Search

Your search keyword '"David Hoyt"' showing total 134 results
Start Over Author "David Hoyt"
134 results on '"David Hoyt"'

1. Incidence and outcomes of Merkel cell carcinoma related to Merkel cell polyomavirus status in Iceland in 1981-2023Capsule Summary

Author

Maria Vygovska, MD, David Hoyt, BS, Ashley M. Snyder, PhD, MPH, Thorarinn Jonmundsson, MSc, Ashley Khouri, BS, Dev Ram Sahni, MD, MHA, Jonathan Ungar, MD, Jesse M. Lewin, MD, Nicholas Gulati, MD, PhD, Robert G. Phelps, MD, Vikram N. Sahni, MD, Jane M. Grant-Kels, MD, Helgi Sigurdsson, MD, Jon Gunnlaugur Jonasson, MD, and Jonas A. Adalsteinsson, MD, PhD

Subjects
basal cell carcinoma, Iceland, Merkel cell carcinoma, photodamage, polyomavirus, squamous cell carcinoma, Dermatology, RL1-803
Abstract

Background: Impact of Merkel cell polyomavirus (MCPyV) associated Merkel cell carcinoma (MCC) has not been assessed in the Icelandic population, nor in a whole population elsewhere. Objectives: The primary objective was to assess trends in the incidence of MCC in Iceland and the association with MCPyV. Secondary objectives aimed to analyze MCC outcomes. Methods: In this retrospective cohort study, patients diagnosed with MCC between 1981 and 2021 were identified from the Icelandic Cancer Registry. Patients were separated into 2 groups based on MCPyV immunochemistry staining. Age-standardized incidence was calculated and Joinpoint analysis was used to assess incidence trends. A Cox proportional hazards model was used to assess survival differences between the 2 groups. Results: Overall incidence of MCC increased from 0.015 to 0.26 per 100,000 persons, though the incidence of MCPyV positive cases recently decreased while negative cases increased. MCPyV negative tumors were associated with sun exposure (P

Published
2024
Full Text
View/download PDF

2. Evidence of cryptic methane cycling and non-methanogenic methylamine consumption in the sulfate-reducing zone of sediment in the Santa Barbara Basin, California

Author

Sebastian Jian Ernst Krause, Jiarui Liu, David J. Yousavich, DeMarcus Robinson, David Hoyt, Qianhui Qin, Frank Wenzhoefer, Felix Janssen, David Valentine, and Tina Treude

Abstract

The recently discovered cryptic methane cycle in the sulfate-reducing zone of marine and wetland sediments couples methylotrophic methanogenesis to anaerobic oxidation of methane (AOM). Here we present evidence of cryptic methane cycling activity within the upper regions of the sulfate-reducing zone, along a depth transect within the Santa Barbara Basin, off the coast of California, USA. The top 0–20 cm of sediment from each station was subjected to geochemical analyses and radiotracer incubations using 35S-SO42-, 14C-mono-methylamine, and 14C- CH4 to find evidence of cryptic methane cycling. Methane concentrations were consistently low (~3 to ~16 µM) across the depth transect, despite AOM rates increasing with decreasing water depth (from max 0.05 nmol cm-3 d-1 at the deepest station to max 1.8 nmol cm-3 d-1 at the shallowest station). Porewater sulfate concentrations remained high (~23 mM to ~29 mM), despite the detection of sulfate reduction activity from 35S-SO42- incubations with rates up to 134 nmol cm-3 d-1. Metabolomic analysis showed that substrates for methanogenesis (i.e., acetate, methanol and methylamines) were mostly below the detection limit in the porewater, but some samples from the 1–2 cm depth section showed non-quantifiable evidence of these substrates, indicating their rapid turnover. Estimated methanogenesis from mono-methylamine ranged from 0.2 nmol to 0.5 nmol cm-3 d-1. Discrepancies between the rate constants (K1) of methanogenesis (from 14C- mono-methylamine) and AOM (from either 14C- mono-methylamine-derived 14C-CH4 or from directly injected 14C-CH4) suggest the activity of a separate, concurrent metabolic process directly metabolizing mono-methylamine to inorganic carbon. We conclude that the results presented in this work show strong evidence of cryptic methane cycling occurring within the top 20 cm of sediment in the Santa Barbara Basin. The rapid cycling of carbon between methanogenesis and methanotropy likely prevents major build-up of methane in the sulfate-reducing zone. Furthermore, our data suggest that methylamine is utilized by both methanogenic archaea capable of methylotrophic methanogenesis and non-methanogenic microbial groups. We hypothesize that sulfate reduction is responsible for the additional methylamine turnover but further investigation is needed to elucidate this metabolic activity.

