746 results on '"Darya, S."'
Search Results
2. An association between the blood perfusion parameters in foot tissues and the severity of arterial occlusion and stenosis in the lower extremities
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Ksenia A. Krasulina, Polina A. Glazkova, Alexey A. Glazkov, Darya S. Selivanova, Sergei S. Zagarov, Akhmed V. Vataev, Roman N. Larkov, and Dmitry A. Rogatkin
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peripheral artery disease ,skin ,microcirculation ,incoherent optical fluctuation flowmetry ,Medicine - Abstract
Rationale: Peripheral artery disease (PAD) is common among the elderly and increases the risk of cardiovascular events, disability and death. PAD course and outcomes depend not only on the condition of macrovasculature but also on the tissue perfusion. We have previously shown that Type 2 diabetic patients with lower extremity ischemia have significantly lower perfusion than healthy volunteers, and the ratio of basal perfusion in the arm and leg (BP1/BP3) measured by incoherent optical fluctuation flowmetry (IOFF) allows to identify hemodynamically significant stenoses. Aim: To analyze associations between perfusion parameters registered by IOFF and the severity of vascular involvement in PAD patients. Methods: This single center cross-sectional study included 38 PAD patients admitted to the Department of Vascular Surgery and Coronary Artery Disease. The arteries were assessed with duplex Doppler ultrasonography (DDU), according to the results of which the PAD severity score and ankle-brachial index (ABI) were calculated. Skin microhemodynamic parameters were recorded by IOFF. The basal perfusion on the arm (BP1), the dorsal foot surface and the toe (BP2 and BP3), the ratio BP1/BP3, local thermal hyperemia (LTH2 and LTH3) and an increase in perfusion after heating on two leg zones (LTH2-BP2, LTH3-BP3) were evaluated and expressed in perfusion units (PU). BP1, BP3, and BP1/BP3 values were additionally measured with laser Doppler flowmetry (LDF). The analysis was performed depending on the degree of arterial involvement determined by DDU for each limb separately (n = 73). There were ≥ 50% stenoses in 15 extremities (Group 1), occlusion of one of the major arteries in 42 (Group 2) and ≥ 2 occlusions in 16 lower extremities (Group 3). Results: In the groups 1, 2 and 3, the values of most parameters estimated by IOFF decreased with an increase in severity of limb lesions. As an example, the respective perfusion parameters for the big toe in the study groups were as follows: BP3 4.0 [2.0; 9.8], 2.2 [0.9; 3.7] and 1.1 [0.7; 2.6] PU (p = 0.007); LTH3 10.0 [6.4; 14.9], 5.0 [1.5; 7.8] and 2.5 [1.4; 4.5] PU (p 0.001), and LTH3-BP3 3.8 [2.6; 7.8], 2.4 [0.6; 4.3] and 1.2 [0.4; 1.5] PU (p = 0.001). The BP1/BP3 ratio in the above mentioned group increased: 1.8 [0.8; 7.7], 7.2 [3.4; 21.3] and 14.2 [6.6; 18.3] (p = 0.004), respectively. No similar trend was found for this parameter registered by LDF. There were significant correlations between the lower extremities perfusion parameters measured by IOFF and ABI, with the correlation coefficients ranging from 0.365 to 0.717 (p 0.05). Conclusion: The functional parameters of the skin microhemodynamics vary with different PAD severity. In addition, they correlate with clinical indicators of atherosclerosis. The IOFF technique can be promising as an additional quantitative method for assessment of microvascular blood flow in patients with PAD.
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- 2024
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3. Revision of the genus Kunungua (Hemiptera, Heteroptera, Miridae) with descriptions of three new species and new generic synonymy
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Darya S. Bolshakova and Fedor V. Konstantinov
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Biology (General) ,QH301-705.5 - Abstract
This study provides a taxonomic revision of the genus Kunungua Carvalho, 1951 (Hemiptera, Heteroptera, Miridae, Bryocorinae, Eccritotarsini) with the description of three new species, K. atramentomaculata sp. nov., K. gemina sp. nov., and K. ornata sp. nov. Revised diagnoses for the genus and three additional species are given, along with a key to the species. Habitus photographs, illustrations of male genitalic structures, and distributional information are provided for each species. The placement of Kunungua within the Prodromus group of genera is discussed. The genus Duducoris Odhiambo, 1962 is recognised as a new junior subjective synonym of Prodromus Distant, 1904, resulting in new combinations for the five species contained in the subsumed genus. Kunungua pallida Linnavuori, 1975 is excluded from the genus Kunungua and treated as a species of uncertain generic placement.
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- 2024
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4. Hexagonal BN/Methylene Blue Heterostructures for Local Photodynamic Therapy of Melanoma
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Kalugina, Darya S., Matveev, Andrei T., Timoshenko, Roman V., Erofeev, Alexander S., Kutzhanov, Magzhan K., Kotyakova, Kristina Yu., Chikileva, Irina O., Fedorova, Polina O., and Shtansky, Dmitry V.
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- 2024
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5. Bis((9H-(4,5-diazafluoren)-9-ylidene)methyl)arylenes: Design, synthesis, optoelectronic properties, sensorics and luminescent coordination polymers
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Cheshkina, Darya S., Becker, Christina S., Sonina, Alina A., Koskin, Igor P., Shundrina, Inna K., and Kazantsev, Maxim S.
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- 2024
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6. URANYL IODOACETATES OF MAGNESIUM, MANGANESE AND NICKEL
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Serezhkin, Viktor N., Grigoriev, Mikhail S., Mitina, Darya S., Savchenkov, Anton V., and Serezhkina, Larisa B.
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- 2024
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7. INCREASING THE EFFICIENCY OF USING WOOD BIOMASS BY PROVIDING SPECIAL PROPERTIES
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Mikhail A. Zyryanov, Sergey O. Medvedev, Alexey A. Kukushkin, Ilya S. Ponomarev, Natalya A. Gavrilova, Darya S. Volkova, and Evgeny V. Root
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pyrazole ,nitrosopyrazole ,acidity constant ,polyfluorinated pyrazoles ,diketone oximes ,polyfluorinated diketones ,Agriculture ,Science - Abstract
Background. The search for ways to use logging waste is a distinct scientific direction, due to the large number of their permanent formation. The importance of such studies is associated with the need to reduce the loss of valuable wood raw materials in the form of logging waste. One of the possible ways of using waste from logging industries is the production of wood chips using a mobile complex of machines with its further recycling into a wood-fiber semi-finished product. Wood-fiber semi-finished product is, as it is known nowadays, one of the environmentally friendly types of insulation and finishing materials. A significant limitation in the use of wood fiber in various types of production is low fire and bio-resistance. As a consequence, imparting specific properties to a wood-fiber semi-finished product in the form of fire and bio-resistance is an acute problem of the modern wood processing industry. Purpose. Synthesis of 4-azofunctionalized pyrazoles with perfluoroalkyl substituent by cyclocondensation of polyfluorinated beta-diketones to confer special properties to the wood-fiber semi-finished product. Materials and methods. The 1H, 13C NMR and 1H-13C HSQC spectra were registered at the Krasnoyarsk Regional Center for Collective Use of the FITC KNC SB RAS on a Bruker Avance III Fourier spectrometer with a frequency of 600 MHz equipped with sensitive helium probes with a diameter of 5 mm and 1.7 mm. TMS is used as an internal standard. Chromato-mass spectra were obtained using ISQ 7610 Single Quadrupole GC-MS and Shimadzu LC/MS-2020 instruments. Methyl alcohol was used as the mobile phase. IR spectra were recorded on the FT-801 (FT-801) SIMEX IR Fourier spectrometer with a spectral range from 450 to 5700 cm-1. UV spectra were recorded on a HELIOS OMEGA spectrophotometer equipped with a tungsten-halogen lamp in quartz cuvettes with a diameter of 1 cm at a concentration of 1·10-4 mol/l for 200-400 nm and a concentration of 1·10-2 mol/l for 400-800 nm in ethanol. Melting temperatures were determined in open capillaries on a PTP device (TU 25-11-1144-76). Results. 3 new compounds were synthesized: 3(5)-(thiophene-2-yl)-4-nitroso-5(3)-(trifluoromethyl)-1H-pyrazole, 3(5)-phenyl-4-nitroso-5(3)-(trifluoromethyl)-1H-pyrazole and 3(5)-(naphthalene-2-yl)-4-nitroso-5(3)-(trifluoromethyl)-1H-pyrazole. Conclusion. Thus, 3(5)-(thiophene-2-yl)-4-nitroso-5(3)-(trifluoromethyl)-1H-pyrazole, 3(5)-phenyl-4-nitroso-5(3)-(trifluoromethyl)-1H-pyrazole and 3(5)-(naphthalene-2-yl)-4-nitroso-5(3)-(trifluoromethyl)-1H-pyrazole. Complex separable mixtures of substances containing pyrazoline, β-diketone and target nitrosopyrazoles were formed by a single-reactor method. The two-stage method of production proposed by us increases the purity and yield of the target products.
