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This study explores the potential impact of natural soil on concrete crack self-healing in sub-surface structures. Three types of pre-cracked cement mortar samples were prepared for laboratory experiments, with some samples inoculated with bacterial healing agents, others supplemented with nutrients to attract indigenous soil bacteria, and plain mortar served as controls. The samples were placed within saturated soil under two conditions: slightly organic natural soil and sterilised soil. After 100 days, crack closure was evaluated through microscopic inspection, water absorption tests, and SEM-EDX scanning. The results indicated calcite precipitation on crack surfaces across all samples, but with varying ratios of crack closure (16%–81%). Notably, most samples incubated in natural soil exhibited an overall increase (up to 59.4%) in healing ratio compared to those in sterilised soil, highlighting the potential of indigenous soil microorganisms and their microbial activity in enhancing the biogenic mineral precipitation and thus protecting sub-surface concrete structures.

Purpose: The Australian Genomics Cardiovascular Disorders Flagship was a national multidisciplinary collaboration. It aimed to investigate the feasibility of genome sequencing (GS) and functional genomics to resolve variants of uncertain significance (VUS) in the clinical management of patients and families with cardiomyopathies, primary arrhythmias, and congenital heart disease (CHD). Methods: Between April 2019 and December 2021, 600 probands meeting cardiovascular disorder criteria from 17 cardiology and genetics clinics across Australia were enrolled in the Flagship and underwent GS. The Flagship adopted a tiered approach to GS analysis. Tier 1 analysis assessed genes with established clinical validity for each cardiovascular condition. Tier 2 analysis assessed lesser-evidenced research-based genes. Tier 3 analysis assessed the functional impact of VUS that remained after tier 1 and tier 2 analysis. Results: Overall, a pathogenic or likely pathogenic variant was identified in 41% of participants with a cardiomyopathy, 40% with an arrhythmia syndrome, and 15% with a familial CHD/CHD+Extra Cardiac Anomalies. A VUS outcome ranged from 13% for arrhythmias to 34% for CHD/CHD+Extra Cardiac Anomalies participants. Tier 2 research analysis identified a likely pathogenic/pathogenic variant for a further 15 participants and a VUS for an additional 15 participants. Conclusion: The Flagship successfully facilitated a model of care that harnesses clinical GS and functional genomics for the resolution of VUS in the clinical setting. This valuable data set can be used to inform clinical practice and facilitate research into the future.

ABSTRACTThe present report summarizes the United States Department of Veterans Affairs (VA) field-based meeting titled “Modulating microbiome-immune axis in the deployment-related chronic diseases of Veterans.” Our Veteran patient population experiences a high incidence of service-related chronic physical and mental health problems, such as infection, irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), various forms of hematological and non-hematological malignancies, neurologic conditions, end-stage organ failure, requiring transplantation, and posttraumatic stress disorder (PTSD). We report the views of a group of scientists who focus on the current state of scientific knowledge elucidating the mechanisms underlying the aforementioned disorders, novel therapeutic targets, and development of new approaches for clinical intervention. In conclusion, we dovetailed on four research areas of interest: 1) microbiome interaction with immune cells after hematopoietic cell and/or solid organ transplantation, graft-versus-host disease (GVHD) and graft rejection, 2) intestinal inflammation and its modification in IBD and cancer, 3) microbiome-neuron-immunity interplay in mental and physical health, and 4) microbiome-micronutrient-immune interactions during homeostasis and infectious diseases. At this VA field-based meeting, we proposed to explore a multi-disciplinary, multi-institutional, collaborative strategy to initiate a roadmap, specifically focusing on host microbiome-immune interactions among those with service-related chronic diseases to potentially identify novel and translatable therapeutic targets.

Las microsoberanías han adquirido una importancia creciente para los Estados que buscan fortalecer su control territorial. Las microsoberanías pueden tener un impacto desproporcionado con relación a su tamaño y el número de habitantes que las apoyan. En este artículo, se ofrece una definición del concepto de microsoberanías y se proporcionan criterios para identificarlas y evaluarlas cualitativamente. Se muestra que, además de ser un desafío para la soberanía de las naciones, también representan una oportunidad, sobre todo en regímenes democráticos, para fortalecer la soberanía a través de redes de poder en que se coopere con las microsoberanías, teniendo en cuenta las fortalezas de estas en autoridad moral y vínculo con la población.

