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5. Assessment of DNA damage with an adapted independent reaction time approach implemented in Geant4-DNA for the simulation of diffusion-controlled reactions between radio-induced reactive species and a chromatin fiber.

Author

Tran, Hoang Ngoc, Ramos-Méndez, José, Shin, Wook-Geun, Perrot, Yann, Faddegon, Bruce, Okada, Shogo, Karamitros, Mathieu, Davídková, Marie, Štěpán, Václav, Incerti, Sébastien, and Villagrasa, Carmen

Subjects
DNA damage, Geant4-DNA, IRT, diffusion-controlled reaction, Nuclear Medicine & Medical Imaging, Other Physical Sciences, Biomedical Engineering, Oncology and Carcinogenesis
Abstract

PurposeSimulation of indirect damage originating from the attack of free radical species produced by ionizing radiation on biological molecules based on the independent pair approximation is investigated in this work. In addition, a new approach, relying on the independent pair approximation that is at the origin of the independent reaction time (IRT) method, is proposed in the chemical stage of Geant4-DNA.MethodsThis new approach has been designed to respect the current Geant4-DNA chemistry framework while proposing a variant IRT method. Based on the synchronous algorithm, this implementation allows us to access the information concerning the position of radicals and may make it more convenient for biological damage simulations. Estimates of the evolution of free species as well as biological hits in a segment of DNA chromatin fiber in Geant4-DNA were compared for the dynamic time step approach of the step-by-step (SBS) method, currently used in Geant4-DNA, and this newly implemented IRT.ResultsResults show a gain in computation time of a factor of 30 for high LET particle tracks with a better than 10% agreement on the number of DNA hits between the value obtained with the IRT method as implemented in this work and the SBS method currently available in Geant4-DNA.ConclusionOffering in Geant4-DNA more efficient methods for the chemical step based on the IRT method is a task in progress. For the calculation of biological damage, information on the position of chemical species is a crucial point. This can be achieved using the method presented in this paper.

Published
2021

6. Mapping the Future of Particle Radiobiology in Europe: The INSPIRE Project

Author

Henthorn, Nicholas T., Sokol, Olga, Durante, Marco, De Marzi, Ludovic, Pouzoulet, Frederic, Miszczyk, Justyna, Olko, Pawel, Brandenburg, Sytze, Goethem, Marc Jan van, Barazzuol, Lara, Tambas, Makbule, Langendijk, Johannes A., Davídková, Marie, Vondráĉek, Vladimír, Bodenstein, Elisabeth, Pawelke, Joerg, Lomax, Antony J., Weber, Damien C., Dasu, Alexandru, Stenerlöw, Bo, Poulsen, Per R., Sørensen, Brita S., Grau, Cai, Sitarz, Mateusz K., Heuskin, Anne-Catherine, Lucas, Stephane, Warmenhoven, John W., Merchant, Michael J., Mackay, Ran I., Kirkby, Karen J., Henthorn, Nicholas T., Sokol, Olga, Durante, Marco, De Marzi, Ludovic, Pouzoulet, Frederic, Miszczyk, Justyna, Olko, Pawel, Brandenburg, Sytze, Goethem, Marc Jan van, Barazzuol, Lara, Tambas, Makbule, Langendijk, Johannes A., Davídková, Marie, Vondráĉek, Vladimír, Bodenstein, Elisabeth, Pawelke, Joerg, Lomax, Antony J., Weber, Damien C., Dasu, Alexandru, Stenerlöw, Bo, Poulsen, Per R., Sørensen, Brita S., Grau, Cai, Sitarz, Mateusz K., Heuskin, Anne-Catherine, Lucas, Stephane, Warmenhoven, John W., Merchant, Michael J., Mackay, Ran I., and Kirkby, Karen J.

Abstract

Particle therapy is a growing cancer treatment modality worldwide. However, there still remains a number of unanswered questions considering differences in the biological response between particles and photons. These questions, and probing of biological mechanisms in general, necessitate experimental investigation. The “Infrastructure in Proton International Research” (INSPIRE) project was created to provide an infrastructure for European research, unify research efforts on the topic of proton and ion therapy across Europe, and to facilitate the sharing of information and resources. This work highlights the radiobiological capabilities of the INSPIRE partners, providing details of physics (available particle types and energies), biology (sample preparation and post-irradiation analysis), and researcher access (the process of applying for beam time). The collection of information reported here is designed to provide researchers both in Europe and worldwide with the tools required to select the optimal center for their research needs. We also highlight areas of redundancy in capabilities and suggest areas for future investment.

