seven themes: how spirituality assists practitioners in dealing with information and events in the social work field and the importance of spirituality in providing strength, hope, guidance, self-preservation, a positive example for clients, and an opportunity to share the love of God. This research contributes to the future of social work education.

Social work curricula frequently lack the inclusion of Religion, Faith and Spirituality (RFS). While faith and religious beliefs are often connected with professional calling, values, and practice, the integration of faith and social work practice is uncommon. This research explored the experiences of students in a Master of Social Work (MSW) program that integrated Christian faith throughout the curriculum and its effects on their spiritual understanding, development, and identity. A qualitative study of student responses was completed to gain insight into the impact of the curriculum on students’ spiritual growth, understanding, and views regarding the ethical integration of Christian faith and practice. The research findings confirmed the value of faith integration in social work education and helped inform the development of more effective curricula in faith-based settings. The results of this study may benefit other evangelical Christian universities seeking to increase students’ personal growth in faith as well as competencies and ethical practices as social workers.

Abstract Flexible behavior requires gating mechanisms that encode only task-relevant information in working memory. Extant literature supports a theoretical division of labor whereby lateral frontoparietal interactions underlie information maintenance and the striatum enacts the gate. Here, we reveal neocortical gating mechanisms in intracranial EEG patients by identifying rapid, within-trial changes in regional and inter-regional activities that predict subsequent behavioral outputs. Results first demonstrate information accumulation mechanisms that extend prior fMRI (i.e., regional high-frequency activity) and EEG evidence (inter-regional theta synchrony) of distributed neocortical networks in working memory. Second, results demonstrate that rapid changes in theta synchrony, reflected in changing patterns of default mode network connectivity, support filtering. Graph theoretical analyses further linked filtering in task-relevant information and filtering out irrelevant information to dorsal and ventral attention networks, respectively. Results establish a rapid neocortical theta network mechanism for flexible information encoding, a role previously attributed to the striatum.

Urban vegetation is a nature-based solution for cooling cities. Under global warming and urban population growth, it is essential to optimize urban vegetation configuration in the urban area to bring maximum cooling benefit. This paper reviews 85 optimized urban vegetation configuration studies published from 2010 to 2020 to provide an insight into the most effective vegetation configuration for urban heat mitigation. Patterns and preferences in methods and the optimized greenery configurations are comprehensively analyzed. The results indicate that size, quantity, and layout of urban green space and the physiological characteristics and spatial arrangement of urban vegetation significantly influence their cooling effect. Additionally, two other research gaps were identified. First, more research needs to be done in southern hemisphere cities experiencing rapid urbanization and severe impacts of extreme weather. Second, a comprehensive method for quantifying interactions and cumulative effects of natural and artificial factors in the urban environment is required. Future study needs a holistic understanding of the interactive effects of vegetation spatial distribution on urban environment and climate for a more accurate analysis of optimal cooling greening layouts in large urban areas at multi-scales.

Objectives To identify and evaluate clinical approaches to whole person assessment (WPA) that are translatable to family medicine regarding feasibility, quality and alignment with theoretical models of whole person care (WPC).Design Systematic literature review.Data sources MEDLINE, CINAHL, PsycINFO and ATLA Religion databases were searched through 9 March 2020, with additional handsearches.Eligibility criteria English language clinical assessments of multiple domains; which involve patient–clinician interaction and are translatable to general practice (GP); from the fields of medicine, allied health, nursing, mental health and pastoral care. Tools designed for single diseases or symptoms, for outcome rather than clinical assessment or with outdated classification systems were excluded.Data extraction and synthesis We appraised the quality of included papers using Johanna Briggs’ Institute Checklists and Terwee’s criteria for validation studies. Clinical assessments’ alignment with theoretical WPC, feasibility for adaptation to GP and quality were examined. We analysed extracted data using framework synthesis.Results Searches retrieved 7535 non-duplicate items. Fifty-nine were included after screening, describing 42 WPA methods and representing multiple disciplines, purposes and formats. All included assessments aligned partially with models of WPC, but most did not adequately encompass all aspects of WPC. Robustness varied significantly and was often inadequately described. We judged none of the identified assessments to be ideal as a multipurpose WPA in GP. Some could be used for specific purposes, such as elicitation of patient perspectives or complexity assessment.Conclusions While no WPAs were found that were sufficient for broad implementation in GP, some approaches may be suitable with adaptation and evaluation. Strengths of existing approaches could inform WPA development in future.PROSPERO registration number CRD42020164417.

When it is deposited in the ocean, volcanic ash has the potential to release iron and other nutrients into surface water to stimulate ocean productivity. In the western South Pacific Ocean (SPO), one of the most important volcanic ash deposition regions, occasional widespread transport of volcanic ash may supply the nutrients not only locally around source islands but also within the wider the western SPO, accompanied by phytoplankton response. Through a comparative analysis of satellite and reanalysis data for the past 19 years (2004–2022), this study reveals that four explosive volcanic eruptions, Rabaul volcano, Papua New Guinea (October, 2006), Ambae volcano, Vanuatu (July, 2018), Ulawun volcano, Papua New Guinea (June, 2019), and Hunga volcano, Tonga (January, 2022), had the most strong stratospheric injection (>15 km) and mass loading of volcanic materials over the wider the western SPO (covering an area of >765,000 km2). The transport of 2006, 2018, 2019 volcanic emissions, was not likely associated with significant ash deposition over the western SPO. However, the Hunga eruption led to the deposition of ash-laden volcanic plumes over a wide area (~2,000 km from source), and was followed by the increase in chlorophyll-a concentrations (Chl-a) in the region (~70% increase). Minor changes related to other nutrient sources (e.g., hydrothermal input) suggest a link between the increase in Chl-a and 2022 Hunga ash falls over the western SPO. Our results indicate that volcanic ash deposition has implications for phytoplankton productivity in the western SPO, and highlights the need for further research into understanding how nutrient supply alleviated limitations of phytoplankton at the community level.