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- 2023
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8. FREQUENCY OF ANXIETY DISORDERS IN PATIENTS WITH ARTERIAL HYPERTENSION AND COMORBID DISEASES
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Elena A. Pronina, Natalya Yu. Shimokhina, Darya S. Kaskaeva, Lyudmila K. Danilova, Olga V. Tutinina, Svetlana Yu. Shtarik, and Мarina М. Petrova
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anxiety ,arterial hypertension ,obesity ,diabetes mellitus type 2 ,Education (General) ,L7-991 ,Psychology ,BF1-990 - Abstract
Background. Anxiety is more common in patients with hypertension. The comorbid presence anxiety disorders and arterial hypertension complicates medical treatment, may change the severity and/or progression of disease. Objective. To study the influence of comorbid diseases on the development of anxiety disorders in patients with hypertension in outpatient practice. Methods. This observational cohort study employed the State‐Trait Anxiety Inventory (STAI, Spielberger anxiety scale) to assess symptoms of anxiety in several groups with hypertension. The study cohort included 360 patients with isolated hypertension, 172 patients with hypertension in combination with obesity and 72 patients with comorbid hypertension and type 2 diabetes mellitus (DM) Results. A high incidence of anxiety disorders was found in patients with hypertension 98.06% regardless of the presence of obesity 97.09% and type 2 diabetes 98.18%. The incidence and severity of trait anxiety in the examined patients was the lowest in the group of patients with hypertension in combination with obesity 59.65%, compared with patients with isolated hypertension 68.61% p =0.042045 and the group of hypertension in combination with type 2 diabetes 78.18% p=0.012662. According to the severity of the combination of hypertension with obesity, patients with a low 40.35% and an average 41.52% indicator of trait anxiety prevailed, in patients with hypertension in combination with type 2 diabetes, an average 52.73% and a high 25.45% level of anxiety were more often observed (p
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- 2023
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9. Mycelium architecture: current state and development prospects
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Solomina Darya S. and Mordvov Arkadiy A.
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biotechnology in architecture ,architectural biocomposite materials ,bio-architecture ,Architecture ,NA1-9428 - Abstract
The article reviews current experiences in the integration of mycelium-based biotechnologies into architecture. Key developments in this area are considered. Projects using mycelial structures are assessed by the criteria of construction geometry and methods of implementation. A comparative analysis is used to re-trace the chronology and identify the main trends in the development of architecture that uses mycelium structures today.
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- 2024
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10. Hydrolyzed marine collagen in complex therapy of degenerative-dystrophic changes in the mustocular system
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Dmitry I. Trukhan and Darya S. Ivanova
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degenerative-dystrophic changes in the musculoskeletal system ,osteoarthritis ,treatment ,prevention ,collagen ,promerim® hydrolylated marine collagen ,vitamin c ,vitamin d3 ,zinc ,calcium ,Internal medicine ,RC31-1245 - Abstract
Degenerative-dystrophic changes in the musculoskeletal system of various localizations are one of the most common reasons for patients to turn not only to a rheumatologist, but also to a neurologist and first-contact doctors (therapist and general practitioner) who provide primary health care. Medicines that modify the symptoms of degenerative-dystrophic changes in the musculoskeletal system are divided into “fast-acting” (analgesics, NSAIDs, tramadol) and “slow-acting” (chondroprotectors). When considering “slow-acting” drugs, many publications are devoted to the natural components of the cartilage intercellular substance – glucosamine and chondroitin sulfate, while much less attention is paid to the importance of collagen. In articular cartilage, collagens provide most of the biomechanical properties of the extracellular matrix necessary for its function. Collagen hydrolysates have demonstrated positive results in clinical trials related to joint health, such as reducing joint pain, increasing mobility, and improving joint structure. Marine collagen is the closest in molecular structure to human collagen fibers. Its main characteristics include high biological activity and biocompatibility, as well as low antigenicity. The possible effects of vitamin C, vitamin D3, zinc and calcium in the complex treatment of degenerative-dystrophic changes in the musculoskeletal system are considered. A biological supplement containing vitamins, microelements and hydrolyzed marine collagen Promerim® optimizes the prevention and treatment of patients with degenerative changes in the musculoskeletal system.
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- 2023
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11. Social Media as a Mechanism for Developing and Reproducing Migration Strategies (Using the Example of Digital Platform Profiles of Russian-Speaking Migrants in Korea)
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Dmitry O. Timoshkin, Darya S. Pchelkina, Andrei S. Samarin, Vsevolod V. Khvorostov, and Roman V. Tamilin
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korea ,migration strategies ,social media ,discourse ,mental simulations ,informal economy ,mediation ,k-pop ,Sociology (General) ,HM401-1281 - Abstract
This article analyzes texts written by users of Russian-language digital communication platforms on the topic of emigration to the Republic of Korea. The purpose of the study was to determine what meanings are attributed to the Republic in these texts, and how these images can affect the migration strategies of Russian-speaking migrants. The texts were sourced from relevant communities inside the largest social networks by the number of Russian-speaking users. The research method of choice was discourse analysis. Korea was regarded as an intersectional symbol that combines “migrant” texts into a single discourse. Its significance was determined by means of the authors of the messages constructing associations between the host country and certain situations and actions. It was established that pendulum migrants working in the country illegally, educational migrants, intermediaries, and communities of fans of Korean popular culture are most actively involved in shaping the image of Korea within the considered social media platforms. The messages posted by those users who focus on the shadow segment of the labor market portray Korea as a country that deals with visitors employed in this segment in as lenient a manner as possible. During the visa-free period, you can earn more here than in six months back home, without knowing the language and without having any skills, after which you can go home and return to Korea again once the money you earned has run out. This group describes the following strategy: you enter the country as a tourist for 60 days, and find a job on “samushil” or through an intermediary. Then return to Russia temporarily, or stay in Korea illegally, or use such mechanisms as political asylum and marriage of convenience. Educational migrants describe Korea as a developed, safe and wealthy country, with optimal conditions for permanent residency. Many describe the following strategy: get into the country on a student visa, receive an education, find a job in areas somehow related to servicing Russian-speaking migration flows. Some count on legalization through marriage to a member of the host community. Groups dedicated to Korean popular culture associate the Republic with a male idol, overconsumption, scenery and drama characters. Their users might describe either of the strategies mentioned above. A group of intermediaries reproduces the images conveyed by the texts produced by illegal migrants and k-pop communities, idealizing Korea and omitting the numerous difficulties and risks associated with staying there. Intermediaries essentially provide customers with the opportunity to become a part of this image by selling them paths of migration to and integration in Korea, which are often utilized by pendulum and educational migrants. According to G. Klein’s model of decision-making in a situation of uncertainty, it can be assumed that “migrant” social media containing these images contribute to the dissemination and reproduction of appropriate migration strategies, influencing the direction and content of migration flows between Korea and the CIS countries.
