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19 results on '"Dassamiour, Saliha"'

3. HPLC-DAD phenolics screening and in vitro investigation of haemostatic, antidiabetic, antioxidant and photoprotective properties of Centaurea tougourensis Boiss. & Reut.

Author

Bensaad Mohamed Sabri, Dassamiour Saliha, Hambaba Leila, Bensouici Chawki, Karima Ouffroukh, and Kahoul Mohamed Amine

Subjects
centaurea tougourensis, hplc-dad, phenolics, pharmacological properties, Plant culture, SB1-1110
Abstract

Traditional medicine has an important place in human history and this since antiquity. Indeed, during Egyptian and Chinese civilization era, many detailed manuscripts, describing the therapeutic effect of plants, were found which suggest that folk medicine is the basis of the actual medicine.

Published
2021
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4. Antihyperglycemic Potential of Methanolic Extracts from the Medicinal Plants: Marrubium deserti De Noé and Marrubium vulgare L.

Author

Ghedadba, Nabil, primary, Hambaba, Leila, additional, Hachemi, Massoud, additional, Bensaad, Mohamed Sabri, additional, Dassamiour, Saliha, additional, Sami, Rokayya, additional, Alshehry, Garsa, additional, Alsharari, Zayed D., additional, Waggas, Dania S., additional, Algehainy, Naseh A., additional, Noorwali, Essra A., additional, Almehmadi, Awatif M., additional, Abushal, Suzan A., additional, Al-Eisa, Rasha A., additional, Althobaiti, Fayez, additional, and Shaer, Nehad A., additional

Published
2024
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7. In vitro assessment of antioxidant, anti-inflammatory, neuroprotective and antimicrobial activities of Centaurea tougourensis Boiss. & Reut

Author

Bensaad, Mohamed Sabri, Dassamiour, Saliha, Hambaba, Leila, Bensouici, Chawki, and Hamada Haba

Subjects
Pharmacology, antioxidant, Pharmaceutical Science, neuroprotective, Pharmacy, centaurea tougourensis, RM1-950, RS1-441, Pharmacy and materia medica, Complementary and alternative medicine, Drug Discovery, antimicrobial, Therapeutics. Pharmacology, anti-inflammatory
Abstract

Context: More than 500 Centaurea species compose the Asteraceae family, and most of the recent studies made on the species of this genus proved their pharmacological potential, especially to treat chronic illnesses. Aims: To evaluate for the first time the antioxidant, anti-inflammatory, neuroprotective and anti-microbial properties of the n-butanol (n-BuOH) and ethyl acetate (EA) extracts of the aerial part of Centaurea tougourensis. Methods: The antioxidant activity was determined by ABTS, galvinoxyl radical, phenanthroline, and reducing power assays, while the anti-inflammatory effects were assessed by heat-induced hemolysis and egg albumin denaturation assays. The neuroprotective activity was assessed against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) and the anti-microbial activity by the agar disk diffusion method. Results: Both extracts possess a great antioxidant capacity, but it was considered higher in the n-BuOH extract with respective IC50 values of 8.04 ± 0.21 μg/mL in ABTS assay and 4.25 ± 0.6 μg/mL in GOR assay, while the A0.50 values were 4.46 ± 0.55 μg/mL in phenanthroline assay and 11.16 ± 0.64 μg/mL in reducing power assay. The n-BuOH extract also showed a remarkable anti-inflammatory activity with an EC50 of 120.81 ± 0.2 μg/mL in egg albumin denaturation assay and 154.15 ± 0.14 μg/mL in heat-induced hemolysis assay. The neuroprotective activity of the n-BuOH extract was very strong in both AChE and BChE inhibitory assays with respective IC50 values of 9.8 ± 0.62 μg/mL and 173.53 ± 0.04 μg/mL. EA extract was more active on microbial strains. Conclusions: These encouraging results showed once again the pharmacological potential of Centaurea species.