Summary: Assays detecting blood transcriptome changes are studied for infectious disease diagnosis. Blood-based RNA alternative splicing (AS) events, which have not been well characterized in pathogen infection, have potential normalization and assay platform stability advantages over gene expression for diagnosis. Here, we present a computational framework for developing AS diagnostic biomarkers. Leveraging a large prospective cohort of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and whole-blood RNA sequencing (RNA-seq) data, we identify a major functional AS program switch upon viral infection. Using an independent cohort, we demonstrate the improved accuracy of AS biomarkers for SARS-CoV-2 diagnosis compared with six reported transcriptome signatures. We then optimize a subset of AS-based biomarkers to develop microfluidic PCR diagnostic assays. This assay achieves nearly perfect test accuracy (61/62 = 98.4%) using a naive principal component classifier, significantly more accurate than a gene expression PCR assay in the same cohort. Therefore, our RNA splicing computational framework enables a promising avenue for host-response diagnosis of infection. Motivation: Host-based response assays (HRAs) can often diagnose infectious disease earlier and more precisely than pathogen-based tests. However, the role of RNA alternative splicing (AS) in HRAs remains unexplored, as existing HRAs are restricted to gene expression signatures. We report a computational framework for the identification, optimization, and evaluation of blood AS-based diagnostic assay development for infectious disease. Using SARS-CoV-2 infection as a case study, we demonstrate the improved accuracy of AS biomarkers for COVID-19 diagnosis when compared against six reported transcriptome signatures and when implemented as a microfluidic PCR diagnostic assay.

Objective: To evaluate the prognostic significance of detectable circulating cell-free DNA (cfDNA) BRAF V600E/K mutations in patients with advanced melanoma enrolled in a clinical trial without BRAF-targeted therapy. Patients and Methods: BRAF V600E/K mutation status was determined on archived tissue and pretreatment stored plasma from 149 patients with unresectable stage IV melanoma who were enrolled between May 5, 2010 and May 2, 2014 in the North Central Cancer Treatment Group/Alliance N0879 randomized phase 2 clinical trial. Results were reported as presence or absence of cfDNA BRAF V600E/K detection of assay vs tissue. Progression-free survival (PFS) and overall survival (OS) were assessed for patients with and without detectable BRAF mutation. Results: In total, 63 of 149 (42.3%) patients had BRAF V600E/K results for tissue and blood, and 20 of 63 (31.7%) patients had tissue-diagnosed mutant BRAF. Of these, 11 of 20 (55.0%) patients had detectable plasma cfDNA BRAF. Among patients with tissue-mutant BRAF V600E/K, PFS and OS were shorter for those with corresponding cfDNA mutations (PFS, 5.8 vs 12.0 months; P=.051; OS, 9.2 vs 27.1 months; P=.054). Our assay demonstrated sensitivity of 55% (95% CI, 0.322 to 0.768), specificity of 97.7% (95% CI, 0.932 to 1.000), positive predictive value of 91.7% (95% CI, 0.760 to 1.000), and negative predictive value of 82.4% (95% CI, 0.719 to 0.928). Conclusion: In advanced melanoma, detectable cfDNA BRAF V600E/K mutation is present in about half the patients with stage IV with BRAF-mutant melanoma tumor tissue and appears to confer a poorer prognosis when detectable. Given the poorer prognosis, cfDNA can be used to risk-stratify patients with metastatic melanoma in practice or clinical trials.Trial Registration: clinicaltrials.gov Identifier: NCT00976573

Neurophysiological studies in humans and nonhuman primates have revealed movement representations in both the contralateral and ipsilateral hemispheres. Inspired by clinical observations, we ask if this bilateral representation differs for the left and right hemispheres. Electrocorticography was recorded in human participants during an instructed-delay reaching task, with movements produced with either the contralateral or ipsilateral arm. Using a cross-validated kinematic encoding model, we found stronger bilateral encoding in the left hemisphere, an effect that was present during preparation and was amplified during execution. Consistent with this asymmetry, we also observed better across-arm generalization in the left hemisphere, indicating similar neural representations for right and left arm movements. Notably, these left hemisphere electrodes were centered over premotor and parietal regions. The more extensive bilateral encoding in the left hemisphere adds a new perspective to the pervasive neuropsychological finding that the left hemisphere plays a dominant role in praxis.

Abstract Background Evaluating relationships between avian populations and their habitat is important for understanding the biology of these species and for management decisions that improve the effectiveness of restoration practices. We investigated how habitat variation along a disturbance gradient affected the abundance of three insectivorous bird species, White-bellied Antbird (Myrmeciza longipes), Barred Antshrike (Thamnophilus doliatus), and Pale-breasted Spinetail (Synallaxis albescens) in a Neotropical dry forest remnant in central Colombia. Methods The study area, which is located in Magdalena Valley, is under ecological restoration after the construction of the “El Quimbo” hydroelectric dam, with a gradient of habitat conditions, from relatively advanced secondary growth to recently disturbed areas. We conducted bird surveys and quantified the habitat conditions from June 2018 to June 2019. We compared the relative abundance of the birds among the three zones with increasing disturbance and modeled the relationship between the bird abundance with the micro- and landscape-habitat conditions, with Poisson generalized linear model regression. Results The relative abundance of the three bird species varied according to the habitat features and disturbance level. The abundance of White-bellied Antbirds was higher in forests and thickets than shrubland fragments; Barred Antshrike was more abundant in shrubland and thickets than in forest fragments, and Pale-breasted Spinetail had the highest abundance in shrubland and the lowest in forest fragments. The abundance of both White-bellied Antbird and Pale-breasted Spinetail did not differ among zones with different levels of disturbance, while the abundance of Barred Antshrike decreased in zones with more disturbance. Conclusions There were significant differences in the habitat relationships of the three understory insectivorous species along the disturbance gradient, although these species were within the same trophic group. These bird species preferred different stages of habitat succession and responded to different habitat and landscape features. Increasing forest fragment areas and decreasing the amount of edge would be useful restoration priorities for these and other similar avian species in this study area.

