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PurposeThis cross-sectional study investigates the utility of the quantitative ultrashort echo time (UTE) adiabatic T1ρ (UTE-Adiab-T1ρ) magnetic resonance imaging (MRI) in detecting potential differences in Achilles tendons and entheses of patients with psoriatic arthritis disease (PsA) compared with asymptomatic volunteers.Material and methodThe Achilles tendons of forty-four PsA patients (59 ± 15 years old, 38 % female) and thirty-seven asymptomatic volunteers (32 ± 10 years old, 51 % female) were scanned on a 3 T clinical scanner in the sagittal plane using a 3-inch surface coil. The 3D UTE-Adiab-T1ρ sequences with fat saturation (FS) were used to measure UTE-Adiab-T1ρ. Tenderness of the tendons, the SF-12 health survey, and visual analog scale (VAS) were recorded for the patients. The Kruskal Wallis test was used to examine the differences in UTE-Adiab-T1ρ values between asymptomatic volunteers and patients, as well as subgroups of patients with pain in the Achilles tendon region and those treated with Biologics. Spearman's correlation coefficients were calculated between UTE-Adiab-T1ρ and patient evaluations. P values

Introduction: Major depressive disorder (MDD) is a mental disorder characterized by alterations in mood, cognition, neurovegetative functions, and psychomotor activity. Millions of people worldwide suffer from this disease. There is no diagnosis based on laboratory tests for major depression. Even though there are varieties of treatments for MDD, antidepressants (ADs) are often used to treat the patients. There is a wide range of different responses to AD drugs. Treatment-resistant depression is a significant challenge in the treatment of this disease. This research aims to review our current knowledge of MDD and show the shortcomings in diagnosing and treating this disease. These gaps display the need for molecular studies to find new biomarkers related to this disease. Methods: This review uses two search strategies: A literature search using keywords (major depressive disorder or MDD) and articles on each study topic. Animal experiments, pediatric MDD, and postpartum depression are excluded. For parts requiring more study, specific keywords were used. Results: Biological approaches can help with a better understanding of the MDD pathogenesis mechanism, which is needed for diagnosis, treatment, and prediction of treatment response. Conclusion: Although various treatments and diagnostic procedures exist for MDD, they are insufficient, and more investigations and research are needed. Finding a specific and sensitive panel of biomarkers is more helpful for accelerating the clinical development of new diagnoses and therapeutics for MDD. [ABSTRACT FROM AUTHOR]

Introduction: The coronavirus disease 2019 (COVID-19) pandemic has posed a major challenge to the diagnosis and management of ischemic heart disease (IHD). Myocardial perfusion imaging (MPI) is a non-invasive technique that can assess myocardial ischemia and viability, as well as provide prognostic information for patients with IHD. However, the role of MPI in COVID-19 patients is not well established. Methods: A comprehensive search of PubMed, Embase, Cochrane Library, and Web of Science was conducted to identify relevant studies published until Aprile 24th, 2024. The inclusion criteria were: (1) studies that performed MPI in COVID- 19 patients; (2) studies that reported the results of MPI in terms of ischemia, infarction, or perfusion defects; and (3) studies that compared MPI with other diagnostic modalities or clinical outcomes. The quality of the studies was assessed using the QUADAS-2 tool for diagnostic accuracy studies or the ROBIS tool for systematic reviews. A narrative synthesis was performed to summarize the main findings and recommendations. Results: A total of twenty-two studies met the inclusion criteria. The included study information was categorized into the following aspects: Change in the crude number of MPI scans performed, accidental and definite findings in MPI, and the prognostic outcome of COVID patients who underwent MPI. Conclusion: During Covid-19 pandemic, a reduction in the number of MPI studies was seen. Individuals with a history of COVID-19 infection have higher likelihood of developing ischemic heart disease (IHD). SARS-CoV-2 is an independent risk factor for the development of IHD. [ABSTRACT FROM AUTHOR]

Idiopathic Thrombocytopenic Purpura (ITP) is a multifactorial disease with decreased count of platelet that can lead to bruising and bleeding manifestations. This study was intended to identify critical genes associated with chronic ITP. The gene expression profile GSE46922 was downloaded from the Gene Expression Omnibus database to recognize Differentially Expressed Genes (DEGs) by R software. Gene ontology and pathway analyses were performed by DAVID. The biological network was constructed using the Cytoscape. Molecular Complex Detection (MCODE) was applied for detecting module analysis. Transcription factors were identified by the PANTHER classification system database and the gene regulatory network was constructed by Cytoscape. One hundred thirty-two DEGs were screened from comparison newly diagnosed ITP than chronic ITP. Biological process analysis revealed that the DEGs were enriched in terms of positive regulation of autophagy and prohibiting apoptosis in the chronic phase. KEGG pathway analysis showed that the DEGs were enriched in the ErbB signaling pathway, mRNA surveillance pathway, Estrogen signaling pathway, and Notch signaling pathway. Additionally, the biological network was established, and five modules were extracted from the network. ARRB1, VIM, SF1, BUB3, GRK5, and RHOG were detected as hub genes that also belonged to the modules. SF1 also was identified as a hub-TF gene. To sum up, microarray data analysis could perform a panel of genes that provides new clues for diagnosing chronic ITP. [ABSTRACT FROM AUTHOR]

Primary bone lymphoma is a rare entity that constitutes less than 1% of all non-Hodgkin lymphomas and 3-5% of malignant bone tumors. Chronic immune and inflammatory diseases carry a level of risk for the development of malignancies that is correlated with the disease severity. There is conflicting evidence regarding the risk of lymphoma in spondyloarthritis., Case Presentation: The authors present a rare case of primary diffuse large B-cell lymphoma of the sternum in a 41-year-old Iranian woman with ankylosing spondylitis (AS). Physical examination revealed a 7×7.5 cm firm swelling of the anterior midline chest wall above the breasts, and MRI showed a lesion within the sternal marrow with an associated soft-tissue mass in the anterior aspect of the sternum. Following core-needle biopsy under ultrasound guidance, a histopathological study demonstrated diffuse sheets of large noncleaved atypical cells with large multilobated prominent nuclei and fine chromatin compatible with diffuse large B-cell lymphoma., Clinical Discussion: Primary and exclusive involvement of the sternum is an uncommon presentation of lymphoma. Radiological, histological, and clinical characteristics of primary bone lymphoma can resemble those of other medical disorders. Although infrequent, existing evidence shows that AS seems to be associated with a small but significant risk for malignancy., Conclusion: Even though inflammatory involvement of the anterior chest wall could be a common clinical finding in patients with AS, it is recommended that anterior chest wall pain or any mass almost always needs comprehensive assessment and imaging evaluation in such patients to avoid any delayed diagnosis, misdiagnosis, and ensuing morbidity or mortality., Competing Interests: All authors declare they have no conflict of interest in any form., (Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.)