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1. Alcohol drinking and head and neck cancer risk: the joint effect of intensity and duration

Author

Di Credico, Gioia, Polesel, Jerry, Dal Maso, Luigino, Pauli, Francesco, Torelli, Nicola, Luce, Daniele, Radoï, Loredana, Matsuo, Keitaro, Serraino, Diego, Brennan, Paul, Holcatova, Ivana, Ahrens, Wolfgang, Lagiou, Pagona, Canova, Cristina, Richiardi, Lorenzo, Healy, Claire M, Kjaerheim, Kristina, Conway, David I, Macfarlane, Gary J, Thomson, Peter, Agudo, Antonio, Znaor, Ariana, Franceschi, Silvia, Herrero, Rolando, Toporcov, Tatiana N, Moyses, Raquel A, Muscat, Joshua, Negri, Eva, Vilensky, Marta, Fernandez, Leticia, Curado, Maria Paula, Menezes, Ana, Daudt, Alexander W, Koifman, Rosalina, Wunsch-Filho, Victor, Olshan, Andrew F, Zevallos, Jose P, Sturgis, Erich M, Li, Guojun, Levi, Fabio, Zhang, Zuo-Feng, Morgenstern, Hal, Smith, Elaine, Lazarus, Philip, La Vecchia, Carlo, Garavello, Werner, Chen, Chu, Schwartz, Stephen M, Zheng, Tongzhang, Vaughan, Thomas L, Kelsey, Karl, McClean, Michael, Benhamou, Simone, Hayes, Richard B, Purdue, Mark P, Gillison, Maura, Schantz, Stimson, Yu, Guo-Pei, Chuang, Shu-Chun, Boffetta, Paolo, Hashibe, Mia, Yuan-Chin, Amy Lee, and Edefonti, Valeria

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Dental/Oral and Craniofacial Disease, Clinical Research, Cancer, Substance Misuse, Clinical Trials and Supportive Activities, Digestive Diseases, Prevention, Rare Diseases, Alcoholism, Alcohol Use and Health, Tobacco Smoke and Health, Tobacco, 2.2 Factors relating to the physical environment, Oral and gastrointestinal, Good Health and Well Being, Adolescent, Adult, Aged, Aged, 80 and over, Alcohol Drinking, Case-Control Studies, Female, Head and Neck Neoplasms, Humans, Laryngeal Neoplasms, Male, Middle Aged, Mouth Neoplasms, Oropharyngeal Neoplasms, Risk Factors, Severity of Illness Index, Smoking, Time Factors, Young Adult, Public Health and Health Services, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

BackgroundAlcohol is a well-established risk factor for head and neck cancer (HNC). This study aims to explore the effect of alcohol intensity and duration, as joint continuous exposures, on HNC risk.MethodsData from 26 case-control studies in the INHANCE Consortium were used, including never and current drinkers who drunk ≤10 drinks/day for ≤54 years (24234 controls, 4085 oral cavity, 3359 oropharyngeal, 983 hypopharyngeal and 3340 laryngeal cancers). The dose-response relationship between the risk and the joint exposure to drinking intensity and duration was investigated through bivariate regression spline models, adjusting for potential confounders, including tobacco smoking.ResultsFor all subsites, cancer risk steeply increased with increasing drinks/day, with no appreciable threshold effect at lower intensities. For each intensity level, the risk of oral cavity, hypopharyngeal and laryngeal cancers did not vary according to years of drinking, suggesting no effect of duration. For oropharyngeal cancer, the risk increased with durations up to 28 years, flattening thereafter. The risk peaked at the higher levels of intensity and duration for all subsites (odds ratio = 7.95 for oral cavity, 12.86 for oropharynx, 24.96 for hypopharynx and 6.60 for larynx).ConclusionsPresent results further encourage the reduction of alcohol intensity to mitigate HNC risk.

Published
2020

2. Age at start of using tobacco on the risk of head and neck cancer: Pooled analysis in the International Head and Neck Cancer Epidemiology Consortium (INHANCE)

Author

Chang, Chun-Pin, Chang, Shen-Chih, Chuang, Shu-Chun, Berthiller, Julien, Ferro, Gilles, Matsuo, Keitaro, Wünsch-Filho, Victor, Toporcov, Tatiana N, de Carvalho, Marcos Brasilino, La Vecchia, Carlo, Olshan, Andrew F, Zevallos, Jose P, Serraino, Diego, Muscat, Joshua, Sturgis, Erich M, Li, Guojun, Morgenstern, Hal, Levi, Fabio, Dal Maso, Luigino, Smith, Elaine, Kelsey, Karl, McClean, Michael, Vaughan, Thomas L, Lazarus, Philip, Ramroth, Heribert, Chen, Chu, Schwartz, Stephen M, Winn, Deborah M, Bosetti, Cristina, Edefonti, Valeria, Garavello, Werner, Negri, Eva, Hayes, Richard B, Purdue, Mark P, Boccia, Stefania, Cadoni, Gabriella, Shangina, Oxana, Koifman, Rosalina, Curado, Maria Paula, Vilensky, Marta, Swiatkowska, Beata, Herrero, Rolando, Franceschi, Silvia, Benhamou, Simone, Fernandez, Leticia, Menezes, Ana MB, Daudt, Alexander W, Mates, Dana, Schantz, Stimson, Yu, Guo-Pei, Lissowska, Jolanta, Brenner, Hermann, Fabianova, Eleonora, Rudnai, Peter, Brennan, Paul, Boffetta, Paolo, Zhang, Zuo-Feng, Hashibe, Mia, and Lee, Yuan-Chin Amy

Subjects
Biomedical and Clinical Sciences, Epidemiology, Health Services and Systems, Health Sciences, Public Health, Oncology and Carcinogenesis, Tobacco, Tobacco Smoke and Health, Substance Misuse, Prevention, Cancer, Dental/Oral and Craniofacial Disease, Rare Diseases, Good Health and Well Being, Adult, Age Factors, Aged, Case-Control Studies, Female, Head and Neck Neoplasms, Humans, Male, Middle Aged, Risk Factors, Tobacco Products, Age at start of tobacco use, Head and neck cancer, Oral cancer, Oropharyngeal cancer, Hypopharyngeal cancer, Laryngeal cancer, Public Health and Health Services, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

BackgroundTobacco use is a well-established risk factor for head and neck cancer (HNC). However, less is known about the potential impact of exposure to tobacco at an early age on HNC risk.MethodsWe analyzed individual-level data on ever tobacco smokers from 27 case-control studies (17,146 HNC cases and 17,449 controls) in the International Head and Neck Cancer Epidemiology (INHANCE) consortium. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using random-effects logistic regression models.ResultsWithout adjusting for tobacco packyears, we observed that younger age at starting tobacco use was associated with an increased HNC risk for ever smokers (OR

Published
2019

3. Joint effects of intensity and duration of cigarette smoking on the risk of head and neck cancer: A bivariate spline model approach

Author

Di Credico, Gioia, Edefonti, Valeria, Polesel, Jerry, Pauli, Francesco, Torelli, Nicola, Serraino, Diego, Negri, Eva, Luce, Daniele, Stucker, Isabelle, Matsuo, Keitaro, Brennan, Paul, Vilensky, Marta, Fernandez, Leticia, Curado, Maria Paula, Menezes, Ana, Daudt, Alexander W, Koifman, Rosalina, Wunsch-Filho, Victor, Holcatova, Ivana, Ahrens, Wolfgang, Lagiou, Pagona, Simonato, Lorenzo, Richiardi, Lorenzo, Healy, Claire, Kjaerheim, Kristina, Conway, David I, Macfarlane, Tatiana V, Thomson, Peter, Agudo, Antonio, Znaor, Ariana, Rios, Leonardo F Boaventura, Toporcov, Tatiana N, Franceschi, Silvia, Herrero, Rolando, Muscat, Joshua, Olshan, Andrew F, Zevallos, Jose P, La Vecchia, Carlo, Winn, Deborah M, Sturgis, Erich M, Li, Guojun, Fabianova, Eleonora, Lissowska, Jolanda, Mates, Dana, Rudnai, Peter, Shangina, Oxana, Swiatkowska, Beata, Moysich, Kirsten, Zhang, Zuo-Feng, Morgenstern, Hal, Levi, Fabio, Smith, Elaine, Lazarus, Philip, Bosetti, Cristina, Garavello, Werner, Kelsey, Karl, McClean, Michael, Ramroth, Heribert, Chen, Chu, Schwartz, Stephen M, Vaughan, Thomas L, Zheng, Tongzhang, Menvielle, Gwenn, Boccia, Stefania, Cadoni, Gabriella, Hayes, Richard B, Purdue, Mark, Gillison, Maura, Schantz, Stimson, Yu, Guo-Pei, Brenner, Hermann, D'Souza, Gypsyamber, Gross, Neil D, Chuang, Shu-Chun, Boffetta, Paolo, Hashibe, Mia, Lee, Yuan-Chin Amy, and Dal Maso, Luigino

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Tobacco Smoke and Health, Rare Diseases, Prevention, Dental/Oral and Craniofacial Disease, Substance Misuse, Tobacco, Cancer, 2.2 Factors relating to the physical environment, Good Health and Well Being, Adult, Aged, Aged, 80 and over, Case-Control Studies, Cigarette Smoking, Female, Head and Neck Neoplasms, Humans, Male, Middle Aged, Risk Factors, Bivariate spline models, Cigarette smoking duration, Cigarette smoking intensity, Head and neck cancer, INHANCE, Laryngeal cancer, Oral cavity and pharyngeal cancers, Dentistry, Public Health and Health Services, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

ObjectivesThis study aimed at re-evaluating the strength and shape of the dose-response relationship between the combined (or joint) effect of intensity and duration of cigarette smoking and the risk of head and neck cancer (HNC). We explored this issue considering bivariate spline models, where smoking intensity and duration were treated as interacting continuous exposures.Materials and methodsWe pooled individual-level data from 33 case-control studies (18,260 HNC cases and 29,844 controls) participating in the International Head and Neck Cancer Epidemiology (INHANCE) consortium. In bivariate regression spline models, exposures to cigarette smoking intensity and duration (compared with never smokers) were modeled as a linear piecewise function within a logistic regression also including potential confounders. We jointly estimated the optimal knot locations and regression parameters within the Bayesian framework.ResultsFor oral-cavity/pharyngeal (OCP) cancers, an odds ratio (OR) >5 was reached after 30 years in current smokers of ∼20 or more cigarettes/day. Patterns of OCP cancer risk in current smokers differed across strata of alcohol intensity. For laryngeal cancer, ORs >20 were found for current smokers of ≥20 cigarettes/day for ≥30  years. In former smokers who quit ≥10  years ago, the ORs were approximately halved for OCP cancers, and ∼1/3 for laryngeal cancer, as compared to the same levels of intensity and duration in current smokers.ConclusionReferring to bivariate spline models, this study better quantified the joint effect of intensity and duration of cigarette smoking on HNC risk, further stressing the need of smoking cessation policies.

Published
2019

4. Mouthwash use and cancer of the head and neck

Author

Boffetta, Paolo, Hayes, Richard B, Sartori, Samantha, Lee, Yuan-Chin A, Muscat, Joshua, Olshan, Andrew, Winn, Deborah M, Castellsagué, Xavier, Zhang, Zuo-Feng, Morgenstern, Hal, Chen, Chu, Schwartz, Stephen M, Vaughan, Thomas L, Wunsch-Filho, Victor, Purdue, Mark, Koifman, Sergio, Curado, Maria P, Vilensky, Marta, Gillison, Maura, Fernandez, Leticia, Menezes, Ana, Daudt, Alexander W, Schantz, Stimson, Yu, Guopei, D’Souza, Gypsyamber, Haddad, Robert I, La Vecchia, Carlo, and Hashibe, Mia

Subjects
Health Services and Systems, Biomedical and Clinical Sciences, Health Sciences, Digestive Diseases, Rare Diseases, Cancer, Alcoholism, Alcohol Use and Health, Tobacco, Tobacco Smoke and Health, Dental/Oral and Craniofacial Disease, Substance Misuse, 2.2 Factors relating to the physical environment, Oral and gastrointestinal, Good Health and Well Being, Adult, Case-Control Studies, Female, Follow-Up Studies, Head and Neck Neoplasms, Humans, International Agencies, Male, Meta-Analysis as Topic, Mouthwashes, Prevalence, Prognosis, Retrospective Studies, Risk Factors, alcohol, head and neck cancer, laryngeal cancer, mouthwash, oral cancer, pharyngeal cancer, Oncology and Carcinogenesis, Public Health and Health Services, Oncology & Carcinogenesis, Oncology and carcinogenesis, Public health
Abstract

Most mouthwashes contain alcohol, a known cause of head and neck cancer (oral cavity, pharynx, larynx), likely through the carcinogenic activity of acetaldehyde, formed in the oral cavity from alcohol. We carried out a pooled analysis of 8981 cases of head and neck cancer and 10 090 controls from 12 case-control studies with comparable information on mouthwash use in the International Head and Neck Cancer Epidemiology Consortium. Logistic regression was used to assess the association of mouthwash use with cancers of the oral cavity, oropharynx, hypopharynx, and larynx, adjusting for study, age, sex, pack-years of tobacco smoking, number of alcoholic drinks/day, and education. Compared with never users of mouthwash, the odds ratio (OR) of all head and neck cancers was 1.01 [95% confidence interval (CI): 0.94-1.08] for ever users, based on 12 studies. The corresponding ORs of cancer of the oral cavity and oropharynx were 1.11 (95% CI: 1.00-1.23) and 1.28 (95% CI: 1.06-1.56), respectively. OR for all head and neck cancer was 1.15 (95% CI: 1.01-1.30) for use for more than 35 years, based on seven studies (P for linear trend=0.01), and OR 1.31 (95% CI: 1.09-1.58) for use more than one per day, based on five studies (P for linear trend

Published
2016

5. Low frequency of cigarette smoking and the risk of head and neck cancer in the INHANCE consortium pooled analysis

Author

Berthiller, Julien, Straif, Kurt, Agudo, Antonio, Ahrens, Wolfgang, dos Santos, Alexandre Bezerra, Boccia, Stefania, Cadoni, Gabriella, Canova, Cristina, Castellsague, Xavier, Chen, Chu, Conway, David, Curado, Maria Paula, Dal Maso, Luigino, Daudt, Alexander W, Fabianova, Eleonora, Fernandez, Leticia, Franceschi, Silvia, Fukuyama, Erica E, Hayes, Richard B, Healy, Claire, Herrero, Rolando, Holcatova, Ivana, Kelsey, Karl, Kjaerheim, Kristina, Koifman, Sergio, Lagiou, Pagona, La Vecchia, Carlo, Lazarus, Philip, Levi, Fabio, Lissowska, Jolanta, Macfarlane, Tatiana, Mates, Dana, McClean, Michael, Menezes, Ana, Merletti, Franco, Morgenstern, Hal, Muscat, Joshua, Olshan, Andrew F, Purdue, Mark, Ramroth, Heribert, Rudnai, Peter, Schwartz, Stephen M, Serraino, Diego, Shangina, Oxana, Smith, Elaine, Sturgis, Erich M, Szeszenia-Dabrowska, Neonila, Thomson, Peter, Vaughan, Thomas L, Vilensky, Marta, Wei, Qingyi, Winn, Deborah M, Wünsch-Filho, Victor, Zhang, Zuo-Feng, Znaor, Ariana, Ferro, Gilles, Brennan, Paul, Boffetta, Paolo, Hashibe, Mia, and Lee, Yuan-Chin Amy

Subjects
Health Services and Systems, Public Health, Health Sciences, Substance Misuse, Tobacco Smoke and Health, Dental/Oral and Craniofacial Disease, Alcoholism, Alcohol Use and Health, Cancer, Rare Diseases, Tobacco, 3.1 Primary prevention interventions to modify behaviours or promote wellbeing, Good Health and Well Being, Adult, Aged, Alcohol Drinking, Case-Control Studies, Cigarette Smoking, Female, Head and Neck Neoplasms, Humans, Logistic Models, Male, Middle Aged, Odds Ratio, Risk Factors, Head and neck cancer, low frequency cigarette smoking, risk factors, pooled analysis, Statistics, Public Health and Health Services, Epidemiology, Public health
Abstract

BackgroundCigarette smoking is a major risk factor for head and neck cancer (HNC). To our knowledge, low cigarette smoking (0-3, >3-5, >5-10 cigarettes per day.ResultsSmoking >0-3 cigarettes per day was associated with a 50% increased risk of HNC in the study population [odds ratio (OR) = 1.52, 95% confidence interval (CI): (1.21, 1.90). Smoking >3-5 cigarettes per day was associated in each subgroup from OR = 2.01 (95% CI: 1.22, 3.31) among never alcohol drinkers to OR = 2.74 (95% CI: 2.01, 3.74) among women and in each cancer site, particularly laryngeal cancer (OR = 3.48, 95% CI: 2.40, 5.05). However, the observed increased risk of HNC for low smoking frequency was not found among smokers with smoking duration shorter than 20 years.ConclusionOur results suggest a public health message that low frequency of cigarette consumption contributes to the development of HNC. However, smoking duration seems to play at least an equal or a stronger role in the development of HNC.