IntroductionThe ubiquitin-proteasome system (UPS) is an intracellular organelle responsible for targeted protein degradation, which represents a standard therapeutic target for many different human malignancies. Bortezomib, a reversible inhibitor of chymotrypsin-like proteasome activity, was first approved by the FDA in 2003 to treat multiple myeloma and is now used to treat a number of different cancers, including relapsed mantle cell lymphoma, diffuse large B-cell lymphoma, colorectal cancer, and thyroid carcinoma. Despite the success, bortezomib and other proteasome inhibitors are subject to severe side effects, and ultimately, drug resistance. We recently reported an oncogenic role for non-ATPase members of the 19S proteasome in chronic myeloid leukemia (CML), acute myeloid leukemia (AML), and several different solid tumors. In the present study, we hypothesized that ATPase members of the 19S proteasome would also serve as biomarkers and putative therapeutic targets in AML and multiple other cancers.MethodsWe used data from The Cancer Genome Atlas (TCGA) and the Clinical Proteomic Tumor Analysis Consortium (CPTAC) available at UALCAN and/or GEPIA2 to assess the expression and prognostic value of proteasome 26S subunit, ATPases 1-6 (PSMC1-6) of the 19S proteasome in cancer. UALCAN was also used to associate PSMC1-6 mRNA expression with distinct clinicopathological features. Finally, cBioPortal was employed to assess genomic alterations of PSMC genes across different cancer types.ResultsThe mRNA and protein expression of PSMC1-6 of the 19S proteasome were elevated in several cancers compared with normal controls, which often correlated with worse overall survival. In contrast, AML patients demonstrated reduced expression of these proteasome subunits compared with normal mononuclear cells. However, AML patients with high expression of PSMC2-5 had worse outcomes.DiscussionAltogether, our data suggest that components of the 19S proteasome could serve as prognostic biomarkers and novel therapeutic targets in AML and several other human malignancies.

Early detection of firearm discharge has become increasingly critical for situational awareness in both civilian and military domains. The ability to determine the location and model of a discharged firearm is vital, as this can inform effective response plans. To this end, several gunshot audio datasets have been released that aim to facilitate gunshot detection and classification of a discharged firearm based on acoustic signatures. However, these datasets often suffer from a lack of variety in the orientations of recording devices around the source of the gunshot. Additionally, these datasets often suffer from the absence of proper time synchronization, which prevents the usage of these datasets for determining the Direction of Arrival (DoA) of the sound. In this paper, we present a multi-firearm, multi-orientation time-synchronized audio dataset collected in a semi-controlled real-world setting – providing us a degree of supervision – using several edge devices positioned in and around an outdoor firing range.

Abstract Coronavirus disease 2019 (COVID‐19) patients have increased thrombosis risk. With increasing age, there is an increase in COVID‐19 severity. Additionally, adults with a history of vasculopathy have the highest thrombotic risk in COVID‐19. The mechanisms of these clinical differences in risk remain unclear. Human umbilical vein endothelial cells (HUVECs) were infected with SARS‐CoV‐2, influenza A/Singapore/6/86 (H1N1) or mock‐infected prior to incubation with plasma from healthy children, healthy adults or vasculopathic adults. Fibrin on surface of cells was observed using scanning electron microscopy, and fibrin characteristics were quantified. This experiment was repeated in the presence of bivalirudin, defibrotide, low‐molecular‐weight‐heparin (LMWH) and unfractionated heparin (UFH). Fibrin formed on SARS‐CoV‐2 infected HUVECs was densely packed and contained more fibrin compared to mock‐infected cells. Fibrin generated from child plasma was the thicker than fibrin generated in vasculopathic adult plasma (p = 0.0165). Clot formation was inhibited by LMWH (0.5 U/ml) and UFH (0.1–0.7 U/ml). We show that in the context of the SARS‐CoV‐2 infection on an endothelial culture, plasma from vasculopathic adults produces fibrin clots with thinner fibrin, indicating that the plasma coagulation system may play a role in determining the thrombotic outcome of SARS‐CoV‐2 infection. Heparinoid anticoagulants were most effective at preventing clot formation.

