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Records of pressure variations on seismographs were historically considered unwanted noise; however, increased deployments of collocated seismic and acoustic instrumentation have driven recent efforts to use this effect induced by both wind and anthropogenic explosions to invert for near-surface Earth structure. These studies have been limited to shallow structure because the pressure signals have relatively short wavelengths (0.8) correlations between pressure and vertical component ground motion at 83% of the stations, but only 30% of stations show this on the radial component, likely due to complex tilt effects. We use average elastic properties in the upper 5.2 km from the CRUST1.0 model to estimate vertical seismic/acoustic coupling coefficients (SV/A) across the GSN network and compare these to recorded observations. We exclude many island stations from these comparisons because the 1° resolution of the CRUST1.0 model places a water layer below these stations. Our simple modeling can predict observed SV/A within a factor of 2 for 94% of the 51 non-island GSN stations with high correlations between pressure and ground motion. These results indicate that analysis of acoustic-to-seismic coupling from the eruption could be used to place additional constraints on crustal structure models at stations with collocated seismic and pressure sensors. Ultimately, this could improve tomographic imaging models, which rely on methods that are sensitive to local structure.

This study examines how different forms of media use predict attitudes toward the development of facial recognition technology (FRT) and applications of it by law enforcement to identify criminal suspects, identify potential terrorists, and monitor public protests. The theoretical framework builds on theories of cultivation and genre-specific viewing to develop hypotheses and research questions. The analyses draw on original data from two nationally representative surveys of the U.S. public conducted in 2020, amid a series of controversies and protests about policing and racial justice. The results demonstrate that overall television viewing and crime media viewing predicted support for multiple uses of FRT, while Fox News viewing predicted support for using FRT to monitor protests. The findings advance our understanding of public opinion toward the technology and its implications for policing, protests, and social justice.

This study examines how members of the public frame artificial intelligence (AI) along with how news use predicts “frames in mind” for AI. The study also tests whether news use, science fiction viewing, and discussing technology influence attitudes toward AI independently and in conjunction with one another. The analyses use data from a nationally representative online panel survey. Respondents invoked social progress and Pandora’s box frames for AI, and technology news use predicted mentioning each frame. Use of technology news also predicted change in support for AI, while science fiction viewing and discussing technology were conditionally related to such change.

Background and Aims Thromboprophylaxis use in paediatric inflammatory bowel disease [IBD] is inconsistent. Current guidelines only support treating children with acute severe colitis with risk factors. We convened an international RAND panel to explore thromboprophylaxis in paediatric IBD inpatients in the context of new evidence. Methods We convened a geographically diverse 14-person panel of paediatric gastroenterologists alongside supporting experts. An online survey was sent before an online meeting. Panellists were asked to rate the appropriateness of thromboprophylaxis in hospitalised paediatric IBD patients via 27 scenarios of varying ages, gender, and phenotype, with and without thrombotic risk factors. Anonymised results were presented at the meeting. A second modified survey was distributed to all panellists present at the meeting. Results from the second survey constitute the RAND panel results. The validated RAND disagreement index defined disagreement when ≥ 1. Results The combined outcome of thromboprophylaxis being considered appropriate until discharge and inappropriate to withhold was seen in 20 of 27 scenarios, including: all patients with new-onset acute severe colitis; all flares of known ulcerative colitis, irrespective of risk factors except in pre-pubescent patients with limited disease and no risk factors; and all Crohn’s patients with risk factors. Disagreement was seen in five scenarios regarding Crohn’s without risk factors, where outcomes were already uncertain. Conclusions RAND panels are an established method to assess expert opinion in areas of limited evidence. This work therefore constitutes neither a guideline nor a consensus; however, the findings suggest a need to re-evaluate the role of thromboprophylaxis in future guidelines.

The 15 January 2022 climactic eruption of Hunga volcano, Tonga, produced an explosion in the atmosphere of a size that has not been documented in the modern geophysical record. The event generated a broad range of atmospheric waves observed globally by various ground-based and spaceborne instrumentation networks. Most prominent was the surface-guided Lamb wave (≲0.01 hertz), which we observed propagating for four (plus three antipodal) passages around Earth over 6 days. As measured by the Lamb wave amplitudes, the climactic Hunga explosion was comparable in size to that of the 1883 Krakatau eruption. The Hunga eruption produced remarkable globally detected infrasound (0.01 to 20 hertz), long-range (~10,000 kilometers) audible sound, and ionospheric perturbations. Seismometers worldwide recorded pure seismic and air-to-ground coupled waves. Air-to-sea coupling likely contributed to fast-arriving tsunamis. Here, we highlight exceptional observations of the atmospheric waves.