Published
2023

4. Elucidating Drought-Tolerance Mechanisms in Plant Roots through 1H NMR Metabolomics in Parallel with MALDI-MS, and NanoSIMS Imaging Techniques

Author

Linnea K. Honeker, Gina A. Hildebrand, Jane D. Fudyma, L. Erik Daber, David Hoyt, Sarah E. Flowers, Juliana Gil-Loaiza, Angelika Kübert, Ines Bamberger, Christopher R. Anderton, John Cliff, Sarah Leichty, Roya AminiTabrizi, Jürgen Kreuzwieser, Lingling Shi, Xuejuan Bai, Dusan Velickovic, Michaela A. Dippold, S. Nemiah Ladd, Christiane Werner, Laura K. Meredith, and Malak M. Tfaily

Subjects
Environmental Chemistry, General Chemistry
Published
2022
Full Text
View/download PDF

5. Drought induces soil microbial stress responses and emissions of volatile organic compounds in an artificial tropical rainforest

Author

Linnea Honeker, Giovanni Pugliese, Johannes Ingrisch, Jane Fudyma, Juliana Gil-Loaiza, Elizabeth Carpenter, Esther Singer, Gina Hildebrand, Lingling Shi, David Hoyt, Jordan Krechmer, Megan Claflin, Christian Ayala-Ortiz, Viviana Freire-Zapata, Eva Pfannerstill, L. Daber, Michaela Dippold, Jürgen Kreuzwieser, Jonathan Williams, S. Ladd, Christiane Werner, Malak Tfaily, and Laura Meredith

Abstract

Drought impacts microbial carbon cycling, and thus the fate of carbon in soils. Carbon allocation to energy via CO2 producing respiration and to biosynthesis via volatile organic compound (VOC) emissions both represent consequent carbon loss to the atmosphere, although only the former is well studied. Here, we examined drought impacts on carbon allocation by soil microbes to CO2 and VOCs using position-specific 13C-labeled pyruvate and multi-omics in an artificial tropical rainforest. During drought, 13C-VOCs efflux increased, driven by increased production and buildup of intermediate metabolites due to decreased interconnectivity between central carbon metabolism pathways, and 13C-CO2 efflux decreased, driven by an overall decrease in microbial activity. However, internal carbon allocation to energy relative to biosynthesis did not change, signifying maintained energy demand toward biosynthesis of VOCs and drought-stress induced biosynthesis pathways. Therefore, while carbon loss to the atmosphere via CO2 decreases during drought, carbon loss via VOCs may increase.

Published
2022
Full Text
View/download PDF

6. Spatial metabolic profiling in roots reveals plant specific responses to drought at the Biosphere 2 tropical rainforest

Author

Linnea K. Honeker, Gina A. Hildebrand, Jane D. Fudyma, L. Erik Daber, David Hoyt, Sarah E. Flowers, Juliana Gil-Loaiza, Angelika Kübert, Ines Bamberger, Christopher R. Anderton, John Cliff, Sarah Leichty, Roya AminiTabriz, Jürgen Kreuzwieser, Lingling Shi, Xuejuan Bai, Dusan Velickovic, Michaela A. Dippold, S. Nemiah Ladd, Christiane Werner, Laura K. Meredith, and Malak M. Tfaily

Published
2022
Full Text
View/download PDF

8. Older Blood Is Associated With Increased Mortality and Adverse Events in Massively Transfused Trauma Patients: Secondary Analysis of the PROPPR Trial