Published
2024

13. MAILED DOSIMETRY AUDIT OF ACTIVE SCANNING PROTON BEAMS IN TEN PROTON THERAPY CENTERS

Author

Davídková, Marie, primary, Ankjærgaard, C, additional, Andersen, C.E., additional, Dasu, A., additional, De Angelis, C., additional, De Marzi, Ludovic, additional, De Saint-Hubert, Marijke, additional, Ekendahl, Daniela, additional, Henthorn, Nicholas, additional, Michaelidesová, Anna Jelínek, additional, Knežević, Željka, additional, Krzempek, Dawid, additional, Kukolowicz, Pawel, additional, Liszka, Małgorzata, additional, Lorentini, Stefano, additional, Leite, Amelia Maia, additional, Majer, Marija, additional, Navrátil, Matěj, additional, Reniers, Brigitte, additional, Ślusarczyk-Kacprzyk, Wioletta, additional, Van Goethem, Marc Jan, additional, Vestergaard, Anne, additional, Vilches-Freixas, Gloria, additional, Vondráček, Vladimír, additional, Togno, Michele, additional, Stolarczyk, Liliana, additional, and Olko, Pawel, additional

Published
2022
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20. RADIATION DAMAGE TO DNA PLASMIDS IN THE PRESENCE OF BOROCAPTATES

Author

Jamborová, Zuzana, primary, Pachnerová Brabcová, Kateřina, additional, Jelínek Michaelidesová, Anna, additional, Zahradníček, Oldřich, additional, Danilová, Irina, additional, Ukraintsev, Egor, additional, Kundrát, Pavel, additional, Štěpán, Václav, additional, and Davídková, Marie, additional

Published
2022
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22. Out-of-Field Doses Produced by a Proton Scanning Beam Inside Pediatric Anthropomorphic Phantoms and Their Comparison With Different Photon Modalities

Author

Knežević, Željka, primary, Stolarczyk, Liliana, additional, Ambrožová, Iva, additional, Caballero-Pacheco, Miguel Á., additional, Davídková, Marie, additional, De Saint-Hubert, Marijke, additional, Domingo, Carles, additional, Jeleń, Kinga, additional, Kopeć, Renata, additional, Krzempek, Dawid, additional, Majer, Marija, additional, Miljanić, Saveta, additional, Mojżeszek, Natalia, additional, Romero-Expósito, Maite, additional, Martínez-Rovira, Immaculada, additional, Harrison, Roger M., additional, and Olko, Paweł, additional

Published
2022
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23. Proton-induced direct and indirect damage of plasmid DNA

Author

Vyšín, Luděk, Pachnerová Brabcová, Kateřina, Štěpán, Václav, Moretto-Capelle, Patrick, Bugler, Beatrix, Legube, Gaelle, Cafarelli, Pierre, Casta, Romain, Champeaux, Jean Philippe, Sence, Martine, Vlk, Martin, Wagner, Richard, Štursa, Jan, Zach, Václav, Incerti, Sebastien, Juha, Libor, and Davídková, Marie

Published
2015
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24. Out‐of‐field doses in pediatric craniospinal irradiations with 3D‐CRT, VMAT, and scanning proton radiotherapy: A phantom study

Author

Majer, Marija, primary, Ambrožová, Iva, additional, Davídková, Marie, additional, De Saint‐Hubert, Marijke, additional, Kasabašić, Mladen, additional, Knežević, Željka, additional, Kopeć, Renata, additional, Krzempek, Dawid, additional, Krzempek, Katarzyna, additional, Miljanić, Saveta, additional, Mojżeszek, Natalia, additional, Veršić, Ivan, additional, Stolarczyk, Liliana, additional, Harrison, Roger M., additional, and Olko, Paweł, additional