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- 2023
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12. Anti-SMN autoantibodies in mixed connective tissue disease are associated with a severe systemic sclerosis phenotype
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Minoru Satoh, Océane Landon-Cardinal, Alexandra Albert, Sabrina Hoa, Jean-Luc Senecal, Martial Koenig, Josiane Bourré-Tessier, Eric Rich, Jean-Richard Goulet, Yves Troyanov, Hajar El Kamouni, Darya S. Jalaledin, Caroline Vo, Gemma Pérez, May Y. Choi, and Marvin J. Fritzler
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Medicine - Abstract
Objectives The survival of motor neuron (SMN) complex has an essential role in the assembly of small nuclear ribonucleoproteins (RNP). Recent reports have described autoantibodies (aAbs) to the SMN complex as novel biomarkers in anti-U1RNP+ myositis patients. The aim of this study was to compare phenotypic features of anti-U1RNP+ mixed connective tissue disease (MCTD) patients with and without anti-SMN aAbs.Methods A retrospective MCTD cohort was studied. Addressable laser bead immunoassay was used to detect specific anti-SMN aAbs with
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- 2023
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13. Atomic structure and optical properties of color centers of silver in AgAu/glass irradiated by UV laser
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Srabionyan, Vasiliy V., Avakyan, Leon A., Durymanov, Veniamin A., Rubanik, Darya S., Viklenko, Ivan A., Skunova, Anna V., and Bugaev, Lusegen A.
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- 2023
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14. Studying the level of trust in regional authorities
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Darya S. Bents and Irina A. Belova
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regional authority ,region management efficiency ,trust ,educational environment ,higher education system ,national development goals ,Business ,HF5001-6182 ,Finance ,HG1-9999 - Abstract
. The absence or low level of trust in regional authorities hinder the development of the country’s economy. Building trust is a long-term objective and largely depends on the region’s educational environment, especially the university one, which should nurture human resources. The study aims to establish the level of trust in the institutions of higher education, healthcare and regional authorities in the educational environment of Chelyabinsk oblast (Russia). The theory of spatial development, cultural and institutional theories of trust constitute the theoretical framework of the study. The methods of ranging and grouping, as well as correlation analysis were applied. Empirical evidence is obtained through the survey of 382 respondents working in the field of higher education in Chelyabinsk oblast. In the paper, we determine the level of their trust in the institutions of education, healthcare, regional and municipal authorities. Among students, lecturers and other university employees, the highest and the lowest levels of trust were recorded in educational institutions and regional and municipal authorities, respectively. Correlation analysis revealed the relationship between trust and possible factors in its formation within each institution under study. It was found that this relationship was not universal either in the context of respondents’ categories or trust forms. The paper provides recommendations for regional and municipal authorities focused on increasing the confidence in their activities and, as a result, enhancing their effectiveness.
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- 2023
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15. Mathematical Modeling of Dynamic and Optical Effects in Ionospheric Experiments Using an Explosive Chemical Generator
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Stupitsky, Evgeniy L., Motorin, Andrey A., Moiseeva, Darya S., Howlett, Robert J., Series Editor, Jain, Lakhmi C., Series Editor, Favorskaya, Margarita N., editor, Nikitin, Ilia S., editor, and Severina, Natalia S., editor
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- 2022
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16. The mechanism of damage recognition by apurinic/apyrimidinic endonuclease Nfo from Escherichia coli
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Senchurova, Svetlana I., Syryamina, Victoria N., Kuznetsova, Aleksandra A., Novopashina, Darya S., Ishchenko, Alexander A., Saparbaev, Murat, Dzuba, Sergei A., Fedorova, Olga S., and Kuznetsov, Nikita A.
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- 2022
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17. Cognitive functions and patterns of brain activity in patients after simultaneous coronary and carotid artery revascularization
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Irina Tarasova, Olga Trubnikova, Darya S. Kupriyanova, Olga Maleva, Irina Syrova, Irina Kukhareva, Anastasia Sosnina, Roman Tarasov, and Olga Barbarash
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simultaneous revascularization ,coronary artery bypass grafting ,carotid endarterectomy ,postoperative cognitive dysfunction ,brain electrical activity ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
BackgroundOn-pump coronary artery bypass grafting (CABG) is associated with a high risk of neurological complications in patients with severe carotid stenosis. Moreover, early postoperative cognitive dysfunction (POCD) incidence remains high in patients undergoing simultaneous coronary and carotid surgery. Recent studies have shown that even moderate carotid stenosis (≥50%) is associated with postoperative cognitive decline after CABG. Data on brain health in the postoperative period of simultaneous coronary and carotid surgery are limited.ObjectivesThis study aimed to analyze early postoperative changes in the cognitive function and patterns of brain electrical activity in patients after simultaneous coronary and carotid artery revascularization.Materials and methodsBetween January 2017 and December 2020, consecutive patients were assigned to on-pump CABG with or without carotid endarterectomy (CEA) according to clinical indications. An extended neuropsychological and electroencephalographic (EEG) assessment was performed before surgery and at 7–10 days after CABG or CABG + CEA.ResultsA total of 100 patients were included [median age 59 (55; 65), 95% men, MMSE 27 (26; 28)], and among these, 46 underwent CEA. POCD was diagnosed in 29 (63.0%) patients with CABG + CEA and in 32 (59.0%) patients with isolated CABG. All patients presented with a postoperative theta power increase. However, patients with CABG + right-sided CEA demonstrated the most pronounced theta power increase compared to patients with isolated CABG.ConclusionThe findings of our study show that patients with CABG + CEA and isolated CABG have comparable POCD incidence; however, patients with CABG + right-sided CEA presented with lower brain activity.