Published
2016

6. Estimating and explaining the effect of education and income on head and neck cancer risk: INHANCE consortium pooled analysis of 31 case‐control studies from 27 countries

Author

Conway, David I, Brenner, Darren R, McMahon, Alex D, Macpherson, Lorna MD, Agudo, Antonio, Ahrens, Wolfgang, Bosetti, Cristina, Brenner, Hermann, Castellsague, Xavier, Chen, Chu, Curado, Maria Paula, Curioni, Otávio A, Dal Maso, Luigino, Daudt, Alexander W, de Gois Filho, José F, D'Souza, Gypsyamber, Edefonti, Valeria, Fabianova, Eleonora, Fernandez, Leticia, Franceschi, Silvia, Gillison, Maura, Hayes, Richard B, Healy, Claire M, Herrero, Rolando, Holcatova, Ivana, Jayaprakash, Vijayvel, Kelsey, Karl, Kjaerheim, Kristina, Koifman, Sergio, La Vecchia, Carlo, Lagiou, Pagona, Lazarus, Philip, Levi, Fabio, Lissowska, Jolanta, Luce, Daniele, Macfarlane, Tatiana V, Mates, Dana, Matos, Elena, McClean, Michael, Menezes, Ana M, Menvielle, Gwenn, Merletti, Franco, Morgenstern, Hal, Moysich, Kirsten, Müller, Heiko, Muscat, Joshua, Olshan, Andrew F, Purdue, Mark P, Ramroth, Heribert, Richiardi, Lorenzo, Rudnai, Peter, Schantz, Stimson, Schwartz, Stephen M, Shangina, Oxana, Simonato, Lorenzo, Smith, Elaine, Stucker, Isabelle, Sturgis, Erich M, Szeszenia‐Dabrowska, Neonila, Talamini, Renato, Thomson, Peter, Vaughan, Thomas L, Wei, Qingyi, Winn, Deborah M, Wunsch‐Filho, Victor, Yu, Guo‐Pei, Zhang, Zuo‐Feng, Zheng, Tongzhang, Znaor, Ariana, Boffetta, Paolo, Chuang, Shu‐Chun, Ghodrat, Marianoosh, Lee, Yuan‐Chin Amy, Hashibe, Mia, and Brennan, Paul

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Substance Misuse, Rare Diseases, Behavioral and Social Science, Dental/Oral and Craniofacial Disease, Cancer, Prevention, Tobacco, Tobacco Smoke and Health, Reduced Inequalities, Good Health and Well Being, Alcohol Drinking, Case-Control Studies, Education, Female, Follow-Up Studies, Global Health, Head and Neck Neoplasms, Humans, Income, Male, Meta-Analysis as Topic, Middle Aged, Prognosis, Risk Factors, Smoking, Socioeconomic Factors, head and neck cancer, socioeconomic inequalities, epidemiology, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

Low socioeconomic status has been reported to be associated with head and neck cancer risk. However, previous studies have been too small to examine the associations by cancer subsite, age, sex, global region and calendar time and to explain the association in terms of behavioral risk factors. Individual participant data of 23,964 cases with head and neck cancer and 31,954 controls from 31 studies in 27 countries pooled with random effects models. Overall, low education was associated with an increased risk of head and neck cancer (OR = 2.50; 95% CI = 2.02 - 3.09). Overall one-third of the increased risk was not explained by differences in the distribution of cigarette smoking and alcohol behaviors; and it remained elevated among never users of tobacco and nondrinkers (OR = 1.61; 95% CI = 1.13 - 2.31). More of the estimated education effect was not explained by cigarette smoking and alcohol behaviors: in women than in men, in older than younger groups, in the oropharynx than in other sites, in South/Central America than in Europe/North America and was strongest in countries with greater income inequality. Similar findings were observed for the estimated effect of low versus high household income. The lowest levels of income and educational attainment were associated with more than 2-fold increased risk of head and neck cancer, which is not entirely explained by differences in the distributions of behavioral risk factors for these cancers and which varies across cancer sites, sexes, countries and country income inequality levels.

Published
2015

7. Risk factors for head and neck cancer in young adults: a pooled analysis in the INHANCE consortium

Author

Toporcov, Tatiana Natasha, Znaor, Ariana, Zhang, Zuo-Feng, Yu, Guo-Pei, Winn, Deborah M, Wei, Qingyi, Vilensky, Marta, Vaughan, Thomas, Thomson, Peter, Talamini, Renato, Szeszenia-Dabrowska, Neonila, Sturgis, Erich M, Smith, Elaine, Shangina, Oxana, Schwartz, Stephen M, Schantz, Stimson, Rudnai, Peter, Richiardi, Lorenzo, Ramroth, Heribert, Purdue, Mark P, Olshan, Andrew F, Eluf-Neto, José, Muscat, Joshua, Moyses, Raquel Ajub, Morgenstern, Hal, Menezes, Ana, McClean, Michael, Matsuo, Keitaro, Mates, Dana, Macfarlane, Tatiana V, Lissowska, Jolanta, Levi, Fabio, Lazarus, Philip, La Vecchia, Carlo, Lagiou, Pagona, Koifman, Sergio, Kjaerheim, Kristina, Kelsey, Karl, Holcatova, Ivana, Herrero, Rolando, Healy, Claire, Hayes, Richard B, Franceschi, Silvia, Fernandez, Leticia, Fabianova, Eleonora, Daudt, Alexander W, Curioni, Otávio Alberto, Maso, Luigino Dal, Curado, Maria Paula, Conway, David I, Chen, Chu, Castellsague, Xavier, Canova, Cristina, Cadoni, Gabriella, Brennan, Paul, Boccia, Stefania, Antunes, José Leopoldo Ferreira, Ahrens, Wolfgang, Agudo, Antonio, Boffetta, Paolo, Hashibe, Mia, Lee, Yuan-Chin Amy, and Filho, Victor Wünsch

Subjects
Health Services and Systems, Health Sciences, Rare Diseases, Aging, Dental/Oral and Craniofacial Disease, Tobacco, Prevention, Cancer, Tobacco Smoke and Health, Clinical Research, Good Health and Well Being, Adult, Age Factors, Alcohol Drinking, Case-Control Studies, Female, Genetic Predisposition to Disease, Head and Neck Neoplasms, Humans, Incidence, Male, Middle Aged, Odds Ratio, Registries, Risk Factors, Sex Factors, Smoking, Head and neck neoplasms, adult, smoking, alcohol drinking, diet, Statistics, Public Health and Health Services, Epidemiology, Public health
Abstract

BackgroundIncreasing incidence of head and neck cancer (HNC) in young adults has been reported. We aimed to compare the role of major risk factors and family history of cancer in HNC in young adults and older patients.MethodsWe pooled data from 25 case-control studies and conducted separate analyses for adults ≤ 45 years old ('young adults', 2010 cases and 4042 controls) and >45 years old ('older adults', 17700 cases and 22 704 controls). Using logistic regression with studies treated as random effects, we estimated adjusted odds ratios (ORs) and 95% confidence intervals (CIs).ResultsThe young group of cases had a higher proportion of oral tongue cancer (16.0% in women; 11.0% in men) and unspecified oral cavity / oropharynx cancer (16.2%; 11.1%) and a lower proportion of larynx cancer (12.1%; 16.6%) than older adult cases. The proportions of never smokers or never drinkers among female cases were higher than among male cases in both age groups. Positive associations with HNC and duration or pack-years of smoking and drinking were similar across age groups. However, the attributable fractions (AFs) for smoking and drinking were lower in young when compared with older adults (AFs for smoking in young women, older women, young men and older men, respectively, = 19.9% (95% CI=9.8%, 27.9%), 48.9% (46.6%, 50.8%), 46.2% (38.5%, 52.5%), 64.3% (62.2%, 66.4%); AFs for drinking=5.3% (-11.2%, 18.0%), 20.0% (14.5%, 25.0%), 21.5% (5.0%, 34.9%) and 50.4% (46.1%, 54.3%). A family history of early-onset cancer was associated with HNC risk in the young [OR=2.27 (95% CI=1.26, 4.10)], but not in the older adults [OR=1.10 (0.91, 1.31)]. The attributable fraction for family history of early-onset cancer was 23.2% (8.60% to 31.4%) in young compared with 2.20% (-2.41%, 5.80%) in older adults.ConclusionsDifferences in HNC aetiology according to age group may exist. The lower AF of cigarette smoking and alcohol drinking in young adults may be due to the reduced length of exposure due to the lower age. Other characteristics, such as those that are inherited, may play a more important role in HNC in young adults compared with older adults.

Published
2015

8. Adult height and head and neck cancer: a pooled analysis within the INHANCE Consortium

Author

Leoncini, Emanuele, Ricciardi, Walter, Cadoni, Gabriella, Arzani, Dario, Petrelli, Livia, Paludetti, Gaetano, Brennan, Paul, Luce, Daniele, Stucker, Isabelle, Matsuo, Keitaro, Talamini, Renato, La Vecchia, Carlo, Olshan, Andrew F, Winn, Deborah M, Herrero, Rolando, Franceschi, Silvia, Castellsague, Xavier, Muscat, Joshua, Morgenstern, Hal, Zhang, Zuo-Feng, Levi, Fabio, Dal Maso, Luigino, Kelsey, Karl, McClean, Michael, Vaughan, Thomas L, Lazarus, Philip, Purdue, Mark P, Hayes, Richard B, Chen, Chu, Schwartz, Stephen M, Shangina, Oxana, Koifman, Sergio, Ahrens, Wolfgang, Matos, Elena, Lagiou, Pagona, Lissowska, Jolanta, Szeszenia-Dabrowska, Neonila, Fernandez, Leticia, Menezes, Ana, Agudo, Antonio, Daudt, Alexander W, Richiardi, Lorenzo, Kjaerheim, Kristina, Mates, Dana, Betka, Jaroslav, Yu, Guo-Pei, Schantz, Stimson, Simonato, Lorenzo, Brenner, Hermann, Conway, David I, Macfarlane, Tatiana V, Thomson, Peter, Fabianova, Eleonora, Znaor, Ariana, Rudnai, Peter, Healy, Claire, Boffetta, Paolo, Chuang, Shu-Chun, Lee, Yuan-Chin Amy, Hashibe, Mia, and Boccia, Stefania

Subjects
Epidemiology, Public Health, Health Sciences, Tobacco, Tobacco Smoke and Health, Prevention, Rare Diseases, Clinical Research, Substance Misuse, Cancer, Digestive Diseases, Dental/Oral and Craniofacial Disease, Good Health and Well Being, Adult, Aged, Alcohol Drinking, Body Height, Case-Control Studies, Educational Status, Female, Head and Neck Neoplasms, Humans, Incidence, Interviews as Topic, Logistic Models, Male, Middle Aged, Odds Ratio, Overweight, Risk Factors, Smoking, Height, Consortium, Head and neck neoplasms, Public Health and Health Services
Abstract

Several epidemiological studies have shown a positive association between adult height and cancer incidence. The only study conducted among women on mouth and pharynx cancer risk, however, reported an inverse association. This study aims to investigate the association between height and the risk of head and neck cancer (HNC) within a large international consortium of HNC. We analyzed pooled individual-level data from 24 case-control studies participating in the International Head and Neck Cancer Epidemiology Consortium. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated separately for men and women for associations between height and HNC risk. Educational level, tobacco smoking, and alcohol consumption were included in all regression models. Stratified analyses by HNC subsites were performed. This project included 17,666 cases and 28,198 controls. We found an inverse association between height and HNC (adjusted OR per 10 cm height = 0.91, 95% CI 0.86-0.95 for men; adjusted OR = 0.86, 95% CI 0.79-0.93 for women). In men, the estimated OR did vary by educational level, smoking status, geographic area, and control source. No differences by subsites were detected. Adult height is inversely associated with HNC risk. As height can be considered a marker of childhood illness and low energy intake, the inverse association is consistent with prior studies showing that HNC occur more frequently among deprived individuals. Further studies designed to elucidate the mechanism of such association would be warranted.

Published
2014

9. Association of Marijuana Smoking with Oropharyngeal and Oral Tongue Cancers: Pooled Analysis from the INHANCE Consortium

Author

Marks, Morgan A, Chaturvedi, Anil K, Kelsey, Karl, Straif, Kurt, Berthiller, Julien, Schwartz, Stephen M, Smith, Elaine, Wyss, Annah, Brennan, Paul, Olshan, Andrew F, Wei, Qingyi, Sturgis, Erich M, Zhang, Zuo-Feng, Morgenstern, Hal, Muscat, Joshua, Lazarus, Philip, McClean, Michael, Chen, Chu, Vaughan, Thomas L, Wunsch-Filho, Victor, Curado, Maria Paula, Koifman, Sergio, Matos, Elena, Menezes, Ana, Daudt, Alexander W, Fernandez, Leticia, Posner, Marshall, Boffetta, Paolo, Lee, Yuan-Chin Amy, Hashibe, Mia, and D'Souza, Gypsyamber

Subjects
Epidemiology, Biomedical and Clinical Sciences, Health Sciences, Oncology and Carcinogenesis, Digestive Diseases, Dental/Oral and Craniofacial Disease, Infectious Diseases, Rare Diseases, Tobacco, Sexually Transmitted Infections, Cancer, Minority Health, Women's Health, Cannabinoid Research, Substance Misuse, Health Disparities, Tobacco Smoke and Health, Drug Abuse (NIDA only), Prevention, 2.2 Factors relating to the physical environment, 2.1 Biological and endogenous factors, Good Health and Well Being, Adult, Aged, Alcohol Drinking, Carcinoma, Squamous Cell, Case-Control Studies, Female, Head and Neck Neoplasms, Humans, Incidence, Latin America, Male, Marijuana Smoking, Middle Aged, Oropharyngeal Neoplasms, Risk Factors, Squamous Cell Carcinoma of Head and Neck, Tobacco Use, Tongue Neoplasms, United States, Medical and Health Sciences, Biomedical and clinical sciences, Health sciences
Abstract

BackgroundThe incidence of oropharyngeal and oral tongue cancers has increased over the last 20 years which parallels increased use of marijuana among individuals born after 1950.MethodsA pooled analysis was conducted comprising individual-level data from nine case-control studies from the United States and Latin America in the INHANCE consortium. Self-reported information on marijuana smoking, demographic, and behavioral factors was obtained from 1,921 oropharyngeal cases, 356 oral tongue cases, and 7,639 controls.ResultsCompared with never marijuana smokers, ever marijuana smokers had an elevated risk of oropharyngeal [adjusted OR (aOR), 1.24; 95% confidence interval (CI): 1.06-1.47] and a reduced risk of oral tongue cancer (aOR, 0.47; 95% CI, 0.29, 0.75). The risk of oropharyngeal cancer remained elevated among never tobacco and alcohol users. The risk of oral tongue cancer was reduced among never users of tobacco and alcohol. Sensitivity analysis adjusting for potential confounding by HPV exposure attenuated the association of marijuana use with oropharyngeal cancer (aOR, 0.99; 95% CI, 0.71-1.25), but had no effect on the oral tongue cancer association.ConclusionsThese results suggest that the association of marijuana use with head and neck carcinoma may differ by tumor site.ImpactThe associations of marijuana use with oropharyngeal and oral tongue cancer are consistent with both possible pro- and anticarcinogenic effects of cannabinoids. Additional work is needed to rule out various sources of bias, including residual confounding by HPV infection and misclassification of marijuana exposure.

