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Esse artigo objetiva fazer uma abordagem sobre o descarte de medicamentos e a logística reversa. A partir desse ponto, identificou-se a importância de compreender como a população entende o que é logística reversa e como é feito o descarte adequado de medicamentos. Com embasamento teórico e pesquisa quali-quantitativa passa-se a ter maior conhecimento sobre todos os processos que envolvem a logística reversa e a conscientização da população sobre o assunto abordado. Com o questionário elaborado em uma ferramenta do Google voltada a pesquisa conseguiu-se através da pesquisa quali-quantitativa fazer análises da percepção da população em relação ao conhecimento da logística reversa no descarte de medicamentos que entendem sobre o descarte inadequado e os prejuízos causados ao meio ambiente.

Melanocytes are essential for skin homeostasis and protection, and their loss or misfunction leads to a wide spectrum of diseases. Cell therapy utilizing autologous melanocytes has been used for years as an adjunct treatment for hypopigmentary disorders such as vitiligo. However, these approaches are hindered by the poor proliferative capacity of melanocytes obtained from skin biopsies. Recent advances in the field of human pluripotent stem cells have fueled the prospect of generating melanocytes. Here, we have developed a well-characterized method to produce a pure and homogenous population of functional and proliferative melanocytes. The genetic stability and potential transformation of melanocytes from pluripotent stem cells have been evaluated over time during the in vitro culture process. Thanks to transcriptomic analysis, the molecular signatures all along the differentiation protocol have been characterized, providing a solid basis for standardizing the protocol. Altogether, our results promise meaningful, broadly applicable, and longer-lasting advances for pigmentation disorders and open perspectives for innovative biotherapies for pigment disorders.

Denna studie handlar om förskolepersonalens uppfattningar av orosanmälningar. Syftet med studien är att synliggöra hur förskolepersonalen ser på sitt ansvar kring anmälningsplikten och vilka faktorer som påverkar dem vid orosanmälningar. Enligt Socialtjänstlagen (SFS 2001:453) ska alla som är verksamma inom förskolan anmäla till socialnämnden vid misstanke eller kännedom om att barn far illa. Ayling m.fl. (2020) lyfter att det finns flera faktorer som påverkar personalen när en anmälan ska göras. Även Markström och Münger (2020) lyfter att det finns rädslor hos personalen som påverkar dem när de står inför att göra en orosanmälan.Undersökningen utgår från en metodtriangulering, som innebär en kombination av en kvalitativ och kvantitativ undersökning. För insamling av data har en enkätundersökning, med öppna och slutna frågor gjorts. Den teori som ligger till grund för studien är fenomenografisk metodansats, där fokuset ligger på fenomenet om uppfattningar av ansvaret. Analysen är gjord med hjälp av fenomenografisk analys samt en univariat analys. Resultaten som synliggjorts var dels att personalen såg sitt ansvar kring anmälningsplikten som en viktig del i sin yrkesroll. Men att de upplever det som en svår uppgift, bland annat vid identifieringen av barn som far illa. Dessutom finns det en rädsla för vårdnadshavarnas reaktioner, samt att anmäla oskyldiga och utsätta familjen för onödigt trauma. Den faktor som påverkar personalen mest när en anmälan upprättas är kollegornas och ledningens stöd, utan stöd förekommer det att anmälan uteblir. This study is about preschool staff's conceptions of mandatory reporting of children in need. The purpose of this study is to make visible how preschool staff view their responsibility regarding mandatory reporting when there is suspicion or knowledge that children are being harmed in any way. According to the Social Services Act (SFS 2001:453), everyone who is working in preschool must report to the social welfare board if there is suspicion or knowledge that children are being harmed. Ayling et al. (2020) highlight that there are several factors that affect the staff before a report is filed. Markström and Münger (2020) also highlight that there are fears among the staff that affect them when faced with making a report of concern.This study is based on a methodological triangulation, which involves a combination of a qualitative and quantitative examination. For the collection of data, a survey, with open-ended and closed-ended questions, has been conducted. The theory that forms the basis of the study is that of the phenomenographic method approach, where the focus has been on the phenomenon of conceptions of responsibility. The analysis is made using phenomenographic analysis as well as a univariate analysis. The conclusion of the study is that the staff see their responsibility regarding the obligation to report as a daunting part of their professional roles. They experience it as a difficult task, for example the identification of children in need is perceived as problematic. There is also a fear of negative reactions from the guardians. Another challenge is the fear of reporting innocents and thereby exposing the family to unnecessary trauma. Shared responsibility of the report from both colleagues and management is the factor that most often leads to the reporting of concerns. In cases where there is a lack of shared support, reports are not filed.