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- 2023
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18. The significance of upfront autologous stem cell transplantation for high‐intermediate/high‐risk stage IV diffuse large B‐cell lymphoma
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Aleksei K. Koviazin, Larisa V. Filatova, Ilia S. Zyuzgin, Anna S. Artemyeva, Ilia L. Poliatskin, Darya S. Burda, Stanislav A. Volchenkov, Svetlana S. Elkhova, and Tatiana Yu. Semiglazova
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autologous hematopoietic stem cell transplantation ,diffuse large B‐cell lymphoma ,high‐risk ,stage IV ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background Diffuse large B‐cell lymphoma (DLBCL) is the most common (30%–35%) type of B‐cell lymphoma. Only about 60% of all newly diagnosed advanced‐stage DLBCL can be completely treated with x6 R‐CHOP. High‐dose chemotherapy (HDCT) followed by autologous hematopoietic stem cell transplantation in the first remission (upfront auto‐HSCT) can serve as an option to improve a prognosis in these patients. Aims This trial aimed to improve prognosis in DLBCL by upfront auto‐HSCT. Methods and Results A group of 105 patients: DLBCL NOS, age 18–65, stage IV, IPI ≥2, CR/PR after x6 R‐CHOP/DA‐EPOCH‐R from 2010 to 2019 at NMRC of Oncology named after N.N.Petrov of MoH of Russia was retrospectively analyzed. The HSCT group included patients with upfront HDCT followed by auto‐HSCT (n = 35). The control group included patients with non‐invasive follow‐up after induction (n = 70). Primary endpoint was progression‐free survival (PFS). Secondary endpoints were overall survival (OS), response rate and relapse rate. The 3‐year OS (p = .013) and 3‐year PFS (p = .033) were significantly higher in the HSCT group. The 3‐year OS was decreased by the occurrence of relapse (p ≤ .001) and weight loss (B‐symptom) (p = .04). DEL was the negative prognostic factor for 3‐year PFS in all patients (p = .001) and control group (p = .001). DA‐EPOCH‐R significantly increased the 3‐year PFS (p = .041). Conclusion Upfront HDCT followed by auto‐HSCT can increase 3‐year OS and PFS and improve prognosis in DLBCL NOS, age 18–65, stage IV, IPI ≥2 patients.
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- 2023
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19. Vitamin and mineral complexes in prevention, treatment and rehabilitation after acute respiratory viral infections and new coronavirus infection (COVID-19)
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Dmitry I. Trukhan and Darya S. Ivanova
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acute respiratory viral infections ,novel coronavirus infection ,covid-19 ,prevention ,treatment ,rehabilitation ,post-covid syndrome ,chronic fatigue syndrome ,nutraceuticals ,selenium ,zinc ,vitamin a ,vitamin c ,vitamin e ,Internal medicine ,RC31-1245 - Abstract
The presented review considers the issues of non-specific prevention of acute respiratory viral infections, with an emphasis on a new coronavirus infection (COVID-19) using vitamin and mineral complexes. Data are presented on the capabilities of selenium and zinc trace elements, vitamins A, C, E in the prevention and treatment of patients with acute respiratory viral infections and COVID-19 infection. The possible use of vitamin-mineral complexes in the rehabilitation period, with the development of chronic fatigue syndrome as part of the post-COVID syndrome, is discussed.
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- 2022
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20. Kinetic Features of Degradation of R-Loops by RNase H1 from Escherichia coli.
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Kuznetsova, Aleksandra A., Kosarev, Iurii A., Timofeyeva, Nadezhda A., Novopashina, Darya S., and Kuznetsov, Nikita A.
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REPLICATION fork ,RNA polymerases ,ENZYME kinetics ,GENETIC transcription ,RNA analysis - Abstract
R-loops can act as replication fork barriers, creating transcription–replication collisions and inducing replication stress by arresting DNA synthesis, thereby possibly causing aberrant processing and the formation of DNA strand breaks. RNase H1 (RH1) is one of the enzymes that participates in R-loop degradation by cleaving the RNA strand within a hybrid RNA–DNA duplex. In this study, the kinetic features of the interaction of RH1 from Escherichia coli with R-loops of various structures were investigated. It was found that the values of the dissociation constants K
d were minimal for complexes of RH1 with model R-loops containing a 10–11-nt RNA–DNA hybrid part, indicating effective binding. Analysis of the kinetics of RNA degradation in the R-loops by RH1 revealed that the rate-limiting step of the process was catalytic-complex formation. In the presence of RNA polymerase, the R-loops containing a ≤16-nt RNA–DNA hybrid part were efficiently protected from cleavage by RH1. In contrast, R-loops containing longer RNA–DNA hybrid parts, as a model of an abnormal transcription process, were not protected by RNA polymerase and were effectively digested by RH1. [ABSTRACT FROM AUTHOR]- Published
- 2024
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21. Role of R-Loop Structure in Efficacy of RNA Elongation Synthesis by RNA Polymerase from Escherichia coli.
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Timofeyeva, Nadezhda A., Tsoi, Ekaterina I., Novopashina, Darya S., Kuznetsova, Aleksandra A., and Kuznetsov, Nikita A.
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RNA synthesis ,NUCLEIC acids ,GENETIC transcription ,SINGLE-stranded DNA ,ENZYME kinetics ,RNA polymerases - Abstract
The mechanism of transcription proceeds through the formation of R-loop structures containing a DNA–RNA heteroduplex and a single-stranded DNA segment that should be placed inside the elongation complex; therefore, these nucleic acid segments are limited in length. The attachment of each nucleotide to the 3′ end of an RNA strand requires a repeating cycle of incoming nucleoside triphosphate binding, catalysis, and enzyme translocation. Within these steps of transcription elongation, RNA polymerase sequentially goes through several states and is post-translocated, catalytic, and pre-translocated. Moreover, the backward movement of the polymerase, which is essential for transcription pausing and proofreading activity, gives rise to a backtracked state. In the present study, to analyze both the efficacy of transcription elongation complex (TEC) formation and the rate of RNA synthesis, we used a set of model R-loops that mimic the pre-translocated state, post-translocated state, backtracked state, and a misincorporation event. It was shown that TEC assembly proceeds as an equilibrium process, including the simultaneous formation of a catalytically competent TEC as well as a catalytically inactive conformation. Our data suggest that the inactive complex of RNA polymerase with an R-loop undergoes slow conformational changes, resulting in a catalytically competent TEC. It was revealed that the structural features of R-loops affect the ratio between active and inactive states of the TEC, the rate of conformational rearrangements required for the induced-fit transition from the inactive state to the catalytically competent TEC, and the rates of accumulation of both the total RNA products and long RNA products. [ABSTRACT FROM AUTHOR]
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- 2024
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22. Template-Induced Crystallization of Novel Orthorhombic 9,10-Diphenylanthracene Polymorph.
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Sonina, Alina A., Cheshkina, Darya S., and Kazantsev, Maxim S.
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- 2024
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23. Numerical Simulation of Generation, Distribution, and Impact of a High-Specific Energy Plasma Bunch on a Barrier
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Stupitsky, Evgeniy L., Motorin, Andrey A., Moiseeva, Darya S., Howlett, Robert J., Series Editor, Jain, Lakhmi C., Series Editor, Favorskaya, Margarita N., editor, Nikitin, Ilia S., editor, and Reviznikov, Dmitry L., editor
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- 2021
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24. Foreign Practice of Application of Smart Technologies to Support Technological Entrepreneurship: Prospects for Application in Russia
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Korobov, Sergei A., Moseyko, Viktor O., Marusinina, Elena Y., Devyatkina, Darya S., Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Popkova, Elena G., editor, and Sergi, Bruno S., editor
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- 2021
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25. The Role of Artificial Intelligence in Professional Legal Sphere: Development Tool or Existential Threat?