Pursuant to the Paris Agreement, China committed itself to peak its carbon emissions by around 2030 and to increase the non-fossil share of primary energy to 20% at the same time. The government has supported the international agreement by setting and strengthening the domestic policy targets for an earlier peak and faster reduction, aiming to contain the average global temperature increase to well below 2 °C. We develop a Kaya Inequality method to assess the time of peak and pace of reduction of China's energy-related CO2 emissions based on the national energy policy targets for 2030. We find that, despite the minor fluctuations, the current plateau essentially represents the peak emissions and should enter a phase of steady decline by around 2025, given current trends in energy consumption and decarbonization. Such developments would be consistent with the strengthened national policy target to achieve 50% of renewable power generation by 2030. However, the basic policy targets – a 20% share of non-fossil energy and 6 Gtce in total energy consumption by 2030 – would be insufficient to peak carbon emissions by around 2030. The synergy and interplay between domestic policy target setting and international climate commitments shed light on the need to elevate national climate ambitions under the Paris Agreement and beyond.

Rare earth elements (REEs) are a major constituent of many advanced materials in the information and telecommunication industries, as well as the renewable and energy efficiency sectors. REEs are enablers of speed, performance, durability, and low carbon emissions in these industries. They are required in everyday applications because of their unique chemical and physical properties. Given the rise in environmental concerns and consequent demand for REEs and the limited locations where REEs can be sourced, there is a very high risk of supply disruption.Despite the threat of REE supply risk and its environmental and economic significance, an in-depth examination of the environmental impact and benefits of sustainable consumption of these metals in Australia, as in many other parts of the world, holistically and systematically is lacking, particularly regarding improvement in resource efficiency strategies. Most previous work on REEs has focused either on the politico-economic conflicts over supply and distribution, or the environmental and social impacts of its production and has not holistically examined this problem, as a system.This paper provides a review of REEs' sustainable consumption in Australia. The study highlights Circular Economy (CE) as a scientifically plausible picture of sustainable management strategy to help address the adverse impacts of resource (REEs) shortages while achieving maximum environmental benefits. It provides answers to how sustainable are the current strategies of REEs consumption and how this can be enhanced from a CE perspective. A comprehensive CE framework was developed, followed by an illustrative example of CE as a tool for sustainability management and a practical implementation strategy to close the material loop and improve resource efficiency.

Background: We measured Human Immunodeficiency (HIV) incidence, retention, and assessed risk factors for seroconversion among two previously unreported cohorts of men who have sex with men (MSM) and Transgender Women (TGW) in Bangkok, Thailand between 2017 and 2019. Methods: We conducted an 18-month prospective cohort study of HIV-uninfected Thai cisgender men and TGW aged between 18 and 35 years who reported sex with men in the past six months and at least one additional risk factor for HIV infection. HIV and syphilis testing and computer-based behavioral questionnaires were administered at each visit. We utilized Poisson regression to calculate HIV incidence rates. A survival random forest model identified the most predictive risk factors for HIV sero-conversion and then used in a survival regression tree model to elucidate hazard ratios for individuals with groups of selected risk factors. Cox proportional hazards (pH) regression evaluated the strength of association between individual covariates and risk of sero-conversion. Findings: From April 2017-October 2019, 1,184 participants were screened, 167 were found ineligible, and 1,017 enrolled. Over the 18-month study, visit retention was 93·4% (95% CI 91·6%–94·8%) and HIV incidence was 3·73 per 100 person-years (95% CI 2·79–5·87). Utilizing survival regression tree modeling, those who were 18–20 years of age, reported sexual attraction to mostly or only men, and had five or more lifetime sexual partners were 4·9 times more likely to seroconvert compared to other cohort participants. Factors associated with HIV incidence utilizing Cox pH regression included sexual attraction to mostly or only men (adjusted hazard ratio (aHR) 14·9 (95% CI 20·1–107·9), younger age (18–19 years, aHR 10·88 (95% CI 4·12–28·7), five or greater lifetime sexual partners (aHR 2·0, 95%CI 1·1–3·6), inconsistent condom use with casual partners (aHR 2·43, 95% CI 1·3–4·5), and prior HIV testing (adjusted HR 2·0, 95% CI 1·1–3·5). Interpretation: Interpretation HIV incidence remains high among Bangkok-based MSM and TGW. These key populations expressed high interest in participating in efficacy evaluation of future prevention strategies and had high retention in this 18 month study. Funding: Funding US National Institute of Allergy and Infectious Diseases (NIAID), Division of AIDS Interagency Agreements (DAIDS) and U.S. Department of the Army.

The sequencing of viral genomes provides important data for the prevention and control of foot-and-mouth disease (FMD) outbreaks. Sequence data can be used for strain identification, outbreak tracing, and aiding the selection of the most appropriate vaccine for the circulating strains. At present, sequencing of FMD virus (FMDV) relies upon the time-consuming transport of samples to well-resourced laboratories. The Oxford Nanopore Technologies' MinION portable sequencer has the potential to allow sequencing in remote, decentralised laboratories closer to the outbreak location. In this study, we investigated the utility of the MinION to generate sequence data of sufficient quantity and quality for the characterisation of FMDV serotypes O, A, Asia 1. Prior to sequencing, a universal two-step RT-PCR was used to amplify parts of the 5′UTR, as well as the leader, capsid and parts of the 2A encoding regions of FMDV RNA extracted from three sample matrices: cell culture supernatant, tongue epithelial suspension and oral swabs. The resulting consensus sequences were compared with reference sequences generated on the Illumina MiSeq platform. Consensus sequences with an accuracy of 100% were achieved within 10 and 30 min from the start of the sequencing run when using RNA extracted from cell culture supernatants and tongue epithelial suspensions, respectively. In contrast, sequencing from swabs required up to 2.5 h. Together these results demonstrated that the MinION sequencer can be used to accurately and rapidly characterise serotypes A, O, and Asia 1 of FMDV using amplicons amplified from a variety of different sample matrices.