Published
2021

16. List of contributors

Author

Abbasi, Saad Hanif, Abdel-Mottaleb, Mona M.A., Alaimo, Agustina, Aribisala, Jamiu Olaseni, Aruwa, Christiana Eleojo, Bensaad, Mohamed Sabri, Bravo, Sofía C., Bruno, Sebastián Gabriel, da Silva, Aline Priscilla Gomes, Dassamiour, Saliha, Dean, Oliver John, Diaconeasa, Zorita, Dretcanu, Georgiana, El-Nashar, Heba A.S., El-Shazly, Mohamed, Enaru, Bianca, Figueirinha, Artur, Freije García, Fabricio E., García Liñares, Guadalupe, Ghebache, Widad, Goel, Nidhi, Gonçalves, Ana C., Jharimune, Preeti, Kumar, Naresh, Lopes, Maria, Matos, Patrícia, Mostafa, Nada M., Nematallah, Khaled A., Pedreiro, Sónia, Pérez, Oscar Edgardo, Plessas, Stavros, Pop, Daria T., Queiroz, Marcelo, Ramos, Fernando, Rodrigues, Alexsandra Pereira, Rodrigues, Sofia, Sabiu, Saheed, Samaniego López, Cecilia, Sena, Cristina M., Sganzerla, William Gustavo, Silva, Ana Sanches, Silva, Luís R., Silva Nieto, Ramón, Simal-Gandara, Jesus, Singh, Kanishk, Swilam, Noha, Tutun, Hidayet, Ullah, Aman, and Yipel, Mustafa

Published
2024
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17. Evidence of anti-inflammatory and anti-ulcer properties of aerial parts of Centaurea tougourensis Boiss. and Reut.

Author

Bensaad, Mohamed Sabri, Dassamiour, Saliha, Hambaba, Leila, Kahoul, Mohamed Amine, and Benhoula, Mohammed

Subjects
*CENTAUREA, *CARRAGEENANS, *LABORATORY mice, *TANNINS, *GALLIC acid, *THERAPEUTICS
Abstract

Purpose: To determine the anti-inflammatory and anti-ulcer properties of the aerial parts of Centaurea tougourensis Boiss. & Reut. Methods: The effects of n-butanol (n-BuOH) extract of the aerial part of Centaurea tougourensis on carrageenan-induced paw edema and ethanol-induced gastric mucosal damage were determined at 2 doses (200 and 400 mg/kg, po) in a mouse model. For each test, the animals were randomly divided into negative and positive control groups, as well as extract-treated groups. The mice were observed for any sign of inflammation for a period of 24h. Results: Reduction of paw edema by C. tougourensis extract was highly significant (p < 0.001) at a dose of 400 mg/kg 24 h after carrageenan injection, with 55.26 % inhibition, followed very closely by 53.15 % inhibition at the dose of 200 mg/kg; indomethacin group showed an inhibition of 60 %. Histological examination supported the inhibition results. A significant reduction in inflammation by the extract at a dose of 400 mg/kg was also observed. No sign of ulcer was observed with C. tougourensis at the two doses (200 and 400 mg/kg). The total polyphenol content of the n-BuOH extract was 85.44 цg gallic acid equivalent/mg of extract. Tannins were the most abundant fraction (51.87 цg tannic acid equivalent/mg of extract), followed by flavonoids (25.55 цg quercetin equivalent/mg of extract). Conclusion: The results indicate that C. tougourensis may have potential beneficial effects in the treatment of diseases associated with inflammation and pain, besides its protective effect on the gastrointestinal tract. [ABSTRACT FROM AUTHOR]

Published
2021
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18. General overview on SARS-CoV-2 and potential role of natural compounds as antiviral drugs targeting SARS-CoV-2 proteins.

Author

Dassamiour, Saliha, Ghebache, Widad, and Gharbi, Hala

Subjects
COVID-19 treatment, VIRAL proteins, ANTIVIRAL agents, MEDICATION safety, DRUG efficacy
Abstract

Copyright of Arab Gulf Journal of Scientific Research is the property of Arabian Gulf University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2021

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