Published
2014

10. Diet and the risk of head and neck cancer: a pooled analysis in the INHANCE consortium

Author

Chuang, Shu-Chun, Jenab, Mazda, Heck, Julia E, Bosetti, Cristina, Talamini, Renato, Matsuo, Keitaro, Castellsague, Xavier, Franceschi, Silvia, Herrero, Rolando, Winn, Deborah M, Vecchia, Carlo La, Morgenstern, Hal, Zhang, Zuo-Feng, Levi, Fabio, Maso, Luigino Dal, Kelsey, Karl, McClean, Michael D, Vaughan, Thomas, Lazarus, Philip, Muscat, Joshua, Ramroth, Heribert, Chen, Chu, Schwartz, Stephen M, Eluf-Neto, Jose, Hayes, Richard B, Purdue, Mark, Boccia, Stefania, Cadoni, Gabriella, Zaridze, David, Koifman, Sergio, Curado, Maria Paula, Ahrens, Wolfgang, Benhamou, Simone, Matos, Elena, Lagiou, Pagona, Szeszenia-Dabrowska, Neonilla, Olshan, Andrew F, Fernandez, Leticia, Menezes, Ana, Agudo, Antonio, Daudt, Alexander W, Merletti, Franco, Macfarlane, Gary J, Kjaerheim, Kristina, Mates, Dana, Holcatova, Ivana, Schantz, Stimson, Yu, Guo-Pei, Simonato, Lorenzo, Brenner, Hermann, Mueller, Heiko, Conway, David I, Thomson, Peter, Fabianova, Eleonora, Znaor, Ariana, Rudnai, Peter, Healy, Claire M, Ferro, Gilles, Brennan, Paul, Boffetta, Paolo, and Hashibe, Mia

Subjects
Public Health, Biomedical and Clinical Sciences, Nutrition and Dietetics, Health Sciences, Nutrition, Cancer, Prevention, Dental/Oral and Craniofacial Disease, Digestive Diseases, Rare Diseases, Oral and gastrointestinal, Adult, Aged, Case-Control Studies, Diet, Female, Head and Neck Neoplasms, Humans, Male, Middle Aged, Risk Factors, Head and neck cancer, Fruit and vegetable, Red meat, Processed meat, Oncology and Carcinogenesis, Public Health and Health Services, Epidemiology, Oncology and carcinogenesis
Abstract

We investigated the association between diet and head and neck cancer (HNC) risk using data from the International Head and Neck Cancer Epidemiology (INHANCE) consortium. The INHANCE pooled data included 22 case-control studies with 14,520 cases and 22,737 controls. Center-specific quartiles among the controls were used for food groups, and frequencies per week were used for single food items. A dietary pattern score combining high fruit and vegetable intake and low red meat intake was created. Odds ratios (OR) and 95% confidence intervals (CI) for the dietary items on the risk of HNC were estimated with a two-stage random-effects logistic regression model. An inverse association was observed for higher-frequency intake of fruit (4th vs. 1st quartile OR = 0.52, 95% CI = 0.43-0.62, p (trend) < 0.01) and vegetables (OR = 0.66, 95% CI = 0.49-0.90, p (trend) = 0.01). Intake of red meat (OR = 1.40, 95% CI = 1.13-1.74, p (trend) = 0.13) and processed meat (OR = 1.37, 95% CI = 1.14-1.65, p (trend) < 0.01) was positively associated with HNC risk. Higher dietary pattern scores, reflecting high fruit/vegetable and low red meat intake, were associated with reduced HNC risk (per score increment OR = 0.90, 95% CI = 0.84-0.97).

Published
2012

11. Sexual behaviours and the risk of head and neck cancers: a pooled analysis in the International Head and Neck Cancer Epidemiology (INHANCE) consortium

Author

Heck, Julia E, Berthiller, Julien, Vaccarella, Salvatore, Winn, Deborah M, Smith, Elaine M, Shan'gina, Oxana, Schwartz, Stephen M, Purdue, Mark P, Pilarska, Agnieszka, Eluf-Neto, Jose, Menezes, Ana, McClean, Michael D, Matos, Elena, Koifman, Sergio, Kelsey, Karl T, Herrero, Rolando, Hayes, Richard B, Franceschi, Silvia, Wünsch-Filho, Victor, Fernández, Leticia, Daudt, Alexander W, Curado, Maria Paula, Chen, Chu, Castellsagué, Xavier, Ferro, Gilles, Brennan, Paul, Boffetta, Paolo, and Hashibe, Mia

Subjects
Health Services and Systems, Health Sciences, Dental/Oral and Craniofacial Disease, Cancer, Sexually Transmitted Infections, Infectious Diseases, Digestive Diseases, Rare Diseases, Reproductive health and childbirth, Adult, Age Factors, Aged, Case-Control Studies, Confounding Factors, Epidemiologic, Female, Head and Neck Neoplasms, Health Behavior, Humans, Male, Middle Aged, Odds Ratio, Papillomavirus Infections, Sexual Behavior, Socioeconomic Factors, Sexual practices, head and neck cancer, oropharyngeal neoplasms, homosexual, gay men, risk factors, pooled analyses, Statistics, Public Health and Health Services, Epidemiology, Public health
Abstract

BackgroundSexual contact may be the means by which head and neck cancer patients are exposed to human papillomavirus (HPV).MethodsWe undertook a pooled analysis of four population-based and four hospital-based case-control studies from the International Head and Neck Cancer Epidemiology (INHANCE) consortium, with participants from Argentina, Australia, Brazil, Canada, Cuba, India, Italy, Spain, Poland, Puerto Rico, Russia and the USA. The study included 5642 head and neck cancer cases and 6069 controls. We calculated odds ratios (ORs) of associations between cancer and specific sexual behaviours, including practice of oral sex, number of lifetime sexual partners and oral sex partners, age at sexual debut, a history of same-sex contact and a history of oral-anal contact. Findings were stratified by sex and disease subsite.ResultsCancer of the oropharynx was associated with having a history of six or more lifetime sexual partners [OR = 1.25, 95% confidence interval (CI) 1.01, 1.54] and four or more lifetime oral sex partners (OR = 2.25, 95% CI 1.42, 3.58). Cancer of the tonsil was associated with four or more lifetime oral sex partners (OR = 3.36, 95 % CI 1.32, 8.53), and, among men, with ever having oral sex (OR = 1.59, 95% CI 1.09, 2.33) and with an earlier age at sexual debut (OR = 2.36, 95% CI 1.37, 5.05). Cancer of the base of the tongue was associated with ever having oral sex among women (OR = 4.32, 95% CI 1.06, 17.6), having two sexual partners in comparison with only one (OR = 2.02, 95% CI 1.19, 3.46) and, among men, with a history of same-sex sexual contact (OR = 8.89, 95% CI 2.14, 36.8).ConclusionsSexual behaviours are associated with cancer risk at the head and neck cancer subsites that have previously been associated with HPV infection.

Published
2010

12. Laryngeal Cancer Risks in Workers Exposed to Lung Carcinogens: Exposure–Effect Analyses Using a Quantitative Job Exposure Matrix

Author

Hall, Amy L., Kromhout, Hans, Schüz, Joachim, Peters, Susan, Portengen, Lützen, Vermeulen, Roel, Agudo, Antonio, Ahrens, Wolfgang, Boffetta, Paolo, Brennan, Paul, Canova, Cristina, Conway, David I., Curado, Maria Paula, Daudt, Alexander W., Fernandez, Leticia, Hashibe, Mia, Healy, Claire M., Holcatova, Ivana, Kjaerheim, Kristina, Koifman, Rosalina, Lagiou, Pagona, Luce, Danièle, Macfarlane, Gary J., Menezes, Ana, Menvielle, Gwenn, Polesel, Jerry, Ramroth, Heribert, Richiardi, Lorenzo, Stücker, Isabelle, Thomson, Peter, Vilensky, Marta, Wunsch-Filho, Victor, Yuan-Chin, Amy Lee, Znaor, Ariana, Straif, Kurt, and Olsson, Ann

Published
2020
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13. Supplementary Table S6 from Association of Marijuana Smoking with Oropharyngeal and Oral Tongue Cancers: Pooled Analysis from the INHANCE Consortium

Author

Marks, Morgan A., primary, Chaturvedi, Anil K., primary, Kelsey, Karl, primary, Straif, Kurt, primary, Berthiller, Julien, primary, Schwartz, Stephen M., primary, Smith, Elaine, primary, Wyss, Annah, primary, Brennan, Paul, primary, Olshan, Andrew F., primary, Wei, Qingyi, primary, Sturgis, Erich M., primary, Zhang, Zuo-Feng, primary, Morgenstern, Hal, primary, Muscat, Joshua, primary, Lazarus, Philip, primary, McClean, Michael, primary, Chen, Chu, primary, Vaughan, Thomas L., primary, Wunsch-Filho, Victor, primary, Curado, Maria Paula, primary, Koifman, Sergio, primary, Matos, Elena, primary, Menezes, Ana, primary, Daudt, Alexander W., primary, Fernandez, Leticia, primary, Posner, Marshall, primary, Boffetta, Paolo, primary, Lee, Yuan-Chin Amy, primary, Hashibe, Mia, primary, and D'Souza, Gypsyamber, primary

Published
2023
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14. Statistical Appendix from Association of Marijuana Smoking with Oropharyngeal and Oral Tongue Cancers: Pooled Analysis from the INHANCE Consortium

Author

Marks, Morgan A., primary, Chaturvedi, Anil K., primary, Kelsey, Karl, primary, Straif, Kurt, primary, Berthiller, Julien, primary, Schwartz, Stephen M., primary, Smith, Elaine, primary, Wyss, Annah, primary, Brennan, Paul, primary, Olshan, Andrew F., primary, Wei, Qingyi, primary, Sturgis, Erich M., primary, Zhang, Zuo-Feng, primary, Morgenstern, Hal, primary, Muscat, Joshua, primary, Lazarus, Philip, primary, McClean, Michael, primary, Chen, Chu, primary, Vaughan, Thomas L., primary, Wunsch-Filho, Victor, primary, Curado, Maria Paula, primary, Koifman, Sergio, primary, Matos, Elena, primary, Menezes, Ana, primary, Daudt, Alexander W., primary, Fernandez, Leticia, primary, Posner, Marshall, primary, Boffetta, Paolo, primary, Lee, Yuan-Chin Amy, primary, Hashibe, Mia, primary, and D'Souza, Gypsyamber, primary

Published
2023
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15. An examination of male and female odds ratios by BMI, cigarette smoking, and alcohol consumption for cancers of the oral cavity, pharynx, and larynx in pooled data from 15 case-control studies

Author

Lubin, Jay H., Muscat, Joshua, Gaudet, Mia M., Olshan, Andrew F., Curado, Maria Paula, Maso, Luigino Dal, Wünsch-Filho, Victor, Sturgis, Erich M., Szeszenia-Dabrowska, Neonilia, Castellsague, Xavier, Zhang, Zuo-Feng, Smith, Elaine, Fernandez, Leticia, Matos, Elena, Franceschi, Silvia, Fabianova, Eleonora, Rudnai, Peter, Purdue, Mark P., Mates, Dana, Wei, Qingyi, Herrero, Rolando, Kelsey, Karl, Morgenstern, Hal, Shangina, Oxana, Koifman, Sergio, Lissowska, Jolanta, Levi, Fabio, Daudt, Alexander W., Neto, Jose Eluf, Chen, Chu, Lazarus, Philip, Winn, Deborah M., Schwartz, Stephen M., Boffetta, Paolo, Brennan, Paul, Menezes, Ana, La Vecchia, Carlo, McClean, Michael, Talamini, Renato, Rajkumar, Thangarajan, Hayes, Richard B., and Hashibe, Mia

Published
2011

16. Lessons learned from the INHANCE consortium: An overview of recent results on head and neck cancer

Author

Bravi, Francesca, Lee, Yuan‐Chin Amy, Hashibe, Mia, Boffetta, Paolo, Conway, David I., Ferraroni, Monica, La Vecchia, Carlo, Edefonti, Valeria, Agudo, Antonio, Ahrens, Wolfgang, Benhamou, Simone, Boccia, Stefania, Brennan, Paul, Brenner, Hermann, Cadoni, Gabriella, Canova, Cristina, Chen, Chu, Chuang, Shu‐Chun, Curado, Maria Paula, Dal Maso, Luigino, Daudt, Alexander W., D'Souza, Gypsyamber, Fabianova, Eleonora, Fernandez, Leticia, Franceschi, Silvia, Garavello, Werner, Gillison, Maura, Gross, Neil D., Hayes, Richard B., Healy, Claire, Herrero, Rolando, Holcatova, Ivana, Kelsey, Karl, Kjaerheim, Kristina, Koifman, Rosalina, Lagiou, Pagona, Lazarus, Philip, Levi, Fabio, Li, Guojun, Lissowska, Jolanta, Luce, Daniele, Macfarlane, Gary J., Mates, Dana, Matsuo, Keitaro, McClean, Michael, Menezes, Ana, Menvielle, Gwenn, Morgenstern, Hal, Moyses, Raquel A., Moysich, Kirsten, Muscat, Joshua, Negri, Eva, Olshan, Andrew F., Pandics, Tamas, Polesel, Jerry, Purdue, Mark P., Radoï, Loredana, Ramroth, Heribert, Richiardi, Lorenzo, Schantz, Stimson, Schwartz, Stephen M., Serraino, Diego, Shangina, Oxana, Smith, Elaine, Sturgis, Erich M., Świątkowska, Beata, Thomson, Peter, Toporcov, Tatiana N., Vaughan, Thomas L., Vilensky, Marta, Winn, Deborah M., Wunsch‐Filho, Victor, Yu, Guo‐Pei, Zevallos, Jose P, Zhang, Zuo‐Feng, Zheng, Tongzhang, Znaor, Ariana, Bravi, F, Lee, Y, Hashibe, M, Boffetta, P, Conway, D, Ferraroni, M, La Vecchia, C, Edefonti, V, Agudo, A, Ahrens, W, Benhamou, S, Boccia, S, Brennan, P, Brenner, H, Cadoni, G, Canova, C, Chen, C, Chuang, S, Curado, M, Dal Maso, L, Daudt, A, D'Souza, G, Fabianova, E, Fernandez, L, Franceschi, S, Garavello, W, Gillison, M, Gross, N, Hayes, R, Healy, C, Herrero, R, Holcatova, I, Kelsey, K, Kjaerheim, K, Koifman, R, Lagiou, P, Lazarus, P, Levi, F, Li, G, Lissowska, J, Luce, D, Macfarlane, G, Mates, D, Matsuo, K, Mcclean, M, Menezes, A, Menvielle, G, Morgenstern, H, Moyses, R, Moysich, K, Muscat, J, Negri, E, Olshan, A, Pandics, T, Polesel, J, Purdue, M, Radoi, L, Ramroth, H, Richiardi, L, Schantz, S, Schwartz, S, Serraino, D, Shangina, O, Smith, E, Sturgis, E, Swiatkowska, B, Thomson, P, Toporcov, T, Vaughan, T, Vilensky, M, Winn, D, Wunsch-Filho, V, Yu, G, Zevallos, J, Zhang, Z, Zheng, T, Znaor, A, Bravi F., Lee Y.-C.A., Hashibe M., Boffetta P., Conway D.I., Ferraroni M., La Vecchia C., Edefonti V., Agudo A., Ahrens W., Benhamou S., Boccia S., Brennan P., Brenner H., Cadoni G., Canova C., Chen C., Chuang S.-C., Curado M.P., Dal Maso L., Daudt A.W., D'Souza G., Fabianova E., Fernandez L., Franceschi S., Garavello W., Gillison M., Gross N.D., Hayes R.B., Healy C., Herrero R., Holcatova I., Kelsey K., Kjaerheim K., Koifman R., Lagiou P., Lazarus P., Levi F., Li G., Lissowska J., Luce D., Macfarlane G.J., Mates D., Matsuo K., McClean M., Menezes A., Menvielle G., Morgenstern H., Moyses R.A., Moysich K., Muscat J., Negri E., Olshan A.F., Pandics T., Polesel J., Purdue M.P., Radoi L., Ramroth H., Richiardi L., Schantz S., Schwartz S.M., Serraino D., Shangina O., Smith E., Sturgis E.M., Swiatkowska B., Thomson P., Toporcov T.N., Vaughan T.L., Vilensky M., Winn D.M., Wunsch-Filho V., Yu G.-P., Zevallos J.P., Zhang Z.-F., Zheng T., and Znaor A.