The potential ergogenic effects of vitamin D (vitD) in high performing athletes has received considerable attention in the literature and media. However, little is known about non-supplemented university athletes and students residing at a higher latitude. This study aimed to investigate the effects of vitD (biochemical status and dietary intake) on exercise performance in UK university athletes and sedentary students. A total of 34 athletes and 16 sedentary controls were studied during the spring and summer months. Serum vitD status and sunlight exposure were assessed using LC-MS/MS and dosimetry, respectively. Muscular strength of the upper and lower body was assessed using handgrip and knee extensor dynamometry (KE). Countermovement jump (CMJ) and aerobic fitness were measured using an Optojump and VO2max test, respectively. Statistical analysis was performed using paired/ independent t-tests, ANCOVA and Pearson/ Spearman correlations, depending on normality. VitD status increased significantly over the seasons, with athletes measuring higher status both in spring (51.7±20.5 vs. 37.2±18.9 nmol/L, p = 0.03) and summer (66.7±15.8 vs 55.6±18.8 nmol/L, p = 0.04) when compared to controls, respectively. Notably, 22% of the subjects recruited were vitD deficient during the spring term only (50nmol/l) group (p = 0.055) and a lower VO2 max (p = 0.05) in the spring and summer term (p = 0.05 and p = 0.01, respectively). However, an ANCOVA test showed no significant difference detected for either CMJ or VO2max following adjustments for co-variates. In conclusion, we provide novel information on the vitD status, dietary intake, physical fitness and sunlight exposure of UK young adults across two separate seasons, for which there is limited data at present.

Conferência sobre o cantor/compositor folk Pete Seeger, realizada como resultado da pesquisa e biografia desenvolvida pelo pesquisador David King Dunaway (UNM). A data de apresentação remete a efeméride dos 100 anos do nascimento do artista. Evoca a trajetória de P. Seeger, contextualizando sua atuação na política norte-americana, a partir das canções de autoria, na ação de engajamento pelos direitos civis. Simultaneamente, aponta para as memórias do pesquisador, na construção de seu percurso metodológico e resultados do trabalho tematizado pela vida do biografado.

To reduce the spread of COVID-19, governments across the world enacted various levels of “shelter-in-place” policies, leading to a notable reduction in urban mobility. To understand the relationship between policy implementation and mobility effects, we use Apple COVID-19 Mobility Trends Reports to assess how urban travel, by mode, changed in response to public policy. The data were used to statistically evaluate and visualize the changes in urban mobility patterns across four regions: Sydney, London, Phoenix, and Pune, which reflect the global nature of the pandemic and the local nature of policy responses. The results provide insights into how policies can receive a starkly varied response from communities across global regions.

Background: In neuroblastoma, genetic alterations in ATRX, define a distinct poor outcome patient subgroup. Despite the need for new therapies, there is a lack of available models and a dearth of pre-clinical research. Methods: To evaluate the impact of ATRX loss of function (LoF) in neuroblastoma, we utilized CRISPR-Cas9 gene editing to generate neuroblastoma cell lines isogenic for ATRX. We used these and other models to identify therapeutically exploitable synthetic lethal vulnerabilities associated with ATRX LoF. Findings: In isogenic cell lines, we found that ATRX inactivation results in increased DNA damage, homologous recombination repair (HRR) defects and impaired replication fork processivity. In keeping with this, high-throughput compound screening showed selective sensitivity in ATRX mutant cells to multiple PARP inhibitors and the ATM inhibitor KU60019. ATRX mutant cells also showed selective sensitivity to the DNA damaging agents, sapacitabine and irinotecan. HRR deficiency was also seen in the ATRX deleted CHLA-90 cell line, and significant sensitivity demonstrated to olaparib/irinotecan combination therapy in all ATRX LoF models. In-vivo sensitivity to olaparib/irinotecan was seen in ATRX mutant but not wild-type xenografts. Finally, sustained responses to olaparib/irinotecan therapy were seen in an ATRX deleted neuroblastoma patient derived xenograft. Interpretation: ATRX LoF results in specific DNA damage repair defects that can be therapeutically exploited. In ATRX LoF models, preclinical sensitivity is demonstrated to olaparib and irinotecan, a combination that can be rapidly translated into the clinic. Funding: This work was supported by Christopher's Smile, Neuroblastoma UK, Cancer Research UK, and the Royal Marsden Hospital NIHR BRC.

Background: Since the coronavirus disease 2019 (COVID-19) outbreak was first reported in December 2019, many independent trials have been planned that aim to answer similar questions. Tools allowing researchers to review studies already underway can facilitate collaboration, cooperation and harmonisation. The Infectious Diseases Data Observatory (IDDO) has undertaken a living systematic review (LSR) to provide an open, accessible and frequently updated resource summarising characteristics of COVID-19 study registrations. Methods: Review of all eligible trial records identified by systematic searches as of 3 April 2020 and initial synthesis of clinical study characteristics were conducted. In partnership with Exaptive, an open access, cloud-based knowledge graph has been created using the results. Results: There were 728 study registrations which met eligibility criteria and were still active. Median (25th, 75th percentile) sample size was 130 (60, 400) for all studies and 134 (70, 300) for RCTs. Eight lower middle and low income countries were represented among the planned recruitment sites. Overall 109 pharmacological interventions or advanced therapy medicinal products covering 23 drug categories were studied. Majority (57%, 62/109) of them were planned only in one study arm, either alone or in combination with other interventions. There were 49 distinct combinations studied with 90% (44/49) of them administered in only one or two study arms. The data and interactive platform are available at https://iddo.cognitive.city/. Conclusions: Baseline review highlighted that the majority of investigations in the first three months of the outbreak were small studies with unique treatment arms, likely to be unpowered to provide solid evidence. The continued work of this LSR will allow a more dependable overview of interventions tested, predict the likely strength of evidence generated, allow fast and informative filtering of relevant trials for specific user groups and provide the rapid guidance needed by investigators and funders to avoid duplication of efforts.

The ability to identify periods of heightened seizure risk could enable new treatments for patients with epilepsy. Here, the authors describe long term EEG recordings from 37 patients which allow them to identify multi-day fluctuations in interictal activity.

How does the human brain rapidly process incoming information in working memory? In growing divergence from a single-region focus on the prefrontal cortex (PFC), recent work argues for emphasis on how distributed neural networks are rapidly coordinated in support of this central neurocognitive function. Previously, we showed that working memory for everyday “what,” “where,” and “when” associations depends on multiplexed oscillatory systems, in which signals of different frequencies simultaneously link the PFC to parieto-occipital and medial temporal regions, pointing to a complex web of sub-second, bidirectional interactions. Here, we used direct brain recordings to delineate the frontoparietal oscillatory correlates of working memory with high spatiotemporal precision. Seven intracranial patients with electrodes simultaneously localized to prefrontal and parietal cortices performed a visuospatial working memory task that operationalizes the types of identity and spatiotemporal information we encounter every day. First, task-induced oscillations in the same delta-theta (2–7 Hz) and alpha-beta (9–24 Hz) frequency ranges previously identified using scalp electroencephalography (EEG) carried information about the contents of working memory. Second, maintenance was linked to directional connectivity from the parietal cortex to the PFC. However, presentation of the test prompt to cue identity, spatial, or temporal information changed delta-theta coordination from a unidirectional, parietal-led system to a bidirectional, frontoparietal system. Third, the processing of spatiotemporal information was more bidirectional in the delta-theta range than was the processing of identity information, where alpha-beta connectivity did not exhibit sensitivity to the contents of working memory. These findings implicate a bidirectional delta-theta mechanism for frontoparietal control over the contents of working memory.

