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3 results on '"Darin Wallentine"'

1. Assessment of the toxicity of firefighter exposures using the PAH CALUX bioassay

Author

Shawn C. Beitel, Leanne M. Flahr, Christiane Hoppe-Jones, Jefferey L. Burgess, Sally R. Littau, John Gulotta, Paul Moore, Darin Wallentine, and Shane A. Snyder

Subjects
Environmental sciences, GE1-350
Abstract

Firefighters can be exposed to a complex set of contaminants while at a fire scene. Identifying new ways to monitor and assess exposure, particularly relating to toxicity is essential to determine the effectiveness of intervention techniques to reduce exposure. This study investigated the use of the polycyclic aromatic hydrocarbon (PAH) CALUX® bioassay for the assessment of exposure and associated toxicity firefighters might encounter. This was done through analysis of extracts of dermal wipes and urine samples collected from firefighters before and after a controlled fire. An increased bioassay response was observed from post-fire neck and calf samples, indicating a greater concentration of PAH-like compounds on the skin. The use of a baby wipe to clean the face and neck during rehab resulted in the attenuation of the observed bioassay response from the neck post-fire. Though a correlation was observed between the bioassay response and hydroxylated PAH concentrations found in the urine, the increased bioassay response from the post-fire urine samples was likely due to unknown compounds other than the hydroxylated PAHs tested. Our results suggest that this bioassay provides a useful measure of firefighter exposure, particularly relating to the potential toxicity of contaminants. Keywords: Bioassay, PAH, Firefighters, Aryl hydrocarbon receptor

Published
2020
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2. Occupational Years of Service and Leukocyte Epigenetic Aging: Relationships in United States Firefighters

Author

Jamaji C. Nwanaji-Enwerem, Andres Cardenas, Jaclyn M. Goodrich, Melissa A. Furlong, Alesia M. Jung, Philip A. Collender, Alberto J. Caban-Martinez, Casey Grant, Shawn C. Beitel, Sally Littau, Derek J. Urwin, Jamie J. Gabriel, Jeff Hughes, John Gulotta, Darin Wallentine, and Jefferey L. Burgess

Subjects
Aging, epigenetic age, DNA methylation, EMS, Public Health, Environmental and Occupational Health, EMT, Nursing, United States, Environmental & Occupational Health, Good Health and Well Being, Genetic, healthy worker effect, Firefighters, Leukocytes, Genetics, Public Health and Health Services, Humans, Longitudinal Studies, Epigenesis
Abstract

ObjectiveThe aim of the study is to examine associations between years of firefighting service and eight chronological age-adjusted measures of blood leukocyte epigenetic age acceleration: Horvath, Hannum, SkinBloodClock, Intrinsic, Extrinsic, PhenoAge, GrimAge, and DNAm telomere length.MethodsThe study used a repeated measures analysis of data from 379 incumbent firefighters from eight career departments and 100 recruit firefighters from two of the departments, across the United States.ResultsIncumbent firefighters had on average greater epigenetic age acceleration compared with recruit firefighters, potentially due to the cumulative effect of occupational exposures. However, among incumbent firefighters, additional years of service were associated with epigenetic age deceleration, particularly for GrimAge, a strong predictor of mortality.ConclusionsLong-term studies with more specific occupational exposure classification are needed to better understand the relationship between years of service and aging biomarkers.

Published
2023

3. Repeat measures of DNA methylation in an inception cohort of firefighters

Author

Jaclyn M Goodrich, Alesia M Jung, Melissa A Furlong, Shawn Beitel, Sally Littau, John Gulotta, Darin Wallentine, and Jefferey L Burgess

Subjects
Firefighters, Neoplasms, Occupational Exposure, Public Health, Environmental and Occupational Health, Humans, DNA Methylation, Epigenesis, Genetic
Abstract

ObjectivesFirefighters face exposures associated with adverse health outcomes including risk for multiple cancers. DNA methylation, one type of epigenetic regulation, provides a potential mechanism linking occupational hazards to adverse health outcomes. We hypothesised that DNA methylation profiles would change in firefighters after starting their service and that these patterns would be associated with occupational exposures (cumulative fire-hours and fire-runs).MethodsWe profiled DNA methylation with the Infinium MethylationEPIC in blood leucocytes at two time points in non-smoking new recruits: prior to live fire training and 20–37 months later. Linear mixed effects models adjusted for potential confounders were used to identify differentially methylated CpG sites over time using data from 50 individuals passing all quality control.ResultsWe report 680 CpG sites with altered methylation (q value ConclusionsOverall, this study provides evidence that DNA methylation may be altered by fireground exposures, and the impact of this change on disease development should be evaluated.

Published
2021

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