Privacy remains one of the most recurrent concerns that people have about AI technologies. The meaning of the concept of “privacy” has proven to be fairly elusive. Accordingly, the concerns people have about privacy are often vague and ill-formed, which makes it correspondingly difficult to address these concerns, and to explain the ways in which AI technologies do or do not pose threats to people's interests. In this article, we draw attention to some important distinctions that are frequently overlooked, and spell out their implications for concerns about the threats that AI-related technology poses for privacy. We argue that, when people express concerns about privacy in relation to AI technologies, they are usually referring to security interests rather than interests in privacy per se. Nevertheless, we argue that focusing primarily on security interests misses the importance that interests in privacy per se have through their contribution to autonomy and the development of our identities. Improving insight about these issues can make it easier for the developers of AI technologies to provide explanations for users about what interests are and are not at stake through the use of AI systems.

BackgroundLimited research evidence exists on the development of web-based platforms for reciprocal communication, coproduction research, and dissemination of information among parents, professionals, and researchers. This paper provides learning and the outcomes of setting up a bespoke web-based platform using social media. ObjectiveThis study aims to explore the establishment of a web-based, multicontextual research communication platform for parents and stakeholders of children with congenital anomalies using social media and to identify associated research and ethical and technical challenges. MethodsThe ConnectEpeople e-forum was developed using social media platforms with a stakeholder engagement process. A multilevel approach was implemented for reciprocal engagement between parents of children with congenital anomalies, researchers, health care professionals, and other stakeholders using private and invisible and public Facebook groups, closed Twitter groups, and YouTube. Ethical approval was obtained from Ulster University. ResultsNonprofit organizations (N=128) were invited to engage with an initial response rate of 16.4% (21/128). Of the 105 parents contacted, 32 entered the private and invisible Facebook groups to participate in the coproduction research. Public Facebook page followers rose to 215, a total of 22 posts had an engagement of >10%, and 34 posts had a reach of over 100. Webinars included requested information on childhood milestones and behavior. YouTube coverage included 106 ConnectEpeople videos with 28,708 impressions. Project information was obtained from 35 countries. The highest Facebook activity occurred during the early morning hours. Achievement of these results required dedicated time management, social media expertise, creativity, and sharing knowledge to curate valuable content. ConclusionsBuilding and maintaining a multilayered online forum for coproduction and information sharing is challenging. Technical considerations include understanding the functionality and versatility of social media metrics. Social media offers valuable, easily accessible, quantitative, and qualitative data that can drive the reciprocal process of forum development. The identification and integration of the needs of the ConnectEpeople e-forum was a key driver in the dissemination of useful, meaningful, and accessible information. The necessary dedicated administration to respond to requests and posts and collate data required significant time and effort. Participant safety, the development of trust, and the maintenance of confidentiality were major ethical considerations. Discussions on social media platforms enabled parents to support each other and their children. Social media platforms are particularly useful in identifying common family needs related to early childhood development. This research approach was challenging but resulted in valuable outputs requiring further application and testing. This may be of particular importance in response to COVID-19 or future pandemics. Incorporating flexible, adaptable social media strategies into research projects is recommended to develop effective platforms for collaborative and impactful research and dissemination.

Abstract The basal zone of glaciers is characterized by physicochemical properties that are distinct from firnified ice due to strong interactions with underlying substrate and bedrock. Basal ice (BI) ecology and the roles that the microbiota play in biogeochemical cycling, weathering, and proglacial soil formation remain poorly described. We report on basal ice geochemistry, bacterial diversity (16S rRNA gene phylogeny), and inferred ecological roles at three temperate Icelandic glaciers. We sampled three physically distinct basal ice facies (stratified, dispersed, and debris bands) and found facies dependent on biological similarities and differences; basal ice character is therefore an important sampling consideration in future studies. Based on a high abundance of silicates and Fe‐containing minerals and, compared to earlier BI literature, total C was detected that could sustain the basal ice ecosystem. It was hypothesized that C‐fixing chemolithotrophic bacteria, especially Fe‐oxidisers and hydrogenotrophs, mutualistically support associated heterotrophic communities. Basal ice‐derived rRNA gene sequences corresponding to genera known to harbor hydrogenotrophic methanogens suggest that silicate comminution‐derived hydrogen can also be utilized for methanogenesis. PICRUSt‐predicted metabolism suggests that methane metabolism and C‐fixation pathways could be highly relevant in BI, indicating the importance of these metabolic routes. The nutrients and microbial communities release from melting basal ice may play an important role in promoting pioneering communities establishment and soil development in deglaciating forelands.