In this first, double-blind, randomized, placebo-controlled exploratory trial, we evaluate the efficacy and safety of incobotulinumtoxinA and feasibility of using kinematic tremor assessment to aid in the planning of muscle selection in a multicenter setting. Reproducibility of the planning technology to other clinical sites was explored. In this trial (NCT02207946), patients with upper-limb essential tremor (ET) were randomized 2:1 to a single treatment cycle of incobotulinumtoxinA or placebo. A tremor kinematic analytics investigational device was used to define a customized muscle set for injection, related to the pattern of the wrist, forearm, elbow, and shoulder tremor for each patient, and the incobotulinumtoxinA dose per muscle (total ≤ 200 U). Fahn–Tolosa–Marin (FTM) Part B motor performance score, Global Impression of Change Scale (GICS), and kinematic analysis-based efficacy evaluations were assessed. Thirty patients were randomized (incobotulinumtoxinA, n = 19; placebo, n = 11). FTM motor performance scores showed greater improvement with incobotulinumtoxinA versus placebo at Week 4 (p= 0.003) and Week 8 (p= 0.031). The physician-rated GICS score indicated improvement with incobotulinumtoxinA versus placebo at Week 4 (p < 0.05). IncobotulinumtoxinA also decreased accelerometric hand-tremor amplitude versus placebo from baseline to Week 4 (p= 0.004) and Week 8 (p < 0.001), with persistent tremor reduction up to 24 weeks post-injection. IncobotulinumtoxinA produced a slight and transient reduction of maximal grip strength versus placebo; two patients reported localized finger muscle weakness. Customized incobotulinumtoxinA injections decreased tremor severity and improved hand motor function in patients with upper-limb ET after a single injection cycle, with a favorable tolerability profile. The study showed that tremor kinematic analytics technology could be successfully scaled for use in other clinical sites.

The protection of a boat canal at the western entrance of Tangier Island, Virginia, located in the lower Chesapeake Bay, is investigated using different structural alternatives. The existing entrance channel is oriented 45 deg with respect to the local shoreline, and exposed directly to the lower Bay without any protection. The adjacent shoreline has experienced progressive erosion in recent decades by flooding due to severe storms and waves. To protect the western entrance of the channel and shoreline, five different jetty and spur combinations were proposed to reduce wave energy in the lee of jetties. Environmental forces affecting the proposed jettied inlet system are quantified using the Coastal Modeling System, consisting of a spectral wave model and a depth-averaged circulation model with sediment transport calculations. Numerical simulations were conducted for design wave conditions and a 50-year return period tropical storm at the project site. Model results show a low crested jetty of 170-m length connecting to the north shore at a 45-deg angle, and a short south spur of 25-m long, provide adequate wave-reduction benefits among the five proposed alternatives. The model simulation indicates this alternative has the minimum impact on sedimentation around the structured inlet and boat canal.

Este artigo discute o desenvolvimento da história oral nos Estados Unidos e como isto levou o campo a se tornar interdisciplinar em modos interessantes e úteis. Traça as suas origens no século XVII e explica o seu estabelecimento como um método (coleta de dados orais), um subcampo da história (historiografia oral) e um recurso para professores, comunidades e pesquisadores de todos os tipos (história oral). O autor descreve as suas aplicações práticas em outros campos, como a antropologia, a educação/ensino, os estudos étnicos/etno-históricos/americanos, o folclore, a gerontologia, o direito, a história literária, os estudos e a produção de mídia e os estudos das mulheres e de gênero. Os manuais de história oral também são discutidos neste artigo, que termina com uma atualização sobre como os historiadores orais estão enfrentando a nova e anti-intelectual postura do Presidente Trump e a sua agenda de direita. Esse fato é realmente novo: aparecerá no próximo mês na Oral History Newsletter da Associação de História Oral. Palavras-chave: História Oral, EUA, Coleta de Dados Orais, Contação de história.

This article discusses the development of oral history in the United States and how this has led the field to becoming interdisciplinary in interesting and useful ways. It traces its origins in the 17th century and explains its establishment as method (oral data collection), a subfield of history (oral historiography) and a resource for teachers, communities, and researchers of all kinds (oral history). The author describes the practical applications of oral history in other fields such as anthropology, education/ teaching, ethnic studies/ethnohistory/American studies, folklore, gerontology, legal studies, literary history, media studies and media production, and women and gender studies. A review of oral history guides is also given. The article ends with an update on how oral historians are coping with the new, anti-intellectual orientation of President Trump and his right-wing agenda. Keywords: Oral History. USA. Oral Data Collection. History-Telling.

Taxicabs are ubiquitous in cities throughout the world, and the industry is going through regulatory change with the growth of app-based services. In the United States, where taxicabs are typically regulated locally, licenses determine where taxis can pick up passengers. This means that for trips that end outside of licensed boundaries taxicabs are prohibited from picking up passengers and are forced to make “deadhead” return trips. This research estimates empty taxi travel associated with spatial restrictions on passenger trip origins in New York City. In 2012, New York introduced a special taxi category intended to improve taxi access in areas of the city considered underserved by taxicabs. The new green taxicabs, as they are called, can drop off passengers anywhere in the city but are restricted from picking up passengers in the central business districts and at any of the region’s airports. Using detailed trip data for each taxi ride, we estimate that up to 500,000 kilometers per week of deadhead travel are associated with restrictions on pick up locations, and more than 20 percent of all green taxicab trips end in an area where the driver is prohibited from picking up a new passenger.