Subjects
INHANCE, medicine.medical_specialty, Oral health, Cancer recurrence, Article, Tobacco Use, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Epidemiology, medicine, Humans, pooled analysi, prognostic factor, General Dentistry, Beneficial effects, Head and Neck Neoplasm, business.industry, Incidence (epidemiology), Head and neck cancer, oral cavity cancer, Case-control study, prognostic factors, 030206 dentistry, medicine.disease, risk factor, Otorhinolaryngology, Head and Neck Neoplasms, Case-Control Studies, 030220 oncology & carcinogenesis, Family medicine, Etiology, laryngeal cancer, head and neck cancer, Settore MED/31 - OTORINOLARINGOIATRIA, pooled analysis, Neoplasm Recurrence, Local, Case-Control Studie, business, Human
Abstract

Objective:\ud \ud To summarize the latest evidence on head and neck cancer epidemiology from the International Head and Neck Cancer Epidemiology (INHANCE) consortium.\ud \ud Subjects and Methods:\ud \ud INHANCE was established in 2004 to elucidate the etiology of head and neck cancer through pooled analyses of individual‐level data on a large scale. We summarize results from recent INHANCE‐based publications updating our 2015 overview.\ud \ud Results:\ud \ud Seventeen papers were published between 2015 and May 2020. These studies further define the nature of risks associated with tobacco and alcohol, and occupational exposures on head and neck cancer. The beneficial effects on incidence of head and neck cancer were identified for good oral health, endogenous and exogenous hormonal factors, and selected aspects of diet related to fruit and vegetables. INHANCE has begun to develop risk prediction models and to pool follow‐up data on their studies, finding that ~30% of cases had cancer recurrence and 9% second primary cancers, with overall‐ and disease‐specific 5‐year‐survival of 51% and 57%, respectively.\ud \ud Conclusions:\ud \ud The number and importance of INHANCE scientific findings provides further evidence of the advantages of large‐scale internationally collaborative projects and will support the development of prevention strategies.

Published
2020
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17. Risk factors for head and neck cancer in more and less developed countries: Analysis from the INHANCE Consortium

Author

Goyal, Neerav, Hennessy, Max, Lehman, Erik, Lin, Wenxue, Agudo, Antonio, Ahrens, Wolfgang, Boccia, Stefania, Brennan, Paul, Brenner, Hermann, Cadoni, Gabriella, Canova, Cristina, Chen, Chu, Conway, David, Curado, Maria Paula, Dal Maso, Luigino, Daudt, Alexander W, Edefonti, Valeria, Fabianova, Eleonora, Fernandez, Leticia, Franceschi, Silvia, Garavello, Werner, Gillison, Maura, Hayes, Richard B, Healy, Claire, Herrero, Rolando, Holcatova, Ivana, Kanda, Jossy L, Kelsey, Karl, Hansen, Bo T, Koifman, Rosalina, Lagiou, Pagona, La Vecchia, Carlo, Levi, Fabio, Li, Guojun, Lissowska, Jolanta, Mendoza López, Rossana, Luce, Danièle, Macfarlane, Gary, Mates, Dana, Matsuo, Keitaro, Mcclean, Michael, Menezes, Ana, Menvielle, Gwenn, Morgenstern, Hal, Moysich, Kirsten, Negri, Eva, Olshan, Andrew F, Pandics, Tama, Polesel, Jerry, Purdue, Mark, Radoi, Loredana, Ramroth, Heribert, Richiardi, Lorenzo, Schantz, Stimson, Schwartz, Stephen M, Serraino, Diego, Shangina, Oxana, Smith, Elaine, Sturgis, Erich M, Świątkowska, Beata, Thomson, Peter, Vaughan, Thomas L, Vilensky, Marta, Winn, Deborah M, Wunsch-Filho, Victor, Yu, Guo-Pei, Zevallos, Jose P, Zhang, Zuo-Feng, Zheng, Tongzhang, Znaor, Ariana, Boffetta, Paolo, Hashibe, Mia, Lee, Yuan-Chin Amy, Muscat, Joshua E, Boccia, Stefania (ORCID:0000-0002-1864-749X), Cadoni, Gabriella (ORCID:0000-0001-8244-784X), Goyal, Neerav, Hennessy, Max, Lehman, Erik, Lin, Wenxue, Agudo, Antonio, Ahrens, Wolfgang, Boccia, Stefania, Brennan, Paul, Brenner, Hermann, Cadoni, Gabriella, Canova, Cristina, Chen, Chu, Conway, David, Curado, Maria Paula, Dal Maso, Luigino, Daudt, Alexander W, Edefonti, Valeria, Fabianova, Eleonora, Fernandez, Leticia, Franceschi, Silvia, Garavello, Werner, Gillison, Maura, Hayes, Richard B, Healy, Claire, Herrero, Rolando, Holcatova, Ivana, Kanda, Jossy L, Kelsey, Karl, Hansen, Bo T, Koifman, Rosalina, Lagiou, Pagona, La Vecchia, Carlo, Levi, Fabio, Li, Guojun, Lissowska, Jolanta, Mendoza López, Rossana, Luce, Danièle, Macfarlane, Gary, Mates, Dana, Matsuo, Keitaro, Mcclean, Michael, Menezes, Ana, Menvielle, Gwenn, Morgenstern, Hal, Moysich, Kirsten, Negri, Eva, Olshan, Andrew F, Pandics, Tama, Polesel, Jerry, Purdue, Mark, Radoi, Loredana, Ramroth, Heribert, Richiardi, Lorenzo, Schantz, Stimson, Schwartz, Stephen M, Serraino, Diego, Shangina, Oxana, Smith, Elaine, Sturgis, Erich M, Świątkowska, Beata, Thomson, Peter, Vaughan, Thomas L, Vilensky, Marta, Winn, Deborah M, Wunsch-Filho, Victor, Yu, Guo-Pei, Zevallos, Jose P, Zhang, Zuo-Feng, Zheng, Tongzhang, Znaor, Ariana, Boffetta, Paolo, Hashibe, Mia, Lee, Yuan-Chin Amy, Muscat, Joshua E, Boccia, Stefania (ORCID:0000-0002-1864-749X), and Cadoni, Gabriella (ORCID:0000-0001-8244-784X)

Abstract

Objective: We analyzed the pooled case-control data from the International Head and Neck Cancer Epidemiology (INHANCE) consortium to compare cigarette smoking and alcohol consumption risk factors for head and neck cancer between less developed and more developed countries. Subjects and methods: The location of each study was categorized as either a less developed or more developed country. We compared the risk of overall head and neck cancer and cancer of specific anatomic subsites associated with cigarette smoking and alcohol consumption. Additionally, age and sex distribution between categories was compared. Results: The odds ratios for head and neck cancer sites associated with smoking duration differed between less developed and more developed countries. Smoking greater than 20 years conferred a higher risk for oral cavity and laryngeal cancer in more developed countries, whereas the risk was greater for oropharynx and hypopharynx cancer in less developed countries. Alcohol consumed for more than 20 years conferred a higher risk for oropharynx, hypopharynx and larynx cancer in less developed countries. The proportion of cases that were young (<45 years) or female differed by country type for some HNC subsites. Conclusion: These findings suggest the degree of industrialization and economic development affects the relationship between smoking-and alcohol with head and neck cancer.

Published
2022

18. Risk factors for head and neck cancer in more and less developed countries: Analysis from the INHANCE consortium

Author

Goyal, Neerav, primary, Hennessy, Max, additional, Lehman, Erik, additional, Lin, Wenxue, additional, Agudo, Antonio, additional, Ahrens, Wolfgang, additional, Boccia, Stefania, additional, Brennan, Paul, additional, Brenner, Hermann, additional, Cadoni, Gabriella, additional, Canova, Cristina, additional, Chen, Chu, additional, Conway, David, additional, Curado, Maria Paula, additional, Dal Maso, Luigino, additional, Daudt, Alexander W., additional, Edefonti, Valeria, additional, Fabianova, Eleonora, additional, Fernandez, Leticia, additional, Franceschi, Silvia, additional, Garavello, Werner, additional, Gillison, Maura, additional, Hayes, Richard B., additional, Healy, Claire, additional, Herrero, Rolando, additional, Holcatova, Ivana, additional, Kanda, Jossy L., additional, Kelsey, Karl, additional, Hansen, Bo T., additional, Koifman, Rosalina, additional, Lagiou, Pagona, additional, La Vecchia, Carlo, additional, Levi, Fabio, additional, Li, Guojun, additional, Lissowska, Jolanta, additional, Mendoza López, Rossana, additional, Luce, Danièle, additional, Macfarlane, Gary, additional, Mates, Dana, additional, Matsuo, Keitaro, additional, McClean, Michael, additional, Menezes, Ana, additional, Menvielle, Gwenn, additional, Morgenstern, Hal, additional, Moysich, Kirsten, additional, Negri, Eva, additional, Olshan, Andrew F., additional, Pandics, Tamas, additional, Polesel, Jerry, additional, Purdue, Mark, additional, Radoi, Loredana, additional, Ramroth, Heribert, additional, Richiardi, Lorenzo, additional, Schantz, Stimson, additional, Schwartz, Stephen M., additional, Serraino, Diego, additional, Shangina, Oxana, additional, Smith, Elaine, additional, Sturgis, Erich M., additional, Świątkowska, Beata, additional, Thomson, Peter, additional, Vaughan, Thomas L., additional, Vilensky, Marta, additional, Winn, Deborah M., additional, Wunsch‐Filho, Victor, additional, Yu, Guo‐Pei, additional, Zevallos, Jose P., additional, Zhang, Zuo‐Feng, additional, Zheng, Tongzhang, additional, Znaor, Ariana, additional, Boffetta, Paolo, additional, Hashibe, Mia, additional, Lee, Yuan‐Chin A., additional, and Muscat, Joshua E., additional

Published
2022
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19. Risk factors for head and neck cancer in more and less developed countries: Analysis from the INHANCE consortium.

Author

Goyal, Neerav, Hennessy, Max, Lehman, Erik, Lin, Wenxue, Agudo, Antonio, Ahrens, Wolfgang, Boccia, Stefania, Brennan, Paul, Brenner, Hermann, Cadoni, Gabriella, Canova, Cristina, Chen, Chu, Conway, David, Curado, Maria Paula, Dal Maso, Luigino, Daudt, Alexander W., Edefonti, Valeria, Fabianova, Eleonora, Fernandez, Leticia, and Franceschi, Silvia

Subjects
DEVELOPED countries, CONFIDENCE intervals, MOUTH tumors, AGE distribution, HEAD & neck cancer, LARYNGEAL tumors, OROPHARYNGEAL cancer, RISK assessment, SEX distribution, ALCOHOL drinking, RESEARCH funding, SOCIAL classes, DESCRIPTIVE statistics, DISEASE prevalence, SMOKING, ODDS ratio, LOGISTIC regression analysis, STATISTICAL models, DATA analysis software, HYPOPHARYNGEAL cancer, DISEASE risk factors
Abstract

Objective: We analyzed the pooled case‐control data from the International Head and Neck Cancer Epidemiology (INHANCE) consortium to compare cigarette smoking and alcohol consumption risk factors for head and neck cancer between less developed and more developed countries. Subjects and Methods: The location of each study was categorized as either a less developed or more developed country. We compared the risk of overall head and neck cancer and cancer of specific anatomic subsites associated with cigarette smoking and alcohol consumption. Additionally, age and sex distribution between categories was compared. Results: The odds ratios for head and neck cancer sites associated with smoking duration differed between less developed and more developed countries. Smoking greater than 20 years conferred a higher risk for oral cavity and laryngeal cancer in more developed countries, whereas the risk was greater for oropharynx and hypopharynx cancer in less developed countries. Alcohol consumed for more than 20 years conferred a higher risk for oropharynx, hypopharynx, and larynx cancer in less developed countries. The proportion of cases that were young (<45 years) or female differed by country type for some HNC subsites. Conclusion: These findings suggest the degree of industrialization and economic development affects the relationship between smoking and alcohol with head and neck cancer. [ABSTRACT FROM AUTHOR]

Published
2023
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20. Cigarette, Cigar, and Pipe Smoking and the Risk of Head and Neck Cancers: Pooled Analysis in the International Head and Neck Cancer Epidemiology Consortium

Author

Wyss, Annah, Hashibe, Mia, Chuang, Shu-Chun, Lee, Yuan-Chin Amy, Zhang, Zuo-Feng, Yu, Guo-Pei, Winn, Deborah M., Wei, Qingyi, Talamini, Renato, Szeszenia-Dabrowska, Neonila, Sturgis, Erich M., Smith, Elaine, Shangina, Oxana, Schwartz, Stephen M., Schantz, Stimson, Rudnai, Peter, Purdue, Mark P., Eluf-Neto, Jose, Muscat, Joshua, Morgenstern, Hal, Michaluart, Pedro, Jr, Menezes, Ana, Matos, Elena, Mates, Ioan Nicolae, Lissowska, Jolanta, Levi, Fabio, Lazarus, Philip, La Vecchia, Carlo, Koifman, Sergio, Herrero, Rolando, Hayes, Richard B., Franceschi, Silvia, Wünsch-Filho, Victor, Fernandez, Leticia, Fabianova, Eleonora, Daudt, Alexander W., Dal Maso, Luigino, Curado, Maria Paula, Chen, Chu, Castellsague, Xavier, de Carvalho, Marcos Brasilino, Cadoni, Gabriella, Boccia, Stefania, Brennan, Paul, Boffetta, Paolo, and Olshan, Andrew F.

Published
2013
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21. Vitamin or mineral supplement intake and the risk of head and neck cancer: pooled analysis in the INHANCE consortium

Author

Li, Qian, Chuang, Shu-Chun, Eluf-Neto, Jose, Menezes, Ana, Matos, Elena, Koifman, Sergio, Wünsch-Filho, Victor, Fernandez, Leticia, Daudt, Alexander W., Curado, Maria Paula, Winn, Deborah M., Franceschi, Silvia, Herrero, Rolando, Castellsague, Xavier, Morgenstern, Hal, Zhang, Zuo-Feng, Lazarus, Philip, Muscat, Joshua, McClean, Michael, Kelsey, Karl T., Hayes, Richard B., Purdue, Mark P., Schwartz, Stephen M., Chen, Chu, Benhamou, Simone, Olshan, Andrew F., Yu, Guopei, Schantz, Stimson, Ferro, Gilles, Brennan, Paul, Boffetta, Paolo, and Hashibe, Mia

Published
2012
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22. Body mass index and risk of head and neck cancer in a pooled analysis of case–control studies in the International Head and Neck Cancer Epidemiology (INHANCE) Consortium

Author

Gaudet, Mia M, Olshan, Andrew F, Chuang, Shu-Chun, Berthiller, Julien, Zhang, Zuo-Feng, Lissowska, Jolanta, Zaridze, David, Winn, Deborah M, Wei, Qingyi, Talamini, Renato, Szeszenia-Dabrowska, Neolilia, Sturgis, Erich M, Schwartz, Stephen M, Rudnai, Peter, Eluf-Neto, Jose, Muscat, Joshua, Morgenstern, Hal, Menezes, Ana, Matos, Elena, Bucur, Alexandru, Levi, Fabio, Lazarus, Philip, La Vecchia, Carlo, Koifman, Sergio, Kelsey, Karl, Herrero, Rolando, Hayes, Richard B, Franceschi, Silva, Wunsch-Filho, Victor, Fernandez, Leticia, Fabianova, Eleonora, Daudt, Alexander W, Dal Maso, Luigino, Paula Curado, Maria, Chen, Chu, Castellsague, Xavier, Benhamou, Simone, Boffetta, Paolo, Brennan, Paul, and Hashibe, Mia

Published
2010
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23. Body Mass Index, Cigarette Smoking, and Alcohol Consumption and Cancers of the Oral Cavity, Pharynx, and Larynx: Modeling Odds Ratios in Pooled Case-Control Data

Author

Lubin, Jay H., Gaudet, Mia M., Olshan, Andrew F., Kelsey, Karl, Boffetta, Paolo, Brennan, Paul, Castellsague, Xavier, Chen, Chu, Curado, Maria Paula, Maso, Luigino Dal, Daudt, Alexander W., Fabianova, Eleonora, Fernandez, Leticia, Wünsch-Filho, Victor, Franceschi, Silvia, Herrero, Rolando, Koifman, Sergio, La Vecchia, Carlo, Lazarus, Philip, Levi, Fabio, Lissowska, Jolanta, Mates, Ioan Nicolae, Matos, Elena, McClean, Michael, Menezes, Ana, Morgenstern, Hal, Muscat, Joshua, Neto, Jose Eluf, Purdue, Mark P., Rudnai, Peter, Schwartz, Stephen M., Shangina, Oxana, Sturgis, Erich M., Szeszenia-Dabrowska, Neonilia, Talamini, Renato, Wei, Qingyi, Winn, Deborah, Zhang, Zuo-Feng, Hashibe, Mia, and Hayes, Richard B.