Background Current data on dual biologic therapy in children are limited. This multicenter study aimed to evaluate the effectiveness and safety of dual therapy in pediatric patients with inflammatory bowel disease (IBD). Methods A retrospective study from 14 centers affiliated with the Pediatric IBD Interest and Porto Groups of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition. Included were children with IBD who underwent combinations of biologic agents or biologic and small molecule therapy for at least 3 months. Demographic, clinical, laboratory, endoscopic, and imaging data were collected. Adverse events were recorded. Results Sixty-two children (35 Crohn’s disease, 27 ulcerative colitis; median age 15.5 [interquartile range, 13.1-16.8] years) were included. They had all failed previous biologic therapies, and 47 (76%) failed at least 2 biologic agents. The dual therapy included an anti-tumor necrosis factor agent and vedolizumab in 30 children (48%), anti-tumor necrosis factor and ustekinumab in 21 (34%) children, vedolizumab and ustekinumab in 8 (13%) children, and tofacitinib with a biologic in 3 (5%) children. Clinical remission was observed in 21 (35%), 30 (50%), and 38 (63%) children at 3, 6, and 12 months, respectively. Normalization of C-reactive protein and decrease in fecal calprotectin to Conclusions Dual biologic therapy may be effective in children with refractory IBD. The potential efficacy should be weighed against the risk of serious adverse events.

Racial reckoning in response to racial injustice has compelled individuals, organizations, and institutions to acknowledge and adopt policies that actively challenge racial injustice. A central tenet of this era of reckoning is that it is no longer acceptable to ignore racist behaviors and expressions. To the extent that active opposition to racial prejudice is an effective strategy for individuals to pursue, we examine individual inclinations to act on matters of racial prejudice. We argue that in spite of best intentions, the motivation to act against racism, what we call “antiracism action orientation,” can be disrupted by system-justifying beliefs that raise questions about deservingness, legitimize the status quo, and therefore defend inaction. Survey data from the 2020 Congressional Election Study show that antiracism action orientation is strongest among African Americans, and those with more positive affect toward racial-ethnic minorities, and supporters of change. Among Whites, racial resentment dominates the motivations for antiracism to the point that typical political allies like Democrats, liberals, and those who acknowledge White privilege reduce their antiracism action orientation to lower levels than Republicans, conservatives, and deniers of White privilege. We conclude that most Americans, but especially Whites, have a high bar for change, making racism an ongoing American dilemma because of both racial attitudes and the costs of change.

The U.S. Geological Survey (USGS) maintains an archive of 189,180 digitized scans of analog seismic records from the World-Wide Standardized Seismograph Network (WWSSN). Although these scans have been made public, the archive is too large to manually review, and few researchers have utilized large numbers of these records. To facilitate further research using this historical dataset, we develop a simple convolutional neural network (CNN) that rapidly (∼4.75 s/film chip) classifies scanned film chip images (called “chips,” because they are individually cut segments of 70 mm film) into four categories of “interestingness” to earthquake seismologists based on the presence of earthquakes and other seismic signals in the record: “no interest,” “little interest,” “interest,” and “high interest.” The CNN, dubbed “Seismic Analog Record Network” (SARNet), can identify four types of seismic traces (“no events,” “minor events,” “major events,” and “errors”) in 200 × 200 pixel subcrops with an accuracy of 92% using a confidence threshold of 85%. SARNet then converts 100 random subcrops from each film chip into the overall classification of interestingness. In this task, SARNet performed as well as expert human classifiers in determining the film chip’s overall interest grade. Applying SARNet to 34,000 film chips in the WWSSN archive found that 21% of the images were of “high interest” and had an “indeterminate” rate of only 4%. Thus, the need for the manual review of images was reduced by 79%. Sorting of film chips derived from SARNet will expedite further exploration of the archive of digitized analog seismic records stored at the USGS.