Purpose: Stereotactic body radiation therapy (SBRT) use has increased among patients without pathologic confirmation (PC) of lung cancer. Empirical SBRT without PC raises concerns about variation in workup and patient selection, but national trends have not been well described. In this study, we assessed patterns of empirical SBRT use, workup, and causes of death among a large national non-small cell lung cancer (NSCLC) cohort. Methods and Materials: We identified 2221 patients treated with SBRT for cT1-T2aN0M0 NSCLC in the Veterans Affairs health care system from 2008 to 2015. We reviewed their pretreatment workup and assessed associations between absence of PC and clinical and demographic factors. We compared causes of death between PC and non-PC groups and used Cox proportional hazards modeling to compare overall survival and lung cancer specific survival (LCSS) between these groups. Results: Treatment without PC varied from 0% to 61% among Veterans Affairs medical centers, with at least 5 cases of stage I NSCLC. Overall, 14.9% of patients were treated without PC and 8.8% did not have a biopsy attempt. Ten percent of facilities were responsible for almost two-thirds (62%) of cases of treatment without PC. Of non-PC patients, 95.5% had positron emission tomography scans, 40.6% had biopsy procedures attempted, and 12.7% underwent endobronchial ultrasound. Non-PC patients were more likely to have cT1 tumors and live outside the histoplasmosis belt. Age, sex, smoking status, and Charlson comorbidity index were similar between groups. Lung cancer was the most common cause of death in both groups. Overall survival was similar between groups, whereas non-PC patients had better LCSS (hazard ratio = 0.77, P = .031). Conclusions: Empirical SBRT use varied widely among institutions and appropriate radiographic workup was consistently used in this national cohort. Future studies should investigate determinants of variation and reasons for higher LCSS among non-PC patients.

Abstract Background Coral reefs face unprecedented declines in diversity and cover, a development largely attributed to climate change-induced bleaching and subsequent disease outbreaks. Coral-associated microbiomes may strongly influence the fitness of their hosts and alter heat tolerance and disease susceptibility of coral colonies. Here, we describe a new coral disease found in Micronesia and present a detailed assessment of infection-driven changes in the coral microbiome. Results Combining field monitoring and histological, microscopic and next-generation barcoding assessments, we demonstrate that the outbreak of the disease, named ‘grey-patch disease’, is associated with the establishment of cyanobacterial biofilm overgrowing coral tissue. The disease is characterised by slow progression rates, with coral tissue sometimes growing back over the GPD biofilm. Network analysis of the corals’ microbiome highlighted the clustering of specific microbes which appeared to benefit from the onset of disease, resulting in the formation of ‘infection clusters’ in the microbiomes of apparently healthy corals. Conclusions Our results appear to be in contrast to the recently proposed Anna-Karenina principle, which states that disturbances (such as disease) trigger chaotic dynamics in microbial communities and increase β-diversity. Here, we show significantly higher community similarity (compositional homogeneity) in the pathobiome of diseased corals, compared to the microbiome associated with apparently healthy tissue. A possible explanation for this pattern is strong competition between the pathogenic community and those associated with the ‘healthy’ coral holobiont, homogenising the composition of the pathobiome. Further, one of our key findings is that multiple agents appear to be involved in degrading the corals’ defences causing the onset of this disease. This supports recent findings indicating a need for a shift from the one-pathogen-one-disease paradigm to exploring the importance of multiple pathogenic players in any given disease.

Connected and automated vehicle (CAV) is a transformative technology that has great potential to change our daily life. Therefore, CAV related research has been advanced significantly in recent years. This paper does a comprehensive review on five selected subjects that lie in the heart of CAV research: (i) inter-CAV communications; (ii) security of CAVs; (iii) intersection control for CAVs; (iv) collision-free navigation of CAVs; and (v) pedestrian detection and protection. It is believed that these topics are essential to ensure the success of CAVs and need to be better understood. For inter-CAV communications, this paper focuses on both Dedicated Short Range Communications (DSRC) and the future 5G cellular technologies; for security of CAVs, this paper discusses both passive and active attacks and the existing solutions; for intersection control, this paper summarizes the pros and cons of both centralized and decentralized approaches; for collision avoidance, this paper concentrates on four subareas: maneuverability, vehicle networking, control confliction, and motorcycles; for pedestrian detection, this paper covers sensor, radar, and computer vision based approaches. Under each topic, this paper not only shows the state-of-the-art, but also unveils potential future research directions. By establishing connections among these subjects, this paper shows how they interact with each other and how they can be integrated into a seamless user experience. It is believed that the literature covered and conclusions drawn in this paper are very helpful to CAV researchers, application engineers, and policy makers. Keywords: Connected and automated vehicles, Autonomous vehicles, Intelligent transportation systems, Driver-less cars