The history of South Africa serves as a natural experiment in how a changing institutional environment impacts corporate structure. Based on institutional theory, we anticipate higher performance through emulating successful strategies or through restructuring consistent with mimetic isomorphism. Conversely, coercive isomorphism results from restructuring driven by regulation, and we anticipate that they are associated with lower performance. To examine these relationships, we consider divestment by South African firms over two periods, using mixed methods. We find tentative support for our predictions, and we outline implications for policymakers, as well as for management research and practice.

Specimen data in taxonomic literature are among the highest quality primary biodiversity data. Innovative cybertaxonomic journals are using workflows that maintain data structure and disseminate electronic content to aggregators and other users; such structure is lost in traditional taxonomic publishing. Legacy taxonomic literature is a vast repository of knowledge about biodiversity. Currently, access to that resource is cumbersome, especially for non-specialist data consumers. Markup is a mechanism that makes this content more accessible, and is especially suited to machine analysis. Fine-grained XML (Extensible Markup Language) markup was applied to all (37) open-access articles published in the journal Zootaxa containing treatments on spiders (Order: Araneae). The markup approach was optimized to extract primary specimen data from legacy publications. These data were combined with data from articles containing treatments on spiders published in Biodiversity Data Journal where XML structure is part of the routine publication process. A series of charts was developed to visualize the content of specimen data in XML-tagged taxonomic treatments, either singly or in aggregate. The data can be filtered by several fields (including journal, taxon, institutional collection, collecting country, collector, author, article and treatment) to query particular aspects of the data. We demonstrate here that XML markup using GoldenGATE can address the challenge presented by unstructured legacy data, can extract structured primary biodiversity data which can be aggregated with and jointly queried with data from other Darwin Core-compatible sources, and show how visualization of these data can communicate key information contained in biodiversity literature. We complement recent studies on aspects of biodiversity knowledge using XML structured data to explore 1) the time lag between species discovry and description, and 2) the prevelence of rarity in species descriptions.

Background: Recent years have seen a surge in projects that produce large volumes of structured, machine-readable biodiversity data. To make these data amenable to processing by generic, open source “data enrichment” workflows, they are increasingly being represented in a variety of standards-compliant interchange formats. Here, we report on an initiative in which software developers and taxonomists came together to address the challenges and highlight the opportunities in the enrichment of such biodiversity data by engaging in intensive, collaborative software development: The Biodiversity Data Enrichment Hackathon. Results: The hackathon brought together 37 participants (including developers and taxonomists, i.e. scientific professionals that gather, identify, name and classify species) from 10 countries: Belgium, Bulgaria, Canada, Finland, Germany, Italy, the Netherlands, New Zealand, the UK, and the US. The participants brought expertise in processing structured data, text mining, development of ontologies, digital identification keys, geographic information systems, niche modeling, natural language processing, provenance annotation, semantic integration, taxonomic name resolution, web service interfaces, workflow tools and visualisation. Most use cases and exemplar data were provided by taxonomists. One goal of the meeting was to facilitate re-use and enhancement of biodiversity knowledge by a broad range of stakeholders, such as taxonomists, systematists, ecologists, niche modelers, informaticians and ontologists. The suggested use cases resulted in nine breakout groups addressing three main themes: i) mobilising heritage biodiversity knowledge; ii) formalising and linking concepts; and iii) addressing interoperability between service platforms. Another goal was to further foster a community of experts in biodiversity informatics and to build human links between research projects and institutions, in response to recent calls to further such integration in this research domain. Conclusions: Beyond deriving prototype solutions for each use case, areas of inadequacy were discussed and are being pursued further. It was striking how many possible applications for biodiversity data there were and how quickly solutions could be put together when the normal constraints to collaboration were broken down for a week. Conversely, mobilising biodiversity knowledge from their silos in heritage literature and natural history collections will continue to require formalisation of the concepts (and the links between them) that define the research domain, as well as increased interoperability between the software platforms that operate on these concepts.

Background: We aimed to assess the association of sleep with metabolic syndrome in the 2013/2014 National Health and Nutrition Examination Survey (NHANES). Methods: Sample size included 2737 out of 2013 and 2014 NHANES surveys. Cross-sectional study of metabolic syndrome and sleep duration was conducted. Metabolic syndrome was defined according to NCEP ATPIII (National Cholesterol Education Program Adult Treatment Panel III) criteria. Metabolic syndrome severity score was calculated based on actual measurement of each component, adjusted for sex and race. The generalized additive model (GAM) was built to assess the smooth relationship between metabolic syndrome/metabolic syndrome severity score and sleep duration. Adjustment of models were done for age, sex, race, and sitting time. The value of effective degree of freedom (EDF) formed by the GAM model shows the degree of curvature of the relationship. A value of 1 for EDF is translated as the linear shape of relationship. Values larger than one denote a more complex relationship between the response variable and the predicting one. Results: There was a U-shaped association between sleep duration and metabolic syndrome in univariable GAM (EDF = 2.43, p = 0.06) and multivariable GAM (EDF = 2.03, p = 0.20). The lowest risk of metabolic syndrome was observed in people sleeping 7 hours/night. There was a significant U-shaped association between sleep duration and metabolic syndrome severity score in multivariable GAM (EDF = 2.94, p = 0.0004). Similarly, the lowest mean metabolic syndrome severity score was observed in people sleeping 7 hours/night. There was an effect modification of sex and sleep duration indicating strong U-shaped relationship of metabolic syndrome severity score and sleep duration in women (EDF = 3.43, p = 0.00002) and semi-linear association in men (EDF = 1.76, p = 0.04). Conclusion: Short and long sleep duration was associated with higher risk of metabolic syndrome and higher scores of metabolic syndrome severity score in women. Short sleep duration was associated with higher risk of metabolic syndrome and higher scores of metabolic syndrome severity score in men.

Vietnam is highly vulnerable to the impacts of climate change, particularly in poor coastal communities. While external climate change projects have been conducted in some coastal provinces, including Ha Tinh, there is a lack of local education programs to enhance communities’ awareness and adaptive capacity to cope with climate change. Therefore, a community education program is proposed to help Ha Tinh locals adapt to climate change. The aim of this paper is to present a brief literature review, including: identifying key concepts, overviewing global climate change, analysing climate change and climate change adaptation in Vietnam, as well as theoretical frameworks.