SUMMARY Acoustic energy originating from explosions, sonic booms, bolides and thunderclaps have been recorded on seismometers since the 1950s. Direct pressure loading from the passing acoustic wave has been modelled and consistently observed to produce ground deformations of the near surface that have retrograde elliptical particle motions. In the past decade, increased deployments of colocated seismometers and infrasound sensors have driven efforts to use the transfer function between direct acoustic-to-seismic coupling to infer near-surface material properties including seismic velocity structure and elastic moduli. In this study, we use a small aperture (≈600 m) array of broadband seismometers installed in different manners and depths in both granite and sedimentary overburden to understand the fundamental nature and repeatability of seismic excitation from 1 to 15 Hz using horizontally propagating acoustic waves generated by 97 local (2–10 km) explosions. In agreement with modelling, we find that the ground motions induced by acoustic-to-seismic coupling attenuate rapidly with depth. We confirm the modelled relation between acoustic and ground motion amplitudes, but show that within one acoustic wavelength, the uncertainty in the transfer coefficient between seismic and acoustic energy at a given seismic station increases linearly with separation distance between the seismic and acoustic sensor. We attribute this observation to the rapid decorrelation of the infrasonic wavefield across small spatial scales and recommend colocating seismic and infrasound sensors for use in studies seeking to invert for near-surface material properties. Additionally, contrary to acoustic-to-seismic coupling theory and prior observations, we find that seismometers emplaced in granite do not record retrograde elliptical particle motions in response to direct pressure loading. We rule out seismometer tilt effects as a likely source of this observations and suggest that existing models of acoustic-to-seismic excitation may be too simplistic for seismometers placed in high rigidity materials.

Background and Aims:The incidence of paediatric-onset inflammatory bowel disease (PIBD) continues to rise globally. We aimed to determine whether mode of delivery, gestational age at birth, or type of infant feeding contribute to the development of PIBD in a nationwide cohort of Scottish children.Methods:All children born in Scotland between 1981-2017 were identified using linked health administrative data to determine mode of delivery, gestational age at birth, and type of infant feeding. PIBD cases were defined as onset of Crohn’s disease (CD), ulcerative colitis (UC) or IBD-unclassified (IBDU) before age 16 years. Validation was performed within an entire Scottish health board (16% of total population) via individual case-note verification. Hazard ratios (HR) were calculated for each exposure using Cox proportional hazards models.Results:A study population of 2,013,851 children was identified including 1,721 PIBD cases. Validation of 261 PIBD patients coded as CD and/or UC identified 242 (93%) as true positive. Children delivered vaginally did not have an altered risk of developing PIBD compared to those delivered by caesarean section; adjusted HR 0.95 [95% CI 0.84-1.08] (p=0.46). Compared to children born at term (≥37 weeks), children born prematurely did not have an altered risk of developing PIBD; 24-31 weeks gestation HR 0.99 [95% CI 0.57-1.71] (p=0.97); 32-36 weeks gestation HR 0.96 (95% CI 0.76-1.20] (p=0.71). Compared to children exclusively breast fed at age 6 weeks, children exclusively formula fed did not have an altered risk of developing PIBD; adjusted HR 0.97 [95% CI 0.81-1.15] (p=0.69).Conclusions:This population-based study demonstrates no association between mode of delivery, gestational age, or exclusive formula feeding at 6 weeks and the development of PIBD.

Virtually all states have developed best management practices (BMPs) to mitigate potential adverse effects associated with timber harvesting. This study examined how BMP implementation on Minnesota’s family forest lands varied according to whether the land had a forest management plan, the timber sale was administered by a forester, or a written timber harvesting contract was used. Analysis of field monitoring data from 174 commercial timber harvesting sites on family forest lands found that BMP implementation is only modestly influenced by a forest management plan, supervising forester, or timber harvesting contract. Supervision of a forester had the greatest influence, with six guidelines implemented differently. In contrast, differences were found for just two BMPs with a forest management plan and only one with a written timber harvesting contract. When timber sales were administered by a forester, forest management guidelines generally related to management of the land-water interface were implemented to a higher standard, with significant increases observed for avoidance of infrastructure in filter strips, use of water diversion and erosion control structures, avoiding unnecessary wetland and waterbody crossings, and slash management. Higher timber utilization efficiency (within leave tree guidelines) was also found when a professional forester supervised the timber sale. Study Implications: We examine how BMP implementation on family forest lands varies with three types of supervisory and planning assistance: a forest management plan for the property, sale administration by a professional forester, and a written timber harvesting contract. Field monitoring data from 174 commercial timber harvests on family forest lands indicate that BMP implementation is only modestly influenced by any single form of assistance. Supervision by a forester had the greatest influence, increasing use of four guidelines related to management of the land-water interface. Results may help to inform best practices for landowner assistance and planning.

