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49 results on '"Das, Mrigendra"'

26. Psychotropic prescribing in seriously violent men with schizophrenia or personality disorder in a UK high security hospital

Author

Stone-Brown, Keir, primary, Naji, Mahmood, additional, Francioni, Alex, additional, Myers, Kyle, additional, Samarendra, Harsh, additional, Mushtaq-Chaudhry, Haseeb, additional, Heslop, Stephen, additional, Sengupta, Samrat, additional, Ross, Callum C., additional, Larkin, Fintan, additional, and Das, Mrigendra, additional

Published
2016
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28. The successful concurrent use of two long-acting depot antipsychotics in a patient with treatment-resistant schizophrenia and history of serious violence: a case report.

Author

Lenardon , Anna, Ahmed, Mona, Harfield, Katie-Lynn, Das, Mrigendra, and Lenardon, Anna

Subjects
ANTIPSYCHOTIC agents, SCHIZOPHRENIA, VIOLENCE, PSYCHIATRIC rating scales, AGGRESSION (Psychology)
Abstract

Objective: This case report describes a forensic psychiatric patient presenting with treatment-resistant schizophrenia and serious interpersonal violence complicated by poor adherence to oral medication who was treated successfully with two concurrent long-acting depot antipsychotics.Method: Treatment response was measured for a 6-month period at 6-weekly intervals, post-initiation using the Positive and Negative Symptoms of Schizophrenia with Excited Component score (PANSS-EC), Brief Psychiatric Rating Scale (BPRS) and Clinical Global Impression Scale (CGI).Results: At 6 months, the presentation was found to have markedly improved. The overall PANSS-EC score was reduced by 43.9%, with reductions in Positive Symptom and Excited Component subscales most evident. BPRS Score was reduced from 81 at baseline to 47 at 18 weeks. There was improvement in the patient's level of cooperativeness, aggression and engagement in ward therapeutic activities.Conclusion: Although concurrent use of two depot antipsychotics requires further exploration, there is potential benefit for patient groups presenting with treatment-resistant schizophrenia and poor compliance. Due to risk of serious adverse effects which are difficult to reverse with long-acting formulations, we recommend this option be reserved for this complex patient population and exclusively in care settings allowing close physical health monitoring. [ABSTRACT FROM AUTHOR]

Published
2017
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29. Effectiveness of a single day induction programme in changing medical students' attitudes towards the speciality of forensic psychiatry.

Author

Archer, Ann, Guliani, Joshana, Johns, Francesca, McCartney, Emily, Smith, E. Naomi, Ross, Callum C., Sengupta, Samrat, and Das, Mrigendra

Subjects
FORENSIC psychiatry, FORENSIC psychology, FORENSIC medicine, MEDICAL students, PATHOLOGICAL psychology, ATTITUDE (Psychology), MEDICAL personnel, PSYCHOLOGY of medical students, PSYCHIATRIC hospitals, VOCATIONAL guidance
Abstract

Objectives: We aimed to investigate the effectiveness of a day visit in changing attitudes towards a high-security forensic psychiatric hospital, with regard to the current recruitment difficulties in psychiatry.Methods: Broadmoor Hospital, a UK high-security psychiatric hospital, runs day visits for medical students, led by doctors. At the beginning and the end of the day students wrote their responses to the question, 'What do you think of Broadmoor?' Attitudes and themes were identified, and their prevalence was analysed.Results: The responses of 296 students were initially analysed; however, 19 responses had to be excluded because they were illegible or incomplete. Before the visit, 15 responses were rated as positive, 169 neutral and 93 negative. After the visit, 205 responses were positive, 69 neutral and three negative. The themes that changed markedly following the visit were those indicating a change to favourable attitude.Conclusions: A single day visit was shown to be effective in altering the attitudes of medical students towards forensic psychiatry within a high-security psychiatric hospital. [ABSTRACT FROM AUTHOR]

Published
2017
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40. Effects of Procyclidine on Eye Movements in Schizophrenia

Author

Ettinger, Ulrich, primary, Kumari, Veena, additional, Zachariah, Elizabeth, additional, Galea, Adrian, additional, Crawford, Trevor J, additional, Corr, Philip J, additional, Taylor, David, additional, Das, Mrigendra, additional, and Sharma, Tonmoy, additional