Published
2010
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24. Cessation of alcohol drinking, tobacco smoking and the reversal of head and neck cancer risk

Author

Marron, Manuela, Boffetta, Paolo, Zhang, Zuo-Feng, Zaridze, David, Wünsch-Filho, Victor, Winn, Deborah M, Wei, Qingyi, Talamini, Renato, Szeszenia-Dabrowska, Neonila, Sturgis, Erich M, Smith, Elaine, Schwartz, Stephen M, Rudnai, Peter, Purdue, Mark P, Olshan, Andrew F, Eluf-Neto, Jose, Muscat, Joshua, Morgenstern, Hal, Menezes, Ana, McClean, Michael, Matos, Elena, Mates, Ioan Nicolae, Lissowska, Jolanta, Levi, Fabio, Lazarus, Philip, Vecchia, Carlo La, Koifman, Sergio, Kelsey, Karl, Herrero, Rolando, Hayes, Richard B, Franceschi, Silvia, Fernandez, Leticia, Fabianova, Eleonora, Daudt, Alexander W, Maso, Luigino Dal, Curado, Maria Paula, Cadoni, Gabriella, Chen, Chu, Castellsague, Xavier, Boccia, Stefania, Benhamou, Simone, Ferro, Gilles, Berthiller, Julien, Brennan, Paul, Møller, Henrik, and Hashibe, Mia

Published
2010

25. Total Exposure and Exposure Rate Effects for Alcohol and Smoking and Risk of Head and Neck Cancer: A Pooled Analysis of Case-Control Studies

Author

Lubin, Jay H., Purdue, Mark, Kelsey, Karl, Zhang, Zuo-Feng, Winn, Debbie, Wei, Qingyi, Talamini, Renato, Szeszenia-Dabrowska, Neonilia, Sturgis, Erich M., Smith, Elaine, Shangina, Oxana, Schwartz, Stephen M., Rudnai, Peter, Neto, Jose Eluf, Muscat, Joshua, Morgenstern, Hal, Menezes, Ana, Matos, Elena, Mates, Ioan Nicolae, Lissowska, Jolanta, Levi, Fabio, Lazarus, Philip, Vecchia, Carlo La, Koifman, Sergio, Herrero, Rolando, Franceschi, Silvia, Wünsch-Filho, Victor, Fernandez, Leticia, Fabianova, Eleonora, Daudt, Alexander W., Maso, Luigino Dal, Curado, Maria Paula, Chen, Chu, Castellsague, Xavier, Brennan, Paul, Boffetta, Paolo, Hashibe, Mia, and Hayes, Richard B.

Published
2009

26. Family history of cancer: Pooled analysis in the International Head and Neck Cancer Epidemiology Consortium

Author

Negri, Eva, Boffetta, Paolo, Berthiller, Julien, Castellsague, Xavier, Curado, Maria Paula, Maso, Luigino Dal, Daudt, Alexander W., Fabianova, Eleonora, Fernandez, Leticia, Wünsch-Filho, Victor, Franceschi, Silvia, Hayes, Richard B., Herrero, Rolando, Koifman, Sergio, Lazarus, Philip, Lence, Juan J., Levi, Fabio, Mates, Dana, Matos, Elena, Menezes, Ana, Muscat, Joshua, Eluf-Neto, Jose, Olshan, Andrew F., Rudnai, Peter, Shangina, Oxana, Sturgis, Erich M., Szeszenia-Dabrowska, Neonilia, Talamini, Renato, Wei, Qingyi, Winn, Deborah M., Zaridze, David, Lissowska, Jolanta, Zhang, Zuo-Feng, Ferro, Gilles, Brennan, Paul, La Vecchia, Carlo, and Hashibe, Mia

Published
2009
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27. Type of Alcoholic Beverage and Risk of Head and Neck Cancer—A Pooled Analysis Within the INHANCE Consortium

Author

Purdue, Mark P., Hashibe, Mia, Berthiller, Julien, La Vecchia, Carlo, Maso, Luigino Dal, Herrero, Rolando, Franceschi, Silvia, Castellsague, Xavier, Wei, Qingyi, Sturgis, Erich M., Morgenstern, Hal, Zhang, Zuo-Feng, Levi, Fabio, Talamini, Renato, Smith, Elaine, Muscat, Joshua, Lazarus, Philip, Schwartz, Stephen M., Chen, Chu, Neto, Jose Eluf, Wünsch-Filho, Victor, Zaridze, David, Koifman, Sergio, Curado, Maria Paula, Benhamou, Simone, Matos, Elena, Szeszenia-Dabrowska, Neonilia, Olshan, Andrew F., Lence, Juan, Menezes, Ana, Daudt, Alexander W., Mates, Ioan Nicolae, Pilarska, Agnieszka, Fabianova, Eleonora, Rudnai, Peter, Winn, Debbie, Ferro, Gilles, Brennan, Paul, Boffetta, Paolo, and Hayes, Richard B.

Published
2009

29. Alcohol Drinking in Never Users of Tobacco, Cigarette Smoking in Never Drinkers, and the Risk of Head and Neck Cancer: Pooled Analysis in the International Head and Neck Cancer Epidemiology Consortium

Author

Hashibe, Mia, Brennan, Paul, Benhamou, Simone, Castellsague, Xavier, Chen, Chu, Curado, Maria Paula, Maso, Luigino Dal, Daudt, Alexander W., Fabianova, Eleonora, Wünsch-Filho, Victor, Franceschi, Silvia, Hayes, Richard B., Herrero, Rolando, Koifman, Sergio, La Vecchia, Carlo, Lazarus, Philip, Levi, Fabio, Mates, Dana, Matos, Elena, Menezes, Ana, Muscat, Joshua, Eluf-Neto, Jose, Olshan, Andrew F., Rudnai, Peter, Schwartz, Stephen M., Smith, Elaine, Sturgis, Erich M., Szeszenia-Dabrowska, Neonilia, Talamini, Renato, Wei, Qingyi, Winn, Deborah M., Zaridze, David, Zatonski, Witold, Zhang, Zuo-Feng, Berthiller, Julien, and Boffetta, Paolo

Published
2007

30. Laryngeal Cancer Risks in Workers Exposed to Lung Carcinogens: Exposure-Effect Analyses Using a Quantitative Job Exposure Matrix

Author

Hall, Amy L, Kromhout, Hans, Schüz, Joachim, Peters, Susan, Portengen, Lützen, Vermeulen, Roel, Agudo, Antonio, Ahrens, Wolfgang, Boffetta, Paolo, Brennan, Paul, Canova, Cristina, Conway, David I, Curado, Maria Paula, Daudt, Alexander W, Fernandez, Leticia, Hashibe, Mia, Healy, Claire M, Holcatova, Ivana, Kjaerheim, Kristina, Koifman, Rosalina, Lagiou, Pagona, Luce, Danièle, Macfarlane, Gary J, Menezes, Ana, Menvielle, Gwenn, Polesel, Jerry, Ramroth, Heribert, Richiardi, Lorenzo, Stücker, Isabelle, Thomson, Peter, Vilensky, Marta, Wunsch-Filho, Victor, Lee, Yuan-Chin Amy, Znaor, Ariana, Straif, Kurt, Olsson, Ann, Hall, Amy L, Kromhout, Hans, Schüz, Joachim, Peters, Susan, Portengen, Lützen, Vermeulen, Roel, Agudo, Antonio, Ahrens, Wolfgang, Boffetta, Paolo, Brennan, Paul, Canova, Cristina, Conway, David I, Curado, Maria Paula, Daudt, Alexander W, Fernandez, Leticia, Hashibe, Mia, Healy, Claire M, Holcatova, Ivana, Kjaerheim, Kristina, Koifman, Rosalina, Lagiou, Pagona, Luce, Danièle, Macfarlane, Gary J, Menezes, Ana, Menvielle, Gwenn, Polesel, Jerry, Ramroth, Heribert, Richiardi, Lorenzo, Stücker, Isabelle, Thomson, Peter, Vilensky, Marta, Wunsch-Filho, Victor, Lee, Yuan-Chin Amy, Znaor, Ariana, Straif, Kurt, and Olsson, Ann

Abstract

INTRODUCTION: Various established occupational lung carcinogens are also suspected risk factors for laryngeal cancer. However, individual studies are often inadequate in size to investigate this relatively rare outcome. Other limitations include imprecise exposure assessment and inadequate adjustment for confounders.METHODS: This study applied a quantitative job exposure matrix (SYN-JEM) for four established occupational lung carcinogens to five case-control studies within the INHANCE Consortium. We used occupational histories for 2256 laryngeal cancer cases and 7857 controls recruited from 1989-2007. We assigned quantitative exposure levels for asbestos, respirable crystalline silica, chromium-VI, and chromium-VI & nickel combined (to address highly correlated exposures) via SYN-JEM. We assessed effects of occupational exposure on cancer risk for males (asbestos, respirable crystalline silica, chromium-VI, chromium-VI & nickel) and females (asbestos, respirable crystalline silica), adjusting for age, study, tobacco smoking, alcohol consumption, and asbestos exposure where relevant.RESULTS: Among females, odds ratios (ORs) were increased for ever versus never exposed. Among males, p-values for linear trend were <0.05 for estimated cumulative exposure (all agents) and <0.05 for exposure duration (respirable crystalline silica, chromium-VI, and chromium-VI & nickel); strongest associations were for asbestos at >90%ile cumulative exposure (OR=1.3, CI=1.0-1.6), respirable crystalline silica at 30+ years duration (OR=1.4, CI=1.2-1.7) and 75%-90%ile cumulative exposure (OR=1.4, CI=1.1-1.8), chromium-VI at >75%ile cumulative exposure (OR=1.9, CI=1.2-3.0), and chromium-VI & nickel at 20-29 years duration (OR=1.5, CI=1.1-2.2).CONCLUSIONS: These findings support hypotheses of causal links between four lung carcinogens (asbestos, respirable crystalline silica, chromium-VI, and nickel) and laryngeal cancer.

Published
2020

31. Laryngeal Cancer Risks in Workers Exposed to Lung Carcinogens: Exposure-Effect Analyses Using a Quantitative Job Exposure Matrix

Author

One Health Chemisch, dIRAS RA-2, Hall, Amy L, Kromhout, Hans, Schüz, Joachim, Peters, Susan, Portengen, Lützen, Vermeulen, Roel, Agudo, Antonio, Ahrens, Wolfgang, Boffetta, Paolo, Brennan, Paul, Canova, Cristina, Conway, David I, Curado, Maria Paula, Daudt, Alexander W, Fernandez, Leticia, Hashibe, Mia, Healy, Claire M, Holcatova, Ivana, Kjaerheim, Kristina, Koifman, Rosalina, Lagiou, Pagona, Luce, Danièle, Macfarlane, Gary J, Menezes, Ana, Menvielle, Gwenn, Polesel, Jerry, Ramroth, Heribert, Richiardi, Lorenzo, Stücker, Isabelle, Thomson, Peter, Vilensky, Marta, Wunsch-Filho, Victor, Lee, Yuan-Chin Amy, Znaor, Ariana, Straif, Kurt, Olsson, Ann, One Health Chemisch, dIRAS RA-2, Hall, Amy L, Kromhout, Hans, Schüz, Joachim, Peters, Susan, Portengen, Lützen, Vermeulen, Roel, Agudo, Antonio, Ahrens, Wolfgang, Boffetta, Paolo, Brennan, Paul, Canova, Cristina, Conway, David I, Curado, Maria Paula, Daudt, Alexander W, Fernandez, Leticia, Hashibe, Mia, Healy, Claire M, Holcatova, Ivana, Kjaerheim, Kristina, Koifman, Rosalina, Lagiou, Pagona, Luce, Danièle, Macfarlane, Gary J, Menezes, Ana, Menvielle, Gwenn, Polesel, Jerry, Ramroth, Heribert, Richiardi, Lorenzo, Stücker, Isabelle, Thomson, Peter, Vilensky, Marta, Wunsch-Filho, Victor, Lee, Yuan-Chin Amy, Znaor, Ariana, Straif, Kurt, and Olsson, Ann

Published
2020

32. Age at start of using tobacco on the risk of head and neck cancer: Pooled analysis in the International Head and Neck Cancer Epidemiology Consortium (INHANCE)

Author

Chang, Chun-Pin, primary, Chang, Shen-Chih, additional, Chuang, Shu-Chun, additional, Berthiller, Julien, additional, Ferro, Gilles, additional, Matsuo, Keitaro, additional, Wünsch-Filho, Victor, additional, Toporcov, Tatiana N., additional, de Carvalho, Marcos Brasilino, additional, La Vecchia, Carlo, additional, Olshan, Andrew F., additional, Zevallos, Jose P., additional, Serraino, Diego, additional, Muscat, Joshua, additional, Sturgis, Erich M., additional, Li, Guojun, additional, Morgenstern, Hal, additional, Levi, Fabio, additional, Dal Maso, Luigino, additional, Smith, Elaine, additional, Kelsey, Karl, additional, McClean, Michael, additional, Vaughan, Thomas L., additional, Lazarus, Philip, additional, Ramroth, Heribert, additional, Chen, Chu, additional, Schwartz, Stephen M., additional, Winn, Deborah M., additional, Bosetti, Cristina, additional, Edefonti, Valeria, additional, Garavello, Werner, additional, Negri, Eva, additional, Hayes, Richard B., additional, Purdue, Mark P., additional, Boccia, Stefania, additional, Cadoni, Gabriella, additional, Shangina, Oxana, additional, Koifman, Rosalina, additional, Curado, Maria Paula, additional, Vilensky, Marta, additional, Swiatkowska, Beata, additional, Herrero, Rolando, additional, Franceschi, Silvia, additional, Benhamou, Simone, additional, Fernandez, Leticia, additional, Menezes, Ana M.B., additional, Daudt, Alexander W., additional, Mates, Dana, additional, Schantz, Stimson, additional, Yu, Guo-Pei, additional, Lissowska, Jolanta, additional, Brenner, Hermann, additional, Fabianova, Eleonora, additional, Rudnai, Peter, additional, Brennan, Paul, additional, Boffetta, Paolo, additional, Zhang, Zuo-Feng, additional, Hashibe, Mia, additional, and Lee, Yuan-Chin Amy, additional

Published
2019
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33. Joint effects of intensity and duration of cigarette smoking on the risk of head and neck cancer: A bivariate spline model approach

Author

Di Credico, Gioia, primary, Edefonti, Valeria, additional, Polesel, Jerry, additional, Pauli, Francesco, additional, Torelli, Nicola, additional, Serraino, Diego, additional, Negri, Eva, additional, Luce, Daniele, additional, Stucker, Isabelle, additional, Matsuo, Keitaro, additional, Brennan, Paul, additional, Vilensky, Marta, additional, Fernandez, Leticia, additional, Curado, Maria Paula, additional, Menezes, Ana, additional, Daudt, Alexander W., additional, Koifman, Rosalina, additional, Wunsch-Filho, Victor, additional, Holcatova, Ivana, additional, Ahrens, Wolfgang, additional, Lagiou, Pagona, additional, Simonato, Lorenzo, additional, Richiardi, Lorenzo, additional, Healy, Claire, additional, Kjaerheim, Kristina, additional, Conway, David I., additional, Macfarlane, Tatiana V., additional, Thomson, Peter, additional, Agudo, Antonio, additional, Znaor, Ariana, additional, Boaventura Rios, Leonardo F., additional, Toporcov, Tatiana N., additional, Franceschi, Silvia, additional, Herrero, Rolando, additional, Muscat, Joshua, additional, Olshan, Andrew F., additional, Zevallos, Jose P., additional, La Vecchia, Carlo, additional, Winn, Deborah M., additional, Sturgis, Erich M., additional, Li, Guojun, additional, Fabianova, Eleonora, additional, Lissowska, Jolanda, additional, Mates, Dana, additional, Rudnai, Peter, additional, Shangina, Oxana, additional, Swiatkowska, Beata, additional, Moysich, Kirsten, additional, Zhang, Zuo-Feng, additional, Morgenstern, Hal, additional, Levi, Fabio, additional, Smith, Elaine, additional, Lazarus, Philip, additional, Bosetti, Cristina, additional, Garavello, Werner, additional, Kelsey, Karl, additional, McClean, Michael, additional, Ramroth, Heribert, additional, Chen, Chu, additional, Schwartz, Stephen M., additional, Vaughan, Thomas L., additional, Zheng, Tongzhang, additional, Menvielle, Gwenn, additional, Boccia, Stefania, additional, Cadoni, Gabriella, additional, Hayes, Richard B., additional, Purdue, Mark, additional, Gillison, Maura, additional, Schantz, Stimson, additional, Yu, Guo-Pei, additional, Brenner, Hermann, additional, D'Souza, Gypsyamber, additional, Gross, Neil D., additional, Chuang, Shu-Chun, additional, Boffetta, Paolo, additional, Hashibe, Mia, additional, Lee, Yuan-Chin Amy, additional, and Dal Maso, Luigino, additional

Published
2019
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34. Low frequency of cigarette smoking and the risk of head and neck cancer in the INHANCE consortium pooled analysis

Author

Berthiller, Julien Straif, Kurt Agudo, Antonio Ahrens, Wolfgang dos Santos, Alexandre Bezerra Boccia, Stefania and Cadoni, Gabriella Canova, Cristina Castellsague, Xavier and Chen, Chu Conway, David Curado, Maria Paula Dal Maso, Luigino Daudt, Alexander W. Fabianova, Eleonora Fernandez, Leticia Franceschi, Silvia Fukuyama, Erica E. Hayes, Richard B. Healy, Claire Herrero, Rolando Holcatova, Ivana and Kelsey, Karl Kjaerheim, Kristina Koifman, Sergio Lagiou, Pagona La Vecchia, Carlo Lazarus, Philip Levi, Fabio and Lissowska, Jolanta Macfarlane, Tatiana Mates, Dana McClean, Michael Menezes, Ana Merletti, Franco Morgenstern, Hal and Muscat, Joshua Olshan, Andrew F. Purdue, Mark Ramroth, Heribert Rudnai, Peter Schwartz, Stephen M. Serraino, Diego and Shangina, Oxana Smith, Elaine Sturgis, Erich M. and Szeszenia-Dabrowska, Neonila Thomson, Peter Vaughan, Thomas L. and Vilensky, Marta Wei, Qingyi Winn, Deborah M. and Wunsch-Filho, Victor Zhang, Zuo-Feng Znaor, Ariana Ferro, Gilles Brennan, Paul Boffetta, Paolo Hashibe, Mia Lee, Yuan-Chin Amy

Abstract

Background: Cigarette smoking is a major risk factor for head and neck cancer (HNC). To our knowledge, low cigarette smoking (0-3, >3-5, >5-10 cigarettes per day. Results: Smoking >0-3 cigarettes per day was associated with a 50% increased risk of HNC in the study population [ odds ratio (OR) = 1.52, 95% confidence interval (CI): (1.21, 1.90). Smoking >3-5 cigarettes per day was associated in each subgroup from OR = 2.01 (95% CI: 1.22, 3.31) among never alcohol drinkers to OR = 2.74 (95% CI: 2.01, 3.74) among women and in each cancer site, particularly laryngeal cancer (OR = 3.48, 95% CI: 2.40, 5.05). However, the observed increased risk of HNC for low smoking frequency was not found among smokers with smoking duration shorter than 20 years. Conclusion: Our results suggest a public health message that low frequency of cigarette consumption contributes to the development of HNC. However, smoking duration seems to play at least an equal or a stronger role in the development of HNC.