Published
2022
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29. Mapping the Future of Particle Radiobiology in Europe : The INSPIRE Project

Author

Henthorn, Nicholas T., Sokol, Olga, Durante, Marco, De Marzi, Ludovic, Pouzoulet, Frederic, Miszczyk, Justyna, Olko, Pawel, Brandenburg, Sytze, Van Goethem, Marc Jan, Barazzuol, Lara, Tambas, Makbule, Langendijk, Johannes A., Davídková, Marie, Vondráček, Vladimir, Bodenstein, Elisabeth, Pawelke, Joerg, Lomax, Antony J., Weber, Damien C., Dasu, Alexandru, Stenerlöw, Bo, Poulsen, Per R., Sørensen, Brita S., Grau, Cai, Sitarz, Mateusz K., Heuskin, Anne-Catherine, Lucas, Stephane, Warmenhoven, John W., Merchant, Michael J., Mackay, Ran I., Kirkby, Karen J., Henthorn, Nicholas T., Sokol, Olga, Durante, Marco, De Marzi, Ludovic, Pouzoulet, Frederic, Miszczyk, Justyna, Olko, Pawel, Brandenburg, Sytze, Van Goethem, Marc Jan, Barazzuol, Lara, Tambas, Makbule, Langendijk, Johannes A., Davídková, Marie, Vondráček, Vladimir, Bodenstein, Elisabeth, Pawelke, Joerg, Lomax, Antony J., Weber, Damien C., Dasu, Alexandru, Stenerlöw, Bo, Poulsen, Per R., Sørensen, Brita S., Grau, Cai, Sitarz, Mateusz K., Heuskin, Anne-Catherine, Lucas, Stephane, Warmenhoven, John W., Merchant, Michael J., Mackay, Ran I., and Kirkby, Karen J.

Abstract

Particle therapy is a growing cancer treatment modality worldwide. However, there still remains a number of unanswered questions considering differences in the biological response between particles and photons. These questions, and probing of biological mechanisms in general, necessitate experimental investigation. The "Infrastructure in Proton International Research" (INSPIRE) project was created to provide an infrastructure for European research, unify research efforts on the topic of proton and ion therapy across Europe, and to facilitate the sharing of information and resources. This work highlights the radiobiological capabilities of the INSPIRE partners, providing details of physics (available particle types and energies), biology (sample preparation and post-irradiation analysis), and researcher access (the process of applying for beam time). The collection of information reported here is designed to provide researchers both in Europe and worldwide with the tools required to select the optimal center for their research needs. We also highlight areas of redundancy in capabilities and suggest areas for future investment.

Published
2020
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31. Assessment of DNA damage with an adapted independent reaction time approach implemented in Geant4‐DNA for the simulation of diffusion‐controlled reactions between radio‐induced reactive species and a chromatin fiber

Author

Tran, Hoang Ngoc, primary, Ramos‐Méndez, José, additional, Shin, Wook‐Geun, additional, Perrot, Yann, additional, Faddegon, Bruce, additional, Okada, Shogo, additional, Karamitros, Mathieu, additional, Davídková, Marie, additional, Štěpán, Václav, additional, Incerti, Sébastien, additional, and Villagrasa, Carmen, additional

Published
2020
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33. Mapping the Future of Particle Radiobiology in Europe: The INSPIRE Project

Author

Henthorn, Nicholas T., primary, Sokol, Olga, additional, Durante, Marco, additional, De Marzi, Ludovic, additional, Pouzoulet, Frederic, additional, Miszczyk, Justyna, additional, Olko, Pawel, additional, Brandenburg, Sytze, additional, van Goethem, Marc Jan, additional, Barazzuol, Lara, additional, Tambas, Makbule, additional, Langendijk, Johannes A., additional, Davídková, Marie, additional, Vondráĉek, Vladimír, additional, Bodenstein, Elisabeth, additional, Pawelke, Joerg, additional, Lomax, Antony J., additional, Weber, Damien C., additional, Dasu, Alexandru, additional, Stenerlöw, Bo, additional, Poulsen, Per R., additional, Sørensen, Brita S., additional, Grau, Cai, additional, Sitarz, Mateusz K., additional, Heuskin, Anne-Catherine, additional, Lucas, Stephane, additional, Warmenhoven, John W., additional, Merchant, Michael J., additional, Mackay, Ran I., additional, and Kirkby, Karen J., additional