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Miroshnichenko, Olga I., Proscurina, Darya S., Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Popkova, Elena G., editor, and Sergi, Bruno S., editor
- Published
- 2021
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26. Treatment of postoperative tibial chronic osteomyelitis using bone transport techniques; an observational study
- Author
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Kliushin, Nikolay Mikhailovich, Burnashov, Sergy I., Mekki, Waleed Ahmed, Leonchuk, Darya S., and Sudnitsyn, Anatoliy Sergeyevich
- Published
- 2022
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27. The effectiveness of a territory’s spatial development as an indicator of regional authorities performance: The case of Chelyabinsk oblast
- Author
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Darya S. Bents
- Subjects
regional management effectiveness ,regional authorities ,spatial development ,socio-economic development ,chelyabinsk oblast ,sverdlovsk oblast ,center – periphery ,Business ,HF5001-6182 ,Finance ,HG1-9999 - Abstract
The need for effective development and use of space is a key task posed in the strategic planning documents of the Russian Federation. The “periphery–center” migration of resources and a declining ability of regions to reproduce high-quality human potential question the possibility of achieving the goals of effective spatial development. The added complication is that regions are extremely rigid when it comes to decision-making, since the policy of the “center” dictates every move of regional authorities. The article systematizes research and regulatory materials in the field of spatial development. It aims to formulate a methodology for assessing the performance of regional authorities, which should meet the following requirements: (i) be transparent and do not include indicators that governors are practically unable to change, and (ii) be integrated and focused on not only the socio-economic, but also spatial development of the region. The methodological basis of the research includes the theories of spatial development, including cumulative growth theories. The methods of statistical comparison, dynamics analysis and correlation analysis are applied. The information base covers legal acts; strategic planning documents; Rosstat statistical data; socio-economic rankings of regions, and management effectiveness rankings of the RF constituent entities. The study reveals the development trends in Chelyabinsk oblast’s economic space. It positions the region in the “center – periphery” system and shows its underperformance in comparison with Sverdlovsk oblast in the sphere of economic development (the level of GRP per capita is lagging behind the indicators of Sverdlovsk oblast and the national average), financial well-being (despite a high margin of financial strength, the income of Chelyabinsk region’s population is 1.5 times lower than in Sverdlovsk oblast), human capital (both in statics as of the end of 2019 and in dynamics since 2010, Chelyabinsk oblast demonstrates more negative results in relation to the number of students, postgraduate students, doctoral students, researchers with scientific degrees, etc.). The author raises the question about the gradual inclusion of spatial development indicators in the list of the existing indicators for assessing regional authorities performance.
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- 2022
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28. Technological Infrastructure of the 'Green' Digital Economy: Measurement and Management Methodology
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Dzakhmisheva, Irina Sh., Titova, Olga V., Robets, Darya S., Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Popkova, Elena G., editor, and Sergi, Bruno S., editor
- Published
- 2020
- Full Text
- View/download PDF
29. Scalp hair sweating as a predictor of hair cortisol level in human compared to obesity and other confounders
- Author
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Darya S. Abdulateef
- Subjects
Medicine ,Science - Abstract
Abstract Inconsistent results were found throughout the literature regarding factors affecting hair cortisol levels. Hair cortisol level in humans was not studied for its associations to scalp hair sweating or hair wash frequency in a patient-based way. Factors affecting hair cortisol levels must be precisely known in order to interpret the results correctly. The aims of the study are to assess if BMI, Perceived Stress Scale (PSS), hair wash frequency, and sweating with scalp hair affect hair cortisol levels. It will assess which of these factors are more significant predictors of hair cortisol levels. In a study on healthy adults, information about history, socio-demographics, PSS, hair wash frequency, hair treatment, and scalp hair sweating were collected, and hair samples were taken and analyzed for their hair cortisol level. Associations of hair cortisol levels with each of the variables were investigated and significant predictors of hair cortisol levels among the variables were found. Mean hair cortisol level in the study participants was 16.84 pg/mg hair. Hair cortisol has a significant positive association with weight, BMI, PSS, and scalp hair sweating, p
- Published
- 2021
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30. Criteria for the optimal use of interleukin-6 receptor blockers in patients with COVID-19
- Author
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Tatyana S. Kruglova, Darya S. Fomina, Nataliya G. Poteshkina, Nadija F. Frolova, Irina P. Beloglazova, Zinaida Yu. Mutovina, Inna V. Samsonova, Elena A. Kovalevskaja, Alena I. Zagrebneva, Sofya A. Serdotetckova, Anton A. Chernov, and Maryana A. Lysenko
- Subjects
covid-19 ,interleukin-6 ,interleukin-6 receptor blockers ,tocilizumab ,sarilumab ,Medicine - Abstract
Aim. To determine the criteria for the optimal use of IL-6 receptor blockers in patients with COVID-19 community-acquired pneumonia based on predictors of adverse outcomes. Materials and methods. The single-center, non-randomized prospective study included 190 patients with community-acquired pneumonia caused by coronavirus 2 between the beginning of March and the end of May 2020. Of these, 89 patients received tocilizumab and 101 patients received sarilumab. The study inclusion criterion for the patient was indications for initiating therapy with one of the inhibitors of IL-6 receptors (anti-IL-6R) according to the Interim guidelines (versions 4 and 5). The exclusion criterion was the need to re-prescribe genetically engineered biological therapy (GEBT). The severity of the patient's condition was assessed according to the early warning score (NEWS2), the volume of lung tissue lesions was assessed according to computed tomography (CT). Laboratory monitoring included counting the absolute (abs) number of lymphocytes, serum levels of C-reactive protein (CRP), interleukin 6 (IL-6), D-dimer, lactate dehydrogenase, fibrinogen. Statistical data processing was conducted by nonparametric methods using the IBM SPSS Statistics V-22 software. Results. The phenotype of a patient with a negative outcome prognosis was described: a male patient over 50 years of age with aggravated premorbid background (with cardiovascular diseases, obesity and/or chronic renal disease), lung lesion CT 34, saturation less than 93% upon inhalation of atmospheric air, persisting for 2448 hours after GEBT. According to the blood test, lymphopenia was below 1000 U/L and CRP levels were above 50 mg/L. The laboratory parameters and clinical picture of the patient progressively worsened after 911 days of illness, regardless of the use of Anti-IL-6R. The features of patients monitoring when administering IL-6 receptor blockers have been determined. Conclusion. IL-6 receptor blockers should be administered to patients hospitalized with severe COVID-19 before the development of hyperinflammatory reactions. The optimal "therapeutic window" is 78 days of illness.
- Published
- 2021
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31. SUBSTITUTED 4-NITROSOPYRAZOLES IN THE DIELS-ALDER REACTION
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Darya S. Volkova, Arkadiy A. Popov, Evgeny V. Root, Alexey A. Kukushkin, and George A. Suboch
- Subjects
nitrosopyrazoles ,tetracyclone ,diels-alder reaction ,diene condensation ,pass-online ,hplc/ms ,mass-spectrometry ,Agriculture ,Science - Abstract
Background. 4-Nitrosopyrazoles have become widespread in the pharmaceutical industry and in chemistry due to their high reactivity and biological activity. However, the interaction of 3,5-substituted 4-nitroso-1H-pyrazoles with diene hydrocarbons has not been studied to date. Purpose. Study of diene condensation of tetraphenylcyclopentadienone with 3,5-dimethyl-4-nitroso-1H-pyrazole and 3(5)-methyl-4-nitroso-5(3)-phenyl-1H-pyrazole; proof of the structure of the obtained compounds; prediction of potential positive biological activity. Materials and methods. Research methods include: directed organic synthesis, thin-layer chromatography, chromato-mass spectra, prediction of biological activity using the PASS-online web-resource. Results. Substituted oxazines, pyrazoles and but-2-en-1-ones were synthesized. Fragmentation decays based on the mass spectrum of the obtained compounds confirm their molecular weight and structure. The PASS-online program predicts potential biological activity. Conclusion. Substituted oxazines, pyrazoles and but-2-en-1-ones were obtained for the first time by the Diels-Alder reaction, the structure of which was proved by HPLC/MS. Based on the output data of the PASS-online program, the synthesized substances are taurine dehydrogenase inhibitors and exhibit antitumor effect.