Published
2016

35. Cessation of alcohol drinking, tobacco smoking and the reversal of head and neck cancer risk

Author

Marron, Manuela, Boffetta, Paolo, Zhang, Zuo-Feng, Zaridze, David, Wünsch-Filho, Victor, Winn, Deborah M., Wei, Qingyi, Talamini, Renato, Szeszenia-Dabrowska, Neonila, Sturgis, Erich M., Smith, Elaine, Schwartz, Stephen M., Rudnai, Peter, Purdue, Mark P., Olshan, Andrew F., Eluf-Neto, Jose, Muscat, Joshua, Morgenstern, Hal, Menezes, Ana, McClean, Michael, Matos, Elena, Mates, Ioan Nicolae, Lissowska, Jolanta, Levi, Fabio, Lazarus, Philip, Vecchia, Carlo La, Koifman, Sergio, Kelsey, Karl, Herrero, Rolando, Hayes, Richard B., Franceschi, Silvia, Fernandez, Leticia, Fabianova, Eleonora, Daudt, Alexander W., Maso, Luigino Dal, Curado, Maria Paula, Cadoni, Gabriella, Chen, Chu, Castellsague, Xavier, Boccia, Stefania, Benhamou, Simone, Ferro, Gilles, Berthiller, Julien, Brennan, Paul, Møller, Henrik, Hashibe, Mia, Marron, Manuela, Boffetta, Paolo, Zhang, Zuo-Feng, Zaridze, David, Wünsch-Filho, Victor, Winn, Deborah M., Wei, Qingyi, Talamini, Renato, Szeszenia-Dabrowska, Neonila, Sturgis, Erich M., Smith, Elaine, Schwartz, Stephen M., Rudnai, Peter, Purdue, Mark P., Olshan, Andrew F., Eluf-Neto, Jose, Muscat, Joshua, Morgenstern, Hal, Menezes, Ana, McClean, Michael, Matos, Elena, Mates, Ioan Nicolae, Lissowska, Jolanta, Levi, Fabio, Lazarus, Philip, Vecchia, Carlo La, Koifman, Sergio, Kelsey, Karl, Herrero, Rolando, Hayes, Richard B., Franceschi, Silvia, Fernandez, Leticia, Fabianova, Eleonora, Daudt, Alexander W., Maso, Luigino Dal, Curado, Maria Paula, Cadoni, Gabriella, Chen, Chu, Castellsague, Xavier, Boccia, Stefania, Benhamou, Simone, Ferro, Gilles, Berthiller, Julien, Brennan, Paul, Møller, Henrik, and Hashibe, Mia

Abstract

Background Quitting tobacco or alcohol use has been reported to reduce the head and neck cancer risk in previous studies. However, it is unclear how many years must pass following cessation of these habits before the risk is reduced, and whether the risk ultimately declines to the level of never smokers or never drinkers. Methods We pooled individual-level data from case-control studies in the International Head and Neck Cancer Epidemiology Consortium. Data were available from 13 studies on drinking cessation (9167 cases and 12 593 controls), and from 17 studies on smoking cessation (12 040 cases and 16 884 controls). We estimated the effect of quitting smoking and drinking on the risk of head and neck cancer and its subsites, by calculating odds ratios (ORs) using logistic regression models. Results Quitting tobacco smoking for 1-4 years resulted in a head and neck cancer risk reduction [OR 0.70, confidence interval (CI) 0.61-0.81 compared with current smoking], with the risk reduction due to smoking cessation after ≥20 years (OR 0.23, CI 0.18-0.31), reaching the level of never smokers. For alcohol use, a beneficial effect on the risk of head and neck cancer was only observed after ≥20 years of quitting (OR 0.60, CI 0.40-0.89 compared with current drinking), reaching the level of never drinkers. Conclusions Our results support that cessation of tobacco smoking and cessation of alcohol drinking protect against the development of head and neck cancer

Published
2017

36. Body mass index and risk of head and neck cancer in a pooled analysis of case-control studies in the International Head and Neck Cancer Epidemiology (INHANCE) Consortium

Author

Gaudet, Mia M., Olshan, Andrew F., Chuang, Shu-Chun, Berthiller, Julien, Zhang, Zuo-Feng, Lissowska, Jolanta, Zaridze, David, Winn, Deborah M., Wei, Qingyi, Talamini, Renato, Szeszenia-Dabrowska, Neolilia, Sturgis, Erich M., Schwartz, Stephen M., Rudnai, Peter, Eluf-Neto, Jose, Muscat, Joshua, Morgenstern, Hal, Menezes, Ana, Matos, Elena, Bucur, Alexandru, Levi, Fabio, Lazarus, Philip, La Vecchia, Carlo, Koifman, Sergio, Kelsey, Karl, Herrero, Rolando, Hayes, Richard B., Franceschi, Silva, Wunsch-Filho, Victor, Fernandez, Leticia, Fabianova, Eleonora, Daudt, Alexander W., Dal Maso, Luigino, Paula Curado, Maria, Chen, Chu, Castellsague, Xavier, Benhamou, Simone, Boffetta, Paolo, Brennan, Paul, Hashibe, Mia, Gaudet, Mia M., Olshan, Andrew F., Chuang, Shu-Chun, Berthiller, Julien, Zhang, Zuo-Feng, Lissowska, Jolanta, Zaridze, David, Winn, Deborah M., Wei, Qingyi, Talamini, Renato, Szeszenia-Dabrowska, Neolilia, Sturgis, Erich M., Schwartz, Stephen M., Rudnai, Peter, Eluf-Neto, Jose, Muscat, Joshua, Morgenstern, Hal, Menezes, Ana, Matos, Elena, Bucur, Alexandru, Levi, Fabio, Lazarus, Philip, La Vecchia, Carlo, Koifman, Sergio, Kelsey, Karl, Herrero, Rolando, Hayes, Richard B., Franceschi, Silva, Wunsch-Filho, Victor, Fernandez, Leticia, Fabianova, Eleonora, Daudt, Alexander W., Dal Maso, Luigino, Paula Curado, Maria, Chen, Chu, Castellsague, Xavier, Benhamou, Simone, Boffetta, Paolo, Brennan, Paul, and Hashibe, Mia

Abstract

Background Head and neck cancer (HNC) risk is elevated among lean people and reduced among overweight or obese people in some studies; however, it is unknown whether these associations differ for certain subgroups or are influenced by residual confounding from the effects of alcohol and tobacco use or by other sources of biases. Methods We pooled data from 17 case-control studies including 12 716 cases and the 17 438 controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated for associations between body mass index (BMI) at different ages and HNC risk, adjusted for age, sex, centre, race, education, tobacco smoking and alcohol consumption. Results Adjusted ORs (95% CIs) were elevated for people with BMI at reference (date of diagnosis for cases and date of selection for controls) ≤18.5 kg/m2 (2.13, 1.75-2.58) and reduced for BMI >25.0-30.0 kg/m2 (0.52, 0.44-0.60) and BMI ≥30 kg/m2 (0.43, 0.33-0.57), compared with BMI >18.5-25.0 kg/m2. These associations did not differ by age, sex, tumour site or control source. Although the increased risk among people with BMI ≤18.5 kg/m2 was not modified by tobacco smoking or alcohol drinking, the inverse association for people with BMI > 25 kg/m2 was present only in smokers and drinkers. Conclusions In our large pooled analysis, leanness was associated with increased HNC risk regardless of smoking and drinking status, although reverse causality cannot be excluded. The reduced risk among overweight or obese people may indicate body size is a modifier of the risk associated with smoking and drinking. Further clarification may be provided by analyses of prospective cohort and mechanistic studies

Published
2017

37. Estimating and explaining the effect of education and income on head and neck cancer risk: INHANCE consortium pooled analysis of 31 case-control studies from 27 countries

Author

Conway, David I., Brenner, Darren R., McMahon, Alex D., Macpherson, Lorna M.D., Agudo, Antonio, Ahrens, Wolfgang, Bosetti, Cristina, Brenner, Hermann, Castellsague, Xavier, Chen, Chu, Curado, Maria Paula, Curioni, Otávio A., Dal Maso, Luigino, Daudt, Alexander W., de Gois Filho, José F., D'Souza, Gypsyamber, Edefonti, Valeria, Fabianova, Eleonora, Fernandez, Leticia, Franceschi, Silvia, Gillison, Maura, Hayes, Richard B., Healy, Claire M., Herrero, Rolando, Holcatova, Ivana, Jayaprakash, Vijayvel, Kelsey, Karl, Kjaerheim, Kristina, Koifman, Sergio, La Vecchia, Carlo, Lagiou, Pagona, Lazarus, Philip, Levi, Fabio, Lissowska, Jolanta, Luce, Daniele, Macfarlane, Tatiana V., Mates, Dana, Matos, Elena, McClean, Michael, Menezes, Ana M., Menvielle, Gwenn, Merletti, Franco, Morgenstern, Hal, Moysich, Kirsten, Müller, Heiko, Muscat, Joshua, Olshan, Andrew F., Purdue, Mark P., Ramroth, Heribert, Richiardi, Lorenzo, Rudnai, Peter, Schantz, Stimson, Schwartz, Stephen M., Shangina, Oxana, Simonato, Lorenzo, Smith, Elaine, Stucker, Isabelle, Sturgis, Erich M., Szeszenia-Dabrowska, Neonila, Talamini, Renato, Thomson, Peter, Vaughan, Thomas L., Wei, Qingyi, Winn, Deborah M., Wunsch-Filho, Victor, Yu, Guo-Pei, Zhang, Zuo-Feng, Zheng, Tongzhang, Znaor, Ariana, Boffetta, Paolo, Chuang, Shu-Chun, Ghodrat, Marianoosh, Amy Lee, Yuan-Chin, Hashibe, Mia, Brennan, Paul, International Prevention Research Institute (IPRI), Conway, D.I., Brenner, D.R., McMahon, A.D., Macpherson, L.M.D., Agudo, A., Ahrens, W., Bosetti, C., Brenner, H., Castellsague, X., Chen, C., Curado, M.P., Curioni, O.A., Maso, L.D., Daudt, A.W., De Gois Filho, J.F., D'Souza, G., Edefonti, V., Fabianova, E., Fernandez, L., Franceschi, S., Gillison, M., Hayes, R.B., Healy, C.M., Herrero, R., Holcatova, I., Jayaprakash, V., Kelsey, K., Kjaerheim, K., Koifman, S., La Vecchia, C., Lagiou, P., Lazarus, P., Levi, F., Lissowska, J., Luce, D., Macfarlane, T.V., Mates, D., Matos, E., McClean, M., Menezes, A.M., Menvielle, G., Merletti, F., Morgenstern, H., Moysich, K., Müller, H., Muscat, J., Olshan, A.F., Purdue, M.P., Ramroth, H., Richiardi, L., Rudnai, P., Schantz, S., Schwartz, S.M., Shangina, O., Simonato, L., Smith, E., Stucker, I., Sturgis, E.M., Szeszenia-Dabrowska, N., Talamini, R., Thomson, P., Vaughan, T.L., Wei, Q., Winn, D.M., Wunsch-Filho, V., Yu, G.-P., Zhang, Z.-F., Zheng, T., Znaor, A., Boffetta, P., Chuang, S.-C., Ghodrat, M., Lee, Y.-C.A., Hashibe, M., and Brennan, P.

Subjects
Male, epidemiology, head and neck cancer, socioeconomic inequalities, Cancer Research, Alcohol Drinking/*adverse effects Case-Control Studies *Education Female Follow-Up Studies Global Health Head and Neck Neoplasms/*etiology Humans Income/*statistics & numerical data Male Meta-Analysis as Topic Middle Aged Prognosis Risk Factors Smoking/*adverse effects Socioeconomic Factors epidemiology head and neck cancer socioeconomic inequalities, Alcohol Drinking, Epidemiology, Head and neck cancer, Socioeconomic inequalities, Case-Control Studies, Female, Follow-Up Studies, Global Health, Head and Neck Neoplasms, Humans, Income, Meta-Analysis as Topic, Middle Aged, Prognosis, Risk Factors, Smoking, Socioeconomic Factors, Education, Oncology, Medicine (all), Article, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
Abstract