Published
2020
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34. In Vitro Comparison of Passive and Active Clinical Proton Beams

Author

Michaelidesová, Anna, primary, Vachelová, Jana, additional, Klementová, Jana, additional, Urban, Tomáš, additional, Pachnerová Brabcová, Kateřina, additional, Kaczor, Stanislav, additional, Falk, Martin, additional, Falková, Iva, additional, Depeš, Daniel, additional, Vondráček, Vladimír, additional, and Davídková, Marie, additional

Published
2020
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38. 498 - MAILED DOSIMETRY AUDIT OF ACTIVE SCANNING PROTON BEAMS IN TEN PROTON THERAPY CENTERS

Author

Davídková, Marie, Ankjærgaard, C, Andersen, C.E., Dasu, A., De Angelis, C., De Marzi, Ludovic, De Saint-Hubert, Marijke, Ekendahl, Daniela, Henthorn, Nicholas, Michaelidesová, Anna Jelínek, Knežević, Željka, Krzempek, Dawid, Kukolowicz, Pawel, Liszka, Małgorzata, Lorentini, Stefano, Leite, Amelia Maia, Majer, Marija, Navrátil, Matěj, Reniers, Brigitte, Ślusarczyk-Kacprzyk, Wioletta, Van Goethem, Marc Jan, Vestergaard, Anne, Vilches-Freixas, Gloria, Vondráček, Vladimír, Togno, Michele, Stolarczyk, Liliana, and Olko, Pawel

Published
2022
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39. Out-of-field dose measurement in photon and proton craniospinal irradiation of paediatric patients – EURADOS WG9 phantom study

Author

Majer, Marija, Ambrožová, Iva, Davídková, Marie, De Saint-Hubert, Marijke, Knežević, Željka, Miljanić, Saveta, Mojzeszek, Natalia, Rajevac, Vedran, Stolarczyk, Liliana, Olko, Pawel, and Harrison, Roger M

Subjects
Radiation Science, out-of-field dose measuremen, photon and proton craniospinal irradiation, Biophysics and Medical Physics
Abstract

Background and Objectives Out-of-field doses, caused by stray radiation, may increase secondary cancer risk for radiotherapy patients. Children are of particular concern due to high radiosensitivity and long-life expectancy. Therefore out-of-field dose measurement of different radiotherapy techniques is extremely important for risk assessment and radiation protection. Craniospinal (CS) irradiation increased tremendously survival rate for the patients with medulloblastoma which is the most common malignant brain tumour in children. This study, carried out within EURADOS Working Group 9 (Radiation Dosimetry in Radiotherapy), evaluates and compares out-of-field doses for paediatric medulloblastoma treatment using photon and proton CS irradiation. Materials and Methods Photon and proton irradiations were performed on Siemens Artiste linac at UCHCSM UHT (Zagreb) using 3D conformal radiotherapy (3D-CRT) and at CCB (IFJ, Krakow) using pencil beam scanning (PBS) technique (IBA Proteus 235 gantry) respectively. CS treatments of the same target volume (whole brain and spinal cord irradiation + 0.5 cm margin) in CIRS anthropomorphic phantoms representing 5-year and 10-year old children were performed. For 3D-CRT, 6 MV photon beams were used for brain and 6 MV + 18 MV for spinal cord irradiation. The stray doses were measured with three types of thermoluminescent detectors (MTS-7: 7LiF (Mg, Ti) and MTS-6: 6LiF (Mg, Ti) for 10-year ; MCP-n: LiF(Mg, Cu, P) for 5-year) and radiophotoluminescent (RPL) detector type GD-352M. The neutron contribution during PBS was determined with poly-allyl-diglycol-carbonate (PADC) nuclear track detector in 10-year phantom. For 3D-CRT dosimeters were placed in all out-of-field organs, while for PBS dosimeters were put in the selected radiosensitive organs close to spinal cord. Results and Discussion For out-of-field doses during 3D-CRT CS radiotherapy excellent agreement between RPL and MCP-n detectors was confirmed: the RPL/MCP ratio for the same point in 5-year phantom was on average 1.02  0.15. Due to the use of 18 MV photon beams, higher doses were measured with MTS-6 than with MTS-7: the highest gamma-equivalent neutron dose per target dose in 10-year phantom were 293 and 181 mGy/Gy for esophagus and TL/spine respectively. Mean organ doses for both phantoms were comparable with exception of pancreas, stomach and four organs (uterus, adrenals, mandible, testes) with a factor 3.5, 2 and 1.5 higher values for 5-year phantom. This finding is expected due to the closer proximity of organs to the central spine axis in the 5-year phantom. Comparison of stray radiation doses for proton and photon radiotherapy for 10-year phantom is shown in Figure 1. For points in the selected organs shown in Figure 1, gamma doses (RPL) are 2-3 orders of magnitude lower for PBS in comparison to 3D-CRT (MTS-7). For PBS, measured neutron dose equivalents (PADC) are a factor of 5 higher than gamma doses (RPL). In other points (closer to the central spinal axis) of the selected organs (including lungs, thyroid, esophagus), PADC were over-irradiated while measured gamma doses showed a factor 2 to 2000 lower values in comparison to 3D-CRT. Conclusion For measured points CS treatment with protons showed lower out-of-field doses for paediatric patients in comparison to photons.

