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6. Draft Genome of the Liver Fluke Fasciola gigantica

Author

Pandey, Tripti, primary, Ghosh, Arpita, additional, Todur, Vivek N., additional, Rajendran, Vijayakumar, additional, Kalita, Parismita, additional, Kalita, Jupitara, additional, Shukla, Rohit, additional, Chetri, Purna B., additional, Shukla, Harish, additional, Sonkar, Amit, additional, Lyngdoh, Denzelle Lee, additional, Singh, Radhika, additional, Khan, Heena, additional, Nongkhlaw, Joplin, additional, Das, Kanhu Charan, additional, and Tripathi, Timir, additional

Published
2020
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9. Genome-wide identification and characterization of eukaryotic protein kinases.

Author

Das KC, Kalita P, and Tripathi T

Subjects
Animals, Computational Biology methods, Fasciola enzymology, Fasciola physiology, Fascioliasis parasitology, Helminth Proteins classification, Helminth Proteins metabolism, Humans, Isoenzymes classification, Isoenzymes genetics, Isoenzymes metabolism, Multigene Family genetics, Phosphorylation, Phylogeny, Protein Kinases classification, Protein Kinases metabolism, Eukaryotic Cells enzymology, Fasciola genetics, Genome, Helminth genetics, Genome-Wide Association Study methods, Helminth Proteins genetics, Protein Kinases genetics
Abstract

The tropical liver fluke,  Fasciola gigantica  is a food-borne parasite responsible for the hepatobiliary disease fascioliasis. The recent completion of  F. gigantica  genome sequencing by our group has provided a platform for the systematic analysis of the parasite genome. Eukaryotic protein kinases (ePKs) are regulators of cellular phosphorylation. In the present study, we used various computational and bioinformatics tools to extensively analyse the ePKs in  F. gigantica ( FgePKs) genome. A total of 455 ePKs were identified that represent ~2% of the parasite genome. Out of these, 214 ePKs are typical kinases (Ser/Thr- and Tyr-specific ePKs), and 241 were other kinases. Several FgePKs were found to possess unusual domain architectures, which suggests the diverse nature of the proteins that can be exploited for designing novel inhibitors. 115 kinases showed <35% query coverage when compared to human ePKs highlighting significant divergences in their respective kinomes, further providing a platform for novel structure-based drug designing. This study provides a platform that may open new avenues into our understanding of helminth biochemistry and drug discovery.

Published
2020
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