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Cypate-octreote peptide analogue conjugate (Cytate) was investigated as a prostate cancer receptor-targeted contrast agent. The absorption and fluorescence spectra of Cytate were ranged in the near-infrared 'tissue optical window.' Time-resolved investigation of polarization-dependent fluorescence emitted from Cytate in solution as well as in cancerous and normal prostate tissues was conducted. Polarization preservation characteristics of Cytate in solution and tissues were studied. Fluorescence intensity emitted from the Cytate-stained cancerous prostate tissue was round to be much stronger than that from the Cytate-stained normal prostate tissue, indicating more Cytate uptake in the former tissue type. The polarization anisotropy of Cytate contained in cancerous prostate tissue was found to be larger than that in the normal prostate tissue, indicating a larger degree of polarization preservation in Cytate-stained cancerous tissue. The temporal profiles of fluorescence from Cytate solution and from Cytate-stained prostate tissue were fitted using a time-dependent fluorescence depolarization model. The photoluminescence imaging of Cytate-stained cancerous and normal prostate tissues was accomplished, showing the potential of Cytate as a fluorescence marker for prostate cancer detection. OCIS codes: 300.6280, 110.3080.

Byline: B. B. Das (1), S. Sahoo (2), D. D. Ivy (1) Keywords: Neonatal aortic arch thrombosis Abstract: We report two neonates with thrombosis of the aortic arch and isthmus diagnosed by echocardiography. Neonatal transient protein C deficiency was present in one patient and the other patient had severe perinatal asphyxia. Both patients presented with markedly reduced left ventricular function and severe aortic obstruction. In one infant, the thrombus was successfully removed surgically, and the second infant died due to serious complications of perinatal asphyxia. Author Affiliation: (1) Department of Pediatrics, Section of Cardiology, The Children's Hospital, University of Colorado Health Science Center, 1056 East 19th Avenue, Denver, CO 80218, USA (2) Department of Pathology, University of Chicago, Chicago, IL 60637, USA Article History: Registration Date: 01/01/2003 Online Date: 03/11/2003

The image of an object hidden in highly scattering media was reconstructed using a fast, noise-resistant algorithm newly applied to diffusion tomography. A pulsed light source producing scattered and transmitted light is examined at multiple times. Multiple source detector pairs around the medium are used to obtain data in many different directions. An inverse scattering algorithm with nonuniform regularization achieves rapid inversion convergence.

The optical density of breast tissues without blood is found to be relatively constant from 320 to 800 nm, indicating a relatively independent scattering cross section over this wavelength region.

Byline: B. B. Das (1), J. Sharma (2) Keywords: QTc dispersion; JTc dispersion; Ventricular ectopy; Ventricular repolarization abnormality Abstract: In adults, increased QT dispersion has been shown to predict arrhythmic risk as well as risk of sudden death in several clinical settings. It is controversial whether QT and JT dispersion are increased in children with ventricular ectopy and a structurally normal heart. We studied two groups of children: 25 patients with ventricular ectopy and 25 healthy children as controls. Standard electrocardiograms were reviewed and dispersions of both corrected QT (QTc) and JT (JTc) intervals were compared. We conclude that QTc and JTc dispersions are significantly increased in children with ventricular ectopy compared to control subjects. Author Affiliation: (1) Department of Pediatric Cardiology, The Children's Hospital, University of Colorado Health Sciences Center, Denver, CO 80218, USA (2) Division of Pediatric Cardiology, Children Hospital at Downstate, State University of New York, Brooklyn, NY 11203, USA Article History: Registration Date: 01/01/2003 Online Date: 23/01/2004 Article note: This paper was presented as a poster at APS-SPR 2001, Baltimore.

Temperature-dependent time-resolved photoluminescence spectroscopy is used to investigate the carrier recombination through radiative and nonradiative processes in lattice-matched ZnCdSe/ZnCdMgSe multi-quantum-wells (MQWs). The carrier recombination processes found in these samples are attributed to the interplay between the free carrier recombination and hole capture through multiphonon emission.