Published
2019

47. Track structure modeling in liquid water: A review of the Geant4-DNA very low energy extension of the Geant4 Monte Carlo simulation toolkit

Author

Bernal, Mario A., Bordage, Marie Claude, Brown, Jeremy Michael Cooney, Davídková, Marie, Delage, E., El Bitar, Ziad Ei, Enger, Shirin A., Francis, Ziad, Guatelli, Susanna, Ivanchenko, Vladimir N., Karamitros, Mathieu, Kyriakou, Ioanna, Maigne, Lydia, Meylan, Sylvain, Murakami, Kouichi, Okada, Shogo, Payno, H., Perrot, Yann, Petrović, Ivan M., Pham, Q. T., Ristić-Fira, Aleksandra, Sasaki, Takashi, Stepan, Vaclav, Tran, Ngoc Hoang, Villagrasa, Carmen, and Incerti, Sebastien

Subjects
Ionizing radiation, Geant4-DNA, Radiolysis, Radiobiology, Monte Carlo
Abstract

Understanding the fundamental mechanisms involved in the induction of biological damage by ionizing radiation remains a major challenge of todays radiobiology research. The Monte Carlo simulation of physical, physicochemical and chemical processes involved may provide a powerful tool for the simulation of early damage induction. The Geant4-DNA extension of the general purpose Monte Carlo Geant4 simulation toolkit aims to provide the scientific community with an open source access platform for the mechanistic simulation of such early damage. This paper presents the most recent review of the Geant4-DNA extension, as available to Geant4 users since June 2015 (release 10.2 Beta). In particular, the review includes the description of new physical models for the description of electron elastic and inelastic interactions in liquid water, as well as new examples dedicated to the simulation of physicochemical and chemical stages of water radiolysis. Several implementations of geometrical models of biological targets are presented as well, and the list of Geant4-DNA examples is described.

Published
2015

48. HOW DETECTION OF PLASMID DNA FRAGMENTATION AFFECTS RADIATION STRAND BREAK YIELDS.

Author

Brabcová, Kateřina Pachnerová, Sihver, Lembit, Ukraintsev, Egor, Štěpán, Václav, and Davídková, Marie

Subjects
PLASMIDS, DNA, ELECTROPHORESIS, HEAVY ions, RADIOBIOLOGY
Abstract

A compromised detection of radiation-induced plasmid DNA fragments results in underestimation of calculated damage yields. Electrophoretic methods are easy and cheap, but they can only detect a part of the fragments, neglecting the shortest ones. These can be detected with atomic force microscopy, but at the expense of time and price. Both methods were used to investigate their capabilities to detect the DNA fragments induced by high-energetic heavy ions. The results were taken into account in calculations of radiation-induced yields of single and double strand breaks. It was estimated that the double strand break yield is twice as high when the fragments are at least partially detected with the agarose electrophoresis, compared to when they were completely omitted. Further increase by 13% was observed when the measured fragments were corrected for the fraction of the shortest fragments up to 300 base pairs, as detected with the atomic force microscopy. The effect of fragment detection on the single strand break yield was diminished. [ABSTRACT FROM AUTHOR]