Published
2003
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44. Cognitive effects of nicotine in man: A functional MRI investigation

Author

Kumari, Veena, primary, Gray, Jeffrey, additional, ffytchet, Dominic, additional, Mitterschiffthaler, Martina, additional, Das, Mrigendra, additional, Zachariah, Elizabeth, additional, Vythelingum, Goparlen, additional, Williams, Steven, additional, Coppola, Richard, additional, Goldberg, Terry, additional, and Sharma, Tonmoy, additional

Published
2001
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46. Lower anterior cingulate volume in seriously violent men with antisocial personality disorder or schizophrenia and a history of childhood abuse.

Author

Kumari, Veena, Uddin, Shahir, Premkumar, Preethi, Young, Susan, Gudjonsson, Gisli H, Raghuvanshi, Satya, Barkataki, Ian, Sumich, Alexander, Taylor, Pamela, and Das, Mrigendra

Subjects
ANALYSIS of covariance, ANALYSIS of variance, ANTISOCIAL personality disorders, BRAIN, CHILD abuse, FORENSIC psychiatry, MAGNETIC resonance imaging, CLASSIFICATION of mental disorders, PROBABILITY theory, RESEARCH funding, SCHIZOPHRENIA, PSYCHOLOGY of the sick, STATISTICS, VIOLENCE, DATA analysis, DATA analysis software, DESCRIPTIVE statistics
Abstract

The article discusses a study which examined the grey matter volume of the anterior cingulate (AC) in relation to seriously violent behaviour and childhood psychosocial deprivation in the context of a mental disorder. In this study, the subjects underwent whole-brain magnetic resonance imaging and were rated on the presence of serious violence such as physical abuse. It concluded that violent mentally disordered individuals with mental disorder suffer from a significant AC volume loss.

Published
2014
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48. Augmentation of clozapine with amisulpride: an effective therapeutic strategy for violent treatment-resistant schizophrenia patients in a UK high-security hospital

Author

Hotham, James E., Simpson, Patrick J. D., Brooman-White, Rosalie S., Basu, Amlan, Ross, Callum C., Humphreys, Sharon A., Larkin, Fintan, Gupta, Nitin, and Das, Mrigendra

Abstract

ObjectiveClozapine is used in the management of treatment-resistant schizophrenia and is effective in reducing aggression; however a subgroup of patients is poorly responsive. For violent patients in this group, there is limited literature on the use of strategies to augment clozapine with other agents. Here we present a case series of 6 schizophrenia patients, within a high-security hospital, who have a history of serious violence and who were treated with clozapine augmented with amisulpride.MethodsWe reviewed case notes and health records for evidence of violence/aggression and positive factors such as engagement in activities, and Clinical Global Impression (CGI) scores were formulated. We also examined metabolic parameters before and after augmentation.ResultsAll 6 of the patients showed clinical improvement in symptoms and a reduction in their risk of violence to others. Five patients had a reduction in number of violent/aggressive incidents, and all patients showed improvement in engagement in occupational, vocational, and/or psychological work. Metabolic parameters were largely unchanged except for 1 patient whose Body Mass Index (BMI) increased. Five patients reported side effects as unchanged or improved.ConclusionThese schizophrenia patients with a history of violence showed clinical improvement and reduced aggression and violence with amisulpride augmentation of clozapine. To our knowledge, this is the first report of an antiaggressive benefit of this combination in forensic psychiatric patients. Further studies are warranted to establish the efficacy and anti-aggressive effects of amisulpride augmentation of clozapine.

Published
2014
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49. Neuroimaging violence in the mentally ill: what can it tell us?

Author

Das, Mrigendra, Kumari, Veena, Barkataki, Ian, and Sharma, Tonmoy

Abstract

Incidents of aggression and violence in severe mental disorders like psychosis, personality disorders and substance misuse disorders are higher than in the general population. Recent advances in neuroimaging techniques may help to predict violent behaviour in mentally ill individuals and to identify anomalies in brain functioning that may be amenable to treatment.

Published
2002
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