Author

Allison R. Jones, Rakesh P. Patel, Marisa B. Marques, John P. Donnelly, Russell L. Griffin, Jean-Francois Pittet, Jeffrey D. Kerby, Shannon W. Stephens, Stacia M. DeSantis, John R. Hess, Henry E. Wang, John B. Holcomb, Charles E. Wade, Deborah J. del Junco, Erin E. Fox, Nena Matijevic, Jeanette Podbielski, Angela M. Beeler, Barbara C. Tilley, Sarah Baraniuk, Hongjian Zhu, Joshua Nixon, Roann Seay, Savitri N. Appana, Hui Yang, Michael O. Gonzalez, Lisa Baer, Yao-Wei W. Wang, Brittany S. Hula, Elena Espino, An Nguyen, Nicholas Pawelczyk, Kisha D. Arora-Nutall, Rishika Sharma, Jessica C. Cardenas, Elaheh Rahbar, Tyrone Burnett, David Clark, Gerald van Belle, Susanne May, Brian Leroux, David Hoyt, Judy Powell, Kellie Sheehan, Alan Hubbard, Adam P. Arkin, Jeanne Callum, Bryan A. Cotton, Laura Vincent, Timothy Welch, Tiffany Poole, Evan G. Pivalizza, Sam D. Gumbert, Yu Bai, James J. McCarthy, Amy Noland, Rhonda Hobbs, Eileen M. Bulger, Patricia Klotz, Lindsay Cattin, Keir J. Warner, Angela Wilson, David Boman, Nathan White, Andreas Grabinsky, Jennifer A. Daniel-Johnson, Mitchell J. Cohen, Rachael A. Callcut, Mary Nelson, Brittney Redick, Amanda Conroy, Marc P. Steurer, Preston C. Maxim, Eberhard Fiebig, Joanne Moore, Eireen Mallari, Peter Muskat, Jay A. Johannigman, Bryce R.H. Robinson, Richard D. Branson, Dina Gomaa, Christopher Barczak, Suzanne Bennett, Patricia M. Carey, Christopher N. Miller, Helen Hancock, Carolina Rodriguez, Kenji Inaba, Jay G. Zhu, Monica D. Wong, Michael Menchine, Kelly Katzberg, Sean O. Henderson, Rodney McKeever, Ira A. Shulman, Janice M. Nelson, Christopher W. Tuma, Cheryl Y. Matsushita, Thomas M. Scalea, Deborah M. Stein, Cynthia K. Shaffer, Christine Wade, Anthony V. Herrera, Seeta Kallam, Sarah E. Wade, Samuel M. Galvagno, Magali J. Fontaine, Janice M. Hunt, Rhonda K. Cooke, Timothy C. Fabian, Jordan A. Weinberg, Martin A. Croce, Suzanne Wilson, Stephanie Panzer-Baggett, Lynda Waddle-Smith, Sherri Flax, Karen J. Brasel, Pamela Walsh, David Milia, Allia Nelson, Olga Kaslow, Tom P. Aufderheide, Jerome L. Gottschall, Erica Carpenter, Terence O’Keeffe, Laurel L. Rokowski, Kurt R. Denninghoff, Daniel T. Redford, Deborah J. Novak, Susan Knoll, Patrick L. Bosarge, Albert T. Pierce, Carolyn R. Williams, Martin A. Schreiber, Jennifer M. Watters, Samantha J. Underwood, Tahnee Groat, Craig Newgard, Matthias Merkel, Richard M. Scanlan, Beth Miller, Sandro Rizoli, Homer Tien, Barto Nascimento, Sandy Trpcic, Skeeta Sobrian-Couroux, Marciano Reis, Adic Pérez, Susan E. Belo, Lisa Merkley, and Connie Colavecchia

Subjects
Adult, Male, medicine.medical_specialty, Critical Illness, Logistic regression, law.invention, 03 medical and health sciences, 0302 clinical medicine, Trauma Centers, Randomized controlled trial, law, Secondary analysis, Internal medicine, Odds Ratio, medicine, Humans, Blood Transfusion, Hospital Mortality, 030212 general & internal medicine, Adverse effect, business.industry, 030208 emergency & critical care medicine, Odds ratio, Middle Aged, Revised Trauma Score, Confidence interval, Blood Preservation, Emergency Medicine, Injury Severity Score, Female, business
Abstract