- Published
- 2021
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32. The efficacy and safety of levilimab in severely ill COVID-19 patients not requiring mechanical ventilation: results of a multicenter randomized double-blind placebo-controlled phase III CORONA clinical study
- Author
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Lomakin, Nikita V., Bakirov, Bulat A., Protsenko, Denis N., Mazurov, Vadim I., Musaev, Gaziyavdibir H., Moiseeva, Olga M., Pasechnik, Elena S., Popov, Vladimir V., Smolyarchuk, Elena A., Gordeev, Ivan G., Gilyarov, Mikhail Yu, Fomina, Darya S., Seleznev, Anton I., Linkova, Yulia N., Dokukina, Ekaterina A., Eremeeva, Anna V., Pukhtinskaia, Polina S., Morozova, Maria A., Zinkina-Orikhan, Arina V., and Lutckii, Anton A.
- Published
- 2021
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33. Effect of time-dependent wall temperature on natural convection of a non-Newtonian fluid in an enclosure
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Loenko, Darya S., Shenoy, Aroon, and Sheremet, Mikhail A.
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- 2021
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34. Fractional-order-Bessel Fourier-invariant optical vortices
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Kotlyar, Victor V., Kovalev, Alexey A., and Kalinkina, Darya S.
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- 2021
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35. Single Ionization of Helium by Protons of Various Energies in the Parabolic Quasi-Sturmians Approach
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Alexander S. Zaytsev, Darya S. Zaytseva, Sergey A. Zaytsev, Lorenzo U. Ancarani, Ochbadrakh Chuluunbaatar, Konstantin A. Kouzakov, and Yury V. Popov
- Subjects
ionization by proton impact ,parabolic quasi-Sturmians ,Lippmann–Schwinger equation ,convergence of the differential cross-section ,Nuclear and particle physics. Atomic energy. Radioactivity ,QC770-798 - Abstract
The parabolic quasi-Sturmian approach, recently introduced for the calculation of ion–atom ionizing collisions, is adapted and applied here to the single ionization of helium induced by an intermediate-energy proton impact. Within the method, the ionization amplitude is represented as the sum of the products of the basis amplitudes associated with the asymptotic behavior of the continuum states of the two noninteracting hydrogenic subsystems (e−,He+) and (p+,He+). The p−e interaction is treated as a perturbation in the Lippmann–Schwinger-type (LS) equation for the three-body system (e−,He+,p+). This LS equation is solved numerically using separable expansions for the proton–electron potential. We examine the convergence behavior of the transition amplitude expansion as the number of terms in the representation of the p−e interaction is increased and find that, for some kinematic regimes, the convergence is poor. This difficulty, which is absent for a higher proton energy impact, is solved by varying the momentum of the auxiliary proton plane wave introduced into the basis function. Fully differential cross-sections are calculated and compared with experimental data for 75 keV protons and the results obtained with the 3C model.
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- 2023
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36. Spectral and Cathodoluminescence Decay Characteristics of the Ba1−xCexF2+x (x = 0.3–0.4) Solid Solution Synthesized by Precipitation from Aqueous Solutions and Fusion
- Author
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Sergey V. Kuznetsov, Darya S. Yasyrkina, Damir T. Valiev, Sergey A. Stepanov, Alexander A. Alexandrov, Sergey Kh. Batygov, Valeriy V. Voronov, Vasilii A. Konyushkin, Andrey N. Nakladov, Julia A. Ermakova, and Pavel P. Fedorov
- Subjects
barium fluoride ,cerium fluoride ,solid solution ,cathodoluminescence ,Applied optics. Photonics ,TA1501-1820 - Abstract
Single-phase samples of the Ba1−xCexF2+x solid solution (x = 0.3–0.4) were synthesized by directional crystallization in the form of single crystals and by co-precipitation from aqueous nitrate solutions using potassium fluoride as a fluorinating agent in the form of nanopowders. The cathodoluminescence of the pressed powder samples was studied in comparison with the BaF2: Ce single crystals in 250–460 nm (2.7–5 eV) spectral range upon excitation by an electron accelerator. The cathodoluminescence spectra of the samples revealed a wide band in the range of 3.0–4.0 eV, which consists of two typical components of Ce3+ with decay time 23 ns in the case of single crystals and three decay times 27 ns, 140–170 ns, and ~600 ns in the case of pressed powders. The decay time of the short-wavelength component (27 ns) in the case of pressed powders is close to the lifetime of the excited state of the Ce3+ ion. The developed X-ray phosphors can be applied for embedding in diamonds for diamond–nanoparticle composite preparation.
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- 2023
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- View/download PDF
37. Mathematical Modeling of Dynamic and Optical Effects in Ionospheric Experiments Using an Explosive Chemical Generator
- Author
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Stupitsky, Evgeniy L., primary, Motorin, Andrey A., additional, and Moiseeva, Darya S., additional
- Published
- 2022
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38. Synthesis of 5-arylacetylenyl-1,2,4-oxadiazoles and their transformations under superelectrophilic activation conditions
- Author
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Andrey I. Puzanov, Dmitry S. Ryabukhin, Anna S. Zalivatskaya, Dmitriy N. Zakusilo, Darya S. Mikson, Irina A. Boyarskaya, and Aleksander V. Vasilyev
- Subjects
acetylene-oxadiazoles ,friedel–crafts reaction ,hydroarylation ,superelectrophilic activation ,triflic acid ,Science ,Organic chemistry ,QD241-441 - Abstract
Acetylene derivatives of 1,2,4-oxadiazoles, i.e., 5-(2-arylethynyl)-3-aryl-1,2,4-oxadiazoles, have been obtained, for the first time reported, from 5-(2-arylethenyl)-3-aryl-1,2,4-oxadiazoles by their bromination at the carbon–carbon double bond followed by di-dehydrobromination with NaNH2 in liquid NH3. The reaction of the acetylenyl-1,2,4-oxadiazoles with arenes in neat triflic acid TfOH (CF3SO3H) at room temperature for 1 h resulted in the formation of E/Z-5-(2,2-diarylethenyl)-3-aryl-1,2,4-oxadiazoles as products of regioselective hydroarylation of the acetylene bond. The addition of TfOH to the acetylene bond of these oxadiazoles quantitatively resulted in E/Z-vinyl triflates. The reactions of the cationic intermediates have been studied by DFT calculations and the reaction mechanisms are discussed.
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- 2021
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39. Inhibition of Class A β‑Lactamase (TEM-1) by Narrow Fractions of Humic Substances
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Tatyana A. Mikhnevich, Alexandra V. Vyatkina (Turkova), Vitaly G. Grigorenko, Maya Yu. Rubtsova, Gleb D. Rukhovich, Maria A. Letarova, Darya S. Kravtsova, Sergey A. Vladimirov, Alexey A. Orlov, Evgeny N. Nikolaev, Alexander Zherebker, and Irina V. Perminova
- Subjects
Chemistry ,QD1-999 - Published
- 2021
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40. Dynamically Changing Parallelism with Asynchronous Sequential Data Flows.