Background: South Africa has a disproportionately high freight transport demand owing to industrial development far from ports, low domestic beneficiation and improper modal use. Historical freight transport policy supported primary economic development, failing to preempt the changing economic structure and the resulting freight transport needs, resulting in excessive transport costs and externalities. Objectives: To share the macroeconomic freight transport challenges revealed by South Africa’s Logistics Barometer, and to identify key interventions to address these. Method: Freight flows are modelled by disaggregating the national input–output model into 83 commodity groupings and 372 geographical areas, culminating in a 30-year forecast at 5-year intervals for three scenarios, followed by distance-decay gravity modelling to determine freight flows. Logistics costs are calculated by relating these flows to the costs of fulfilling associated logistic functions. Results: Long-distance transport remains the largest general freight typology and is, due to inefficient macro logistics design, extremely costly, both in terms of intrinsic and extrinsic costs. Conclusion: South Africa’s freight task will grow 2.5-fold by 2043. Logistics and externality costs are already untenable at current levels. The development of domestic intermodal solutions will support the drive towards sustainable freight mobility.

This paper investigates the suitable location for an intermodal inland container terminal (IICT) in the city of Cape Town. A container market segmentation approach is used to project growth for container volumes over a 30-year period for all origin and destination pairings on a geographical district level in an identified catchment area. The segmentation guides the decision on what type of facility is necessary to fulfil capacity requirements in the catchment area and will be used to determine the maximum space requirements for a future IICT. Alternative sites are ranked from most suitable to least suitable using multi-criteria analysis, and preferred locations are identified. Currently, South Africa’s freight movement is dominated by the road sector. Heavy road congestion is thus prevalent at the Cape Town Container Terminal (CTCT). The paper proposes three possible alternative sites for an IICT that will focus on a hub-and-spoke system of transporting freight.

This paper highlights the first attempt by researchers at Stellenbosch University to model freight flows between and for 17 countries in sub-Saharan Africa (SSA). The model will be informed by and linked to the South African surface Freight Demand Model (FDM) given these dimensions. By analysing and collating available datasets and developing a freight flow model, a better understanding of freight movements between countries can be obtained and then used for long-term planning efforts. A simple methodology is envisaged that will entail a high-level corridor classification that links a major district in the country with a similar district in another country. Existing trade data will be used to corroborate new base-year economic demand and supply volumetric data that will be generated from social accounting matrices for each country. The trade data will also provide initial flow dynamics between countries that will be refined according to the new volumes. The model can then generate commodity-level corridor flows between SSA countries, and between SSA countries and the rest of the world, as well as intra-country rural and metropolitan flows, using a gravity-based modelling approach. This article outlines efforts to harmonise trade data between the 17 countries identified, as well as between these countries and the rest of the world as a first step towards developing a freight demand model for sub-Saharan Africa.

The purpose of this study is to quantify the marginal external costs associated with freight transport in South Africa. Six cost elements are included as externality cost items, namely, costs related to accidents, emissions, roadway land availability, policing, noise and congestion. Inputs in the calculations were a gravity-oriented freight flow model, a road transport cost model, actual transport costs for other modes, a warehousing cost survey, an inventory delay calculation and various national sources of information such as accident statistics and government budgets. Estimation techniques resulted in advances for externality cost measurement in South Africa. The quantification of the cost elements will be used to update the South African Freight Demand Model. The results show that the cost of transportation would have been 20% more if external factors were taken into account. The marginal rates of externalities can be used to develop scenarios based on alternative choices for South Africa's freight transport infrastructure configuration.

International relief and development agencies consistently rank among the largest evangelical organizations, and in recent decades, they have gained increased exposure and influence within the greater humanitarian community. World Vision, the largest evangelical agency, is also the largest Christian humanitarian organization in the world. Themes of politics and culture wars have led many to scholars to categorize American evangelicals into distinct conservative and liberal parties. Yet the history of American evangelicals’ humanitarianism demonstrates how they often resisted such dichotomies. As evangelical humanitarian agencies expanded exponentially over the past five decades, they came to embrace a “holistic gospel” that helped shape evangelical mission debates concerning the relationship between evangelism and social action; they engaged international evangelicals that forced Americans to reconsider their own categories; and many modeled a practical ecumenism that allowed evangelicals to expand beyond a limited subculture to work alongside other religious and even secular NGOs. While other evangelical progressives fragmented over identity politics or remained tethered to small alterative communities, the leading aid agencies have achieved broad support across evangelicalism, making them some of the most influential voices.

This study analysed the 2009/10 formal teacher-pupil mentoring scheme at Blackwater Community School (BCS), Lismore, Co. Waterford in the Republic of Ireland. Twenty three teachers voluntarily mentored 220 pupils sitting state examinations as part of the scheme, which was monitored by two mentoring coordinators. Benefits and drawbacks of the scheme are discussed under the topics of quality in the mentoring relationship, organisation and perceived impact of the scheme. It was found that the most beneficial outcome of the scheme was the development of positive relationships between teachers and pupils involved.

