Search

This chapter combines facts, nuances, and implications of the Turnover Tsunami and Great Resignation phenomena. The author provides important insights that connect changes at social and generational levels—notably regarding stress and burnout, engagement and commitment, and socio-technical work trends such as virtual work and the metaverse—to current and future employment challenges. The chapter is designed to open lines of sight into the most complex and dynamic times ever seen in the employment realm. The author infuses personal strategy (e.g., know your people), commentary (e.g., collective collusion), and applied theory (e.g., cognitive dissonance) to open pathways of thought, understanding, and exploration into mid-post-pandemic employment issues.

For owners of everything from hotels to nuclear licensed sites, mitigating the potential risks of blast is of paramount importance, not only to minimise the risk to human life and in doing so discharge their legal obligations to reduce risks to as low as reasonably practicable, but also to ensure resilience in their enterprises. Identifying what design changes or mitigation measures need to be introduced in a given building is a complex task, and depends on the widely varying characteristics of the blast threat – whether caused by terrorist action or by accidents arising from process failures. This mitigation can be very costly; therefore, an accurate assessment of the potential damage can help ensure measures are taken appropriate to the level of risk. Frazer-Nash has recently been using high-end computer modelling techniques that allow the potential effects of a blast in a range of sensitive locations to be analysed, for the purposes of assuring hotel designers that their buildings will provide a suitable level of resilience to terrorist attack. This utilises techniques previously considered the preserve of the defence sector over the past two decades and more, using dynamic finite-element analysis to look at blast effects on a wide range of structures.

This paper will describe the development, prototype testing, full well system test and the first field trial of an evolutionary slender well construction system. The system is a method of constructing oil and gas wells from close-clearance flush-jointed cemented liners from top to bottom to form the entire well. Significant technical hurdles were overcome in the development of a system that is safe and practical to deploy whilst at the same time allowing drilling and completions engineers to plan the wells using accepted oil and gas well engineering methods. The paper will describe the technical hurdles to overcome to enable this method of well construction to become accepted. This evolutionary method of constructing oil and gas wells has the potential to compete favorably with conventional techniques and other new technology methods already being deployed and could be used in a wide variety of well types. In its full well construction format of four or more close-clearance liners, the cost of constructing the well can be reduced significantly, perhaps by more than 50%, whilst at the same time enhancing safety and reducing environmental impact. In its partial format of one to three close-clearance liners during a sidetrack or well extension, the available flow area across the zone of interest can be increased by 100% as a result of an increased tubular size deployed at total depth compared with convention. Figure 1 shows a comparison of the system to conventional techniques for full wells and Figure 2 shows the flow area increase of the system in its partial format.

Four of five groups of Holestine by Angus calves (5 calves/group) were immunized with different formulations of a recombinant BPV-1 DNA vaccine using a BPV-1 major capsid:B-galactosidase fusion protein as the immunogen. Group 5 was not vaccinated. Vaccinated calves received the vaccine on days 0 and 21 of the trial, and calves from all five groups were challenged intradermally with 10(10) BPV-1 particles at each of two different sites on day 56. All calves were bled on days 3, 24, 55, 77, and 104 of the trial, and the sera were tested for reactivity with intact and disrupted BPV-1 particles by ELISA. At the time of challenge with BPV-1 virions (day 56), 19 of 20 vaccinated calves were seropositive for disrupted BPV-1 particles; sera from 3 of 20 calves reacted with intact BPV-1 virions. By day 77, 11 of 19 vaccinated calves had developed antibody titers to intact BPV-1 virions; only 1 calf in group 5 developed antibodies (transiently) against BPV-1 capsid epitopes. After challenge, 24 of 25 calves from the five groups developed intradermal fibromas, the biological end point of this study. Fibromas appeared to increase in size in group 5 (unvaccinated, inoculated controls), whereas most tumors from the four vaccinated groups (1-4) stabilized or decreased in size. Although the calves developed fibromas, 90% of calves (in groups 1-4) developed antibodies against disrupted BPV-1 capsid proteins whereas 58% developed antibodies that reacted with intact virions. The immunologic response of vaccinated calves to intact and disrupted BPV-1 particles appeared to be determined in large part by the various formulations of the vaccine, particularly the adjuvant.