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Alexander Ivanovich Legalov, Ivan V. Matkovskii, Mariya S. Ushakova, and Darya S. Romanova
- Published
- 2021
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41. Integrative verbal knowledge as the basis for the formation of students’ communicative competence
- Author
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Lyubov D. Ponomareva, Olga V. Gnevek, Oksana V. Dorfman, Darya S. Buzhinskaya, Maria L. Skvortsova, and Ekaterina A. Gubchevskaya
- Subjects
Integrative verbal knowledge ,Language ability ,Students’ communicative competence ,Creative language use ,Speech-creative development ,Education (General) ,L7-991 ,Special aspects of education ,LC8-6691 - Abstract
This article presents a process of forming students’ communicative competence through integrative verbal knowledge, the purpose of which is to prepare an individual who is able to perceive, reproduce and create texts of different styles and genres. The leading research methods of the problem are the design of students’ language activities and experimentation with the word and text. It has been concluded that the design of students’ activities facilitates a solution of a set of didactic problems. By means of an example of the organization of educational and research work concerning integrative verbal knowledge in high school, the possibilities of using research work in the process of speech-creative development of students have been considered and a general conclusion about the effectiveness of the formation of communicative competence of students on the basis of integrative verbal knowledge has been made.
- Published
- 2022
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42. Ecological vs physiological host specificity: the case of the microsporidium Nosema pyrausta (Paillot) Weiser, 1961
- Author
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Yuri S. Tokarev, Darya S. Kireeva, Anastasia N. Ignatieva, Aleksander A. Ageev, Aleksei V. Gerus, Olga N. Yaroslavtseva, Anastasia G. Kononchuk, and Julia M. Malysh
- Subjects
microsporidia ,microbial control ,bioassay ,virulence ,lepidopteran pest ,Biology (General) ,QH301-705.5 - Abstract
The microsporidium Nosema pyrausta (Paillot) Weiser, 1961 plays an important role in the mortality of the European corn borer Ostrinia nubilalis (Hübner, 1796), and shows high virulence to the beet webworm Loxostege sticticalis (Linnaeus, 1761). In contrast, the greater wax moth Galleria mellonella (Linnaeus, 1758) and the gypsy moth Lymantria dispar (Linnaeus, 1758) are referred to as resistant hosts, slightly susceptible to this microparasite. The goal of the present study was to test N. pyrausta against a broad range of lepidopteran species with different taxonomy, physiology, and ecology. The susceptibility to N. pyrausta spores fluctuated greatly among members of various families and superfamilies of Lepidoptera. As many as 13 species tested were found to be refractory (not able to support the development of the microsporidium), including three species of Yponomeutoidea, four species of Papilionoidea, one species of Pyraloidea, two species of Bombycoidea, and three species of Noctuoidea. The species found to be susceptible (with a high proportion of specimens displaying developed infection) included: Evergestis forficalis (Linnaeus, 1758) (Crambidae), Aglais urticae (Linnaeus, 1758) (Nymphalidae), and Dendrolimus sibiricus Chetverikov, 1908 (Lasiocampidae). The species newly found to be highly susceptible (high proportion of infected insects accompanied with high levels of early mortality) were: Spodoptera exigua (Hübner, 1808) (Noctuidae) and Aglais io (Linnaeus, 1758). Large quantities of spores can be produced in vivo using substitute laboratory host A. urticae. These results confirm previous observations that physiological host range of microsporidia (observed under experimental conditions) is broader than the ecological one (observed in nature).
- Published
- 2022
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43. The serum vascular endothelial growth factor levels in patients with high-energy trauma complicated with infection
- Author
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Anastasia A. Rakhmatulina, Svetlana N. Luneva, Natalia V. Nakoskina, Nikolai M. Kliushin, Sergei V. Lyulin, Tamara I. Dolganova, Tatyana I. Menshchikova, and Darya S. Leonchuk
- Subjects
high-energy trauma ,growth factors ,connective tissue ,osteomyelitis ,Orthopedic surgery ,RD701-811 - Abstract
Introduction There is a lack of studies analyzing the molecular aspects of body functioning in purulent complications of bone tissue. The purpose of the review was to explore the serum vascular endothelial growth factor (VEGF) levels in patients with high-energy trauma complicated with infection. Material and methods The study included 36 individuals who sustained a high-energy injury. The participants were identified as no-infection patients (Group I) and those who developed infection during treatment (Group II). Enzyme immunoassay was employed to quantify VEGF with Thermofisher immunoassay analyzer (USA). The study was performed according to the methodology from the R & D Systems kit manual (Angiopoietin-1 and -2 (Ang-1, Ang-2)), platelet-derived growth factors (PDGF-AB, PDGF-BB), Invitrogen (epidermal growth factor (EGF), vascular endothelial growth factor (VEGF), RayBiotech (macrophage stimulating protein (MSP), Biomerika Inc. (Calcitonin-calciotonin) USA) and Immunodiagnostic (bone sialoprotein (BSP) (Germany). HITACHI HI Vision Avius ultrasound scanner was used to explore vessels of the soft tissues and the periosteum at the site of regeneration (defect). Results There were no differences in the serum growth factor levels among the participants by gender. Patients of Group II showed 60% reduction in the Ang-2 and VEGF concentration as compared with that in the no-infection group. The serum EGF concentration was 1.6 times higher in individuals suffering from complications of high-energy trauma than in no-infection patients. There were no significant differences in platelet-derived growth factor PDGF-AB, PDGF-BB between the groups. Сhanges in the VEGF concentration were confirmed by the results of Doppler ultrasonography. Conclusion The findings suggest that the VEGFs examined can be additional diagnostic and prognostic markers for the cohort of patients.
- Published
- 2021
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44. Additive-Assisted Crystallization of 9,10-Diphenylanthracene
- Author
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Alina A. Sonina, Darya S. Cheshkina, and Maxim S. Kazantsev
- Subjects
additive-assisted crystallization ,polymorphism ,conjugated small molecules ,organic semiconductors ,organic electronics ,Crystallography ,QD901-999 - Abstract
Crystallization control of organic conjugated small molecules is in high demand for the engineering of functional materials in organic optoelectronics. Here, we report solution additive-assisted crystallization of a model non-planar aromatic hydrocarbon derivative 9,10-diphenylanthracene. Among the studied series of related aromatic hydrocarbons comprising pyrene, perylene, anthracene, tetracene, and rubrene, only tetracene revealed clear reproducible effects allowing one to perform selective crystallization of metastable 9,10-diphenylanthracene polymorphs. Additionally, crystallization of 9,10-diphenylanthracene and pyrene produced a stoichiometric co-crystal (PYR–DPA) having a segregated layered molecular packing with alternating 9,10-diphenylanthracene and pyrene layers. Remarkably, the molecular packing of pyrene within the co-crystal is unique and represented by the herringbone motif, whereas the molecular packing in known pyrene polymorphs is represented by π-stacked molecules. The co-crystal also demonstrated a bright photoluminescence with a photoluminescence quantum yield of 51%. Considering the morphology of 9,10-diphenylanthracene crystals obtained and crystal structures of PYR–DPA co-crystal and tetracene, we have proposed the mechanism of additive-assisted polymorphism based on the inhibition of (111) facet of α-DPA and promoting of the layered structure crystallization corresponding to metastable polymorphs (β- and γ-DPA). We highlight the additive-assisted crystallization approach as a powerful tool for the crystal engineering of functional materials for organic optoelectronics.