Although polling is not irredeemably broken, changes in technology and society create challenges that, if not addressed well, can threaten the quality of election polls and other important surveys on topics such as the economy. This essay describes some of these challenges and recommends remediations to protect the integrity of all kinds of survey research, including election polls. These 12 recommendations specify ways that survey researchers, and those who use polls and other public-oriented surveys, can increase the accuracy and trustworthiness of their data and analyses. Many of these recommendations align practice with the scientific norms of transparency, clarity, and self-correction. The transparency recommendations focus on improving disclosure of factors that affect the nature and quality of survey data. The clarity recommendations call for more precise use of terms such as “representative sample” and clear description of survey attributes that can affect accuracy. The recommendation about correcting the record urges the creation of a publicly available, professionally curated archive of identified technical problems and their remedies. The paper also calls for development of better benchmarks and for additional research on the effects of panel conditioning. Finally, the authors suggest ways to help people who want to use or learn from survey research understand the strengths and limitations of surveys and distinguish legitimate and problematic uses of these methods.

Genomic medicine enables the identification of patients with rare or ultra-rare monogenic forms of inflammatory bowel disease (IBD) and supports clinical decision making. Patients with monogenic IBD frequently experience extremely early onset of treatment-refractory disease, with complex extraintestinal disease typical of immunodeficiency. Since more than 100 monogenic disorders can present with IBD, new genetic disorders and variants are being discovered every year, and as phenotypic expression of the gene defects is variable, adaptive genomic technologies are required. Monogenic IBD has become a key area to establish the concept of precision medicine. Clear guidance and standardised, affordable applications of genomic technologies are needed to implement exome or genome sequencing in clinical practice. This joint British Society of Gastroenterology and British Society of Paediatric Gastroenterology, Hepatology and Nutrition guideline aims to ensure that testing resources are appropriately applied to maximise the benefit to patients on a national scale, minimise health-care disparities in accessing genomic technologies, and optimise resource use. We set out the structural requirements for genomic medicine as part of a multidisciplinary team approach. Initiation of genomic diagnostics should be guided by diagnostic criteria for the individual patient, in particular the age of IBD onset and the patient's history, and potential implications for future therapies. We outline the diagnostic care pathway for paediatric and adult patients. This guideline considers how to handle clinically actionable findings in research studies and the impact of consumer-based genomics for monogenic IBD. This document was developed by multiple stakeholders, including UK paediatric and adult gastroenterology physicians, immunologists, transplant specialists, clinical geneticists, scientists, and research leads of UK genetic programmes, in partnership with patient representatives of several IBD and rare disease charities.

Here you can find the input and summary output datasets and the analysis protocol and R code associated with the publciation. The independent variables dataset analysed here refer to specific indicators of the WABI methodology (https://www.sciencedirect.com/science/article/pii/S0956053X14004905) that generates solid waste management and resource recovery profiles for cities. It was applied here for 40 cities around the world. Input file: Metadata info used by R codes Full data set for the WABI, used by the R codes Data required for plotting the map in Figure 1 Summary output file: Metadata info used by R codes Summary of results for two modelling approaches (machine learning: Conditional random-forest and non-linear regression), Funding - C.A.V.'s research at the University of Leeds (UoL) was supported by GIZ grant 'Solid waste flow diagram tool and ISWM benchmark indicator monitoring for cities'. The relevant WABIs web-portal was funded by EPSRC impact acceleration fund (UoL internal allocation, via the 'Cities' cross-university theme) and Wasteaware Ltd. in-kind contribution. Acknowledgements - We are grateful to UN-Habitat for funding the work on the initial version of the indicators, including 20 city profiles, and GIZ through their 'Operator Models' project which funded an intermediate version of the indicators and a further 5 city profiles. We acknowledge all the profilers of the individual cities – many are named in Table S2, and others in reference (Scheinberg et al. 2010). We thank past MSc students under the authors' supervision for offering preliminary partial data clearing and commentary: Henry Hickman (MSc dissertation at University of Leeds, supervised by C.A.V and D.C.W.) and Margaux Fargier (Final year MEng dissertation at Imperial College London, supervised by S.M.G, D.C.W and C.A.V.). We are grateful to Dr Josh Cottom and Mr Ed Cook at the University of Leeds for input on the GDP version selection. We acknowledge the support of Dr Ljiljana Rodic for contributing in data quality control.