Study objective The transfusion of older packed RBCs may be harmful in critically ill patients. We seek to determine the association between packed RBC age and mortality among trauma patients requiring massive packed RBC transfusion. Methods We analyzed data from the Pragmatic, Randomized Optimal Platelet and Plasma Ratios trial. Subjects in the parent trial included critically injured adult patients admitted to 1 of 12 North American Level I trauma centers who received at least 1 unit of packed RBCs and were predicted to require massive blood transfusion. The primary exposure was volume of packed RBC units transfused during the first 24 hours of hospitalization, stratified by packed RBC age category: 0 to 7 days, 8 to 14 days, 15 to 21 days, and greater than or equal to 22 days. The primary outcome was 24-hour mortality. We evaluated the association between transfused volume of each packed RBC age category and 24-hour survival, using random-effects logistic regression, adjusting for total packed RBC volume, patient age, sex, race, mechanism of injury, Injury Severity Score, Revised Trauma Score, clinical site, and trial treatment group. Results The 678 patients included in the analysis received a total of 8,830 packed RBC units. One hundred patients (14.8%) died within the first 24 hours. On multivariable analysis, the number of packed RBCs greater than or equal to 22 days old was independently associated with increased 24-hour mortality (adjusted odds ratio [OR] 1.05 per packed RBC unit; 95% confidence interval [CI] 1.01 to 1.08): OR 0.97 for 0 to 7 days old (95% CI 0.88 to 1.08), OR 1.04 for 8 to 14 days old (95% CI 0.99 to 1.09), and OR 1.02 for 15 to 21 days old (95% CI 0.98 to 1.06). Results of sensitivity analyses were similar only among patients who received greater than or equal to 10 packed RBC units. Conclusion Increasing quantities of older packed RBCs are associated with increased likelihood of 24-hour mortality in trauma patients receiving massive packed RBC transfusion (≥10 units), but not in those who receive fewer than 10 units.

Published
2019
Full Text
View/download PDF

10. Ruth Benedict

Author

Joyce Appleby, Elizabeth Covington, David Hoyt, Michael Latham, and Allison Sneider

Published
2020
Full Text
View/download PDF

12. John Locke

Author

Joyce Appleby, Elizabeth Covington, David Hoyt, Michael Latham, and Allison Sneider

Published
2020
Full Text
View/download PDF

15. Introduction

Author

Joyce Appleby, Elizabeth Covington, David Hoyt, Michael Latham, and Allison Sneider

Published
2020
Full Text
View/download PDF

16. Karl Marx

Author

Joyce Appleby, Elizabeth Covington, David Hoyt, Michael Latham, and Allison Sneider

Published
2020
Full Text
View/download PDF

17. Knowledge and Postmodernism in Historical Perspective

Author

Joyce Appleby, Elizabeth Covington, Allison Sneider, Michael Latham, and David Hoyt

Subjects
White (horse), John dewey, Philosophy, Perspective (graphical), Theology, Adam smith, Condorcet method, Postmodernism, Rene descartes
Abstract

Includes extracts from the works of: Francis Bacon, Rene Descartes, John Locke, Adam Smith, David Hume, Emmanuel Kant, Marquis de Condorcet, Ernst Cassirer, Alexis de Tocqueville, Karl Marx, Charles Baudelaire, Friedrich Nietzsche, Max Weber, Norman Birnbaum, John Dewey, Ruth Benedict, Claude Levi-Strauss, Clifford Geertz, Theodor Adorno and Max Horkheimer, Thomas Kuhn, Alasdair MacIntyre, Paul Ricoeur, Hayden White, Jacques Derrida, Richard Rorty, Cornel West, David Harvey, Jurgen Habermas, Craig Calhoun, Seyla Benhabib.

Published
2020
Full Text
View/download PDF

22. Francis Bacon

Author

Joyce Appleby, Elizabeth Covington, David Hoyt, Michael Latham, and Allison Sneider

Published
2020
Full Text
View/download PDF

29. Cornel West

Author

Joyce Appleby, Elizabeth Covington, David Hoyt, Michael Latham, and Allison Sneider

Published
2020
Full Text
View/download PDF

30. Immanuel Kant

Author

Joyce Appleby, Elizabeth Covington, David Hoyt, Michael Latham, and Allison Sneider

Published
2020
Full Text
View/download PDF

31. Thomas Kuhn

Author

Joyce Appleby, Elizabeth Covington, David Hoyt, Michael Latham, and Allison Sneider

Published
2020
Full Text
View/download PDF

36. Karl Marx (1847): The German Ideology

Author

David Hoyt, Michael Latham, Joyce Appleby, Allison Sneider, and Elizabeth Covington

Subjects
German, Philosophy, media_common.quotation_subject, language, Ideology, Religious studies, language.human_language, media_common
Published
2020
Full Text
View/download PDF

37. David Harvey

Author

Joyce Appleby, Elizabeth Covington, David Hoyt, Michael Latham, and Allison Sneider

Published
2020
Full Text
View/download PDF

43. Hayden White

Author

Joyce Appleby, Elizabeth Covington, David Hoyt, Michael Latham, and Allison Sneider

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results