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1. Aberrant PRDM2 methylation as an early event in serrated lesions destined to evolve into microsatellite‐instable colorectal cancers

Author

David EFWM vanToledo, Arne GC Bleijenberg, Andrea Venema, Mireille J deWit, Susanne vanEeden, Gerrit A Meijer, Beatrice Carvalho, Evelien Dekker, Peter Henneman, Joep EG IJspeert, and Carel JM vanNoesel

Subjects
colorectal cancer, sessile serrated lesions, serrated neoplasia pathway, methylation, Pathology, RB1-214
Abstract

Abstract Up to 30% of colorectal cancers (CRCs) develop from sessile serrated lesions (SSLs). Within the serrated neoplasia pathway, at least two principally distinct oncogenetic routes exist generating microsatellite‐stable and microsatellite‐instable CRCs, respectively. Aberrant DNA methylation (DNAm) is found early in the serrated pathway and might play a role in both oncogenetic routes. We studied a cohort of 23 SSLs with a small focus (

Published
2024
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