PremiseThis essay is an elaboration of a paper read at the Imagining Bodies conference at Tallinn University in 2010, where the author considered differing meanings of the concept of productivity, and market force’s impact on dance in Estonia. The premise was that a cultural tourist might be able to view and describe cultural production in Estonia in novel and possibly productive ways, because of his geographic and social displacement. After making notes while touring in Estonia, during autumn and winter of 2009/2010, on his observations of similarities and differences between how dance is created and funded in Estonia and California, the author gathered them into a travelogue and subjected them to a variety of cultural, economic and political critiques.ObservationsThe scale and direction of cultural production in Estonia and California are vastly different but capital market forces foreground similar resource allocations in dance production:Women provide the central core of the social infrastructure of the Estonian Dance and dance education. It is this self-subsidized labour pool, operating at discounted labour costs, that provides the social infrastructure that is the primary dance resource for the nextgeneration of Estonian dancers. The social good that dance produces is often defined as a positive externality, secondary to internal/cash transactions, operating outside of the capital economy and probably not included in measures of the gross domestic product of the nation. Externalizing the costs of dance education and production allows for “free riding” by individuals and institutions that profit from the goods dance practices produce for the country without making personal investment. Dance is further subject to what William Baumol calls the “productivity lag” in the performing arts wherein dance, because it requires a fixed number of labour hours toproduce and perform, seems cost more than the consumer goods that have become easier and quicker to produce since industrialization.Training citizens’ bodies to be moved, and to move together, to dance and perform acts that create a common good, seems to be an externality – outside the bounds of market forces, something that is obfuscated and not talked about. These definitions lead us to profligately expend the social capital it takes to create and maintain the organizational infrastructures that sustain communities.Conclusions The peoples of Estonia, from the sea-islands to the inland lakes, northern towns, and southern hills, are producing a rich and diverse cultural product. The culture of Estonia is second only to its natural beauty as an economic draw for tourism. The export of Estonian art has the potential to advertise and solidify the country’s presence in the international business and political arenas. While touring with the Koolitants festival the author, a foreigner, was given the extraordinary gift of experiencing the great energy and potential of the young dancers of the Estonian countryside and was able to see the dedicated work and commitment of the adults who are the most vibrant part of the infrastructure for moving the work of young artists from Estonia into the world. However, the infrastructure of dance in Estonia is being pushed to produce at, orperhaps beyond, its carrying capacity and signs of strain are showing around the edges. The social infrastructure is rich, but risks losing cohesion due to burnout of key players. Young dancers often look outside of Estonia to find fulfilment in their work, adding topopulation stagnation and brain drain. The fear is that without timely and investments in the social and physical infrastructure of dance, Estonia will not be able to remain competitive in the global arts market.The solution is an offset by skill and ability that small dance organizations have shown in leveraging the resources they have invested into local movements that make impacts on a national scale. Creating a strategic policy of cash investments in dance culture will mean that the dances they produce will be thoughtful reflections on the history and future of their nation.

We review the three most widely used XML schemas used to mark-up taxonomic texts, TaxonX, TaxPub and taXMLit. These are described from the viewpoint of their development history, current status, implementation, and use cases. The concept of “taxon treatment” from the viewpoint of taxonomy mark-up into XML is discussed. TaxonX and taXMLit are primarily designed for legacy literature, the former being more lightweight and with a focus on recovery of taxon treatments, the latter providing a much more detailed set of tags to facilitate data extraction and analysis. TaxPub is an extension of the National Library of Medicine Document Type Definition (NLM DTD) for taxonomy focussed on layout and recovery and, as such, is best suited for mark-up of new publications and their archiving in PubMedCentral. All three schemas have their advantages and shortcomings and can be used for different purposes.

This paper discusses how we intend to take forward the vision of a Bibliography of Life in the ViBRANT project. The underlying principle of the Bibliography is to provide taxonomists and others with a freely accessible bibliography covering the whole of life. Such a bibliography has been achieved for specific study areas within taxonomy, but not for “life” as a whole.The creation of such a comprehensive tool has been hindered by various social and technical issues. The social concerns focus on the willingness of users to contribute to the Bibliography. The technical concerns relate to the architecture required to deliver the Bibliography. These issues are discussed in the paper and approaches to addressing them within the ViBRANT project are described, to demonstrate how we can now seriously consider building a Bibliography of Life. We are particularly interested in the potential of the resulting tool to improve the quality of bibliographic references. Through analysing the large number of references in the Bibliography we will be able to add metadata by resolving known issues such as geographical name variations. This should result in a tool that will assist taxonomists in two ways. Firstly, it will be easier for them to discover relevant literature, especially pre-digital literature; and secondly, it will be easier for them to identify the canonical form for a citation.The paper also covers related issues relevant to building the tool in ViBRANT, including implementation and copyright, with suggestions as to how we could address them.

Purpose: Adjuvant high-dose-rate brachytherapy (HDRBT) offers advantages over low dose rate brachytherapy (LDRBT), although there are little data on local tumor control and treatment related toxicity. We report outcome in patients with primary, recurrent, and metastatic extremity and superficial trunk soft tissue sarcoma. Material and methods: Eleven patients (12 sites) with intermediate or high grade sarcoma were treated with adjuvant HDRBT following surgical resection. Patients were treated at 3.4 Gy fractions delivered twice daily to a total dose of 34 Gy (1 patient received 9 fractions). Results: With median follow-up of 20.8 months, 1 patient developed a local recurrence. 2-year local control and overall survival are 89% and 71%, respectively. Wound complications occurred in 3 sites. Two of the wound complications developed in the area of previous external beam radiotherapy (EBRT). Conclusion: Surgical resection followed by HDRBT is associated with excellent early local tumor control and acceptable wound complication.

Climate change is emerging as the main driver of current and future climate-related risks for small islands. These risks include sea level rise, stronger tropical cyclones, and changing rainfall patterns. While there is now high confidence in the scientific community that the present change in climate is anthropogenic in nature compared to the Earth’s geologic history of natural variability, there is a need for more detailed evaluations of the relationships between humans and the climate. As a human activity affected by climate change, tourism is in need of such analyses since current positivist analytical tools are inadequate for evaluating the complexity of such interactions. This paper reviews the literature, scientific frameworks, and methodological epistemologies used to analyse human community relationships to natural environments and their applicability in small island tourism environments that are impacted by climate change in the Philippines. Political ecology emerges as a potent and appropriate framework since climate change adaptation planning processes for island tourism are inherently political. The paper advances the use of political ecology for climate change adaptation to grapple with the equally complex phenomena of island tourism urbanisation and climate change, thereby contributing to the discourse in three research areas.

This research paper presents a case study of the island of Boracay, Philippines, utilising a political ecology approach to climate change adaptation. The research finds that the island’s political ecology, especially the relationships among stakeholders, is strained. This creates challenges for various urban planning processes that require good working relationships. Climate change is expected to highlight these divisions as interactions among stakeholders (fulfilling zoning ordinance obligations, climate change adaptation- compliant land use plans, etc.) are dependent on good stakeholder relations. Stakeholders realise that climate change is real and that sea level rise is already challenging existing zoning ordinances on urban beach development. However, this realisation must be integrated into political decision-making processes involving tourism stakeholders. The research also shows that the political ecology approach and methodology is applicable to studying the dynamics of climate change adaptation and tourism urbanisation on small islands.