- Published
- 2023
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- View/download PDF
45. Yedoma Permafrost Releases Organic Matter with Lesser Affinity for Cu2+ and Ni2+ as Compared to Peat from the Non-Permafrost Area: Risk of Rising Toxicity of Potentially Toxic Elements in the Arctic Ocean
- Author
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Nikita A. Sobolev, Konstantin S. Larionov, Darya S. Mryasova, Anna N. Khreptugova, Alexander B. Volikov, Andrey I. Konstantinov, Dmitry S. Volkov, and Irina V. Perminova
- Subjects
humic substances ,Yedoma ice complex ,alas ,Arctic ,potentially toxic elements ,Langmuir model ,Chemical technology ,TP1-1185 - Abstract
Pollution of the Arctic Ocean by potentially toxic elements (PTEs) is a current environmental problem. Humic acids (HAs) play an important role in the regulation of PTE mobility in soil and water. The permafrost thaw releases ancient organic matter (OM) with a specific molecular composition into the Arctic watersheds. This could affect the mobility of PTEs in the region. In our study, we isolated HAs from two types of permafrost deposits: the Yedoma ice complex, which contains pristine buried OM, and the alas formed in the course of multiple thaw–refreezing cycles with the most altered OM. We also used peat from the non-permafrost region as the recent environmental endmember for the evolution of Arctic OM. The HAs were characterized using 13C NMR and elemental analysis. Adsorption experiments were conducted to assess the affinity of HAs for binding Cu2+ and Ni2+. It was found that Yedoma HAs were enriched with aliphatic and N-containing structures as compared to the much more aromatic and oxidized alas and peat HAs. The adsorption experiments have revealed that the peat and alas HAs have a higher affinity for binding both ions as compared to the Yedoma HAs. The obtained data suggest that a substantial release of the OM from the Yedoma deposits due to a rapid thaw of the permafrost might increase the mobility of PTEs and their toxicity in the Arctic Ocean because of much lesser “neutralization potential”.
- Published
- 2023
- Full Text
- View/download PDF
46. Comorbidity of diseases of the cardiovascular system and diseases of the digestive organs with changes in organs and tissue of the oral cavity
- Author
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Dmitry I. Trukhan, Larisa Yu. Trukhan, and Darya S. Ivanova
- Subjects
dentistry ,cardiology ,gastroenterology ,comorbidity ,polymorbidity ,drug therapy ,Internal medicine ,RC31-1245 - Abstract
Currently, in most clinical cases, the patient has a concomitant or combined pathology described by the terms "polymorbidity" (in the absence of a pathogenetic relationship) and "comorbidity" (in the presence of a pathogenetic relationship) between various diseases and pathological conditions. In the system of relationships between an internist and physicians of other specialties, the least studied aspects of their clinical interaction with a dentist. At the same time, often the reason for a patient's visit to the dentist is the presence of somatic pathology, and for the most part, not completely healthy patients come to the dentist's appointment, whose problems are limited to the oral cavity. On the other hand, the presence of certain changes in organs and tissues of the oral cavity and the advice of a dentist can help the internist in the diagnosis and adequate treatment of the patient. The first part of the presented review examines possible changes in the organs and tissues of the oral cavity in patients with diseases of the cardiovascular system and diseases of the digestive system. The second part of the review is devoted to the analysis of the possible effect on the organs and tissues of the oral cavity of drugs used to treat cardiovascular and gastroenterological diseases.
- Published
- 2021
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- View/download PDF
47. Peculiarities of electrophoretic deposition and morphology of deposited films in non-aqueous suspensions of Al2O3–Al nanopowder
- Author
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Elena G. Kalinina, Darya S. Rusakova, and Elena Yu. Pikalova
- Subjects
electrophoretic deposition ,electric explosion of wire ,alumina weakly aggregated nanopowder ,non-aqueous suspension ,zeta potential ,Chemistry ,QD1-999 - Abstract
The paper presents the results of a comprehensive study of the electrokinetic properties of non-aqueous suspensions of the Al2O3–Al nanopowder obtained by the method of electric explosion of wires (EEW) with 0.3 wt.% of metallic aluminum in its composition. The dependence of zeta potential on the concentration of the Al2O3–Al suspension is revealed. The nature of long-term changes in zeta potential and pH in suspensions is established. Appearance of bubbles in the deposited coatings due to the interaction of metallic aluminum particles with the liquid suspension medium during electrochemical reactions on the electrodes is defined as the main feature of the electrophoretic deposition (EPD) process in the Al2O3–Al suspensions. The influence of the suspension preparation method on the deposited coatings’ morphology is demonstrated.
- Published
- 2022
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- View/download PDF
48. Photoinduced Electron Transfer between Dipolar Reactants: Solvent and Excitation Wavelength Effects
- Author
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Verma, Pragya, primary, Budkina, Darya S., additional, and Vauthey, Eric, additional
- Published
- 2024
- Full Text
- View/download PDF
49. Monitoring of gram-negative bacteria and antibiotic resistance in osteomyelitis
- Author
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Irina V. Shipitsyna, Elena V. Osipova, Darya S. Leonchuk, and Anatoly S. Sudnitsyn
- Subjects
osteomyelitis ,gram-negative bacteria ,antibiotic resistance ,beta-lactam antibiotics ,multi-drug resistance ,Orthopedic surgery ,RD701-811 - Abstract
Introduction There is an urgent need for a surveillance system of regular monitoring of specific bacteria inducing various types of osteomyelitis to identify resistant isolates and optimize the use of antibiotics. Objective: monitoring of specific gram-negative bacteria and analysis of the antibiotic resistance of the strains isolated from osteomyelitis patients over a three-year period. Results and discussion P. aeruginosa was the first most common pathogen among gram-negative microorganisms isolated from the patients between 2017 and 2019. Prevalence of the isolates identified in 2019 decreased by 9.6 % as compared to 2017. Next frequently encountered clinical isolates were Enterobacter sp., Acinetobacter sp., Klebsiella sp. There was a twofold increase in K. pneumoniae strains isolated in 2019. Analysis of antibiotic susceptibility testing data revealed multiresistance of the Acinetobacter sp. strains in 2019 despite the total decrease in resistant isolates in 2017 and 2018. Among non-fermenting gram-negative rods, the species being resistant to imipenem were shown to increase by 5.4 times. Overall antibiotic resistance was on rise. Increased antimicrobial resistance to beta-lactam antibiotics also combined with BLaC inhibitors was observed in Enterobacteriaceae population. Meropenem was found to be effective against most bacteria with growing drug resistance observed as compared with recent years. The antibiotic resistance profiles of Klebsiella sp. strains appeared to be high at antimicrobial testing. Conclusion Diverse bacterial morphology of gram-negative species and increasing proportion of drug-resistant strains isolated in osteomyelitis cases have necessitated regular monitoring of multiresistant clinical isolates for adjustment of empirical antibiotic therapies.
- Published
- 2020
- Full Text
- View/download PDF
50. Phenological phenomena in the life of plants in Zhiguli Nature Reserve in the changing climate (using the example of Laser trilobum and Euphorbia zhiguliensis)
- Author
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Darya S. Kiseleva
- Subjects
phenology ,rare species ,zhiguli nature reserve ,climate change ,laser trilobum ,euphorbia zhiguliensis ,mean air temperature ,amount of precipitation ,Environmental sciences ,GE1-350 - Abstract
Phenological processes of two rare species, Laser trilobum and Euphorbia zhiguliensis, in Zhiguli Reserve, and their changes associated with climate change during more than 38 years of observations are discussed. Long-term weather condition phenorhythms in the reserve were summarized, and the behavior of the plants in the changing environment was studied..
- Published
- 2020
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