Epidermolysis bullosa simplex (EBS), an autosomal dominant skin disorder, is characterized by skin fragility. Genetically, the majority of cases are related to missense sequence variations in two keratin genes K5 or K14, leading to cytolysis of basal keratinocytes (KCs) and intraepidermal blistering. Progress toward the identification of treatments has been hampered by an incomplete understanding of the mechanisms underlying this disease and availability of relevant and reliable in vitro models recapitulating the physiopathological mechanisms. Recent advances in stem cell field have fueled the prospect that these limitations could be overcome, thanks to the availability of disease-specific human induced pluripotent stem cells (hiPSCs). In this study, we generated hiPSC-derived KCs from patients carrying keratin gene K5-dominant sequence variations and compared them with nonaffected hiPSC-derived KCs as well as their primary counterparts. Our results showed that EBS hiPSC-derived KCs displayed proliferative defects, increased capacity to migrate, alteration of extracellular signal‒regulated kinase signaling pathway, and cytoplasmic keratin filament aggregates as observed in primary EBS KCs. Of interest, EBS hiPSC-derived KCs exhibited downregulation of hemidesmosomal proteins, revealing the different effects of keratin gene K5 sequence variations on keratin cytoskeletal organization. With a combination of culture miniaturization and treatment with the chaperone molecule 4-phenylbutyric acid, our results showed that hiPSC-derived KCs represent a suitable model for identifying novel therapies for EBS.

I fäljande kvalitativa studie undersöks utbyggnaden av vindkraftparken Markbygdens påverkan på den svenska skogssamebyn Östra Kikkejaure sameby. Projektet väntas bestå av 1101 vindkraftverk och drivs av ansvarig entreprenör, Svevind AB. Projektet byggs i Piteå kommun och berör bland annat Östra Kikkejaures renbetesmarker. Syftet med studien är att undersöka vad utbyggnaden av vindkraftparker kan ha för påverkan på en svensk sameby. Vidare är syftet också att undersöka vilka konsekvenser som kan uppstå för samebyn, vilka intressekonflikter som kan identifieras och hur inställningen till vindkraftsprojekt kan påverkas. Studien har utförts genom en kvalitativ metod med semistrukturerade intervjuer. Respondenterna har bestått av tre representanter från berörd sameby, en representant från Piteå kommun samt en representant från ansvarig entreprenör. Empirin analyseras med hjälp utav ett teoretiskt ramverk bestående av teori gällande intressekonflikter, samt tidigare studier gällande markanvändning, ursprungsbefolkningar och etablering av vindkraft. Studien visar att de huvudsakliga konsekvenserna kan delas in i tre kategorier, nämligen fysiska konsekvenser, orosmoment samt avtal och stöd. De huvudsakliga konflikterna som kan identifieras innefattar utvecklings-, egendoms- och resurskonflikter. Samernas delaktighet i projektet har främst innefattat kommunikation och samråd med exploatören. Exploatören den aktören som haft en nyckelroll i delaktigheten mellan projektet och samebyn. Den största brytpunkten gällande samernas inställning till projektet var då ett avtal slöts mellan exploatören och samebyn, vilket gjorde samerna mer positivt inställda till projektet.

Rektorers pedagogiska ledarskap har betydelse för hur arbetet på skolorna fortlöper med syfte att främja särskilt begåvade elever i matematik och att dessa elever ska få den stimulans de är berättigade. Studiens syfte är att undersöka hur rektorer påverkas av ramfaktorer vid resursfördelning i matematik med fokus på särskilt begåvade elever. I studien har intervjuer använts som metod för att ta reda på rektorers påverkan av ramfaktorer vid resursfördelning i matematik. Ramfaktorteorin är den teori som beskriver vilka ramar och faktorer rektorer har att förhålla sig till. Resultatet visar att av rektorerna indirekt drar paralleller till budget i frågan om resursfördelningen, men kopplar också detta till flera andra ramfaktorer som samverkar. Alla rektorer uppger också att lärarnas egen kompetens är viktig för att kunna stimulera särskilt begåvade elever inom matematik. Slutsatsen i undersökningen blir därför att rektorers resursfördelning inom matematik med fokus på elever med särskild begåvning är styrd av flera faktorer och att dessa påverkar. De resultat som finns i studien kan ge ökad kunskap hos lärare eller andra kollegor för att det bidrar till en ökad medvetenhet om rektorers ramar och faktorer i det vardagliga arbetet. How school works with gifted students depends on the pedagogical leadership of the principals’ and their decisions regarding the distribution of resources. It’s these decisions that define how the students develop and if they get the right kind of stimulants that they need. The aim of this study is to examine how the frame factor theory influences the principals’ work with distributing resources for gifted students in mathematics. This study have been using interviews as method to find out how the frame factor theory influences principals work. The result of the study shows that principals instantly draw parallels to the budget in the question of distribution of resources, but also link this to several other framework factors that interact with each other. All of the principals state that the teachers’ competence is important in order to stimulate gifted students in mathematics. The conclusion of this study is that the principals are controlled by several of the factors in the frame factor theory regarding the distributing resources for gifted students in mathematics. The results from the study can increase the teachers’ knowledge, and other colleagues, and hopefully it can increase an awareness of how the principals' work regarding distributing resources for gifted students in mathematics are affected by the frame factor theory in their line of work every day.