Conway, David I Brenner, Darren R McMahon, Alex D Macpherson, Lorna M D Agudo, Antonio Ahrens, Wolfgang Bosetti, Cristina Brenner, Hermann Castellsague, Xavier Chen, Chu Curado, Maria Paula Curioni, Otavio A Dal Maso, Luigino Daudt, Alexander W de Gois Filho, Jose F D'Souza, Gypsyamber Edefonti, Valeria Fabianova, Eleonora Fernandez, Leticia Franceschi, Silvia Gillison, Maura Hayes, Richard B Healy, Claire M Herrero, Rolando Holcatova, Ivana Jayaprakash, Vijayvel Kelsey, Karl Kjaerheim, Kristina Koifman, Sergio La Vecchia, Carlo Lagiou, Pagona Lazarus, Philip Levi, Fabio Lissowska, Jolanta Luce, Daniele Macfarlane, Tatiana V Mates, Dana Matos, Elena McClean, Michael Menezes, Ana M Menvielle, Gwenn Merletti, Franco Morgenstern, Hal Moysich, Kirsten Muller, Heiko Muscat, Joshua Olshan, Andrew F Purdue, Mark P Ramroth, Heribert Richiardi, Lorenzo Rudnai, Peter Schantz, Stimson Schwartz, Stephen M Shangina, Oxana Simonato, Lorenzo Smith, Elaine Stucker, Isabelle Sturgis, Erich M Szeszenia-Dabrowska, Neonila Talamini, Renato Thomson, Peter Vaughan, Thomas L Wei, Qingyi Winn, Deborah M Wunsch-Filho, Victor Yu, Guo-Pei Zhang, Zuo-Feng Zheng, Tongzhang Znaor, Ariana Boffetta, Paolo Chuang, Shu-Chun Ghodrat, Marianoosh Amy Lee, Yuan-Chin Hashibe, Mia Brennan, Paul eng DE016631/DE/NIDCR NIH HHS/ K07CA104231/CA/NCI NIH HHS/ NIDCR R01DE11979/DE/NIDCR NIH HHS/ NIDCRR01DE13110/DE/NIDCR NIH HHS/ NIH FIRCA TW01500/TW/FIC NIH HHS/ P01CA068384/CA/NCI NIH HHS/ P30ES010126/ES/NIEHS NIH HHS/ P50CA090388/CA/NCI NIH HHS/ R01 CA078609/CA/NCI NIH HHS/ R01 CA100679/CA/NCI NIH HHS/ R01CA030022/CA/NCI NIH HHS/ R01CA048996/CA/NCI NIH HHS/ R01CA051845/CA/NCI NIH HHS/ R01CA061188/CA/NCI NIH HHS/ R01CA078609/CA/NCI NIH HHS/ R01CA100264/CA/NCI NIH HHS/ R01CA100679/CA/NCI NIH HHS/ R01CA90731/CA/NCI NIH HHS/ R01DA011386/DA/NIDA NIH HHS/ R01DA026815/DA/NIDA NIH HHS/ R01DE012609/DE/NIDCR NIH HHS/ R01DE013158/DE/NIDCR NIH HHS/ R01ES011740/ES/NIEHS NIH HHS/ R03CA077954/CA/NCI NIH HHS/ R03CA113157/CA/NCI NIH HHS/ R03DE016611/DE/NIDCR NIH HHS/ R21ES011667/ES/NIEHS NIH HHS/ T32CA009142/CA/NCI NIH HHS/ U01CA096134/CA/NCI NIH HHS/ Intramural NIH HHS/ Comparative Study Multicenter Study Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. 2014/07/06 06:00 Int J Cancer. 2015 Mar 1;136(5):1125-39. doi: 10.1002/ijc.29063. Epub 2014 Aug 23.; International audience; Low socioeconomic status has been reported to be associated with head and neck cancer risk. However, previous studies have been too small to examine the associations by cancer subsite, age, sex, global region and calendar time and to explain the association in terms of behavioral risk factors. Individual participant data of 23,964 cases with head and neck cancer and 31,954 controls from 31 studies in 27 countries pooled with random effects models. Overall, low education was associated with an increased risk of head and neck cancer (OR = 2.50; 95% CI = 2.02 - 3.09). Overall one-third of the increased risk was not explained by differences in the distribution of cigarette smoking and alcohol behaviors; and it remained elevated among never users of tobacco and nondrinkers (OR = 1.61; 95% CI = 1.13 - 2.31). More of the estimated education effect was not explained by cigarette smoking and alcohol behaviors: in women than in men, in older than younger groups, in the oropharynx than in other sites, in South/Central America than in Europe/North America and was strongest in countries with greater income inequality. Similar findings were observed for the estimated effect of low versus high household income. The lowest levels of income and educational attainment were associated with more than 2-fold increased risk of head and neck cancer, which is not entirely explained by differences in the distributions of behavioral risk factors for these cancers and which varies across cancer sites, sexes, countries and country income inequality levels.

Published
2015
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38. Risk factors for head and neck cancer in young adults: a pooled analysis in the INHANCE consortium

Author

Toporcov, Tatiana Natasha Znaor, Ariana Zhang, Zuo-Feng Yu, Guo-Pei Winn, Deborah M. Wei, Qingyi Vilensky, Marta and Vaughan, Thomas Thomson, Peter Talamini, Renato and Szeszenia-Dabrowska, Neonila Sturgis, Erich M. Smith, Elaine and Shangina, Oxana Schwartz, Stephen M. Schantz, Stimson and Rudnai, Peter Richiardi, Lorenzo Ramroth, Heribert Purdue, Mark P. Olshan, Andrew F. Eluf-Neto, Jose Muscat, Joshua and Moyses, Raquel Ajub Morgenstern, Hal Menezes, Ana McClean, Michael Matsuo, Keitaro Mates, Dana Macfarlane, Tatiana V. and Lissowska, Jolanta Levi, Fabio Lazarus, Philip La Vecchia, Carlo Lagiou, Pagona Koifman, Sergio Kjaerheim, Kristina Kelsey, Karl Holcatova, Ivana Herrero, Rolando and Healy, Claire Hayes, Richard B. Franceschi, Silvia and Fernandez, Leticia Fabianova, Eleonora Daudt, Alexander W. and Curioni, Otavio Alberto Dal Maso, Luigino Curado, Maria Paula and Conway, David I. Chen, Chu Castellsague, Xavier Canova, Cristina Cadoni, Gabriella Brennan, Paul Boccia, Stefania and Antunes, Jose Leopoldo Ferreira Ahrens, Wolfgang Agudo, Antonio Boffetta, Paolo Hashibe, Mia Lee, Yuan-Chin Amy and Wuensch Filho, Victor

Abstract

Background: Increasing incidence of head and neck cancer (HNC) in young adults has been reported. We aimed to compare the role of major risk factors and family history of cancer in HNC in young adults and older patients. Methods: We pooled data from 25 case-control studies and conducted separate analyses for adults 45 years old (’older adults’, 17 700 cases and 22 704 controls). Using logistic regression with studies treated as random effects, we estimated adjusted odds ratios (ORs) and 95% confidence intervals (CIs). Results: The young group of cases had a higher proportion of oral tongue cancer (16.0% in women; 11.0% in men) and unspecified oral cavity / oropharynx cancer (16.2%; 11.1%) and a lower proportion of larynx cancer (12.1%; 16.6%) than older adult cases. The proportions of never smokers or never drinkers among female cases were higher than among male cases in both age groups. Positive associations with HNC and duration or pack-years of smoking and drinking were similar across age groups. However, the attributable fractions (AFs) for smoking and drinking were lower in young when compared with older adults (AFs for smoking in young women, older women, young men and older men, respectively, =19.9% (95% CI = 9.8%, 27.9%), 48.9% (46.6%, 50.8%), 46.2% (38.5%, 52.5%), 64.3% (62.2%, 66.4%); AFs for drinking = 5.3% (-11.2%, 18.0%), 20.0% (14.5%, 25.0%), 21.5% (5.0%, 34.9%) and 50.4% (46.1%, 54.3%). A family history of early-onset cancer was associated with HNC risk in the young [OR = 2.27 (95% CI = 1.26, 4.10)], but not in the older adults [OR = 1.10 (0.91, 1.31)]. The attributable fraction for family history of early-onset cancer was 23.2% (8.60% to 31.4%) in young compared with 2.20% (-2 .41%, 5.80%) in older adults. Conclusions: Differences in HNC aetiology according to age group may exist. The lower AF of cigarette smoking and alcohol drinking in young adults may be due to the reduced length of exposure due to the lower age. Other characteristics, such as those that are inherited, may play a more important role in HNC in young adults compared with older adults.

Published
2015

39. Mouthwash use and cancer of the head and neck: a pooled analysis from the International Head and Neck Cancer Epidemiology Consortium.

Author

Boffetta, Paolo, Boffetta, Paolo, Hayes, Richard B, Sartori, Samantha, Lee, Yuan-Chin A, Muscat, Joshua, Olshan, Andrew, Winn, Deborah M, Castellsagué, Xavier, Zhang, Zuo-Feng, Morgenstern, Hal, Chen, Chu, Schwartz, Stephen M, Vaughan, Thomas L, Wunsch-Filho, Victor, Purdue, Mark, Koifman, Sergio, Curado, Maria P, Vilensky, Marta, Gillison, Maura, Fernandez, Leticia, Menezes, Ana, Daudt, Alexander W, Schantz, Stimson, Yu, Guopei, D'Souza, Gypsyamber, Haddad, Robert I, La Vecchia, Carlo, Hashibe, Mia, Boffetta, Paolo, Boffetta, Paolo, Hayes, Richard B, Sartori, Samantha, Lee, Yuan-Chin A, Muscat, Joshua, Olshan, Andrew, Winn, Deborah M, Castellsagué, Xavier, Zhang, Zuo-Feng, Morgenstern, Hal, Chen, Chu, Schwartz, Stephen M, Vaughan, Thomas L, Wunsch-Filho, Victor, Purdue, Mark, Koifman, Sergio, Curado, Maria P, Vilensky, Marta, Gillison, Maura, Fernandez, Leticia, Menezes, Ana, Daudt, Alexander W, Schantz, Stimson, Yu, Guopei, D'Souza, Gypsyamber, Haddad, Robert I, La Vecchia, Carlo, and Hashibe, Mia

Abstract

Most mouthwashes contain alcohol, a known cause of head and neck cancer (oral cavity, pharynx, larynx), likely through the carcinogenic activity of acetaldehyde, formed in the oral cavity from alcohol. We carried out a pooled analysis of 8981 cases of head and neck cancer and 10 090 controls from 12 case-control studies with comparable information on mouthwash use in the International Head and Neck Cancer Epidemiology Consortium. Logistic regression was used to assess the association of mouthwash use with cancers of the oral cavity, oropharynx, hypopharynx, and larynx, adjusting for study, age, sex, pack-years of tobacco smoking, number of alcoholic drinks/day, and education. Compared with never users of mouthwash, the odds ratio (OR) of all head and neck cancers was 1.01 [95% confidence interval (CI): 0.94-1.08] for ever users, based on 12 studies. The corresponding ORs of cancer of the oral cavity and oropharynx were 1.11 (95% CI: 1.00-1.23) and 1.28 (95% CI: 1.06-1.56), respectively. OR for all head and neck cancer was 1.15 (95% CI: 1.01-1.30) for use for more than 35 years, based on seven studies (P for linear trend=0.01), and OR 1.31 (95% CI: 1.09-1.58) for use more than one per day, based on five studies (P for linear trend <0.001). Although limited by the retrospective nature of the study and the limited ability to assess risks of mouthwash use in nonusers of tobacco and alcohol, this large investigation shows potential risks for head and neck cancer subsites and in long-term and frequent users of mouthwash. This pooled analysis provides the most precise estimate of the association between mouthwash use and head and neck cancer.

Published
2016

40. Adult height and head and neck cancer: a pooled analysis within the INHANCE Consortium

Author

Leoncini, Emanuele Ricciardi, Walter Cadoni, Gabriella and Arzani, Dario Petrelli, Livia Paludetti, Gaetano Brennan, Paul Luce, Daniele Stucker, Isabelle Matsuo, Keitaro and Talamini, Renato La Vecchia, Carlo Olshan, Andrew F. Winn, Deborah M. Herrero, Rolando Franceschi, Silvia Castellsague, Xavier Muscat, Joshua Morgenstern, Hal Zhang, Zuo-Feng and Levi, Fabio Dal Maso, Luigino Kelsey, Karl McClean, Michael and Vaughan, Thomas L. Lazarus, Philip Purdue, Mark P. and Hayes, Richard B. Chen, Chu Schwartz, Stephen M. Shangina, Oxana Koifman, Sergio Ahrens, Wolfgang Matos, Elena and Lagiou, Pagona Lissowska, Jolanta Szeszenia-Dabrowska, Neonila and Fernandez, Leticia Menezes, Ana Agudo, Antonio Daudt, Alexander W. Richiardi, Lorenzo Kjaerheim, Kristina Mates, Dana Betka, Jaroslav Yu, Guo-Pei Schantz, Stimson and Simonato, Lorenzo Brenner, Hermann Conway, David I. and Macfarlane, Tatiana V. Thomson, Peter Fabianova, Eleonora and Znaor, Ariana Rudnai, Peter Healy, Claire Boffetta, Paolo and Chuang, Shu-Chun Lee, Yuan-Chin Amy Hashibe, Mia Boccia, Stefania

Abstract

Several epidemiological studies have shown a positive association between adult height and cancer incidence. The only study conducted among women on mouth and pharynx cancer risk, however, reported an inverse association. This study aims to investigate the association between height and the risk of head and neck cancer (HNC) within a large international consortium of HNC. We analyzed pooled individual-level data from 24 case-control studies participating in the International Head and Neck Cancer Epidemiology Consortium. Odds ratios (ORs) and 95 % confidence intervals (CIs) were estimated separately for men and women for associations between height and HNC risk. Educational level, tobacco smoking, and alcohol consumption were included in all regression models. Stratified analyses by HNC subsites were performed. This project included 17,666 cases and 28,198 controls. We found an inverse association between height and HNC (adjusted OR per 10 cm height = 0.91, 95 % CI 0.86-0.95 for men; adjusted OR = 0.86, 95 % CI 0.79-0.93 for women). In men, the estimated OR did vary by educational level, smoking status, geographic area, and control source. No differences by subsites were detected. Adult height is inversely associated with HNC risk. As height can be considered a marker of childhood illness and low energy intake, the inverse association is consistent with prior studies showing that HNC occur more frequently among deprived individuals. Further studies designed to elucidate the mechanism of such association would be warranted.

Published
2014

41. Low frequency of cigarette smoking and the risk of head and neck cancer in the INHANCE consortium pooled analysis

Author

Berthiller, Julien, primary, Straif, Kurt, additional, Agudo, Antonio, additional, Ahrens, Wolfgang, additional, Bezerra dos Santos, Alexandre, additional, Boccia, Stefania, additional, Cadoni, Gabriella, additional, Canova, Cristina, additional, Castellsague, Xavier, additional, Chen, Chu, additional, Conway, David, additional, Curado, Maria Paula, additional, Dal Maso, Luigino, additional, Daudt, Alexander W, additional, Fabianova, Eleonora, additional, Fernandez, Leticia, additional, Franceschi, Silvia, additional, Fukuyama, Erica E, additional, Hayes, Richard B, additional, Healy, Claire, additional, Herrero, Rolando, additional, Holcatova, Ivana, additional, Kelsey, Karl, additional, Kjaerheim, Kristina, additional, Koifman, Sergio, additional, Lagiou, Pagona, additional, La Vecchia, Carlo, additional, Lazarus, Philip, additional, Levi, Fabio, additional, Lissowska, Jolanta, additional, Macfarlane, Tatiana, additional, Mates, Dana, additional, McClean, Michael, additional, Menezes, Ana, additional, Merletti, Franco, additional, Morgenstern, Hal, additional, Muscat, Joshua, additional, Olshan, Andrew F, additional, Purdue, Mark, additional, Ramroth, Heribert, additional, Rudnai, Peter, additional, Schwartz, Stephen M, additional, Serraino, Diego, additional, Shangina, Oxana, additional, Smith, Elaine, additional, Sturgis, Erich M, additional, Szeszenia-Dabrowska, Neonila, additional, Thomson, Peter, additional, Vaughan, Thomas L, additional, Vilensky, Marta, additional, Wei, Qingyi, additional, Winn, Deborah M, additional, Wünsch-Filho, Victor, additional, Zhang, Zuo-Feng, additional, Znaor, Ariana, additional, Ferro, Gilles, additional, Brennan, Paul, additional, Boffetta, Paolo, additional, Hashibe, Mia, additional, and Lee, Yuan-Chin Amy, additional

Published
2015
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42. Body mass index and risk of head and neck cancer in a pooled analysis of case–control studies in the International Head and Neck Cancer Epidemiology (INHANCE) Consortium

Author

Koifman, Sergio, Herrero, Rolando, Winn, Deborah M, Szeszenia-Dabrowska, Neolilia, Muscat, Joshua, Kelsey, Karl, Fernandez, Leticia, Gaudet, Mia M, Levi, Fabio, Lissowska, Jolanta, La Vecchia, Carlo, Sturgis, Erich M, Matos, Elena, Hayes, Richard B, Wunsch-Filho, Victor, Berthiller, Julien, Eluf-Neto, Jose, Menezes, Ana, Bucur, Alexandru, Morgenstern, Hal, Olshan, Andrew F, Franceschi, Silva, Daudt, Alexander W, Zhang, Zuo-Feng, Lazarus, Philip, Talamini, Renato, Rudnai, Peter, Wei, Qingyi, Zaridze, David, Chuang, Shu-Chun, Schwartz, Stephen M, and Fabianova, Eleonora

Abstract

Background Head and neck cancer (HNC) risk is elevated among lean people and reduced among overweight or obese people in some studies; however, it is unknown whether these associations differ for certain subgroups or are influenced by residual confounding from the effects of alcohol and tobacco use or by other sources of biases.

