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Social media is increasingly used for health queries and subspecialist selection, but physicians receive little training in its use. This case study describes use of the free data tool Facebook Audience Insights to understand population demographics relevant to an orthopedic practice. Facebook Audience Insights was used to compare demographics and activity patterns of two patient samples typical of total joint arthroplasty (TJA)—young TJA (ages 55–64 years) and Medicare TJA (age ≥65 years)—in May 2020. Creation of a professional Facebook page is described accompanied by the demonstration of Audience Insights to analyze regional user patterns. A local sample of Facebook users was then compared with a single orthopedic practice's Facebook traffic. Facebook use is common among patients undergoing TJA, and the proportion of self-identified women increases with age (young TJA, 53% women; Medicare TJA, 63% women). Women are more interactive Facebook users across all age ranges, with more frequent comments, "Liked" pages, and advertisement clicks. Analysis of a local Facebook population revealed a lower proportion of TJA-aged patients than the national cohort; however, TJA-aged patients represented 38% of the practice's Facebook page traffic, with a predominance of visitors being women (26% women, 12% men). Facebook demonstrates a high prevalence of users in the typical age range for TJA. Those users were common on an orthopedic practice Facebook page, suggesting social media may be an effective medium for engaging patients. [Orthopedics. 2024;47(2):e79–e84.] [ABSTRACT FROM AUTHOR]

Following burn injury, the host is susceptible to bacterial infections normally cleared by healthy patients. We hypothesized that during the systemic immune response that follows scald injury, the host's altered immune status increases infection susceptibility. Using a murine model of scald injury under inhaled anesthesia followed by intraperitoneal infection, we observed increased neutrophil numbers and function at postburn day (PBD) 1 compared with sham-burned and PBD4 mice. Further, increased mortality, bacteremia, and serum IL-6 were observed in PBD 1 mice after Pseudomonas aeruginosa (PA) infection compared with sham-burned and PBD4 mice infected with PA. To examine these disparate responses, we investigated neutrophils isolated at 5 and 24 h following PA infection from PBD1 and sham-burned mice. Five hours after infection, there was no significant difference in number of recruited neutrophils; however, neutrophils from injured mice had decreased activation, active-p38, and oxidative burst compared with sham-burned mice. In direct contrast, 24 h after infection, we observed increased numbers, active-p38, and oxidative burst of neutrophils from PBD1 mice. Finally, we demonstrated that in neutrophils isolated from PBD1 mice, the observed increase in oxidative burst was p38 dependent. Altogether, neutrophil activation and function from thermally injured mice are initially delayed and later exacerbated by a p38-dependent mechanism. This mechanism is likely key to the observed increase in bacterial load and mortality of PBD1 mice infected with PA. trauma; immune status; oxidative burst; murine doi: 10.1152/ajpregu.00132.2010.

The purpose of this study is to evaluate the fluid volume required for a saline load test to detect intra-articular involvement of the glenohumeral joint after penetrating trauma. A human cadaver study was conducted with 22 thawed, fresh-frozen forequarter amputations. A standard posterior shoulder portal was made with an 11-blade scalpel. A 19-gauge needle was inserted into the anterior portal site, and intra-articular position of both the blade and needle was confirmed with fluoroscopy. The blade was removed and normal saline was injected through the needle until extravasation of fluid was observed through the posterior portal. Injection volume required for extravasation was recorded. A logarithmic distribution of the volumes was then calculated in order to obtain estimated sensitivity ranges. Using a logarithmic distribution, 90%, 95% and 99% of simulated glenohumeral arthrotomies could be detected using injections of: 62 ml [41-96], 81 ml [50-133] and 136 ml [72-252], respectively. (Journal of Surgical Orthopaedic Advances 28(4):268-271, 2019).