© Copyright owned by the author(s) under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0). The DAQ and Timing Hub is an ATCA hub board designed for the Phase-2 upgrade of the CMS experiment. In addition to providing high-speed Ethernet connectivity to all back-end boards, it forms the bridge between the sub-detector electronics and the central DAQ, timing, and trigger control systems. One important requirement is the distribution of several high-precision, phase-stable, and LHC-synchronous clock signals for use by the timing detectors. The current paper presents first measurements performed on the initial prototype, with a focus on clock quality. It is demonstrated that the current design provides adequate clock quality to satisfy the requirements of the Phase-2 CMS timing detectors.

This report was done on behalf of Uppsala municipality with the aim to investigate how much the CO2-equivalent emissions differ between different building systems during the construction phase, considering the different choice of material used in the frames. Several multi-family houses with different building systems were therefore studied and compared by using previous LCA from collected climate reports regarding each construction project. Different scenarios of the residential development in Uppsala until year 2050, including multi- and single-family houses, were further on brought forward. The impact that the choice of material had on the climate was then studied by comparing the scenarios with the climate goals set up by Uppsala municipality regarding the construction sector. This was discussed in order to investigate whether Uppsala municipality would reach the climate goals or not. The conclusion of the study is that the building systems with wooden frames in general release less CO2-equivalent emissions than the ones with concrete frames. One of the reasons for this is that the production of the materials has different amounts of waste and the fact that concrete consists of cement, which causes a lot of emissions during the production of the material. Another part of the report was to investigate if climate improved concrete could decrease the CO2-equivalent emissions from building systems with concrete frames. This was done by doing a case-study, where parts of the concrete frame for one of the building systems were replaced, which resulted in a small decrease of the emissions. It is however, in a larger perspective, important to reduce the emissions as much as possible and there is still room to continue the improvement of concrete.

The rapid progress in the field of stem cell research has laid strong foundations for their use in regenerative medicine applications of injured or diseased tissues. Growing evidences indicate that some observed therapeutic outcomes of stem cell-based therapy are due to paracrine effects rather than long-term engraftment and survival of transplanted cells. Given their ability to cross biological barriers and mediate intercellular information transfer of bioactive molecules, extracellular vesicles are being explored as potential cell-free therapeutic agents. In this review, we first discuss the state of the art of regenerative medicine and its current limitations and challenges, with particular attention on pluripotent stem cell-derived products to repair organs like the eye, heart, skeletal muscle and skin. We then focus on emerging beneficial roles of extracellular vesicles to alleviate these pathological conditions and address hurdles and operational issues of this acellular strategy. Finally, we discuss future directions and examine how careful integration of different approaches presented in this review could help to potentiate therapeutic results in preclinical models and their good manufacturing practice (GMP) implementation for future clinical trials.

We present a tangible memory notebook--reMi--that records the ambient sounds and translates them into a tangible and shareable memory using animated paper. The paper replays the recorded sounds and deforms its shape to generate synchronized motions with the sounds. Computer-mediated communication interfaces have allowed us to share, record and recall memories easily through visual records. However, those digital visual-cues that are trapped behind the device's 2D screen are not the only means to recall a memory we experienced with more than the sense of vision. To develop a new way to store, recall and share a memory, we investigate how tangible motion of a paper that represents sound can enhance the "reminiscence".

Uppsatsen utgår ifrån hur socialarbetares vittnesmål problematiserar det sociala arbetets struktur gällande ekonomisk utsatthet bland barnfamiljer. Genom kvalitativa intervjuer undersöker studien hur barnfamiljer med svag ekonomi upplever att vardagen påverkas av deras ekonomiska situation, vad de tvingas avstå ifrån samt vilket stöd de erfarit från myndigheter och civilsamhälle. Studiens teoretiska ansats utgörs av Baumans teori om konsumtionssamhället, Goffmans Stigma, Bourdieus kapital samt Beckers stämplingsteori. Uppsatsens resultat påvisar hur familjernas upplevelser av ekonomisk utsatthet i Sverige 2018 skiljer sig ifrån varandra samtidigt som beröringspunkter kan uttydas; föräldrarnas krympta valmöjligheter att samt deras kamp för att ge sina barn möjligheter att delta i samhället på samma villkor som andra. Familjernas upplevelser av att tvingas avstå från saker som andra har av ekonomiska skäl förklarar den ekonomiska utsatthetens skiftningar och hur deprivationens omfattning varierar mellan studiens deltagare. Familjernas erfarenheter av stöd genom statliga myndigheter i samband med ekonomiska problem kan sammanfattas genom deras negativa erfarenheter av socialtjänstens bemötande. De flesta föredrar att vända sig till civilsamhällets ideella organisationer när de behöver stöd: ekonomiskt såväl som känslomässigt. Innebörden av familjernas upplevelser av att avvika från normen i konsumtionssamhället kan ifrågasätta tanken bakom en skälig levnadsnivå och statliga myndigheters förhållningssätt gentemot ekonomiskt utsatta barnfamiljer.