Published
2010
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43. Interaction between tobacco and alcohol use and the risk of head and neck cancer: pooled analysis in the INHANCE consortium

Author

Hashibe, Mia, Brennan, Paul, Chuang, Shu-chun, Boccia, Stefania, Castellsague, Xavier, Chen, Chu, Curado, Maria Paula, Maso, Luigino Dal, Daudt, Alexander W., Fabianova, Eleonora, Fernandez, Leticia, Wünsch-Filho, Victor, Franceschi, Silvia, Hayes, Richard B., Herrero, Rolando, Kelsey, Karl, Koifman, Sergio, La Vecchia, Carlo, Lazarus, Philip, Levi, Fabio, Lence, Juan J., Mates, Dana, Matos, Elena, Menezes, Ana, McClean, Michael D., Muscat, Joshua, Eluf-Neto, Jose, Olshan, Andrew F., Purdue, Mark, Rudnai, Peter, Schwartz, Stephen M., Smith, Elaine, Sturgis, Erich M., Szeszenia-Dabrowska, Neonilia, Talamini, Renato, Wei, Qingyi, Winn, Deborah M., Shangina, Oxana, Pilarska, Agnieszka, Zhang, Zuo-Feng, Ferro, Gilles, Berthiller, Julien, and Boffetta, Paolo

Subjects
Adult, Male, Alcohol Drinking, Tobacco Use Disorder, Middle Aged, Article, Europe, Logistic Models, Head and Neck Neoplasms, Risk Factors, Case-Control Studies, North America, Humans, Female, Aged
Abstract

The magnitude of risk conferred by the interaction between tobacco and alcohol use on the risk of head and neck cancers is not clear because studies have used various methods to quantify the excess head and neck cancer burden.We analyzed individual-level pooled data from 17 European and American case-control studies (11,221 cases and 16,168 controls) participating in the International Head and Neck Cancer Epidemiology consortium. We estimated the multiplicative interaction parameter (psi) and population attributable risks (PAR).A greater than multiplicative joint effect between ever tobacco and alcohol use was observed for head and neck cancer risk (psi = 2.15; 95% confidence interval, 1.53-3.04). The PAR for tobacco or alcohol was 72% (95% confidence interval, 61-79%) for head and neck cancer, of which 4% was due to alcohol alone, 33% was due to tobacco alone, and 35% was due to tobacco and alcohol combined. The total PAR differed by subsite (64% for oral cavity cancer, 72% for pharyngeal cancer, 89% for laryngeal cancer), by sex (74% for men, 57% for women), by age (33% for cases45 years, 73% for cases60 years), and by region (84% in Europe, 51% in North America, 83% in Latin America).Our results confirm that the joint effect between tobacco and alcohol use is greater than multiplicative on head and neck cancer risk. However, a substantial proportion of head and neck cancers cannot be attributed to tobacco or alcohol use, particularly for oral cavity cancer and for head and neck cancer among women and among young-onset cases.

Published
2009

44. Family history of cancer: Pooled analysis in the International Head and Neck Cancer Epidemiology Consortium

Author

Eluf-Neto, Jose, Lissowska, Jolanta, Olshan, Andrew F., Fabianova, Eleonora, Talamini, Renato, Fernandez, Leticia, Maso, Luigino Dal, Franceschi, Silvia, Zaridze, David, Szeszenia-Dabrowska, Neonilia, Matos, Elena, Daudt, Alexander W., Muscat, Joshua, Koifman, Sergio, Lazarus, Philip, Menezes, Ana, Hayes, Richard B., Lence, Juan J., Curado, Maria Paula, Herrero, Rolando, Boffetta, Paolo, Mates, Dana, Winn, Deborah M., Shangina, Oxana, Levi, Fabio, Rudnai, Peter, Sturgis, Erich M., Negri, Eva, Wei, Qingyi, Wünsch-Filho, Victor, Castellsague, Xavier, and Berthiller, Julien

Abstract

Alcohol and tobacco consumption are well recognized risk factors for head and neck cancer (HNC). Evidence suggests that genetic predisposition may also play a role. Only a few epidemiologic studies, however, have considered the relation between HNC risk and family history of HNC and other cancers. We pooled individual- level data across 12 case-control studies including 8,967 HNC cases and 13,627 controls. We obtained pooled odds ratios (OR) using fixed and random effect models, and adjusting for potential confounding factors. All statistical tests were two-sided. A family history of HNC in first-degree relatives increased the risk of HNC (OR=1.7, 95% confidence interval, CI, 1.2-2.3). The risk was higher when the affected relative was a sibling (OR=2.2, 95% CI 1.6-3.1) rather than a parent (OR=1.5, 95% CI 1.1-1.8), and for more distal HNC anatomic sites (hypopharynx and larynx). The risk was also higher, or limited to, subjects exposed to tobacco. The OR rose to 7.2 (95% CI 5.5-9.5) among subjects with family history, who were alcohol and tobacco users. A weak but significant association (OR=1.1, 95% CI 1.0-1.2) emerged for family history of other tobacco-related neoplasms, particularly with laryngeal cancer (OR=1.3, 95% CI 1.1-1.5). No association was observed for family history of non-tobacco related neoplasms and the risk of HNC (OR=1.0, 95% CI 0.9-1.1). Familial factors play a role in the etiology of HNC. In both subjects with and without family history of HNC, avoidance of tobacco and alcohol exposure may be the best way to avoid HNC.

Published
2009
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45. Estimating and explaining the effect of education and income on head and neck cancer risk: INHANCE consortium pooled analysis of 31 case‐control studies from 27 countries

Author

Conway, David I., primary, Brenner, Darren R., additional, McMahon, Alex D., additional, Macpherson, Lorna M.D., additional, Agudo, Antonio, additional, Ahrens, Wolfgang, additional, Bosetti, Cristina, additional, Brenner, Hermann, additional, Castellsague, Xavier, additional, Chen, Chu, additional, Curado, Maria Paula, additional, Curioni, Otávio A., additional, Dal Maso, Luigino, additional, Daudt, Alexander W., additional, de Gois Filho, José F., additional, D'Souza, Gypsyamber, additional, Edefonti, Valeria, additional, Fabianova, Eleonora, additional, Fernandez, Leticia, additional, Franceschi, Silvia, additional, Gillison, Maura, additional, Hayes, Richard B., additional, Healy, Claire M., additional, Herrero, Rolando, additional, Holcatova, Ivana, additional, Jayaprakash, Vijayvel, additional, Kelsey, Karl, additional, Kjaerheim, Kristina, additional, Koifman, Sergio, additional, La Vecchia, Carlo, additional, Lagiou, Pagona, additional, Lazarus, Philip, additional, Levi, Fabio, additional, Lissowska, Jolanta, additional, Luce, Daniele, additional, Macfarlane, Tatiana V., additional, Mates, Dana, additional, Matos, Elena, additional, McClean, Michael, additional, Menezes, Ana M, additional, Menvielle, Gwenn, additional, Merletti, Franco, additional, Morgenstern, Hal, additional, Moysich, Kirsten, additional, Müller, Heiko, additional, Muscat, Joshua, additional, Olshan, Andrew F., additional, Purdue, Mark P., additional, Ramroth, Heribert, additional, Richiardi, Lorenzo, additional, Rudnai, Peter, additional, Schantz, Stimson, additional, Schwartz, Stephen M., additional, Shangina, Oxana, additional, Simonato, Lorenzo, additional, Smith, Elaine, additional, Stucker, Isabelle, additional, Sturgis, Erich M., additional, Szeszenia‐Dabrowska, Neonila, additional, Talamini, Renato, additional, Thomson, Peter, additional, Vaughan, Thomas L., additional, Wei, Qingyi, additional, Winn, Deborah M., additional, Wunsch‐Filho, Victor, additional, Yu, Guo‐Pei, additional, Zhang, Zuo‐Feng, additional, Zheng, Tongzhang, additional, Znaor, Ariana, additional, Boffetta, Paolo, additional, Chuang, Shu‐Chun, additional, Ghodrat, Marianoosh, additional, Amy Lee, Yuan‐Chin, additional, Hashibe, Mia, additional, and Brennan, Paul, additional

Published
2014
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46. Cessation of alcohol drinking, tobacco smoking and the reversal of head and neck cancer risk

Author

Manuela, Marron, Boffetta, Paolo, Zaridze, David, Winn, Deborah M, Talamini, Renato, Sturgis, Erich M, Schwartz, Stephen M, Purdue, Mark P, Eluf Neto, Jose, Mcclean, Michael, Mates, Ioan Nicolae, La Vecchia, Carlo, Hayes, Richard B, Fernandez, Leticia, Daudt, Alexander W, Curado, Maria Paula, Cadoni, Gabriella, Chen, Chu, Boccia, Stefania, Ferro, Gille, Brennan, Paul, Hashibe, Mia, Cadoni, Gabriella (ORCID:0000-0001-8244-784X), Boccia, Stefania (ORCID:0000-0002-1864-749X), Manuela, Marron, Boffetta, Paolo, Zaridze, David, Winn, Deborah M, Talamini, Renato, Sturgis, Erich M, Schwartz, Stephen M, Purdue, Mark P, Eluf Neto, Jose, Mcclean, Michael, Mates, Ioan Nicolae, La Vecchia, Carlo, Hayes, Richard B, Fernandez, Leticia, Daudt, Alexander W, Curado, Maria Paula, Cadoni, Gabriella, Chen, Chu, Boccia, Stefania, Ferro, Gille, Brennan, Paul, Hashibe, Mia, Cadoni, Gabriella (ORCID:0000-0001-8244-784X), and Boccia, Stefania (ORCID:0000-0002-1864-749X)

Abstract

BACKGROUND: Quitting tobacco or alcohol use has been reported to reduce the head and neck cancer risk in previous studies. However, it is unclear how many years must pass following cessation of these habits before the risk is reduced, and whether the risk ultimately declines to the level of never smokers or never drinkers. METHODS: We pooled individual-level data from case-control studies in the International Head and Neck Cancer Epidemiology Consortium. Data were available from 13 studies on drinking cessation (9167 cases and 12 593 controls), and from 17 studies on smoking cessation (12 040 cases and 16 884 controls). We estimated the effect of quitting smoking and drinking on the risk of head and neck cancer and its subsites, by calculating odds ratios (ORs) using logistic regression models. RESULTS: Quitting tobacco smoking for 1-4 years resulted in a head and neck cancer risk reduction [OR 0.70, confidence interval (CI) 0.61-0.81 compared with current smoking], with the risk reduction due to smoking cessation after > or =20 years (OR 0.23, CI 0.18-0.31), reaching the level of never smokers. For alcohol use, a beneficial effect on the risk of head and neck cancer was only observed after > or =20 years of quitting (OR 0.60, CI 0.40-0.89 compared with current drinking), reaching the level of never drinkers. CONCLUSIONS: Our results support that cessation of tobacco smoking and cessation of alcohol drinking protect against the development of head and neck cancer

Published
2010

47. Adult height and head and neck cancer: a pooled analysis within the INHANCE Consortium

Author

Leoncini, Emanuele, primary, Ricciardi, Walter, additional, Cadoni, Gabriella, additional, Arzani, Dario, additional, Petrelli, Livia, additional, Paludetti, Gaetano, additional, Brennan, Paul, additional, Luce, Daniele, additional, Stucker, Isabelle, additional, Matsuo, Keitaro, additional, Talamini, Renato, additional, La Vecchia, Carlo, additional, Olshan, Andrew F., additional, Winn, Deborah M., additional, Herrero, Rolando, additional, Franceschi, Silvia, additional, Castellsague, Xavier, additional, Muscat, Joshua, additional, Morgenstern, Hal, additional, Zhang, Zuo-Feng, additional, Levi, Fabio, additional, Dal Maso, Luigino, additional, Kelsey, Karl, additional, McClean, Michael, additional, Vaughan, Thomas L., additional, Lazarus, Philip, additional, Purdue, Mark P., additional, Hayes, Richard B., additional, Chen, Chu, additional, Schwartz, Stephen M., additional, Shangina, Oxana, additional, Koifman, Sergio, additional, Ahrens, Wolfgang, additional, Matos, Elena, additional, Lagiou, Pagona, additional, Lissowska, Jolanta, additional, Szeszenia-Dabrowska, Neonila, additional, Fernandez, Leticia, additional, Menezes, Ana, additional, Agudo, Antonio, additional, Daudt, Alexander W., additional, Richiardi, Lorenzo, additional, Kjaerheim, Kristina, additional, Mates, Dana, additional, Betka, Jaroslav, additional, Yu, Guo-Pei, additional, Schantz, Stimson, additional, Simonato, Lorenzo, additional, Brenner, Hermann, additional, Conway, David I., additional, Macfarlane, Tatiana V., additional, Thomson, Peter, additional, Fabianova, Eleonora, additional, Znaor, Ariana, additional, Rudnai, Peter, additional, Healy, Claire, additional, Boffetta, Paolo, additional, Chuang, Shu-Chun, additional, Lee, Yuan-Chin Amy, additional, Hashibe, Mia, additional, and Boccia, Stefania, additional

Published
2013
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48. Diet and the risk of head and neck cancer: a pooled analysis in the INHANCE consortium

Author

Chuang, Shu-Chun, primary, Jenab, Mazda, additional, Heck, Julia E., additional, Bosetti, Cristina, additional, Talamini, Renato, additional, Matsuo, Keitaro, additional, Castellsague, Xavier, additional, Franceschi, Silvia, additional, Herrero, Rolando, additional, Winn, Deborah M., additional, Vecchia, Carlo La, additional, Morgenstern, Hal, additional, Zhang, Zuo-Feng, additional, Levi, Fabio, additional, Maso, Luigino Dal, additional, Kelsey, Karl, additional, McClean, Michael D., additional, Vaughan, Thomas, additional, Lazarus, Philip, additional, Muscat, Joshua, additional, Ramroth, Heribert, additional, Chen, Chu, additional, Schwartz, Stephen M., additional, Eluf-Neto, Jose, additional, Hayes, Richard B., additional, Purdue, Mark, additional, Boccia, Stefania, additional, Cadoni, Gabriella, additional, Zaridze, David, additional, Koifman, Sergio, additional, Curado, Maria Paula, additional, Ahrens, Wolfgang, additional, Benhamou, Simone, additional, Matos, Elena, additional, Lagiou, Pagona, additional, Szeszenia-Dabrowska, Neonilla, additional, Olshan, Andrew F., additional, Fernandez, Leticia, additional, Menezes, Ana, additional, Agudo, Antonio, additional, Daudt, Alexander W., additional, Merletti, Franco, additional, Macfarlane, Gary J., additional, Kjaerheim, Kristina, additional, Mates, Dana, additional, Holcatova, Ivana, additional, Schantz, Stimson, additional, Yu, Guo-Pei, additional, Simonato, Lorenzo, additional, Brenner, Hermann, additional, Mueller, Heiko, additional, Conway, David I., additional, Thomson, Peter, additional, Fabianova, Eleonora, additional, Znaor, Ariana, additional, Rudnai, Peter, additional, Healy, Claire M., additional, Ferro, Gilles, additional, Brennan, Paul, additional, Boffetta, Paolo, additional, and Hashibe, Mia, additional

Published
2011
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49. Abstract 2818: Vitamin or mineral supplement intake and the risk of head and neck cancer: Pooled analysis in the INHANCE consortium

Author

Li, Qian, primary, Chuang, Shu-chun, additional, Neto, Jose Eluf, additional, Menezes, Ana, additional, Matos, Elena, additional, Koifman, Sergio, additional, Wunsch-Filho, Victor, additional, Fernandez, Leticia, additional, Daudt, Alexander W., additional, Curado, Maria Paula, additional, Winn, Debborah M., additional, Franceschi, Silvia, additional, Herrero, Rolando, additional, Castellsague, Xavier, additional, Zhang, Zuo-Feng, additional, Lazarus, Philip, additional, Muscat, Joshua, additional, McClean, Michael, additional, Kelsey, Karl T., additional, Hayes, Richard B., additional, Schwartz, Stephen M., additional, Chen, Chu, additional, Benhamou, Simone, additional, Olshan, Andrew F., additional, Schantz, Stimson, additional, Boffetta, Paolo, additional, Ferro, Gilles, additional, Brennan, Paul, additional, and Hashibe, Mia, additional

Published
2010
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50. Sexual behaviours and the risk of head and neck cancers: a pooled analysis in the International Head and Neck Cancer Epidemiology (INHANCE) consortium

Author

Heck, Julia E, primary, Berthiller, Julien, additional, Vaccarella, Salvatore, additional, Winn, Deborah M, additional, Smith, Elaine M, additional, Shan'gina, Oxana, additional, Schwartz, Stephen M, additional, Purdue, Mark P, additional, Pilarska, Agnieszka, additional, Eluf-Neto, Jose, additional, Menezes, Ana, additional, McClean, Michael D, additional, Matos, Elena, additional, Koifman, Sergio, additional, Kelsey, Karl T, additional, Herrero, Rolando, additional, Hayes, Richard B, additional, Franceschi, Silvia, additional, Wünsch-Filho, Victor, additional, Fernández, Leticia, additional, Daudt, Alexander W, additional, Curado, Maria Paula, additional, Chen, Chu, additional, Castellsagué, Xavier, additional, Ferro, Gilles, additional, Brennan, Paul, additional, Boffetta, Paolo, additional, and Hashibe, Mia, additional

Published
2009
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