Published
2019
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49. Simulating radial dose of ion tracks in liquid water simulated with Geant4-DNA: A comparative study

Author

Incerti, Sebastien, Psaltaki, Maria G., Gillet, Pierre, Barberet, Ph., Bardies, M., Bernal, Mario A., Bordage, Marie Claude, Breton, Vincent, Davídková, Marie, Delage, E., El Bitar, Ziad Ei, Francis, Ziad, Guatelli, Susanna, Ivanchenko, A., Ivanchenko, Vladimir, Karamitros, Mathieu, Lee, Sebyeong, Maigne, Lydia, Meylan, Sylvain, Murakami, Kouichi, Nieminen, Petteri H., Payno, H., Perrot, Yann, Petrović, Ivan M., Pham, Q. T., Ristić-Fira, Aleksandra, Santin, Giovanni, Sasaki, Takashi, Seznec, Herve, Shin, Jae-ik, Stepan, Vaclav, Tran, Ngoc Hoang, Villagrasa, Carmen, Geant4-DNA Collaboration, Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), National Technical University of Athens [Athens] (NTUA), Institut Universitaire du Cancer de Toulouse - Oncopole (IUCT Oncopole - UMR 1037), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Institut National de la Santé et de la Recherche Médicale (INSERM), Instituto de Fisica 'Gleb Wataghin' (INSTITUTO DE FISICA 'GLEB WATAGHIN'), Universidade Estadual de Campinas (UNICAMP), Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Department of Radiation Dosimetry, Nuclear Physics Institute of the AS CR, Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Department of Physics, Faculty of Sciences, Université Saint-Joseph de Beyrouth (USJ), Centre for Medical Radiation Physics, University of Wollongong [Australia], Geant4 Associates International (G4AI), Ecoanalytica, Institut de Neurosciences cognitives et intégratives d'Aquitaine (INCIA), Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1-SFR Bordeaux Neurosciences-Centre National de la Recherche Scientifique (CNRS), Proton Therapy Center, National Cancer Center Korea, Institut de Radioprotection et de Sûreté Nucléaire (IRSN), KEK (High energy accelerator research organization), European Space Research and Technology Centre (ESTEC), European Space Agency (ESA), Vinča Institute of Nuclear Sciences, University of Belgrade [Belgrade], Ton Duc Thang University [Hô-Chi-Minh-City], Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM), Universidade Estadual de Campinas = University of Campinas (UNICAMP), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1 (UB)-SFR Bordeaux Neurosciences-Centre National de la Recherche Scientifique (CNRS), and Agence Spatiale Européenne = European Space Agency (ESA)

Subjects
Nuclear and High Energy Physics, Work (thermodynamics), Radiation transport, Physics::Medical Physics, Reference data (financial markets), Monte Carlo method, Ion, Deposition (phase transition), Statistical physics, Instrumentation, Monte Carlo, Physics, Energy depositions, [PHYS]Physics [physics], Geant4-DNA, Ion track, Geant4 dnas, Monte Carlo methods, Liquids, DNA, Analytical calculation, Monte- carlo simulations, Charged particle, Computational physics, Comparative studies, Liquid water, Dose, Dynamic Monte Carlo method
Abstract

International audience; An accurate modeling of radial energy deposition around ion tracks is a key requirement of radiation transport software used for simulations in radiobiology at the sub-cellular scale. The work presented in this paper is part of the on-going benchmarking of the "Geant4-DNA" physics processes and models, which are available in the Geant4 Monte Carlo simulation toolkit for the low energy transport of particles in liquid water. We present for the first time radial dose distributions of incident ion tracks simulated with "Geant4-DNA". Simulation results are compared to other results available in the literature, obtained from analytical calculations, step-by-step Monte Carlo simulations and measurements. They show a reasonable agreement with reference data. © 2014 Elsevier B.V. All rights reserved.

Published
2014

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