The provision of suitable incubation environments is vital for successful implementation of bio self-healing concrete (bio-concrete). We investigated the effect of soil incubation to examine if the self-healing process can be activated in comparison with the conventional incubation environment (water). The data was collected from laboratory-scale experiments conducted on mortar specimens. The mortar was impregnated with Bacillus subtilis and this bacteria was encapsulated in calcium alginate for protection from the production process. The mortar specimens were mechanically cracked and then incubated within fine-grained fully saturated natural soil for about 4 weeks. The cracks were inspected before and after incubation by light microscopy to evaluate the healing ratio. The mineral precipitations on crack surfaces were examined by Scanning Electron Microscope (SEM) and Energy Dispersive X-Ray Spectrometry (EDX). The data reflects the efficiency of bio-concrete for certain structures such as tunnels and deep foundation, where concrete elements are exposed to ground conditions. Keywords: Self-healing concrete, Bacteria, Soil incubation, Scanning Electron Microscope (SEM), Energy Dispersive X-Ray Spectrometry (EDX)

British curator David Elliott led the Museum of Modern Art in Oxford (MoMA) between 1976 and 1996. During this time, he developed a distinctively diverse and international programme in which twentieth-century art from Asia played a significant role, including landmark multi-exhibition projects devoted to India (1982), Japan (1985), and China (1993). Subsequently, he has been director of the Moderna Museet in Stockholm, the Mori Art Gallery in Tokyo, and the Istanbul Modern, in addition to directing biennial exhibitions in Moscow, Kiev, and Sydney. He is currently vice-director and senior curator at the Redtory Museum of Contemporary Art (RMCA) in Guangzhou. His book Art and Trousers: Tradition and Modernity in Contemporary Asian Art includes an essay reflecting on exhibitions of Asian art staged at MoMA during his time as director, and will be published by ArtAsiaPacific in spring 2020. He discusses those projects, in particular his influential series of exhibitions clustered under the title India: Myth and Reality, in this interview with curator and art historian Hilary Floe. Her doctoral dissertation considering the early history of MoMA (1965–1982) was completed at the University of Oxford in 2016.

Understanding the effectiveness of peer mentor training in online learning environments prepares students for their roles as online peer mentors. In the Learning Assistant peer mentor program, Learning Assistants (LAs) play a crucial role in supporting student learning and engagement in STEM courses. Due to the shift to online learning during the COVID-19 pandemic, many LAs began working in online synchronous and asynchronous courses. We gathered information on challenging interactions encountered by LAs, and the frequencies of these interactions were analyzed and compared between the two learning environments. The results revealed that while no new challenging interactions emerged in the online environment, there were nuances in how existing interactions manifested online. In this article, we present new challenging interaction scenarios designed for online learning environments. These scenarios aim to enhance the training in the LA pedagogy course. Furthermore, the study highlights the significance of behavioral engagement barriers, such as unprepared and disinterested students, which had higher frequencies in both in-person and online environments. These findings help create a foundation for online LA training by incorporating new scenarios and focusing on behavioral engagement barriers to help the LA pedagogy course better equip LAs to navigate challenging interactions and support student learning.

This study focused on the development and usability evaluation of EnCare diagnostics (ECD) and the brain fit plan (BFP) in healthy older adults, cognitively impaired and physically impaired individuals. ECD is proposed as a novel solution to cognitive assessment based on colour selection. BFP is a novel solution to personalised cognitive stimulation. The study consisted of two trials designed to evaluate the usability of the apps. Trial 1 involved 11 healthy older adults and four older adults with physical impairments who undertook ECD and mini-mental state examination (MMSE) once per month for 4 months with only those with physical impairments also completing the BFP daily. Trial 2 involved eight older adults diagnosed with early stage dementia who completed MMSE and ECD once per month for 6 months. In Trial 1, 10 out of 11 participants enjoyed the trial and managed the usability of the app easily. A 75% drop out was observed in response to the BFP with issues of dexterity and lack of understanding on how to use the technology being the main reasons for lack of compliance. Four out of eight participants completed Trial 2 with most of the participants having no usability issues. This usability study demonstrated that ECD is highly acceptable in both healthy older adults and those with early stage dementia when given the shorter versions to accommodate their diagnosis. The BFP was not suited to this population of participants.

This paper proposes that educative and ethical music making and teaching, which is based on a praxial philosophy of music education (Elliott and Silverman, 2014), can be carried out in a variety of ways that create places and spaces, in schools and community settings, for a variety of human values or “goods” that include, but go beyond, making and listening to classical instrumental music, or any other kind of music, for “the music itself.” One premise of this philosophical discussion is that music does not have one value; music has numerous values, depending on the ways in which it is conceived, used, and taught by people who engage in specific musical styles. For example, when music education is ethically guided—when we teach people not only in and about music, but also through music—we achieve what Aristotle and many other philosophers consider the highest human value—eudaimonia—which is a multidimensional term we explain the body of this paper. Following an examination of three community music settings that exemplify educative and ethical musical interactions, the paper provides a brief explanation of the nature of personhood that draws from embodied, enactive, empathetic, and ecological concepts put forth by several contemporary cognitive scientists and philosophers of mind nature. This sections leads to an examination to main constituents of eudaimonia: happiness and well- being as conceived by various scholars during the last 2500 years. The discussion ends by integrated the above themes with a discussion of a praxial philosophy of music education and its implications for school and community music education.

BACKGROUND: The high mortality rates that follow the onset of acute kidney injury (AKI) are well recognised. However, the mode of death in patients with AKI remains relatively under-studied, particularly in general hospitalised populations who represent the majority of those affected. We sought to describe the primary cause of death in a large group of prospectively identified patients with AKI. METHODS: All patients sustaining AKI at our centre between 1(st) October 2010 and 31(st) October 2011 were identified by real-time, hospital-wide, electronic AKI reporting based on the Acute Kidney Injury Network (AKIN) diagnostic criteria. Using this system we are able to generate a prospective database of all AKI cases that includes demographic, outcome and hospital coding data. For those patients that died during hospital admission, cause of death was derived from the Medical Certificate of Cause of Death. RESULTS: During the study period there were 3,930 patients who sustained AKI; 62.0% had AKI stage 1, 20.6% had stage 2 and 17.4% stage 3. In-hospital mortality rate was 21.9% (859 patients). Cause of death could be identified in 93.4% of cases. There were three main disease categories accounting for three quarters of all mortality; sepsis (41.1%), cardiovascular disease (19.2%) and malignancy (12.9%). The major diagnosis leading to sepsis was pneumonia, whilst cardiovascular death was largely a result of heart failure and ischaemic heart disease. AKI was the primary cause of death in only 3% of cases. CONCLUSIONS: Mortality associated with AKI remains high, although cause of death is usually concurrent illness. Specific strategies to improve outcomes may therefore need to target not just the management of AKI but also the most relevant co-existing conditions.

Understanding the effectiveness of peer mentor training in online learning environments prepares students for their roles as online peer mentors. In the Learning Assistant peer mentor program, Learning Assistants (LAs) play a crucial role in supporting student learning and engagement in STEM courses. Due to the shift to online learning during the COVID-19 pandemic, many LAs began working in online synchronous and asynchronous courses. We gathered information on challenging interactions encountered by LAs, and the frequencies of these interactions were analyzed and compared between the two learning environments. The results revealed that while no new challenging interactions emerged in the online environment, there were nuances in how existing interactions manifested online. In this article, we present new challenging interaction scenarios designed for online learning environments. These scenarios aim to enhance the training in the LA pedagogy course. Furthermore, the study highlights the significance of behavioral engagement barriers, such as unprepared and disinterested students, which had higher frequencies in both in-person and online environments. These findings help create a foundation for online LA training by incorporating new scenarios and focusing on behavioral engagement barriers to help the LA pedagogy course better equip LAs to navigate challenging interactions and support student learning. [ABSTRACT FROM AUTHOR]